Aspa<sup>em34Kyo</sup> (aspartoacylase;TALEN induced mutant 34,Kyo) - Rat Genome Database

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Gene: Aspaem34Kyo (aspartoacylase;TALEN induced mutant 34,Kyo) Rattus norvegicus
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Symbol: Aspaem34Kyo
Name: aspartoacylase;TALEN induced mutant 34,Kyo
RGD ID: 11564348
Description: TALEN targeting the exon4 of Aspartoacylase (Aspa) gene was designed and mRNA coding these TALEN was microinjected into F344/NSlc embyo. The TALEN system caused a 16-bp deletion in the exon4 of Aspa gene, as a result created a premature stop codon in the gene.
ASSOCIATED WITH brain vacuoles; dysmyelination; ASSOCIATED WITH essential tremor; Tremor
Type: allele  of Aspa  
Previously known as: Aspaem34Kyo
Is Marker For: Strains:   F344-Aspaem34Kyo   STOCK Aspaem34Kyo Hcn1A354V/Kyo   F344 -Aspaem34Kyo Hcn1em1Kyo  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View
essential tremor  (IGI)
Tremor  (IMP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Involvement of aspartoacylase in tremor expression in rats. Nishitani A, etal., Exp Anim. 2016 Jul 29;65(3):293-301. doi: 10.1538/expanim.16-0007. Epub 2016 Mar 30.
2. Involvement of NMDA receptors in tremor expression in Aspa/Hcn1 double-knockout rats. Nishitani A, etal., Exp Anim. 2020 Nov 12;69(4):388-394. doi: 10.1538/expanim.20-0025. Epub 2020 Jun 5.
3. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP

Genomics


Related Rat Strains
The following Strains have been annotated to Aspaem34Kyo


Expression


Sequence

Nucleotide Sequences


Additional Information