F8<i><sup>em1Sage</sup></i> (coagulation factor VIII, procoagulant component; zinc finger nuclease induced mutant1, Sage) - Rat Genome Database

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Gene: F8em1Sage (coagulation factor VIII, procoagulant component; zinc finger nuclease induced mutant1, Sage) Rattus norvegicus
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Symbol: F8em1Sage
Name: coagulation factor VIII, procoagulant component; zinc finger nuclease induced mutant1, Sage
RGD ID: 11531096
Description: This F8 mutant allele carrying a 13-bp deletion in exon 16 causing a premature translation stop in the C-terminal part of the A3 domain.
ASSOCIATED WITH abnormal bone remodeling; abnormal hemostasis; decreased circulating serum albumin level; ASSOCIATED WITH factor VIII deficiency; hemarthrosis; Hemophilic Arthropathy
Type: allele  of F8  
Previously known as: coagulation factor VIII, procoagulant component; F8em1Sage; zinc finger nuclease induced mutant1, Sage, Ycb
Is Marker For: Strains:   SD-F8em1Sage+/-/Novo   SD-F8em1Sage/Novo   SD-F8em1Sage-/-/Novo   SD-F8em1Sage/Novo-Tg(ITGA2B-F8*)Mcwi  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A novel F8 -/- rat as a translational model of human hemophilia A. Nielsen LN, etal., J Thromb Haemost. 2014 Aug;12(8):1274-82. doi: 10.1111/jth.12635.
2. The severe spontaneous bleeding phenotype in a novel hemophilia A rat model is rescued by platelet FVIII expression. Shi Q, etal., Blood Adv. 2020 Jan 14;4(1):55-65. doi: 10.1182/bloodadvances.2019000944.
3. The F8(-/-) rat as a model of hemophilic arthropathy. Sørensen KR, etal., J Thromb Haemost. 2016 Jun;14(6):1216-25. doi: 10.1111/jth.13328. Epub 2016 May 10.

Genomics


Related Rat Strains
The following Strains have been annotated to F8em1Sage


Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-25 F8em1Sage  coagulation factor VIII, procoagulant component; zinc finger nuclease induced mutant1, Sage  F8em1Sage  coagulation factor VIII, procoagulant component; zinc finger nuclease induced mutant1, Sage, Ycb  Name and Type changed (type changed from [gene] to [allele]) 629549 APPROVED