LOC100989368 (Kell metallo-endopeptidase (Kell blood group)) - Rat Genome Database

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Gene: LOC100989368 (Kell metallo-endopeptidase (Kell blood group)) Pan paniscus
Analyze
Symbol: LOC100989368 (Ensembl: TRPV5)
Name: Kell metallo-endopeptidase (Kell blood group) (Ensembl:transient receptor potential cation channel subfamily V member 5)
RGD ID: 11671015
Description: ENCODES a protein that exhibits calcium channel activity (inferred); calmodulin binding (inferred); hydrolase activity (inferred); INVOLVED IN calcium ion homeostasis (inferred); calcium ion import across plasma membrane (inferred); calcium ion transmembrane transport (inferred); ASSOCIATED WITH hemolytic disease of the fetus (ortholog); Vein of Galen Aneurysm (ortholog); FOUND IN apical plasma membrane (inferred); calcium channel complex (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: KEL; kell blood group glycoprotein; Kell blood group, metallo-endopeptidase; LOC117981144; transient receptor potential cation channel subfamily V member 5; TRPV5; uncharacterized LOC117981144
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26179,752,428 - 180,141,077 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1731,762,687 - 31,860,321 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07134,897,567 - 135,237,214 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17147,422,965 - 147,444,255 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7147,423,103 - 147,443,895 (-)Ensemblpanpan1.1panPan2
PanPan1.1 Ensembl7147,389,844 - 147,415,404 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LOC100989368
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26179,752,428 - 180,141,077 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1731,762,687 - 31,860,321 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07134,897,567 - 135,237,214 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17147,422,965 - 147,444,255 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7147,423,103 - 147,443,895 (-)Ensemblpanpan1.1panPan2
PanPan1.1 Ensembl7147,389,844 - 147,415,404 (-)Ensemblpanpan1.1panPan2
KEL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387142,941,114 - 142,962,363 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7142,941,114 - 142,962,363 (-)EnsemblGRCh38hg38GRCh38
GRCh377142,638,201 - 142,659,450 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367142,348,323 - 142,369,625 (-)NCBINCBI36Build 36hg18NCBI36
Build 347142,155,039 - 142,176,340NCBI
Celera7137,475,061 - 137,496,363 (-)NCBICelera
Cytogenetic Map7q34NCBI
HuRef7136,976,490 - 136,997,792 (-)NCBIHuRef
CHM1_17142,575,086 - 142,596,388 (-)NCBICHM1_1
T2T-CHM13v2.07144,296,525 - 144,394,915 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27142,040,072 - 142,061,375 (-)NCBI
Kel
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39641,663,263 - 41,681,268 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl641,663,264 - 41,681,273 (-)EnsemblGRCm39 Ensembl
GRCm38641,686,329 - 41,704,334 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl641,686,330 - 41,704,339 (-)EnsemblGRCm38mm10GRCm38
MGSCv37641,636,329 - 41,654,324 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36641,615,942 - 41,633,896 (-)NCBIMGSCv36mm8
Celera641,638,913 - 41,656,912 (-)NCBICelera
Cytogenetic Map6B2.1NCBI
cM Map619.86NCBI
Kel
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8471,534,882 - 71,552,297 (-)NCBIGRCr8
mRatBN7.2470,568,241 - 70,585,666 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl470,568,243 - 70,585,631 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx475,485,787 - 75,502,670 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0471,399,042 - 71,415,925 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0469,807,241 - 69,824,134 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0470,979,504 - 70,996,920 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl470,979,504 - 70,996,395 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04135,766,569 - 135,783,987 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4469,392,846 - 69,409,737 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera465,533,172 - 65,550,063 (-)NCBICelera
Cytogenetic Map4q23NCBI
Kel
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955494668,798 - 688,079 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955494668,188 - 688,036 (+)NCBIChiLan1.0ChiLan1.0
KEL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1166,396,724 - 6,645,221 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl166,623,824 - 6,645,094 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha167,535,089 - 7,558,835 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0166,250,137 - 6,556,234 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl166,536,981 - 6,556,219 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1166,197,531 - 6,509,648 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0166,049,436 - 6,361,088 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0166,124,842 - 6,419,811 (+)NCBIUU_Cfam_GSD_1.0
Kel
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511812,477,820 - 12,497,394 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936527406,132 - 427,186 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936527406,061 - 431,142 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KEL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl187,259,144 - 7,279,328 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1187,242,378 - 7,279,345 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2187,555,045 - 7,594,117 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KEL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121111,819,230 - 111,846,966 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21111,819,368 - 111,840,142 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660728,542,852 - 8,567,980 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kel
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480011,870,759 - 11,894,190 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480011,871,226 - 11,892,584 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000009341   ⟹   ENSPPAP00000001894
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl7147,423,103 - 147,443,895 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000037892   ⟹   ENSPPAP00000015203
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl7147,389,844 - 147,415,404 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000037903   ⟹   ENSPPAP00000015214
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl7147,390,374 - 147,415,213 (-)Ensembl
RefSeq Acc Id: XM_063606397   ⟹   XP_063462467
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v26179,752,428 - 180,141,077 (-)NCBI
Protein Sequences
Protein RefSeqs XP_063462467 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000001894.1
  ENSPPAP00000015203.1
  ENSPPAP00000015214.1
Ensembl Acc Id: ENSPPAP00000001894   ⟸   ENSPPAT00000009341
Ensembl Acc Id: ENSPPAP00000015203   ⟸   ENSPPAT00000037892
Ensembl Acc Id: ENSPPAP00000015214   ⟸   ENSPPAT00000037903
RefSeq Acc Id: XP_063462467   ⟸   XM_063606397
Protein Domains
Ion transport   Peptidase M13 C-terminal   Peptidase M13 N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000008525 Ensembl, UniProtKB/TrEMBL
  ENSPPAG00000030741 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000009341.1 UniProtKB/TrEMBL
  ENSPPAT00000037892.1 UniProtKB/TrEMBL
  ENSPPAT00000037903.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1380.10 UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Peptidase_M13 UniProtKB/TrEMBL
  Peptidase_M13_C UniProtKB/TrEMBL
  Peptidase_M13_dom_2 UniProtKB/TrEMBL
  Peptidase_M13_N UniProtKB/TrEMBL
  TRPV UniProtKB/TrEMBL
  TRPV5 UniProtKB/TrEMBL
  TRPV5/TRPV6 UniProtKB/TrEMBL
NCBI Gene KEL ENTREZGENE
PANTHER PTHR10582 UniProtKB/TrEMBL
  PTHR11733 UniProtKB/TrEMBL
  PTHR11733:SF128 UniProtKB/TrEMBL
  TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 5 UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
  Ion_trans UniProtKB/TrEMBL
  Peptidase_M13 UniProtKB/TrEMBL
  Peptidase_M13_N UniProtKB/TrEMBL
PRINTS ANKYRIN UniProtKB/TrEMBL
  ECACCHANNEL UniProtKB/TrEMBL
  ECACCHANNEL2 UniProtKB/TrEMBL
  NEPRILYSIN UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  NEPRILYSIN UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF48403 UniProtKB/TrEMBL
UniProt A0A2R8ZGW8_PANPA UniProtKB/TrEMBL
  A0A2R9AD42_PANPA UniProtKB/TrEMBL
  A0A2R9AI24_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-03-14 LOC100989368  Kell metallo-endopeptidase (Kell blood group)  LOC117981144  uncharacterized LOC117981144  Data Merged 737654 PROVISIONAL
2020-07-01 LOC100989368  Kell metallo-endopeptidase (Kell blood group)  KEL  Kell metallo-endopeptidase (Kell blood group)  Symbol and/or name change 5135510 APPROVED
2020-06-11 KEL  Kell metallo-endopeptidase (Kell blood group)  TRPV5  transient receptor potential cation channel subfamily V member 5  Data merged from RGD:11861374 737654 PROVISIONAL
2018-05-01 KEL  Kell metallo-endopeptidase (Kell blood group)    Kell blood group, metallo-endopeptidase  Symbol and/or name change 5135510 APPROVED