Tsc2 (TSC complex subunit 2) - Rat Genome Database

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Gene: Tsc2 (TSC complex subunit 2) Mus musculus
Analyze
Symbol: Tsc2
Name: TSC complex subunit 2
RGD ID: 11457
MGI Page MGI
Description: Enables 14-3-3 protein binding activity. Involved in several processes, including anoikis; chemical synaptic transmission; and negative regulation of TORC1 signaling. Acts upstream of or within several processes, including intracellular protein transport; negative regulation of intracellular signal transduction; and negative regulation of lymphocyte proliferation. Located in cytoplasm. Is active in synapse. Is expressed in several structures, including aorta; central nervous system; genitourinary system; hemolymphoid system gland; and retina. Used to study autism spectrum disorder; tuberous sclerosis; and uterine fibroid. Human ortholog(s) of this gene implicated in hepatic angiomyolipoma; lymphangioleiomyomatosis; medulloblastoma; tuberous sclerosis; and tuberous sclerosis 2. Orthologous to human TSC2 (TSC complex subunit 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Na; Nafld; Tcs2; tube; tuberin; tuberous sclerosis 2; tuberous sclerosis 2 protein homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,814,788 - 24,851,607 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,814,790 - 24,851,604 (-)EnsemblGRCm39 Ensembl
GRCm381724,595,816 - 24,632,676 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,595,816 - 24,632,630 (-)EnsemblGRCm38mm10GRCm38
MGSCv371724,732,882 - 24,769,574 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361724,323,537 - 24,360,229 (-)NCBIMGSCv36mm8
Celera1725,113,932 - 25,155,030 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Hepatitis  (ISO)
acute myeloid leukemia  (ISO)
Alzheimer's disease  (ISO)
angiomyolipoma  (ISO)
Arthralgia  (ISO)
autism spectrum disorder  (IAGP,ISO)
autistic disorder  (ISO)
bone osteosarcoma  (ISO)
brain disease  (ISO)
Brain Neoplasms  (ISO)
breast cancer  (ISO)
Cafe-au-Lait Spots  (ISO)
developmental and epileptic encephalopathy 1  (ISO)
endometrial carcinoma  (ISO)
epilepsy  (ISO)
Experimental Diabetes Mellitus  (ISO)
Female Infertility  (IMP)
Fever  (ISO)
Focal Cortical Dysplasia of Taylor  (ISO)
genetic disease  (ISO)
Hamartoma  (ISO)
hemangioma  (IMP)
hepatic angiomyolipoma  (IAGP)
hepatocellular carcinoma  (IEP)
Hereditary Neoplastic Syndromes  (ISO)
Hirschsprung's disease  (ISO)
idiopathic generalized epilepsy  (ISO)
Inflammation  (ISO)
intellectual disability  (ISO)
Joint Instability  (ISO)
Kidney Neoplasms  (ISO)
leiomyoma  (ISO)
Lung Neoplasms  (ISO)
lymphangioleiomyomatosis  (ISO)
Lymphatic Metastasis  (ISO)
medulloblastoma  (ISO)
Mouth Neoplasms  (ISO)
Nerve Degeneration  (ISO)
Nervous System Malformations  (ISO)
neuroblastoma  (ISO)
Neurodevelopmental Disorders  (ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
polycystic kidney disease  (ISO)
pre-malignant neoplasm  (ISO)
primary coenzyme Q10 deficiency 7  (ISO)
renal cell carcinoma  (IMP,ISO)
Rhabdomyoma  (ISO)
short-rib thoracic dysplasia 9 with or without polydactyly  (ISO)
squamous cell carcinoma  (ISO)
tuberous sclerosis  (IAGP,ISO)
tuberous sclerosis 1  (ISO)
tuberous sclerosis 2  (ISO)
uterine fibroid  (IAGP)
vascular dementia  (ISO)
West syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nonylphenol  (ISO)
4-phenylbutyric acid  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
androgen antagonist  (ISO)
antirheumatic drug  (ISO)
antroquinonol  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP)
azathioprine  (ISO)
Benoxacor  (EXP)
benzene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
Butylparaben  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
captan  (EXP)
cisplatin  (ISO)
colistin  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
DDE  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
enzacamene  (ISO)
epoxiconazole  (EXP,ISO)
fenthion  (EXP)
folpet  (EXP)
GSK690693  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
linuron  (ISO)
lipopolysaccharide  (EXP)
mercury dibromide  (ISO)
methamphetamine  (ISO)
methidathion  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
nickel dichloride  (ISO)
Nonylphenol  (ISO)
ochratoxin A  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
prochloraz  (ISO)
procymidone  (ISO)
quercetin  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (ISO)
sorafenib  (ISO)
sunitinib  (ISO)
Temsirolimus  (ISO)
testosterone  (ISO)
tungsten  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anoikis  (IMP,ISO)
B cell proliferation  (IGI)
cell population proliferation  (IGI,IMP)
cell projection organization  (ISO)
cellular response to insulin stimulus  (IMP)
establishment of cell polarity  (ISO)
excitatory chemical synaptic transmission  (IMP)
glucose import  (IMP)
heart development  (IMP)
inhibitory chemical synaptic transmission  (IMP)
insulin-like growth factor receptor signaling pathway  (IGI,IMP)
negative regulation of axonogenesis  (ISO)
negative regulation of B cell proliferation  (IGI)
negative regulation of cell population proliferation  (IGI,IMP,ISO)
negative regulation of cell size  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of epithelial to mesenchymal transition  (ISO)
negative regulation of fibroblast proliferation  (ISO)
negative regulation of insulin receptor signaling pathway  (IBA)
negative regulation of macroautophagy  (ISO)
negative regulation of MAP kinase activity  (ISO)
negative regulation of phosphatidylinositol 3-kinase signaling  (IMP)
negative regulation of pinocytosis  (ISO)
negative regulation of protein kinase activity  (IMP)
negative regulation of protein kinase B signaling  (IBA,IGI,IMP)
negative regulation of protein phosphorylation  (ISO)
negative regulation of T cell proliferation  (IGI)
negative regulation of TOR signaling  (IBA,IGI,IMP,ISO)
negative regulation of TORC1 signaling  (IMP)
negative regulation of vascular endothelial cell proliferation  (ISO)
negative regulation of Wnt signaling pathway  (IBA,ISO)
neural tube closure  (IMP)
phosphatidylinositol 3-kinase signaling  (IMP)
positive chemotaxis  (IMP)
positive regulation of autophagy  (IMP)
positive regulation of cell adhesion  (ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of fibroblast migration  (ISO)
positive regulation of GTPase activity  (IEA)
positive regulation of macroautophagy  (IMP,ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of transcription by RNA polymerase II  (IMP)
