Tyr (tyrosinase) - Rat Genome Database

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Gene: Tyr (tyrosinase) Mus musculus
Analyze
Symbol: Tyr
Name: tyrosinase
RGD ID: 11466
MGI Page MGI
Description: Enables protein homodimerization activity. Acts upstream of or within several processes, including melanin biosynthetic process; pigmentation; and thymus development. Located in melanosome. Is expressed in central nervous system; eye; head mesenchyme; mesenchyme derived from neural crest; and skin. Used to study buphthalmos and oculocutaneous albinism. Human ortholog(s) of this gene implicated in several diseases, including melanoma (multiple); ocular albinism 1; oculocutaneous albinism (multiple); retinoschisis; and vitiligo. Orthologous to human TYR (tyrosinase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: albino; albino locus protein; c; monophenol monooxygenase; Oc; Oca1; skc3; skc35
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39787,073,979 - 87,142,637 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl787,073,979 - 87,142,720 (-)EnsemblGRCm39 Ensembl
GRCm38787,424,771 - 87,493,512 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl787,424,771 - 87,493,512 (-)EnsemblGRCm38mm10GRCm38
MGSCv37794,575,915 - 94,641,921 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36787,303,166 - 87,369,172 (-)NCBIMGSCv36mm8
Celera784,786,868 - 84,854,808 (-)NCBICelera
Cytogenetic Map7D3NCBI
cM Map749.01NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinic acid  (ISO)
17beta-estradiol  (EXP)
1H-imidazole  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3-(3,4-dihydroxyphenyl)propanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-phenylpropionic acid  (ISO)
4-hydroxynon-2-enal  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
9-cis-retinal  (ISO)
9-cis-retinoic acid  (ISO)
actinomycin D  (ISO)
afzelin  (ISO)
Alisol B  (EXP)
all-trans-retinoic acid  (EXP)
alpha-melanocyte stimulating hormone  (EXP)
amentoflavone  (ISO)
amikacin  (ISO)
apigenin  (EXP)
atrazine  (ISO)
bathocuproine disulfonic acid  (ISO)
benzo[a]pyrene  (EXP)
beta-ionone  (ISO)
biochanin A  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cannabidiol  (ISO)
carnosic acid  (EXP)
Carnosol  (EXP)
chaetocin  (EXP)
chlorogenic acid  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
chrysin  (EXP)
cis-caffeic acid  (ISO)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
cordycepin  (EXP)
cyanamide  (ISO)
cycloheximide  (EXP,ISO)
daidzein  (EXP)
dibenziodolium  (EXP)
diclofenac  (EXP)
dimercaprol  (ISO)
dopachrome  (EXP)
emodin  (ISO)
epoxiconazole  (EXP)
estriol  (EXP)
ethylenediamine  (ISO)
ethylparaben  (ISO)
fenofibrate  (EXP)
ferulic acid  (ISO)
fulvestrant  (ISO)
galangin  (EXP)
genistein  (EXP)
geranic acid  (EXP)
glabridin  (EXP)
glutathione  (ISO)
glycidol  (ISO)
hydroquinone  (ISO)
hydroquinone O-beta-D-glucopyranoside  (EXP)
isorhamnetin  (EXP)
kenpaullone  (EXP)
kojic acid  (EXP,ISO)
L-ascorbic acid  (ISO)
lawsone  (EXP)
loliolide  (EXP)
luteolin  (EXP)
LY294002  (EXP,ISO)
mefenamic acid  (EXP)
melanins  (EXP,ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-N-nitrosourea  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
nicotinamide  (ISO)
nimesulide  (EXP)
nonanedioic acid  (EXP)
omacetaxine mepesuccinate  (EXP)
omeprazole  (EXP,ISO)
phenethyl caffeate  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phytol  (EXP)
pifithrin-alpha hydrobromide  (ISO)
prazosin  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resorcinol  (EXP,ISO)
resveratrol  (EXP,ISO)
rottlerin  (EXP)
sanguinarine  (EXP)
SB 203580  (EXP,ISO)
scoparone  (EXP)
stilbenoid  (EXP)
sulforaphane  (EXP)
Sweroside  (EXP)
taurine  (EXP)
testosterone  (EXP)
theophylline  (EXP)
trans-caffeic acid  (ISO)
trans-cinnamic acid  (ISO)
trichloroethene  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
vinclozolin  (ISO)
wortmannin  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adrenaline level  (IAGP)
abnormal aqueous drainage system morphology  (IAGP)
abnormal cell morphology  (IAGP)
abnormal cell nucleus morphology  (IAGP)
abnormal cervical axis morphology  (IAGP)
abnormal choroid melanin granule morphology  (IAGP)
abnormal chromosome morphology  (IAGP)
abnormal coat appearance  (IEA)
abnormal coat/hair pigmentation  (IAGP)
abnormal contextual conditioning behavior  (IAGP)
abnormal eye physiology  (IAGP)
abnormal eye pigmentation  (IAGP)
abnormal hair follicle melanocyte morphology  (IAGP)
abnormal hair follicle melanogenesis  (IAGP)
