Th (tyrosine hydroxylase) - Rat Genome Database

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Pathways
Gene: Th (tyrosine hydroxylase) Mus musculus
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Symbol: Th
Name: tyrosine hydroxylase
RGD ID: 11414
MGI Page MGI
Description: Predicted to enable several functions, including cation binding activity; oxygen binding activity; and tyrosine 3-monooxygenase activity. Involved in eye development and visual perception. Acts upstream of or within several processes, including dopamine biosynthetic process from tyrosine; dopaminergic synaptic transmission; and learning or memory. Located in several cellular components, including axon; perikaryon; and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; eye; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinsonism; heroin dependence; hypertension; and obesity. Orthologous to human TH (tyrosine hydroxylase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: tyrosine 3-hydroxylase; tyrosine 3-monooxygenase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397142,446,516 - 142,453,732 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7142,446,489 - 142,484,865 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm387142,892,779 - 142,899,995 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7142,892,752 - 142,931,128 (-)Ensemblmm10GRCm38
MGSCv377150,078,681 - 150,085,871 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367142,702,166 - 142,709,356 (-)NCBIMGSCv36mm8
Celera7142,648,392 - 142,655,582 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.06NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Beckwith-Wiedemann syndrome  (ISO)
brain disease  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Catalepsy  (ISO)
congestive heart failure  (IMP,ISO)
Contusions  (ISO)
delta beta-thalassemia  (ISO)
depressive disorder  (ISO)
developmental and epileptic encephalopathy  (ISO)
DOPA-responsive dystonia  (ISO)
Drug-Induced Dyskinesia  (ISO)
dystonia  (ISO)
epilepsy  (ISO)
essential hypertension  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
generalized dystonia  (ISO)
genetic disease  (ISO)
heart disease  (ISO)
hepatocellular carcinoma  (ISO)
heroin dependence  (ISO)
Hyperkinesis  (ISO)
Hyperproinsulinemia  (ISO)
hyperprolactinemia  (ISO)
hypertension  (ISO)
hypoglycemia  (ISO)
Hypoinsulinemia  (ISO)
immunodeficiency 39  (ISO)
intellectual disability  (IEP,ISO)
learning disability  (ISO)
Lewy body dementia  (ISO)
Machado-Joseph disease  (ISO)
maturity-onset diabetes of the young  (ISO)
maturity-onset diabetes of the young type 1  (ISO)
maturity-onset diabetes of the young type 10  (ISO)
middle cerebral artery infarction  (ISO)
myocardial infarction  (ISO)
neonatal diabetes mellitus  (ISO)
Nerve Degeneration  (ISO)
neuroblastoma  (ISO)
neuronal ceroid lipofuscinosis  (ISO)
obesity  (ISO)
Parkinson's disease  (IEP,ISO)
Parkinsonism  (ISO)
Permanent Neonatal Diabetes Mellitus 4  (ISO)
pheochromocytoma  (ISO)
polycystic ovary syndrome  (ISO)
portal hypertension  (ISO)
Reperfusion Injury  (ISO)
schizophrenia  (ISO)
Segawa Syndrome, Autosomal Recessive  (ISO)
transient neonatal diabetes mellitus  (ISO)
traumatic brain injury  (ISO)
type 1 diabetes mellitus  (ISO)
type 1 diabetes mellitus 2  (ISO)
type 2 diabetes mellitus  (ISO)
Type 2 Diabetes Mellitus 1  (ISO)
uremia  (ISO)
withdrawal disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-sesamin  (ISO)
(+)-taxifolin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-selegiline  (ISO)
(R)-adrenaline  (EXP,ISO)
(R)-noradrenaline  (EXP,ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-AMPA  (ISO)
(S)-amphetamine  (EXP)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP,ISO)
1-Naphthylacetylspermine  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (EXP,ISO)
2',5'-Dideoxyadenosine  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
3,4-dihydroxyphenylacetaldehyde  (ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (EXP)
3,7-dihydropurine-6-thione  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-Amino-1-methyl-5H-pyrido[4,3-b]indole  (ISO)
3-hydroxybutyric acid  (EXP)
3-methyladenine  (ISO)