protein import into nucleus  (IMP)
protein kinase B signaling  (IGI,IMP)
protein localization  (IDA)
protein localization to cell surface  (ISO)
protein transport into plasma membrane raft  (IMP)
regulation of cell cycle  (IBA)
regulation of endocytosis  (IMP)
regulation of insulin receptor signaling pathway  (IMP)
regulation of postsynapse organization  (ISO)
regulation of small GTPase mediated signal transduction  (IEA)
response to hypoxia  (IMP)
social behavior  (ISO)
T cell proliferation  (IGI)
transcription by RNA polymerase II  (IMP)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal autophagosome formation  (IAGP)
abnormal autophagy  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal contextual conditioning behavior  (IAGP)
abnormal dendrite morphology  (IAGP)
abnormal dendritic spine morphology  (IAGP)
abnormal embryonic hematopoiesis  (IAGP)
abnormal endocardium morphology  (IAGP)
abnormal gait  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal hippocampus pyramidal cell morphology  (IAGP)
abnormal myometrium morphology  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
abnormal Purkinje cell morphology  (IAGP)
abnormal response to novel object  (IAGP)
abnormal response to social novelty  (IAGP)
abnormal seminiferous tubule epithelium morphology  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal Sertoli cell morphology  (IAGP)
abnormal social investigation  (IAGP)
abnormal spatial learning  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal testis morphology  (IAGP)
abnormal vascular development  (IAGP)
astrocytosis  (IAGP)
ataxia  (IAGP)
decreased body weight  (IAGP)
decreased circulating insulin level  (IAGP)
decreased coping response  (IAGP)
decreased embryo size  (IAGP)
decreased male germ cell number  (IAGP)
decreased myocardial infarct size  (IAGP)
decreased pancreatic beta cell number  (IAGP)
decreased testis weight  (IAGP)
dilated vasculature  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
endometrium hyperplasia  (IAGP)
enhanced long term potentiation  (IAGP)
enlarged uterus  (IAGP)
environmentally induced seizures  (IAGP)
heart hyperplasia  (IAGP)
hypoglycemia  (IAGP)
impaired coordination  (IAGP)
improved glucose tolerance  (IAGP)
incomplete rostral neuropore closure  (IAGP)
increased adenoma incidence  (IAGP)
increased apoptosis  (IAGP)
increased brain size  (IAGP)
increased brain weight  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating insulin level  (IAGP)
increased endometrial gland number  (IAGP)
increased extremity angiosarcoma incidence  (IAGP)
increased hepatic hemangioma incidence  (IAGP)
increased insulin sensitivity  (IAGP)
increased kidney tumor incidence  (IAGP)
increased lung adenoma incidence  (IAGP)
increased lung tumor incidence  (IAGP)
increased metastatic potential  (IAGP)
increased myocardial infarct size  (IAGP)
increased pancreatic beta cell mass  (IAGP)
increased renal carcinoma incidence  (IAGP)
increased renal cystadenoma incidence  (IAGP)
increased Sertoli cell proliferation  (IAGP)
increased tumor incidence  (IAGP)
increased uterus leiomyoma incidence  (IAGP)
increased uterus weight  (IAGP)
increased vertical activity  (IAGP)
internal hemorrhage  (IAGP)
kidney cyst  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
liver hypoplasia  (IAGP)
no abnormal phenotype detected  (IAGP)
open neural tube  (IAGP)
pallor  (IAGP)
pancreatic islet hyperplasia  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
Purkinje cell degeneration  (IAGP)
seizures  (IAGP)
slow postnatal weight gain  (IAGP)
small testis  (IAGP)
thick myocardium  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Tuberous sclerosis complex 2 gene product interacts with human SMAD proteins. A molecular link of two tumor suppressor pathways. Birchenall-Roberts MC, etal., J Biol Chem. 2004 Jun 11;279(24):25605-13. Epub 2004 Apr 2.
2. Hepatic manifestations of tuberous sclerosis complex: a genotypic and phenotypic analysis. Black ME, etal., Clin Genet. 2012 Dec;82(6):552-7. doi: 10.1111/j.1399-0004.2012.01845.x. Epub 2012 Feb 2.
3. Phenotypic characterization of disseminated cells with TSC2 loss of heterozygosity in patients with lymphangioleiomyomatosis. Cai X, etal., Am J Respir Crit Care Med. 2010 Dec 1;182(11):1410-8. doi: 10.1164/rccm.201003-0489OC. Epub 2010 Jul 16.
4. Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis. Carsillo T, etal., Proc Natl Acad Sci U S A. 2000 May 23;97(11):6085-90.
5. Increased expression of tuberin in human uterine leiomyoma. Cui L, etal., Fertil Steril. 2011 Apr;95(5):1805-8. doi: 10.1016/j.fertnstert.2010.11.028. Epub 2010 Dec 10.
6. Regulation of mTORC1 by PI3K signaling. Dibble CC and Cantley LC, Trends Cell Biol. 2015 Sep;25(9):545-55. doi: 10.1016/j.tcb.2015.06.002. Epub 2015 Jul 6.
7. Tuberin--a new molecular target in Alzheimer's disease? Ferrando-Miguel R, etal., Neurochem Res. 2005 Nov;30(11):1413-9.
8. Insight into mechanism of oxidative DNA damage in angiomyolipomas from TSC patients. Habib SL Mol Cancer. 2009 Mar 5;8:13. doi: 10.1186/1476-4598-8-13.
9. Correlation between tuberous sclerosis complex 2 and glycogen synthase kinase 3 beta levels, and outcomes of patients with hepatocellular carcinoma treated by hepatectomy. Huang KT, etal., Hepatol Res. 2014 Oct;44(11):1142-50. doi: 10.1111/hepr.12256. Epub 2013 Nov 8.
10. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Inoki K, etal., Genes Dev. 2003 Aug 1;17(15):1829-34. Epub 2003 Jul 17.
11. Tuberin and hamartin are aberrantly expressed and linked to clinical outcome in human breast cancer: the role of promoter methylation of TSC genes. Jiang WG, etal., Eur J Cancer. 2005 Jul;41(11):1628-36.
12. Hyperplasia and fibrosis in mice with conditional loss of the TSC2 tumor suppressor in Mullerian duct mesenchyme-derived myometria. Kaneko-Tarui T, etal., Mol Hum Reprod. 2014 Nov;20(11):1126-34. doi: 10.1093/molehr/gau077. Epub 2014 Sep 4.
13. Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent. Karbowniczek M, etal., J Biol Chem. 2004 Jul 16;279(29):29930-7. Epub 2004 May 18.
14. Expression and prognostic value of tuberous sclerosis complex 2 gene product tuberin in human pancreatic cancer. Kataoka K, etal., Surgery. 2005 Sep;138(3):450-5.
15. Tctex3, related to Drosophila polycomblike, is expressed in male germ cells and mapped to the mouse t-complex. Kawakami S, etal., Mamm Genome 1998 Nov;9(11):874-80.
16. Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice. Kobayashi T, etal., Cancer Res. 1999 Mar 15;59(6):1206-11.
17. cDNA structure, alternative splicing and exon-intron organization of the predisposing tuberous sclerosis (Tsc2) gene of the Eker rat model. Kobayashi T, etal., Nucleic Acids Res 1995 Jul 25;23(14):2608-13.
18. Molecular mechanisms of mTOR-mediated translational control. Ma XM and Blenis J, Nat Rev Mol Cell Biol. 2009 May;10(5):307-18. Epub 2009 Apr 2.
19. The tuberin-hamartin complex negatively regulates beta-catenin signaling activity. Mak BC, etal., J Biol Chem 2003 Feb 21;278(8):5947-51. Epub 2003 Jan 02.
20. Role of insulin, adipocyte hormones, and nutrient-sensing pathways in regulating fuel metabolism and energy homeostasis: a nutritional perspective of diabetes, obesity, and cancer. Marshall S Sci STKE. 2006 Aug 1;2006(346):re7.
21. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
22. MGDs mouse GO annotations MGD data from the GO Consortium
23. MGD IEA MGD IEA
24. Loss of tuberin from cerebral tissues with tuberous sclerosis and astrocytoma. Mizuguchi M, etal., Ann Neurol. 1996 Dec;40(6):941-4.
25. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
28. Analysis of the TSC2 gene in human medulloblastoma. Przkora R, etal., Acta Neuropathol. 2001 Oct;102(4):380-4.
29. Analysis of 65 tuberous sclerosis complex (TSC) patients by TSC2 DGGE, TSC1/TSC2 MLPA, and TSC1 long-range PCR sequencing, and report of 28 novel mutations. Rendtorff ND, etal., Hum Mutat. 2005 Oct;26(4):374-83.
30. Mouse MP Annotation Import Pipeline RGD automated import pipeline
31. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. Suppression of tumor suppressor Tsc2 and DNA repair glycosylase Nth1 during spontaneous liver tumorigenesis in Long-Evans Cinnamon rats. Sajankila SP, etal., Mol Cell Biochem. 2010 May;338(1-2):233-9. doi: 10.1007/s11010-009-0357-1. Epub 2009 Dec 24.
34. Isolation and characterization of a rat homologue of the human tuberous sclerosis 1 gene (Tsc1) and analysis of its mutations in rat renal carcinomas. Satake N, etal., Cancer Res 1999 Feb 15;59(4):849-55.
35. The G1556S-type tuberin variant suppresses tumor formation in tuberous sclerosis 2 mutant (Eker) rats despite its deficiency in mTOR inhibition. Shiono M, etal., Oncogene. 2008 Nov 6;27(52):6690-7. doi: 10.1038/onc.2008.283. Epub 2008 Aug 11.
36. Mechanism of oxidative DNA damage in diabetes: tuberin inactivation and downregulation of DNA repair enzyme 8-oxo-7,8-dihydro-2'-deoxyguanosine-DNA glycosylase. Simone S, etal., Diabetes. 2008 Oct;57(10):2626-36. doi: 10.2337/db07-1579. Epub 2008 Jul 3.
37. Epilepsy and Tsc2 haploinsufficiency lead to autistic-like social deficit behaviors in rats. Waltereit R, etal., Behav Genet. 2011 May;41(3):364-72. doi: 10.1007/s10519-010-9399-0. Epub 2010 Oct 7.
38. Hepatic angiomyolipoma: mutation analysis and immunohistochemical pitfalls in diagnosis. Yan Z, etal., Histopathology. 2018 Jul;73(1):101-108. doi: 10.1111/his.13509. Epub 2018 Apr 19.
39. Tuberous sclerosis-2 tumor suppressor modulates ERK and B-Raf activity in transformed renal epithelial cells. Yoon HS, etal., Am J Physiol Renal Physiol. 2004 Feb;286(2):F417-24. Epub 2003 Nov 11.
Additional References at PubMed
PMID:7558029   PMID:7601476   PMID:7774953   PMID:8661056   PMID:8777431   PMID:8828041   PMID:8833243   PMID:8945939   PMID:9072957   PMID:9226367   PMID:9743625   PMID:10349636  
PMID:10458911   PMID:10491404   PMID:10584558   PMID:10677526   PMID:10827137   PMID:11030407   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11290735   PMID:11438694   PMID:11703097  
PMID:11741832   PMID:11875047   PMID:12037687   PMID:12150915   PMID:12403809   PMID:12438748   PMID:12466851   PMID:12477932   PMID:12504590   PMID:12783884   PMID:12957289   PMID:14561707  
PMID:14651849   PMID:14993219   PMID:15249583   PMID:15355997   PMID:15545625   PMID:15578690   PMID:15772076   PMID:15782199   PMID:15851026   PMID:15972957   PMID:16027168   PMID:16027169  
PMID:16141072   PMID:16141073   PMID:16286931   PMID:16390268   PMID:16452087   PMID:16602821   PMID:16702951   PMID:16959613   PMID:17015619   PMID:17077083   PMID:17244624   PMID:17245776  
PMID:17273797   PMID:17355907   PMID:17458623   PMID:17470459   PMID:17562867   PMID:17658474   PMID:17942919   PMID:17962806   PMID:17989114   PMID:18198340   PMID:18230340   PMID:18316403  
PMID:18320306   PMID:18342602   PMID:18344980   PMID:18373617   PMID:18411301   PMID:18511518   PMID:18568033   PMID:18587048   PMID:18692468   PMID:18701472   PMID:18794346   PMID:18845692  
PMID:18949383   PMID:18974095   PMID:19047368   PMID:19068483   PMID:19150975   PMID:19255143   PMID:19321600   PMID:19357198   PMID:19395652   PMID:19398581   PMID:19527517   PMID:19593385  
PMID:19602587   PMID:19620286   PMID:19648120   PMID:19843635   PMID:20038814   PMID:20042714   PMID:20062052   PMID:20145209   PMID:20146790   PMID:20159776   PMID:20169165   PMID:20399730  
PMID:20412061   PMID:20427478   PMID:20453062   PMID:20534473   PMID:20615870   PMID:20616807   PMID:20665729   PMID:20813961   PMID:20882401   PMID:21062901   PMID:21079609   PMID:21134130  
PMID:21205090   PMID:21238928   PMID:21267068   PMID:21383064   PMID:21387562   PMID:21419848   PMID:21436046   PMID:21482669   PMID:21500191   PMID:21737790   PMID:21746920   PMID:21784859  
PMID:21795849   PMID:21804531   PMID:21873635   PMID:21886784   PMID:21896734   PMID:22055460   PMID:22056141   PMID:22113615   PMID:22198573   PMID:22343943   PMID:22363451   PMID:22363765  
PMID:22492229   PMID:22532572   PMID:22628617   PMID:22752306   PMID:22791749   PMID:22795129   PMID:22798074   PMID:22840514   PMID:22916036   PMID:22923640   PMID:23035046   PMID:23081885  
PMID:23102618   PMID:23123587   PMID:23142078   PMID:23228442   PMID:23244622   PMID:23250422   PMID:23274085   PMID:23275438   PMID:23315073   PMID:23359422   PMID:23386687   PMID:23425014  
PMID:23429703   PMID:23508953   PMID:23592839   PMID:23604129   PMID:23665200   PMID:23695213   PMID:23699409   PMID:23732640   PMID:23744272   PMID:23749404   PMID:23759924   PMID:23778976  
PMID:23810393   PMID:23820898   PMID:23858058   PMID:23878245   PMID:23947572   PMID:23955302   PMID:23966835   PMID:24077282   PMID:24096482   PMID:24161930   PMID:24170201   PMID:24209762  
PMID:24227713   PMID:24532578   PMID:24591652   PMID:24627160   PMID:24632604   PMID:24737317   PMID:24740570   PMID:24874429   PMID:24931163   PMID:24952961   PMID:25043031   PMID:25155956  
PMID:25175012   PMID:25180600   PMID:25181011   PMID:25211037   PMID:25273085   PMID:25298408   PMID:25338081   PMID:25360538   PMID:25533187   PMID:25565629   PMID:25613864   PMID:25654764  
PMID:25700280   PMID:25755286   PMID:25780943   PMID:25880340   PMID:25893604   PMID:26235615   PMID:26350902   PMID:26412398   PMID:26432869   PMID:26496610   PMID:26693177   PMID:26837766  
