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Gene: IREB2 (iron responsive element binding protein 2) Pan paniscus

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Symbol:

IREB2

Name:

iron responsive element binding protein 2

RGD ID:

11881557

Description:

ENCODES a protein that exhibits mRNA regulatory element binding translation repressor activity (ortholog); regulatory region RNA binding (ortholog); RNA binding (ortholog); INVOLVED IN cellular response to epidermal growth factor stimulus (ortholog); cellular response to hypoxia (ortholog); cellular response to iron(III) ion (ortholog); PARTICIPATES IN doxorubicin response pathway; iron homeostasis pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); anemia (ortholog); Bloom syndrome (ortholog); FOUND IN axon (ortholog); neuronal cell body (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

iron-responsive element-binding protein 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	67,651,465 - 67,714,569 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	71,817,336 - 71,880,436 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	57,367,314 - 57,430,322 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	76,331,610 - 76,394,476 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	76,331,610 - 76,394,476 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

anemia (ISO)

Bloom syndrome (ISO)

Brain Hypoxia (ISO)

Brain Hypoxia-Ischemia (ISO)

colorectal cancer (ISO)

genetic disease (ISO)

hyperinsulinism (ISO)

iron deficiency anemia (ISO)

Iron Overload (ISO)

lung adenocarcinoma (ISO)

Neoplasm Invasiveness (ISO)

neuroaxonal dystrophy (ISO)

NEURODEGENERATION, EARLY-ONSET, WITH CHOREOATHETOID MOVEMENTS AND MICROCYTIC ANEMIA (ISO)

neurodegenerative disease (ISO)

Postoperative Cognitive Dysfunction (ISO)

Vitamin A Deficiency (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to epidermal growth factor stimulus (ISO)

cellular response to hypoxia (ISO)

cellular response to iron(III) ion (ISO)

cellular response to manganese ion (ISO)

cellular response to mercaptoethanol (ISO)

cellular response to retinoic acid (ISO)

erythrocyte homeostasis (IEA,ISO)

intestinal absorption (IEA,ISO)

intracellular iron ion homeostasis (IEA,ISO)

multicellular organismal-level iron ion homeostasis (IEA,ISO)

negative regulation of translation (ISO)

osteoclast differentiation (IEA)

post-embryonic development (IEA,ISO)

protoporphyrinogen IX biosynthetic process (IEA,ISO)

regulation of gene expression (IEA,ISO)

regulation of translation (IEA,ISO)

response to activity (ISO)

response to copper ion (ISO)

response to hypobaric hypoxia (ISO)

response to iron(II) ion (ISO)

response to iron(III) ion (ISO)

response to kainic acid (ISO)

response to retinoic acid (ISO)

response to zinc ion (ISO)

skeletal muscle atrophy (ISO)

Cellular Component

axon (ISO)

cytoplasm (IEA)

cytosol (IEA)

neuronal cell body (ISO)

Molecular Function

4 iron, 4 sulfur cluster binding (IEA)

iron-responsive element binding (IEA)

metal ion binding (IEA)

mRNA regulatory element binding translation repressor activity (ISO)

protein binding (ISO)

regulatory region RNA binding (ISO)

RNA binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

doxorubicin response pathway (ISO)

iron homeostasis pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

IREB2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	67,651,465 - 67,714,569 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	71,817,336 - 71,880,436 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	57,367,314 - 57,430,322 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	76,331,610 - 76,394,476 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	76,331,610 - 76,394,476 (+)	Ensembl	panpan1.1		panPan2

IREB2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	78,437,431 - 78,501,453 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	78,437,431 - 78,501,453 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	78,729,773 - 78,793,795 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	76,517,573 - 76,580,853 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	76,517,680 - 76,578,522	NCBI
Celera	15	55,667,049 - 55,730,320 (+)	NCBI		Celera
Cytogenetic Map	15	q25.1	NCBI
HuRef	15	55,487,914 - 55,551,183 (+)	NCBI		HuRef
CHM1_1	15	78,849,070 - 78,912,332 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	76,300,098 - 76,364,103 (+)	NCBI		T2T-CHM13v2.0