abnormal hair follicle pheomelanosome pheomelanin content  (IEA)
abnormal intraocular pressure  (IAGP)
abnormal iridocorneal angle  (IAGP)
abnormal iris pigmentation  (IAGP)
abnormal keratinocyte apoptosis  (IAGP)
abnormal lens morphology  (IEA)
abnormal limb bud morphology  (IAGP)
abnormal locomotor behavior  (IEA)
abnormal melanogenesis  (IAGP)
abnormal melanosome morphology  (IAGP)
abnormal nest building behavior  (IAGP)
abnormal noradrenaline level  (IAGP)
abnormal physiological response to xenobiotic  (IAGP)
abnormal retina ganglion layer morphology  (IAGP)
abnormal retina melanin granule morphology  (IAGP)
abnormal retina morphology  (IAGP)
abnormal retina photoreceptor morphology  (IAGP)
abnormal skin pigmentation  (IAGP)
abnormal social investigation  (IAGP)
abnormal social/conspecific interaction behavior  (IAGP)
abnormal survival  (IEA)
abnormal tail pigmentation  (IEA)
abnormal trabecular meshwork morphology  (IAGP)
abnormal vasculogenesis  (IAGP)
abnormal vision  (IAGP)
abnormal vitamin A metabolism  (IAGP)
absent coat pigmentation  (IAGP)
absent eye pigmentation  (IAGP)
absent hair follicle melanin granules  (IAGP)
absent mesoderm  (IAGP)
absent Schlemm's canal  (IAGP)
absent seminal vesicle  (IEA)
absent skin pigmentation  (IAGP)
anterior iris synechia  (IAGP)
belly spot  (IEA)
cataract  (IEA)
chromosome breakage  (IAGP)
clonic seizures  (IAGP)
decreased a-wave amplitude  (IAGP)
decreased abdominal fat pad weight  (IAGP)
decreased b-wave amplitude  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased brain weight  (IAGP)
decreased circulating interferon-alpha level  (IAGP)
decreased circulating interferon-beta level  (IAGP)
decreased dopamine level  (IAGP)
decreased ear pigmentation  (IEA)
decreased exploration in new environment  (IAGP)
decreased eye pigmentation  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased retina photoreceptor cell number  (IAGP)
decreased survivor rate  (IEA)
decreased susceptibility to bacterial infection  (IAGP)
decreased tail pigmentation  (IEA)
decreased vertical activity  (IAGP)
decreased vocalization  (IAGP)
diluted coat color  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality at implantation, complete penetrance  (IAGP)
embryonic lethality before implantation, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enhanced AMPA-mediated synaptic currents  (IAGP)
enhanced NMDA-mediated synaptic currents  (IAGP)
failure of zygotic cell division  (IAGP)
failure to gastrulate  (IAGP)
female infertility  (IEA)
hyperactivity  (IAGP)
hypopigmentation  (IEA)
increased anxiety-related response  (IAGP)
increased cellular sensitivity to ionizing radiation  (IAGP)
increased glioblastoma incidence  (IAGP)
increased miniature excitatory postsynaptic current frequency  (IAGP)
increased miscarriage rate  (IEA)
increased tumor growth/size  (IAGP)
induced chromosome breakage  (IAGP)
iris synechia  (IAGP)
irregular coat pigmentation  (IAGP)
kinked neural tube  (IAGP)
lumbar vertebral fusion  (IAGP)
male infertility  (IEA)
mottled coat  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
ocular albinism  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
retina degeneration  (IAGP)
seizures  (IAGP)
shiny fur  (IEA)
single kidney  (IEA)
small embryonic epiblast  (IAGP)
thoracic vertebral fusion  (IAGP)
transverse fur striping  (IAGP)
variegated coat color  (IAGP)
variegated eye pigmentation pattern  (IEA)
yellow coat color  (IEA)
References

References - curated
# Reference Title Reference Citation
1. Tyrosinase as an autoantigen in patients with vitiligo. Baharav E, etal., Clin Exp Immunol. 1996 Jul;105(1):84-8.
2. A Tyrosinase missense mutation causes albinism in the Wistar rat. Blaszczyk WM, etal., Pigment Cell Res. 2005 Apr;18(2):144-5.
3. Immunity to melanin and to tyrosinase in melanoma patients, and in people with vitiligo. Dordic M, etal., BMC Complement Altern Med. 2012 Jul 26;12:109.
4. Autosomal recessive ocular albinism associated with a functionally significant tyrosinase gene polymorphism. Fukai K, etal., Nat Genet. 1995 Jan;9(1):92-5.
5. AAV-mediated tyrosinase gene transfer restores melanogenesis and retinal function in a model of oculo-cutaneous albinism type I (OCA1). Gargiulo A, etal., Mol Ther. 2009 Aug;17(8):1347-54. doi: 10.1038/mt.2009.112. Epub 2009 May 12.
6. A transgenic mouse model with inducible Tyrosinase gene expression using the tetracycline (Tet-on) system allows regulated rescue of abnormal chiasmatic projections found in albinism. Gimenez E, etal., Pigment Cell Res. 2004 Aug;17(4):363-70.