PMID:26868506   PMID:26880751   PMID:26975583   PMID:27023784   PMID:27048565   PMID:27050589   PMID:27064374   PMID:27080031   PMID:27278252   PMID:27416896   PMID:27542907   PMID:27582005  
PMID:27593484   PMID:27760312   PMID:27768862   PMID:27863419   PMID:27889578   PMID:28013293   PMID:28041914   PMID:28069738   PMID:28092373   PMID:28289099   PMID:28484008   PMID:28512249  
PMID:28671696   PMID:28695825   PMID:28746872   PMID:28763796   PMID:28972182   PMID:29056426   PMID:29080681   PMID:29153836   PMID:29170467   PMID:29196670   PMID:29364507   PMID:29396625  
PMID:29449538   PMID:29491408   PMID:29509898   PMID:29635516   PMID:29669786   PMID:29758070   PMID:29766046   PMID:29950673   PMID:29966750   PMID:30124871   PMID:30237867   PMID:30242175  
PMID:30508035   PMID:30514904   PMID:30679017   PMID:30700906   PMID:30910408   PMID:30910807   PMID:30918308   PMID:30928642   PMID:31078684   PMID:31182472   PMID:31461347   PMID:31527310  
PMID:31978189   PMID:32023468   PMID:32133736   PMID:32191726   PMID:32303566   PMID:32579942   PMID:32588887   PMID:32705128   PMID:32796887   PMID:32807950   PMID:32912901   PMID:33159078  
PMID:33239450   PMID:33401933   PMID:33593821   PMID:33786950   PMID:34032632   PMID:34081952   PMID:34208233   PMID:34222844   PMID:34242585   PMID:34253722   PMID:34279736   PMID:34325132  
PMID:34380034   PMID:34463540   PMID:34497307   PMID:34576223   PMID:34677125   PMID:34806651   PMID:34999833   PMID:35119931   PMID:35275792   PMID:35288456   PMID:35584673   PMID:35645731  
PMID:35851298   PMID:36114006   PMID:36400753   PMID:36423280   PMID:36443301   PMID:36473049   PMID:36586433   PMID:36732866  


Genomics

Comparative Map Data
Tsc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,814,788 - 24,851,607 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,814,790 - 24,851,604 (-)EnsemblGRCm39 Ensembl
GRCm381724,595,816 - 24,632,676 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,595,816 - 24,632,630 (-)EnsemblGRCm38mm10GRCm38
MGSCv371724,732,882 - 24,769,574 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361724,323,537 - 24,360,229 (-)NCBIMGSCv36mm8
Celera1725,113,932 - 25,155,030 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.41NCBI
TSC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,047,985 - 2,089,491 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl162,047,967 - 2,089,491 (+)EnsemblGRCh38hg38GRCh38
GRCh37162,097,986 - 2,139,492 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,037,991 - 2,078,714 (+)NCBINCBI36Build 36hg18NCBI36
Build 34162,038,599 - 2,078,713NCBI
Celera162,310,097 - 2,350,826 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef162,022,255 - 2,063,441 (+)NCBIHuRef
CHM1_1162,097,965 - 2,138,628 (+)NCBICHM1_1
T2T-CHM13v2.0162,067,794 - 2,109,598 (+)NCBIT2T-CHM13v2.0
Tsc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21013,621,135 - 13,655,773 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,621,136 - 13,655,951 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1018,367,921 - 18,402,464 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01017,856,767 - 17,891,310 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01013,355,965 - 13,390,509 (-)NCBIRnor_WKY
Rnor_6.01013,962,006 - 13,996,684 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,961,947 - 13,996,584 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,778,990 - 13,813,725 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,848,210 - 13,883,189 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11013,848,241 - 13,882,689NCBI
Celera1013,301,129 - 13,335,713 (-)NCBICelera
Cytogenetic Map10q12NCBI
Tsc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544215,178,487 - 15,216,362 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544215,178,356 - 15,216,978 (-)NCBIChiLan1.0ChiLan1.0
TSC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1166,040,481 - 6,080,306 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v016615,776 - 655,411 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1162,135,696 - 2,175,569 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl162,135,696 - 2,175,569 (+)Ensemblpanpan1.1panPan2
TSC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,865,509 - 38,898,977 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,865,507 - 38,898,960 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha640,104,412 - 40,137,701 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0639,173,764 - 39,207,052 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl639,173,766 - 39,207,060 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1638,858,570 - 38,891,854 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,830,888 - 38,864,172 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,309,683 - 39,342,799 (-)NCBIUU_Cfam_GSD_1.0
Tsc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344104,716,067 - 104,751,311 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366941,958,154 - 1,993,363 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366941,958,152 - 1,993,373 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TSC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl339,898,925 - 39,937,371 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1339,898,924 - 39,935,579 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2342,245,971 - 42,282,092 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TSC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.151,946,534 - 1,985,168 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl51,946,927 - 1,987,682 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606829,078,990 - 29,119,738 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tsc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624913166,931 - 202,953 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624913166,931 - 203,008 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tsc2
1234 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:272
Count of miRNA genes:217
Interacting mature miRNAs:236
Transcripts:ENSMUST00000097373
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357902Obq19_mobesity QTL 19 (mouse)Not determined17125662076Mouse
12910982Pifs2_mpeptide-induced fatal syndrome 2 (mouse)17126189355Mouse
1357743Lith3_mlithogenic gene 3 (mouse)Not determined17126194456Mouse
1301615Cfld3_mcystic fibrosis lung disease 3 (mouse)Not determined17127081639Mouse
1300613Pcyts4_mplasmacytoma susceptibility 4 (mouse)Not determined17127081639Mouse
1302100Circp2_mcircadian photosensitivity 2 (mouse)Not determined17129198453Mouse
12910527Nrq1a_mnoise-induced hearing loss resistant QTL 1a (mouse)17129198453Mouse
12910528Nrq1_mnoise-induced hearing loss resistant QTL 1 (mouse)17129198453Mouse
13524851Asrq8_macoustic startle response 8 (mouse)17131030170Mouse
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17334817537348299Mouse
