Wt1 (WT1 transcription factor) - Rat Genome Database

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Gene: Wt1 (WT1 transcription factor) Mus musculus
Analyze
Symbol: Wt1
Name: WT1 transcription factor
RGD ID: 11493
MGI Page MGI
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and double-stranded DNA binding activity. Involved in several processes, including kidney development; regulation of DNA-templated transcription; and reproductive structure development. Acts upstream of or within several processes, including male gonad development; negative regulation of mesenchymal cell apoptotic process involved in metanephros development; and vasculogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; body cavity or lining; central nervous system; genitourinary system; and heart. Used to study Denys-Drash syndrome and congenital diaphragmatic hernia. Human ortholog(s) of this gene implicated in several diseases, including Denys-Drash syndrome; Frasier syndrome; malignant mesothelioma; nephroblastoma (multiple); and nephrotic syndrome type 4. Orthologous to human WT1 (WT1 transcription factor).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: D630046I19Rik; Wilms tumor 1 homolog; Wilms tumor homolog; Wilms tumor protein homolog; Wt-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392104,956,874 - 105,003,959 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2104,956,874 - 105,003,961 (+)EnsemblGRCm39 Ensembl
GRCm382105,126,529 - 105,173,614 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2105,126,529 - 105,173,616 (+)EnsemblGRCm38mm10GRCm38
MGSCv372104,966,686 - 105,013,771 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362104,927,368 - 104,974,451 (+)NCBIMGSCv36mm8
Celera2106,361,212 - 106,408,919 (+)NCBICelera
Cytogenetic Map2E3NCBI
cM Map255.06NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
acute promyelocytic leukemia  (ISO)
Alzheimer's disease  (ISO)
aniridia  (ISO)
aniridia 1  (ISO)
atypical hemolytic-uremic syndrome  (ISO)
B-cell acute lymphoblastic leukemia  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
B-lymphoblastic leukemia/lymphoma MLL rearranged  (ISO)
benign familial hematuria  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Chromosome 11p Deletion Syndrome  (ISO)
chronic kidney disease  (ISO)
chronic myeloid leukemia  (ISO)
Colonic Neoplasms  (ISO)
congenital diaphragmatic hernia  (IAGP,ISO)
Denys-Drash syndrome  (IAGP,ISO)
Diaphragmatic Hernia  (ISO)
Diffuse Mesangial Sclerosis  (ISO)
disorder of sexual development  (ISO)
endometrial cancer  (ISO)
focal segmental glomerulosclerosis  (ISO)
Frasier syndrome  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
glomerulonephritis  (ISO)
gonadal dysgenesis  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
intellectual disability  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (IEP)
leukemia  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
Male Genital Neoplasms  (ISO)
malignant mesothelioma  (ISO)
Meacham Winn Culler Syndrome  (ISO)
Mesothelioma  (ISO)
nephroblastoma  (ISO)
nephrotic syndrome  (ISO)
nephrotic syndrome type 1  (ISO)
nephrotic syndrome type 2  (ISO)
nephrotic syndrome type 4  (ISO)
neurilemmoma  (ISO)
osteosarcoma  (ISO)
ovarian cancer  (ISO)
ovarian serous carcinoma  (ISO)
pancreatic cancer  (ISO)
Peritoneal Neoplasms  (ISO)
primary ovarian insufficiency  (ISO)
proteinuria  (ISO)
renal Wilms' tumor  (ISO)
spermatogenic failure 57  (ISO)
WAGR syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-naringenin  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-ethoxyethanol  (ISO)
2-methoxyethanol  (ISO)
3,7-dihydropurine-6-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (EXP)
acetic acid  (EXP)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (ISO)
ammonium chloride  (ISO)
amphibole asbestos  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
bromochloroacetic acid  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP)
caffeine  (ISO)
cannabidiol  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
carmustine  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chrysene  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
crocidolite asbestos  (EXP)
curcumin  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
dapagliflozin  (ISO)
demethoxycurcumin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dieldrin  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
diuron  (ISO)
ergosta-4,6,8(14),22-tetraen-3-one  (EXP)
ethanol  (ISO)
fenvalerate  (ISO)
flavonoids  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (ISO)
genistein  (ISO)
gentamycin  (ISO)
Indeno[1,2,3-cd]pyrene  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
losartan  (EXP)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercaptopurine  (ISO)
methapyrilene  (ISO)
nickel subsulfide  (EXP)
nitric oxide  (ISO)
nitrofen  (ISO)
Pachymic acid  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (EXP)
perfluorononanoic acid  (ISO)
potassium dichromate  (EXP)
progesterone  (ISO)
prostaglandin E2  (ISO)
purine-6-thiol  (ISO)
pyrethrins  (ISO)
quercetin  (ISO)
resmethrin  (EXP)
resveratrol  (ISO)
rosuvastatin calcium  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
spironolactone  (ISO)
staurosporine  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenylstannane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
zearalenone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal cortex formation  (IMP)
adrenal gland development  (IMP,ISO)
apoptotic process  (IMP)
branching involved in ureteric bud morphogenesis  (IMP,ISO)
camera-type eye development  (IMP)
cardiac muscle cell fate commitment  (IMP)
cellular response to cAMP  (ISO)
cellular response to gonadotropin stimulus  (ISO,ISS)
coronary vasculature development  (TAS)
diaphragm development  (IMP)
epithelial cell differentiation  (IMP)
flagellated sperm motility  (IMP)
germ cell development  (IMP)
glomerular basement membrane development  (ISO)
glomerulus development  (IMP,ISO)
gonad development  (IMP)
heart development  (IMP,ISO)
kidney development  (IMP,ISO)
male genitalia development  (IMP)
male gonad development  (IGI,IMP,ISO)
mesenchymal cell apoptotic process involved in metanephros development  (IMP)
