Mecp2<sup>em1Sage</sup> (methyl CpG binding protein 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs) - Rat Genome Database

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Gene: Mecp2em1Sage (methyl CpG binding protein 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs) Rattus norvegicus
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Symbol: Mecp2em1Sage
Name: methyl CpG binding protein 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs
RGD ID: 11568035
Description: The ZFN mutant allele was produced by injecting zinc finger nuclease targeting rat Mecp2 into Sprague Dawley embryos. The resulting mutation was a knockout of the methyl CpG binding protein 2 (Mecp2) demonstrated by western blot.
ASSOCIATED WITH abnormal action potential; abnormal motor coordination/balance; abnormal pulmonary respiratory rate; ASSOCIATED WITH Rett syndrome
Type: allele  of Mecp2  
Previously known as: Mecp2^[em1Sage]; Mecp2em1Sage; methyl CpG binding protein 2;zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs
Is Marker For: Strains:   SD-Mecp2em1Sage  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References

References - curated
# Reference Title Reference Citation
1. MeCP2 deficiency results in robust Rett-like behavioural and motor deficits in male and female rats. Patterson KC, etal., Hum Mol Genet. 2016 Aug 1;25(15):3303-3320. doi: 10.1093/hmg/ddw179. Epub 2016 Jun 21.
2. MeCP2 deficiency results in robust Rett-like behavioural and motor deficits in male and female rats. Patterson KC, etal., Hum Mol Genet. 2016 Dec 15;25(24):5514-5515. doi: 10.1093/hmg/ddw435.
3. Loss of MeCP2 in the rat models regression, impaired sociability and transcriptional deficits of Rett syndrome. Veeraragavan S, etal., Hum Mol Genet. 2016 Jun 30. pii: ddw178.
4. Characterization of Rett Syndrome-like phenotypes in Mecp2-knockout rats. Wu Y, etal., J Neurodev Disord. 2016 Jun 16;8:23. doi: 10.1186/s11689-016-9156-7. eCollection 2016.

Genomics


Related Rat Strains
The following Strains have been annotated to Mecp2em1Sage
SD-Mecp2em1Sage    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-12-07 Mecp2em1Sage  methyl CpG binding protein 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs  Mecp2em1Sage  methyl CpG binding protein 2;zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs  Name changed 629549 APPROVED