Thra (thyroid hormone receptor alpha) - Rat Genome Database

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Gene: Thra (thyroid hormone receptor alpha) Mus musculus
Analyze
Symbol: Thra
Name: thyroid hormone receptor alpha
RGD ID: 11415
MGI Page MGI
Description: Enables chromatin DNA binding activity; nuclear receptor activity; and transcription cis-regulatory region binding activity. Involved in mRNA transcription by RNA polymerase II; positive regulation of metabolic process; and positive regulation of thyroid hormone receptor signaling pathway. Acts upstream of or within several processes, including cartilage condensation; female mating behavior; and type I pneumocyte differentiation. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Used to study thyroid hormone resistance syndrome. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 6 and renal cell carcinoma. Orthologous to human THRA (thyroid hormone receptor alpha).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 6430529J03Rik; AW259572; c-erb; c-erbA-1; c-erbA-alpha; c-erbAalpha; Er; Erba; Nr; Nr1a1; nuclear receptor subfamily 1 group A member 1; Rvr; T3R; T3R[; T3R[a]; T3Ralpha; Thr; Thra1; Thra2; TR alpha 1; TR alpha 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,631,539 - 98,659,832 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,631,464 - 98,659,832 (+)EnsemblGRCm39 Ensembl
GRCm381198,740,776 - 98,769,006 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,740,638 - 98,769,006 (+)EnsemblGRCm38mm10GRCm38
MGSCv371198,603,187 - 98,626,425 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361198,557,963 - 98,581,201 (+)NCBIMGSCv36mm8
Celera11108,407,991 - 108,419,811 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1162.58NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (EXP)
(2,4,5-trichlorophenoxy)acetic acid  (EXP)
(E)-thiamethoxam  (ISO)
(R)-lipoic acid  (EXP)
(S)-colchicine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-Hydroxypyrene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,5-trichlorophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-[(2,4-dichlorophenyl)methyl]-4-(2,4,4-trimethylpentan-2-yl)phenol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (ISO)
3,3',5'-triiodo-L-thyronine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5,5'-tetraiodothyroacetic acid  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-iodoprop-2-yn-1-yl butylcarbamate  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (EXP)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (EXP)
9-phenanthrol  (ISO)
actinomycin D  (EXP)
adefovir pivoxil  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP,ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amsacrine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (ISO)
apigenin  (ISO)
aprepitant  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bexarotene  (ISO)
bezafibrate  (ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Bisphenol Z  (ISO)
bithionol  (ISO)
bortezomib  (ISO)
bromobenzene  (ISO)
buta-1,3-diene  (EXP)
butanal  (ISO)
calciol  (ISO)
camptothecin  (ISO)
carbon nanotube  (EXP)
casticin  (EXP)
CGP 52608  (ISO)
chlordecone  (EXP)
Chlorobenzilate  (ISO)
chloroprene  (EXP,ISO)
chloroquine  (ISO)
chlorpyrifos  (EXP)
chlorpyrifos-methyl  (ISO)
chromium(6+)  (EXP)
chrysin  (ISO)
ciglitazone  (ISO)
clomiphene  (ISO)
clomipramine  (ISO)
closantel  (ISO)
clozapine  (ISO)
cocaine  (EXP)
copper(II) sulfate  (EXP,ISO)
coumarin  (ISO)
crocidolite asbestos  (EXP)
daidzein  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP,ISO)
dexamethasone  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diethyl hydrogen phosphate  (ISO)
diethylstilbestrol  (EXP)
digitoxin  (ISO)
diiodine  (EXP)
diniconazole  (ISO)
disulfiram  (ISO)
domperidone  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
dronedarone  (ISO)
elemental selenium  (EXP)
emetine  (ISO)
endosulfan  (ISO)
enilconazole  (ISO)
epoxiconazole  (EXP)
equilin  (ISO)
estriol  (EXP)
ethanol  (EXP)
Ethylenethiourea  (EXP)
fenarimol  (ISO)
fenitrothion  (ISO)
fenpyroximate  (ISO)
fenvalerate  (EXP,ISO)
fipronil  (ISO)
flavonoids  (ISO)
fludioxonil  (ISO)
Flumetralin  (ISO)
flutamide  (ISO)
folic acid  (EXP)
FR900359  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glyphosate  (ISO)
haloperidol  (ISO)
hydroxyflutamide  (ISO)
indometacin  (ISO)
iprodione  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
lead(0)  (ISO)
linuron  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP)
mebendazole  (ISO)
menadione  (ISO)
methamphetamine  (ISO)
methimazole  (ISO)
methylmercury chloride  (EXP)
microcystin-LR  (EXP)
mifepristone  (ISO)
mycophenolic acid  (ISO)
N-benzoyl-L-alanine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
napropamide  (ISO)
nebivolol  (ISO)
nickel atom  (ISO)
nitrofen  (ISO)
Nonylphenol  (ISO)
norethisterone  (ISO)
ozone  (EXP,ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pazopanib  (ISO)
