Xrcc5 (X-ray repair complementing defective repair in Chinese hamster cells 5) - Rat Genome Database

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Gene: Xrcc5 (X-ray repair complementing defective repair in Chinese hamster cells 5) Mus musculus
Analyze
Symbol: Xrcc5
Name: X-ray repair complementing defective repair in Chinese hamster cells 5
RGD ID: 11495
MGI Page MGI
Description: Predicted to enable several functions, including ATP hydrolysis activity; nucleic acid binding activity; and ubiquitin protein ligase binding activity. Predicted to contribute to 5'-deoxyribose-5-phosphate lyase activity; DNA end binding activity; and double-stranded telomeric DNA binding activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; hemopoiesis; and positive regulation of neurogenesis. Located in cytoplasm and nucleus. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; multiple myeloma; and rectum cancer. Orthologous to human XRCC5 (X-ray repair cross complementing 5).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI314015; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair protein XRCC5; ku autoantigen protein p86 homolog; Ku p80; Ku80; Ku86; nuclear factor IV; X-ray repair cross-complementing protein 5
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39172,346,576 - 72,434,112 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl172,346,586 - 72,434,111 (+)EnsemblGRCm39 Ensembl
GRCm38172,307,417 - 72,394,953 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl172,307,427 - 72,394,952 (+)EnsemblGRCm38mm10GRCm38
MGSCv37172,353,995 - 72,441,527 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36172,240,728 - 72,328,156 (+)NCBIMGSCv36mm8
Celera172,875,673 - 72,963,703 (+)NCBICelera
Cytogenetic Map1C3NCBI
cM Map136.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(-)-quinic acid  (ISO)
(S)-naringenin  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2'-dithiodiethanol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,6-dinitrotoluene  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-1,8-naphthalimide  (EXP)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
biphenyl-4-amine  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
cisplatin  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (ISO)
curcumin  (ISO)
cyproconazole  (ISO)
D-glucose  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
disodium selenite  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenofibrate  (ISO)
finasteride  (ISO)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (ISO)
glucose  (ISO)
hydrogen peroxide  (ISO)
hydroxyurea  (EXP)
irinotecan  (ISO)
ivermectin  (ISO)
methotrexate  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nitrogen mustard  (ISO)
ozone  (EXP)
p-anisidine  (EXP)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenethyl caffeate  (ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
prochloraz  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
sodium fluoride  (EXP)
sulindac  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell differentiation  (IAGP)
abnormal bone marrow cell morphology/development  (IAGP)
abnormal CD8-positive, alpha-beta T cell differentiation  (IEA)
abnormal class switch recombination  (IAGP)
abnormal double-strand DNA break repair  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal lymphocyte morphology  (IAGP)
abnormal maternal nurturing  (IAGP)
abnormal retina morphology  (IAGP)
abnormal small intestine morphology  (IAGP)
abnormal T cell differentiation  (IEA)
absent T cells  (IAGP)
arrested B cell differentiation  (IAGP)
arrested T cell differentiation  (IAGP)
athymia  (IAGP)
chromosome breakage  (IAGP)
decreased B-2 B cell number  (IEA)
decreased body size  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IEA)
decreased CD8-positive, alpha-beta T cell number  (IEA)
decreased CD8-positive, naive alpha-beta T cell number  (IEA)
decreased litter size  (IAGP)
decreased T cell number  (IEA)
dehydration  (IAGP)
fetal growth retardation  (IAGP)
impaired balance  (IAGP)
increased B-1a cell number  (IEA)
increased B-1b cell number  (IEA)
increased CD4-positive, alpha-beta T cell number  (IEA)
increased cellular sensitivity to ionizing radiation  (IAGP)
increased cerebellar granule cell number  (IAGP)
increased dendritic cell number  (IEA)
increased double-negative T cell number  (IAGP)
increased effector memory CD4-positive, alpha-beta T cell number  (IEA)
increased effector memory CD8-positive, alpha-beta T cell number  (IEA)
increased lymphoma incidence  (IAGP)
increased medulloblastoma incidence  (IAGP)
increased neuron apoptosis  (IAGP)
increased neutrophil cell number  (IEA)
increased retina apoptosis  (IAGP)
increased sarcoma incidence  (IAGP)
increased stomach tumor incidence  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
lymph node hypoplasia  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
proportional dwarf  (IAGP)
respiratory distress  (IAGP)
small spleen  (IAGP)
spleen hypoplasia  (IAGP)
thymus hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice. Barnes DE, etal., Curr Biol 1998 Dec 17-31;8(25):1395-8.
