Fmr1<sup>em2Mcwi</sup> (FMRP translational regulator 1; CRISPR/Cas9 induced mutant 2, Medical College of Wisconsin) - Rat Genome Database

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Gene: Fmr1em2Mcwi (FMRP translational regulator 1; CRISPR/Cas9 induced mutant 2, Medical College of Wisconsin) Rattus norvegicus
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Symbol: Fmr1em2Mcwi
Name: FMRP translational regulator 1; CRISPR/Cas9 induced mutant 2, Medical College of Wisconsin
RGD ID: 11553872
Description: This allele was made by CRISPR/Cas9 system. The resulting mutation is a 2-bp insertion in exon 7 of the Fmr1 gene.
ASSOCIATED WITH abnormal spike wave discharge; hyperactivity; impaired short-term object recognition memory
Type: allele  of Fmr1  
Previously known as: Fmr1^[em2Mcwi]; Fmr1em2Mcwi; fragile X mental retardation 1; CRISPR/Cas9 induced mutant 2, Medical College of Wisconsin
Is Marker For: Strains:   LE-Fmr1em2Mcwi  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position: No map positions available.


References

References - curated
# Reference Title Reference Citation
1. Rescue of sharp wave-ripples and prevention of network hyperexcitability in the ventral but not the dorsal hippocampus of a rat model of fragile X syndrome. Leontiadis LJ, etal., Front Cell Neurosci. 2023 Dec 1;17:1296235. doi: 10.3389/fncel.2023.1296235. eCollection 2023.
2. Robust and replicable measurement for prepulse inhibition of the acoustic startle response. Miller EA, etal., Mol Psychiatry. 2020 Mar 6. pii: 10.1038/s41380-020-0703-y. doi: 10.1038/s41380-020-0703-y.
3. Multi-level profiling of the Fmr1 KO rat unveils altered behavioral traits along with aberrant glutamatergic function. Ntoulas G, etal., Transl Psychiatry. 2024 Feb 20;14(1):104. doi: 10.1038/s41398-024-02815-0.

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Fmr1em2Mcwi-var1 chrX 154703634 154703635 AG GCA delins Rnor_6.0

Related Rat Strains
The following Strains have been annotated to Fmr1em2Mcwi


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-26 Fmr1em2Mcwi  FMRP translational regulator 1; CRISPR/Cas9 induced mutant 2, Medical College of Wisconsin  Fmr1em2Mcwi  fragile X mental retardation 1; CRISPR/Cas9 induced mutant 2, Medical College of Wisconsin  Name changed 629549 APPROVED