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Gene: LOC100977072 (neuronal acetylcholine receptor subunit alpha-7) Pan paniscus

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Symbol:

LOC100977072 (Ensembl: CHRNA7)

Name:

neuronal acetylcholine receptor subunit alpha-7 (Ensembl:cholinergic receptor nicotinic alpha 7 subunit)

RGD ID:

11879084

Description:

ENCODES a protein that exhibits acetylcholine binding (ortholog); acetylcholine receptor activity (ortholog); acetylcholine-gated monoatomic cation-selective channel activity (ortholog); INVOLVED IN acetylcholine receptor signaling pathway (ortholog); activation of protein kinase C activity (ortholog); associative learning (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; ASSOCIATED WITH Alzheimer's disease (ortholog); attention deficit hyperactivity disorder (ortholog); Auditory Perceptual Disorders (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); apical plasma membrane (ortholog); asymmetric synapse (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cholinergic receptor nicotinic alpha 7 subunit; CHRNA7

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	20,841,679 - 20,981,068 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	25,565,746 - 25,705,121 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	10,525,535 - 10,667,227 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	29,565,885 - 29,705,194 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	29,565,885 - 29,705,194 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

attention deficit hyperactivity disorder (ISO)

Auditory Perceptual Disorders (ISO)

autism spectrum disorder (ISO)

autistic disorder (ISO)

Binge Drinking (ISO)

Brain Injuries (ISO)

chromosome 15q11.2 deletion syndrome (ISO)

chromosome 15q13.3 microdeletion syndrome (ISO)

chronic obstructive pulmonary disease (ISO)

cognitive disorder (ISO)

colorectal cancer (ISO)

COVID-19 (ISO)

Crohn's disease (ISO)

esophagus squamous cell carcinoma (ISO)

Experimental Colitis (ISO)

generalized epilepsy (ISO)

Hyperalgesia (ISO)

Idiopathic Generalized Epilepsy 7 (ISO)

Lewy body dementia (ISO)

lung cancer (ISO)

Lung Neoplasms (ISO)

lung non-small cell carcinoma (ISO)

malignant pleural mesothelioma (ISO)

Memory Disorders (ISO)

Neoplasm Invasiveness (ISO)

Nerve Degeneration (ISO)

Neurobehavioral Manifestations (ISO)

Neurodevelopmental Disorders (ISO)

nicotine dependence (ISO)

rheumatoid arthritis (ISO)

schizophrenia (ISO)

Spina Bifida Cystica (ISO)

sudden infant death syndrome (ISO)

ulcerative colitis (ISO)

umbilical hernia (ISO)

withdrawal disorder (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acetylcholine receptor signaling pathway (ISO)

activation of protein kinase C activity (ISO)

associative learning (ISO)

B cell activation (ISO)

behavioral response to ethanol (ISO)

behavioral response to nicotine (ISO)

calcium ion transport (ISO)

chemical synaptic transmission (ISO)

cognition (ISO)

dendrite arborization (ISO)

dendritic spine organization (ISO)

dopamine biosynthetic process (ISO)

endocytosis (ISO)

establishment of localization in cell (ISO)

excitatory postsynaptic potential (IEA)

flagellated sperm motility (ISO)

generation of ovulation cycle rhythm (ISO)

intracellular calcium ion homeostasis (ISO)

learning or memory (ISO)

ligand-gated ion channel signaling pathway (ISO)

memory (ISO)

modulation of chemical synaptic transmission (ISO)

modulation of excitatory postsynaptic potential (ISO)

monoatomic ion transmembrane transport (IEA,ISO)

monoatomic ion transport (IEA,ISO)

negative regulation of amyloid-beta formation (ISO)

negative regulation of canonical NF-kappaB signal transduction (ISO)

negative regulation of cytokine production involved in inflammatory response (ISO)

negative regulation of ERK1 and ERK2 cascade (ISO)

negative regulation of inflammatory response (ISO)

negative regulation of interleukin-1 beta production (ISO)

negative regulation of interleukin-6 production (ISO)

negative regulation of tumor necrosis factor production (ISO)

neuronal action potential (ISO)

ovulation cycle (ISO)

positive regulation of amyloid-beta formation (ISO)

positive regulation of angiogenesis (ISO)

positive regulation of cell population proliferation (ISO)

positive regulation of ERK1 and ERK2 cascade (ISO)

positive regulation of excitatory postsynaptic potential (ISO)

positive regulation of gene expression (ISO)

positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure (ISO)