2. Transcriptional regulation of P450scc gene expression in the embryonic rodent nervous system. Hammer F, etal., Endocrinology 2004 Feb;145(2):901-12. Epub 2003 Oct 23.
3. Variation in DNA repair genes XRCC3, XRCC4, XRCC5 and susceptibility to myeloma. Hayden PJ, etal., Hum Mol Genet. 2007 Dec 15;16(24):3117-27. Epub 2007 Sep 26.
4. Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene. Hersh CP, etal., Am J Respir Crit Care Med. 2010 Sep 1;182(5):605-13. doi: 10.1164/rccm.200910-1586OC. Epub 2010 May 12.
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Lieber MR Annu Rev Biochem. 2010;79:181-211. doi: 10.1146/annurev.biochem.052308.093131.
7. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. Double-strand break repair and colorectal cancer: gene variants within 3' UTRs and microRNAs binding as modulators of cancer risk and clinical outcome. Naccarati A, etal., Oncotarget. 2016 Apr 26;7(17):23156-69. doi: 10.18632/oncotarget.6804.
10. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
11. Expression and heterodimer-binding activity of Ku70 and Ku80 in human non-melanoma skin cancer. Parrella P, etal., J Clin Pathol. 2006 Nov;59(11):1181-5. Epub 2006 Feb 23.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1505945   PMID:1641347   PMID:1701785   PMID:8632777   PMID:8700231   PMID:8756720   PMID:8943369   PMID:8954777   PMID:9252118   PMID:9294146   PMID:9362500   PMID:9391070  
PMID:9545251   PMID:9990036   PMID:10190491   PMID:10207111   PMID:10349636   PMID:10441505   PMID:10485901   PMID:10576891   PMID:10607596   PMID:10716994   PMID:10761921   PMID:10805721  
PMID:10922068   PMID:11042159   PMID:11076861   PMID:11248063   PMID:11256607   PMID:11340158   PMID:11438738   PMID:11516951   PMID:11751629   PMID:11980718   PMID:12119352   PMID:12186839  
PMID:12460917   PMID:12477932   PMID:12520002   PMID:12531011   PMID:12531386   PMID:12604618   PMID:12810694   PMID:12846809   PMID:12904583   PMID:12943919   PMID:14610273   PMID:14642570  
PMID:14706343   PMID:14988733   PMID:15175261   PMID:15351736   PMID:15371510   PMID:15520243   PMID:15545322   PMID:15782199   PMID:15860505   PMID:15870260   PMID:16014376   PMID:16027367  
PMID:16141072   PMID:16141073   PMID:16400328   PMID:16465594   PMID:16751807   PMID:16797606   PMID:16916625   PMID:17010969   PMID:17272272   PMID:17296600   PMID:17554309   PMID:17671430  
PMID:17875923   PMID:17928034   PMID:18093953   PMID:18325854   PMID:18332040   PMID:18501428   PMID:18653525   PMID:18799693   PMID:18941635   PMID:19010925   PMID:19057578   PMID:19079133  
PMID:19181665   PMID:19330025   PMID:19597334   PMID:19794960   PMID:19946467   PMID:20133803   PMID:20142431   PMID:20145501   PMID:20362541   PMID:20362542   PMID:20439489   PMID:20498273  
PMID:20567092   PMID:20966962   PMID:21267068   PMID:21663524   PMID:21873635   PMID:22265216   PMID:22445450   PMID:22445484   PMID:22556254   PMID:22915554   PMID:23375831   PMID:23426265  
PMID:23567907   PMID:23685356   PMID:23897892   PMID:24466051   PMID:24569637   PMID:24740260   PMID:24842372   PMID:25082302   PMID:25818648   PMID:25916111   PMID:26206133   PMID:26590968  
PMID:26833222   PMID:27746211   PMID:27798842   PMID:28671696   PMID:30017584   PMID:30188106   PMID:30196744   PMID:30579708   PMID:30595499   PMID:32098917   PMID:32325033   PMID:32937838  
PMID:33372229   PMID:33979621   PMID:35012549   PMID:35737378   PMID:35910805  


Genomics

Comparative Map Data
Xrcc5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39172,346,576 - 72,434,112 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl172,346,586 - 72,434,111 (+)EnsemblGRCm39 Ensembl
GRCm38172,307,417 - 72,394,953 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl172,307,427 - 72,394,952 (+)EnsemblGRCm38mm10GRCm38
MGSCv37172,353,995 - 72,441,527 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36172,240,728 - 72,328,156 (+)NCBIMGSCv36mm8
Celera172,875,673 - 72,963,703 (+)NCBICelera
Cytogenetic Map1C3NCBI
cM Map136.5NCBI
XRCC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382216,109,348 - 216,206,293 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2216,107,464 - 216,206,303 (+)EnsemblGRCh38hg38GRCh38
GRCh372216,974,071 - 217,071,016 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362216,682,378 - 216,779,248 (+)NCBINCBI36Build 36hg18NCBI36
Build 342216,799,637 - 216,896,509NCBI
