Yy1 (YY1 transcription factor) - Rat Genome Database

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Gene: Yy1 (YY1 transcription factor) Mus musculus
Analyze
Symbol: Yy1
Name: YY1 transcription factor
RGD ID: 11500
MGI Page MGI
Description: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including DNA metabolic process; regulation of nucleobase-containing compound metabolic process; and response to UV-C. Acts upstream of or within with a positive effect on gene expression. Acts upstream of or within several processes, including anterior/posterior pattern specification; camera-type eye morphogenesis; and regulation of gene expression. Located in nucleus. Part of chromatin; nucleus; and transcription regulator complex. Is expressed in several structures, including central nervous system; early conceptus; eye; hemolymphoid system gland; and reproductive system. Used to study pleuropulmonary blastoma. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human YY1 (YY1 transcription factor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW488674; delta transcription factor; NF-E; NF-E1; transcriptional repressor protein YY1; UCR-motif DNA-binding protein; UCRBP transcription factor; yin and yang 1; Yin Yang 1; YY-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912108,758,841 - 108,786,074 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12108,758,899 - 108,786,074 (+)EnsemblGRCm39 Ensembl
GRCm3812108,792,945 - 108,820,148 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12108,792,973 - 108,820,148 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712110,031,521 - 110,054,842 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612109,241,118 - 109,264,439 (+)NCBIMGSCv36mm8
Celera12110,029,534 - 110,052,930 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1259.58NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R,R,R)-alpha-tocopherol  (ISO)
1,2-dimethylhydrazine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (ISO)
2-arachidonoylglycerol  (EXP)
2-ethoxyethanol  (ISO)
2-methoxyethanol  (ISO)
2-methylcholine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP)
alpha-pinene  (ISO)
AM-251  (EXP)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
artesunate  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
cadmium sulfate  (ISO)
calyculin a  (EXP)
choline  (EXP)
cisplatin  (EXP)
clobetasol  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cypermethrin  (EXP,ISO)
D-glucose  (EXP,ISO)
decabromodiphenyl ether  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
flutamide  (ISO)
folic acid  (EXP)
fulvestrant  (ISO)
gentamycin  (ISO)
glucose  (EXP,ISO)
hesperidin  (ISO)
hydrogen peroxide  (EXP,ISO)
isoprenaline  (EXP)
ketamine  (ISO)
L-methionine  (EXP)
lead diacetate  (ISO)
lead(II) chloride  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (EXP)
methapyrilene  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
ozone  (ISO)
paracetamol  (EXP)
phenethyl caffeate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
potassium chloride  (ISO)
rotenone  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
troglitazone  (EXP)
valproic acid  (EXP,ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (IGI,IMP)
B cell differentiation  (IMP)
camera-type eye morphogenesis  (IGI)
cell differentiation  (IEA)
cellular response to interleukin-1  (ISO)
cellular response to UV  (ISO)
chromatin remodeling  (ISO)
chromosome organization  (IMP)
DNA damage response  (IMP,ISO)
DNA recombination  (IEA)
DNA repair  (IEA)
double-strand break repair via homologous recombination  (ISO)
gene expression  (IDA)
hemopoiesis  (IMP)
immunoglobulin heavy chain V-D-J recombination  (IMP)
negative regulation of cell growth involved in cardiac muscle cell development  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of interferon-beta production  (ISO)
negative regulation of miRNA transcription  (IDA)
negative regulation of transcription by RNA polymerase II  (IDA,ISO)
positive regulation of DNA repair  (IDA)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of gene expression  (IDA)
positive regulation of telomere maintenance in response to DNA damage  (IMP)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of cell cycle  (ISO)
regulation of chromosome organization  (ISO)
regulation of DNA repair  (IDA)
regulation of DNA replication  (ISO)
regulation of DNA strand elongation  (ISO)
regulation of DNA-templated transcription  (IDA,ISO)
regulation of embryonic development  (IMP)
regulation of transcription by RNA polymerase II  (IBA,ISO)