Ireb2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	54,769,942 - 54,819,812 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	54,771,073 - 54,819,814 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	54,862,658 - 54,912,534 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	54,863,789 - 54,912,530 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	54,711,562 - 54,760,341 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	54,661,926 - 54,708,169 (+)	NCBI		MGSCv36	mm8
Celera	9	52,108,353 - 52,158,699 (+)	NCBI		Celera
Cytogenetic Map	9	B	NCBI
cM Map	9	29.81	NCBI

Ireb2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	64,124,152 - 64,207,702 (+)	NCBI		GRCr8
mRatBN7.2	8	55,228,080 - 55,311,613 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	55,228,085 - 55,311,611 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	60,806,571 - 60,850,679 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	59,085,567 - 59,129,675 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	56,949,805 - 56,993,913 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	59,450,974 - 59,503,634 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	59,420,123 - 59,501,118 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	58,002,720 - 58,085,793 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	58,433,218 - 58,477,305 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	58,452,371 - 58,496,928 (+)	NCBI
Celera	8	54,752,036 - 54,796,112 (+)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

Ireb2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955450	852,554 - 900,011 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955450	852,554 - 898,908 (+)	NCBI	ChiLan1.0	ChiLan1.0

IREB2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	38,398,445 - 38,441,128 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	38,400,591 - 38,441,015 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	38,376,325 - 38,418,383 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	38,889,612 - 38,931,847 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	38,889,614 - 38,931,872 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	38,580,619 - 38,622,667 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	38,690,365 - 38,732,612 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	39,165,328 - 39,207,352 (-)	NCBI		UU_Cfam_GSD_1.0

Ireb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	118,699,487 - 118,752,521 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	36,547,500 - 36,600,636 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	36,547,552 - 36,601,327 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IREB2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	47,478,706 - 47,529,242 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	47,481,539 - 47,529,199 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	52,974,224 - 53,021,936 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

IREB2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	4,842,328 - 4,905,941 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	4,842,122 - 4,905,964 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	136,891,175 - 136,954,571 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ireb2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624894	2,445,704 - 2,499,009 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624894	2,446,014 - 2,498,650 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003813812	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008966419	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008966420	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_057299917	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063596866	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000054998 ⟹ ENSPPAP00000032132

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	15	76,331,610 - 76,394,476 (+)	Ensembl

RefSeq Acc Id:

XM_003813812 ⟹ XP_003813860

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	16	67,651,465 - 67,714,569 (+)	NCBI
NHGRI_mPanPan1	15	71,817,336 - 71,880,436 (+)	NCBI
Mhudiblu_PPA_v0	15	57,367,314 - 57,430,322 (+)	NCBI
PanPan1.1	15	76,331,610 - 76,394,476 (+)	NCBI

Sequence:

show sequence

GGGCTGGCTCTGCGGCTCTCGCGATATTTGCGCGAGCCTGCTTCCTTCTTTCCTCCCTTGCCAG
TCCGCCTGTCTTCCTCCCCGTCTTCCCTGCCCGGCCTCCCCCTTCTTCCCCCGCTGGCCCCCTC
CCCGGAGGGATAATATGGTCTCCGGCGATGGACGCCCCAAAAGCAGGATACGCCTTTGAGTACC
TTATTGAAACATTAAATGACAGTTCACGTAAGAAGTTCTTCGATGTATCTAAACTTGGCACCAA
GTATGATGTTCTGCCTTACTCAATACGGGTCTTGTTGGAAGCTGCTGTACGAAATTGTGATGGC
TTTTTAATGACGAAGGAAGATGTTATGAACATTTTAGACTGGAAAACCAAACAAAGCAATGTTG
AAGTGCCCTTTTTCCCTGCCCGTGTTCTTCTTCAAGATTTTACTGGAATACCAGCAATGGTGGA
TTTTGCTGCTATGAGGGAGGCAGTGAAAACTCTTGGAGGTGATCCTGAGAAAGTCCATCCTGCT
TGTCCGACAGATCTTACAGTTGACCATTCTTTACAAATTGACTTCAGTAAATGTGCAATACAGA
ATGCACCAAATCCTGGAGGTGGTGACCTGCAGAAAGCAGGAAAGCTCTCTCCACTTAAAGTGCA
GCCTAAGAAGCTTCCCTGCAGAGGCCAGACTACCTGCCGAGGATCTTGTGATTCTGGAGAACTA
GGCCGAAACTCAGGAACATTTTCTTCGCAGATTGAGAATACACCCATCCTGTGTCCTTTTCATT
TGCAACCAGTGCCTGAACCTGAAACAGTGTTAAAAAATCAAGAAGTAGAATTCGGCAGAAATCG
AGAGAGGCTTCAGTTTTTTAAGTGGAGTTCAAGAGTTTTTAAGAATGTGGCAGTGATCCCTCCT
GGAACTGGAATGGCTCATCAAATAAACTTAGAATATTTGTCAAGAGTGGTTTTTGAAGAAAAAG
TCCTCCTCTTCCCAGACAGTGTGGTCGGCACAGATTCACACATAACGATGGTGAATGGTTTAGG
GATTCTGGGGTGGGGGGTTGGAGGCATTGAAACAGAAGCAGTTATGCTTGGTCTGCCAGTTTCT
CTTACTTTACCAGAGGTGGTTGGATGTGAGTTAACTGGGTCATCAAACCCTTTTGTTACATCCA
TAGATGTTGTTCTTGGTATTACAAAGCACCTCAGGCAAGTAGGAGTGGCTGGAAAGTTTGTTGA
GTTTTTTGGAAGTGGAGTTTCACAATTATCTATAGTTGATCGAACTACAATAGCAAACATGTGT
CCGGAATATGGTGCTATCCTCAGCTTTTTCCCTGTTGACAATGTGACATTAAAACATTTAGAAC
ATACAGGTTTTAGCAAAGCCAAACTCGAATCAATGGAAACATACCTTAAAGCTGTGAAATTGTT
TCGAAATGACCAGAATTCTTCAGGAGAACCTGAATACTCCCAGGTGATCCAGATTAATCTGAAT
TCAATAGTTCCATCTGTTAGTGGTCCAAAAAGACCTCAGGATAGAGTTGCTGTGACAGATATGA
AAAGCGATTTCCAGGCTTGCTTAAATGAAAAGGTTGGATTTAAAGGCTTCCAAATTGCAGCTGA
AAAACAAAAGGATATTGTCTCCATTCATTATGAAGGAAGTGAATATAAGCTGTCTCATGGATCA
GTGGTCATTGCTGCAGTTATCAGTTGTACCAATAATTGCAATCCATCTGTCATGCTTGCTGCAG
GTCTTTTGGCTAAAAAGGCTGTTGAAGCTGGTCTGCGTGTTAAACCTTATATAAGAACAAGTTT
ATCTCCAGGCAGTGGGATGGTTACACATTACCTCAGTTCAAGTGGAGTATTACCATATCTCAGT
AAGCTTGGATTTGAAATCGTTGGCTATGGATGTTCAACTTGTGTGGGAAATACAGCACCCTTAT
CAGACGCAGTTTTAAATGCAGTAAAACAGGGTGATTTGGTTACCTGTGGAATTTTATCTGGAAA
CAAAAATTTTGAAGGTCGTCTTTGTGATTGTGTTCGTGCCAATTATCTTGCCTCTCCACCCTTA
GTGGTAGCTTATGCCATAGCAGGCACAGTGAATATAGATTTCCAGACAGAACCTTTAGGTACTG