PCB138  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phoxim  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanil  (ISO)
propylparaben  (ISO)
pyridaben  (ISO)
quercetin  (EXP)
rac-lactic acid  (ISO)
resveratrol  (EXP)
rotenone  (ISO)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
staurosporine  (ISO)
sulfadimethoxine  (ISO)
sulfasalazine  (EXP)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
tegaserod  (ISO)
telithromycin  (ISO)
Temsirolimus  (ISO)
teniposide  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (EXP,ISO)
thiamethoxam  (ISO)
thiazolidinediones  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
thyroxine  (ISO)
tiratricol  (EXP,ISO)
titanium dioxide  (EXP)
tributylstannane  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
triptonide  (EXP)
troglitazone  (EXP,ISO)
tungsten  (EXP)
valinomycin  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
animal organ morphogenesis  (IMP)
cartilage condensation  (IMP)
cell differentiation  (IBA)
digestive tract development  (ISO)
embryonic organ development  (ISO)
erythrocyte differentiation  (IMP)
female courtship behavior  (IMP)
hormone-mediated signaling pathway  (IEA,ISO)
intracellular receptor signaling pathway  (IEA)
kidney development  (ISO)
learning or memory  (IMP)
liver development  (ISO)
lung development  (ISO)
mRNA transcription by RNA polymerase II  (IDA,ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of DNA-templated transcription  (IDA,ISO)
negative regulation of DNA-templated transcription initiation  (ISO)
negative regulation of RNA polymerase II transcription preinitiation complex assembly  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IBA)
ossification  (IMP)
positive regulation of canonical Wnt signaling pathway  (IC)
positive regulation of cold-induced thermogenesis  (IMP)
positive regulation of female receptivity  (IMP)
positive regulation of thyroid hormone receptor signaling pathway  (IDA,ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IDA,IMP,ISO)
regulation of heart contraction  (IMP)
regulation of lipid catabolic process  (IMP)
regulation of myeloid cell apoptotic process  (IMP)
regulation of thyroid hormone receptor signaling pathway  (IMP)
regulation of transcription by RNA polymerase II  (ISO)
response to cold  (IMP)
response to nutrient levels  (ISO)
response to xenobiotic stimulus  (ISO)
retinoic acid receptor signaling pathway  (IBA)
thyroid gland development  (IGI)
thyroid hormone receptor signaling pathway  (IBA)
transcription by RNA polymerase II  (IEA,ISO)
type I pneumocyte differentiation  (IGI)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal auditory brainstem response  (IAGP)
abnormal bone mineral content  (IAGP)
abnormal bone mineralization  (IAGP)
abnormal bone remodeling  (IAGP)
abnormal bone strength  (IAGP)
abnormal bone structure  (IAGP)
abnormal cerebellum external granule cell layer morphology  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal chondrocyte physiology  (IAGP)
abnormal cochlear inner hair cell physiology  (IAGP)
abnormal cochlear outer hair cell morphology  (IAGP)
abnormal cochlear outer hair cell physiology  (IAGP)
abnormal compact bone morphology  (IAGP)
abnormal contextual conditioning behavior  (IEA)
abnormal defecation  (IAGP)
abnormal enterocyte morphology  (IAGP)
abnormal enterocyte physiology  (IAGP)
abnormal enterocyte proliferation  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal heart left ventricle morphology  (IEA)
abnormal heart rate  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal hormone level  (IAGP)
abnormal insulin secretion  (IAGP)
abnormal intestinal goblet cell morphology  (IAGP)
abnormal intestinal mucosa morphology  (IAGP)
abnormal joint morphology  (IAGP)
abnormal locomotor coordination  (IAGP)
abnormal long bone diaphysis morphology  (IAGP)
abnormal long bone epiphyseal ossification zone morphology  (IAGP)
abnormal long bone epiphyseal plate morphology  (IAGP)
abnormal long bone epiphyseal plate proliferative zone  (IAGP)
abnormal long bone metaphysis morphology  (IAGP)
abnormal mitochondrial ATP synthesis coupled electron transport  (IAGP)
abnormal object recognition memory  (IAGP)
abnormal organ of Corti morphology  (IAGP)
abnormal osteoclast physiology  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
abnormal pillar cell morphology  (IAGP)
abnormal pituitary hormone level  (IAGP)
abnormal postnatal growth  (IAGP)
abnormal pup retrieval  (IAGP)
abnormal Purkinje cell dendrite morphology  (IAGP)
abnormal response/metabolism to endogenous compounds  (IAGP)
abnormal retina inner nuclear layer morphology  (IEA)
abnormal small intestine morphology  (IAGP)
abnormal sperm motility  (IAGP)
abnormal tectorial membrane morphology  (IAGP)
abnormal tectorial membrane striated-sheet matrix morphology  (IAGP)
abnormal thyroid follicle morphology  (IAGP)
abnormal thyroid gland physiology  (IAGP)
abnormal thyroid hormone level  (IAGP)