Celera2210,743,609 - 210,840,560 (+)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2208,830,614 - 208,927,713 (+)NCBIHuRef
CHM1_12216,979,976 - 217,076,949 (+)NCBICHM1_1
T2T-CHM13v2.02216,594,753 - 216,691,715 (+)NCBIT2T-CHM13v2.0
Xrcc5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2973,955,220 - 74,044,020 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl973,955,216 - 74,044,018 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx982,419,375 - 82,508,055 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0987,548,243 - 87,636,932 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0985,935,851 - 86,024,584 (+)NCBIRnor_WKY
Rnor_6.0979,659,275 - 79,748,050 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl979,659,251 - 79,748,078 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0979,432,205 - 79,520,611 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4971,472,459 - 71,581,936 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1971,619,440 - 71,728,918 (+)NCBI
Celera971,352,925 - 71,440,328 (+)NCBICelera
Cytogenetic Map9q33NCBI
Xrcc5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545316,967,453 - 17,054,634 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545316,967,453 - 17,054,634 (-)NCBIChiLan1.0ChiLan1.0
XRCC5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B221,972,607 - 222,072,318 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B221,972,742 - 222,071,235 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B103,371,459 - 103,468,419 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
XRCC5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13723,095,769 - 23,185,680 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3723,095,754 - 23,185,586 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3723,923,245 - 24,015,080 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03723,120,975 - 23,212,731 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3723,120,932 - 23,212,731 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13723,007,952 - 23,098,174 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03722,960,108 - 23,051,031 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03722,977,769 - 23,068,341 (+)NCBIUU_Cfam_GSD_1.0
Xrcc5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303171,487,889 - 171,588,600 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365861,055,335 - 1,137,984 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365861,055,478 - 1,137,924 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
XRCC5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15118,354,796 - 118,451,960 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115118,354,943 - 118,451,974 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215131,235,804 - 131,332,992 (+)NCBISscrofa10.2Sscrofa10.2susScr3
XRCC5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110101,952,909 - 102,051,059 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10101,953,067 - 102,049,964 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604097,347,634 - 97,445,372 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:116
Count of miRNA genes:109
Interacting mature miRNAs:116
Transcripts:ENSMUST00000027379
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1357475w3q13_mweight 3 weeks QTL 13 (mouse)Not determined12310959173976915Mouse
1357824Estoq4_membryo survival total QTL 4 (mouse)Not determined13476013873976915Mouse
39128207Lwq16_mliver weight QTL 16 (mouse)13476013873976915Mouse
1357759W3q12_mweight 3 weeks QTL 12 (mouse)Not determined13476013873976915Mouse
1357651Lgq5_mlate growth QTL 5 (mouse)Not determined13476013873976915Mouse
1357506W10q6_mweight 10 weeks QTL 6 (mouse)Not determined13476013873976915Mouse
1357524W6q14_mweight 6 weeks QTL 14 (mouse)Not determined13476013873976915Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
1301954Lrnx11_mlearning-contextual 11 (mouse)Not determined13913280874516365Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
1301166Thypr2_mthymocyte proliferative response 2 (mouse)Not determined14127312475273271Mouse
18182931Metl1_mmetabolite locus 1, pyridoxate (mouse)14127539975275399Mouse
4141032Wbcc1_mwhite blood cell count 1 (mouse)Not determined4225966776259667Mouse
1301714Vertcling_mvertical clinging (mouse)Not determined14293803176938167Mouse
