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Gene: DHFR (dihydrofolate reductase) Pan paniscus

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Symbol:

DHFR

Name:

dihydrofolate reductase

RGD ID:

11680488

Description:

ENCODES a protein that exhibits dihydrofolate reductase activity (ortholog); dihydrofolic acid binding (ortholog); NADP binding (ortholog); INVOLVED IN axon regeneration (ortholog); dihydrofolate metabolic process (ortholog); positive regulation of nitric-oxide synthase activity (ortholog); PARTICIPATES IN altered folate cycle metabolic pathway; dopa responsive dystonia pathway; folate cycle metabolic pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); autistic disorder (ortholog); Breast Neoplasms (ortholog); FOUND IN nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DHFR (dihydrofolate reductase)	NCBI	Ortholog
Mus musculus (house mouse):	Dhfr (dihydrofolate reductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Dhfr (dihydrofolate reductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dhfr (dihydrofolate reductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DHFR (dihydrofolate reductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dhfr (dihydrofolate reductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DHFR (dihydrofolate reductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DHFR (dihydrofolate reductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dhfr (dihydrofolate reductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	34,653,369 - 34,681,917 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	32,806,994 - 32,835,542 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	34,663,210 - 34,689,467 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	34,938,548 - 34,967,003 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	34,938,548 - 34,967,003 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute lymphoblastic leukemia (ISO)

autistic disorder (ISO)

Breast Neoplasms (ISO)

Chemical and Drug Induced Liver Injury (ISO)

Colorectal Neoplasms (ISO)

endometrial cancer (ISO)

endometrial carcinoma (ISO)

familial adenomatous polyposis 4 (ISO)

Female Infertility (ISO)

folic acid deficiency anemia (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

Hereditary Neoplastic Syndromes (ISO)

inherited metabolic disorder (ISO)

Kidney Reperfusion Injury (ISO)

lung cancer (ISO)

megaloblastic anemia (ISO)

Megaloblastic Anemia due to Dihydrofolate Reductase Deficiency (ISO)

myeloid leukemia (ISO)

Neoplasm Metastasis (ISO)

nervous system disease (ISO)

Neurodevelopmental Disorders (ISO)

osteosarcoma (ISO)

pancytopenia (ISO)

rheumatoid arthritis (ISO)

Spontaneous Abortions (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

axon regeneration (ISO)

dihydrofolate metabolic process (IEA,ISO)

folic acid metabolic process (IEA)

negative regulation of translation (IEA)

one-carbon metabolic process (IEA)

positive regulation of nitric-oxide synthase activity (ISO)

regulation of removal of superoxide radicals (IEA)

response to methotrexate (IEA)

response to nicotine (ISO)

tetrahydrobiopterin biosynthetic process (IEA)

tetrahydrofolate biosynthetic process (IEA,ISO)

tetrahydrofolate interconversion (IEA)

tetrahydrofolate metabolic process (IEA)

Cellular Component

cytoplasm (IEA)

mitochondrion (IEA)

nucleus (IEA,ISO)

Molecular Function

dihydrofolate reductase activity (IEA,ISO)

dihydrofolic acid binding (ISO)

folic acid binding (IEA)

mRNA binding (IEA)

mRNA regulatory element binding translation repressor activity (IEA)

NADP binding (IEA,ISO)

NADPH binding (IEA)

oxidoreductase activity (IEA)

protein binding (ISO)

sequence-specific mRNA binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

altered folate cycle metabolic pathway (ISO)

dopa responsive dystonia pathway (ISO)

folate cycle metabolic pathway (ISO)

folate mediated one-carbon metabolic pathway (ISO)

folate metabolic pathway (ISO)

hereditary folate malabsorption pathway (ISO)

methotrexate pharmacodynamics pathway (ISO)

pyrimidine metabolic pathway (ISO)

Segawa syndrome pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

DHFR
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	34,653,369 - 34,681,917 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	32,806,994 - 32,835,542 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	34,663,210 - 34,689,467 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	34,938,548 - 34,967,003 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	34,938,548 - 34,967,003 (+)	Ensembl	panpan1.1		panPan2