3-phenylprop-2-enal  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-phenylbutyric acid  (EXP)
5-(2-chloroethyl)-4-methylthiazole  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
7-nitroindazole  (EXP)
8-bromo-3',5'-cyclic GMP  (ISO)
9-cis-retinoic acid  (ISO)
acetic acid  (EXP)
acetylcholine  (ISO)
acrylamide  (ISO)
acrylonitrile  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
agmatine  (ISO)
albiflorin  (ISO)
all-trans-retinoic acid  (EXP,ISO)
AM-251  (ISO)
amentoflavone  (EXP)
aminoguanidine  (EXP)
amitraz  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amphetamine  (EXP,ISO)
apigenin  (ISO)
apocynin  (ISO)
aprepitant  (ISO)
Aroclor 1254  (EXP,ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
asiaticoside  (ISO)
atrazine  (ISO)
baicalein  (EXP)
baicalin  (EXP)
Bardoxolone methyl  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-lapachone  (ISO)
bicuculline  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
BQ 123  (ISO)
bromochloroacetic acid  (EXP)
bucladesine  (ISO)
butanal  (ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
calcitriol  (ISO)
cannabidiol  (EXP)
carmustine  (ISO)
carnosic acid  (ISO)
Carnosol  (EXP)
carvedilol  (ISO)
chelerythrine  (ISO)
chitosan  (ISO)
Chloralose  (ISO)
chlorisondamine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clozapine  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP,ISO)
corticosterone  (EXP)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cyanazine  (ISO)
cyanocob(III)alamin  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
cytarabine  (ISO)
dabigatran  (ISO)
DDE  (ISO)
desferrioxamine B  (ISO)
desipramine  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dichlorvos  (ISO)
dieldrin  (ISO)
diethyldithiocarbamic acid  (ISO)
dioxygen  (ISO)
dipyridamole  (ISO)
dopamine  (EXP,ISO)
dopaminechrome (enol form)  (ISO)
edaravone  (ISO)
elemental selenium  (ISO)
enzacamene  (ISO)
epibatidine  (ISO)
ethanol  (EXP,ISO)
fasudil  (ISO)
fenvalerate  (ISO)
ferrostatin-1  (EXP)
fipronil  (ISO)
flavonoids  (ISO)
fluoxetine  (EXP,ISO)
formaldehyde  (EXP)
fructose  (EXP)
ganglioside GM1  (ISO)
genistein  (EXP,ISO)
geraniol  (EXP)
ginkgetin  (EXP)
ginsenoside Re  (EXP,ISO)
glyburide  (EXP)
glycidol  (ISO)
guanethidine  (ISO)
GW 1929  (ISO)
haloperidol  (ISO)
heptachlor  (EXP)
herbicide  (ISO)
hydrogen peroxide  (ISO)
icariin  (ISO)
idazoxan  (ISO)
imidacloprid  (ISO)
juglone  (EXP)
ketoconazole  (EXP)
KT 5720  (ISO)
L-ascorbic acid  (EXP,ISO)
lead(0)  (EXP)
linalool  (ISO)
linuron  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lovastatin  (EXP,ISO)
LY294002  (EXP)
malathion  (EXP)
maneb  (EXP,ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
manganese(II) sulfate  (ISO)
melatonin  (EXP,ISO)
mephedrone  (EXP,ISO)
mercaptopurine  (ISO)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methoxychlor  (ISO)
methyllycaconitine  (ISO)
methylmercury chloride  (EXP)
methylphenidate  (EXP)
mevalonic acid  (EXP,ISO)
mifepristone  (ISO)
minocycline  (EXP)
misonidazole  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monocrotophos  (ISO)
monosodium L-glutamate  (ISO)
montelukast  (ISO)
morphine  (EXP,ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-ethylmaleimide  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
naloxone  (EXP,ISO)
naltrexone  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (EXP,ISO)
nimodipine  (ISO)
nitroprusside  (ISO)
Nookatone  (ISO)
Norbinaltorphimine  (EXP)
olanzapine  (ISO)
oleuropein  (EXP)
oridonin  (ISO)
Ortho-topolin riboside  (ISO)
oxidopamine  (EXP,ISO)
P(1),P(4)-bis(5'-adenosyl) tetraphosphate  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
pentanal  (ISO)
perfluorodecanoic acid  (EXP)
perfluorododecanoic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
perfluoroundecanoic acid  (EXP)
permethrin  (ISO)
phencyclidine  (EXP)
Phenelzine  (ISO)
phenethyl caffeate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
piperazine  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
pregabalin  (EXP)
probenecid  (EXP)
progesterone  (ISO)
propanal  (ISO)
propionic acid  (ISO)
propofol  (EXP)
prothioconazole  (ISO)
purine-6-thiol  (ISO)
pyrrolidine dithiocarbamate  (EXP)
