Shc1<sup>em5Mcwi</sup> (SHC adaptor protein 1; ZFN induced mutant 5, Medical College of Wisconsin) - Rat Genome Database

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Gene: Shc1em5Mcwi (SHC adaptor protein 1; ZFN induced mutant 5, Medical College of Wisconsin) Rattus norvegicus
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Symbol: Shc1em5Mcwi
Name: SHC adaptor protein 1; ZFN induced mutant 5, Medical College of Wisconsin
RGD ID: 11553915
Description: This allele was made by ZFN system. The resulting mutation is a T>C substitution to generate S36A in Exon 2 of theShc1 gene
ASSOCIATED WITH decreased tubuloglomerular feedback response; ASSOCIATED WITH Hypertensive Nephropathy
Type: allele  of Shc1  
Previously known as: p66Shctm1(S36A)Mcwi; SHC adaptor protein 1; ZFN induced mutant 1 (S36A), Medical College of Wisconsin; Shc1em1(S36A)Mcwi; Shc1^[em5Mcwi]; Shc1em5Mcwi
Is Marker For: Strains:   SS-Shc1em5Mcwi  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. p66Shc regulates renal vascular tone in hypertension-induced nephropathy. Miller B, etal., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6.

Genomics


Related Rat Strains
The following Strains have been annotated to Shc1em5Mcwi
SS-Shc1em5Mcwi    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-01-25 Shc1em5Mcwi  SHC adaptor protein 1; ZFN induced mutant 5, Medical College of Wisconsin  Shc1em1(S36A)Mcwi  SHC adaptor protein 1; ZFN induced mutant 1 (S36A), Medical College of Wisconsin  Name and Symbol changed 629549 APPROVED
2016-10-17 Shc1em1(S36A)Mcwi  SHC adaptor protein 1; ZFN induced mutant 1 (S36A), Medical College of Wisconsin  Shcem1(S36A)Mcwi  SHC adaptor protein 1; ZFN induced mutant 1 (S36A), Medical College of Wisconsin  Symbol changed 629549 APPROVED