mesenchymal to epithelial transition  (IMP)
mesonephros development  (IMP)
metanephric comma-shaped body morphogenesis  (IEP)
metanephric epithelium development  (ISO)
metanephric mesenchyme development  (IMP)
metanephric S-shaped body morphogenesis  (IEP,IMP,ISO)
metanephros development  (IMP)
negative regulation of apoptotic process  (IBA,IMP,ISO)
negative regulation of cell growth  (ISO,ISS)
negative regulation of cell population proliferation  (IBA,ISO)
negative regulation of DNA-templated transcription  (IDA,ISO,ISS)
negative regulation of female gonad development  (IMP)
negative regulation of gene expression via chromosomal CpG island methylation  (ISO)
negative regulation of mesenchymal cell apoptotic process involved in metanephros development  (IMP)
negative regulation of metanephric glomerular mesangial cell proliferation  (IMP)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of translation  (ISO,ISS)
podocyte development  (IEP)
podocyte differentiation  (IDA)
positive regulation of apoptotic process  (ISO,ISS)
positive regulation of DNA-templated transcription  (IDA,IMP,ISO,ISS)
positive regulation of gene expression  (ISO)
positive regulation of heart growth  (IMP)
positive regulation of male gonad development  (IMP)
positive regulation of metanephric ureteric bud development  (IMP)
positive regulation of miRNA transcription  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
posterior mesonephric tubule development  (IMP)
regulation of animal organ formation  (IMP)
regulation of DNA-templated transcription  (IDA)
regulation of gene expression  (IMP)
regulation of transcription by RNA polymerase II  (IBA,IDA)
RNA splicing  (IDA)
seminiferous tubule development  (IMP)
Sertoli cell development  (IMP)
sex determination  (IMP,ISO)
single fertilization  (IMP)
spermatogenesis  (IMP)
thorax and anterior abdomen determination  (IMP)
ureteric bud development  (IMP)
vasculogenesis  (IMP)
visceral serous pericardium development  (IMP,ISO,TAS)

Cellular Component
cytoplasm  (IDA)
cytosol  (ISO)
nuclear speck  (ISO,ISS,TAS)
nucleolus  (IEA)
nucleoplasm  (ISO,ISS,TAS)
nucleus  (IDA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adrenal gland development  (IAGP)
abnormal atrioventricular cushion morphology  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal coronary vessel morphology  (IAGP)
abnormal diaphragm development  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal epicardium development  (IAGP)
abnormal glomerular capillary morphology  (IAGP)
abnormal glomerular capsule parietal layer morphology  (IAGP)
abnormal gonadal ridge morphology  (IAGP)
abnormal granulosa cell morphology  (IAGP)
abnormal heart apex morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart right ventricle morphology  (IAGP)
abnormal heart shape  (IAGP)
abnormal intermediate mesoderm morphology  (IAGP)
abnormal kidney calyx morphology  (IAGP)
abnormal kidney collecting duct morphology  (IAGP)
abnormal kidney development  (IAGP)
abnormal kidney interlobular artery morphology  (IAGP)
abnormal kidney mesenchyme morphology  (IAGP)
abnormal kidney vasculature morphology  (IAGP)
abnormal Leydig cell morphology  (IAGP)
abnormal liver development  (IAGP)
abnormal lung development  (IAGP)
abnormal male reproductive system morphology  (IAGP)
abnormal mesangial cell morphology  (IAGP)
abnormal mesenchyme morphology  (IAGP)
abnormal pleural cavity morphology  (IAGP)
abnormal pleuropericardial membrane morphology  (IAGP)
abnormal podocyte morphology  (IAGP)
abnormal primary ovarian follicle morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal reproductive system physiology  (IAGP)
abnormal secondary sex determination  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal Sertoli cell development  (IAGP)
abnormal spleen development  (IAGP)
abnormal testis morphology  (IAGP)
absent adrenal gland  (IAGP)
absent kidney  (IAGP)
absent metanephros  (IAGP)
absent ovary  (IAGP)
absent podocyte foot process  (IAGP)
absent spleen  (IAGP)
absent testes  (IAGP)
agonadal  (IAGP)
albuminuria  (IAGP)
azoospermia  (IAGP)
decreased embryo size  (IAGP)
decreased germ cell number  (IAGP)
decreased glomerular capsule space  (IAGP)
decreased nephron number  (IAGP)
decreased ovulation rate  (IAGP)
decreased renal glomerulus number  (IAGP)
decreased superovulation rate  (IAGP)
delayed kidney development  (IAGP)
diaphragmatic hernia  (IAGP)
dilated renal tubule  (IAGP)
edema  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
expanded mesangial matrix  (IAGP)
glomerular crescent  (IAGP)
glomerulonephritis  (IAGP)
glomerulosclerosis  (IAGP)
hemopericardium  (IAGP)
impaired granulosa cell differentiation  (IAGP)
impaired ovarian folliculogenesis  (IAGP)
increased kidney apoptosis  (IAGP)
increased kidney tumor incidence  (IAGP)
increased mesangial cell number  (IAGP)
increased metanephric mesenchyme apoptosis  (IAGP)
increased renal glomerulus basement membrane thickness  (IAGP)
increased splenocyte apoptosis  (IAGP)
increased urine protein level  (IAGP)
juxtaglomerular cell hyperplasia  (IAGP)
kidney cortex cyst  (IAGP)
kidney cyst  (IAGP)
kidney failure  (IAGP)
kidney medulla hypoplasia  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
liver hypoplasia  (IAGP)
male infertility  (IAGP)
mesangiolysis  (IAGP)
myocardium hypoplasia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
podocyte foot process effacement  (IAGP)
podocyte hypertrophy  (IAGP)
podocyte microvillus transformation  (IAGP)
poor circulation  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
primary atelectasis  (IAGP)
primary sex reversal  (IAGP)
pulmonary hypoplasia  (IAGP)
reduced female fertility  (IAGP)
renal cast  (IAGP)
renal interstitial fibrosis  (IAGP)
small heart  (IAGP)
small kidney  (IAGP)
small ovary  (IAGP)
small testis  (IAGP)
streak gonad  (IAGP)
thin myocardium compact layer  (IAGP)
thin ventricle myocardium compact layer  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
2. Pathologically decreased expression of miR-193a contributes to metastasis by targeting WT1-E-cadherin axis in non-small cell lung cancers. Chen J, etal., J Exp Clin Cancer Res. 2016 Nov 7;35(1):173. doi: 10.1186/s13046-016-0450-8.