DHFR
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	80,626,226 - 80,654,983 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	80,626,226 - 80,654,983 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	79,922,045 - 79,950,802 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	79,957,801 - 79,986,556 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	79,957,803 - 79,986,572	NCBI
Celera	5	75,825,049 - 75,854,857 (-)	NCBI		Celera
Cytogenetic Map	5	q14.1	NCBI
HuRef	5	75,130,997 - 75,159,721 (-)	NCBI		HuRef
CHM1_1	5	79,355,281 - 79,384,046 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	81,111,116 - 81,139,892 (-)	NCBI		T2T-CHM13v2.0

Dhfr
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	92,491,291 - 92,525,561 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	92,491,234 - 92,525,561 (+)	Ensembl		GRCm39 Ensembl
GRCm38	13	92,354,783 - 92,389,053 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	92,354,726 - 92,389,053 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	93,124,738 - 93,159,008 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	93,455,536 - 93,489,806 (+)	NCBI		MGSCv36	mm8
Celera	13	95,961,012 - 95,994,907 (+)	NCBI		Celera
Cytogenetic Map	13	C3	NCBI
cM Map	13	47.64	NCBI

Dhfr
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	25,320,895 - 25,346,004 (+)	NCBI		GRCr8
mRatBN7.2	2	23,585,876 - 23,611,199 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	23,586,031 - 23,613,713 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	30,620,446 - 30,644,695 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	28,720,807 - 28,745,052 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	23,548,630 - 23,573,162 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	21,931,887 - 21,958,927 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	21,931,493 - 21,962,453 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	41,137,784 - 41,149,417 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	2	41,162,308 - 41,162,496 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	22,607,093 - 22,828,487 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	22,527,461 - 22,748,856 (+)	NCBI
Celera	2	19,675,965 - 19,700,103 (+)	NCBI		Celera
Cytogenetic Map	2	q12	NCBI

Dhfr
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955418	29,274,170 - 29,283,028 (+)	NCBI	ChiLan1.0	ChiLan1.0

DHFR
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	26,521,214 - 26,556,065 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	27,762,458 - 27,797,614 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	26,441,764 - 26,476,948 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	26,441,755 - 26,468,894 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	26,381,985 - 26,417,256 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	26,356,657 - 26,413,875 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	26,636,300 - 26,671,702 (+)	NCBI		UU_Cfam_GSD_1.0

Dhfr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	182,542,580 - 182,561,929 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936469	67,962 - 83,116 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DHFR
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	2	89,230,660 - 89,255,830 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	91,077,865 - 91,102,076 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DHFR
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	74,787,292 - 74,811,196 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	74,787,629 - 74,810,960 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666049	23,650,277 - 23,674,290 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dhfr
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624743	1,446,643 - 1,461,863 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624743	1,446,643 - 1,462,319 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003822267	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008975788	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000030838 ⟹ ENSPPAP00000008203

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	5	34,938,548 - 34,967,003 (+)	Ensembl

Ensembl Acc Id:

ENSPPAT00000030841 ⟹ ENSPPAP00000008206

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	5	34,938,699 - 34,964,090 (+)	Ensembl

RefSeq Acc Id:

XM_003822267 ⟹ XP_003822315

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	4	34,653,369 - 34,681,917 (+)	NCBI
NHGRI_mPanPan1	5	32,806,994 - 32,835,542 (+)	NCBI
Mhudiblu_PPA_v0	5	34,663,210 - 34,689,467 (+)	NCBI
PanPan1.1	5	34,938,548 - 34,967,003 (+)	NCBI

Sequence:

show sequence

GCAACGCCGCGACCCTGCGTGCGCCGGGGCGGGGGGCGGGGCCTCGCCTGCACAAATAGGGACG
AGGGGGCGGGGCGGCCACAATTTCGCGCCAAACTTGACCGCGCGTTCTGCTGTAACGAGCGGGC
TCGGAGGTCCTCCCGCTGCTGTCATGGTTGGTTCGCTAAACTGCATCGTCGCTGTGTCCCAGAA
CATGGGCATCGGCAAGAACGGGGACCTGCCCTGGCCACCGCTCAGGAATGAATTCAGATATTTC
CAGAGAATGACCACAACCTCTTCAGTAGAAGGTAAACAGAATCTGGTGATTATGGGTAAGAAGA
CCTGGTTCTCCATTCCTGAGAAGAATCGACCTTTAAAGGGTAGAATTAATTTAGTTCTCAGCAG
AGAACTCAAGGAACCTCCACAAGGAGCTCATTTTCTTTCCAGAAGTCTAGATGATGCCTTAAAA
CTTACTGAACAACCAGAATTAGCAAGTAAAGTAGACATGGTCTGGATAGTTGGTGGCAGTTCTG
TTTATAAGGAAGCCATGAATCACCCAGGCCATCTTAAACTATTTGTGACAAGGATCATGCAAGA
CTTTGAAAGTGACACGTTTTTTCCAGAAATTGATTTGGAGAAATATAAACTTCTGCCAGAATAC
CCAGGTGTTCTCTCTGATGTCCAGGAGGAGAAAGGCATTAAGTACAAATTTGAAGTATATGAGA
AGAATGATTAATATGAAGGTGTTTTCTGGTTTAAGTTGTTCCCCCTCCCTCTGAAAAAAGTATG
TATTTTTACATTAGAAAAGGTCTTTTGTTGACTTTAGATCTATAATTATTTCTAAGCAACTTGT
TTTTATTCCCCACTACTCTTGTCTCTATCAGATACCATTTATGAGACATTCTTGCTATAACTAA
GTGCTTCTCCAAGACCCCAACTGAGTCCCCAGCACCTGCTACAGTGAGCTGCCATTCCACACCC
ATCACATGTGGCACTCCTGCCAGTCCTTGACATTGTCGGGCTTTTCACATGTTGGTAACATTTA
TTAAAGATGAAGATCCACATACCCTTCAACTGAGCAGTTTCACTAGTGGAAATACCAAAAGCTT
CCTACGTGTATATCCAGAGGTTTGTAGATAAATGTTGCCGCCTTGTTTGTAACAGTGAAAAATT
GAAAACAACCTGGAAGTCCAGTGATGGGAAAATGAGTATGTTTCTGTCTTAGATTGGGGAACCC
AAAGCAGATTCCAAGACTGAAATTTCAGTGAAAGCAGTTTATTTGCTAGGTCATACCAGAAATC
ATCAATTGAGGTATGGAGAAACTGAACTGAGAAGGTAAGAAAAGCAATTTAAAGTCAGCGAGCA
GGTTCTTATCGGTAACAAGCTCCCTACTGCTGAGATACAGGGAAATGGAGGGGAGAAAGCTGGA
GTATTGATCCCGTCCCCCTCCTTGGTTGTCAGCTCCCTGTCCTGTGTGTGGGCGGAACATACTC
TAGCTGCTCTATAGCAAGTCCCAGGTGTTTGCAGTAAGAAGCTGCTGGCATGCACGGGAACAGT
GAATGCCAAACACTTAAAGCAATTCGATGTTTAAGTATGTAAGTTCTTTTTTTTTAGACAGCGT
TTCGCTCTTGTTGCCCAGGCTAGCATGCAATGGTGTGACCTCGGCTTACTGCAACCTCCGCCTT
CCCAGATTCAAGCGATTCTCCTGCCTCAGGCTCCCAAGTAGCTAGGACCAGGCGTGTGCCACCA
CGCCCGGCTAATTTTTGTACTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGTTAGGC
TAGTCTCAAACTCGTGACCGCAAGCGATTCACCCACCTCAGCCTCCCAAAGTGCTGGGATTACC
GGCTTGAGCCACCACACCCGGCACATCTTCATTCTTTTTATGTAGTAAAAAGTATAAGGTCACA
CATGGTTTATTTGAAGTATTTTATAATTTAAAAAAATACAGAAGCAGGAAAACCAATTCTAAGT
TCAAGTGAGGGATGATGGTTGCTTGAACCAAAGGGTTGCATGTAGTAAGAAATTGTGATTTAAG
ATATATTTTAAAGTTATAAGTAGCAGGATATTCTGATGGAGTTTGACTTTGGTTTTGGGCCCAA
GGAGTTTCAGATGCCTTTGAGAAATGAATGAAGTAGAGAGAAAATAAAAGAAAAACTAGCCAGG
CACAGTGGCTCACACCTGTAATCCCAGTGCTTTGGGAGGCTAAGGCAGGCAGATCACTTGAGAC
CAGCTTGGGCAACATGGCAAAGCCCCATCTCTACAAAAAACACAAAAATTAGCTGGGCATTGTG
GCGCACACCTGTATTCCCATCTACTCAGGAAGCTGAGATGGAAGAATTAATTGAGCCCACGAGT
TCAAGGCTGCAGTGAGTCGTGATTGTGCCACTGCACTCCAGCCGGGGTGACAGAAGAGACCTTG
TCTCGAAAAGGAATCTGAAAACAATGGAACCATGCCTTCATAATTCTAGAAAGTTATTTTCAAC
TGATAAATCTATATTCACCCAAATAATCAAGGGTGAAGGTAAAATAATACATTTTTAGACAAGC
AAAGACTCAGGGGTTGCCTCCATGTACCCGTTTTAGGGAAGCTGTTGGAGAAAATACTCCAGCA
AGATGAAGGCGTACACAAACCAGAGAATGGCATGGATCCAGCAAATAGCATCCAACACAGGCAA
TGTTCCAGCTATGGAGCTGGCTTTAAAAAGGAACAGTAAAAATATTAATCGGTTAGCTGGGTGG
AATGGCCCATGCCTGTAGTCCCAGCTACTCAGGAGGCTCAGCAGCAGGACGACTTGAGCCCAAG
AGTTCCAGACCAGCCTGGCCACCTTAGTGAGATCCCTTCTCTTAAAAATAATAACTTATTGCCA
GATTTGGGGCATTTGGAAAGAAGTTCATTGAAGATAAAGCAAAAGTAAAAAAAAAAAAACAAGG
GGAAAGGGTTGGTTAGGCAATCATTCTAGGGCAGAAAGAAGTACAGGATAGGAAGAGCATAATA
CACTGTTTTTCTCAACAAGGAGCAGTATGTACACAGTCATAATGATGTGACTGCTTAGCCCCTA
AATATGGTAACTACTCTGGGACAATATGGGAGGAAAAGTGAAGATTGTGATGGTGTAAGAGCTA
AATCCTCATCTGTCATATCCAGAAATCACTATATAATATATAATAATGAAATGACTAAGTAGTT
ATGTGAGGAAAAAAACAGAAGACATTGCTAAAAGAGTTAAAAGTCATTGCTCTGGAGAATTAGG
AGGGATGGGGCAGGGGACTGTTAGGATGCATTATAAACTGAAAAGCCTTTTTAAAATGTTATGT
ATTAATATATGCATTCACTTAAAAAACTAAAAAAATAATAATAATTTGGAAAAACCCATGAAGG
TAACTAACGGAAGGAAAAACTAAGAGAATGAAAAGTATTTGCCTCTGGAAAGAACAACTGGCAG
GACTGTTGTTTTCATTGTAAGACTTTTGGAACCATTTAATTGTACTTAACCATTTTCATCTATT
TCTTTAATAAGAACAATTCCATCTTAATAAAGAGTTACACTTGTTCATAA

hide sequence

RefSeq Acc Id:

XM_008975788 ⟹ XP_008974036

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	4	34,653,485 - 34,681,917 (+)	NCBI
NHGRI_mPanPan1	5	32,807,110 - 32,835,542 (+)	NCBI
Mhudiblu_PPA_v0	5	34,663,210 - 34,689,467 (+)	NCBI
PanPan1.1	5	34,938,548 - 34,967,003 (+)	NCBI

Sequence:

show sequence

GCAACGCCGCGACCCTGCGTGCGCCGGGGCGGGGGGCGGGGCCTCGCCTGCACAAATAGGGACG
AGGGGGCGGGGCGGCCACAATTTCGCGCCAAACTTGACCGCGCGTTCTGCTGTAACGAGCGGGC
TCGGAGGTCCTCCCGCTGCTGTCATGGTTGGTTCGCTAAACTGCATCGTCGCTGTGTCCCAGAA
CATGGGCATCGGCAAGAACGGGGACCTGCCCTGGCCACCGCTCAGGAATGAATTCAGATATTTC
CAGAGAATGACCACAACCTCTTCAGTAGAAGGTAAACAGAATCTGGTGATTATGGGTAAGAAGA
CCTGGTTCTCCATTCCTGAGAAGAATCGACCTTTAAAGGGTAGAATTAATTTAGTTCTCAGCAG
AGAACTCAAGGAACCTCCACAAGGAGCTCATTTTCTTTCCAGAAGTCTAGATGATGCCTTAAAA
CTTACTGAACAACCAGAATTAGCAAGTAAAGTAGACATGGTCTGGATAGTTGGTGGCAGTTCTG
TTTATAAGGAAGCCATGAATCACCCAGGCCATCTTAAACTATTTGTGACAAGGATCATGCAAGA
CTTTGAAAGTGACACGTTTTTTCCAGAAATTGATTTGGAGAAATATAAACTTCTGCCAGAATAC
CCAGGTGTTCTCTCTGATGTCCAGGAGGAGAAAGGCATTAAGTACAAATTTGAAGTATATGAGA
AGAATGATTAATATGAAGGTGTTTTCTGGTTTAAGTTGTTCCCCCTCCCTCTGAAAAAAATACC
ATTTATGAGACATTCTTGCTATAACTAAGTGCTTCTCCAAGACCCCAACTGAGTCCCCAGCACC
TGCTACAGTGAGCTGCCATTCCACACCCATCACATGTGGCACTCCTGCCAGTCCTTGACATTGT
CGGGCTTTTCACATGTTGGTAACATTTATTAAAGATGAAGATCCACATACCCTTCAACTGAGCA
GTTTCACTAGTGGAAATACCAAAAGCTTCCTACGTGTATATCCAGAGGTTTGTAGATAAATGTT
GCCGCCTTGTTTGTAACAGTGAAAAATTGAAAACAACCTGGAAGTCCAGTGATGGGAAAATGAG
TATGTTTCTGTCTTAGATTGGGGAACCCAAAGCAGATTCCAAGACTGAAATTTCAGTGAAAGCA
GTTTATTTGCTAGGTCATACCAGAAATCATCAATTGAGGTATGGAGAAACTGAACTGAGAAGGT
AAGAAAAGCAATTTAAAGTCAGCGAGCAGGTTCTTATCGGTAACAAGCTCCCTACTGCTGAGAT
ACAGGGAAATGGAGGGGAGAAAGCTGGAGTATTGATCCCGTCCCCCTCCTTGGTTGTCAGCTCC
CTGTCCTGTGTGTGGGCGGAACATACTCTAGCTGCTCTATAGCAAGTCCCAGGTGTTTGCAGTA
AGAAGCTGCTGGCATGCACGGGAACAGTGAATGCCAAACACTTAAAGCAATTCGATGTTTAAGT
ATGTAAGTTCTTTTTTTTTAGACAGCGTTTCGCTCTTGTTGCCCAGGCTAGCATGCAATGGTGT
GACCTCGGCTTACTGCAACCTCCGCCTTCCCAGATTCAAGCGATTCTCCTGCCTCAGGCTCCCA
AGTAGCTAGGACCAGGCGTGTGCCACCACGCCCGGCTAATTTTTGTACTTTGTATTTTTAGTAG
AGATGGGGTTTCACCATGTTGGTTAGGCTAGTCTCAAACTCGTGACCGCAAGCGATTCACCCAC
CTCAGCCTCCCAAAGTGCTGGGATTACCGGCTTGAGCCACCACACCCGGCACATCTTCATTCTT
TTTATGTAGTAAAAAGTATAAGGTCACACATGGTTTATTTGAAGTATTTTATAATTTAAAAAAA
TACAGAAGCAGGAAAACCAATTCTAAGTTCAAGTGAGGGATGATGGTTGCTTGAACCAAAGGGT
TGCATGTAGTAAGAAATTGTGATTTAAGATATATTTTAAAGTTATAAGTAGCAGGATATTCTGA
TGGAGTTTGACTTTGGTTTTGGGCCCAAGGAGTTTCAGATGCCTTTGAGAAATGAATGAAGTAG
AGAGAAAATAAAAGAAAAACTAGCCAGGCACAGTGGCTCACACCTGTAATCCCAGTGCTTTGGG
AGGCTAAGGCAGGCAGATCACTTGAGACCAGCTTGGGCAACATGGCAAAGCCCCATCTCTACAA
AAAACACAAAAATTAGCTGGGCATTGTGGCGCACACCTGTATTCCCATCTACTCAGGAAGCTGA
GATGGAAGAATTAATTGAGCCCACGAGTTCAAGGCTGCAGTGAGTCGTGATTGTGCCACTGCAC
TCCAGCCGGGGTGACAGAAGAGACCTTGTCTCGAAAAGGAATCTGAAAACAATGGAACCATGCC
TTCATAATTCTAGAAAGTTATTTTCAACTGATAAATCTATATTCACCCAAATAATCAAGGGTGA
AGGTAAAATAATACATTTTTAGACAAGCAAAGACTCAGGGGTTGCCTCCATGTACCCGTTTTAG
GGAAGCTGTTGGAGAAAATACTCCAGCAAGATGAAGGCGTACACAAACCAGAGAATGGCATGGA
TCCAGCAAATAGCATCCAACACAGGCAATGTTCCAGCTATGGAGCTGGCTTTAAAAAGGAACAG
TAAAAATATTAATCGGTTAGCTGGGTGGAATGGCCCATGCCTGTAGTCCCAGCTACTCAGGAGG
CTCAGCAGCAGGACGACTTGAGCCCAAGAGTTCCAGACCAGCCTGGCCACCTTAGTGAGATCCC
TTCTCTTAAAAATAATAACTTATTGCCAGATTTGGGGCATTTGGAAAGAAGTTCATTGAAGATA
AAGCAAAAGTAAAAAAAAAAAAACAAGGGGAAAGGGTTGGTTAGGCAATCATTCTAGGGCAGAA
AGAAGTACAGGATAGGAAGAGCATAATACACTGTTTTTCTCAACAAGGAGCAGTATGTACACAG
TCATAATGATGTGACTGCTTAGCCCCTAAATATGGTAACTACTCTGGGACAATATGGGAGGAAA
AGTGAAGATTGTGATGGTGTAAGAGCTAAATCCTCATCTGTCATATCCAGAAATCACTATATAA
TATATAATAATGAAATGACTAAGTAGTTATGTGAGGAAAAAAACAGAAGACATTGCTAAAAGAG
TTAAAAGTCATTGCTCTGGAGAATTAGGAGGGATGGGGCAGGGGACTGTTAGGATGCATTATAA
ACTGAAAAGCCTTTTTAAAATGTTATGTATTAATATATGCATTCACTTAAAAAACTAAAAAAAT
AATAATAATTTGGAAAAACCCATGAAGGTAACTAACGGAAGGAAAAACTAAGAGAATGAAAAGT
ATTTGCCTCTGGAAAGAACAACTGGCAGGACTGTTGTTTTCATTGTAAGACTTTTGGAACCATT
TAATTGTACTTAACCATTTTCATCTATTTCTTTAATAAGAACAATTCCATCTTAATAAAGAGTT
ACACTTGTTCATAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003822315	(Get FASTA)	NCBI Sequence Viewer
	XP_008974036	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000008203.1
	ENSPPAP00000008206.1

RefSeq Acc Id:	XP_003822315 ⟸ XM_003822267
- Peptide Label:	isoform X2
- Sequence:	show sequence MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEK NRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELASKVDMVWIVGGSSVYKEAMNH PGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND hide sequence

RefSeq Acc Id:	XP_008974036 ⟸ XM_008975788
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R8ZTA3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEK NRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELASKVDMVWIVGGSSVYKEAMNH PGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND hide sequence

Ensembl Acc Id:

ENSPPAP00000008206 ⟸ ENSPPAT00000030841

Ensembl Acc Id:

ENSPPAP00000008203 ⟸ ENSPPAT00000030838

Protein Domains

DHFR

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000027338	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000030838.1	UniProtKB/TrEMBL
	ENSPPAT00000030841.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.430.10	UniProtKB/TrEMBL
InterPro	DHFR	UniProtKB/TrEMBL
	DHFR-like_dom_sf	UniProtKB/TrEMBL
	DHFR_CS	UniProtKB/TrEMBL
	DHFR_dom	UniProtKB/TrEMBL
KEGG Report	pps:100973672	UniProtKB/TrEMBL
NCBI Gene	DHFR	ENTREZGENE
PANTHER	DIHYDROFOLATE REDUCTASE	UniProtKB/TrEMBL
	PTHR48069	UniProtKB/TrEMBL
Pfam	DHFR_1	UniProtKB/TrEMBL
PRINTS	DHFR	UniProtKB/TrEMBL
PROSITE	DHFR_1	UniProtKB/TrEMBL
	DHFR_2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53597	UniProtKB/TrEMBL
UniProt	A0A2R8ZTA3	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R8ZWL7_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB