Atp7b<sup>hts</sup> (ATPase copper transporting beta; hepatitis) - Rat Genome Database

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Gene: Atp7bhts (ATPase copper transporting beta; hepatitis) Rattus norvegicus
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Symbol: Atp7bhts
Name: ATPase copper transporting beta; hepatitis
RGD ID: 11532742
Description: This allele is a spontaneously deletion mutant found in LEC rats. The deletion removes at least 900 bp of the coding region at the 3' end, includes the crucial ATP binding domain and extends downstream of the gene.
ASSOCIATED WITH abnormal renal tubule morphology; decreased body weight; decreased circulating copper level; ASSOCIATED WITH liver carcinoma; Liver Neoplasms; renal adenoma
Type: allele  of Atp7b  
Previously known as: Atp7b^[hts]; Atp7bhts; Atphts; ATPase copper transporting beta, hepatitis
Is Marker For: Strains:   LEC/Hok   WKAH.LEC-Atp7bhts/Tj   LEC/Tj  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position: No map positions available.


References

References - curated
# Reference Title Reference Citation
1. Therapeutic potential of hepatocyte-like-cells converted from stem cells from human exfoliated deciduous teeth in fulminant Wilson's disease. Fujiyoshi J, etal., Sci Rep. 2019 Feb 7;9(1):1535. doi: 10.1038/s41598-018-38275-y.
2. Maturational arrest of thymocyte development is caused by a deletion in the receptor-like protein tyrosine phosphatase kappa gene in LEC rats. Kose H, etal., Genomics. 2007 Jun;89(6):673-7. doi: 10.1016/j.ygeno.2007.03.001. Epub 2007 Apr 16.
3. Abnormal hepatobiliary and circulating lipid metabolism in the Long-Evans Cinnamon rat model of Wilson's disease. Levy E, etal., Life Sci. 2007 Mar 27;80(16):1472-83. Epub 2007 Jan 20.
4. Spontaneous hepatic copper accumulation in Long-Evans Cinnamon rats with hereditary hepatitis. A model of Wilson's disease. Li Y, etal., J Clin Invest. 1991 May;87(5):1858-61. doi: 10.1172/JCI115208.
5. Hereditary hepatitis of LEC rats is controlled by a single autosomal recessive gene. Masuda R, etal., Lab Anim. 1988 Apr;22(2):166-9. doi: 10.1258/002367788780864402.
6. Role of Atp7b gene in spontaneous and N-diethylnitrosamine-induced carcinogenesis in a new congenic strain, WKAH.C-Atp7b rats. Minami T, etal., Jpn J Cancer Res 2001 Aug;92(8):841-7.
7. The LEC rat: a model for human hepatitis, liver cancer, and much more. Mori M, etal., Am J Pathol. 1994 Jan;144(1):200-4.
8. Inherited copper toxicity in Long-Evans cinnamon rats exhibiting spontaneous hepatitis: a model of Wilson's disease. Okayasu T, etal., Pediatr Res. 1992 Mar;31(3):253-7. doi: 10.1203/00006450-199203000-00011.
9. Evolution of exchangeable copper and relative exchangeable copper through the course of Wilson's disease in the Long Evans Cinnamon rat. Schmitt F, etal., PLoS One. 2013 Dec 17;8(12):e82323. doi: 10.1371/journal.pone.0082323. eCollection 2013.
10. The LEC rat has a deletion in the copper transporting ATPase gene homologous to the Wilson disease gene. Wu J, etal., Nat Genet 1994 Aug;7(4):541-5.
11. New mutation causing hereditary hepatitis in the laboratory rat. Yoshida MC, etal., J Hered 1987 Nov-Dec;78(6):361-5.

Genomics


Related Rat Strains
The following Strains have been annotated to Atp7bhts
LEC/Hok     LEC/Tj     WKAH.LEC-Atp7bhts/Tj    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-04-03 Atp7bhts  ATPase copper transporting beta; hepatitis  Atp7bhts  ATPase copper transporting beta, hepatitis  Name changed 629549 APPROVED
2017-07-21 Atp7bhts  ATPase copper transporting beta, hepatitis  Atphts  ATPase copper transporting beta, hepatitis  Data merged from RGD:11532743 737654 PROVISIONAL
2017-02-27 Atp7bhts  ATPase copper transporting beta, hepatitis  Atphts  ATPase copper transporting beta, hepatitis  Symbol changed 629549 APPROVED
2016-09-06 Atphts  ATPase copper transporting beta, hepatitis  Atphts  ATPase copper transporting beta, hepatitis  Type changed (type changed from [gene] to [allele]) 629549 APPROVED