response to prostaglandin F  (ISO)
response to UV-C  (IMP,ISO)
RNA localization  (IMP)
spermatogenesis  (IMP)
telomere maintenance  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal airway basal cell morphology  (IAGP)
abnormal branching involved in lung morphogenesis  (IAGP)
abnormal circulating hormone level  (IAGP)
abnormal coat/hair pigmentation  (IAGP)
abnormal dorsoventral coat patterning  (IAGP)
abnormal endoderm development  (IAGP)
abnormal extraembryonic ectoderm morphology  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal gastrulation  (IAGP)
abnormal gastrulation movements  (IAGP)
abnormal hair follicle melanin granule morphology  (IAGP)
abnormal hair follicle melanocyte morphology  (IAGP)
abnormal lung development  (IAGP)
abnormal lung epithelium morphology  (IAGP)
abnormal lung morphology  (IAGP)
abnormal lung-associated mesenchyme development  (IAGP)
abnormal melanoblast morphology  (IAGP)
abnormal mesoderm development  (IAGP)
abnormal oocyte morphology  (IAGP)
abnormal ovary physiology  (IAGP)
abnormal primitive streak elongation  (IAGP)
abnormal primitive streak formation  (IAGP)
abnormal respiratory epithelium physiology  (IAGP)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal secondary ovarian follicle morphology  (IAGP)
abnormal trachea morphology  (IAGP)
abnormal tracheal cartilage morphology  (IAGP)
abnormal tracheal ciliated epithelium morphology  (IAGP)
abnormal visceral endoderm morphology  (IAGP)
absent egg cylinders  (IAGP)
absent estrous cycle  (IAGP)
absent hair follicle melanin granules  (IAGP)
absent head fold  (IAGP)
absent mature ovarian follicles  (IAGP)
absent notochord  (IAGP)
absent primitive node  (IAGP)
absent tertiary ovarian follicles  (IAGP)
cyanosis  (IAGP)
decreased birth body size  (IAGP)
decreased cell proliferation  (IAGP)
decreased club cell number  (IAGP)
decreased copulatory plug deposition  (IAGP)
decreased embryo size  (IAGP)
decreased melanocyte number  (IAGP)
decreased respiratory mucosa goblet cell number  (IAGP)
decreased secondary ovarian follicle number  (IAGP)
decreased skin pigmentation  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
exencephaly  (IAGP)
female infertility  (IAGP)
impaired myofibroblast differentiation  (IAGP)
impaired ovarian folliculogenesis  (IAGP)
increased blastoma incidence  (IAGP)
increased circulating follicle stimulating hormone level  (IAGP)
increased lung apoptosis  (IAGP)
increased primary ovarian follicle number  (IAGP)
left pulmonary isomerism  (IAGP)
lethality at weaning, complete penetrance  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
lung cyst  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
oocyte degeneration  (IAGP)
pallor  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
respiratory failure  (IAGP)
small ovary  (IAGP)
trachea stenosis  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Interplay between heme oxygenase-1 and the multifunctional transcription factor yin yang 1 in the inhibition of intimal hyperplasia. Beck K, etal., Circ Res. 2010 Dec 10;107(12):1490-7. doi: 10.1161/CIRCRESAHA.110.231985. Epub 2010 Oct 28.
2. A role for E2F6 in distinguishing G1/S- and G2/M-specific transcription. Giangrande PH, etal., Genes Dev 2004 Dec 1;18(23):2941-51.
3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
4. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
5. Genetic variation in the multifunctional transcription factor Yy1 and type 1 diabetes mellitus in the BB rat. Kloting N and Kloting I, Mol Genet Metab. 2004 Jul;82(3):255-9.
6. Diabetes per se and metabolic state influence gene expression in tissue-dependent manner of BB/OK rats. Kloting N, etal., Diabetes Metab Res Rev. 2005 May-Jun;21(3):281-7.
7. Yin Yang 1 represses alpha-myosin heavy chain gene expression in pathologic cardiac hypertrophy. Mariner PD, etal., Biochem Biophys Res Commun. 2005 Jan 7;326(1):79-86.
8. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
9. MGDs mouse GO annotations MGD data from the GO Consortium
10. MGD IEA MGD IEA
11. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Induction of the transcriptional repressor Yin Yang-1 by vascular cell injury. Autocrine/paracrine role of endogenous fibroblast growth factor-2. Santiago FS, etal., J Biol Chem 2001 Nov 2;276(44):41143-9.
17. Yin Yang 1 is increased in human heart failure and represses the activity of the human alpha-myosin heavy chain promoter. Sucharov CC, etal., J Biol Chem. 2003 Aug 15;278(33):31233-9. Epub 2003 May 16.