3. Homozygous somatic Wt1 point mutations in sporadic unilateral Wilms tumor. Coppes MJ, etal., Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1416-9.
4. A necropsy case of Denys-Drash syndrome with a WT1 mutation in exon 7. Fukuzawa R, etal., J Med Genet. 2002 Aug;39(8):e48.
5. Expression of the 11p13 Wilms' tumor gene, WT1, correlates with histologic category of Wilms' tumor. Gerald WL, etal., Am J Pathol. 1992 May;140(5):1031-7.
6. Combination of MUC5ac and WT-1 immunohistochemistry is useful in distinguishing pancreatic ductal carcinoma from ovarian serous carcinoma in effusion cytology. Han L, etal., Diagn Cytopathol. 2009 Oct 23.
7. Dual usages of single Wilms' tumor 1 immunohistochemistry in evaluation of breast tumors: a preliminary study of 30 cases. Li JH and Man YG, Cancer Biomark. 2009;5(3):109-16.
8. Wilms' tumor suppressor (WT1) is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer's disease. Lovell MA, etal., Brain Res. 2003 Sep 5;983(1-2):84-96.
9. Accumulation of malignant renal stem cells is associated with epigenetic changes in normal renal progenitor genes. Metsuyanim S, etal., Stem Cells. 2008 Jul;26(7):1808-17. doi: 10.1634/stemcells.2007-0322. Epub 2008 May 8.
10. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
11. MGDs mouse GO annotations MGD data from the GO Consortium
12. MGD IEA MGD IEA
13. Immunohistochemical detection of WT1 protein in endometrial cancer. Ohno S, etal., Anticancer Res. 2009 May;29(5):1691-5.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. Mouse MP Annotation Import Pipeline RGD automated import pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Therapeutic potential of human induced pluripotent stem cells and renal progenitor cells in experimental chronic kidney disease. Ribeiro PC, etal., Stem Cell Res Ther. 2020 Dec 9;11(1):530. doi: 10.1186/s13287-020-02060-4.
19. Adenomatoid tumors of the female and male genital tracts: a clinicopathological and immunohistochemical study of 44 cases. Sangoi AR, etal., Mod Pathol. 2009 Sep;22(9):1228-35. Epub 2009 Jun 19.
Additional References at PubMed
PMID:1489725   PMID:1651275   PMID:1655284   PMID:1671709   PMID:1684639   PMID:1797234   PMID:2173141   PMID:7478606   PMID:7585606   PMID:7590255   PMID:7609158   PMID:7651738  
PMID:7700638   PMID:7720589   PMID:7736591   PMID:7805288   PMID:7862142   PMID:7990960   PMID:8117616   PMID:8119964   PMID:8268657   PMID:8382938   PMID:8395349   PMID:8401592  
PMID:8530339   PMID:8541567   PMID:8566784   PMID:8621495   PMID:8639704   PMID:8861958   PMID:8896454   PMID:8917094   PMID:8943350   PMID:8950512   PMID:8950987   PMID:8981362  
PMID:8982467   PMID:9118800   PMID:9152004   PMID:9165114   PMID:9192846   PMID:9199500   PMID:9271117   PMID:9407061   PMID:9480784   PMID:9572484   PMID:9697851   PMID:9784496  
PMID:9843483   PMID:9879712   PMID:9917000   PMID:9927198   PMID:10021334   PMID:10077614   PMID:10092116   PMID:10101119   PMID:10322633   PMID:10333728   PMID:10349621   PMID:10349631  
PMID:10349636   PMID:10469569   PMID:10471511   PMID:10486311   PMID:10547347   PMID:10625553   PMID:10668924   PMID:10706291   PMID:10707901   PMID:10822272   PMID:10842075   PMID:10864459  
PMID:10892744   PMID:10922068   PMID:10960788   PMID:11001926   PMID:11042159   PMID:11044609   PMID:11076861   PMID:11084657   PMID:11130975   PMID:11171333   PMID:11217851   PMID:11287187  
PMID:11435469   PMID:11493536   PMID:11509181   PMID:11555636   PMID:11573961   PMID:11688560   PMID:11733136   PMID:11733383   PMID:11839813   PMID:11889045   PMID:11889558   PMID:11912180  
PMID:11919196   PMID:11969263   PMID:12024052   PMID:12050119   PMID:12130543   PMID:12138137   PMID:12151099   PMID:12223418   PMID:12367587   PMID:12438257   PMID:12466851   PMID:12468434  
PMID:12591246   PMID:12609742   PMID:12619136   PMID:12640141   PMID:12665546   PMID:12729564   PMID:12783782   PMID:12799191   PMID:12882970   PMID:12898605   PMID:12915483   PMID:14517255  
PMID:14595835   PMID:14596929   PMID:14603255   PMID:14628042   PMID:14678822   PMID:14681305   PMID:14681479   PMID:14701728   PMID:14730302   PMID:14736742   PMID:14736876   PMID:14966251  
PMID:15003627   PMID:15063178   PMID:15196959   PMID:15211353   PMID:15329346   PMID:15342464   PMID:15342483   PMID:15376282   PMID:15475264   PMID:15509792   PMID:15533830   PMID:15579507  
PMID:15607745   PMID:15618518   PMID:15716344   PMID:15836771   PMID:15855632   PMID:15923608   PMID:15944188   PMID:15944191   PMID:15970507   PMID:15994295   PMID:16049112   PMID:16054034  
PMID:16141072   PMID:16141073   PMID:16223478   PMID:16245160   PMID:16264195   PMID:16284122   PMID:16287848   PMID:16291795   PMID:16319112   PMID:16319116   PMID:16418481   PMID:16442091  
PMID:16466956   PMID:16467207   PMID:16488114   PMID:16498405   PMID:16510507   PMID:16511601   PMID:16571910   PMID:16602821   PMID:16614054   PMID:16698800   PMID:16738405   PMID:16790474  
