RUVBL2 (RuvB like AAA ATPase 2) - Rat Genome Database

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Gene: RUVBL2 (RuvB like AAA ATPase 2) Pan paniscus
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Symbol: RUVBL2
Name: RuvB like AAA ATPase 2
RGD ID: 11797306
Description: ENCODES a protein that exhibits ADP binding (ortholog); ATPase binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN positive regulation of DNA repair (ortholog); positive regulation of telomere maintenance in response to DNA damage (ortholog); regulation of DNA repair (ortholog); PARTICIPATES IN INO80 family mediated chromatin remodeling pathway; ASSOCIATED WITH progressive familial heart block type IB (ortholog); FOUND IN ribonucleoprotein complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: RuvB-like 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,099,261 - 55,121,683 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11957,025,412 - 57,047,842 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01945,995,394 - 46,017,835 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11954,739,474 - 54,761,407 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1954,739,474 - 54,761,407 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
RUVBL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,099,261 - 55,121,683 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11957,025,412 - 57,047,842 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01945,995,394 - 46,017,835 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11954,739,474 - 54,761,407 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1954,739,474 - 54,761,407 (-)Ensemblpanpan1.1panPan2
RUVBL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,993,448 - 49,015,995 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1948,993,562 - 49,015,970 (+)EnsemblGRCh38hg38GRCh38
GRCh371949,496,705 - 49,519,252 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,188,968 - 54,210,994 (+)NCBINCBI36Build 36hg18NCBI36
Build 341954,188,967 - 54,210,994NCBI
Celera1946,364,487 - 46,386,389 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,873,862 - 45,895,902 (+)NCBIHuRef
CHM1_11949,499,385 - 49,521,406 (+)NCBICHM1_1
T2T-CHM13v2.01951,988,347 - 52,010,769 (+)NCBIT2T-CHM13v2.0
Ruvbl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,071,320 - 45,084,817 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,071,184 - 45,087,520 (-)EnsemblGRCm39 Ensembl
GRCm38745,421,896 - 45,436,171 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,421,760 - 45,438,096 (-)EnsemblGRCm38mm10GRCm38
MGSCv37752,677,268 - 52,689,834 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,290,000 - 45,302,337 (-)NCBIMGSCv36mm8
Celera740,877,932 - 40,890,498 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.3NCBI
Ruvbl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,038,487 - 105,051,851 (-)NCBIGRCr8
mRatBN7.2195,902,014 - 95,915,247 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,901,701 - 95,915,342 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,287,438 - 101,300,671 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,760,116 - 109,773,349 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,050,515 - 103,063,748 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,413,766 - 101,426,970 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,413,766 - 101,426,852 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,493,176 - 102,506,380 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,894,029 - 95,906,885 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1195,972,140 - 95,985,010 (-)NCBI
Celera190,157,605 - 90,170,691 (-)NCBICelera
Cytogenetic Map1q22NCBI
Ruvbl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,654,059 - 1,674,272 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,657,241 - 1,674,272 (-)NCBIChiLan1.0ChiLan1.0
RUVBL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,384,328 - 107,400,849 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,384,342 - 107,400,505 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1106,910,707 - 106,923,430 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01107,908,904 - 107,925,482 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,908,893 - 107,925,182 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,576,740 - 107,593,066 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,222,909 - 107,239,405 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,058,521 - 108,075,019 (-)NCBIUU_Cfam_GSD_1.0
Ruvbl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,377,118 - 21,392,373 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366642,995,213 - 3,010,853 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366642,995,212 - 3,010,563 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RUVBL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,250,515 - 54,266,893 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,250,494 - 54,263,492 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,065,154 - 50,078,153 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RUVBL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,227,982 - 42,247,204 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl642,227,821 - 42,249,707 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607322,110,661 - 22,134,370 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ruvbl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248325,014,484 - 5,028,885 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248325,014,484 - 5,028,868 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000053597   ⟹   ENSPPAP00000030733
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1954,739,474 - 54,761,407 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000053619   ⟹   ENSPPAP00000030755
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1954,739,754 - 54,750,861 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000053631   ⟹   ENSPPAP00000030767
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1954,750,914 - 54,755,689 (-)Ensembl
RefSeq Acc Id: XM_003814292   ⟹   XP_003814340
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22055,099,261 - 55,121,683 (+)NCBI
NHGRI_mPanPan11957,025,412 - 57,047,842 (+)NCBI
Mhudiblu_PPA_v01945,995,573 - 46,017,835 (+)NCBI
PanPan1.11954,739,474 - 54,761,407 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034945083   ⟹   XP_034800974
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22055,099,639 - 55,121,683 (+)NCBI
NHGRI_mPanPan11957,025,790 - 57,047,842 (+)NCBI
Mhudiblu_PPA_v01945,995,394 - 46,017,835 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003814340 (Get FASTA)   NCBI Sequence Viewer  
  XP_034800974 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000030733.1
  ENSPPAP00000030755.1
  ENSPPAP00000030767.1
RefSeq Acc Id: XP_003814340   ⟸   XM_003814292
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BQN2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034800974   ⟸   XM_034945083
- Peptide Label: isoform X2
Ensembl Acc Id: ENSPPAP00000030767   ⟸   ENSPPAT00000053631
Ensembl Acc Id: ENSPPAP00000030755   ⟸   ENSPPAT00000053619
Ensembl Acc Id: ENSPPAP00000030733   ⟸   ENSPPAT00000053597
Protein Domains
AAA+ ATPase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000038265 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000053597.1 UniProtKB/TrEMBL
  ENSPPAT00000053619.1 UniProtKB/TrEMBL
  ENSPPAT00000053631.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.8.60 UniProtKB/TrEMBL
  2.40.50.360 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  RuvB-like UniProtKB/TrEMBL
  RuvB-like_C UniProtKB/TrEMBL
  RuvBL1/2_DNA/RNA_bd_dom UniProtKB/TrEMBL
  TIP49_P-loop UniProtKB/TrEMBL
KEGG Report pps:100990812 UniProtKB/TrEMBL
NCBI Gene RUVBL2 ENTREZGENE
PANTHER PTHR11093 UniProtKB/TrEMBL
Pfam TIP49 UniProtKB/TrEMBL
  TIP49_C UniProtKB/TrEMBL
PRINTS DNAREPAIRADA UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A2R9BM44_PANPA UniProtKB/TrEMBL
  A0A2R9BQN2 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BW67_PANPA UniProtKB/TrEMBL