BRAF (B-Raf proto-oncogene, serine/threonine kinase) - Rat Genome Database

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Pathways
Gene: BRAF (B-Raf proto-oncogene, serine/threonine kinase) Pan paniscus
Analyze
Symbol: BRAF
Name: B-Raf proto-oncogene, serine/threonine kinase (Ensembl:B-Raf proto-onco, serine/threonine kinase)
RGD ID: 11781420
Description: ENCODES a protein that exhibits MAP kinase kinase kinase activity (ortholog); mitogen-activated protein kinase kinase binding (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN alpha-beta T cell differentiation (ortholog); CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (ortholog); CD4-positive, alpha-beta T cell differentiation (ortholog); PARTICIPATES IN adenosine signaling pathway; altered extracellular signal-regulated Raf/Mek/Erk signaling pathway; colorectal cancer pathway; ASSOCIATED WITH adrenocortical carcinoma (ortholog); ameloblastoma (ortholog); Aortic Aneurysm, Giant Congenital (ortholog); FOUND IN cell body (ortholog); cytoplasm (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serine/threonine-protein kinase B-raf; v-raf murine sarcoma viral oncogene homolog B1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26177,509,195 - 177,712,794 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1729,523,822 - 29,723,049 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07132,651,908 - 132,855,422 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17145,124,291 - 145,327,115 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7145,138,510 - 145,327,115 (-)EnsemblpanPan2panpan1.1
JBrowse:




Disease Annotations     Click to see Annotation Detail View
adrenocortical carcinoma  (ISO)
ameloblastoma  (ISO)
Aortic Aneurysm, Giant Congenital  (ISO)
arteriovenous malformations of the brain  (ISO)
ataxia telangiectasia  (ISO)
autosomal recessive Alport syndrome  (ISO)
bile duct adenoma  (ISO)
Breast Neoplasms  (ISO)
cancer  (ISO)
Carcinogenesis  (ISO)
cardiofaciocutaneous syndrome  (ISO)
cardiofaciocutaneous syndrome 1  (ISO)
cardiomyopathy  (ISO)
cholangiocarcinoma  (ISO)
colon carcinoma  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
Costello syndrome  (ISO)
craniopharyngioma  (ISO)
Dandy-Walker syndrome  (ISO)
Developmental Disabilities  (ISO)
diffuse large B-cell lymphoma  (ISO)
dilated cardiomyopathy  (ISO)
dysembryoplastic neuroepithelial tumor  (ISO)
dysplastic nevus syndrome  (ISO)
endometrial carcinoma  (ISO)
Experimental Melanoma  (ISO)
Experimental Neoplasms  (ISO)
familial melanoma  (ISO)
Follicular Thyroid Cancer  (ISO)
gallbladder cancer  (ISO)
ganglioglioma  (ISO)
gastric adenocarcinoma  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
germinoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic cardiomyopathy 4  (ISO)
intellectual disability  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
Kidney Neoplasms  (ISO)
Langerhans-cell histiocytosis  (ISO)
Liver Metastasis  (ISO)
Liver Neoplasms  (ISO)
long QT syndrome  (ISO)
long QT syndrome 1  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung carcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
lymphangioma  (ISO)
Lymphatic Metastasis  (ISO)
malignant astrocytoma  (ISO)
Mandibular Neoplasms  (ISO)
melanoma  (ISO)
Microsatellite Instability  (ISO)
multiple myeloma  (ISO)
myoepithelioma  (ISO)
Neoplasm Metastasis  (ISO)
nephroblastoma  (ISO)
neuroendocrine tumor  (ISO)
Nevus  (ISO)
newborn respiratory distress syndrome  (ISO)
non-Hodgkin lymphoma  (ISO)
Nonseminomatous Germ Cell Tumor  (ISO)
Noonan syndrome  (ISO)
Noonan syndrome 1  (ISO)
Noonan syndrome 7  (ISO)
Noonan syndrome with multiple lentigines  (ISO)
Noonan syndrome with multiple lentigines 3  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic acinar cell adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
papillary renal cell carcinoma  (ISO)
papillary thyroid carcinoma  (ISO)
PHACE Association  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
Premature Birth  (ISO)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
prostate adenocarcinoma  (ISO)
Prostate Cancer, Hereditary, 1  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary valve stenosis  (ISO)
RASopathy  (ISO)
Romano-Ward Syndrome  (ISO)
Sengers syndrome  (ISO)
Sezary's disease  (ISO)
skin melanoma  (ISO)
tethered spinal cord syndrome  (ISO)
Thyroid Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
Vascular Malformations  (ISO)
ventricular septal defect  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
alpha-beta T cell differentiation  (ISO)
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment  (ISO)