1558855Eae30_mexperimental allergic encephalomyelitis susceptibility 30 (mouse)Not determined14541777372975057Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
1301670Ssta1_msusceptibility to Salmonella typhimurium antigens 1 (mouse)Not determined14594675579946882Mouse
1301616Yaa2_mY-linked autoimmune acceleration 2 (mouse)Not determined14685469080854839Mouse
1301225Sle7_msystematic lupus erythematosus susceptibility 7 (mouse)Not determined14685469080854839Mouse
1558905Gct7_mgranulosa cell tumorigenesis 7 (mouse)Not determined14734989481350013Mouse
1558822Vas1_mautoimmune vasitis resistance 1 (mouse)Not determined14888900682889210Mouse
1301211Bbaa11_mB.burgdorferi-associated arthritis 11 (mouse)Not determined14888900682889210Mouse
1301430Cdcs2_mcytokine deficiency colitis susceptibility 2 (mouse)Not determined14889234582892485Mouse
10043965Obq24_mobesity QTL 24 (mouse)Not determined15089021684890216Mouse
4141305Tgq9_mtriglyceride QTL 9 (mouse)Not determined5142160585421605Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
1357741Nidd5k_mNidd5 on KK-A<y> (mouse)Not determined15597494889975057Mouse
4142467Wbcq1_mwhite blood cell quantitative locus 1 (mouse)Not determined15626621490266360Mouse
1357505Vtbt1_mvertebral trabecular bone trait 1 (mouse)Not determined15626621490266360Mouse
1558717Ses1a_msalmonella enteritidis susceptibility 1a (mouse)Not determined15672692290727077Mouse
1301933Insq6_minsulin QTL 6 (mouse)Not determined15672692290727077Mouse
14746998Mancz1_mmandible centroid size 1 (mouse)15794135191941351Mouse
14747009Manh49_mmandible shape 49 (mouse)15794135191941351Mouse
1300746Skl1_mskeletal size (tail length) 1 (mouse)Not determined15799197791992080Mouse
1357679Egrm1_mearly growth rate, maternal effect 1 (mouse)Not determined15799197791992080Mouse
1301162Skull1_mskull morphology 1 (mouse)Not determined15799197791992080Mouse
1301667Lxw5_mlupus BXSB x NZW 5 (mouse)Not determined15854919192549443Mouse
1301444Alcw5_malcohol withdrawal 5 (mouse)Not determined15854919192549443Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162946755120529678Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
1302119Cia15_mcollagen induced arthritis 15 (mouse)Not determined16588900688496101Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167339159129727737Mouse
4141625Emo4_memotionality 4 (mouse)Not determined6807134586235027Mouse
1302146Cocrb1_mcocaine related behavior 1 (mouse)Not determined170133533104139557Mouse
4141393Mol2_mmodifier of LPS-response 2 (mouse)Not determined7162467978183144Mouse
13513915Heal50_mwound healing/ regeneration 50 (mouse)17166888073403586Mouse

Markers in Region
AI314015  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38172,394,720 - 72,394,831UniSTSGRCm38
MGSCv37172,441,294 - 72,441,405UniSTSGRCm37
Celera172,963,470 - 72,963,581UniSTS
Cytogenetic Map1EUniSTS
cM Map142.0UniSTS
Whitehead/MRC_RH1997.13UniSTS
RH118241  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38172,369,048 - 72,369,207UniSTSGRCm38
MGSCv37172,415,622 - 72,415,781UniSTSGRCm37
Celera172,937,540 - 72,937,699UniSTS
Cytogenetic Map1EUniSTS
cM Map142.0UniSTS
Whitehead/MRC_RH1995.93UniSTS
PMC17958P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38172,325,075 - 72,325,402UniSTSGRCm38
MGSCv37172,371,649 - 72,371,976UniSTSGRCm37
Celera172,893,569 - 72,893,896UniSTS
Cytogenetic Map1EUniSTS
cM Map142.0UniSTS
Xrcc5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1EUniSTS
cM Map142.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001357519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001357520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006495892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006495893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC114629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC114905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF166486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK084263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ220465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U68181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X66323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000027379   ⟹   ENSMUSP00000027379
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl172,346,586 - 72,434,111 (+)Ensembl
GRCm38.p6 Ensembl172,307,427 - 72,394,952 (+)Ensembl
RefSeq Acc Id: NM_001357519   ⟹   NP_001344448