abnormal thyroid-stimulating hormone level  (IAGP)
abnormal trabecular bone morphology  (IAGP)
ataxia  (IAGP)
decreased activity of thyroid gland  (IAGP)
decreased areal bone mineral density  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body temperature  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral content  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone resorption  (IAGP)
decreased cardiac muscle cell glucose uptake  (IAGP)
decreased circulating insulin-like growth factor I level  (IAGP)
decreased circulating thyroid-stimulating hormone level  (IAGP)
decreased circulating thyroxine level  (IAGP)
decreased circulating triiodothyronine level  (IAGP)
decreased cochlear outer hair cell electromotility  (IAGP)
decreased compact bone area  (IAGP)
decreased compact bone thickness  (IAGP)
decreased core body temperature  (IAGP)
decreased endocochlear potential  (IAGP)
decreased exploration in new environment  (IEA)
decreased follicle stimulating hormone level  (IAGP)
decreased food intake  (IAGP)
decreased grip strength  (IEA)
decreased growth hormone level  (IAGP)
decreased heart rate  (IAGP)
decreased heart ventricle muscle contractility  (IAGP)
decreased hemoglobin content  (IAGP)
decreased length of long bones  (IAGP)
decreased litter size  (IAGP)
decreased liver weight  (IAGP)
decreased luteinizing hormone level  (IAGP)
decreased mean systemic arterial blood pressure  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased prolactin level  (IAGP)
decreased small intestinal villus height  (IAGP)
decreased small intestinal villus size  (IAGP)
decreased small intestine length  (IAGP)
decreased spleen weight  (IAGP)
decreased startle reflex  (IEA)
decreased testis weight  (IAGP)
decreased total body fat amount  (IEA)
decreased total retina thickness  (IEA)
decreased trabecular bone thickness  (IAGP)
decreased width of hypertrophic chondrocyte zone  (IAGP)
delayed bone ossification  (IAGP)
delayed cranial suture closure  (IAGP)
delayed endochondral bone ossification  (IAGP)
delayed eyelid opening  (IAGP)
delayed hair appearance  (IAGP)
delayed inner ear development  (IAGP)
delayed intestine development  (IAGP)
delayed intramembranous bone ossification  (IAGP)
delayed skeletal maturation  (IAGP)
disproportionate dwarf  (IAGP)
enlarged tectorial membrane  (IAGP)
female infertility  (IAGP)
hyperactivity  (IEA)
impaired adaptive thermogenesis  (IAGP)
impaired glucose tolerance  (IAGP)
impaired lipolysis  (IAGP)
improved glucose tolerance  (IEA)
increased activity of thyroid gland  (IAGP)
increased anxiety-related response  (IAGP)
increased blood urea nitrogen level  (IEA)
increased body temperature  (IAGP)
increased body weight  (IAGP)
increased bone mass  (IAGP)
increased bone mineral content  (IAGP)
increased bone mineral density  (IEA)
increased bone trabecula number  (IAGP)
increased circulating alkaline phosphatase level  (IEA)
increased circulating creatinine level  (IEA)
increased circulating glucagon level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating leptin level  (IAGP)
increased circulating thyroid-stimulating hormone level  (IAGP)
increased circulating thyroxine level  (IAGP)
increased circulating triiodothyronine level  (IAGP)
increased compact bone thickness  (IAGP)
increased compact bone volume  (IAGP)
increased diameter of long bones  (IAGP)
increased epididymal fat pad weight  (IAGP)
increased glucagon secretion  (IAGP)
increased heart rate  (IAGP)
increased hematocrit  (IEA)
increased insulin secretion  (IAGP)
increased insulin sensitivity  (IAGP)
increased long bone epiphyseal plate size  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
increased startle reflex  (IEA)
increased susceptibility to xenobiotic induced morbidity/mortality  (IAGP)
increased thyroid-stimulating hormone level  (IAGP)
increased total body fat amount  (IAGP)
increased trabecular bone thickness  (IAGP)
increased trabecular bone volume  (IAGP)
increased triiodothyronine level  (IAGP)
increased vertical activity  (IEA)
insulin resistance  (IAGP)
irregular heartbeat  (IAGP)
large fontanelles  (IAGP)
limb grasping  (IEA)
obese  (IAGP)
oliguria  (IAGP)
osteosclerosis  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IEA)
prolonged estrous cycle  (IAGP)
prolonged QRS complex duration  (IAGP)
prolonged QT interval  (IAGP)
reduced female fertility  (IAGP)
reduced fertility  (IAGP)
reduced male fertility  (IAGP)
short femur  (IAGP)
short limbs  (IAGP)
short tail  (IAGP)
short tibia  (IAGP)
short ulna  (IAGP)
small heart  (IAGP)
small pancreatic islets  (IAGP)
small pituitary gland  (IAGP)
thyroid gland hyperplasia  (IAGP)
thyroid gland hypoplasia  (IAGP)
wide cranial sutures  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. A human c-erbA oncogene homologue is closely proximal to the chromosome 17 breakpoint in acute promyelocytic leukemia. Dayton AI, etal., Proc Natl Acad Sci U S A. 1984 Jul;81(14):4495-9.
