CLCN2 (chloride voltage-gated channel 2) - Rat Genome Database

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Gene: CLCN2 (chloride voltage-gated channel 2) Pan paniscus
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Symbol: CLCN2
Name: chloride voltage-gated channel 2
RGD ID: 11751681
Description: ENCODES a protein that exhibits voltage-gated chloride channel activity (ortholog); volume-sensitive chloride channel activity (ortholog); INVOLVED IN acinar cell differentiation (ortholog); cell differentiation involved in salivary gland development (ortholog); cellular hypotonic response (ortholog); ASSOCIATED WITH 3-methylcrotonyl-CoA carboxylase 1 deficiency (ortholog); autistic disorder (ortholog); cerebellar ataxia (ortholog); FOUND IN axon initial segment (ortholog); dendrite (ortholog); perikaryon (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: chloride channel protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22182,219,532 - 182,235,030 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13182,223,590 - 182,239,652 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03181,383,608 - 181,399,200 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13189,865,627 - 189,881,049 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3189,862,489 - 189,881,049 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CLCN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22182,219,532 - 182,235,030 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13182,223,590 - 182,239,652 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03181,383,608 - 181,399,200 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13189,865,627 - 189,881,049 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3189,862,489 - 189,881,049 (-)Ensemblpanpan1.1panPan2
CLCN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383184,346,185 - 184,361,605 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3184,346,185 - 184,361,650 (-)EnsemblGRCh38hg38GRCh38
GRCh373184,063,973 - 184,079,393 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363185,547,034 - 185,562,085 (-)NCBINCBI36Build 36hg18NCBI36
Build 343185,547,095 - 185,561,969NCBI
Celera3182,504,875 - 182,520,290 (-)NCBICelera
Cytogenetic Map3q27.1NCBI
HuRef3181,470,404 - 181,485,871 (-)NCBIHuRef
CHM1_13184,028,432 - 184,043,898 (-)NCBICHM1_1
T2T-CHM13v2.03187,155,451 - 187,170,873 (-)NCBIT2T-CHM13v2.0
Clcn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391620,521,185 - 20,536,496 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1620,521,714 - 20,536,496 (-)EnsemblGRCm39 Ensembl
GRCm381620,702,435 - 20,717,746 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1620,702,964 - 20,717,746 (-)EnsemblGRCm38mm10GRCm38
MGSCv371620,703,039 - 20,716,709 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361620,616,509 - 20,629,657 (-)NCBIMGSCv36mm8
Celera1621,268,322 - 21,281,991 (-)NCBICelera
Cytogenetic Map16A3- B1NCBI
cM Map1612.5NCBI
Clcn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81193,702,382 - 93,716,059 (+)NCBIGRCr8
mRatBN7.21180,197,741 - 80,211,657 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,198,153 - 80,211,657 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1188,920,899 - 88,934,364 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01181,574,316 - 81,587,781 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01180,635,378 - 80,648,843 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01182,862,664 - 82,876,165 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1183,883,879 - 83,897,394 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01186,935,748 - 86,969,314 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,427,792 - 82,441,293 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11182,485,379 - 82,498,880 (+)NCBI
Celera1179,037,893 - 79,051,394 (+)NCBICelera
Cytogenetic Map11q23NCBI
Clcn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542023,138,605 - 23,152,311 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542023,138,558 - 23,152,462 (+)NCBIChiLan1.0ChiLan1.0
CLCN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13417,224,136 - 17,238,755 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3417,223,215 - 17,239,621 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3421,309,705 - 21,324,280 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03417,131,619 - 17,146,202 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3417,131,648 - 17,146,119 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13417,168,519 - 17,183,094 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03417,164,603 - 17,179,167 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03417,393,559 - 17,408,134 (-)NCBIUU_Cfam_GSD_1.0
