Nrxn1<sup>em1</sup> (neurexin 1; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs) - Rat Genome Database

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Gene: Nrxn1em1 (neurexin 1; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs) Rattus norvegicus
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Symbol: Nrxn1em1
Name: neurexin 1; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs
RGD ID: 11568059
Description: The ZFN mutant allele was produced by injecting zinc finger nuclease targeting rat Nrxn1 into Sprague Dawley embryos. The resulting mutation was a a 16-bp deletion in Exon 1.
ASSOCIATED WITH abnormal habituation to a new environment; decreased body weight; hyperactivity; ASSOCIATED WITH autism spectrum disorder
Type: allele  of Nrxn1  
Previously known as: Nrxn1tm1Sage; Nrxn1^[em1]; Nrxn1em1
Is Marker For: Strains:   SD-Nrxn1em1Sage  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phenotypic characterization of nonsocial behavioral impairment in neurexin 1a knockout rats. Esclassan F, etal., Behav Neurosci. 2015 Feb;129(1):74-85. doi: 10.1037/bne0000024. Epub 2014 Nov 24.

Genomics


Related Rat Strains
The following Strains have been annotated to Nrxn1em1


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information