LEF1 (lymphoid enhancer binding factor 1) - Rat Genome Database

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Gene: LEF1 (lymphoid enhancer binding factor 1) Pan paniscus
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Symbol: LEF1
Name: lymphoid enhancer binding factor 1
RGD ID: 11788749
Description: ENCODES a protein that exhibits nucleic acid binding (ortholog); INVOLVED IN alpha-beta T cell differentiation (ortholog); anatomical structure regression (ortholog); animal organ regeneration (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH Animal Disease Models (ortholog); B-Cell Chronic Lymphocytic Leukemia (ortholog); basal cell carcinoma (ortholog); FOUND IN nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: lymphoid enhancer-binding factor 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23106,146,314 - 106,270,793 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14106,439,278 - 106,565,974 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04100,552,959 - 100,674,156 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14111,125,312 - 111,245,980 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4111,125,312 - 111,245,980 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
alpha-beta T cell differentiation  (IEA,ISO)
anatomical structure regression  (IEA,ISO)
animal organ regeneration  (ISO)
apoptotic process involved in blood vessel morphogenesis  (IEA,ISO)
apoptotic process involved in morphogenesis  (IEA,ISO)
B cell proliferation  (IEA,ISO)
BMP signaling pathway  (IEA,ISO)
branching involved in blood vessel morphogenesis  (IEA,ISO)
canonical Wnt signaling pathway  (IEA)
cell adhesion  (ISO)
cell chemotaxis  (IEA)
cell development  (IEA,ISO)
cellular response to cytokine stimulus  (IEA)
cellular response to interleukin-4  (IEA)
chorio-allantoic fusion  (IEA,ISO)
dentate gyrus development  (IEA,ISO)
embryonic limb morphogenesis  (IEA,ISO)
epithelial cell apoptotic process  (IEA,ISO)
epithelial to mesenchymal transition  (IEA)
face morphogenesis  (IEA,ISO)
forebrain neuroblast division  (IEA,ISO)
forebrain radial glial cell differentiation  (IEA,ISO)
formation of radial glial scaffolds  (IEA,ISO)
hippocampus development  (IEA,ISO)
kidney development  (ISO)
mammary gland development  (IEA,ISO)
negative regulation of apoptotic process  (IEA)
negative regulation of apoptotic process in bone marrow cell  (IEA)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of interleukin-13 production  (IEA)
negative regulation of interleukin-4 production  (IEA)
negative regulation of interleukin-5 production  (IEA)
negative regulation of striated muscle tissue development  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
neutrophil differentiation  (IEA)
odontoblast differentiation  (ISO)
odontogenesis of dentin-containing tooth  (IEA,ISO)
osteoblast differentiation  (IEA)
paraxial mesoderm formation  (IEA,ISO)
positive regulation by host of viral transcription  (IEA)
positive regulation of cell cycle process  (ISO)
positive regulation of cell migration  (IEA)
positive regulation of cell proliferation in bone marrow  (IEA)
positive regulation of chondrocyte proliferation  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of epithelial to mesenchymal transition  (IEA)
positive regulation of gamma-delta T cell differentiation  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of granulocyte differentiation  (IEA)
positive regulation of odontoblast differentiation  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of Wnt signaling pathway  (IEA,ISO)
protein localization to chromatin  (IEA)
regulation of cell-cell adhesion  (IEA,ISO)
regulation of DNA-templated transcription  (IEA)
regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of Wnt signaling pathway  (IEA,ISO)
secondary palate development  (IEA)
sensory perception of taste  (IEA,ISO)
skin development  (ISO)
somitogenesis  (IEA,ISO)
sprouting angiogenesis  (IEA,ISO)
T cell receptor V(D)J recombination  (IEA,ISO)
T-helper 1 cell differentiation  (IEA)
tongue development  (IEA,ISO)
trachea gland development  (IEA,ISO)
transcription by RNA polymerase II  (IEA,ISO)
vasculature development  (IEA,ISO)
Wnt signaling pathway  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
LEF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23106,146,314 - 106,270,793 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14106,439,278 - 106,565,974 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04100,552,959 - 100,674,156 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14111,125,312 - 111,245,980 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4111,125,312 - 111,245,980 (-)Ensemblpanpan1.1panPan2