7. Assessment of tyrosinase variants and skin cancer risk in a large cohort of French subjects. Hu HH, etal., J Dermatol Sci. 2011 Nov;64(2):127-33. doi: 10.1016/j.jdermsci.2011.07.003. Epub 2011 Aug 22.
8. Tyrosinase is the modifier of retinoschisis in mice. Johnson BA, etal., Genetics. 2010 Dec;186(4):1337-44. doi: 10.1534/genetics.110.120840. Epub 2010 Sep 27.
9. Mutation spectrum of the TYR and SLC45A2 genes in patients with oculocutaneous albinism. Ko JM, etal., Mol Med Rep. 2012 Apr;5(4):943-8. doi: 10.3892/mmr.2012.764. Epub 2012 Jan 25.
10. Peripheral blood tyrosinase messenger RNA detection and survival in malignant melanoma. Kunter U, etal., J Natl Cancer Inst. 1996 May 1;88(9):590-4.
11. Molecular basis of mouse Himalayan mutation. Kwon BS, etal., Biochem Biophys Res Commun. 1989 May 30;161(1):252-60.
12. A novel missense mutation of the TYR gene in a pedigree with oculocutaneous albinism type 1 from China. Lin YY, etal., Chin Med J (Engl). 2011 Oct;124(20):3358-61.
13. Tyrosinase gene (TYR) mutations in Chinese patients with oculocutaneous albinism type 1. Liu J, etal., Clin Experiment Ophthalmol. 2010 Jan;38(1):37-42. doi: 10.1111/j.1442-9071.2009.02220.x.
14. Efficient gene targeting by TAL effector nucleases coinjected with exonucleases in zygotes. Mashimo T, etal., Sci Rep. 2013;3:1253. doi: 10.1038/srep01253. Epub 2013 Feb 13.
15. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
16. MGDs mouse GO annotations MGD data from the GO Consortium
17. MGD IEA MGD IEA
18. Melanin precursors prevent premature age-related and noise-induced hearing loss in albino mice. Murillo-Cuesta S, etal., Pigment Cell Melanoma Res. 2010 Feb;23(1):72-83. doi: 10.1111/j.1755-148X.2009.00646.x. Epub 2009 Oct 19.
19. Absence of strial melanin coincides with age-associated marginal cell loss and endocochlear potential decline. Ohlemiller KK, etal., Hear Res. 2009 Mar;249(1-2):1-14. doi: 10.1016/j.heares.2008.12.005. Epub 2008 Dec 25.
20. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
21. Mutations of the tyrosinase gene in three Korean patients with type I oculocutaneous albinism. Park KC, etal., Jpn J Hum Genet. 1996 Sep;41(3):299-305.
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
24. Mouse MP Annotation Import Pipeline RGD automated import pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Loss of tyrosinase activity confers increased skin tumor susceptibility in mice. Saran A, etal., Oncogene. 2004 May 20;23(23):4130-5.
28. Molecular basis of dark-eyed albinism in the mouse. Schmidt A and Beermann F, Proc Natl Acad Sci U S A. 1994 May 24;91(11):4756-60.
29. Melanization in albino mice transformed by introducing cloned mouse tyrosinase gene. Tanaka S, etal., Development. 1990 Feb;108(2):223-7.
30. Tyrosinase gene mutations in type I (tyrosinase-deficient) oculocutaneous albinism define two clusters of missense substitutions. Tripathi RK, etal., Am J Med Genet. 1992 Jul 15;43(5):865-71.
31. Prognosis of metastatic melanoma: no correlation of tyrosinase mRNA in bone marrow and survival time. Waldmann V, etal., Recent Results Cancer Res. 2001;158:118-25.
32. [Study of tyrosinase gene mutation in oculocutaneous albinism type 1 patients]. Zheng H, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2011 Aug;27(3):329-32.