CD4-positive, alpha-beta T cell differentiation  (ISO)
cell differentiation  (ISO)
cellular response to calcium ion  (IEA)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to xenobiotic stimulus  (ISO)
endothelial cell apoptotic process  (ISO)
epidermal growth factor receptor signaling pathway  (IEA)
ERK1 and ERK2 cascade  (ISO)
establishment of protein localization to membrane  (IEA)
face development  (ISO)
head morphogenesis  (ISO)
long-term synaptic potentiation  (ISO)
MAPK cascade  (IEA)
myeloid progenitor cell differentiation  (ISO)
negative regulation of apoptotic process  (IEA)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of fibroblast migration  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of synaptic vesicle exocytosis  (ISO)
positive regulation of axon regeneration  (ISO)
positive regulation of axonogenesis  (ISO)
positive regulation of D-glucose transmembrane transport  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of substrate adhesion-dependent cell spreading  (ISO)
positive T cell selection  (ISO)
postsynaptic modulation of chemical synaptic transmission  (ISO)
protein phosphorylation  (ISO)
regulation of axon regeneration  (ISO)
regulation of cell population proliferation  (ISO)
regulation of T cell differentiation  (ISO)
response to cAMP  (ISO)
response to peptide hormone  (ISO)
signal transduction  (IEA)
somatic stem cell population maintenance  (ISO)
stress fiber assembly  (ISO)
substrate adhesion-dependent cell spreading  (ISO)
synaptic vesicle exocytosis  (ISO)
T cell differentiation in thymus  (ISO)
T cell receptor signaling pathway  (ISO)
thymus development  (ISO)
thyroid gland development  (ISO)
visual learning  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
BRAF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26177,509,195 - 177,712,794 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1729,523,822 - 29,723,049 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07132,651,908 - 132,855,422 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17145,124,291 - 145,327,115 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7145,138,510 - 145,327,115 (-)EnsemblpanPan2panpan1.1
BRAF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387140,713,328 - 140,924,929 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7140,719,327 - 140,924,929 (-)Ensemblhg38GRCh38
GRCh377140,413,128 - 140,624,729 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367140,080,751 - 140,271,033 (-)NCBIBuild 36Build 36hg18NCBI36
Build 347139,887,462 - 140,077,748NCBI
Celera7135,155,867 - 135,346,614 (-)NCBICelera
Cytogenetic Map7q34NCBI
HuRef7134,729,459 - 134,920,529 (-)NCBIHuRef
CHM1_17140,368,045 - 140,559,148 (-)NCBICHM1_1
T2T-CHM13v2.07142,027,505 - 142,239,131 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27139,771,989 - 139,962,886 (-)NCBI
Braf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39639,580,171 - 39,702,592 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl639,580,171 - 39,702,397 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38639,603,231 - 39,725,658 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl639,603,237 - 39,725,463 (-)Ensemblmm10GRCm38
MGSCv37639,553,236 - 39,675,462 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36639,557,807 - 39,675,462 (-)NCBIMGSCv36mm8
Celera639,588,093 - 39,710,723 (-)NCBICelera
Cytogenetic Map6B1NCBI
cM Map618.43NCBI
Braf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8469,329,772 - 69,476,931 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl469,342,813 - 69,476,931 (-)EnsemblGRCr8
mRatBN7.2468,375,484 - 68,510,652 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl468,384,649 - 68,510,463 (-)EnsemblmRatBN7.2
Rnor_6.0467,389,331 - 67,520,549 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl467,396,192 - 67,520,356 (-)Ensemblrn6Rnor6.0
Rnor_5.0467,196,477 - 67,327,649 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4467,117,759 - 67,243,058 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera463,383,337 - 63,515,499 (-)NCBICelera
RGSC_v3.1467,405,110 - 67,426,026 (-)NCBI
Cytogenetic Map4q23NCBI
Braf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554942,566,744 - 2,711,358 (+)Ensembl
ChiLan1.0NW_0049554942,567,238 - 2,712,708 (+)NCBIChiLan1.0ChiLan1.0