2. Expression of mutant thyroid hormone nuclear receptors is associated with human renal clear cell carcinoma. Kamiya Y, etal., Carcinogenesis. 2002 Jan;23(1):25-33.
3. Thyroid receptor alpha1 and alpha2 mutations in nonfunctioning pituitary tumors. McCabe CJ, etal., J Clin Endocrinol Metab. 1999 Feb;84(2):649-53.
4. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Time-dependent changes in the expression of thyroid hormone receptor alpha 1 in the myocardium after acute myocardial infarction: possible implications in cardiac remodelling. Pantos C, etal., Eur J Endocrinol. 2007 Apr;156(4):415-24.
9. Functionally impaired TR mutants are present in thyroid papillary cancer. Puzianowska-Kuznicka M, etal., J Clin Endocrinol Metab. 2002 Mar;87(3):1120-8.
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Expression of thyroid hormone receptor/erbA genes is altered in human breast cancer. Silva JM, etal., Oncogene. 2002 Jun 20;21(27):4307-16.
Additional References at PubMed
PMID:1225760   PMID:1302014   PMID:1352161   PMID:1427919   PMID:1676978   PMID:1679528   PMID:1794055   PMID:1850510   PMID:1889803   PMID:1889815   PMID:1944303   PMID:2162045  
PMID:2286379   PMID:2349106   PMID:2539258   PMID:2567264   PMID:2851124   PMID:2879243   PMID:3116273   PMID:3399404   PMID:3416641   PMID:3629259   PMID:5309548   PMID:6087351  
PMID:6328658   PMID:6594688   PMID:6690234   PMID:7507509   PMID:7557995   PMID:7566114   PMID:7613042   PMID:7613043   PMID:7760812   PMID:7769664   PMID:7838156   PMID:7838158  
PMID:7935490   PMID:7956352   PMID:8103600   PMID:8251184   PMID:8389625   PMID:8439732   PMID:8449498   PMID:8507984   PMID:8559662   PMID:8595891   PMID:8889548   PMID:8910392  
PMID:8910441   PMID:9177778   PMID:9250685   PMID:9259319   PMID:9337410   PMID:9372952   PMID:9430637   PMID:9620453   PMID:9859898   PMID:9861043   PMID:9927422   PMID:10337632  
PMID:10346821   PMID:10348820   PMID:10349636   PMID:10362681   PMID:10430610   PMID:10605006   PMID:10681503   PMID:10691312   PMID:10712278   PMID:10769387   PMID:10848522   PMID:10922068  
PMID:11042159   PMID:11075809   PMID:11076861   PMID:11113349   PMID:11120878   PMID:11138006   PMID:11159823   PMID:11180952   PMID:11217851   PMID:11222741   PMID:11222747   PMID:11259580  
PMID:11416150   PMID:11416151   PMID:11481455   PMID:11496110   PMID:11572786   PMID:11641275   PMID:11725045   PMID:11726557   PMID:11731612   PMID:11731613   PMID:11734632   PMID:11739587  
PMID:11773436   PMID:11786385   PMID:11843482   PMID:11867729   PMID:11891331   PMID:11940593   PMID:12039959   PMID:12054736   PMID:12072400   PMID:12127686   PMID:12145333   PMID:12150932  
PMID:12169435   PMID:12198244   PMID:12356724   PMID:12388168   PMID:12438746   PMID:12456652   PMID:12466851   PMID:12477932   PMID:12556906   PMID:12562961   PMID:12576486   PMID:12581880  
PMID:12591179   PMID:12591240   PMID:12677005   PMID:12750454   PMID:12776178   PMID:12782404   PMID:12845557   PMID:12869545   PMID:12888625   PMID:12933686   PMID:14610273   PMID:14627645  
PMID:14630717   PMID:14630998   PMID:14681479   PMID:14726446   PMID:14729678   PMID:15062575   PMID:15180993   PMID:15240882   PMID:15304375   PMID:15322135   PMID:15340084   PMID:15374821  
PMID:15601836   PMID:15618518   PMID:15673575   PMID:15713690   PMID:15780976   PMID:15782199   PMID:15802493   PMID:15808842   PMID:15845618   PMID:15858214   PMID:16051666   PMID:16131613  
PMID:16141072   PMID:16141073   PMID:16150908   PMID:16322094   PMID:16571082   PMID:16579977   PMID:16581794   PMID:16602821   PMID:16648291   PMID:16803873   PMID:16902998   PMID:16919471  
PMID:17065405   PMID:17122078   PMID:17129617   PMID:17210747   PMID:17220280   PMID:17317766   PMID:17327419   PMID:17488972   PMID:17520268   PMID:17601882   PMID:17622582   PMID:17872380  
PMID:17932484   PMID:17952069   PMID:18203951   PMID:18287507   PMID:18287559   PMID:18575627   PMID:18641393   PMID:18795907   PMID:18799693   PMID:19001373   PMID:19074585   PMID:19094093  
PMID:19114539   PMID:19131509   PMID:19210427   PMID:19244534   PMID:19282388   PMID:19462004   PMID:19477936   PMID:19549593   PMID:19782026   PMID:20059953   PMID:20062085   PMID:20080985  
