Mecp2<sup>em1Sage</sup> (methyl CpG binding protein 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs)

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Gene: Mecp2^em1Sage (methyl CpG binding protein 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs) Rattus norvegicus

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Symbol:	Mecp2^em1Sage
Name:	methyl CpG binding protein 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs
RGD ID:	11568035
Description:	The ZFN mutant allele was produced by injecting zinc finger nuclease targeting rat Mecp2 into Sprague Dawley embryos. The resulting mutation was a knockout of the methyl CpG binding protein 2 (Mecp2) demonstrated by western blot. ASSOCIATED WITH abnormal action potential; abnormal motor coordination/balance; abnormal pulmonary respiratory rate; ASSOCIATED WITH Rett syndrome
Type:	allele of Mecp2
Previously known as:	Mecp2em1Sage; methyl CpG binding protein 2;zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs
Is Marker For:	Strains: SD-Mecp2^em1Sage
Latest Assembly:	mRatBN7.2 - mRatBN7.2 Assembly
Position:	No map positions available.

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Rett syndrome (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal action potential (IMP)

abnormal motor coordination/balance (IMP)

abnormal pulmonary respiratory rate (IMP)

abnormal response to social novelty (IMP)

abnormal scrotum morphology (IMP)

decreased body height (IMP)

decreased body weight (IMP)

decreased brain weight (IMP)

decreased grip strength (IMP)

decreased locomotor activity (IMP)

decreased pulmonary respiratory rate (IMP)

hyperpnea (IMP)

increased body weight (IMP)

increased pulmonary respiratory rate (IMP)

limb grasping (IMP)

malocclusion (IMP)

penis prolapse (IMP)

premature death (IMP)

progressive hair loss (IMP)

rough coat (IMP)

short stride length (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	MeCP2 deficiency results in robust Rett-like behavioural and motor deficits in male and female rats.	Patterson KC, etal., Hum Mol Genet. 2016 Aug 1;25(15):3303-3320. doi: 10.1093/hmg/ddw179. Epub 2016 Jun 21.
2.	MeCP2 deficiency results in robust Rett-like behavioural and motor deficits in male and female rats.	Patterson KC, etal., Hum Mol Genet. 2016 Dec 15;25(24):5514-5515. doi: 10.1093/hmg/ddw435.
3.	Loss of MeCP2 in the rat models regression, impaired sociability and transcriptional deficits of Rett syndrome.	Veeraragavan S, etal., Hum Mol Genet. 2016 Jun 30. pii: ddw178.
4.	Characterization of Rett Syndrome-like phenotypes in Mecp2-knockout rats.	Wu Y, etal., J Neurodev Disord. 2016 Jun 16;8:23. doi: 10.1186/s11689-016-9156-7. eCollection 2016.

Genomics

Related Rat Strains

The following Strains have been annotated to Mecp2^em1Sage

SD-Mecp2^em1Sage

Expression

Sequence

Nucleotide Sequences

Additional Information

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-12-07	Mecp2^em1Sage	methyl CpG binding protein 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs	Mecp2^em1Sage	methyl CpG binding protein 2;zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs	Name changed	629549	APPROVED

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MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Mammalian Phenotype