CPOX (coproporphyrinogen oxidase) - Rat Genome Database

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Gene: CPOX (coproporphyrinogen oxidase) Pan paniscus
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Symbol: CPOX
Name: coproporphyrinogen oxidase
RGD ID: 11852674
Description: ENCODES a protein that exhibits coproporphyrinogen oxidase activity (ortholog); identical protein binding (ortholog); INVOLVED IN heme biosynthetic process (ortholog); protoporphyrinogen IX biosynthetic process (ortholog); response to arsenic-containing substance (ortholog); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; heme biosynthetic pathway; ASSOCIATED WITH acute intermittent porphyria (ortholog); Experimental Arthritis (ortholog); genetic disease (ortholog); FOUND IN mitochondrial inner membrane (ortholog); mitochondrial intermembrane space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2296,505,625 - 96,529,606 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1396,510,420 - 96,534,386 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0395,674,861 - 95,689,139 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13102,358,149 - 102,372,323 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3102,359,382 - 102,372,170 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CPOX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2296,505,625 - 96,529,606 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1396,510,420 - 96,534,386 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0395,674,861 - 95,689,139 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13102,358,149 - 102,372,323 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3102,359,382 - 102,372,170 (-)Ensemblpanpan1.1panPan2
CPOX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38398,570,488 - 98,593,611 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl398,579,446 - 98,593,648 (-)EnsemblGRCh38hg38GRCh38
GRCh37398,298,290 - 98,312,455 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36399,780,980 - 99,795,131 (-)NCBINCBI36Build 36hg18NCBI36
Build 34399,780,981 - 99,795,131NCBI
Celera396,689,942 - 96,704,107 (-)NCBICelera
Cytogenetic Map3q11.2NCBI
HuRef395,670,419 - 95,684,588 (-)NCBIHuRef
CHM1_1398,261,466 - 98,275,631 (-)NCBICHM1_1
T2T-CHM13v2.03101,272,112 - 101,297,297 (-)NCBIT2T-CHM13v2.0
Cpox
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391658,490,571 - 58,500,754 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1658,490,655 - 58,537,999 (+)EnsemblGRCm39 Ensembl
GRCm381658,670,208 - 58,680,391 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1658,670,292 - 58,717,636 (+)EnsemblGRCm38mm10GRCm38
MGSCv371658,670,321 - 58,680,504 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361658,612,835 - 58,622,904 (+)NCBIMGSCv36mm8
Celera1658,961,121 - 58,971,379 (+)NCBICelera
Cytogenetic Map16C1.2NCBI
Cpox
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81155,405,778 - 55,415,761 (-)NCBIGRCr8
mRatBN7.21141,936,585 - 41,946,568 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1141,936,591 - 41,946,746 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1150,684,226 - 50,694,252 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01143,345,792 - 43,355,818 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01142,474,428 - 42,484,454 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01144,039,665 - 44,049,648 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1144,039,669 - 44,049,648 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01147,229,581 - 47,239,564 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41142,748,703 - 42,758,686 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11142,807,556 - 42,935,211 (-)NCBI
Celera1141,735,836 - 41,745,819 (-)NCBICelera
Cytogenetic Map11q12NCBI
Cpox
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955427152,894 - 164,030 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955427152,397 - 163,570 (-)NCBIChiLan1.0ChiLan1.0
CPOX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1335,446,022 - 5,459,152 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl335,447,414 - 5,459,461 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha335,596,705 - 5,613,382 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0335,579,096 - 5,595,946 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl335,535,265 - 5,595,946 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1335,456,702 - 5,473,645 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0335,519,969 - 5,536,809 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0335,796,805 - 5,813,754 (-)NCBIUU_Cfam_GSD_1.0
Cpox
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602151,514,512 - 151,526,977 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366304,412,273 - 4,425,520 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366304,412,099 - 4,424,867 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CPOX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13160,332,436 - 160,348,232 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113160,332,436 - 160,345,862 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213170,521,920 - 170,535,349 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CPOX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12282,252,163 - 82,265,827 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2282,251,972 - 82,267,350 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604184,286,976 - 84,301,373 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cpox
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478911,435,779 - 11,448,984 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478911,435,955 - 11,448,867 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000060158   ⟹   ENSPPAP00000037258
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl3102,359,382 - 102,372,170 (-)Ensembl
RefSeq Acc Id: XM_008975378   ⟹   XP_008973626
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2296,515,318 - 96,529,601 (-)NCBI
NHGRI_mPanPan1396,520,102 - 96,534,382 (-)NCBI
Mhudiblu_PPA_v0395,674,861 - 95,689,139 (-)NCBI
PanPan1.13102,358,149 - 102,372,323 (-)NCBI
Sequence:
RefSeq Acc Id: XM_055110196   ⟹   XP_054966171
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2296,505,625 - 96,529,606 (-)NCBI
NHGRI_mPanPan1396,510,420 - 96,534,386 (-)NCBI
RefSeq Acc Id: XM_063602483   ⟹   XP_063458553
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2296,515,318 - 96,529,603 (-)NCBI
Protein Sequences
Protein RefSeqs XP_008973626 (Get FASTA)   NCBI Sequence Viewer  
  XP_054966171 (Get FASTA)   NCBI Sequence Viewer  
  XP_063458553 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000037258.1
RefSeq Acc Id: XP_008973626   ⟸   XM_008975378
- Peptide Label: isoform X1
- UniProtKB: A0A2R9C8J2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000037258   ⟸   ENSPPAT00000060158
RefSeq Acc Id: XP_054966171   ⟸   XM_055110196
- Peptide Label: isoform X3
- UniProtKB: A0A2R9C8J2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063458553   ⟸   XM_063602483
- Peptide Label: isoform X2
- UniProtKB: A0A2R9C8J2 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000041386 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000060158.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1500.10 UniProtKB/TrEMBL
InterPro Coprogen_oxidase_aer UniProtKB/TrEMBL
  Coprogen_oxidase_aer_sf UniProtKB/TrEMBL
  Coprogen_oxidase_CS UniProtKB/TrEMBL
NCBI Gene CPOX ENTREZGENE
PANTHER OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR10755 UniProtKB/TrEMBL
Pfam Coprogen_oxidas UniProtKB/TrEMBL
PRINTS COPRGNOXDASE UniProtKB/TrEMBL
PROSITE COPROGEN_OXIDASE UniProtKB/TrEMBL
Superfamily-SCOP SSF102886 UniProtKB/TrEMBL
UniProt A0A2R9C8J2 ENTREZGENE, UniProtKB/TrEMBL