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39172,346,580 - 72,434,112 (+)NCBI
GRCm38172,307,421 - 72,394,953 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001357520   ⟹   NP_001344449
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39172,346,580 - 72,434,112 (+)NCBI
GRCm38172,307,421 - 72,394,953 (+)NCBI
Sequence:
RefSeq Acc Id: NM_009533   ⟹   NP_033559
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39172,346,580 - 72,434,112 (+)NCBI
GRCm38172,307,421 - 72,394,953 (+)NCBI
MGSCv37172,353,995 - 72,441,527 (+)RGD
Celera172,875,673 - 72,963,703 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006495892   ⟹   XP_006495955
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39172,346,576 - 72,434,112 (+)NCBI
GRCm38172,307,417 - 72,394,953 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006495893   ⟹   XP_006495956
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39172,346,576 - 72,434,101 (+)NCBI
GRCm38172,307,417 - 72,394,942 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033559   ⟸   NM_009533
- Peptide Label: isoform 1
- UniProtKB: Q9R169 (UniProtKB/Swiss-Prot),   P27641 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006495955   ⟸   XM_006495892
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006495956   ⟸   XM_006495893
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001344448   ⟸   NM_001357519
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001344449   ⟸   NM_001357520
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000027379   ⟸   ENSMUST00000027379
Protein Domains
Ku   Ku70/Ku80 N-terminal alpha/beta

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P27641-F1-model_v2 AlphaFold P27641 1-732 view protein structure

Promoters
RGD ID:6874020
Promoter ID:EPDNEW_M461
Type:initiation region
Name:Xrcc5_1
Description:Mus musculus X-ray repair complementing defective repair in Chinesehamster cells 5 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M462  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38172,307,427 - 72,307,487EPDNEW
RGD ID:6874022
Promoter ID:EPDNEW_M462
Type:multiple initiation site
Name:Xrcc5_2
Description:Mus musculus X-ray repair complementing defective repair in Chinesehamster cells 5 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M461  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38172,307,528 - 72,307,588EPDNEW
RGD ID:6818721
Promoter ID:MM_KWN:1119
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   Brain,   ES_Cell,   Kidney,   Liver,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_009533
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36172,353,774 - 72,354,274 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104517 AgrOrtholog
Ensembl Genes ENSMUSG00000026187 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000027379 ENTREZGENE
  ENSMUSP00000027379.9 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000027379 ENTREZGENE
  ENSMUST00000027379.10 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1600.10 UniProtKB/Swiss-Prot
  1.25.40.240 UniProtKB/Swiss-Prot
  2.40.290.10 UniProtKB/Swiss-Prot
  3.40.50.410 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ku70/Ku80_beta-barrel_dom UniProtKB/Swiss-Prot
  Ku80 UniProtKB/Swiss-Prot
  Ku_C UniProtKB/Swiss-Prot
  Ku_C_sf UniProtKB/Swiss-Prot
  Ku_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ku_PK_bind UniProtKB/Swiss-Prot
  SPOC-like_C_dom_sf UniProtKB/Swiss-Prot
  vWFA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22596 UniProtKB/Swiss-Prot
MGD MGI:104517 ENTREZGENE
NCBI Gene 22596 ENTREZGENE
PANTHER KU AUTOANTIGEN DNA HELICASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ku_C UniProtKB/Swiss-Prot
  Ku_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ku_PK_bind UniProtKB/Swiss-Prot
  PF02735 UniProtKB/Swiss-Prot
PharmGKB XRCC5 RGD
PhenoGen Xrcc5 PhenoGen
PIRSF Ku80 UniProtKB/Swiss-Prot
SMART Ku78 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF100939 UniProtKB/Swiss-Prot
  SSF101420 UniProtKB/Swiss-Prot
  SSF53300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P27641 ENTREZGENE
  Q9CRI5_MOUSE UniProtKB/TrEMBL
  Q9R169 ENTREZGENE
  XRCC5_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q3TE46 UniProtKB/Swiss-Prot
  Q3TJT0 UniProtKB/Swiss-Prot
  Q3TN82 UniProtKB/Swiss-Prot
  Q80UT1 UniProtKB/Swiss-Prot
  Q8C4N6 UniProtKB/Swiss-Prot
  Q8K1K7 UniProtKB/Swiss-Prot
  Q9R169 UniProtKB/Swiss-Prot