LEF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384108,047,548 - 108,168,932 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4108,047,545 - 108,168,956 (-)EnsemblGRCh38hg38GRCh38
GRCh374108,968,704 - 109,090,088 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364109,188,150 - 109,309,027 (-)NCBINCBI36Build 36hg18NCBI36
Build 344109,326,304 - 109,447,182NCBI
Celera4106,263,513 - 106,384,975 (-)NCBICelera
Cytogenetic Map4q25NCBI
HuRef4104,700,344 - 104,821,596 (-)NCBIHuRef
CHM1_14108,945,152 - 109,066,566 (-)NCBICHM1_1
T2T-CHM13v2.04111,349,885 - 111,471,256 (-)NCBIT2T-CHM13v2.0
Lef1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393130,903,972 - 131,018,006 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3130,904,120 - 131,018,005 (+)EnsemblGRCm39 Ensembl
GRCm383131,110,297 - 131,224,357 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3131,110,471 - 131,224,356 (+)EnsemblGRCm38mm10GRCm38
MGSCv373130,813,389 - 130,926,252 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363131,099,626 - 131,212,489 (+)NCBIMGSCv36mm8
Celera3137,630,007 - 137,744,454 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map360.78NCBI
Lef1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82222,340,541 - 222,453,931 (+)NCBIGRCr8
mRatBN7.22219,666,549 - 219,779,815 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2219,666,592 - 219,779,794 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2227,324,033 - 227,418,775 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02225,223,708 - 225,318,451 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02220,081,321 - 220,176,071 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02236,232,115 - 236,345,061 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2236,233,239 - 236,345,056 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02254,781,171 - 254,893,756 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42228,550,263 - 228,673,131 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12228,537,002 - 228,659,871 (+)NCBI
Celera2211,924,784 - 212,018,812 (+)NCBICelera
Cytogenetic Map2q43NCBI
Lef1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554961,728,840 - 1,828,698 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554961,728,840 - 1,827,749 (+)NCBIChiLan1.0ChiLan1.0
LEF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13228,516,002 - 28,633,759 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3228,517,108 - 28,634,019 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3213,389,033 - 13,506,807 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03228,744,891 - 28,862,596 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3228,744,919 - 28,862,904 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13228,737,873 - 28,855,560 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03228,482,671 - 28,600,623 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03211,256,345 - 11,374,064 (+)NCBIUU_Cfam_GSD_1.0
Lef1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530112,484,346 - 12,597,999 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936818453,635 - 567,469 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936818453,635 - 569,194 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LEF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8113,825,161 - 113,944,070 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18113,824,511 - 113,944,078 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28122,085,854 - 122,204,415 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LEF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1755,974,770 - 56,096,214 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl755,990,621 - 56,094,110 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603734,601,310 - 34,723,183 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lef1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248301,321,387 - 1,424,389 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248301,320,034 - 1,422,774 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000063459   ⟹   ENSPPAP00000040542
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl4111,125,312 - 111,245,980 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000063462   ⟹   ENSPPAP00000040545
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl4111,125,312 - 111,245,980 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000063464   ⟹   ENSPPAP00000040547
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl4111,125,315 - 111,245,980 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000063468   ⟹   ENSPPAP00000040551
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl4111,141,171 - 111,243,385 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000063469   ⟹   ENSPPAP00000040552
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl4111,145,053 - 111,244,870 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000063472   ⟹   ENSPPAP00000040555
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl4111,158,854 - 111,243,385 (-)Ensembl
RefSeq Acc Id: XM_003829997   ⟹   XP_003830045
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v23106,147,382 - 106,266,616 (-)NCBI
NHGRI_mPanPan14106,439,278 - 106,561,113 (-)NCBI
Mhudiblu_PPA_v04100,552,959 - 100,674,156 (-)NCBI
PanPan1.14111,125,312 - 111,245,980 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003829998   ⟹   XP_003830046
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v23106,147,382 - 106,266,616 (-)NCBI
NHGRI_mPanPan14106,439,279 - 106,561,128 (-)NCBI
Mhudiblu_PPA_v04100,552,959 - 100,674,156 (-)NCBI
PanPan1.14111,125,312 - 111,245,980 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003829999   ⟹   XP_003830047
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v23106,146,314 - 106,270,793 (-)NCBI
NHGRI_mPanPan14106,439,280 - 106,565,974 (-)NCBI
Mhudiblu_PPA_v04100,552,959 - 100,674,156 (-)NCBI
PanPan1.14111,125,315 - 111,245,980 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008955362   ⟹   XP_008953610
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v23106,146,314 - 106,266,616 (-)NCBI
NHGRI_mPanPan14106,439,279 - 106,561,113 (-)NCBI
Mhudiblu_PPA_v04100,552,962 - 100,672,800 (-)NCBI
PanPan1.14111,125,315 - 111,245,064 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034958980   ⟹   XP_034814871
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v23106,146,314 - 106,264,897 (-)NCBI
NHGRI_mPanPan14106,439,279 - 106,560,136 (-)NCBI
Mhudiblu_PPA_v04100,552,962 - 100,671,860 (-)NCBI
RefSeq Acc Id: XM_034958981   ⟹   XP_034814872
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v23106,147,382 - 106,264,896 (-)NCBI
NHGRI_mPanPan14106,439,278 - 106,560,136 (-)NCBI
Mhudiblu_PPA_v04100,552,959 - 100,671,860 (-)NCBI
RefSeq Acc Id: XP_003830046   ⟸   XM_003829998
- Peptide Label: isoform X4
- UniProtKB: A0A2R9CF20 (UniProtKB/TrEMBL),   A0A2R9CPS3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003830045   ⟸   XM_003829997
- Peptide Label: isoform X2
- UniProtKB: A0A2R9CPR7 (UniProtKB/TrEMBL),   A0A2R9CPS3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003830047   ⟸   XM_003829999
- Peptide Label: isoform X3
- UniProtKB: A0A2R9CPR9 (UniProtKB/TrEMBL),   A0A2R9CPS3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008953610   ⟸   XM_008955362
- Peptide Label: isoform X1
- UniProtKB: A0A2R9CPS3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034814872   ⟸   XM_034958981
- Peptide Label: isoform X6
- UniProtKB: A0A2R9CF05 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034814871   ⟸   XM_034958980
- Peptide Label: isoform X5
Ensembl Acc Id: ENSPPAP00000040545   ⟸   ENSPPAT00000063462
Ensembl Acc Id: ENSPPAP00000040551   ⟸   ENSPPAT00000063468
Ensembl Acc Id: ENSPPAP00000040552   ⟸   ENSPPAT00000063469
Ensembl Acc Id: ENSPPAP00000040547   ⟸   ENSPPAT00000063464
Ensembl Acc Id: ENSPPAP00000040542   ⟸   ENSPPAT00000063459
Ensembl Acc Id: ENSPPAP00000040555   ⟸   ENSPPAT00000063472
Protein Domains
CTNNB1 binding N-teminal   HMG box


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000042910 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000063459.1 UniProtKB/TrEMBL
  ENSPPAT00000063462.1 UniProtKB/TrEMBL
  ENSPPAT00000063464.1 UniProtKB/TrEMBL
  ENSPPAT00000063468.1 UniProtKB/TrEMBL
  ENSPPAT00000063469.1 UniProtKB/TrEMBL
  ENSPPAT00000063472.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.30.10 UniProtKB/TrEMBL
  4.10.900.10 UniProtKB/TrEMBL
InterPro Catenin-bd_sf UniProtKB/TrEMBL
  CTNNB1-bd_N UniProtKB/TrEMBL
  HMG_box_dom UniProtKB/TrEMBL
  HMG_box_dom_sf UniProtKB/TrEMBL
  TCF/LEF UniProtKB/TrEMBL
KEGG Report pps:100995847 UniProtKB/TrEMBL
NCBI Gene LEF1 ENTREZGENE
PANTHER PTHR10373 UniProtKB/TrEMBL
  PTHR10373:SF11 UniProtKB/TrEMBL
Pfam CTNNB1_binding UniProtKB/TrEMBL
  HMG_box UniProtKB/TrEMBL
PROSITE HMG_BOX_2 UniProtKB/TrEMBL
SMART HMG UniProtKB/TrEMBL
Superfamily-SCOP SSF47095 UniProtKB/TrEMBL
UniProt A0A2R9CF05 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CF20 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CF31_PANPA UniProtKB/TrEMBL
  A0A2R9CPR7 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CPR9 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CPS3 ENTREZGENE, UniProtKB/TrEMBL