18. The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics. Watanabe S and Peterson CL, Cold Spring Harb Symp Quant Biol. 2010;75:35-42. doi: 10.1101/sqb.2010.75.063. Epub 2011 Apr 18.
Additional References at PubMed
PMID:1309593   PMID:1946404   PMID:7806016   PMID:7912122   PMID:8056143   PMID:8114709   PMID:8149907   PMID:8516301   PMID:8889548   PMID:8917507   PMID:8976384   PMID:9038208  
PMID:9141463   PMID:9173930   PMID:9624122   PMID:9747880   PMID:9857059   PMID:10349636   PMID:10490658   PMID:10680598   PMID:11042159   PMID:11076861   PMID:11861914   PMID:11907091  
PMID:12135926   PMID:12393438   PMID:12477932   PMID:12520002   PMID:12527199   PMID:12584314   PMID:12688534   PMID:12723621   PMID:12759432   PMID:12802082   PMID:12808092   PMID:12904583  
PMID:14610273   PMID:14681479   PMID:15013809   PMID:15161869   PMID:15489334   PMID:15499019   PMID:15563837   PMID:15610523   PMID:16141072   PMID:16141073   PMID:16260628   PMID:16452489  
PMID:16611997   PMID:16624538   PMID:17001316   PMID:17067777   PMID:17093407   PMID:17107999   PMID:17218270   PMID:17220375   PMID:17250610   PMID:17438126   PMID:17504937   PMID:17513763  
PMID:17640524   PMID:17641042   PMID:17901046   PMID:17967808   PMID:17977899   PMID:18024232   PMID:18026119   PMID:18046414   PMID:18046543   PMID:18068135   PMID:18092359   PMID:18287559  
PMID:18423564   PMID:18485096   PMID:18584324   PMID:18694725   PMID:18799693   PMID:19013134   PMID:19129193   PMID:19536159   PMID:19542223   PMID:19628663   PMID:19638226   PMID:19712462  
PMID:19786570   PMID:20059953   PMID:20412781   PMID:20431063   PMID:20660740   PMID:20720167   PMID:20843790   PMID:21057508   PMID:21123818   PMID:21149256   PMID:21233130   PMID:21267068  
PMID:21282644   PMID:21454521   PMID:21606361   PMID:21677750   PMID:21729777   PMID:21729784   PMID:21873635   PMID:21973168   PMID:21977911   PMID:22210892   PMID:22290437   PMID:22292011  
PMID:22319554   PMID:22322974   PMID:22482732   PMID:22504641   PMID:22570637   PMID:22669107   PMID:22700793   PMID:22711985   PMID:22714890   PMID:22922362   PMID:22937159   PMID:23027941  
PMID:23193188   PMID:23248301   PMID:23307821   PMID:23318224   PMID:23348961   PMID:23433317   PMID:23531880   PMID:23554936   PMID:23575864   PMID:23728800   PMID:23942234   PMID:23973221  
PMID:23979016   PMID:24101522   PMID:24137001   PMID:24325869   PMID:24467246   PMID:24651695   PMID:24675724   PMID:24705708   PMID:24821761   PMID:24982181   PMID:25209548   PMID:25703143  
PMID:25774914   PMID:25775215   PMID:25839654   PMID:25935483   PMID:26159900   PMID:26302788   PMID:26310456   PMID:26329601   PMID:26384464   PMID:26503783   PMID:26584622   PMID:26658965  
PMID:26740329   PMID:26786659   PMID:26843327   PMID:26892542   PMID:27001848   PMID:27143785   PMID:27167731   PMID:27335461   PMID:27448584   PMID:27612612   PMID:27802136   PMID:27824289  
PMID:28125315   PMID:28288100   PMID:28580685   PMID:28682643   PMID:28743993   PMID:28991910   PMID:29080214   PMID:29407374   PMID:29425509   PMID:29500401   PMID:29503092   PMID:29545108  
PMID:29604941   PMID:29664738   PMID:29803672   PMID:30026307   PMID:30038234   PMID:30248537   PMID:30550785   PMID:30951662   PMID:30979776   PMID:31077711   PMID:31084931   PMID:31097699  
PMID:31227579   PMID:31278927   PMID:31495264   PMID:31534017   PMID:31541101   PMID:31629407   PMID:32075915   PMID:32092784   PMID:32098917   PMID:32127556   PMID:32379499   PMID:32555448  
PMID:32628936   PMID:32703236   PMID:32893191   PMID:32916152   PMID:33080340   PMID:33158935   PMID:33235311   PMID:33766932   PMID:34304694   PMID:34556771   PMID:34591784   PMID:34747636  
PMID:34796378   PMID:34806650   PMID:35013139   PMID:35024765   PMID:35099001   PMID:35113157   PMID:35361881   PMID:35425987   PMID:35594378   PMID:35692080   PMID:35693944   PMID:36096645  
PMID:36300569   PMID:36413144   PMID:36471071   PMID:36552718   PMID:36575317   PMID:37044212   PMID:37085894   PMID:37094986   PMID:37158107   PMID:37417428   PMID:37460623   PMID:37532472  