PMID:16822657   PMID:16839542   PMID:16847066   PMID:16850025   PMID:16877546   PMID:16920711   PMID:16942767   PMID:16967512   PMID:17035289   PMID:17036046   PMID:17056598   PMID:17071579  
PMID:17109636   PMID:17164647   PMID:17167543   PMID:17172448   PMID:17229764   PMID:17238175   PMID:17300925   PMID:17314325   PMID:17420277   PMID:17425782   PMID:17460146   PMID:17525726  
PMID:17537792   PMID:17537799   PMID:17540364   PMID:17615577   PMID:17673674   PMID:17803355   PMID:17826763   PMID:17855428   PMID:17923686   PMID:17940140   PMID:17992115   PMID:18028902  
PMID:18040647   PMID:18046313   PMID:18082680   PMID:18178801   PMID:18265012   PMID:18272846   PMID:18287559   PMID:18367606   PMID:18391535   PMID:18403409   PMID:18424770   PMID:18445271  
PMID:18480752   PMID:18568026   PMID:18604206   PMID:18618131   PMID:18651984   PMID:18666806   PMID:18718461   PMID:18722343   PMID:18725519   PMID:18755794   PMID:18774569   PMID:18787044  
PMID:18799546   PMID:18922767   PMID:18948621   PMID:19050011   PMID:19097191   PMID:19124014   PMID:19149881   PMID:19301398   PMID:19325248   PMID:19327148   PMID:19369973   PMID:19411759  
PMID:19448158   PMID:19457926   PMID:19501082   PMID:19549635   PMID:19591821   PMID:19696014   PMID:19715689   PMID:19797313   PMID:19809516   PMID:19820125   PMID:19842175   PMID:19864318  
PMID:19876815   PMID:19884258   PMID:19898483   PMID:19914233   PMID:19914235   PMID:19956686   PMID:19998061   PMID:20023660   PMID:20025864   PMID:20040500   PMID:20048339   PMID:20080099  
PMID:20159597   PMID:20185795   PMID:20211142   PMID:20215353   PMID:20235219   PMID:20299672   PMID:20336138   PMID:20375015   PMID:20412781   PMID:20619341   PMID:20643355   PMID:20658695  
PMID:20811903   PMID:20843830   PMID:20943750   PMID:20944551   PMID:20962046   PMID:20972333   PMID:20974136   PMID:21035938   PMID:21123950   PMID:21167960   PMID:21187647   PMID:21248786  
PMID:21252157   PMID:21266775   PMID:21270765   PMID:21281623   PMID:21281624   PMID:21289056   PMID:21294146   PMID:21295565   PMID:21311046   PMID:21343363   PMID:21350012   PMID:21350214  
PMID:21364285   PMID:21378168   PMID:21385577   PMID:21402589   PMID:21420949   PMID:21447555   PMID:21447831   PMID:21491542   PMID:21505261   PMID:21512159   PMID:21533152   PMID:21571217  
PMID:21601656   PMID:21613322   PMID:21654746   PMID:21663736   PMID:21677750   PMID:21719793   PMID:21750042   PMID:21757651   PMID:21858045   PMID:21858105   PMID:21863216   PMID:21871065  
PMID:21871842   PMID:21871877   PMID:21873635   PMID:21888672   PMID:21905163   PMID:21914126   PMID:21931791   PMID:21932312   PMID:21963425   PMID:22012595   PMID:22021707   PMID:22030397  
PMID:22069478   PMID:22110055   PMID:22158707   PMID:22186409   PMID:22216009   PMID:22249313   PMID:22298767   PMID:22343712   PMID:22412967   PMID:22421048   PMID:22465478   PMID:22496664  
PMID:22510988   PMID:22511595   PMID:22525006   PMID:22535408   PMID:22536403   PMID:22544714   PMID:22546693   PMID:22687751   PMID:22693350   PMID:22698282   PMID:22738954   PMID:22797524  
PMID:22826212   PMID:22835934   PMID:22837482   PMID:22840396   PMID:22880115   PMID:22911783   PMID:22926762   PMID:22932389   PMID:22956684   PMID:22962329   PMID:22975322   PMID:22984579  
PMID:22984617   PMID:22988430   PMID:23048191   PMID:23064016   PMID:23071697   PMID:23091613   PMID:23095233   PMID:23095882   PMID:23097346   PMID:23102581   PMID:23139287   PMID:23201013  
PMID:23235565   PMID:23255421   PMID:23288785   PMID:23325811   PMID:23326390   PMID:23345421   PMID:23360989   PMID:23362348   PMID:23362349   PMID:23399488   PMID:23469079   PMID:23487309  
PMID:23497137   PMID:23502960   PMID:23555292   PMID:23559562   PMID:23562652   PMID:23616593   PMID:23650387   PMID:23661704   PMID:23661808   PMID:23685333   PMID:23704941   PMID:23762375  
PMID:23769843   PMID:23797856   PMID:23806616   PMID:23812634   PMID:23824190   PMID:23840809   PMID:23873370   PMID:23874227   PMID:23900076   PMID:23935527   PMID:23951403   PMID:23987514  
PMID:24000064   PMID:24009315   PMID:24009519   PMID:24045698   PMID:24123312   PMID:24129152   PMID:24130328   PMID:24135228   PMID:24278332   PMID:24332837   PMID:24335256   PMID:24353058  
PMID:24365888   PMID:24370450   PMID:24380800   PMID:24403445   PMID:24415412   PMID:24439384   PMID:24451388   PMID:24500693   PMID:24550112   PMID:24571983   PMID:24598167   PMID:24609269  
PMID:24637293   PMID:24650916   PMID:24680892   PMID:24727670   PMID:24732380   PMID:24733830   PMID:24744442   PMID:24784881   PMID:24803588   PMID:24899573   PMID:24937432   PMID:25030234  
PMID:25031030   PMID:25037221   PMID:25071087   PMID:25079229   PMID:25143383   PMID:25145929   PMID:25150979   PMID:25168025   PMID:25245104   PMID:25263278   PMID:25271623   PMID:25336526  
