CCR6 (C-C motif chemokine receptor 6)

Advanced Search (OLGA)

Gene: CCR6 (C-C motif chemokine receptor 6) Pan paniscus

Analyze

Symbol:

CCR6

Name:

C-C motif chemokine receptor 6

RGD ID:

11861951

Description:

ENCODES a protein that exhibits C-C chemokine binding (inferred); C-C chemokine receptor activity (inferred); G protein-coupled receptor activity (inferred); INVOLVED IN DN2 thymocyte differentiation (ortholog); DN3 thymocyte differentiation (ortholog); isotype switching to IgA isotypes (ortholog); ASSOCIATED WITH allergic disease (ortholog); asthma (ortholog); atherosclerosis (ortholog); FOUND IN cell surface (inferred); external side of plasma membrane (inferred); membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

C-C chemokine receptor type 6

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	187,348,747 - 187,352,098 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	185,244,674 - 185,248,009 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	165,094,563 - 165,109,774 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	170,069,689 - 170,084,779 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	170,069,689 - 170,084,779 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

allergic disease (ISO)

asthma (ISO)

atherosclerosis (ISO)

breast cancer (ISO)

exanthem (ISO)

fungal infectious disease (ISO)

herpes simplex virus keratitis (ISO)

IgA glomerulonephritis (ISO)

invasive aspergillosis (ISO)

membranoproliferative glomerulonephritis (ISO)

Nasal Polyps (ISO)

Oral Lichen Planus (ISO)

pneumonia (ISO)

primary cutaneous T-cell non-Hodgkin lymphoma (ISO)

psoriasis (ISO)

rheumatoid arthritis (ISO)

systemic scleroderma (ISO)

transient cerebral ischemia (ISO)

ulcerative colitis (ISO)

vitiligo (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium-mediated signaling (IEA)

cell chemotaxis (IEA)

chemokine-mediated signaling pathway (IEA)

chemotaxis (IEA)

DN2 thymocyte differentiation (ISO)

DN3 thymocyte differentiation (ISO)

G protein-coupled receptor signaling pathway (IEA)

immune response (IEA)

isotype switching to IgA isotypes (ISO)

leukocyte migration involved in inflammatory response (ISO)

lymphocyte migration (ISO)

positive regulation of cytosolic calcium ion concentration (IEA,ISO)

positive regulation of dendritic cell chemotaxis (IEA,ISO)

positive regulation of epithelial cell migration (ISO)

positive regulation of flagellated sperm motility involved in capacitation (IEA)

regulation of T cell migration (ISO)

regulation of T-helper 17 cell differentiation (ISO)

T cell migration (ISO)

thymocyte migration (IEA)

Cellular Component

cell surface (IEA)

external side of plasma membrane (IEA)

membrane (IEA)

plasma membrane (IEA)

sperm flagellum (IEA)

sperm midpiece (IEA)

sperm plasma membrane (IEA)

sperm principal piece (IEA)

Molecular Function

C-C chemokine binding (IEA)

C-C chemokine receptor activity (IEA)

G protein-coupled receptor activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

CCR6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	187,348,747 - 187,352,098 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	185,244,674 - 185,248,009 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	165,094,563 - 165,109,774 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	170,069,689 - 170,084,779 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	170,069,689 - 170,084,779 (+)	Ensembl	panpan1.1		panPan2

CCR6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	167,111,795 - 167,139,141 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	167,111,807 - 167,139,141 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	167,525,283 - 167,552,629 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	167,445,285 - 167,472,619 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	167,506,667 - 167,523,040	NCBI
Celera	6	168,267,636 - 168,294,982 (+)	NCBI		Celera
Cytogenetic Map	6	q27	NCBI
HuRef	6	164,997,922 - 165,025,262 (+)	NCBI		HuRef
CHM1_1	6	167,787,685 - 167,815,011 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	168,494,454 - 168,521,816 (+)	NCBI		T2T-CHM13v2.0

Ccr6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	8,454,875 - 8,477,353 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	8,454,875 - 8,475,973 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	8,236,041 - 8,258,519 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	8,236,043 - 8,257,141 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	8,428,908 - 8,450,006 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	8,080,700 - 8,095,301 (+)	NCBI		MGSCv36	mm8
Celera	17	8,276,953 - 8,300,589 (+)	NCBI		Celera
Cytogenetic Map	17	A1	NCBI
cM Map	17	4.9	NCBI