ACCCCACCGGCAAGAACATTTACCTGCATGATATTTGGCCTAGTCGAGAAGAAGTTCATCGAGT
AGAGGAAGAACATGTTATACTATCCATGTTTAAAGCATTAAAAGATAAAATAGAAATGGGGAAT
AAACGGTGGAATTCCTTAGAAGCACCGGATTCAGTTTTGTTTCCATGGGACTTAAAGTCTACTT
ATATCAGATGCCCTTCATTTTTTGATAAACTTACCAAAGAGCCAATTGCACTCCAGGCTATTGA
AAATGCCCATGTCTTATTATATTTGGGAGACTCTGTCACAACAGATCATATATCACCTGCAGGA
AGTATCGCTAGGAATAGTGCTGCCGCTAAGTATTTGACAAACAGAGGCCTTACCCCTCGTGAAT
TCAACTCTTACGGAGCTCGAAGAGGTAATGATGCTGTAATGACAAGAGGCACTTTTGCAAATAT
CAAGCTTTTTAATAAGTTTATTGGAAAACCAGCTCCTAAAACAATTCATTTTCCATCAGGACAG
ACGCTAGATGTATTTGAGGCTGCAGAGCTGTACCAGAAAGAAGGTATCCCACTGATTATTTTAG
CAGGAAAGAAATATGGTTCAGGAAACTCCAGAGACTGGGCTGCCAAAGGACCGTATTTACTGGG
TGTGAAAGCTGTTTTGGCCGAAAGTTATGAAAAAATACACAAAGATCATTTGATTGGAATTGGC
ATAGCTCCACTTCAGTTCCTTCCAGGAGAAAATGCAGATTCCTTGGGCCTCTCCGGTAGAGAAA
CATTTTCTTTAACATTTCCTGAAGAACTGTCTCCTGGAATTACATTGAATATACAGACAAGCAC
TGGAAAAGTATTCAGCGTGATTGCTTCGTTTGAAGATGATGTGGAAATAACATTATACAAACAT
GGAGGATTATTAAACTTTGTGGCACGAAAATTCTCATAGTATCTACTTACCATAGATACCTTTC
ATAACTGGTAACTGCAAAGCCTTTTGTGCTGGACCCAGGAATCCTTACCATGGAGCAGCAGATA
GTCCCAGTATACTCACTTATCTCATCCATGGATGTAAATGATGATGAATCAACATAGTAACTGA
AATGAAATCTTCTTGATTTTAAATAATATACGAATGGTGCTATTAATACTGCTAAAATCAACAT
GTGAAGTGTGTTGTGGAAGAGATCTGTAAGTATGGGGGGGGCGATATTTTATCAGACCATTTTG
TAAATAAAGGCAGAATTTGTGTTGAAGATTCTTATATGAATAACCTTCCTGGATTTGTTTAGTT
TTGCACCAATAAAACTGTGTACTACTGTTTGTTGGTTTAAGAGTAGCAGATTGAAATATAAGAA
GCCAGATTAGACTCTAAAATTGTGGCCATTGGAATCTCATTTATAAATGGACCTTTTAAGTATA
TTAATTCCTCTTCAGAATTGAGCTGGACACATTTGGCATTCTTAGTTTGTCATATAACCAAGTT
TATCCTTAGTCTAACTGCAAGGGATAGAACCTGCCCTGGGTCACAATCATTCTGTCCAATCCAG
CCAAGGTTCCCTCCACATATGAAGATGGACCATGGCAGGATACAACTGATTGTGTGGCACCATG
TATTAGCAGTGGGAATATGTATCACATATGATGCAGCCTTTCATGTTTCAGCAGTTTGCCACTG
TGACTGTCTGGCAAGCCCCCAGATGGCATTATATTAATTGGATTAGATTATTTTGCTCACCTTA
TGTAATACCGTAACTTCCTATAACCTAATATTTTCGGTATCATTAACCAAAATTTCACACTCAT
AGTTGCTAAAGAGAATGTTATTCAATCATTAAACTCTGAACTGATTTCTTCTATACATTTAAAT
TATCCACCCTCAATAATACGGGTGCTCAACCCTATGCATTTTTTAAGTGTTGCTATTTCTTAAT
TAAATTGATTTCCTGTCATTTTGAATCATTTATCACCTGCAATGCATGATTCTATTAATTTTGT
TATGTTACTGTTTTAACCAAAGCTGACCATAAGGATAAAACACTTAAGTTGTTGCTGAGTACTA
TATATCCTCAATATGCATGTCTGCCCATCACATCAAATGTTCTGTCAACAAGATGTTTGGTAAT