positive regulation of long-term synaptic potentiation (ISO)

positive regulation of MAPK cascade (ISO)

positive regulation of protein metabolic process (ISO)

presynaptic modulation of chemical synaptic transmission (ISO)

regulation of amyloid fibril formation (ISO)

regulation of amyloid precursor protein catabolic process (ISO)

regulation of inflammatory response (ISO)

regulation of membrane potential (ISO)

regulation of norepinephrine secretion (ISO)

regulation of postsynaptic membrane potential (IEA)

regulation of response to drug (ISO)

regulation of synapse structural plasticity (ISO)

regulation of synaptic transmission, dopaminergic (ISO)

response to acetylcholine (ISO)

response to amyloid-beta (ISO)

response to carbamate (ISO)

response to cold (ISO)

response to ethanol (ISO)

response to food (ISO)

response to hypoxia (ISO)

response to nicotine (ISO)

sensory processing (ISO)

signal transduction (ISO)

synapse organization (ISO)

synaptic transmission involved in micturition (ISO)

synaptic transmission, cholinergic (ISO)

T cell activation (ISO)

Cellular Component

acetylcholine-gated channel complex (ISO)

apical plasma membrane (ISO)

asymmetric synapse (ISO)

axolemma (ISO)

axon (ISO)

cation channel complex (ISO)

cholinergic synapse (ISO)

dendrite (ISO)

dendritic shaft (ISO)

dendritic spine (ISO)

external side of plasma membrane (ISO)

glycinergic synapse (ISO)

growth cone (ISO)

membrane (IEA)

neuronal cell body (ISO)

neurotransmitter receptor complex (ISO)

plasma membrane (IEA,ISO)

plasma membrane raft (ISO)

postsynaptic membrane (IEA,ISO)

postsynaptic specialization membrane (ISO)

presynaptic membrane (ISO)

spine apparatus membrane (ISO)

synapse (IEA)

Molecular Function

acetylcholine binding (ISO)

acetylcholine receptor activity (ISO)

acetylcholine-gated monoatomic cation-selective channel activity (IEA,ISO)

adenylate cyclase binding (ISO)

amyloid-beta binding (ISO)

ATPase binding (ISO)

chloride channel regulator activity (ISO)

extracellular ligand-gated monoatomic ion channel activity (IEA)

monoatomic ion channel activity (IEA)

protein binding (ISO)

protein homodimerization activity (ISO)

protein kinase binding (ISO)

scaffold protein binding (ISO)

toxic substance binding (ISO)

transmembrane signaling receptor activity (IEA)

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

acetylcholine signaling pathway via nicotinic acetylcholine receptor (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

LOC100977072
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	20,841,679 - 20,981,068 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	25,565,746 - 25,705,121 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	10,525,535 - 10,667,227 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	29,565,885 - 29,705,194 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	29,565,885 - 29,705,194 (+)	Ensembl	panpan1.1		panPan2

CHRNA7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	32,030,483 - 32,173,018 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	31,923,438 - 32,173,018 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	32,322,686 - 32,465,219 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	30,110,018 - 30,248,541 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	30,110,017 - 30,248,525	NCBI
Celera	15	8,162,865 - 8,292,202 (-)	NCBI		Celera
Cytogenetic Map	15	q13.3	NCBI
HuRef	15	9,499,328 - 9,603,273 (+)	NCBI		HuRef
CHM1_1	15	32,312,897 - 32,452,812 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	29,824,630 - 29,967,342 (+)	NCBI		T2T-CHM13v2.0

Chrna7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	62,748,440 - 62,862,274 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	62,748,440 - 62,862,317 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	63,098,692 - 63,212,526 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	63,098,692 - 63,212,569 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	70,243,578 - 70,357,412 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	62,977,642 - 63,091,468 (-)	NCBI		MGSCv36	mm8
Celera	7	60,542,827 - 60,660,378 (-)	NCBI		Celera
Cytogenetic Map	7	C	NCBI
cM Map	7	34.47	NCBI

Chrna7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	126,123,425 - 126,249,181 (-)	NCBI		GRCr8
mRatBN7.2	1	116,711,559 - 116,837,269 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	116,714,711 - 116,837,240 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	124,676,761 - 124,793,917 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	131,859,276 - 131,976,435 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	124,684,982 - 124,802,138 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	123,897,341 - 124,039,263 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	123,899,657 - 124,039,196 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	125,029,451 - 125,158,153 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	117,587,580 - 117,716,267 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	117,665,347 - 117,794,621 (-)	NCBI
Celera	1	108,976,664 - 109,097,764 (-)	NCBI		Celera
Cytogenetic Map	1	q22	NCBI

