GHRL (ghrelin and obestatin prepropeptide) - Rat Genome Database

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Gene: GHRL (ghrelin and obestatin prepropeptide) Pan paniscus
Analyze
Symbol: GHRL
Name: ghrelin and obestatin prepropeptide
RGD ID: 11789485
Description: ENCODES a protein that exhibits G protein-coupled receptor binding (ortholog); ghrelin receptor binding (ortholog); growth hormone-releasing hormone activity (ortholog); INVOLVED IN adult feeding behavior (ortholog); dendrite development (ortholog); excitatory postsynaptic potential (ortholog); PARTICIPATES IN ghrelin system pathway; ASSOCIATED WITH acute kidney failure (ortholog); adenocarcinoma (ortholog); Atrioventricular Septal Defect 2 (ortholog); FOUND IN glutamatergic synapse (ortholog); neuronal dense core vesicle lumen (ortholog); Schaffer collateral - CA1 synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: appetite-regulating hormone
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2210,281,654 - 10,288,926 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1310,286,078 - 10,301,544 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0310,221,829 - 10,229,229 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1310,573,537 - 10,580,723 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl310,573,537 - 10,580,723 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin polymerization or depolymerization  (IEA)
adult feeding behavior  (ISO)
decidualization  (IEA)
dendrite development  (IEA,ISO)
excitatory postsynaptic potential  (IEA,ISO)
G protein-coupled receptor signaling pathway  (ISO)
gastric acid secretion  (IEA)
negative regulation of apoptotic process  (IEA)
negative regulation of circadian sleep/wake cycle, REM sleep  (IEA)
negative regulation of endothelial cell proliferation  (IEA)
negative regulation of inflammatory response  (IEA)
negative regulation of insulin secretion  (IEA,ISO)
negative regulation of interleukin-1 beta production  (IEA,ISO)
negative regulation of interleukin-6 production  (IEA)
negative regulation of locomotion  (IEA,ISO)
negative regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of adipose tissue development  (ISO)
positive regulation of appetite  (IEA,ISO)
positive regulation of bone development  (ISO)
positive regulation of circadian sleep/wake cycle, non-REM sleep  (IEA)
positive regulation of cold-induced thermogenesis  (IEA)
positive regulation of corticotropin secretion  (IEA)
positive regulation of cortisol secretion  (IEA)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of eating behavior  (ISO)
positive regulation of feeding behavior  (ISO)
positive regulation of gastric mucosal blood circulation  (ISO)
positive regulation of gastro-intestinal system smooth muscle contraction  (ISO)
positive regulation of growth  (ISO)
positive regulation of growth hormone secretion  (IEA)
positive regulation of growth rate  (ISO)
positive regulation of insulin secretion  (IEA)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of MAPK cascade  (IEA)
positive regulation of response to food  (ISO)
positive regulation of small intestinal transit  (ISO)
positive regulation of small intestine smooth muscle contraction  (ISO)
positive regulation of sprouting angiogenesis  (ISO)
positive regulation of synapse assembly  (IEA,ISO)
positive regulation of vascular endothelial cell proliferation  (ISO)
postsynaptic modulation of chemical synaptic transmission  (ISO)
regulation of cell population proliferation  (IEA)
regulation of gastric motility  (ISO)
regulation of postsynapse organization  (ISO)
regulation of response to food  (IEA,ISO)
regulation of transmission of nerve impulse  (ISO)
response to electrical stimulus  (ISO)
response to estrogen  (IEA)
response to hormone  (IEA)
response to nutrient levels  (ISO)
signal transduction  (IEA)
synapse assembly  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GHRL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2210,281,654 - 10,288,926 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1310,286,078 - 10,301,544 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0310,221,829 - 10,229,229 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1310,573,537 - 10,580,723 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl310,573,537 - 10,580,723 (-)Ensemblpanpan1.1panPan2