TTTTTAAAAAGGTTGGAAAATTAATTATAGAAGGTTCTATACCGTTTTTTTAATTAAGAAACTA
AATCTAGCAGGCTAAAGGTTAATTGTAGTGATTTTTTTTCACATAGCTATCTTTCTATGACCTA
GTTAGTTACTGCAATTCAGAATTAGTTCACATTGCATAAAGAATTACTTGTTTTAAGCAAAATG
CTGAAACTACCAAACCAGTGGATGAAGACCACTAAGAACTTTGCACATAATCATACAATCTTTT
GAAAATATTTTGCAAATATGTGTTTAGACAATAAGATGGACTAGAGTTCGACAAAATGATTTCT
TTATTTAAATTTTGTGTAAGTATTTTCTTCGACACTTTCAAATTATATTGTGTTCTTGATATAT
GCTGTATATTTATTTGTTAGTGCATGTGTTTTTAATTTACATGAAAACATGAGTTAGGAGAAAT
TACAGGTTGAAAGATGAAATGCCTGTATGTGCTCTGAAGAAATGGTAATTCCAGATTGTGCAGG
GGGAAACAAATCTATTTTGTTTTGTTTTGTTTTTTGAGACGGAGTCTTGCCCTGTGGCTGGGCT
GGAGTGCAATGGCGCAATCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGGGATTCTCCT
GCCTCAGCCTCCTGAGTAGCTGGGACTACAAGCATGCACCACCACGCCCAGCTAATTTCTGTAG
TTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGATGATCTGAATCTCTTGACCTCGTGATCC
GCCCGCCTTGGCCTCCACAAGTGCTGGGATTACAGGTGTGAGCCACCACACCCGGCCTATATTG
TTTTGAAAGCATACTCTATATATATTTATGGGCAGAGGCACAGGCATCCTCAGCAGCTGATTCA
GGAGATGATGGTAAAGCTTGCTAACTATGAATTAAACATTCACATATCCAGTCTACCTGGTCCA
GTAATAATACAAGCAAATCTTGTATTTCAGGAACAAATCAAGGTTCTCTTAATTTTTTGGCTTA
TATACAATGAAGTAAAAACTTGATAAACATGGTTTCAAATTGAGGAGGAGAGTCTTGGATGTAT
GTTTTAACATGTATACCTTATAATTCTGCCTCTAGCCAAATGCTATGTTTGCAAAATGTGGCAT
CTGTTAGTTTTTATTGTCTGTGTCTTCTTTGTTGACTATACCTTGGGTAATTTTGTGTTACCAA
AAAAAAAAAGGAAAGTGTAATGTCAGACACACAAGAAAAGCAAATCAGTGTTGTAAGCTTAAAG
TACAATTTCAAAGGTCATTACCAACAGCAGGGGTTTTTTAATACTTTAAAAACATTATGCTACA
TATCATTGCCATTTTCATATTTTGGGGTTTTGCTACTCTTATACAATGGAATCAATGGAAATGT
CATCCAGCCACTGAATTGCCATTATTATATCTAAAAAGTTTCTAAGATGACAGTTATCACTATT
TTGTTTTATCTCCATGCTGACATTTGAAAGAAGGTACTAGTATCCCTCTAGCCAGATTGCTTAG
TTTTTCATTGGTAATCAAACAACAGTTGTACTAAAGGAAAGTAAAGCTAGGACCTAAATCAGAA
TCATAGTTGCCTGCGTATATGGTAACAAGGTTGTGTGCATTTGCTTTCACAGTGATGAGTGAGA
GGATGAGAAGAAATTATTTGACATTTTTCTGTGGTTGAATGGAAGACACCTTTCTTTTGTCTTT
AGGTTTAGGAGGAGATACTAAGATACTGGATGTTTATCCTATCTTAGTTTGGTTGGAGTAATAA
GAGAGAAGAAGAGGATGGACTTTGGCTTTTTCAGTGTTTTTTCCCCTAAAGAGTGATATTGCTG
ATGTTTCTATCAATTTTACACATAATATGTGGCTATGAAACCATATATCTCACTTAAGTAACAA
AGTAATCACTTTGTCTATCACTAAGTAATAGACAAAAATCATTGTCTATTATTTAAAGCCAACA
AAACAGTGTAACAGTTTTAAGTTCAATAATATTAAGTATTGTATAGAAATATATTGGAGGCAAA
GTTCAGTTGATGACAATTGTGTATATGTTACTGATGCTGTAAATTATTTTTAATAAAGAAAATT
GTATTATCA