Chrna7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955416	30,687,478 - 30,798,700 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955416	30,687,518 - 30,798,700 (+)	NCBI	ChiLan1.0	ChiLan1.0

CHRNA7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	36,852,082 - 37,164,930 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	36,852,543 - 36,978,399 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	39,517,659 - 39,644,156 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	37,232,973 - 37,359,572 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	37,231,040 - 37,360,220 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	36,756,424 - 36,882,829 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	37,011,929 - 37,138,401 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	37,222,873 - 37,349,426 (-)	NCBI		UU_Cfam_GSD_1.0

Chrna7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	146,502,956 - 146,512,072 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004937351	34,921 - 47,246 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004937351	32,324 - 46,871 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CHRNA7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	142,803,701 - 142,937,123 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	142,803,697 - 142,937,124 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	158,717,002 - 158,849,994 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CHRNA7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	50,554,143 - 50,686,847 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	50,551,829 - 50,686,803 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	90,139,706 - 90,283,400 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Chrna7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624768	909,099 - 1,024,902 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624768	908,907 - 1,024,953 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003826048	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008951475	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034938458	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034938459	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034938460	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034938461	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034938462	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055098257	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063596513	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000029374 ⟹ ENSPPAP00000007226

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	15	29,565,885 - 29,705,194 (+)	Ensembl

Ensembl Acc Id:

ENSPPAT00000029378 ⟹ ENSPPAP00000007229

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	15	29,566,431 - 29,703,215 (+)	Ensembl

RefSeq Acc Id:

XM_003826048 ⟹ XP_003826096

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	16	20,841,680 - 20,981,068 (+)	NCBI
NHGRI_mPanPan1	15	25,565,746 - 25,705,121 (+)	NCBI
Mhudiblu_PPA_v0	15	10,525,541 - 10,667,227 (+)	NCBI
PanPan1.1	15	29,565,885 - 29,705,194 (+)	NCBI

Sequence:

show sequence

TCCTTAAAGGCGCGCGAGCCGAGCGGCGAGGTGCCTCTGTGGCCGCAGGCGCAGGCTCGGGCGA
CAGCCGAGACGTGGAGTGCGCCGGCTCGCTGCAGCTCCAGGACTCAACATGCGCTGCTCGCCGG
GAGGCGTCTGGCTGGCGCTGGCCGCGTCGCTCCTGCACGTGTCCCTGCAAGGCGAGTTCCAGAG
GAAGCTTTACAAGGAGCTGGTCAAGAACTACAATCCCTTGGAGAGGCCCGTGGCCAATGACTCG
CAACCGCTCACCGTCTACTTCTCCCTGAGCCTCCTGCAGATCATGGACGTGGATGAGAAGAACC
AAGTTTTAACCACCAACATTTGGCTGCAAATGTCTTGGACAGATCACTATTTACAGTGGAATGT
GTCAGAATATCCAGGGGTGAAGACTGTTCGTTTCCCAGATGGCCAGATTTGGAAACCAGACATT
CTTCTCTATAACAGTGCTGATGAGCGCTTTGACGCCACATTCCACACTAACGTGTTGGTGAATT
CTTCCGGGCATTGCCAGTACCTGCCTCCAGGCATATTCAAGAGTTCCTGCTACATCGATGTACG
CTGGTTTCCCTTTGATGTGCAGCACTGCAAACTGAAGTTTGGGTCCTGGTCTTACGGAGGCTGG
TCCTTGGATCTGCAGATGCAGGAGGCAGATATCAGTGGCTATATCCCCAATGGAGAATGGGACC
TAGTGGGAATCCCCGGCAAGAGGAGTGAAAGGTTCTATGAGTGCTGCAAAGAGCCCTACCCCGA
TGTCACCTTCACAGTGACCATGCGCCGCAGGACGCTCTACTATGGCCTCAACCTGCTGATCCCC
TGTGTGCTCATCTCCGCCCTCGCCCTGCTGGTGTTCCTGCTTCCTGCAGATTCCGGGGAGAAGA
TTTCCCTGGGGATAACAGTCTTACTCTCTCTTACTGTCTTCATGCTGCTCGTGGCTGAGATCAT
GCCTGCAACATCCGATTCGGTACCATTGATAGCCCAGTACTTCGCCAGCACCATGATCATCGTG
GGCCTCTCGGTGGTGGTGACAGTGATCGTGCTTCAGTACCACCACCACGACCCCGACGGGGGCA
AGATGCCCAAGTGGACCAGAGTCATCCTTCTGAACTGGTGCGCGTGGTTCCTGCGAATGAAGAG
GCCCGGGGAGGACAAGGTGCGCCCGGCCTGCCAGCACAAGCAGCGGCGCTGCAGCCTGGCCAGT
GTGGAGATGAGCGCCGTGGCGCCGCCGCCCGCCAGCAACGGGAACCTGCTGTACATCGGCTTCC
GCGGCCTGGACGGCGTGCACTGTGTCCCGACCCCCGACTCTGGGGTAGTGTGTGGCCGCATGGC
CTGCTCCCCCACGCACGACGAGCACCTCCTGCACGGTGGGCAGCCCCCCGAGGGGGACCCGGAC
CTGGCCAAGATCCTGGAGGAGGTCCGCTACATTGCCAACCGCTTCCGCTGCCAGGACGAAAGCG
AGGCGGTCTGCAGCGAGTGGAAGTTCGCCGCCTGCGTGGTGGACCGCCTGTGCCTCATGGCCTT
CTCGGTCTTCACCATCATCTGCACCATCGGCATCCTGATGTCGGCTCCCAACTTCGTGGAGGCC
GTGTCCAAAGACTTTGCGTAACCACGCCTGGTTCTGTACATGTGGAAAACTCACAGATGGGCAA
GGCCTTTGGCTTGGCGAGATTTGGGGGTGCTAATCCAGGACAGCATTACACGCCACAACTCCAG
TGTTCCCTTCTGGCTGTCAGTCGTGTTGCTTACGGTTTCTTTGTTACTTTAGGTAGTAGAATCT
CAGCACTTTGTTTCATATTCTCAGATGGGCTGATAGATATCCTTGGCACATCCGTACCATCGGT
CAGCAGGGCCACTGAGCAGTCATTTTGCCCATTAGCCCACTGCCTGGAAAGCCCTTCGGAGAGC
TCCCCATGGCTCCTCACCACCGGGACAGTTGGTTTTGCATGTCTGCATGAAGGTCTACCTGAAA
ATTCAACATTTGCTTTTTGCTTGTGTACAAACCCAGATTGAAGCTAAAATAAACCAGACTCACT
AAATCCATTCCAATAATTGACTGGTGGAAGGAAAACAAAAAACAAAAACTAAAAACCTCTTAGC
TTTTCTGCAATTCAACTTTTTATTTTTATTTCTATCAAAGACGGTAGAGAGAAACAGCTTGATG
CTGTTTCTACATTAAAAAAAAAAAAAAAAGACAGACTGTTGGTCTTACTAAGGATGTTTTTACC
AGCCTGCCTGACTTCTGCAAACCTACCCTGTCAAGGAGATCAAAGGGACGCAGGTTTCTGTTTA
TTCTGAACAAGGGCCAGGCCCCGCGGAGTGTCTTTGGTGGATCCCAGATAACTCCTAGGTGCTG
CTCTCAGACACTGAGGAGTTGAGCAAATCTGTTCTATTCTGCAGAACCCACAGGAAAAATAAGA
GTTCTACTAGAATTAACAGCCCAAAAGAATAGCTAAAGCTAAGTGAAGCCACTTACGTGGGCTT
TAAAAAAATAATGTGTTAGCTGATTCACATGCACTGGAGTTAATTAGTCTTAGAAATGTGTGCA
TCCATACAAATGCACAACATAAAGTGAACATATTCCTAGGCCCTTTCTGCCTGTGTCAGGGCCA
GGAAGTAGAGGCTGGGAACTCTTCTGGTCCCCAGTATGGCAGGCGCCAGGGAGGGGATGGTGTG
GCCCATCCCTTCTCTGGATACCTGGCCAGTGGCAGGCAGCAGGGAGGAGCTGGCCGACCCTCAG
TGACTGACAAGCCAGCAATTCTGAGTTCTGGCCTTTGGGAGTCTGCCTGCTCCAAGCCAGTCCA
CCCCAGCTGCAGCCCCAAAAGCTGGCTCAAAGTTCTTGGGTGGATTCACTGGAGATGGGCAACT
TAAAGCAAGAGAAACTTTAATTTTTAAACCTAAGTGATGATACAGCTCTTCCCTTAGATTATCG
CCCAGGCTGGAGTGCAGTGGCATGATCTCAGCTCACTGCAAGCTCCACCTCCTGGGTTCATGCC
ATTCTCCTGCCTCAGCCTCCCCCCGAGTAACTGGGAATACAGGCACCCGCCACCATGCCTGGCT
AATTTTTTGTATTTTTAGTAGAGATAGATAGGGTTTCATCATGTTAGCCAGGATGGTCTCATTC
TTATTCTTTAATGAGATCAGAGGGTAATTCACCAAGAAAGACCTCTCCTGTTCCATTGTGTCAT
CCAACAACTGCTCAGAGCTCAAAATTATAGAAGGCTTCTGAGCCCCTAGAGATTTTTAATTTGC
TTCTAATCCCTGAGGTGGGAACATCATGAGGGGAGATTTGATTTTCAGAGTTAAATAAATTGTA
TGTGCTTTTCCAGCCA