Additional References at PubMed
PMID:36985   PMID:62358   PMID:62795   PMID:68973   PMID:93520   PMID:172460   PMID:208984   PMID:273256   PMID:293741   PMID:447069   PMID:447675   PMID:521742  
PMID:522864   PMID:536710   PMID:540025   PMID:549645   PMID:568581   PMID:574104   PMID:621381   PMID:690964   PMID:826246   PMID:863237   PMID:1033984   PMID:1063212  
PMID:1094920   PMID:1133851   PMID:1225761   PMID:1278263   PMID:1280558   PMID:1292010   PMID:1292011   PMID:1292012   PMID:1303276   PMID:1349573   PMID:1349842   PMID:1352884  
PMID:1354647   PMID:1360278   PMID:1362181   PMID:1365899   PMID:1378547   PMID:1409439   PMID:1409440   PMID:1409443   PMID:1409445   PMID:1427844   PMID:1427845   PMID:1507224  
PMID:1535334   PMID:1540161   PMID:1543902   PMID:1543912   PMID:1557387   PMID:1572647   PMID:1617218   PMID:1618394   PMID:1628813   PMID:1638084   PMID:1644288   PMID:1671854  
PMID:1673105   PMID:1679745   PMID:1679753   PMID:1680807   PMID:1684331   PMID:1706745   PMID:1741389   PMID:1744088   PMID:1822431   PMID:1834548   PMID:1889814   PMID:1889815  
PMID:1900251   PMID:1912584   PMID:1952626   PMID:1968044   PMID:1970330   PMID:1970795   PMID:1981054   PMID:2004758   PMID:2040451   PMID:2052619   PMID:2077114   PMID:2110899  
PMID:2118105   PMID:2119500   PMID:2124349   PMID:2137109   PMID:2264930   PMID:2300582   PMID:2304907   PMID:2307474   PMID:2344351   PMID:2378752   PMID:2478463   PMID:2494997  
PMID:2507645   PMID:2517217   PMID:2541065   PMID:2552132   PMID:2706836   PMID:2744450   PMID:2806116   PMID:2813427   PMID:2823263   PMID:2846281   PMID:2859594   PMID:3008521  
PMID:3134020   PMID:3141148   PMID:3146546   PMID:3181757   PMID:3319884   PMID:3378451   PMID:3468297   PMID:3582592   PMID:3596986   PMID:3839762   PMID:3857594   PMID:3866909  
PMID:3899099   PMID:3971387   PMID:4020956   PMID:4141683   PMID:4150768   PMID:4296364   PMID:4343696   PMID:4397868   PMID:4634048   PMID:4747916   PMID:4822986   PMID:4823665  
PMID:4823666   PMID:4841974   PMID:4842093   PMID:4920403   PMID:5005683   PMID:5364923   PMID:5424503   PMID:5527659   PMID:5558564   PMID:5565073   PMID:5902512   PMID:6062374  
PMID:6088946   PMID:6162796   PMID:6276492   PMID:6310574   PMID:6327825   PMID:6328281   PMID:6572398   PMID:6579548   PMID:6585792   PMID:6585968   PMID:6706951   PMID:6785376  
PMID:6793688   PMID:6802749   PMID:7028029   PMID:7117820   PMID:7117836   PMID:7161508   PMID:7262555   PMID:7479744   PMID:7504460   PMID:7558026   PMID:7608332   PMID:7665913  
PMID:7681531   PMID:7688401   PMID:7712116   PMID:7767008   PMID:7774558   PMID:7774957   PMID:7806222   PMID:7813769   PMID:7846052   PMID:7849740   PMID:7852195   PMID:7873577  
PMID:7892256   PMID:7896292   PMID:7920633   PMID:7949739   PMID:7961973   PMID:7963676   PMID:8039502   PMID:8040269   PMID:8040609   PMID:8094303   PMID:8098217   PMID:8099513  
PMID:8114702   PMID:8129415   PMID:8200511   PMID:8223273   PMID:8227355   PMID:8278937   PMID:8307326   PMID:8307327   PMID:8390964   PMID:8422502   PMID:8432998   PMID:8432999  
PMID:8433000   PMID:8433007   PMID:8459851   PMID:8482578   PMID:8499946   PMID:8504252   PMID:8505373   PMID:8570653   PMID:8575777   PMID:8601447   PMID:8626800   PMID:8631264  
PMID:8636124   PMID:8654502   PMID:8661014   PMID:8672126   PMID:8747923   PMID:8747928   PMID:8783939   PMID:8786140   PMID:8787751   PMID:8789201   PMID:8812411   PMID:8812504  
PMID:8833147   PMID:8838319   PMID:8875950   PMID:8884266   PMID:8898882   PMID:8901055   PMID:8903730   PMID:8921397   PMID:8947025   PMID:9008228   PMID:9023352   PMID:9088570  
PMID:9144237   PMID:9168903   PMID:9207131   PMID:9305902   PMID:9335613   PMID:9417870   PMID:9450927   PMID:9477059   PMID:9510032   PMID:9548375   PMID:9636156   PMID:9666083  
PMID:9680387   PMID:9689118   PMID:9722945   PMID:9722956   PMID:9799267   PMID:9808625   PMID:9822646   PMID:9841903   PMID:9880655   PMID:9918801   PMID:10068480   PMID:10087302  
PMID:10212311   PMID:10224267   PMID:10325425   PMID:10348635   PMID:10349636   PMID:10352232   PMID:10369930   PMID:10431243   PMID:10441734   PMID:10485648   PMID:10491617   PMID:10501973  
PMID:10556422   PMID:10583387   PMID:10585447   PMID:10588862   PMID:10596759   PMID:10625389   PMID:10640708   PMID:10665936   PMID:10677587   PMID:10748239   PMID:10760285   PMID:10841032  
PMID:10852913   PMID:10890980   PMID:10995574   PMID:10998130   PMID:11008180   PMID:11042159   PMID:11054672   PMID:11076861   PMID:11095635   PMID:11105050   PMID:11110696   PMID:11209059  
PMID:11214319   PMID:11217851   PMID:11236829   PMID:11238064   PMID:11247670   PMID:11254699   PMID:11266470   PMID:11277491   PMID:11309660   PMID:11391006   PMID:11454769   PMID:11455427  
PMID:11474208   PMID:11493524   PMID:11523704   PMID:11532192   PMID:11587854   PMID:11641724   PMID:11730008   PMID:11839810   PMID:11917121   PMID:11925014   PMID:12028586   PMID:12040030  
PMID:12058062   PMID:12100493   PMID:12100494   PMID:12215665   PMID:12412141   PMID:12427839   PMID:12466851   PMID:12477932   PMID:12624268   PMID:12666202   PMID:12724309   PMID:12829739  