PMID:20090848   PMID:20114049   PMID:20153760   PMID:20159955   PMID:20160073   PMID:20194731   PMID:20228172   PMID:20412781   PMID:20529852   PMID:20566868   PMID:20580649   PMID:20709911  
PMID:20726222   PMID:20739404   PMID:20932939   PMID:21292823   PMID:21344381   PMID:21389087   PMID:21566120   PMID:21621530   PMID:21652727   PMID:21677750   PMID:21858227   PMID:21873635  
PMID:21914860   PMID:22001906   PMID:22109994   PMID:22147010   PMID:22253431   PMID:22322976   PMID:22361821   PMID:22392896   PMID:22468949   PMID:22539677   PMID:22570333   PMID:22586439  
PMID:22891348   PMID:22892567   PMID:22930759   PMID:22988430   PMID:23161871   PMID:23257356   PMID:23341629   PMID:23398480   PMID:23493375   PMID:23567476   PMID:23595988   PMID:23610395  
PMID:24012852   PMID:24040148   PMID:24098680   PMID:24194600   PMID:24265449   PMID:24346699   PMID:24381310   PMID:24395638   PMID:24644288   PMID:24725081   PMID:24731098   PMID:24792211  
PMID:24797634   PMID:24847117   PMID:24848360   PMID:24914936   PMID:24914940   PMID:24952961   PMID:25254665   PMID:25263706   PMID:25479311   PMID:25487743   PMID:25500991   PMID:25657324  
PMID:25774556   PMID:25793522   PMID:25866873   PMID:25867707   PMID:26286942   PMID:26319697   PMID:26451739   PMID:26453307   PMID:26672044   PMID:26727108   PMID:26743578   PMID:26970082  
PMID:27135601   PMID:27247403   PMID:27519547   PMID:27626380   PMID:27967605   PMID:28011173   PMID:28875931   PMID:28910278   PMID:28911178   PMID:29205102   PMID:29229863   PMID:29273766  
PMID:29377458   PMID:29648626   PMID:29688375   PMID:29753845   PMID:30092589   PMID:30292450   PMID:30595106   PMID:30846611   PMID:31439911   PMID:31789450   PMID:32122258   PMID:32289320  
PMID:32325033   PMID:32453730   PMID:32776612   PMID:32924834   PMID:33003470   PMID:33267733   PMID:33526032   PMID:33633251   PMID:33757992   PMID:34086893   PMID:34248495   PMID:34321999  
PMID:34474245   PMID:34916557   PMID:35196498   PMID:35697700   PMID:35700264   PMID:35753757   PMID:36103385   PMID:36217307   PMID:36288084   PMID:36374165   PMID:36753417   PMID:37992217  
PMID:38149585   PMID:38183987   PMID:38355793   PMID:38643465   PMID:38757582   PMID:38889231   PMID:39175769  


Genomics

Comparative Map Data
Thra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,631,539 - 98,659,832 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,631,464 - 98,659,832 (+)EnsemblGRCm39 Ensembl
GRCm381198,740,776 - 98,769,006 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,740,638 - 98,769,006 (+)EnsemblGRCm38mm10GRCm38
MGSCv371198,603,187 - 98,626,425 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361198,557,963 - 98,581,201 (+)NCBIMGSCv36mm8
Celera11108,407,991 - 108,419,811 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1162.58NCBI
THRA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381740,062,193 - 40,093,867 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1740,058,290 - 40,093,867 (+)EnsemblGRCh38hg38GRCh38
GRCh371738,218,446 - 38,250,120 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,472,589 - 35,503,646 (+)NCBINCBI36Build 36hg18NCBI36
Build 341735,472,588 - 35,499,815NCBI
Celera1734,878,512 - 34,910,230 (+)NCBICelera
Cytogenetic Map17q21.1NCBI
HuRef1734,012,227 - 34,043,856 (+)NCBIHuRef
CHM1_11738,454,163 - 38,485,823 (+)NCBICHM1_1
T2T-CHM13v2.01740,926,078 - 40,957,752 (+)NCBIT2T-CHM13v2.0
Thra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81084,198,141 - 84,225,659 (+)NCBIGRCr8
mRatBN7.21083,701,885 - 83,729,408 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,700,755 - 83,729,936 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1088,645,759 - 88,673,285 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01088,143,834 - 88,171,360 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01083,536,535 - 83,564,061 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01086,657,285 - 86,684,935 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,657,285 - 86,684,933 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,453,436 - 86,480,928 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,514,443 - 87,542,306 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11087,540,629 - 87,556,674 (+)NCBI