PMID:25358792   PMID:25422104   PMID:25458011   PMID:25491731   PMID:25510679   PMID:25516967   PMID:25556170   PMID:25587123   PMID:25587709   PMID:25596547   PMID:25601757   PMID:25609427  
PMID:25617744   PMID:25647637   PMID:25651362   PMID:25668066   PMID:25681586   PMID:25683803   PMID:25713029   PMID:25739037   PMID:25775596   PMID:25803581   PMID:25804736   PMID:25810472  
PMID:25917826   PMID:25961914   PMID:25992544   PMID:25993318   PMID:26035382   PMID:26049137   PMID:26054850   PMID:26102480   PMID:26116176   PMID:26116661   PMID:26116666   PMID:26123487  
PMID:26141512   PMID:26158450   PMID:26199344   PMID:26265072   PMID:26278035   PMID:26371248   PMID:26375005   PMID:26385183   PMID:26390289   PMID:26438731   PMID:26493106   PMID:26511275  
PMID:26527381   PMID:26572137   PMID:26598235   PMID:26604140   PMID:26655220   PMID:26658320   PMID:26659641   PMID:26687508   PMID:26726844   PMID:26739565   PMID:26776520   PMID:26821812  
PMID:26822476   PMID:26859289   PMID:26902285   PMID:26936393   PMID:26988120   PMID:27056206   PMID:27084889   PMID:27120339   PMID:27149259   PMID:27150455   PMID:27160901   PMID:27180624  
PMID:27228460   PMID:27253890   PMID:27313319   PMID:27328324   PMID:27442016   PMID:27575556   PMID:27578795   PMID:27580238   PMID:27591083   PMID:27597235   PMID:27621062   PMID:27633993  
PMID:27642710   PMID:27650733   PMID:27667021   PMID:27752085   PMID:27798236   PMID:27803039   PMID:27820600   PMID:27882344   PMID:27888191   PMID:27895076   PMID:27930960   PMID:28036337  
PMID:28096344   PMID:28165342   PMID:28195173   PMID:28207192   PMID:28280206   PMID:28287088   PMID:28289143   PMID:28315733   PMID:28334862   PMID:28334964   PMID:28366834   PMID:28370670  
PMID:28426816   PMID:28465335   PMID:28478097   PMID:28536193   PMID:28603487   PMID:28637242   PMID:28687623   PMID:28722653   PMID:28737171   PMID:28760814   PMID:28818950   PMID:28847650  
PMID:28900034   PMID:28926609   PMID:28966119   PMID:29025062   PMID:29042436   PMID:29084269   PMID:29113990   PMID:29114040   PMID:29129523   PMID:29145650   PMID:29158444   PMID:29170254  
PMID:29324782   PMID:29377931   PMID:29398135   PMID:29447006   PMID:29449449   PMID:29449451   PMID:29449453   PMID:29459093   PMID:29467410   PMID:29487191   PMID:29665133   PMID:29689192  
PMID:29700121   PMID:29708625   PMID:29712641   PMID:29764841   PMID:29789381   PMID:29791840   PMID:29795630   PMID:29853539   PMID:29859889   PMID:29945868   PMID:29950491   PMID:29956664  
PMID:30040984   PMID:30046000   PMID:30064973   PMID:30135315   PMID:30220628   PMID:30254276   PMID:30367465   PMID:30375389   PMID:30377232   PMID:30450160   PMID:30456369   PMID:30518531  
PMID:30541888   PMID:30578339   PMID:30635573   PMID:30641926   PMID:30702346   PMID:30763305   PMID:30824610   PMID:30840882   PMID:30853441   PMID:30939177   PMID:30943054   PMID:31028197  
PMID:31062503   PMID:31142573   PMID:31167803   PMID:31231034   PMID:31300484   PMID:31373834   PMID:31405951   PMID:31434897   PMID:31530896   PMID:31575647   PMID:31615982   PMID:31624071  
PMID:31685872   PMID:31787878   PMID:31870435   PMID:31923383   PMID:31928974   PMID:32011766   PMID:32027977   PMID:32068311   PMID:32141129   PMID:32203821   PMID:32212902   PMID:32274496  
PMID:32301970   PMID:32324134   PMID:32341451   PMID:32393787   PMID:32493750   PMID:32494737   PMID:32497091   PMID:32504627   PMID:32521264   PMID:32562599   PMID:32580769   PMID:32698004  
PMID:32715478   PMID:32754639   PMID:32852840   PMID:32855417   PMID:32888352   PMID:32945847   PMID:32999071   PMID:33008598   PMID:33113370   PMID:33130914   PMID:33184107   PMID:33245046  
PMID:33315499   PMID:33323382   PMID:33328840   PMID:33373688   PMID:33442887   PMID:33514561   PMID:33718887   PMID:33726497   PMID:33735101   PMID:33760044   PMID:33822475   PMID:33914868  
PMID:33951437   PMID:34015093   PMID:34015468   PMID:34070742   PMID:34152268   PMID:34230480   PMID:34256037   PMID:34260927   PMID:34354169   PMID:34368133   PMID:34428401   PMID:34448450  
PMID:34508900   PMID:34542814   PMID:34623260   PMID:34697144   PMID:34737300   PMID:34815802   PMID:34846543   PMID:34906895   PMID:35084365   PMID:35178390   PMID:35244683   PMID:35341793  
PMID:35440090   PMID:35451473   PMID:35482005   PMID:35523176   PMID:35704566   PMID:35706902   PMID:35739118   PMID:35877077   PMID:35905011   PMID:35918150   PMID:36057632   PMID:36265442  
PMID:36362374   PMID:36403857   PMID:36445780   PMID:36522157   PMID:36539615   PMID:36543770   PMID:36546838   PMID:36575170   PMID:36577717   PMID:36653444   PMID:36718792   PMID:36719987  
PMID:36795484   PMID:36852644   PMID:36923529   PMID:36960826   PMID:37037595   PMID:37096042   PMID:37348503   PMID:37439314   PMID:37458435   PMID:37509073   PMID:37689753   PMID:37727504  