PMID:12832289   PMID:12899938   PMID:12955145   PMID:13545569   PMID:13599016   PMID:13877379   PMID:13880466   PMID:13914573   PMID:13955956   PMID:14051862   PMID:14170399   PMID:14576318  
PMID:14595836   PMID:14622170   PMID:14739285   PMID:14990867   PMID:15161869   PMID:15161941   PMID:15459106   PMID:15477596   PMID:15489520   PMID:15572362   PMID:15576400   PMID:15618488  
PMID:15722110   PMID:15760341   PMID:15826307   PMID:15978262   PMID:15983061   PMID:16141072   PMID:16141073   PMID:16146766   PMID:16162817   PMID:16180137   PMID:16185282   PMID:16199032  
PMID:16261419   PMID:16303920   PMID:16384915   PMID:16602821   PMID:16684884   PMID:16827931   PMID:16847266   PMID:16879986   PMID:16899383   PMID:16988713   PMID:17024248   PMID:17083330  
PMID:17196956   PMID:17202262   PMID:17245945   PMID:17246029   PMID:17246039   PMID:17246054   PMID:17246260   PMID:17247190   PMID:17247200   PMID:17247280   PMID:17247639   PMID:17291453  
PMID:17516930   PMID:17541153   PMID:17541167   PMID:17617591   PMID:17805301   PMID:17850513   PMID:18042623   PMID:18083586   PMID:18117146   PMID:18177347   PMID:18199537   PMID:18237444  
PMID:18272592   PMID:18344445   PMID:18378571   PMID:18385071   PMID:18425346   PMID:18469339   PMID:18568886   PMID:18606814   PMID:18625748   PMID:18641339   PMID:18650808   PMID:18655794  
PMID:18715234   PMID:18890162   PMID:18983533   PMID:19098321   PMID:19155314   PMID:19168892   PMID:19220779   PMID:19299493   PMID:19324852   PMID:19351821   PMID:19456252   PMID:19493314  
PMID:19661232   PMID:19855129   PMID:20041145   PMID:20053998   PMID:20130004   PMID:20444203   PMID:20685971   PMID:21159798   PMID:21191399   PMID:21211561   PMID:21212186   PMID:21337463  
PMID:21364941   PMID:21397665   PMID:21410935   PMID:21494554   PMID:21625383   PMID:21667118   PMID:21677750   PMID:21703427   PMID:21791610   PMID:21873635   PMID:21937600   PMID:21943097  
PMID:21968110   PMID:22094257   PMID:22242171   PMID:22256768   PMID:22275436   PMID:22290436   PMID:22291038   PMID:22474390   PMID:22492037   PMID:22540041   PMID:22561987   PMID:22711892  
PMID:22792072   PMID:22973003   PMID:22993390   PMID:23123854   PMID:23389444   PMID:23423728   PMID:23526936   PMID:23620107   PMID:23708969   PMID:23844102   PMID:23898044   PMID:24124512  
PMID:24355922   PMID:24440150   PMID:24503860   PMID:24562306   PMID:24599260   PMID:24769727   PMID:24875170   PMID:24876386   PMID:24879364   PMID:24884952   PMID:24885435   PMID:25007044  
PMID:25236450   PMID:25273269   PMID:25368159   PMID:25587897   PMID:25713930   PMID:25769612   PMID:25857772   PMID:25957904   PMID:25972253   PMID:26023234   PMID:26048593   PMID:26060116  
PMID:26272364   PMID:26283863   PMID:26321246   PMID:26339033   PMID:26620560   PMID:26656104   PMID:26876013   PMID:27097562   PMID:27224051   PMID:27460988   PMID:27488639   PMID:27526711  
PMID:27804998   PMID:27892516   PMID:27974362   PMID:28040780   PMID:28077650   PMID:28203742   PMID:28330582   PMID:28614705   PMID:28760957   PMID:28771483   PMID:28778995   PMID:28835637  
PMID:29167567   PMID:29295920   PMID:29466759   PMID:29720086   PMID:30174115   PMID:30254141   PMID:30273664   PMID:30448402   PMID:30590377   PMID:31201094   PMID:31260037   PMID:31269433  
PMID:31418010   PMID:31428695   PMID:31570583   PMID:31701200   PMID:31924792   PMID:32078250   PMID:32179091   PMID:32187555   PMID:32313931   PMID:32333523   PMID:32615085   PMID:32795412  
PMID:32797202   PMID:32986721   PMID:33271070   PMID:33290311   PMID:33484482   PMID:33579750   PMID:33852855   PMID:34043941   PMID:34108685   PMID:34193462   PMID:34380032   PMID:34394127  
PMID:34453947   PMID:34702932   PMID:34703992   PMID:34750345   PMID:34941868   PMID:35041655   PMID:35584668   PMID:35675353   PMID:35675768   PMID:35809434   PMID:36083589   PMID:36084545  
PMID:36351424   PMID:36430618   PMID:36525973   PMID:36640762   PMID:36883955   PMID:36944331   PMID:37092554   PMID:37477898   PMID:37660443   PMID:37767784   PMID:37809077   PMID:37821525  
PMID:37992688   PMID:38015750   PMID:38054639   PMID:38206276   PMID:38334649   PMID:38376922   PMID:38429261   PMID:38625797   PMID:38664011   PMID:38815582   PMID:38821051   PMID:38893116  
PMID:38983013   PMID:39096902   PMID:39461968  


Genomics

Comparative Map Data
Tyr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39787,073,979 - 87,142,637 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl787,073,979 - 87,142,720 (-)EnsemblGRCm39 Ensembl
GRCm38787,424,771 - 87,493,512 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl787,424,771 - 87,493,512 (-)EnsemblGRCm38mm10GRCm38
MGSCv37794,575,915 - 94,641,921 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36787,303,166 - 87,369,172 (-)NCBIMGSCv36mm8
Celera784,786,868 - 84,854,808 (-)NCBICelera
Cytogenetic Map7D3NCBI
cM Map749.01NCBI
TYR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381189,177,875 - 89,295,759 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1189,177,875 - 89,295,759 (+)EnsemblGRCh38hg38GRCh38
GRCh371188,911,043 - 89,028,927 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361188,550,688 - 88,668,575 (+)NCBINCBI36Build 36hg18NCBI36
Build 341188,550,687 - 88,668,474NCBI
Celera1185,603,013 - 85,720,910 (-)NCBICelera