PMID:37858706   PMID:37994046   PMID:38254634   PMID:38493498   PMID:38531064   PMID:38654121   PMID:38956165   PMID:38990722  


Genomics

Comparative Map Data
Yy1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912108,758,841 - 108,786,074 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12108,758,899 - 108,786,074 (+)EnsemblGRCm39 Ensembl
GRCm3812108,792,945 - 108,820,148 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12108,792,973 - 108,820,148 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712110,031,521 - 110,054,842 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612109,241,118 - 109,264,439 (+)NCBIMGSCv36mm8
Celera12110,029,534 - 110,052,930 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1259.58NCBI
YY1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814100,239,144 - 100,282,788 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14100,238,298 - 100,282,788 (+)EnsemblGRCh38hg38GRCh38
GRCh3714100,705,481 - 100,749,125 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361499,774,855 - 99,814,557 (+)NCBINCBI36Build 36hg18NCBI36
Build 341499,774,854 - 99,814,557NCBI
Celera1480,759,739 - 80,799,431 (+)NCBICelera
Cytogenetic Map14q32.2NCBI
HuRef1480,888,079 - 80,926,725 (+)NCBIHuRef
CHM1_114100,642,915 - 100,683,150 (+)NCBICHM1_1
T2T-CHM13v2.01494,472,191 - 94,515,818 (+)NCBIT2T-CHM13v2.0
Yy1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86133,471,615 - 133,500,875 (+)NCBIGRCr8
mRatBN7.26127,706,739 - 127,736,499 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6127,707,596 - 127,732,747 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6127,830,843 - 127,855,090 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06128,125,889 - 128,150,136 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06127,484,792 - 127,509,137 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06132,702,443 - 132,726,848 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6132,702,448 - 132,727,046 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06141,872,505 - 141,896,924 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46133,132,419 - 133,156,686 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16133,138,605 - 133,162,873 (+)NCBI
Celera6125,273,530 - 125,282,803 (+)NCBICelera
Cytogenetic Map6q32NCBI
Yy1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543821,341,374 - 21,377,674 (+)NCBIChiLan1.0ChiLan1.0
YY1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215101,390,655 - 101,434,179 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114100,607,371 - 100,650,673 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01480,859,491 - 80,903,651 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114100,173,287 - 100,217,651 (+)NCBIpanpan1.1PanPan1.1panPan2
YY1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1868,539,511 - 68,572,796 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl868,539,353 - 68,568,058 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha868,058,331 - 68,091,508 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0868,823,410 - 68,856,669 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl868,823,416 - 68,851,926 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1868,485,332 - 68,518,533 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0868,551,498 - 68,584,736 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0868,948,873 - 68,982,099 (+)NCBIUU_Cfam_GSD_1.0
Yy1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086406,137,064 - 6,171,061 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366043,911,407 - 3,945,405 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
YY1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7121,132,191 - 121,170,697 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17121,132,168 - 121,170,699 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27128,602,231 - 128,613,935 (-)NCBISscrofa10.2Sscrofa10.2susScr3