Celera1082,449,971 - 82,477,615 (+)NCBICelera
RH 3.4 Map10839.79RGD
Cytogenetic Map10q31NCBI
Thra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,731,746 - 14,744,367 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,731,746 - 14,743,545 (+)NCBIChiLan1.0ChiLan1.0
THRA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21924,861,063 - 24,892,111 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11726,755,863 - 26,786,898 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01717,196,459 - 17,226,263 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11717,420,186 - 17,448,502 (-)NCBIpanpan1.1PanPan1.1panPan2
THRA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,469,466 - 22,493,445 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,468,594 - 22,493,445 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha921,941,798 - 21,965,472 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0923,262,655 - 23,286,090 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,261,287 - 23,285,973 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1922,036,085 - 22,059,532 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,295,080 - 22,318,722 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,419,817 - 22,443,287 (-)NCBIUU_Cfam_GSD_1.0
Thra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560221,869,085 - 21,886,778 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649015,193,150 - 15,206,784 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649015,188,341 - 15,206,032 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THRA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,270,062 - 22,296,618 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,270,506 - 22,296,684 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21222,488,984 - 22,497,735 (+)NCBISscrofa10.2Sscrofa10.2susScr3
THRA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11666,087,071 - 66,118,137 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607736,990,432 - 37,021,543 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Thra
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247953,108,854 - 3,132,464 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247953,109,663 - 3,132,494 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Thra
1335 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1860
Count of miRNA genes:672
Interacting mature miRNAs:883
Transcripts:ENSMUST00000064187, ENSMUST00000103139, ENSMUST00000124072, ENSMUST00000124130, ENSMUST00000142944, ENSMUST00000150693, ENSMUST00000152195, ENSMUST00000153043, ENSMUST00000153468
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196176465108806384Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1196897693110603991Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187691198103274115Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
1301153Estq3_mestradiol regulated response QTL 3 (mouse)Not determined119689769399327028Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1301491Abbp4_mA/J and C57BL/6 blood pressure 4 (mouse)Not determined118869958899081597Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117757387399377820Mouse

Markers in Region
Thra  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381198,764,489 - 98,765,090UniSTSGRCm38
MGSCv371198,625,803 - 98,626,404UniSTSGRCm37
Celera11108,419,189 - 108,419,790UniSTS
Cytogenetic Map11D-EUniSTS
cM Map1157.0UniSTS
PMC64989P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381198,764,238 - 98,764,546UniSTSGRCm38
MGSCv371198,625,552 - 98,625,860UniSTSGRCm37
Celera11108,418,938 - 108,419,246UniSTS
Cytogenetic Map11D-EUniSTS
PMC87157P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381198,763,505 - 98,764,466UniSTSGRCm38
MGSCv371198,624,819 - 98,625,780UniSTSGRCm37
Celera11108,418,205 - 108,419,166UniSTS
Cytogenetic Map11D-EUniSTS
PMC87157P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381198,763,529 - 98,764,363UniSTSGRCm38
MGSCv371198,624,843 - 98,625,677UniSTSGRCm37
Celera11108,418,229 - 108,419,063UniSTS
Cytogenetic Map11D-EUniSTS