Cytogenetic Map11q14.3NCBI
HuRef1185,151,456 - 85,265,865 (+)NCBIHuRef
CHM1_11188,794,044 - 88,911,928 (+)NCBICHM1_1
T2T-CHM13v2.01189,097,534 - 89,215,415 (+)NCBIT2T-CHM13v2.0
Tyr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81150,527,687 - 150,622,857 (-)NCBIGRCr8
mRatBN7.21141,115,036 - 141,210,207 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1141,115,036 - 141,210,207 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1149,090,247 - 149,179,011 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01156,260,901 - 156,349,657 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01149,134,804 - 149,223,566 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01151,012,598 - 151,106,802 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1151,012,598 - 151,106,802 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01157,322,968 - 157,416,594 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41143,641,257 - 143,746,315 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1139,445,261 - 139,532,999 (-)NCBICelera
Cytogenetic Map1q32NCBI
Tyr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554144,244,035 - 4,314,001 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554144,244,035 - 4,314,001 (-)NCBIChiLan1.0ChiLan1.0
TYR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2990,055,036 - 90,172,775 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11191,099,017 - 91,216,729 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01184,188,557 - 84,306,686 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11187,769,989 - 87,888,138 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1187,769,606 - 87,888,138 (+)Ensemblpanpan1.1panPan2
TYR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12110,799,940 - 10,894,187 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2110,799,940 - 10,894,191 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2110,649,581 - 10,749,918 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02110,980,195 - 11,074,816 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2110,980,195 - 11,074,820 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12110,768,466 - 10,862,962 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02110,834,102 - 10,934,647 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02110,884,281 - 10,984,898 (-)NCBIUU_Cfam_GSD_1.0
Tyr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494774,823,234 - 74,920,675 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936736421,598 - 519,253 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936736421,623 - 519,085 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TYR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl922,517,047 - 22,604,290 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1922,517,047 - 22,604,290 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2925,164,768 - 25,214,580 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TYR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1180,330,051 - 80,444,646 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604345,283,848 - 45,401,720 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tyr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624845844,293 - 933,098 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624845844,492 - 933,098 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tyr
3651 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:594
Count of miRNA genes:366
Interacting mature miRNAs:433
Transcripts:ENSMUST00000004770
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)774849748122199223Mouse
25314305Vmm6_mvariable multisystem mineralization 6, eye (mouse)761849748102749207Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
26884381Bzwq2_mbi-zygomatic width QTL 2, 5 week (mouse)76524974896949207Mouse
1301784Ses2_msalmonella enteritidis susceptibility 2 (mouse)Not determined767290094101290240Mouse
1301663Skull9_mskull morphology 9 (mouse)Not determined75732612191326352Mouse
14746989Manh62_mmandible shape 62 (mouse)775742528109742528Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse
27226765Tibl18_mtibia length 18, 16 week (mouse)781849748126499172Mouse
1301383Aem2_manti-erythrocyte autoantibody modifier 2 (mouse)Not determined76413542498135653Mouse
27226763Feml20_mfemur length 20, 16 week (mouse)785049208124199223Mouse
1302155Alcp11_malcohol preference locus 11 (mouse)Not determined78707397987142720Mouse
1301514Rigs1_mradiation induced gastroschisis 1 (mouse)Not determined73628001592394346Mouse
4142500Morq1_mmodifier of Rs1 QTL 1 (mouse)Not determined80551681114551791Mouse
27095937Ulnl7_mulna length 7, 10 week (mouse)76644974898349207Mouse
1301647Elpt_melevated leptin (mouse)Not determined786500186120500329Mouse
11565101Tsve1_mvariable short tail (Tsv) enhancer 1 (mouse)75588950887142720Mouse
1300620Pgia21_mproteoglycan induced arthritis 21 (mouse)Not determined767290094101290240Mouse
13208555Lgth10_mbody length 10 (mouse)751649748125599172Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)761749748121399223Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
