AKR1C3 (aldo-keto reductase family 1 member C3) - Rat Genome Database

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Gene: AKR1C3 (aldo-keto reductase family 1 member C3) Pan paniscus
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Symbol: AKR1C3
Name: aldo-keto reductase family 1 member C3
RGD ID: 11811002
Description: ENCODES a protein that exhibits 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity (ortholog); aldo-keto reductase (NADPH) activity (ortholog); aldose reductase (NADPH) activity (ortholog); INVOLVED IN cellular response to follicle-stimulating hormone stimulus (ortholog); cellular response to forskolin (ortholog); cellular response to gonadotropin-releasing hormone (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); B-lymphoblastic leukemia/lymphoma (ortholog); castration-resistant prostate carcinoma (ortholog); FOUND IN cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II); LOC100986388
RGD Orthologs
Human
Mouse
Rat
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2817,590,820 - 17,668,960 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11017,660,905 - 17,732,534 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0105,079,580 - 5,157,572 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1105,061,119 - 5,139,818 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl105,081,214 - 5,139,812 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to calcium ion  (IEA)
cellular response to corticosteroid stimulus  (IEA)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to forskolin  (ISO)
cellular response to gonadotropin-releasing hormone  (ISO)
cellular response to jasmonic acid stimulus  (IEA)
cellular response to prolactin  (ISO)
cellular response to prostaglandin D stimulus  (IEA)
cellular response to prostaglandin stimulus  (IEA)
cellular response to starvation  (IEA)
cellular response to testosterone stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
daunorubicin metabolic process  (IEA)
doxorubicin metabolic process  (IEA)
farnesol catabolic process  (IEA)
female pregnancy  (ISO)
G protein-coupled receptor signaling pathway  (IEA)
keratinocyte differentiation  (IEA)
male gonad development  (IEA)
negative regulation of retinoic acid biosynthetic process  (IEA)
parturition  (ISO)
positive regulation of cell population proliferation  (IEA)
positive regulation of endothelial cell apoptotic process  (IEA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of reactive oxygen species metabolic process  (IEA)
progesterone catabolic process  (ISO)
progesterone metabolic process  (IEA,ISO)
prostaglandin metabolic process  (IEA)
regulation of retinoic acid receptor signaling pathway  (IEA)
regulation of steroid biosynthetic process  (ISO)
regulation of testosterone biosynthetic process  (IEA)
response to nutrient  (IEA)
retinal metabolic process  (IEA)
steroid metabolic process  (IEA)
testosterone biosynthetic process  (IEA)

Cellular Component
cytoplasm  (IEA)
cytosol  (ISO)
nucleus  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
AKR1C3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2817,590,820 - 17,668,960 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11017,660,905 - 17,732,534 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0105,079,580 - 5,157,572 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1105,061,119 - 5,139,818 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl105,081,214 - 5,139,812 (+)Ensemblpanpan1.1panPan2
AKR1C3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38105,048,781 - 5,107,686 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl105,035,354 - 5,107,686 (+)EnsemblGRCh38hg38GRCh38
GRCh37105,090,973 - 5,149,878 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36105,126,568 - 5,139,878 (+)NCBINCBI36Build 36hg18NCBI36
Build 34105,126,567 - 5,139,878NCBI
Celera105,076,549 - 5,089,836 (+)NCBICelera
Cytogenetic Map10p15.1NCBI
HuRef105,024,814 - 5,083,613 (+)NCBIHuRef
CHM1_1105,091,312 - 5,150,193 (+)NCBICHM1_1
T2T-CHM13v2.0105,049,294 - 5,108,188 (+)NCBIT2T-CHM13v2.0
Akr1c18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39134,182,614 - 4,200,645 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl134,182,614 - 4,200,653 (-)EnsemblGRCm39 Ensembl
GRCm38134,132,615 - 4,150,646 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl134,132,615 - 4,150,654 (-)EnsemblGRCm38mm10GRCm38
MGSCv37134,131,873 - 4,149,877 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36134,131,873 - 4,149,877 (-)NCBIMGSCv36mm8
Celera134,108,614 - 4,126,601 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map132.31NCBI
Akr1c3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81771,020,884 - 71,037,779 (+)NCBIGRCr8
mRatBN7.21766,110,970 - 66,127,867 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1766,110,963 - 66,127,873 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1769,596,139 - 69,613,038 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01773,424,984 - 73,441,883 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01767,467,962 - 67,484,861 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01769,761,126 - 69,778,021 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1769,761,118 - 69,778,021 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01771,465,942 - 71,482,837 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41777,269,626 - 77,286,521 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11777,280,458 - 77,297,354 (+)NCBI
Celera1765,626,116 - 65,643,004 (+)NCBICelera
Cytogenetic Map17q12.2NCBI
AKR1C3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1230,661,333 - 30,691,283 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl230,674,558 - 30,690,043 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha227,694,812 - 27,719,595 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0231,042,072 - 31,071,570 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl231,045,998 - 31,070,795 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1228,135,405 - 28,160,172 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0228,972,376 - 28,997,157 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0229,696,602 - 29,721,383 (+)NCBIUU_Cfam_GSD_1.0
AKR1C1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1065,576,464 - 65,678,248 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11065,580,297 - 65,594,998 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21071,833,237 - 71,847,948 (+)NCBISscrofa10.2Sscrofa10.2susScr3


