ADRA1B (adrenoceptor alpha 1B) - Rat Genome Database

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Gene: ADRA1B (adrenoceptor alpha 1B) Pan paniscus
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Symbol: ADRA1B
Name: adrenoceptor alpha 1B
RGD ID: 11913279
Description: ENCODES a protein that exhibits alpha1-adrenergic receptor activity (ortholog); INVOLVED IN adult heart development (ortholog); behavioral response to cocaine (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; ASSOCIATED WITH Cardiomegaly (ortholog); Experimental Liver Cirrhosis (ortholog); hyperinsulinism (ortholog); FOUND IN intercalated disc (ortholog); T-tubule (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alpha-1B adrenergic receptor; LOC100970442
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24155,101,569 - 155,158,235 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15153,241,121 - 153,297,783 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05155,307,148 - 155,363,785 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15161,923,708 - 161,954,901 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5161,923,895 - 161,979,461 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating adrenergic receptor signaling pathway  (IEA)
adult heart development  (ISO)
behavioral response to cocaine  (ISO)
blood vessel remodeling  (ISO)
cell growth involved in cardiac muscle cell development  (ISO)
cell-cell signaling  (IEA)
G protein-coupled receptor signaling pathway  (IEA)
glucose homeostasis  (ISO)
glycogen catabolic process  (ISO)
locomotory behavior  (ISO)
negative regulation of glycogen catabolic process  (ISO)
negative regulation of Rho protein signal transduction  (ISO)
neuron-glial cell signaling  (ISO)
organ growth  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IEA)
positive regulation of cytosolic calcium ion concentration  (IEA,ISO)
positive regulation of glycogen catabolic process  (ISO)
positive regulation of heart rate by epinephrine-norepinephrine  (ISO)
positive regulation of MAPK cascade  (IEA)
positive regulation of the force of heart contraction by epinephrine-norepinephrine  (ISO)
regulation of blood pressure  (ISO)
regulation of cardiac muscle contraction  (IEA)
regulation of muscle contraction  (IEA)
regulation of vasoconstriction  (IEA)
response to amphetamine  (ISO)
response to estrogen  (ISO)
response to hormone  (ISO)
response to morphine  (ISO)
response to steroid hormone  (ISO)
response to xenobiotic stimulus  (ISO)
signal transduction  (IEA)
vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure  (ISO)
visual learning  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ADRA1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24155,101,569 - 155,158,235 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15153,241,121 - 153,297,783 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05155,307,148 - 155,363,785 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15161,923,708 - 161,954,901 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5161,923,895 - 161,979,461 (+)Ensemblpanpan1.1panPan2
ADRA1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385159,865,086 - 159,989,205 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5159,865,080 - 159,973,012 (+)EnsemblGRCh38hg38GRCh38
GRCh375159,343,489 - 159,400,019 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365159,276,318 - 159,332,595 (+)NCBINCBI36Build 36hg18NCBI36
Build 345159,276,317 - 159,332,129NCBI
Celera5155,374,535 - 155,430,824 (+)NCBICelera
Cytogenetic Map5q33.3NCBI
HuRef5154,438,201 - 154,494,477 (+)NCBIHuRef
CHM1_15158,776,756 - 158,833,023 (+)NCBICHM1_1
T2T-CHM13v2.05160,393,464 - 160,517,778 (+)NCBIT2T-CHM13v2.0
Adra1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391143,665,432 - 43,792,076 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1143,665,433 - 43,792,037 (-)EnsemblGRCm39 Ensembl
GRCm381143,774,605 - 43,901,250 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1143,774,606 - 43,901,210 (-)EnsemblGRCm38mm10GRCm38
MGSCv371143,588,108 - 43,649,834 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361143,618,029 - 43,679,755 (-)NCBIMGSCv36mm8
Celera1148,401,465 - 48,463,919 (-)NCBICelera
Cytogenetic Map11B1.1NCBI
cM Map1125.81NCBI
Adra1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81028,756,461 - 28,874,831 (-)NCBIGRCr8
mRatBN7.21028,255,025 - 28,373,418 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1028,255,025 - 28,312,919 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1033,014,641 - 33,072,459 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0101,553,026 - 1,610,850 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01027,985,197 - 28,043,019 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01029,392,762 - 29,450,644 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1029,392,762 - 29,450,644 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01029,233,972 - 29,291,344 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41028,889,092 - 28,946,889 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11028,890,140 - 28,947,938 (-)NCBI
Celera1027,744,674 - 27,802,198 (-)NCBICelera
Cytogenetic Map10q21NCBI
Adra1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540813,883,574 - 13,937,709 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540813,883,574 - 13,937,798 (+)NCBIChiLan1.0ChiLan1.0
ADRA1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1450,676,816 - 50,724,999 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl450,677,255 - 50,724,999 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha450,570,905 - 50,619,105 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0451,111,625 - 51,159,868 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl451,111,625 - 51,159,868 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1450,919,759 - 50,967,913 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0451,043,059 - 51,091,264 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0451,563,698 - 51,612,138 (-)NCBIUU_Cfam_GSD_1.0
Adra1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213105,074,452 - 105,123,271 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365153,523,797 - 3,572,596 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365153,523,799 - 3,572,467 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADRA1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1663,550,130 - 63,603,034 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11663,550,123 - 64,010,838 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21669,039,634 - 69,092,211 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADRA1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12362,281,500 - 62,338,290 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603415,270,198 - 15,333,460 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adra1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473329,545,789 - 29,662,028 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473329,545,870 - 29,661,954 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_034960903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSPPAT00000060214   ⟹   ENSPPAP00000037314
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5161,923,895 - 161,979,461 (+)Ensembl
RefSeq Acc Id: XM_034960903   ⟹   XP_034816794
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24155,101,569 - 155,158,235 (+)NCBI
NHGRI_mPanPan15153,241,121 - 153,297,783 (+)NCBI
Mhudiblu_PPA_v05155,307,148 - 155,363,785 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034816794 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000037314.1
RefSeq Acc Id: XP_034816794   ⟸   XM_034960903
- UniProtKB: A0A2R9C696 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000037314   ⟸   ENSPPAT00000060214
Protein Domains
G-protein coupled receptors family 1 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000041419 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000060214.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro ADR_fam UniProtKB/TrEMBL
  ADRA1B_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
NCBI Gene ADRA1B ENTREZGENE
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  PTHR24248:SF17 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS ADRENERGICR UniProtKB/TrEMBL
  ADRENRGCA1BR UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A2R9C696 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-06-11 ADRA1B  adrenoceptor alpha 1B  LOC100970442  alpha-1B adrenergic receptor  Data merged from RGD:12047947 737654 PROVISIONAL