Ccr6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	55,022,037 - 55,055,857 (-)	NCBI		GRCr8
mRatBN7.2	1	52,474,477 - 52,508,301 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	52,474,168 - 52,498,603 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	53,177,495 - 53,199,963 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	59,169,233 - 59,191,736 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	53,253,100 - 53,275,568 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	53,063,380 - 53,087,519 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	53,065,025 - 53,087,474 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	54,311,531 - 54,335,218 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	47,115,472 - 47,139,825 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	47,118,424 - 47,142,770 (-)	NCBI
Celera	1	48,238,928 - 48,261,505 (-)	NCBI		Celera
Cytogenetic Map	1	q12	NCBI

Ccr6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955439	14,920,601 - 14,924,191 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955439	14,921,524 - 14,949,493 (-)	NCBI	ChiLan1.0	ChiLan1.0

CCR6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	54,932,798 - 54,960,646 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	54,932,690 - 54,959,740 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	55,722,381 - 55,750,218 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	55,113,648 - 55,141,502 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	1	55,010,269 - 55,038,459 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	54,859,036 - 54,886,902 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	55,484,239 - 55,512,089 (+)	NCBI		UU_Cfam_GSD_1.0

Ccr6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	149,431,750 - 149,438,723 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936489	16,669,297 - 16,689,451 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936489	16,669,297 - 16,689,451 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CCR6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	2,018,608 - 2,019,821 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	2,016,600 - 2,034,172 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

CCR6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	94,865,480 - 94,894,331 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	94,865,936 - 94,894,315 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	66,673,826 - 66,688,967 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ccr6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624785	12,190,802 - 12,203,924 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003820220	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000048392 ⟹ ENSPPAP00000025564

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	6	170,069,689 - 170,084,779 (+)	Ensembl

RefSeq Acc Id:

XM_003820220 ⟹ XP_003820268

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	5	187,348,747 - 187,352,098 (+)	NCBI
NHGRI_mPanPan1	6	185,244,674 - 185,248,009 (+)	NCBI
Mhudiblu_PPA_v0	6	165,094,563 - 165,109,774 (+)	NCBI
PanPan1.1	6	170,069,689 - 170,084,779 (+)	NCBI

Sequence:

show sequence

AACTCACACGGCCTCTTGCAAACGTTCCCAAATCTTCCCAGTCGGCTTGCAGAGACTCCTTGCT
CCCAGGAGATAACCAGGTAAAGGAGTATGAAAGTTTGGGTACAAACTCATTGCTGCAAATTGAA
AACCATGCAAAGGCTGTCTTCCTCTGGGGAGCTCAATGCCTCTCTTTTTCTTATCACTTTACCA
TTGGTTGGACTTTGATTCCAGGGATCCTACGATTACTCAATACCCTACAGGATATACATGGTTA
ACCATTTGCATTTGGGCAAATAGGCGTTACTTTTCAATAGGAAGTGGCAATCCAGAACTTGCTT
TTGGGCAATTCTAGTAGCTCACCGCTTTTTTCTTAATGACTGCTAGAAGCTGCATCTTATTGAC
AGATGGTCATCACATTGGTGAGCTGGAGTCATCAGATTGTGGGGCCCGGAGTGAGGCTGAAGGG
AGTGGATCAGAGCACTGCCTGAGAGTCACTTCCACTTTCCTGCTACCGCTGCCTGTGAGCTGAA
GGGGCTGAACCATACACTCCTTTTTCTACAACCAGCTTGTATTTTTTCTGCCCACAATGAGCGG
GGAATCAATGAATTTCAGCGATGTTTTCGACTCCAGTGAAGATTATTTTGTGTCAGTCAATACT
TCATATTACTCAGTTGATTCTGAAACGTTACTGTGCTCCTTGCAGGAGGTCAGGCAGTTCTCCA
GGCTATTTGTACCGATTGCCTACTCCTTGATCTGTGTCTTTGGCCTCCTGGGGAATATTCTGGT
GGTGATCACCTTTGCTTTTTATAAGAAGGCCAGGTCTATGACAGACGTCTATCTCTTGAACATG
GCCATTGCAGACATCCTCTTTGTTCTTACTCTCCCATTCTGGGCAGTGAGTCATGCCACCGGTG
TGTGGGTTTTCAGCAATGCCACGTGCAAGTTGCTAAAAGGCATCTATGCCATCAACTTTAACTG
CGGGATGCTGCTCCTGACTTGCATTAGCATGGACCGGTACATCGCCATTGTACAGGCGACTAAG
TCATTCCGGCTCCGATCCAGAACACTACCGCGCAGCAAAATCATCTGCCTTGTTGTGTGGGGGC
TGTCAGTCATCATCTCCAGCTCAACTTTTGTCTTCAACCAGAAATACAACACCCAAGGCAGCGA
TGTCTGTGAACCCAAGTACCAGACTGTCTCGGAGCCCATCAGGTGGAAGCTGCTGATGTTGGGG
CTTGAGCTACTCTTTGGTTTCTTTATCCCTTTGATGTTCATGATATTTTGTTACACGTTCATTG
TCAAAACCTTGGTGCAAGCTCAGAATTCTAAAAGGCACAAAGCCATCCGTGTAATCATAGCCGT
GGTGCTTGTGTTTCTGGCTTGTCAGATTCCTCATAACATGGTCCTGCTTGTGACGGCTGCAAAT
TTGGGTAAAATGAACCGATCCTGCCAGAGCGAAAAGCTAATTGGCTATACGAAAACTGTCACAG
AAGTCCTGGCTTTCCTGCACTGCTGCCTGAACCCTGTGCTCTATGCTTTTATTGGGCAGAAGTT
CAGAAACTACTTTCTGAAGATCTTGAAGGACCTGTGGTGTGTGAGAAGGAAGTACAAGTCCTCA
GGCTTCTCCTGTGCCGGGAGGTACTCAGAAAACATTTCTCGGCAGACCAGTGAGACCGCAGATA
ACGACAATGCGTCGTCCTTCACTATGTGATAGAAAGCTGAGTCTCCCTAAGGCATGTGTGAAAC
ATACTCATAGATGTTATGCAAAAAAAAGTCTATGGCCAGGTATGCATGGAAAATGTGGGAATTA
AGCAAAATCAAGCAAGCGTCTCTCCTGCGGGACTTAACGTGCTCATGAGCTGTGTGATCTCTTC
AGGGTGGGGTGGTCTCTGATAGGTAGCATTTTCCAGCACTTTGCAAGGAATGTTTTGTTGCTCT
AGGGTATATATCCGCCTGGTGTTTCACAAAACAGCCTTTGGGAAATGCTGAATTAAGGTGAATT
GTTGACAAATGTAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003820268	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000025564
	ENSPPAP00000025564.1

RefSeq Acc Id:

XP_003820268 ⟸ XM_003820220

- UniProtKB:

A0A2R9B7I6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSGESMNFSDVFDSSEDYFVSVNTSYYSVDSETLLCSLQEVRQFSRLFVPIAYSLICVFGLLGN
ILVVITFAFYKKARSMTDVYLLNMAIADILFVLTLPFWAVSHATGVWVFSNATCKLLKGIYAIN
FNCGMLLLTCISMDRYIAIVQATKSFRLRSRTLPRSKIICLVVWGLSVIISSSTFVFNQKYNTQ
GSDVCEPKYQTVSEPIRWKLLMLGLELLFGFFIPLMFMIFCYTFIVKTLVQAQNSKRHKAIRVI
IAVVLVFLACQIPHNMVLLVTAANLGKMNRSCQSEKLIGYTKTVTEVLAFLHCCLNPVLYAFIG
QKFRNYFLKILKDLWCVRRKYKSSGFSCAGRYSENISRQTSETADNDNASSFTM

hide sequence

Ensembl Acc Id:

ENSPPAP00000025564 ⟸ ENSPPAT00000048392

Protein Domains

G-protein coupled receptors family 1 profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000035908	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000048392.1	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	Chemokine_CCR6	UniProtKB/TrEMBL
	Chemokine_rcpt	UniProtKB/TrEMBL
	GPCR1	UniProtKB/TrEMBL
	GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/TrEMBL
KEGG Report	pps:100970325	UniProtKB/TrEMBL
NCBI Gene	CCR6	ENTREZGENE
PANTHER	CELL ADHESION MOLECULE	UniProtKB/TrEMBL
	PTHR10489:SF611	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PRINTS	CCCHEMOKINER	UniProtKB/TrEMBL
	CHEMOKINER6	UniProtKB/TrEMBL
	GPCRRHODOPSN	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	A0A2R9B7I6	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - CTD