AW259572  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381198,768,711 - 98,768,803UniSTSGRCm38
MGSCv371198,630,025 - 98,630,117UniSTSGRCm37
Celera11108,423,377 - 108,423,469UniSTS
Cytogenetic Map11D-EUniSTS
Cytogenetic Map11DUniSTS
Whitehead/MRC_RH111306.72UniSTS
D17S2189  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381198,766,296 - 98,766,508UniSTSGRCm38
MGSCv371198,627,610 - 98,627,822UniSTSGRCm37
Celera11108,420,996 - 108,421,164UniSTS
Cytogenetic Map11D-EUniSTS
MARC_26124-26125:1030369359:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381198,763,739 - 98,764,327UniSTSGRCm38
MGSCv371198,625,053 - 98,625,641UniSTSGRCm37
Celera11108,418,439 - 108,419,027UniSTS
Cytogenetic Map11D-EUniSTS
THRA_2263  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381198,768,172 - 98,768,937UniSTSGRCm38
MGSCv371198,629,486 - 98,630,251UniSTSGRCm37
Celera11108,422,828 - 108,423,603UniSTS
Cytogenetic Map11DUniSTS
Cytogenetic Map11D-EUniSTS
PMC64989P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381198,764,292 - 98,764,546UniSTSGRCm38
MGSCv371198,625,606 - 98,625,860UniSTSGRCm37
Celera11108,418,992 - 108,419,246UniSTS
Cytogenetic Map11D-EUniSTS
Thra  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381198,764,620 - 98,764,699UniSTSGRCm38
MGSCv371198,625,934 - 98,626,013UniSTSGRCm37
Celera11108,419,320 - 108,419,399UniSTS
Cytogenetic Map11D-EUniSTS
cM Map1157.0UniSTS
THRA  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381198,760,977 - 98,761,916UniSTSGRCm38
MGSCv371198,622,291 - 98,623,230UniSTSGRCm37
Celera11108,415,676 - 108,416,616UniSTS
Cytogenetic Map11D-EUniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001313983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_178060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK078233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK082121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL590963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY965038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB357897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC046795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ117879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X07750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X07751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X07752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X51983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000064187   ⟹   ENSMUSP00000068281
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,632,637 - 98,659,832 (+)Ensembl
GRCm38.p6 Ensembl1198,741,811 - 98,769,006 (+)Ensembl
Ensembl Acc Id: ENSMUST00000103139   ⟹   ENSMUSP00000099428
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,632,699 - 98,655,937 (+)Ensembl
GRCm38.p6 Ensembl1198,741,873 - 98,765,111 (+)Ensembl
Ensembl Acc Id: ENSMUST00000124072   ⟹   ENSMUSP00000115323
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,644,412 - 98,659,229 (+)Ensembl
GRCm38.p6 Ensembl1198,753,586 - 98,768,403 (+)Ensembl
Ensembl Acc Id: ENSMUST00000124130
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,631,730 - 98,644,268 (+)Ensembl
GRCm38.p6 Ensembl1198,740,904 - 98,753,442 (+)Ensembl
Ensembl Acc Id: ENSMUST00000142944
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,631,464 - 98,644,205 (+)Ensembl
GRCm38.p6 Ensembl1198,740,638 - 98,753,379 (+)Ensembl
Ensembl Acc Id: ENSMUST00000150693
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,635,059 - 98,644,603 (+)Ensembl
GRCm38.p6 Ensembl1198,744,233 - 98,753,777 (+)Ensembl
Ensembl Acc Id: ENSMUST00000152195
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,632,637 - 98,648,521 (+)Ensembl
GRCm38.p6 Ensembl1198,741,811 - 98,757,695 (+)Ensembl
Ensembl Acc Id: ENSMUST00000153043   ⟹   ENSMUSP00000123056
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,632,984 - 98,647,821 (+)Ensembl
GRCm38.p6 Ensembl1198,742,158 - 98,756,995 (+)Ensembl
Ensembl Acc Id: ENSMUST00000153468
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,631,627 - 98,644,464 (+)Ensembl
GRCm38.p6 Ensembl1198,740,801 - 98,753,638 (+)Ensembl
RefSeq Acc Id: NM_001313983   ⟹   NP_001300912