PMID:37729199   PMID:37774966   PMID:37818607   PMID:37830039   PMID:37861292   PMID:37917714   PMID:37935281   PMID:37982452   PMID:38078651   PMID:38177914   PMID:38198889   PMID:38295182  
PMID:38355624   PMID:38423183   PMID:38446206   PMID:38482556   PMID:38504059   PMID:38625792   PMID:38653356   PMID:38692273   PMID:38714644   PMID:38831775   PMID:38834239   PMID:38941819  
PMID:39009564   PMID:39125754   PMID:39178848  


Genomics

Comparative Map Data
Wt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392104,956,874 - 105,003,959 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2104,956,874 - 105,003,961 (+)EnsemblGRCm39 Ensembl
GRCm382105,126,529 - 105,173,614 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2105,126,529 - 105,173,616 (+)EnsemblGRCm38mm10GRCm38
MGSCv372104,966,686 - 105,013,771 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362104,927,368 - 104,974,451 (+)NCBIMGSCv36mm8
Celera2106,361,212 - 106,408,919 (+)NCBICelera
Cytogenetic Map2E3NCBI
cM Map255.06NCBI
WT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381132,387,775 - 32,435,539 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1132,387,775 - 32,435,564 (-)EnsemblGRCh38hg38GRCh38
GRCh371132,409,321 - 32,457,085 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361132,365,901 - 32,413,663 (-)NCBINCBI36Build 36hg18NCBI36
Build 341132,365,896 - 32,413,653NCBI
Celera1132,556,060 - 32,603,819 (-)NCBICelera
Cytogenetic Map11p13NCBI
HuRef1132,104,249 - 32,152,010 (-)NCBIHuRef
CHM1_11132,409,251 - 32,457,017 (-)NCBICHM1_1
T2T-CHM13v2.01132,523,264 - 32,571,024 (-)NCBIT2T-CHM13v2.0
Wt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83112,019,721 - 112,068,454 (+)NCBIGRCr8
mRatBN7.2391,566,540 - 91,613,653 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl391,567,001 - 91,613,643 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx395,059,051 - 95,105,563 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03103,657,999 - 103,704,505 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03101,489,766 - 101,536,390 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0395,133,221 - 95,180,574 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl395,133,713 - 95,180,564 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03101,756,056 - 101,802,601 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4390,529,704 - 90,577,280 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1390,463,925 - 90,472,651 (+)NCBI
Celera390,623,287 - 90,669,803 (+)NCBICelera
RH 3.4 Map3720.19RGD
Cytogenetic Map3q33NCBI
Wt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547610,464,616 - 10,504,473 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547610,464,688 - 10,504,473 (-)NCBIChiLan1.0ChiLan1.0
WT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2934,594,171 - 34,645,602 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11134,598,573 - 34,650,053 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01132,349,807 - 32,398,494 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11132,238,720 - 32,282,879 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1132,238,720 - 32,287,249 (-)Ensemblpanpan1.1panPan2
WT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11835,099,660 - 35,148,767 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1835,103,934 - 35,148,000 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1834,713,394 - 34,762,525 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01835,710,611 - 35,759,846 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1835,710,238 - 35,759,076 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11835,281,214 - 35,330,461 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01834,861,742 - 34,911,460 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01835,497,531 - 35,546,777 (+)NCBIUU_Cfam_GSD_1.0
Wt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494732,287,144 - 32,334,902 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365335,411,848 - 5,459,693 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365335,411,949 - 5,459,693 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl228,411,803 - 28,455,997 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1228,411,467 - 28,456,007 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2230,902,160 - 30,946,266 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2p14-q11NCBI
WT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1132,750,300 - 32,801,832 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038129,915,480 - 129,964,047 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476620,900,676 - 20,937,202 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476620,899,546 - 20,937,084 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Wt1
1290 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1912