1301566Adip3_madiposity 3 (mouse)Not determined775394215109394346Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301155Bpq7_mblood pressure QTL 7 (mouse)Not determined770143137104143379Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
1301671Lorp1_mloss of righting due to propofol 1 (mouse)Not determined78707397987142720Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
27226792Feml7_mfemur length 7, 5 week (mouse)78614920898949207Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
4142212Png1_mPostnatal growth 1 (mouse)Not determined7432612192394346Mouse
1300654Bomd1_mbone mineral density 1 (mouse)Not determined768365595102365702Mouse
1302062Stheal6_msoft tissue heal 6 (mouse)Not determined787043932121044066Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765249748126499172Mouse
27095903Scvln10_msacral vertebrae length 2, 10 week (mouse)781449748126499172Mouse
27226715Metcl3_mmetatarsal-calcaneal length 3, 5 week (mouse)767849748119499223Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)767849748124199223Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)754819589116822815Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
1301465Egrm3_mearly growth rate (mouse)Not determined75732612191326352Mouse
1300952Hcs1_mhepatocarcinogenesis susceptibility 1 (mouse)Not determined75732612191326352Mouse
4142319Powg_mpost-ovarectomy weight gain (mouse)Not determined7285710592582163Mouse
10412110Cctq1_mcentral corneal thickness QTL 1 (mouse)Not determined780551681114551791Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301826Pgia3_mproteoglycan induced arthritis 3 (mouse)Not determined767290094101290240Mouse
1301188Heal6_mwound healing/regeneration 6 (mouse)Not determined787043932121044066Mouse
26884418Bzwq7_mbi-zygomatic width QTL 7, 10 week (mouse)767849748105449207Mouse
10043973Obq29_mobesity QTL 29 (mouse)Not determined772263372106263372Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
1301878Alcp13_malcohol preference locus 13 (mouse)Not determined78707397987142720Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)774849748122199223Mouse
27095930Ulnl10_mulna length 10, 16 week (mouse)780849748126699172Mouse
27095923Pglq3_mpelvic girdle length QTL 3, 5 week (mouse)781249748124199223Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)761749748123699223Mouse
12801463Rta1_mretinal aging 1 (mouse)76716802789089989Mouse
11553865Stmm1c_mskin tumor modifier of MSM 1c (mouse)76578898699788986Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)767849748124999172Mouse
1558894Tlag1_mT lymphoma attenuation gene 1 (mouse)Not determined78707397987142720Mouse
11553866Stmm1d_mskin tumor modifier of MSM 1d (mouse)76578898699788986Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773049748125699172Mouse
13463473Hbbcq4_mhemoglobin concentration QTL 4 (mouse)787043932121044066Mouse
11553869Stmm2b_mskin tumor modifier of MSM 2a (mouse)773725965107725965Mouse
27095907Scvln4_msacral vertebrae length 2, 5 week (mouse)769949748120499223Mouse
1301997Cia7_mcollagen induced arthritis QTL 7 (mouse)Not determined785365595112533819Mouse

Markers in Region
RH133723  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38787,429,026 - 87,429,233UniSTSGRCm38
MGSCv37794,577,536 - 94,577,743UniSTSGRCm37
Celera784,788,487 - 84,788,694UniSTS
Cytogenetic Map7D3-E1UniSTS
M24560  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38787,428,548 - 87,428,747UniSTSGRCm38
MGSCv37794,577,058 - 94,577,257UniSTSGRCm37
Celera784,788,011 - 84,788,210UniSTS
Cytogenetic Map7D3-E1UniSTS
Whitehead/MRC_RH7920.26UniSTS
Whitehead_YAC7 UniSTS
D7Mit19.1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7D3-E1UniSTS
cM Map744.0UniSTS
Whitehead Genetic731.7UniSTS
D7Mit216  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38787,447,195 - 87,447,372UniSTSGRCm38
MGSCv37794,595,705 - 94,595,882UniSTSGRCm37
Celera784,806,663 - 84,806,842UniSTS
Cytogenetic Map7D3-E1UniSTS
cM Map744.0UniSTS
Whitehead Genetic731.7UniSTS
Whitehead/MRC_RH7920.16UniSTS
Whitehead_YAC7 UniSTS
D7Mit19  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38787,429,054 - 87,429,186UniSTSGRCm38
MGSCv37794,577,564 - 94,577,696UniSTSGRCm37
Celera784,788,515 - 84,788,647UniSTS
Cytogenetic Map7D3-E1UniSTS
cM Map744.0UniSTS
Whitehead Genetic731.7UniSTS
D7Mit31  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38787,493,929 - 87,494,171UniSTSGRCm38
MGSCv37794,642,439 - 94,642,681UniSTSGRCm37
Celera784,855,326 - 84,855,568UniSTS
Cytogenetic Map7D3-E1UniSTS
cM Map744.0UniSTS
Whitehead Genetic731.7UniSTS
RH18134  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38787,479,547 - 87,479,752UniSTSGRCm38
MGSCv37794,628,057 - 94,628,262UniSTSGRCm37
Celera784,840,973 - 84,841,178UniSTS
Cytogenetic Map7D3-E1UniSTS
D0Nds35  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38787,428,752 - 87,428,902UniSTSGRCm38
MGSCv37794,577,262 - 94,577,412UniSTSGRCm37
Celera784,788,215 - 84,788,363UniSTS
Cytogenetic Map7D3-E1UniSTS
cM MapUN UniSTS
cM Map7 UniSTS
D0Nds37  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38787,429,084 - 87,429,168UniSTSGRCm38
MGSCv37794,577,594 - 94,577,678UniSTSGRCm37
Celera784,788,545 - 84,788,629UniSTS
Cytogenetic Map7D3-E1UniSTS
cM MapUN UniSTS
cM Map7 UniSTS
Tyr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7D3-E1UniSTS