YY1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12478,199,172 - 78,243,081 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2478,199,039 - 78,237,165 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605365,338,296 - 65,383,353 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Yy1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247343,846,765 - 3,875,294 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247343,846,753 - 3,875,294 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Yy1
910 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:333
Count of miRNA genes:223
Interacting mature miRNAs:261
Transcripts:ENSMUST00000021692, ENSMUST00000126912
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
39128213Lwq23_mliver weight QTL 10 (mouse)1280956708113383533Mouse
1300883Ath21_matherosclerosis 21 (mouse)Not determined1285961579119961683Mouse
12910532Nrq10a_mnoise-induced hearing loss resistant QTL 10a (mouse)1292750025120092757Mouse
12910533Nrq10_mnoise-induced hearing loss resistant QTL 10 (mouse)1292750025120092757Mouse
1357463Vtbt14_mvertebral trabecular bone trait 14 (mouse)Not determined1292936097120092757Mouse
1301269Sluc12_msusceptibility to lung cancer 12 (mouse)Not determined1296860337120092757Mouse
4142007Chlq17_mcirculating hormone level QTL 17 (mouse)Not determined1288052874120092757Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
11039526Ccc1_mcolitis susceptibility in the Collaborative Cross 1 (mouse)1293528334111028223Mouse
1300545Lifespan3_mlife span 3 (mouse)Not determined1288052874120092757Mouse
4141610Tailaq1_mtail length adjusted QTL 1 (mouse)Not determined80956708113383533Mouse
1301836Heal5_mwound healing/regeneration 5 (mouse)Not determined1289939031120092757Mouse
13524846Ppiq11_mprepulse inhibition QTL 11 (mouse)1282666396116666396Mouse
10412156Nociq3_mnociceptive sensitivity inflammatory QTL 3 (mouse)Not determined1286396075114831653Mouse
13524842Ppiq10a_mprepulse inhibition QTL 10a (mouse)1277512220111512220Mouse
1301879Insq10_minsulin QTL 10 (mouse)Not determined1283532075117532224Mouse
10402491Dipa4_mdrug induced psychomotor activation 4 (mouse)Not determined1291222515120092757Mouse
1301492Dbsty3_mdiabesity 3 (mouse)Not determined1283532075117532224Mouse
4141335W6q10_mweight 6 weeks QTL 10 (mouse)Not determined80956708113383533Mouse
5491194Mobq3_mmultigenic obesity QTL 3 (mouse)Not determined1289664071120092757Mouse
1302138Im6_mimmunoregulatory 6 (mouse)Not determined1296860337120092757Mouse
1301308Prdt4_mprion disease incubation time 4 (mouse)Not determined1288308354120092757Mouse
1301922Bbaa6_mB.burgdorferi-associated arthritis 6 (mouse)Not determined1290308268120092757Mouse
1302177Dps2_mdelta power in slow-wave sleep 2 (mouse)Not determined1294146064120092757Mouse
10412075Nils1_mneointima lesion size 1 (mouse)Not determined12102024665120092757Mouse
27226793Feml10_mfemur length 10, 5 week (mouse)1268346774113363620Mouse
4142401Egq10_mearly growth QTL 10 (mouse)Not determined80956708113383533Mouse
1300973Abmm_mantibody mediated myocarditis (mouse)Not determined1293264461120092757Mouse
13524849Ppiq11a_mprepulse inhibition QTL 11a (mouse)1280989143114989143Mouse

Markers in Region
RH131280  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812108,792,471 - 108,792,689UniSTSGRCm38
MGSCv3712110,030,681 - 110,030,899UniSTSGRCm37
Celera12110,028,735 - 110,028,953UniSTS
Cytogenetic Map12F1UniSTS
cM Map1253.0UniSTS
Yy1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12F1UniSTS
cM Map1253.0UniSTS
cM Map1253.0UniSTS
D12Mit123  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812108,812,799 - 108,812,936UniSTSGRCm38
MGSCv3712110,051,009 - 110,051,146UniSTSGRCm37
Celera12110,049,099 - 110,049,234UniSTS
Cytogenetic Map12F1UniSTS
cM Map1253.0UniSTS
Whitehead Genetic1250.3UniSTS
D12Mit123.1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812108,812,712 - 108,812,854UniSTSGRCm38
MGSCv3712110,050,922 - 110,051,064UniSTSGRCm37
Celera12110,049,012 - 110,049,154UniSTS
Cytogenetic Map12F1UniSTS