Count of miRNA genes:485
Interacting mature miRNAs:580
Transcripts:ENSMUST00000111098, ENSMUST00000111099, ENSMUST00000133470, ENSMUST00000139585, ENSMUST00000143043, ENSMUST00000145107, ENSMUST00000146842, ENSMUST00000153944
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11038697Ltpr2d_mLeishmania tropica response 2d (mouse)286095716120095823Mouse
1301330Tbbmd2_mtotal body bone mineral density 2 (mouse)Not determined2100942930134943090Mouse
11038698Ltpr2c_mLeishmania tropica response 2c (mouse)286095716120095823Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
1301909Smdq2_msegregation of mitochondrial DNA QTL 2 (mouse)Not determined292778465126778607Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
11049568Lmr28c_mleishmaniasis resistance 28c (mouse)297123370131123532Mouse
11049569Lmr28d_mleishmaniasis resistance 28d (mouse)297123370131123532Mouse
11528549Sluc31_msusceptibility to lung cancer 31 (mouse)274524117129213005Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31214567105143570Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
11532731Sluc31a_msusceptibility to lung cancer 31a (mouse)288015003122015170Mouse
4141802Ignpq1_mIgA nephropathy QTL 1 (mouse)Not determined2100824060134824269Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294230345154241920Mouse
1301834Bits1_mbitterness sensitivity 1 (mouse)Not determined287440643121440778Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
11041906Lmr28a_mleishmaniasis resistance 28a (mouse)2103095716129213005Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284013198148522175Mouse
1357577Trmq3_mT cell ratio modifier QTL 3 (mouse)Not determined260520612119355518Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
1558901Skmw8_mskeletal muscle weight 8 (mouse)Not determined284008488118008593Mouse
12904935Edlmmq2_mextensor digitorum longus muscle mass QTL 2 (mouse)297210364131210364Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1302071Fembrs1_mfemur breaking strength 1 (mouse)Not determined2100942930134943090Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240885493114910165Mouse
1300852Lmr14_mleishmaniasis resistance 14 (mouse)Not determined286095716120095823Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
1302203Gvhd3_mgraft-versus host disease 3 (mouse)Not determined2100942930134943090Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284013198148667470Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
1301374Cplaq7_mcircadian period of locomotor activity 7 (mouse)Not determined276421483110421651Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
10043894Bw22_mbody weight QTL 22 (mouse)Not determined280895334114895334Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
15092054Egrme5_mearly growth rate, maternal effect 5 (mouse)282190187118004745Mouse
4142223Femwf4_mfemur work to failure 4 (mouse)Not determined88143423122143570Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
11049565Lmr28g_mleishmaniasis resistance 28g (mouse)286095716120095823Mouse
4142088Parms1_mpatched associated RMS 1 (mouse)Not determined74524117114123532Mouse
4141448Mpaps1_mmicrophthalmia anophthalmia susceptibility 1 (mouse)Not determined97028557112115196Mouse
1301098Cd8mts3_mCD8 memory T cell subset 3 (mouse)Not determined291089974125090104Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102630345159941920Mouse
12904954Gmmq2_mgastrocnemius muscle mass QTL 2 (mouse)297210364131210364Mouse

Markers in Region
PMC133868P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382105,143,893 - 105,144,312UniSTSGRCm38
MGSCv372104,984,050 - 104,984,469UniSTSGRCm37
Celera2106,378,485 - 106,378,904UniSTS
Cytogenetic Map2EUniSTS
cM Map258.0UniSTS
PMC186395P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382105,126,050 - 105,126,171UniSTSGRCm38
MGSCv372104,966,207 - 104,966,328UniSTSGRCm37
Celera2106,360,733 - 106,360,854UniSTS
Cytogenetic Map2E3UniSTS
Cytogenetic Map2EUniSTS
cM Map258.0UniSTS
Wt1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2EUniSTS
cM Map258.0UniSTS
Wt1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2EUniSTS
cM Map258.0UniSTS
Wt1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2EUniSTS
cM Map258.0UniSTS
GDB:371630  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382105,126,659 - 105,126,845UniSTSGRCm38
MGSCv372104,966,816 - 104,967,002UniSTSGRCm37
Cytogenetic Map2E3UniSTS
Cytogenetic Map2EUniSTS
cM Map258.0UniSTS
GDB:371627  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382105,126,528 - 105,126,735UniSTSGRCm38
MGSCv372104,966,685 - 104,966,892UniSTSGRCm37
Cytogenetic Map2E3UniSTS
Cytogenetic Map2EUniSTS
cM Map258.0UniSTS
WT  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382105,173,280 - 105,173,422UniSTSGRCm38
MGSCv372105,013,437 - 105,013,579UniSTSGRCm37
Celera2106,408,586 - 106,408,727UniSTS
