HSPD1 (heat shock protein family D (Hsp60) member 1) - Rat Genome Database

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Gene: HSPD1 (heat shock protein family D (Hsp60) member 1) Pan paniscus
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Symbol: HSPD1
Name: heat shock protein family D (Hsp60) member 1
RGD ID: 11727873
Description: ENCODES a protein that exhibits cysteine-type endopeptidase activator activity (ortholog); modification-dependent protein binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN adhesion of symbiont to host (ortholog); apoptotic mitochondrial changes (ortholog); cellular response to heat (ortholog); ASSOCIATED WITH Acute Coronary Syndrome (ortholog); adenocarcinoma (ortholog); Alzheimer's disease (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog); Golgi cisterna (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 60 kDa heat shock protein, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213100,100,280 - 100,114,129 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B100,115,490 - 100,129,121 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B84,729,615 - 84,743,352 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B202,623,497 - 202,637,045 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B202,623,497 - 202,636,959 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adhesion of symbiont to host  (ISO)
apoptotic mitochondrial changes  (ISO)
B cell activation  (IEA)
B cell proliferation  (IEA)
biological process involved in interaction with symbiont  (IEA)
cellular response to heat  (ISO)
cellular response to interleukin-7  (ISO)
isotype switching to IgG isotypes  (IEA)
MyD88-dependent toll-like receptor signaling pathway  (IEA)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of apoptotic process in bone marrow cell  (ISO)
negative regulation of execution phase of apoptosis  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of apoptotic process  (IEA)
positive regulation of execution phase of apoptosis  (ISO)
positive regulation of interferon-alpha production  (IEA,ISO)
positive regulation of interleukin-10 production  (IEA)
positive regulation of interleukin-12 production  (IEA)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of macrophage activation  (IEA)
positive regulation of T cell activation  (IEA)
positive regulation of T cell mediated immune response to tumor cell  (IEA)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type II interferon production  (IEA,ISO)
protein refolding  (IEA)
protein stabilization  (IEA)
response to activity  (ISO)
response to ATP  (ISO)
response to cocaine  (ISO)
response to estrogen  (ISO)
response to glucocorticoid  (ISO)
response to hydrogen peroxide  (ISO)
response to hypoxia  (ISO)
response to ischemia  (ISO)
response to lipopolysaccharide  (ISO)
response to resveratrol  (ISO)
response to unfolded protein  (IEA)
response to xenobiotic stimulus  (ISO)
T cell activation  (IEA,ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HSPD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213100,100,280 - 100,114,129 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B100,115,490 - 100,129,121 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B84,729,615 - 84,743,352 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B202,623,497 - 202,637,045 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B202,623,497 - 202,636,959 (-)Ensemblpanpan1.1panPan2
HSPD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382197,486,584 - 197,500,274 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2197,486,584 - 197,516,737 (-)EnsemblGRCh38hg38GRCh38
GRCh372198,351,308 - 198,364,998 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362198,059,553 - 198,073,243 (-)NCBINCBI36Build 36hg18NCBI36
Build 342198,176,815 - 198,190,504NCBI
Celera2192,107,181 - 192,120,871 (-)NCBICelera
Cytogenetic Map2q33.1NCBI
HuRef2190,203,711 - 190,217,402 (-)NCBIHuRef
CHM1_12198,357,144 - 198,370,838 (-)NCBICHM1_1
T2T-CHM13v2.02197,970,209 - 197,983,875 (-)NCBIT2T-CHM13v2.0
Hspd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39155,116,992 - 55,127,402 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl155,116,994 - 55,127,402 (-)EnsemblGRCm39 Ensembl
GRCm38155,077,833 - 55,088,243 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl155,077,835 - 55,088,243 (-)EnsemblGRCm38mm10GRCm38
MGSCv37155,134,678 - 55,144,776 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36155,022,380 - 55,032,390 (-)NCBIMGSCv36mm8
Celera155,597,904 - 55,608,002 (-)NCBICelera
Cytogenetic Map1C1.2NCBI
cM Map128.01NCBI
Hspd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8964,073,610 - 64,084,332 (-)NCBIGRCr8
mRatBN7.2956,579,195 - 56,590,011 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl956,579,201 - 56,589,662 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx965,088,118 - 65,098,576 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0970,204,015 - 70,214,473 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0968,503,767 - 68,514,191 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0961,680,529 - 61,691,202 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl961,680,530 - 61,690,956 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0961,361,745 - 61,372,414 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4953,884,193 - 53,895,043 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1953,885,606 - 53,895,580 (-)NCBI
