Ttn<sup>em2Sage</sup> (Titin; zinc finger nuclease induced mutant 2,Sigma Advanced Genetic Engineering Labs) - Rat Genome Database

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Gene: Ttnem2Sage (Titin; zinc finger nuclease induced mutant 2,Sigma Advanced Genetic Engineering Labs) Rattus norvegicus
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Symbol: Ttnem2Sage
Name: Titin; zinc finger nuclease induced mutant 2,Sigma Advanced Genetic Engineering Labs
RGD ID: 11565827
Description: The zinc-finger nuclease mediated genome editing system created a deletion of exons 2-6 (5,286-bp deletion, coordinates 2,323-7,608) to introduce a frameshift (Rnor_5.0).
ASSOCIATED WITH abnormal cardiac muscle contractility; decreased cardiac muscle relaxation; decreased cardiac stroke volume
Type: allele  of Ttn  
Previously known as: Titin; zinc finger nuclease induced mutant2,Sigma Advanced Genetic Engineering Labs; Ttn^[em2Sage]; Ttnem2Sage; TTNtvZ
Is Marker For: Strains:   F344-Ttnem2Sage  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position: No map positions available.




Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Titin-truncating variants affect heart function in disease cohorts and the general population. Schafer S, etal., Nat Genet. 2016 Nov 21. doi: 10.1038/ng.3719.

Genomics


Related Rat Strains
The following Strains have been annotated to Ttnem2Sage
F344-Ttnem2Sage    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-11-28 Ttnem2Sage  Titin; zinc finger nuclease induced mutant 2,Sigma Advanced Genetic Engineering Labs  Ttnem2Sage  Titin; zinc finger nuclease induced mutant2,Sigma Advanced Genetic Engineering Labs  Name changed 629549 APPROVED