SIRT7 (sirtuin 7) - Rat Genome Database

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Gene: SIRT7 (sirtuin 7) Pan paniscus
Analyze
Symbol: SIRT7
Name: sirtuin 7
RGD ID: 11917319
Description: ENCODES a protein that exhibits chromatin binding (inferred); histone H3K18 deacetylase activity, NAD-dependent (inferred); metal ion binding (inferred); INVOLVED IN protein deacetylation (ortholog); protein deglutarylation (ortholog); protein depropionylation (ortholog); PARTICIPATES IN histone modification pathway; RNA polymerase I transcription pathway; Sirtuin mediated pathway; ASSOCIATED WITH Reperfusion Injury (ortholog); steatotic liver disease (ortholog); systemic scleroderma (ortholog); FOUND IN nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: NAD-dependent protein deacetylase sirtuin-7
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21998,448,076 - 98,454,320 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117103,348,854 - 103,355,095 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01776,317,560 - 76,323,761 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11782,020,077 - 82,026,016 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1782,020,077 - 82,026,289 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SIRT7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21998,448,076 - 98,454,320 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117103,348,854 - 103,355,095 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01776,317,560 - 76,323,761 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11782,020,077 - 82,026,016 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1782,020,077 - 82,026,289 (-)Ensemblpanpan1.1panPan2
SIRT7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381781,911,939 - 81,918,176 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1781,911,939 - 81,921,323 (-)EnsemblGRCh38hg38GRCh38
GRCh371779,869,815 - 79,876,052 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361777,463,107 - 77,469,332 (-)NCBINCBI36Build 36hg18NCBI36
Celera1776,473,883 - 76,480,126 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1775,271,436 - 75,277,679 (-)NCBIHuRef
CHM1_11779,956,019 - 79,962,262 (-)NCBICHM1_1
T2T-CHM13v2.01782,779,099 - 82,785,336 (-)NCBIT2T-CHM13v2.0
Sirt7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911120,509,197 - 120,515,840 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11120,509,198 - 120,516,066 (-)EnsemblGRCm39 Ensembl
GRCm3811120,618,371 - 120,625,014 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,618,372 - 120,625,240 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711120,479,686 - 120,486,316 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611120,434,461 - 120,441,057 (-)NCBIMGSCv36mm8
Celera11132,353,665 - 132,360,296 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1184.34NCBI
Sirt7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,394,802 - 106,401,627 (-)NCBIGRCr8
mRatBN7.210105,896,476 - 105,903,301 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10105,896,476 - 105,903,172 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10111,000,317 - 111,006,939 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,463,345 - 110,469,976 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,816,930 - 105,823,624 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,796,046 - 109,802,821 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,796,020 - 109,802,739 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010109,389,098 - 109,395,852 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410110,009,669 - 110,016,346 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110110,024,660 - 110,030,830 (-)NCBI
Celera10104,439,874 - 104,446,570 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
Sirt7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555061,252,274 - 1,258,728 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555061,252,271 - 1,258,728 (+)NCBIChiLan1.0ChiLan1.0
SIRT7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.19377,141 - 383,355 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl9376,445 - 442,919 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha9979,255 - 985,455 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.09970,474 - 976,673 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl9969,764 - 976,672 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.19995,625 - 1,001,822 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.091,122,234 - 1,128,418 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.091,200,924 - 1,207,098 (+)NCBIUU_Cfam_GSD_1.0
Sirt7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602987,406 - 993,628 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365945,418,796 - 5,424,988 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365945,418,331 - 5,425,050 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIRT7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl121,078,166 - 1,084,119 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1121,078,155 - 1,084,112 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SIRT7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11673,785,223 - 73,792,773 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1673,785,695 - 73,791,947 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607745,237,380 - 45,244,127 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sirt7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480110,753,333 - 10,764,122 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480110,753,480 - 10,760,601 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000047686   ⟹   ENSPPAP00000024860
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1782,020,077 - 82,026,289 (-)Ensembl
RefSeq Acc Id: XM_034943138   ⟹   XP_034799029
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21998,448,076 - 98,454,320 (-)NCBI
NHGRI_mPanPan117103,348,854 - 103,355,095 (-)NCBI
Mhudiblu_PPA_v01776,317,560 - 76,323,761 (-)NCBI
RefSeq Acc Id: XR_010110738
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21998,448,567 - 98,454,320 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034799029 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000024860.1
RefSeq Acc Id: XP_034799029   ⟸   XM_034943138
- UniProtKB: A0A2R9B999 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000024860   ⟸   ENSPPAT00000047686
Protein Domains
Deacetylase sirtuin-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000035571 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000047686.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.28.200 UniProtKB/TrEMBL
  TPP-binding domain UniProtKB/TrEMBL
InterPro DHS-like_NAD/FAD-binding_dom UniProtKB/TrEMBL
  NAD-dep_sirtuin_deacylases UniProtKB/TrEMBL
  Sirtuin UniProtKB/TrEMBL
  Ssirtuin_cat_dom UniProtKB/TrEMBL
NCBI Gene SIRT7 ENTREZGENE
PANTHER NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-7 UniProtKB/TrEMBL
  NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED UniProtKB/TrEMBL
Pfam SIR2 UniProtKB/TrEMBL
PROSITE SIRTUIN UniProtKB/TrEMBL
Superfamily-SCOP SSF52467 UniProtKB/TrEMBL
UniProt A0A2R9B999 ENTREZGENE, UniProtKB/TrEMBL