SPPL3 (signal peptide peptidase like 3) - Rat Genome Database

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Gene: SPPL3 (signal peptide peptidase like 3) Pan paniscus
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Symbol: SPPL3
Name: signal peptide peptidase like 3
RGD ID: 11680974
Description: ENCODES a protein that exhibits aspartic endopeptidase activity, intramembrane cleaving (inferred); peptidase activity (inferred); protein homodimerization activity (inferred); INVOLVED IN membrane protein ectodomain proteolysis (ortholog); ASSOCIATED WITH short chain acyl-CoA dehydrogenase deficiency (ortholog); FOUND IN cytoplasmic side of endoplasmic reticulum membrane (inferred); endomembrane system (inferred); endoplasmic reticulum-Golgi intermediate compartment membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: signal peptide peptidase-like 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210128,837,951 - 128,976,306 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112128,834,324 - 128,972,679 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012118,351,199 - 118,489,579 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112121,723,881 - 121,858,502 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12121,723,881 - 121,773,429 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SPPL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210128,837,951 - 128,976,306 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112128,834,324 - 128,972,679 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012118,351,199 - 118,489,579 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112121,723,881 - 121,858,502 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12121,723,881 - 121,773,429 (-)Ensemblpanpan1.1panPan2
SPPL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812120,762,510 - 120,904,358 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12120,762,510 - 120,904,358 (-)EnsemblGRCh38hg38GRCh38
GRCh3712121,200,313 - 121,342,161 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612119,685,418 - 119,826,534 (-)NCBINCBI36Build 36hg18NCBI36
Celera12120,835,168 - 120,976,050 (-)NCBICelera
Cytogenetic Map12q24.31NCBI
HuRef12118,209,451 - 118,351,576 (-)NCBIHuRef
CHM1_112121,169,084 - 121,310,844 (-)NCBICHM1_1
T2T-CHM13v2.012120,751,646 - 120,893,446 (-)NCBIT2T-CHM13v2.0
Sppl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395115,149,204 - 115,236,849 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5115,149,196 - 115,236,849 (+)EnsemblGRCm39 Ensembl
GRCm385115,011,524 - 115,098,790 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5115,011,137 - 115,098,790 (+)EnsemblGRCm38mm10GRCm38
MGSCv375115,461,533 - 115,548,799 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365115,272,523 - 115,359,789 (+)NCBIMGSCv36mm8
Celera5112,107,828 - 112,194,819 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.99NCBI
Sppl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81247,176,317 - 47,260,756 (-)NCBIGRCr8
mRatBN7.21241,515,635 - 41,600,079 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1241,515,640 - 41,600,126 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01247,276,485 - 47,360,552 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,276,476 - 47,360,507 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01249,071,961 - 49,156,613 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41242,788,576 - 42,882,650 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1243,134,305 - 43,170,708 (-)NCBICelera
Cytogenetic Map12q16NCBI
Sppl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545510,760,804 - 10,907,024 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545510,849,627 - 10,905,515 (+)NCBIChiLan1.0ChiLan1.0
SPPL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12616,620,236 - 16,760,616 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2616,621,455 - 16,760,623 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2616,622,725 - 16,762,963 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02616,886,222 - 17,026,542 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2616,887,266 - 17,026,468 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12616,847,005 - 16,987,200 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02616,922,683 - 17,062,392 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02616,965,017 - 17,105,003 (-)NCBIUU_Cfam_GSD_1.0
Sppl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118145,694,867 - 145,731,325 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936668193,723 - 231,088 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936668193,753 - 229,859 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPPL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1440,699,937 - 40,822,761 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11440,699,931 - 40,870,288 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21443,167,682 - 43,217,584 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPPL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111116,125,042 - 116,267,226 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11116,124,221 - 116,267,108 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037128,831,057 - 128,972,698 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sppl3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474712,795,563 - 12,928,649 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474712,795,803 - 12,925,319 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000038353   ⟹   ENSPPAP00000015662
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl12121,723,881 - 121,771,303 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000038360   ⟹   ENSPPAP00000015669
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl12121,725,656 - 121,773,429 (-)Ensembl
RefSeq Acc Id: XM_034934655   ⟹   XP_034790546
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v210128,837,951 - 128,976,306 (-)NCBI
NHGRI_mPanPan112128,834,324 - 128,972,679 (-)NCBI
Mhudiblu_PPA_v012118,351,199 - 118,489,579 (-)NCBI
RefSeq Acc Id: XM_034934656   ⟹   XP_034790547
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v210128,837,951 - 128,976,176 (-)NCBI
NHGRI_mPanPan112128,834,324 - 128,972,406 (-)NCBI
Mhudiblu_PPA_v012118,351,204 - 118,489,296 (-)NCBI
RefSeq Acc Id: XM_055096258   ⟹   XP_054952233
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v210128,837,951 - 128,976,176 (-)NCBI
NHGRI_mPanPan112128,834,324 - 128,972,434 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034790546 (Get FASTA)   NCBI Sequence Viewer  
  XP_034790547 (Get FASTA)   NCBI Sequence Viewer  
  XP_054952233 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000015662.1
  ENSPPAP00000015669.1
RefSeq Acc Id: XP_034790546   ⟸   XM_034934655
- Peptide Label: isoform X1
- UniProtKB: A0A2R9AJ75 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034790547   ⟸   XM_034934656
- Peptide Label: isoform X3
- UniProtKB: A0A2R9AFB9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000015662   ⟸   ENSPPAT00000038353
Ensembl Acc Id: ENSPPAP00000015669   ⟸   ENSPPAT00000038360
RefSeq Acc Id: XP_054952233   ⟸   XM_055096258
- Peptide Label: isoform X2
- UniProtKB: A0A2R9AJ75 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000030929 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000038353.1 UniProtKB/TrEMBL
  ENSPPAT00000038360.1 UniProtKB/TrEMBL
InterPro Peptidase_A22B_SPP UniProtKB/TrEMBL
  Preselin/SPP UniProtKB/TrEMBL
NCBI Gene SPPL3 ENTREZGENE
PANTHER PTHR12174 UniProtKB/TrEMBL
  SIGNAL PEPTIDE PEPTIDASE-LIKE 3 UniProtKB/TrEMBL
Pfam Peptidase_A22B UniProtKB/TrEMBL
SMART PSN UniProtKB/TrEMBL
UniProt A0A2R9AFB9 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AJ75 ENTREZGENE, UniProtKB/TrEMBL