cM Map744.0UniSTS
Tyr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7D3-E1UniSTS
cM Map744.0UniSTS
M24560  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38787,428,239 - 87,428,345UniSTSGRCm38
MGSCv37794,576,749 - 94,576,855UniSTSGRCm37
Celera784,787,702 - 84,787,808UniSTS
Cytogenetic Map7D3-E1UniSTS
Whitehead/MRC_RH7920.26UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001317397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001417448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC122517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC141329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK014619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY012001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY526904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB571109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC079678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D00131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D00439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D00440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D84001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC760024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC760025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC760026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC760027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M20234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M24560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M26729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X12782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X51743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000004770   ⟹   ENSMUSP00000004770
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl787,073,979 - 87,142,720 (-)Ensembl
GRCm38.p6 Ensembl787,424,771 - 87,493,512 (-)Ensembl
Ensembl Acc Id: ENSMUST00000207164
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl787,118,328 - 87,142,641 (-)Ensembl
GRCm38.p6 Ensembl787,469,120 - 87,493,433 (-)Ensembl
Ensembl Acc Id: ENSMUST00000207834   ⟹   ENSMUSP00000146757
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl787,141,854 - 87,142,600 (-)Ensembl
GRCm38.p6 Ensembl787,492,646 - 87,493,392 (-)Ensembl
RefSeq Acc Id: NM_001317397   ⟹   NP_001304326
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39787,073,979 - 87,142,637 (-)NCBI
GRCm38787,424,771 - 87,493,512 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001417448   ⟹   NP_001404377
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39787,118,328 - 87,142,637 (-)NCBI
RefSeq Acc Id: NM_011661   ⟹   NP_035791
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39787,073,979 - 87,142,637 (-)NCBI
GRCm38787,424,771 - 87,493,512 (-)NCBI
MGSCv37794,575,915 - 94,641,921 (-)RGD
Celera784,786,868 - 84,854,808 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_035791   ⟸   NM_011661
- Peptide Label: isoform 1 precursor
- UniProtKB: P11344 (UniProtKB/Swiss-Prot),   Q91XK0 (UniProtKB/TrEMBL),   Q3UFK9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001304326   ⟸   NM_001317397
- Peptide Label: isoform 2 precursor
- UniProtKB: Q3UFQ7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000146757   ⟸   ENSMUST00000207834
Ensembl Acc Id: ENSMUSP00000004770   ⟸   ENSMUST00000004770
RefSeq Acc Id: NP_001404377   ⟸   NM_001417448
- Peptide Label: isoform 3 precursor
- UniProtKB: Q3UFQ7 (UniProtKB/TrEMBL)
Protein Domains
Tyrosinase copper-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11344-F1-model_v2 AlphaFold P11344 1-533 view protein structure

Promoters
RGD ID:8664707
Promoter ID:EPDNEW_M10384
Type:initiation region
Name:Tyr_1
Description:Mus musculus tyrosinase , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38787,493,429 - 87,493,489EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98880 AgrOrtholog
Ensembl Genes ENSMUSG00000004651 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000004770 ENTREZGENE
  ENSMUST00000004770.7 UniProtKB/Swiss-Prot
  ENSMUST00000207164 ENTREZGENE
  ENSMUST00000207834.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Tyrosinase/Hemocyanin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyrosinase_Cu-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Unchr_di-copper_centre UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22173 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:98880 ENTREZGENE
NCBI Gene 22173 ENTREZGENE
PANTHER TYROSINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYROSINASE FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Tyrosinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tyr PhenoGen
PRINTS TYROSINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TYROSINASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYROSINASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48056 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140LIB9_MOUSE UniProtKB/TrEMBL
  P11344 ENTREZGENE
  Q3UFK9 ENTREZGENE, UniProtKB/TrEMBL
  Q3UFQ7 ENTREZGENE, UniProtKB/TrEMBL
  Q3UFR6_MOUSE UniProtKB/TrEMBL
  Q64ID7_MOUSE UniProtKB/TrEMBL
  Q91XK0 ENTREZGENE, UniProtKB/TrEMBL
  Q99NK7_MOUSE UniProtKB/TrEMBL
  TYRO_MOUSE UniProtKB/Swiss-Prot