cM Map1253.0UniSTS
cM Map12 UniSTS
Whitehead_YAC12 UniSTS
D12Mit181  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812108,798,859 - 108,798,968UniSTSGRCm38
MGSCv3712110,037,069 - 110,037,178UniSTSGRCm37
Celera12110,035,158 - 110,035,267UniSTS
Cytogenetic Map12F1UniSTS
cM Map1253.0UniSTS
Whitehead Genetic1250.3UniSTS
Whitehead/MRC_RH121023.9UniSTS
Whitehead_YAC12 UniSTS
PMC84716P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812108,793,669 - 108,793,880UniSTSGRCm38
MGSCv3712110,031,879 - 110,032,090UniSTSGRCm37
Celera12110,029,892 - 110,030,103UniSTS
Cytogenetic Map12F1UniSTS
cM Map1253.0UniSTS
G36215  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812108,806,510 - 108,806,605UniSTSGRCm38
MGSCv3712110,044,720 - 110,044,815UniSTSGRCm37
Celera12110,042,810 - 110,042,905UniSTS
Cytogenetic Map12F1UniSTS
cM Map1253.0UniSTS
D12Mit123.2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812108,812,944 - 108,813,060UniSTSGRCm38
MGSCv3712110,051,154 - 110,051,270UniSTSGRCm37
Celera12110,049,242 - 110,049,358UniSTS
Cytogenetic Map12F1UniSTS
cM Map1253.0UniSTS
cM Map12 UniSTS
Yy1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12F1UniSTS
cM Map1253.0UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000021692   ⟹   ENSMUSP00000021692
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12108,758,899 - 108,786,074 (+)Ensembl
GRCm38.p6 Ensembl12108,792,973 - 108,820,148 (+)Ensembl
Ensembl Acc Id: ENSMUST00000126912
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12108,772,165 - 108,781,490 (+)Ensembl
GRCm38.p6 Ensembl12108,806,239 - 108,815,564 (+)Ensembl
RefSeq Acc Id: NM_009537   ⟹   NP_033563
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912108,759,223 - 108,786,074 (+)NCBI
GRCm3812108,793,297 - 108,820,148 (+)NCBI
MGSCv3712110,031,521 - 110,054,842 (+)RGD
Celera12110,029,534 - 110,052,930 (+)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036157387   ⟹   XP_036013280
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912108,758,841 - 108,786,074 (+)NCBI
Sequence:
RefSeq Acc Id: XR_004937493
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912108,758,841 - 108,782,558 (+)NCBI
Sequence:
RefSeq Acc Id: NP_033563   ⟸   NM_009537
- UniProtKB: Q00899 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000021692   ⟸   ENSMUST00000021692
RefSeq Acc Id: XP_036013280   ⟸   XM_036157387
- Peptide Label: isoform X1
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q00899-F1-model_v2 AlphaFold Q00899 1-414 view protein structure

Promoters
RGD ID:8679214
Promoter ID:EPDNEW_M17638
Type:initiation region
Name:Yy1_1
Description:Mus musculus YY1 transcription factor , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3812108,793,297 - 108,793,357EPDNEW
RGD ID:6823517
Promoter ID:MM_KWN:12700
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000084993,   OTTMUST00000041760
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3612110,030,521 - 110,032,177 (+)MPROMDB
RGD ID:6823519
Promoter ID:MM_KWN:12701
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000041761
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3612110,043,816 - 110,044,316 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99150 AgrOrtholog
Ensembl Genes ENSMUSG00000021264 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000021692 ENTREZGENE
  ENSMUST00000021692.9 UniProtKB/Swiss-Prot
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro YY-1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22632 UniProtKB/Swiss-Prot
MGD MGI:99150 ENTREZGENE
NCBI Gene 22632 ENTREZGENE
PANTHER TRANSCRIPTION FACTOR YY1-RELATED UniProtKB/TrEMBL
  TRANSCRIPTIONAL REPRESSOR PROTEIN YY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSCRIPTIONAL REPRESSOR PROTEIN YY1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB YY1 RGD
PhenoGen Yy1 PhenoGen
PIRSF TF_Yin_yang UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q00899 ENTREZGENE
  Q3TLF0_MOUSE UniProtKB/TrEMBL
  Q8C6B5_MOUSE UniProtKB/TrEMBL
  TYY1_MOUSE UniProtKB/Swiss-Prot