Trpc6<sup>em1Mcwi</sup> (transient receptor potential cation channel, subfamily C, member 6; CRISPR/Cas9 induced mutant 1, Medical College of Wisconsin) - Rat Genome Database

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Gene: Trpc6em1Mcwi (transient receptor potential cation channel, subfamily C, member 6; CRISPR/Cas9 induced mutant 1, Medical College of Wisconsin) Rattus norvegicus
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Symbol: Trpc6em1Mcwi
Name: transient receptor potential cation channel, subfamily C, member 6; CRISPR/Cas9 induced mutant 1, Medical College of Wisconsin
RGD ID: 11553911
Description: This allele was made by CRISPR/Cas9 system. The resulting mutation is a 2-bp insertion in Exon 2 of the Trpc6 gene.
ASSOCIATED WITH decreased body weight; decreased creatinine clearance; glomerulosclerosis; ASSOCIATED WITH Diabetic Nephropathies
Type: allele  of Trpc6  
Previously known as: Trpc6^[em1Mcwi]; Trpc6em1Mcwi
Is Marker For: Strains:   SS-Trpc6em1Mcwi  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Protective role of Trpc6 knockout in the progression of diabetic kidney disease. Spires D, etal., Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F1091-F1097. doi: 10.1152/ajprenal.00155.2018. Epub 2018 Jun 20.

Genomics


Related Rat Strains
The following Strains have been annotated to Trpc6em1Mcwi
SS-Trpc6em1Mcwi    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information