1357680Idd23_minsulin dependent diabetes susceptibility 23 (mouse)Not determined17397489026401133Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17397489048866091Mouse
1301327Lmr7_mleishmaniasis resistance 7 (mouse)Not determined17485475227715939Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined485475245670266Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17485475246469702Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17485475247885665Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined485475265637357Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17689393640893936Mouse
4141608Phl1_mprogressive hearing loss 1 (mouse)Not determined17787584329487423Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17858491442585149Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17858491442585149Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171087811944878219Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1120648439364059Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1188597145886119Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171199818445998184Mouse
4142507Obrq13_mobesity resistance QTL 13 (mouse)Not determined1219832925076769Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171245178746451787Mouse
1558807Ceat1_mchronic experimental autoimmune thyroiditis 1 (mouse)Not determined171263668226401133Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171264696146646961Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171412337248123496Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171506165249061760Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171506165249061760Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171506165249061760Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171506165249061760Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171681972150819843Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171681972150819843Mouse
1302038Radpf1_mradiation pulmonary fibrosis 1 (mouse)Not determined171683545533819843Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171702994351030078Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171746220851462345Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171746220851462345Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171746220851462345Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171746220851462345Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171817541252178214Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171841835752420983Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171842214152424327Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171914502553145025Mouse
12910769Rtmq1_mrenal tumor modifier QTL 1 (mouse)172290003625721472Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172461275058612864Mouse

Markers in Region
Tsc2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371724,733,532 - 24,733,836UniSTSGRCm37
Celera1725,114,582 - 25,114,886UniSTS
Cytogenetic Map17A3.3UniSTS
cM Map1710.3UniSTS
Pkd1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381724,595,694 - 24,595,804UniSTSGRCm38
MGSCv371724,732,639 - 24,732,749UniSTSGRCm37
Celera1725,113,689 - 25,113,799UniSTS
Cytogenetic Map17A3.3UniSTS
Tsc2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17A3.3UniSTS
Tsc2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381724,596,587 - 24,596,891UniSTSGRCm38
MGSCv371724,733,532 - 24,733,836UniSTSGRCm37
Celera1725,114,582 - 25,114,886UniSTS
Cytogenetic Map17A3.3UniSTS
Tsc2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17A3.3UniSTS
Tsc2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17A3.3UniSTS
Tsc2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17A3.3UniSTS
Tsc2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17A3.3UniSTS
Tsc2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17A3.3UniSTS
cM Map1710.3UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001039363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001286713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001286714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001286716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001286718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001286720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_175374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017317384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017317386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017317390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017317393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030249646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030249647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030249648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030249650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036160475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003952103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004939509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB009371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC132367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF132986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF333927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK220072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC052207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC052449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY742714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U37775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U38921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U39818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000097373   ⟹   ENSMUSP00000094986
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,814,911 - 24,851,603 (-)Ensembl
GRCm38.p6 Ensembl1724,595,937 - 24,632,629 (-)Ensembl
RefSeq Acc Id: ENSMUST00000226242
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,826,689 - 24,833,555 (-)Ensembl
GRCm38.p6 Ensembl1724,607,715 - 24,614,581 (-)Ensembl
RefSeq Acc Id: ENSMUST00000226284   ⟹   ENSMUSP00000153869
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,814,790 - 24,851,601 (-)Ensembl
GRCm38.p6 Ensembl1724,595,816 - 24,632,627 (-)Ensembl
RefSeq Acc Id: ENSMUST00000226309
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,824,836 - 24,825,512 (-)Ensembl
GRCm38.p6 Ensembl1724,605,862 - 24,606,538 (-)Ensembl
RefSeq Acc Id: ENSMUST00000226398   ⟹   ENSMUSP00000153792
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,815,444 - 24,851,582 (-)Ensembl
GRCm38.p6 Ensembl1724,596,470 - 24,632,608 (-)Ensembl
RefSeq Acc Id: ENSMUST00000226428
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,822,242 - 24,825,517 (-)Ensembl
GRCm38.p6 Ensembl1724,603,268 - 24,606,543 (-)Ensembl
RefSeq Acc Id: ENSMUST00000226473
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,815,854 - 24,816,223 (-)Ensembl