hide sequence

RefSeq Acc Id:

XM_034938459 ⟹ XP_034794350

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	16	20,929,227 - 20,981,068 (+)	NCBI
NHGRI_mPanPan1	15	25,653,278 - 25,705,121 (+)	NCBI
Mhudiblu_PPA_v0	15	10,613,162 - 10,667,227 (+)	NCBI

RefSeq Acc Id:

XM_055098257 ⟹ XP_054954232

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	16	20,842,134 - 20,981,068 (+)	NCBI
NHGRI_mPanPan1	15	25,566,201 - 25,705,121 (+)	NCBI

RefSeq Acc Id:

XM_063596513 ⟹ XP_063452583

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	16	20,841,679 - 20,981,068 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_003826096	(Get FASTA)	NCBI Sequence Viewer
	XP_034794350	(Get FASTA)	NCBI Sequence Viewer
	XP_054954232	(Get FASTA)	NCBI Sequence Viewer
	XP_063452583	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000007226.1
	ENSPPAP00000007229.1

RefSeq Acc Id:	XP_003826096 ⟸ XM_003826048
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R8ZQJ5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMD VDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHT NVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIP NGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPA DSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHH DPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNL LYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFR CQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA hide sequence

RefSeq Acc Id:	XP_034794350 ⟸ XM_034938459
- Peptide Label:	isoform X3

Ensembl Acc Id:

ENSPPAP00000007229 ⟸ ENSPPAT00000029378

Ensembl Acc Id:

ENSPPAP00000007226 ⟸ ENSPPAT00000029374

RefSeq Acc Id:	XP_054954232 ⟸ XM_055098257
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_063452583 ⟸ XM_063596513
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R8ZQJ5 (UniProtKB/TrEMBL)

Protein Domains

Neurotransmitter-gated ion-channel ligand-binding Neurotransmitter-gated ion-channel transmembrane

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000026369	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000029374.1	UniProtKB/TrEMBL
	ENSPPAT00000029378.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.58.390	UniProtKB/TrEMBL
	2.70.170.10	UniProtKB/TrEMBL
InterPro	Neur_chan_lig-bd	UniProtKB/TrEMBL
	Neur_chan_lig-bd_sf	UniProtKB/TrEMBL
	Neur_channel	UniProtKB/TrEMBL
	Neuro-gated_channel_TM_sf	UniProtKB/TrEMBL
	Neuro_actylchol_rec	UniProtKB/TrEMBL
	Neurotrans-gated_channel_TM	UniProtKB/TrEMBL
	Neurotransmitter_ion_chnl_CS	UniProtKB/TrEMBL
	Nicotinic_acetylcholine_rcpt	UniProtKB/TrEMBL
NCBI Gene	CHRNA7	ENTREZGENE
PANTHER	PTHR18945	UniProtKB/TrEMBL
Pfam	Neur_chan_LBD	UniProtKB/TrEMBL
	Neur_chan_memb	UniProtKB/TrEMBL
PRINTS	NICOTINICR	UniProtKB/TrEMBL
	NRIONCHANNEL	UniProtKB/TrEMBL
PROSITE	NEUROTR_ION_CHANNEL	UniProtKB/TrEMBL
Superfamily-SCOP	SSF63712	UniProtKB/TrEMBL
	SSF90112	UniProtKB/TrEMBL
UniProt	A0A2R8ZQJ5	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R8ZTQ2_PANPA	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2024-03-13	LOC100977072	neuronal acetylcholine receptor subunit alpha-7	CHRNA7	cholinergic receptor nicotinic alpha 7 subunit	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations