Mecp2<sup>em1Sage</sup> (methyl CpG binding protein 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs) - Rat Genome Database

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Gene: Mecp2em1Sage (methyl CpG binding protein 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs) Rattus norvegicus
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Symbol: Mecp2em1Sage
Name: methyl CpG binding protein 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs
RGD ID: 11568035
Description: The ZFN mutant allele was produced by injecting zinc finger nuclease targeting rat Mecp2 into Sprague Dawley embryos. The resulting mutation was a knockout of the methyl CpG binding protein 2 (Mecp2) demonstrated by western blot.
ASSOCIATED WITH abnormal action potential; abnormal motor coordination/balance; abnormal pulmonary respiratory rate; ASSOCIATED WITH Rett syndrome
Type: allele  of Mecp2  
Previously known as: Mecp2em1Sage; methyl CpG binding protein 2;zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs
Is Marker For: Strains:   SD-Mecp2em1Sage  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References

References - curated
# Reference Title Reference Citation
1. MeCP2 deficiency results in robust Rett-like behavioural and motor deficits in male and female rats. Patterson KC, etal., Hum Mol Genet. 2016 Aug 1;25(15):3303-3320. doi: 10.1093/hmg/ddw179. Epub 2016 Jun 21.
2. MeCP2 deficiency results in robust Rett-like behavioural and motor deficits in male and female rats. Patterson KC, etal., Hum Mol Genet. 2016 Dec 15;25(24):5514-5515. doi: 10.1093/hmg/ddw435.
3. Loss of MeCP2 in the rat models regression, impaired sociability and transcriptional deficits of Rett syndrome. Veeraragavan S, etal., Hum Mol Genet. 2016 Jun 30. pii: ddw178.
4. Characterization of Rett Syndrome-like phenotypes in Mecp2-knockout rats. Wu Y, etal., J Neurodev Disord. 2016 Jun 16;8:23. doi: 10.1186/s11689-016-9156-7. eCollection 2016.

Genomics


Related Rat Strains
The following Strains have been annotated to Mecp2em1Sage


Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-12-07 Mecp2em1Sage  methyl CpG binding protein 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs  Mecp2em1Sage  methyl CpG binding protein 2;zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs  Name changed 629549 APPROVED