Clcn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602119,433,596 - 119,447,715 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365785,525,601 - 5,539,472 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365785,525,461 - 5,539,351 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLCN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13122,234,736 - 122,249,867 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113122,234,731 - 122,249,889 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213131,674,508 - 131,689,583 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CLCN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1155,057,687 - 5,073,596 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl155,057,900 - 5,073,184 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606313,835,604 - 13,851,241 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Clcn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473072,228,189 - 72,244,332 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473072,228,912 - 72,242,636 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000041032   ⟹   ENSPPAP00000018303
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl3189,862,489 - 189,880,907 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000041047   ⟹   ENSPPAP00000018317
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl3189,865,633 - 189,881,049 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000041052   ⟹   ENSPPAP00000018322
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl3189,866,045 - 189,880,907 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000041058   ⟹   ENSPPAP00000018328
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl3189,866,045 - 189,878,262 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000041069   ⟹   ENSPPAP00000018339
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl3189,876,502 - 189,880,907 (-)Ensembl
RefSeq Acc Id: XM_003806572   ⟹   XP_003806620
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22182,219,532 - 182,235,030 (-)NCBI
NHGRI_mPanPan13182,223,590 - 182,239,652 (-)NCBI
Mhudiblu_PPA_v03181,383,608 - 181,399,200 (-)NCBI
PanPan1.13189,865,627 - 189,881,049 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003806573   ⟹   XP_003806621
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22182,219,532 - 182,235,030 (-)NCBI
NHGRI_mPanPan13182,223,590 - 182,239,652 (-)NCBI
Mhudiblu_PPA_v03181,383,636 - 181,399,047 (-)NCBI
PanPan1.13189,865,633 - 189,881,049 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034957821   ⟹   XP_034813712
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22182,219,532 - 182,235,030 (-)NCBI
NHGRI_mPanPan13182,223,590 - 182,239,583 (-)NCBI
Mhudiblu_PPA_v03181,383,636 - 181,398,968 (-)NCBI
RefSeq Acc Id: XM_034957822   ⟹   XP_034813713
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22182,219,532 - 182,235,030 (-)NCBI
NHGRI_mPanPan13182,223,590 - 182,239,652 (-)NCBI
Mhudiblu_PPA_v03181,383,636 - 181,399,047 (-)NCBI
RefSeq Acc Id: XM_055110757   ⟹   XP_054966732
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22182,220,348 - 182,235,030 (-)NCBI
NHGRI_mPanPan13182,225,065 - 182,239,652 (-)NCBI
RefSeq Acc Id: XM_063603009   ⟹   XP_063459079
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22182,219,532 - 182,235,030 (-)NCBI
RefSeq Acc Id: XM_063603010   ⟹   XP_063459080
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22182,219,532 - 182,235,030 (-)NCBI
RefSeq Acc Id: XP_003806620   ⟸   XM_003806572
- Peptide Label: isoform X1
- UniProtKB: A0A2R9AMC9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003806621   ⟸   XM_003806573
- Peptide Label: isoform X3
- UniProtKB: A0A2R9ALT8 (UniProtKB/TrEMBL),   A0A2R9AMC9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034813713   ⟸   XM_034957822
- Peptide Label: isoform X4
- UniProtKB: A0A2R9ALU3 (UniProtKB/TrEMBL),   A0A2R9AMC9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034813712   ⟸   XM_034957821
- Peptide Label: isoform X2
- UniProtKB: A0A2R9AMF4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000018303   ⟸   ENSPPAT00000041032
Ensembl Acc Id: ENSPPAP00000018317   ⟸   ENSPPAT00000041047
Ensembl Acc Id: ENSPPAP00000018328   ⟸   ENSPPAT00000041058
Ensembl Acc Id: ENSPPAP00000018322   ⟸   ENSPPAT00000041052
Ensembl Acc Id: ENSPPAP00000018339   ⟸   ENSPPAT00000041069
RefSeq Acc Id: XP_054966732   ⟸   XM_055110757
- Peptide Label: isoform X5
- UniProtKB: A0A2R9AMC9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063459080   ⟸   XM_063603010
- Peptide Label: isoform X7
- UniProtKB: A0A2R9AMC9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063459079   ⟸   XM_063603009
- Peptide Label: isoform X6
- UniProtKB: A0A2R9AMC9 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000032193 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000041032.1 UniProtKB/TrEMBL
  ENSPPAT00000041047.1 UniProtKB/TrEMBL
  ENSPPAT00000041052.1 UniProtKB/TrEMBL
  ENSPPAT00000041058.1 UniProtKB/TrEMBL
  ENSPPAT00000041069.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.580.10 UniProtKB/TrEMBL
  Clc chloride channel UniProtKB/TrEMBL
InterPro CBS_dom_sf UniProtKB/TrEMBL
  Cl-channel-2 UniProtKB/TrEMBL
  Cl-channel_core UniProtKB/TrEMBL
  Cl-channel_volt-gated UniProtKB/TrEMBL
  Cl_channel_volt-gated UniProtKB/TrEMBL
NCBI Gene CLCN2 ENTREZGENE
PANTHER CHLORIDE CHANNEL PROTEIN 2 UniProtKB/TrEMBL
  CHLORIDE CHANNEL PROTEIN 2 UniProtKB/TrEMBL
Pfam Voltage_CLC UniProtKB/TrEMBL
PRINTS CLCHANNEL UniProtKB/TrEMBL
  CLCHANNEL2 UniProtKB/TrEMBL
Superfamily-SCOP SSF54631 UniProtKB/TrEMBL
  SSF81340 UniProtKB/TrEMBL
UniProt A0A2R9ALT8 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9ALU3 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AMC9 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AMF4 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9ATV6_PANPA UniProtKB/TrEMBL