Celera954,060,669 - 54,071,096 (-)NCBICelera
Cytogenetic Map9q31NCBI
Hspd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554033,063,133 - 3,073,419 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554033,062,724 - 3,073,419 (+)NCBIChiLan1.0ChiLan1.0
HSPD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1377,010,421 - 7,025,912 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha377,956,566 - 7,967,852 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0376,900,931 - 6,911,990 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl376,900,933 - 6,911,980 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1376,899,765 - 6,910,835 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0376,866,679 - 6,877,757 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0376,889,830 - 6,900,900 (-)NCBIUU_Cfam_GSD_1.0
Hspd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303155,150,440 - 155,160,005 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365061,678,069 - 1,687,632 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15101,360,094 - 101,373,526 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115101,360,355 - 101,373,498 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215112,534,459 - 112,547,603 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HSPD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11083,003,266 - 83,017,397 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1083,003,717 - 83,017,363 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040116,426,692 - 116,441,017 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hspd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248892,736,727 - 2,746,333 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000054815   ⟹   ENSPPAP00000031949
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B202,623,497 - 202,636,959 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000054844   ⟹   ENSPPAP00000031978
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B202,623,959 - 202,635,764 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000054847   ⟹   ENSPPAP00000031981
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B202,624,029 - 202,635,764 (-)Ensembl
RefSeq Acc Id: XM_003825305   ⟹   XP_003825353
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v213100,100,280 - 100,113,643 (-)NCBI
NHGRI_mPanPan12B100,115,490 - 100,128,762 (-)NCBI
Mhudiblu_PPA_v02B84,729,615 - 84,742,993 (-)NCBI
PanPan1.12B202,623,497 - 202,636,959 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008950645   ⟹   XP_008948893
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v213100,100,280 - 100,113,865 (-)NCBI
NHGRI_mPanPan12B100,115,490 - 100,128,905 (-)NCBI
Mhudiblu_PPA_v02B84,729,615 - 84,743,183 (-)NCBI
PanPan1.12B202,623,497 - 202,637,045 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034954738   ⟹   XP_034810629
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v213100,100,280 - 100,114,129 (-)NCBI
NHGRI_mPanPan12B100,115,490 - 100,129,121 (-)NCBI
Mhudiblu_PPA_v02B84,729,615 - 84,743,352 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003825353 (Get FASTA)   NCBI Sequence Viewer  
  XP_008948893 (Get FASTA)   NCBI Sequence Viewer  
  XP_034810629 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000031949
  ENSPPAP00000031949.1
  ENSPPAP00000031978
  ENSPPAP00000031978.1
  ENSPPAP00000031981.1
RefSeq Acc Id: XP_008948893   ⟸   XM_008950645
- UniProtKB: A0A2R9BU33 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003825353   ⟸   XM_003825305
- UniProtKB: A0A2R9BU33 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034810629   ⟸   XM_034954738
- UniProtKB: A0A2R9BU33 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000031978   ⟸   ENSPPAT00000054844
Ensembl Acc Id: ENSPPAP00000031981   ⟸   ENSPPAT00000054847
Ensembl Acc Id: ENSPPAP00000031949   ⟸   ENSPPAT00000054815


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000038858 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000054815.1 UniProtKB/TrEMBL
  ENSPPAT00000054844.1 UniProtKB/TrEMBL
  ENSPPAT00000054847.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.560.10 UniProtKB/TrEMBL
  3.30.260.10 UniProtKB/TrEMBL
  3.50.7.10 UniProtKB/TrEMBL
InterPro Chaperone_TCP-1 UniProtKB/TrEMBL
  Chaperonin_Cpn60_CS UniProtKB/TrEMBL
  Chaprnin_Cpn60 UniProtKB/TrEMBL
  Cpn60/TCP-1 UniProtKB/TrEMBL
  GroEL-like_apical_dom_sf UniProtKB/TrEMBL
  GROEL-like_equatorial_sf UniProtKB/TrEMBL
  TCP-1-like_intermed_sf UniProtKB/TrEMBL
NCBI Gene HSPD1 ENTREZGENE
PANTHER 60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL UniProtKB/TrEMBL
  60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam Cpn60_TCP1 UniProtKB/TrEMBL
PRINTS CHAPERONIN60 UniProtKB/TrEMBL
  TCOMPLEXTCP1 UniProtKB/TrEMBL
PROSITE CHAPERONINS_CPN60 UniProtKB/TrEMBL
Superfamily-SCOP SSF48592 UniProtKB/TrEMBL
  SSF52029 UniProtKB/TrEMBL
  SSF54849 UniProtKB/TrEMBL
UniProt A0A2R9BQN5_PANPA UniProtKB/TrEMBL
  A0A2R9BU33 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BZQ7_PANPA UniProtKB/TrEMBL