GHRL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38310,285,666 - 10,292,947 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl310,285,666 - 10,292,947 (-)EnsemblGRCh38hg38GRCh38
GRCh37310,327,350 - 10,334,631 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36310,302,434 - 10,307,409 (-)NCBINCBI36Build 36hg18NCBI36
Build 34310,302,433 - 10,307,409NCBI
Celera310,263,242 - 10,270,439 (-)NCBICelera
Cytogenetic Map3p25.3NCBI
HuRef310,262,844 - 10,269,999 (-)NCBIHuRef
CHM1_1310,277,571 - 10,284,767 (-)NCBICHM1_1
T2T-CHM13v2.0310,278,965 - 10,286,246 (-)NCBIT2T-CHM13v2.0
Ghrl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396113,693,080 - 113,696,872 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6113,693,080 - 113,696,841 (-)EnsemblGRCm39 Ensembl
GRCm386113,716,119 - 113,719,911 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6113,716,119 - 113,719,880 (-)EnsemblGRCm38mm10GRCm38
MGSCv376113,666,113 - 113,669,874 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366113,681,896 - 113,685,657 (-)NCBIMGSCv36mm8
Celera6115,541,628 - 115,545,391 (-)NCBICelera
Cytogenetic Map6E3NCBI
cM Map652.84NCBI
Ghrl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84148,421,315 - 148,431,128 (-)NCBIGRCr8
mRatBN7.24146,865,712 - 146,869,621 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4146,865,712 - 146,869,621 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4152,250,366 - 152,254,274 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04148,031,237 - 148,035,145 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04146,659,480 - 146,663,373 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04145,674,157 - 145,678,066 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4145,674,157 - 145,678,066 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04208,969,963 - 208,976,778 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44149,622,566 - 149,628,111 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14149,867,406 - 149,872,952 (-)NCBI
Celera4135,420,041 - 135,423,946 (-)NCBICelera
Cytogenetic Map4q42NCBI
Ghrl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555611,676,576 - 1,681,812 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555611,676,475 - 1,682,205 (-)NCBIChiLan1.0ChiLan1.0
GHRL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1208,092,921 - 8,097,512 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl208,092,957 - 8,097,510 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha208,127,316 - 8,131,869 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0208,122,116 - 8,127,217 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl208,122,662 - 8,127,215 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1207,844,540 - 7,849,093 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0208,190,266 - 8,194,819 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0208,163,907 - 8,168,460 (+)NCBIUU_Cfam_GSD_1.0
Ghrl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494215,867,085 - 15,872,024 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366023,038,549 - 3,042,506 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366023,037,862 - 3,044,863 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GHRL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1366,445,992 - 66,452,917 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11366,442,106 - 66,453,576 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21373,453,082 - 73,480,182 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap13q31NCBI
GHRL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12246,326,458 - 46,332,906 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2246,325,913 - 46,330,962 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041120,205,064 - 120,210,786 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ghrl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247315,257,830 - 5,262,473 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247315,257,813 - 5,262,878 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000030157   ⟹   ENSPPAP00000007638
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl310,573,537 - 10,580,723 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000030160   ⟹   ENSPPAP00000007641