hide sequence

RefSeq Acc Id:

XM_057299917 ⟹ XP_057155900

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	16	67,652,200 - 67,714,569 (+)	NCBI
NHGRI_mPanPan1	15	71,818,071 - 71,880,436 (+)	NCBI

RefSeq Acc Id:

XM_063596866 ⟹ XP_063452936

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	16	67,674,333 - 67,714,569 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_003813860	(Get FASTA)	NCBI Sequence Viewer
	XP_057155900	(Get FASTA)	NCBI Sequence Viewer
	XP_063452936	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000032132.1

RefSeq Acc Id:	XP_003813860 ⟸ XM_003813812
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9BR28 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDAPKAGYAFEYLIETLNDSSRKKFFDVSKLGTKYDVLPYSIRVLLEAAVRNCDGFLMTKEDVM NILDWKTKQSNVEVPFFPARVLLQDFTGIPAMVDFAAMREAVKTLGGDPEKVHPACPTDLTVDH SLQIDFSKCAIQNAPNPGGGDLQKAGKLSPLKVQPKKLPCRGQTTCRGSCDSGELGRNSGTFSS QIENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSRVFKNVAVIPPGTGMAHQIN LEYLSRVVFEEKVLLFPDSVVGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVSLTLPEVVGC ELTGSSNPFVTSIDVVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSF FPVDNVTLKHLEHTGFSKAKLESMETYLKAVKLFRNDQNSSGEPEYSQVIQINLNSIVPSVSGP KRPQDRVAVTDMKSDFQACLNEKVGFKGFQIAAEKQKDIVSIHYEGSEYKLSHGSVVIAAVISC TNNCNPSVMLAAGLLAKKAVEAGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGY GCSTCVGNTAPLSDAVLNAVKQGDLVTCGILSGNKNFEGRLCDCVRANYLASPPLVVAYAIAGT VNIDFQTEPLGTDPTGKNIYLHDIWPSREEVHRVEEEHVILSMFKALKDKIEMGNKRWNSLEAP DSVLFPWDLKSTYIRCPSFFDKLTKEPIALQAIENAHVLLYLGDSVTTDHISPAGSIARNSAAA KYLTNRGLTPREFNSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAE LYQKEGIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLPG ENADSLGLSGRETFSLTFPEELSPGITLNIQTSTGKVFSVIASFEDDVEITLYKHGGLLNFVAR KFS hide sequence

Ensembl Acc Id:

ENSPPAP00000032132 ⟸ ENSPPAT00000054998

RefSeq Acc Id:	XP_057155900 ⟸ XM_057299917
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R9BR28 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063452936 ⟸ XM_063596866
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R9BR28 (UniProtKB/TrEMBL)

Protein Domains

Aconitase A/isopropylmalate dehydratase small Aconitase/3-isopropylmalate dehydratase large

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000038956	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000054998.1	UniProtKB/TrEMBL
Gene3D-CATH	3.20.19.10	UniProtKB/TrEMBL
	3.30.499.10	UniProtKB/TrEMBL
	6.10.190.10	UniProtKB/TrEMBL
InterPro	AcnA_IRP_Swivel	UniProtKB/TrEMBL
	Acnase/IPM_dHydase_lsu_aba_1/3	UniProtKB/TrEMBL
	Acoase/IPM_deHydtase_lsu_aba	UniProtKB/TrEMBL
	Aconitase/3IPM_dehydase_swvl	UniProtKB/TrEMBL
	Aconitase/IRP2	UniProtKB/TrEMBL
	Aconitase_4Fe-4S_BS	UniProtKB/TrEMBL
	Aconitase_4Fe-4S_dom	UniProtKB/TrEMBL
	AconitaseA/IPMdHydase_ssu_swvl	UniProtKB/TrEMBL
KEGG Report	pps:100989915	UniProtKB/TrEMBL
NCBI Gene	IREB2	ENTREZGENE
PANTHER	PTHR11670	UniProtKB/TrEMBL
	PTHR11670:SF31	UniProtKB/TrEMBL
Pfam	Aconitase	UniProtKB/TrEMBL
	Aconitase_C	UniProtKB/TrEMBL
PRINTS	ACONITASE	UniProtKB/TrEMBL
PROSITE	ACONITASE_1	UniProtKB/TrEMBL
	ACONITASE_2	UniProtKB/TrEMBL
Superfamily-SCOP	LeuD/IlvD-like	UniProtKB/TrEMBL
	SSF53732	UniProtKB/TrEMBL
UniProt	A0A2R9BR28	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

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