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391198,632,611 - 98,659,832 (+)NCBI
GRCm381198,741,785 - 98,769,006 (+)NCBI
Sequence:
RefSeq Acc Id: NM_178060   ⟹   NP_835161
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391198,632,611 - 98,655,939 (+)NCBI
GRCm381198,741,785 - 98,765,113 (+)NCBI
MGSCv371198,603,187 - 98,626,425 (+)RGD
Celera11108,407,991 - 108,419,811 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030245916   ⟹   XP_030101776
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391198,631,539 - 98,658,572 (+)NCBI
GRCm381198,740,776 - 98,768,139 (+)NCBI
Sequence:
RefSeq Acc Id: NP_835161   ⟸   NM_178060
- Peptide Label: isoform 2
- UniProtKB: A0A0R4J1R8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001300912   ⟸   NM_001313983
- Peptide Label: isoform 1
- UniProtKB: P63058 (UniProtKB/Swiss-Prot),   Q80Y90 (UniProtKB/Swiss-Prot),   Q542U8 (UniProtKB/Swiss-Prot),   A3KFN4 (UniProtKB/Swiss-Prot),   A0A0R4J1R8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030101776   ⟸   XM_030245916
- Peptide Label: isoform X1
- UniProtKB: A0A0R4J1R8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000115323   ⟸   ENSMUST00000124072
Ensembl Acc Id: ENSMUSP00000123056   ⟸   ENSMUST00000153043
Ensembl Acc Id: ENSMUSP00000068281   ⟸   ENSMUST00000064187
Ensembl Acc Id: ENSMUSP00000099428   ⟸   ENSMUST00000103139
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63058-F1-model_v2 AlphaFold P63058 1-492 view protein structure

Promoters
RGD ID:6822309
Promoter ID:MM_KWN:9604
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   Brain,   MEF_B6
Transcripts:OTTMUST00000014601,   OTTMUST00000014604,   OTTMUST00000014605
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361198,601,629 - 98,602,129 (+)MPROMDB
RGD ID:6822308
Promoter ID:MM_KWN:9605
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:NM_178060,   OTTMUST00000014597,   OTTMUST00000014598,   OTTMUST00000014603
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361198,603,096 - 98,603,596 (+)MPROMDB
RGD ID:6822311
Promoter ID:MM_KWN:9606
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung
Transcripts:OTTMUST00000014602
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361198,605,261 - 98,605,761 (+)MPROMDB
RGD ID:6822310
Promoter ID:MM_KWN:9607
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:UC007LHG.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361198,614,176 - 98,614,676 (+)MPROMDB
RGD ID:8676516
Promoter ID:EPDNEW_M16288
Type:initiation region
Name:Thra_1
Description:Mus musculus thyroid hormone receptor alpha , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381198,741,879 - 98,741,939EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98742 AgrOrtholog
Ensembl Genes ENSMUSG00000058756 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000064187 ENTREZGENE
  ENSMUST00000064187.12 UniProtKB/Swiss-Prot
  ENSMUST00000103139 ENTREZGENE
  ENSMUST00000103139.11 UniProtKB/Swiss-Prot
  ENSMUST00000124072.2 UniProtKB/TrEMBL
  ENSMUST00000153043.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_hormone_rcpt_NR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ThyrH_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21833 UniProtKB/Swiss-Prot
MGD MGI:98742 ENTREZGENE
NCBI Gene 21833 ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THYROID HORMONE RECEPTOR ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Thra PhenoGen
PRINTS STRDHORMONER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THYROIDHORMR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOLI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48508 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4J1R8 ENTREZGENE, UniProtKB/TrEMBL
  A3KFN4 ENTREZGENE
  A3KFN7_MOUSE UniProtKB/TrEMBL
  P63058 ENTREZGENE
  Q542U8 ENTREZGENE
  Q80Y90 ENTREZGENE
  THA_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary A3KFN4 UniProtKB/Swiss-Prot
  P10685 UniProtKB/Swiss-Prot
  P15827 UniProtKB/Swiss-Prot
  P16416 UniProtKB/Swiss-Prot
  P37241 UniProtKB/Swiss-Prot
  Q542U8 UniProtKB/Swiss-Prot
  Q63107 UniProtKB/Swiss-Prot
  Q63195 UniProtKB/Swiss-Prot
  Q63196 UniProtKB/Swiss-Prot
  Q80Y90 UniProtKB/Swiss-Prot
  Q99146 UniProtKB/Swiss-Prot