Shc1<sup>em5Mcwi</sup> (SHC adaptor protein 1; ZFN induced mutant 5, Medical College of Wisconsin) - Rat Genome Database

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Gene: Shc1em5Mcwi (SHC adaptor protein 1; ZFN induced mutant 5, Medical College of Wisconsin) Rattus norvegicus
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Symbol: Shc1em5Mcwi
Name: SHC adaptor protein 1; ZFN induced mutant 5, Medical College of Wisconsin
RGD ID: 11553915
Description: This allele was made by ZFN system. The resulting mutation is a T>C substitution to generate S36A in Exon 2 of theShc1 gene
ASSOCIATED WITH decreased tubuloglomerular feedback response; ASSOCIATED WITH Hypertensive Nephropathy
Type: allele  of Shc1  
Previously known as: p66Shctm1(S36A)Mcwi; SHC adaptor protein 1; ZFN induced mutant 1 (S36A), Medical College of Wisconsin; Shc1em1(S36A)Mcwi; Shc1^[em5Mcwi]; Shc1em5Mcwi
Is Marker For: Strains:   SS-Shc1em5Mcwi  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. p66Shc regulates renal vascular tone in hypertension-induced nephropathy. Miller B, etal., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6.

Genomics


Related Rat Strains
The following Strains have been annotated to Shc1em5Mcwi


Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-01-25 Shc1em5Mcwi  SHC adaptor protein 1; ZFN induced mutant 5, Medical College of Wisconsin  Shc1em1(S36A)Mcwi  SHC adaptor protein 1; ZFN induced mutant 1 (S36A), Medical College of Wisconsin  Name and Symbol changed 629549 APPROVED
2016-10-17 Shc1em1(S36A)Mcwi  SHC adaptor protein 1; ZFN induced mutant 1 (S36A), Medical College of Wisconsin  Shcem1(S36A)Mcwi  SHC adaptor protein 1; ZFN induced mutant 1 (S36A), Medical College of Wisconsin  Symbol changed 629549 APPROVED