GRCm38.p6 Ensembl1724,596,880 - 24,597,249 (-)Ensembl
RefSeq Acc Id: ENSMUST00000226691
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,816,020 - 24,818,056 (-)Ensembl
GRCm38.p6 Ensembl1724,597,046 - 24,599,082 (-)Ensembl
RefSeq Acc Id: ENSMUST00000226985
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,823,826 - 24,824,524 (-)Ensembl
GRCm38.p6 Ensembl1724,604,852 - 24,605,550 (-)Ensembl
RefSeq Acc Id: ENSMUST00000227094
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,815,488 - 24,816,029 (-)Ensembl
GRCm38.p6 Ensembl1724,596,514 - 24,597,055 (-)Ensembl
RefSeq Acc Id: ENSMUST00000227330
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,821,259 - 24,823,129 (-)Ensembl
GRCm38.p6 Ensembl1724,602,285 - 24,604,155 (-)Ensembl
RefSeq Acc Id: ENSMUST00000227432
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,815,463 - 24,816,032 (-)Ensembl
GRCm38.p6 Ensembl1724,596,489 - 24,597,058 (-)Ensembl
RefSeq Acc Id: ENSMUST00000227509   ⟹   ENSMUSP00000154493
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,851,034 - 24,851,567 (-)Ensembl
GRCm38.p6 Ensembl1724,632,060 - 24,632,593 (-)Ensembl
RefSeq Acc Id: ENSMUST00000227543
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,825,346 - 24,828,105 (-)Ensembl
GRCm38.p6 Ensembl1724,606,372 - 24,609,131 (-)Ensembl
RefSeq Acc Id: ENSMUST00000227607   ⟹   ENSMUSP00000153758
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,818,584 - 24,851,549 (-)Ensembl
GRCm38.p6 Ensembl1724,599,610 - 24,632,575 (-)Ensembl
RefSeq Acc Id: ENSMUST00000227658   ⟹   ENSMUSP00000153770
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,823,617 - 24,826,742 (-)Ensembl
GRCm38.p6 Ensembl1724,604,643 - 24,607,768 (-)Ensembl
RefSeq Acc Id: ENSMUST00000227745   ⟹   ENSMUSP00000154338
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,815,495 - 24,851,569 (-)Ensembl
GRCm38.p6 Ensembl1724,596,521 - 24,632,595 (-)Ensembl
RefSeq Acc Id: ENSMUST00000227754
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,831,601 - 24,851,576 (-)Ensembl
GRCm38.p6 Ensembl1724,612,627 - 24,632,602 (-)Ensembl
RefSeq Acc Id: ENSMUST00000227804   ⟹   ENSMUSP00000153864
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,815,495 - 24,817,281 (-)Ensembl
GRCm38.p6 Ensembl1724,596,521 - 24,598,307 (-)Ensembl
RefSeq Acc Id: ENSMUST00000228220
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,827,934 - 24,829,612 (-)Ensembl
GRCm38.p6 Ensembl1724,608,960 - 24,610,638 (-)Ensembl
RefSeq Acc Id: ENSMUST00000228412   ⟹   ENSMUSP00000154706
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,815,495 - 24,851,604 (-)Ensembl
GRCm38.p6 Ensembl1724,596,521 - 24,632,630 (-)Ensembl
RefSeq Acc Id: ENSMUST00000228729
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,823,621 - 24,825,484 (-)Ensembl
GRCm38.p6 Ensembl1724,604,647 - 24,606,510 (-)Ensembl
RefSeq Acc Id: NM_001039363   ⟹   NP_001034452
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,814,788 - 24,851,594 (-)NCBI
GRCm381724,595,816 - 24,632,627 (-)NCBI
MGSCv371724,732,882 - 24,769,574 (-)RGD
Celera1725,113,811 - 25,155,028 (-)NCBI
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001286713   ⟹   NP_001273642
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,814,788 - 24,851,594 (-)NCBI
GRCm381724,595,816 - 24,632,627 (-)NCBI
Celera1725,113,811 - 25,155,028 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001286714   ⟹   NP_001273643
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,814,788 - 24,851,594 (-)NCBI
GRCm381724,595,816 - 24,632,627 (-)NCBI
Celera1725,113,811 - 25,155,028 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001286716   ⟹   NP_001273645
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,814,788 - 24,851,594 (-)NCBI
GRCm381724,595,816 - 24,632,627 (-)NCBI
Celera1725,113,811 - 25,155,028 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001286718   ⟹   NP_001273647
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,814,788 - 24,851,594 (-)NCBI
GRCm381724,595,816 - 24,632,627 (-)NCBI
Celera1725,113,811 - 25,155,028 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001286720   ⟹   NP_001273649
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,814,788 - 24,851,594 (-)NCBI
GRCm381724,595,816 - 24,632,627 (-)NCBI
Celera1725,113,811 - 25,155,028 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001403402   ⟹   NP_001390331
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,814,788 - 24,851,594 (-)NCBI
RefSeq Acc Id: NM_001403403   ⟹   NP_001390332
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,814,788 - 24,851,594 (-)NCBI
RefSeq Acc Id: NM_001403404   ⟹   NP_001390333
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,814,788 - 24,851,594 (-)NCBI
RefSeq Acc Id: NM_001403405   ⟹   NP_001390334
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,814,788 - 24,851,594 (-)NCBI
RefSeq Acc Id: NM_001403406   ⟹   NP_001390335
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,814,788 - 24,851,594 (-)NCBI
RefSeq Acc Id: NM_001403407   ⟹   NP_001390336
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,814,788 - 24,851,594 (-)NCBI
RefSeq Acc Id: NM_001403408   ⟹   NP_001390337
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,814,788 - 24,851,594 (-)NCBI
RefSeq Acc Id: NM_001403409   ⟹   NP_001390338
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,814,788 - 24,851,594 (-)NCBI
RefSeq Acc Id: NM_001403410   ⟹   NP_001390339
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,814,788 - 24,851,594 (-)NCBI
RefSeq Acc Id: NM_001403411   ⟹   NP_001390340
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,814,788 - 24,851,594 (-)NCBI
RefSeq Acc Id: NM_001403412   ⟹   NP_001390341
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,814,788 - 24,851,594 (-)NCBI
RefSeq Acc Id: NM_001403413   ⟹   NP_001390342
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,814,788 - 24,851,594 (-)NCBI
RefSeq Acc Id: NM_001403414   ⟹   NP_001390343
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,814,788 - 24,851,594 (-)NCBI
RefSeq Acc Id: NM_001403415   ⟹   NP_001390344
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,814,788 - 24,851,594 (-)NCBI
RefSeq Acc Id: NM_001403416   ⟹   NP_001390345
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,814,788 - 24,851,594 (-)NCBI
RefSeq Acc Id: NM_001403417   ⟹   NP_001390346
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,814,788 - 24,851,594 (-)NCBI
RefSeq Acc Id: NM_001403418   ⟹   NP_001390347
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,814,788 - 24,851,594 (-)NCBI
RefSeq Acc Id: NM_011647   ⟹   NP_035777
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,814,788 - 24,851,594 (-)NCBI
GRCm381724,595,816 - 24,632,627 (-)NCBI
MGSCv371724,732,882 - 24,769,574 (-)RGD
Celera1725,113,811 - 25,155,028 (-)NCBI
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_175374
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,814,788 - 24,851,594 (-)NCBI
RefSeq Acc Id: XM_017317384   ⟹   XP_017172873
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,815,455 - 24,851,599 (-)NCBI
GRCm381724,596,481 - 24,632,633 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017317386   ⟹   XP_017172875
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,815,455 - 24,851,607 (-)NCBI
GRCm381724,596,481 - 24,632,633 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017317390   ⟹   XP_017172879
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,815,455 - 24,851,594 (-)NCBI
GRCm381724,596,481 - 24,632,620 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017317393   ⟹   XP_017172882
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,815,455 - 24,851,599 (-)NCBI
GRCm381724,596,481 - 24,632,625 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030249646   ⟹   XP_030105506
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,815,455 - 24,851,594 (-)NCBI
GRCm381724,596,481 - 24,632,633 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030249647   ⟹   XP_030105507
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,815,455 - 24,851,596 (-)NCBI
GRCm381724,596,481 - 24,632,632 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030249648   ⟹   XP_030105508
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,815,455 - 24,851,589 (-)NCBI
GRCm381724,596,481 - 24,632,615 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030249650   ⟹   XP_030105510
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,815,455 - 24,851,591 (-)NCBI
GRCm381724,596,481 - 24,632,626 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036160475   ⟹   XP_036016368
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,815,455 - 24,851,595 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003952103
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,815,464 - 24,851,607 (-)NCBI
GRCm381724,596,490 - 24,632,676 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004939509
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,815,464 - 24,851,607 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001034452 (Get FASTA)   NCBI Sequence Viewer  
  NP_001273642 (Get FASTA)   NCBI Sequence Viewer  
  NP_001273643 (Get FASTA)   NCBI Sequence Viewer  
  NP_001273645 (Get FASTA)   NCBI Sequence Viewer  
  NP_001273647 (Get FASTA)   NCBI Sequence Viewer  
  NP_001273649 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390331 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390332 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390333 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390334 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390335 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390336 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390337 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390338 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390339 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390340 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390341 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390342 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390343 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390344 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390345 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390346 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390347 (Get FASTA)   NCBI Sequence Viewer  
  NP_035777 (Get FASTA)   NCBI Sequence Viewer  
  XP_017172873 (Get FASTA)   NCBI Sequence Viewer  
  XP_017172875 (Get FASTA)   NCBI Sequence Viewer  
  XP_017172879 (Get FASTA)   NCBI Sequence Viewer  
  XP_017172882 (Get FASTA)   NCBI Sequence Viewer  
  XP_030105506 (Get FASTA)   NCBI Sequence Viewer  
  XP_030105507 (Get FASTA)   NCBI Sequence Viewer  
  XP_030105508 (Get FASTA)   NCBI Sequence Viewer  
  XP_030105510 (Get FASTA)   NCBI Sequence Viewer  
  XP_036016368 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA86901 (Get FASTA)   NCBI Sequence Viewer  
  AAA86902 (Get FASTA)   NCBI Sequence Viewer  
  AAB18754 (Get FASTA)   NCBI Sequence Viewer  
  AAD27867 (Get FASTA)   NCBI Sequence Viewer  
  AAH52449 (Get FASTA)   NCBI Sequence Viewer  
  AAH60701 (Get FASTA)   NCBI Sequence Viewer  
  AAK48834 (Get FASTA)   NCBI Sequence Viewer  
  BAA28845 (Get FASTA)   NCBI Sequence Viewer  
  BAE27610 (Get FASTA)   NCBI Sequence Viewer  
  BAE27945 (Get FASTA)   NCBI Sequence Viewer  
  BAE28220 (Get FASTA)   NCBI Sequence Viewer  
  BAE28321 (Get FASTA)   NCBI Sequence Viewer  
  BAE28325 (Get FASTA)   NCBI Sequence Viewer  
  BAE37575 (Get FASTA)   NCBI Sequence Viewer  
  BAE37839 (Get FASTA)   NCBI Sequence Viewer  
  BAE41898 (Get FASTA)   NCBI Sequence Viewer  
  BAE42178 (Get FASTA)   NCBI Sequence Viewer  
  EDL22341 (Get FASTA)   NCBI Sequence Viewer  
  EDL22342 (Get FASTA)   NCBI Sequence Viewer  
  EDL22343 (Get FASTA)   NCBI Sequence Viewer  
  EDL22344 (Get FASTA)   NCBI Sequence Viewer  
  EDL22345 (Get FASTA)   NCBI Sequence Viewer  
  Q61037 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001034452   ⟸   NM_001039363
- Peptide Label: isoform 2
- UniProtKB: Q3UGI8 (UniProtKB/TrEMBL),   Q7TT21 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_035777   ⟸   NM_011647
- Peptide Label: isoform 1
- UniProtKB: Q3UGI8 (UniProtKB/TrEMBL),   A0A2I3BPP1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001273645   ⟸   NM_001286716
- Peptide Label: isoform 2
- UniProtKB: Q3UGI8 (UniProtKB/TrEMBL),   Q7TT21 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001273643   ⟸   NM_001286714
- Peptide Label: isoform 1
- UniProtKB: Q3UG88 (UniProtKB/TrEMBL),   Q3UGI8 (UniProtKB/TrEMBL),   Q7TT21 (UniProtKB/TrEMBL),   A0A2I3BPP1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001273647   ⟸   NM_001286718
- Peptide Label: isoform 4
- UniProtKB: Q7TT21 (UniProtKB/TrEMBL),   A0A2I3BRT5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001273649   ⟸   NM_001286720
- Peptide Label: isoform 5
- UniProtKB: Q3TQ10 (UniProtKB/TrEMBL),   Q3UGI8 (UniProtKB/TrEMBL),   Q3UHB2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001273642   ⟸   NM_001286713
- Peptide Label: isoform 3
- UniProtKB: Q3UGI8 (UniProtKB/TrEMBL),   Q3UHB2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017172875   ⟸   XM_017317386
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017172873   ⟸   XM_017317384
- Peptide Label: isoform X19
- UniProtKB: Q3UHB2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017172879   ⟸   XM_017317390
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_017172882   ⟸   XM_017317393
- Peptide Label: isoform X16
- Sequence:
RefSeq Acc Id: XP_030105506   ⟸   XM_030249646
- Peptide Label: isoform X2
RefSeq Acc Id: XP_030105507   ⟸   XM_030249647
- Peptide Label: isoform X10
RefSeq Acc Id: XP_030105510   ⟸   XM_030249650
- Peptide Label: isoform X11
RefSeq Acc Id: XP_030105508   ⟸   XM_030249648
- Peptide Label: isoform X10
RefSeq Acc Id: ENSMUSP00000153770   ⟸   ENSMUST00000227658
RefSeq Acc Id: ENSMUSP00000154493   ⟸   ENSMUST00000227509
RefSeq Acc Id: ENSMUSP00000153758   ⟸   ENSMUST00000227607
RefSeq Acc Id: ENSMUSP00000154338   ⟸   ENSMUST00000227745
RefSeq Acc Id: ENSMUSP00000153864   ⟸   ENSMUST00000227804
RefSeq Acc Id: ENSMUSP00000153792   ⟸   ENSMUST00000226398
RefSeq Acc Id: ENSMUSP00000153869   ⟸   ENSMUST00000226284
RefSeq Acc Id: ENSMUSP00000094986   ⟸   ENSMUST00000097373
RefSeq Acc Id: ENSMUSP00000154706   ⟸   ENSMUST00000228412
RefSeq Acc Id: XP_036016368   ⟸   XM_036160475
- Peptide Label: isoform X3
RefSeq Acc Id: NP_001390336   ⟸   NM_001403407
- Peptide Label: isoform 14
RefSeq Acc Id: NP_001390334   ⟸   NM_001403405
- Peptide Label: isoform 16
RefSeq Acc Id: NP_001390335   ⟸   NM_001403406
- Peptide Label: isoform 15
RefSeq Acc Id: NP_001390332   ⟸   NM_001403403
- Peptide Label: isoform 17
RefSeq Acc Id: NP_001390337   ⟸   NM_001403408
- Peptide Label: isoform 13
RefSeq Acc Id: NP_001390345   ⟸   NM_001403416
- Peptide Label: isoform 7
RefSeq Acc Id: NP_001390338   ⟸   NM_001403409
- Peptide Label: isoform 12
RefSeq Acc Id: NP_001390346   ⟸   NM_001403417
- Peptide Label: isoform 4
RefSeq Acc Id: NP_001390339   ⟸   NM_001403410
- Peptide Label: isoform 11
RefSeq Acc Id: NP_001390342   ⟸   NM_001403413
- Peptide Label: isoform 9
RefSeq Acc Id: NP_001390347   ⟸   NM_001403418
- Peptide Label: isoform 6
RefSeq Acc Id: NP_001390340   ⟸   NM_001403411
- Peptide Label: isoform 11
RefSeq Acc Id: NP_001390341   ⟸   NM_001403412
- Peptide Label: isoform 10
RefSeq Acc Id: NP_001390343   ⟸   NM_001403414
- Peptide Label: isoform 6
RefSeq Acc Id: NP_001390344   ⟸   NM_001403415
- Peptide Label: isoform 8
RefSeq Acc Id: NP_001390331   ⟸   NM_001403402
- Peptide Label: isoform 16
RefSeq Acc Id: NP_001390333   ⟸   NM_001403404
- Peptide Label: isoform 17
Protein Domains
Rap-GAP   Tuberin N-terminal   Tuberin-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61037-F1-model_v2 AlphaFold Q61037 1-1814 view protein structure

Promoters
RGD ID:13675044
Promoter ID:EPDNEW_M21670
Type:initiation region
Name:Tsc2_1
Description:Mus musculus tuberous sclerosis 2 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381724,632,618 - 24,632,678EPDNEW
RGD ID:6828834
Promoter ID:MM_KWN:22529
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:UC008AXF.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361724,733,821 - 24,734,917 (-)MPROMDB
RGD ID:6828831
Promoter ID:MM_KWN:22530
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   BoneMarrow_0Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:UC008AWX.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361724,735,271 - 24,736,257 (-)MPROMDB
RGD ID:6848702
Promoter ID:MM_TRO:4250
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   Brain,   Kidney,   Lung,   MEF_B4
Transcripts:MTR039229.17.566.8
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361724,737,171 - 24,737,671 (-)MPROMDB
RGD ID:6847474
Promoter ID:MM_ACW:22044
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour,   Kidney
Transcripts:TSC2.SSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361724,738,214 - 24,738,714 (-)MPROMDB
RGD ID:6828838
Promoter ID:MM_KWN:22531
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000088420,   ENSMUST00000097374,   ENSMUST00000115290,   ENSMUST00000115291,   ENSMUST00000115292,   ENSMUST00000115294,   NM_001039363,   NM_008743,   NM_011647,   UC008AWY.1,   UC008AXC.1,   UC008AXD.1,   UC008AXE.1,   UC008AXG.1,   UC008AXH.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361724,769,491 - 24,770,147 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:102548 AgrOrtholog
Ensembl Genes ENSMUSG00000002496 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000094986 ENTREZGENE
  ENSMUSP00000094986.2 UniProtKB/TrEMBL
  ENSMUSP00000153758 ENTREZGENE
  ENSMUSP00000153758.2 UniProtKB/TrEMBL
  ENSMUSP00000153770.2 UniProtKB/TrEMBL
  ENSMUSP00000153792 ENTREZGENE
  ENSMUSP00000153792.2 UniProtKB/TrEMBL
  ENSMUSP00000153864.2 UniProtKB/TrEMBL
  ENSMUSP00000153869 ENTREZGENE
  ENSMUSP00000153869.2 UniProtKB/TrEMBL
  ENSMUSP00000154338 ENTREZGENE
  ENSMUSP00000154338.2 UniProtKB/TrEMBL
  ENSMUSP00000154493.2 UniProtKB/TrEMBL
  ENSMUSP00000154706 ENTREZGENE
  ENSMUSP00000154706.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000097373 ENTREZGENE
  ENSMUST00000097373.2 UniProtKB/TrEMBL
  ENSMUST00000226284 ENTREZGENE
  ENSMUST00000226284.2 UniProtKB/TrEMBL
  ENSMUST00000226398 ENTREZGENE
  ENSMUST00000226398.2 UniProtKB/TrEMBL
  ENSMUST00000227509.2 UniProtKB/TrEMBL
  ENSMUST00000227607 ENTREZGENE
  ENSMUST00000227607.2 UniProtKB/TrEMBL
  ENSMUST00000227658.2 UniProtKB/TrEMBL
  ENSMUST00000227745 ENTREZGENE
  ENSMUST00000227745.2 UniProtKB/TrEMBL
  ENSMUST00000227804.2 UniProtKB/TrEMBL
  ENSMUST00000228412 ENTREZGENE
  ENSMUST00000228412.2 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
  3.40.50.11210 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rap/Ran-GAP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rap_GAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tuberin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tuberin-type_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tuberin/Ral-act_asu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tuberin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22084 UniProtKB/TrEMBL
MGD MGI:102548 ENTREZGENE
NCBI Gene 22084 ENTREZGENE
PANTHER PTHR10063 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TUBERIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF3384 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rap_GAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tuberin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tsc2 PhenoGen
PRINTS TUBERIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RAPGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF111347 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2I3BPE9_MOUSE UniProtKB/TrEMBL
  A0A2I3BPP1 ENTREZGENE, UniProtKB/TrEMBL
  A0A2I3BPR7_MOUSE UniProtKB/TrEMBL
  A0A2I3BRA1_MOUSE UniProtKB/TrEMBL
  A0A2I3BRT5 ENTREZGENE, UniProtKB/TrEMBL
  Q3TBX9_MOUSE UniProtKB/TrEMBL
  Q3TCQ7_MOUSE UniProtKB/TrEMBL
  Q3TP98_MOUSE UniProtKB/TrEMBL
  Q3TQ10 ENTREZGENE, UniProtKB/TrEMBL
  Q3UG84_MOUSE UniProtKB/TrEMBL
  Q3UG88 ENTREZGENE, UniProtKB/TrEMBL
  Q3UGI8 ENTREZGENE, UniProtKB/TrEMBL
  Q3UHB2 ENTREZGENE, UniProtKB/TrEMBL
  Q3UI96_MOUSE UniProtKB/TrEMBL
  Q61037 ENTREZGENE
  Q7TT21 ENTREZGENE, UniProtKB/TrEMBL
  TSC2_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary P97723 UniProtKB/Swiss-Prot
  P97724 UniProtKB/Swiss-Prot
  P97725 UniProtKB/Swiss-Prot
  P97727 UniProtKB/Swiss-Prot
  Q61007 UniProtKB/Swiss-Prot
  Q61008 UniProtKB/Swiss-Prot
  Q9WUF6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-05-07 Tsc2  TSC complex subunit 2  Tsc2  tuberous sclerosis 2  Symbol and/or name change 5135510 APPROVED