Cytogenetic Map2EUniSTS
cM Map258.0UniSTS
Wt1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2EUniSTS
cM Map258.0UniSTS
Wt1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382105,172,381 - 105,172,799UniSTSGRCm38
MGSCv372105,012,538 - 105,012,956UniSTSGRCm37
Celera2106,407,686 - 106,408,105UniSTS
Cytogenetic Map2EUniSTS
cM Map258.0UniSTS
Wt1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2EUniSTS
cM Map258.0UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000111098   ⟹   ENSMUSP00000106727
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2104,961,228 - 105,003,957 (+)Ensembl
GRCm38.p6 Ensembl2105,130,883 - 105,173,612 (+)Ensembl
Ensembl Acc Id: ENSMUST00000111099   ⟹   ENSMUSP00000106728
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2104,961,228 - 105,003,961 (+)Ensembl
GRCm38.p6 Ensembl2105,130,883 - 105,173,616 (+)Ensembl
Ensembl Acc Id: ENSMUST00000133470   ⟹   ENSMUSP00000120054
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2104,957,346 - 105,002,610 (+)Ensembl
GRCm38.p6 Ensembl2105,127,001 - 105,172,265 (+)Ensembl
Ensembl Acc Id: ENSMUST00000139585   ⟹   ENSMUSP00000123592
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2104,957,555 - 105,003,026 (+)Ensembl
GRCm38.p6 Ensembl2105,127,210 - 105,172,681 (+)Ensembl
Ensembl Acc Id: ENSMUST00000143043   ⟹   ENSMUSP00000117891
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2104,956,874 - 105,003,957 (+)Ensembl
GRCm38.p6 Ensembl2105,126,529 - 105,173,612 (+)Ensembl
Ensembl Acc Id: ENSMUST00000145107
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2104,961,145 - 104,964,295 (+)Ensembl
GRCm38.p6 Ensembl2105,130,800 - 105,133,950 (+)Ensembl
Ensembl Acc Id: ENSMUST00000146842   ⟹   ENSMUSP00000120702
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2104,957,341 - 105,002,687 (+)Ensembl
GRCm38.p6 Ensembl2105,126,996 - 105,172,342 (+)Ensembl
Ensembl Acc Id: ENSMUST00000153944
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2104,993,153 - 105,000,356 (+)Ensembl
GRCm38.p6 Ensembl2105,162,808 - 105,170,011 (+)Ensembl
RefSeq Acc Id: NM_144783   ⟹   NP_659032
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392104,956,874 - 105,003,959 (+)NCBI
GRCm382105,126,529 - 105,173,614 (+)ENTREZGENE
MGSCv372104,966,686 - 105,013,771 (+)RGD
Celera2106,361,212 - 106,408,919 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_659032   ⟸   NM_144783
- UniProtKB: F6Y2T6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000106728   ⟸   ENSMUST00000111099
Ensembl Acc Id: ENSMUSP00000106727   ⟸   ENSMUST00000111098
Ensembl Acc Id: ENSMUSP00000123592   ⟸   ENSMUST00000139585
Ensembl Acc Id: ENSMUSP00000117891   ⟸   ENSMUST00000143043
Ensembl Acc Id: ENSMUSP00000120054   ⟸   ENSMUST00000133470
Ensembl Acc Id: ENSMUSP00000120702   ⟸   ENSMUST00000146842
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22561-F1-model_v2 AlphaFold P22561 1-449 view protein structure

Promoters
RGD ID:6830724
Promoter ID:MM_KWN:30871
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Lung
Transcripts:ENSMUST00000111100,   ENSMUST00000111101,   NM_144783,   NR_015462,   OTTMUST00000035576
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362104,967,621 - 104,968,121 (-)MPROMDB
RGD ID:6878126
Promoter ID:EPDNEW_M2514
Type:multiple initiation site
Name:Wt1_1
Description:Mus musculus Wilms tumor 1 homolog , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382105,126,619 - 105,126,679EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98968 AgrOrtholog
Ensembl Genes ENSMUSG00000016458 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000111098.8 UniProtKB/TrEMBL
  ENSMUST00000111099.2 UniProtKB/TrEMBL
  ENSMUST00000133470.8 UniProtKB/TrEMBL
  ENSMUST00000139585.8 UniProtKB/TrEMBL
  ENSMUST00000143043 ENTREZGENE
  ENSMUST00000143043.8 UniProtKB/TrEMBL
  ENSMUST00000146842.8 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Wilms_tumour_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22431 UniProtKB/TrEMBL
MGD MGI:98968 ENTREZGENE
NCBI Gene 22431 ENTREZGENE
PANTHER KRUEPPEL-LIKE FACTOR 10 UniProtKB/TrEMBL
  KRUEPPEL-LIKE FACTOR 17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WILMS TUMOR PROTEIN UniProtKB/TrEMBL
Pfam WT1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Wt1 PhenoGen
PRINTS WILMSTUMOUR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2A400_MOUSE UniProtKB/TrEMBL
  A2A401_MOUSE UniProtKB/TrEMBL
  A2A404_MOUSE UniProtKB/TrEMBL
  A2A405_MOUSE UniProtKB/TrEMBL
  F6VXG5_MOUSE UniProtKB/TrEMBL
  F6Y2T6 ENTREZGENE, UniProtKB/TrEMBL
  P22561 ENTREZGENE
  Q199A7_MOUSE UniProtKB/TrEMBL
  V9GZH3_MOUSE UniProtKB/TrEMBL
  WT1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary A2A402 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-08-03 Wt1  WT1 transcription factor  Wt1  Wilms tumor 1 homolog  Symbol and/or name change 5135510 APPROVED