BRAF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1168,222,909 - 8,318,179 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl168,222,907 - 8,317,906 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha168,989,501 - 9,160,850 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0168,065,738 - 8,237,942 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl168,065,737 - 8,239,141 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1168,017,140 - 8,188,930 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0167,861,588 - 8,033,660 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0167,929,505 - 8,101,841 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Braf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511814,385,958 - 14,495,443 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365924,737,011 - 4,834,664 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365924,728,371 - 4,833,830 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BRAF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl188,957,991 - 9,132,553 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1188,957,963 - 9,132,558 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2189,522,257 - 9,636,501 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BRAF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121109,495,525 - 109,690,261 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660726,137,051 - 6,336,885 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Braf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476520,773,885 - 20,951,736 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476520,766,368 - 20,951,560 (-)NCBIHetGla 1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000048582   ⟹   ENSPPAP00000025752
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl7145,138,510 - 145,327,054 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000048585   ⟹   ENSPPAP00000025755
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl7145,138,510 - 145,256,303 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000048586   ⟹   ENSPPAP00000025756
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl7145,139,101 - 145,327,115 (-)Ensembl
RefSeq Acc Id: XM_008965952   ⟹   XP_008964200
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v26177,509,195 - 177,712,794 (-)NCBI
NHGRI_mPanPan1729,523,822 - 29,723,049 (-)NCBI
Mhudiblu_PPA_v07132,651,908 - 132,855,422 (-)NCBI
PanPan1.17145,124,291 - 145,327,115 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034965106   ⟹   XP_034820997
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v26177,509,195 - 177,712,786 (-)NCBI
NHGRI_mPanPan1729,523,822 - 29,723,034 (-)NCBI
Mhudiblu_PPA_v07132,651,908 - 132,855,422 (-)NCBI
RefSeq Acc Id: XM_034965107   ⟹   XP_034820998
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v26177,509,195 - 177,712,786 (-)NCBI
NHGRI_mPanPan1729,523,822 - 29,723,015 (-)NCBI
Mhudiblu_PPA_v07132,655,496 - 132,855,420 (-)NCBI
RefSeq Acc Id: XP_008964200   ⟸   XM_008965952
- Peptide Label: isoform X1
- UniProtKB: A0A2R9B9I1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034820997   ⟸   XM_034965106
- Peptide Label: isoform X2
- UniProtKB: A0A2R9B9I1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034820998   ⟸   XM_034965107
- Peptide Label: isoform X3
- UniProtKB: A0A2R9B9I1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000025752   ⟸   ENSPPAT00000048582
Ensembl Acc Id: ENSPPAP00000025755   ⟸   ENSPPAT00000048585
Ensembl Acc Id: ENSPPAP00000025756   ⟸   ENSPPAT00000048586
Protein Domains
Phorbol-ester/DAG-type   Protein kinase   RBD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000036004 Ensembl, UniProtKB/TrEMBL
  ENSPPAG00050021942 ENTREZGENE
Ensembl Transcript ENSPPAT00000048582.1 UniProtKB/TrEMBL
  ENSPPAT00000048585.1 UniProtKB/TrEMBL
  ENSPPAT00000048586.1 UniProtKB/TrEMBL
  ENSPPAT00050046289 ENTREZGENE
  ENSPPAT00050046316 ENTREZGENE
  ENSPPAT00050046361 ENTREZGENE
Gene3D-CATH 3.30.60.20 UniProtKB/TrEMBL
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro C1-like_sf UniProtKB/TrEMBL
  DAG/PE-bd UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  RBD_dom UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  Ser/Thr_Kinases-Pseudokinases UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
NCBI Gene BRAF ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED UniProtKB/TrEMBL
  SERINE_THREONINE-PROTEIN KINASE B-RAF UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  RBD UniProtKB/TrEMBL
PRINTS DAGPEDOMAIN UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  RBD UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
SMART RBD UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
Superfamily-SCOP SSF54236 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
  SSF57889 UniProtKB/TrEMBL
UniProt A0A2R9B9I1 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BBV0_PANPA UniProtKB/TrEMBL
  A0A2R9BFH5_PANPA UniProtKB/TrEMBL