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000033417   ⟹   ENSPPAP00000010763
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl105,081,214 - 5,139,635 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000033419   ⟹   ENSPPAP00000010765
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl105,110,200 - 5,139,635 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000033426   ⟹   ENSPPAP00000010772
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl105,126,476 - 5,139,812 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000033427   ⟹   ENSPPAP00000010773
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl105,127,915 - 5,139,635 (+)Ensembl
RefSeq Acc Id: XM_034929874   ⟹   XP_034785765
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2817,590,885 - 17,668,960 (+)NCBI
NHGRI_mPanPan11017,660,905 - 17,676,192 (+)NCBI
Mhudiblu_PPA_v0105,127,860 - 5,157,572 (+)NCBI
RefSeq Acc Id: XM_063607233   ⟹   XP_063463303
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2817,590,885 - 17,668,723 (+)NCBI
RefSeq Acc Id: XM_063607234   ⟹   XP_063463304
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2817,590,885 - 17,668,960 (+)NCBI
RefSeq Acc Id: XM_063607235   ⟹   XP_063463305
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2817,590,844 - 17,668,724 (+)NCBI
RefSeq Acc Id: XM_063607236   ⟹   XP_063463306
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2817,590,893 - 17,668,724 (+)NCBI
RefSeq Acc Id: XM_063607237   ⟹   XP_063463307
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2817,590,820 - 17,668,960 (+)NCBI
RefSeq Acc Id: XM_063607238   ⟹   XP_063463308
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2817,590,844 - 17,668,960 (+)NCBI
RefSeq Acc Id: XP_034785765   ⟸   XM_034929874
- Peptide Label: isoform X2
- UniProtKB: A0A2R9A0L9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000010772   ⟸   ENSPPAT00000033426
Ensembl Acc Id: ENSPPAP00000010773   ⟸   ENSPPAT00000033427
Ensembl Acc Id: ENSPPAP00000010765   ⟸   ENSPPAT00000033419
Ensembl Acc Id: ENSPPAP00000010763   ⟸   ENSPPAT00000033417
RefSeq Acc Id: XP_063463307   ⟸   XM_063607237
- Peptide Label: isoform X4
- UniProtKB: A0A2R9A618 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063463308   ⟸   XM_063607238
- Peptide Label: isoform X4
- UniProtKB: A0A2R9A618 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063463305   ⟸   XM_063607235
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063463304   ⟸   XM_063607234
- Peptide Label: isoform X2
- UniProtKB: A0A2R9A0L9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063463303   ⟸   XM_063607233
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063463306   ⟸   XM_063607236
- Peptide Label: isoform X3
Protein Domains
NADP-dependent oxidoreductase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000028592 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000033417.1 UniProtKB/TrEMBL
  ENSPPAT00000033419.1 UniProtKB/TrEMBL
  ENSPPAT00000033426.1 UniProtKB/TrEMBL
  ENSPPAT00000033427.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.100 UniProtKB/TrEMBL
InterPro AKR UniProtKB/TrEMBL
  AKR1C UniProtKB/TrEMBL
  Aldo/ket_reductase_CS UniProtKB/TrEMBL
  NADP_OxRdtase_dom UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/TrEMBL
NCBI Gene LOC100986388 ENTREZGENE
PANTHER ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 UniProtKB/TrEMBL
  ALDO/KETO REDUCTASE UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/TrEMBL
PIRSF AKR UniProtKB/TrEMBL
PRINTS ALDKETRDTASE UniProtKB/TrEMBL
PROSITE ALDOKETO_REDUCTASE_1 UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_2 UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF51430 UniProtKB/TrEMBL
UniProt A0A2R9A0L9 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9A1P7_PANPA UniProtKB/TrEMBL
  A0A2R9A1Q5_PANPA UniProtKB/TrEMBL
  A0A2R9A618 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-03-13 AKR1C3  aldo-keto reductase family 1 member C3  LOC100986388  aldo-keto reductase family 1 member C3  Symbol and/or name change 5135510 APPROVED