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl310,573,631 - 10,580,689 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000030164   ⟹   ENSPPAP00000007643
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl310,573,631 - 10,577,954 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000030167   ⟹   ENSPPAP00000007645
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl310,573,662 - 10,580,689 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000030168   ⟹   ENSPPAP00000007646
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl310,573,662 - 10,580,689 (-)Ensembl
RefSeq Acc Id: XM_003826287   ⟹   XP_003826335
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2210,281,654 - 10,288,829 (-)NCBI
NHGRI_mPanPan1310,286,096 - 10,293,589 (-)NCBI
Mhudiblu_PPA_v0310,221,829 - 10,229,018 (-)NCBI
PanPan1.1310,573,537 - 10,580,718 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003826288   ⟹   XP_003826336
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2210,281,654 - 10,288,846 (-)NCBI
NHGRI_mPanPan1310,286,096 - 10,293,606 (-)NCBI
Mhudiblu_PPA_v0310,221,829 - 10,229,022 (-)NCBI
PanPan1.1310,573,537 - 10,580,723 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024928099   ⟹   XP_024783867
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2210,281,654 - 10,288,832 (-)NCBI
NHGRI_mPanPan1310,286,096 - 10,293,592 (-)NCBI
Mhudiblu_PPA_v0310,221,829 - 10,229,008 (-)NCBI
PanPan1.1310,573,537 - 10,580,668 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034955765   ⟹   XP_034811656
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2210,281,654 - 10,288,926 (-)NCBI
NHGRI_mPanPan1310,286,089 - 10,294,009 (-)NCBI
Mhudiblu_PPA_v0310,221,829 - 10,229,222 (-)NCBI
RefSeq Acc Id: XM_034955767   ⟹   XP_034811658
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2210,281,654 - 10,288,826 (-)NCBI
NHGRI_mPanPan1310,286,096 - 10,293,586 (-)NCBI
Mhudiblu_PPA_v0310,221,829 - 10,229,002 (-)NCBI
RefSeq Acc Id: XM_034955770   ⟹   XP_034811661
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2210,281,654 - 10,288,846 (-)NCBI
NHGRI_mPanPan1310,286,086 - 10,293,606 (-)NCBI
Mhudiblu_PPA_v0310,221,829 - 10,229,022 (-)NCBI
RefSeq Acc Id: XP_003826335   ⟸   XM_003826287
- Peptide Label: isoform X2
- UniProtKB: A0A2R8ZSX1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003826336   ⟸   XM_003826288
- Peptide Label: isoform X2
- UniProtKB: A0A2R8ZSX1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024783867   ⟸   XM_024928099
- Peptide Label: isoform X2
- UniProtKB: A0A2R8ZSX1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034811656   ⟸   XM_034955765
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034811661   ⟸   XM_034955770
- Peptide Label: isoform X3
- UniProtKB: A0A2R8ZXJ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034811658   ⟸   XM_034955767
- Peptide Label: isoform X2
- UniProtKB: A0A2R8ZSX1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000007638   ⟸   ENSPPAT00000030157
Ensembl Acc Id: ENSPPAP00000007645   ⟸   ENSPPAT00000030167
Ensembl Acc Id: ENSPPAP00000007646   ⟸   ENSPPAT00000030168
Ensembl Acc Id: ENSPPAP00000007641   ⟸   ENSPPAT00000030160
Ensembl Acc Id: ENSPPAP00000007643   ⟸   ENSPPAT00000030164
Protein Domains
Motilin/ghrelin   Motilin/ghrelin-associated peptide


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000026950 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000030157.1 UniProtKB/TrEMBL
  ENSPPAT00000030160.1 UniProtKB/TrEMBL
  ENSPPAT00000030164.1 UniProtKB/TrEMBL
  ENSPPAT00000030167.1 UniProtKB/TrEMBL
  ENSPPAT00000030168.1 UniProtKB/TrEMBL
InterPro Motilin_assoc UniProtKB/TrEMBL
  Motilin_ghrelin UniProtKB/TrEMBL
  Preproghrelin UniProtKB/TrEMBL
KEGG Report pps:100984734 UniProtKB/TrEMBL
NCBI Gene GHRL ENTREZGENE
PANTHER APPETITE-REGULATING HORMONE UniProtKB/TrEMBL
  PTHR14122 UniProtKB/TrEMBL
Pfam Motilin_assoc UniProtKB/TrEMBL
  Motilin_ghrelin UniProtKB/TrEMBL
PRINTS GHRELIN UniProtKB/TrEMBL
UniProt A0A2R8ZRQ4_PANPA UniProtKB/TrEMBL
  A0A2R8ZRQ9_PANPA UniProtKB/TrEMBL
  A0A2R8ZSX1 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8ZSX5_PANPA UniProtKB/TrEMBL
  A0A2R8ZXJ1 ENTREZGENE, UniProtKB/TrEMBL