pyrroloquinoline quinone  (EXP,ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
reserpine  (EXP,ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
risperidone  (ISO)
rotenone  (EXP,ISO)
rottlerin  (EXP,ISO)
rutin  (ISO)
salubrinal  (ISO)
saxagliptin  (ISO)
SB 203580  (ISO)
SCH 23390  (EXP)
selenium atom  (ISO)
simazine  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium benzoate  (EXP)
sodium chloride  (ISO)
Sophoricoside  (EXP)
spiperone  (ISO)
streptozocin  (ISO)
sulforaphane  (EXP)
sulpiride  (EXP,ISO)
Talipexole dihydrochloride  (EXP)
tamoxifen  (EXP,ISO)
taurine  (EXP)
telmisartan  (EXP)
testosterone  (ISO)
topiramate  (EXP)
trichloroethene  (ISO)
triprolidine  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vitamin D  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
WIN 55212-2  (EXP,ISO)
wortmannin  (EXP,ISO)
Y-27632  (EXP)
zearalenone  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)
zonisamide  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aminergic neurotransmitter loading into synaptic vesicle  (ISO)
animal organ morphogenesis  (IMP)
aromatic amino acid metabolic process  (IEA)
catecholamine biosynthetic process  (IEA,ISO)
cellular response to alkaloid  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to manganese ion  (ISO)
cellular response to nicotine  (ISO)
cellular response to xenobiotic stimulus  (ISO)
cerebral cortex development  (ISO)
circadian sleep/wake cycle  (ISO)
cognition  (IBA,ISO)
dopamine biosynthetic process  (IEA,ISO)
dopamine biosynthetic process from tyrosine  (IBA,IDA,IEA,IMP,ISO,TAS)
eating behavior  (IGI,IMP)
embryonic camera-type eye morphogenesis  (IMP)
epinephrine biosynthetic process  (IBA,IEA,ISO)
eye photoreceptor cell development  (IMP)
fatty acid metabolic process  (ISO)
glycoside metabolic process  (ISO)
heart development  (IEA,IMP,ISO)
hyaloid vascular plexus regression  (IMP)
isoquinoline alkaloid metabolic process  (ISO)
learning  (IMP)
locomotory behavior  (IGI,IMP)
mating behavior  (IBA,IMP)
memory  (IMP)
norepinephrine biosynthetic process  (IBA,IEA,ISO)
phthalate metabolic process  (ISO)
phytoalexin metabolic process  (ISO)
regulation of heart contraction  (IMP)
response to activity  (ISO)
response to amphetamine  (ISO)
response to corticosterone  (ISO)
response to curcumin  (ISO)
response to electrical stimulus  (ISO)
response to estradiol  (ISO)
response to ethanol  (IEA,ISO)
response to ether  (ISO)
response to growth factor  (ISO)
response to herbicide  (ISO)
response to hypoxia  (IEA,ISO)
response to immobilization stress  (ISO)
response to insecticide  (ISO)
response to isolation stress  (ISO)
response to light stimulus  (ISO)
response to lipopolysaccharide  (ISO)
response to metal ion  (ISO)
response to nicotine  (ISO)
response to nutrient levels  (ISO)
response to peptide hormone  (ISO)
response to pyrethroid  (ISO)
response to salt stress  (ISO)
response to steroid hormone  (ISO)
response to xenobiotic stimulus  (ISO)
response to zinc ion  (ISO)
serotonin biosynthetic process  (IBA)
social behavior  (ISO)
sphingolipid metabolic process  (ISO)
synaptic transmission, dopaminergic  (IBA,IMP)
terpene metabolic process  (ISO)
visual perception  (IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal active avoidance behavior  (IAGP)
abnormal adrenal chromaffin cell morphology  (IAGP)
abnormal adrenaline level  (IAGP)
abnormal associative learning  (IAGP)
abnormal avoidance learning behavior  (IAGP)
abnormal conditioned taste aversion behavior  (IAGP)
abnormal cued conditioning behavior  (IAGP)
abnormal dopaminergic neuron morphology  (IAGP)
abnormal eating behavior  (IAGP)
abnormal eye electrophysiology  (IAGP)
abnormal eye physiology  (IAGP)
abnormal gait  (IAGP)
abnormal heart atrium morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal learning/memory/conditioning  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal motor coordination/balance  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal noradrenaline level  (IAGP)
abnormal pain threshold  (IAGP)
abnormal physiological response to hypoxia  (IAGP)
abnormal postnatal growth  (IAGP)
abnormal ST segment  (IAGP)
abnormal type I cell of carotid body physiology  (IAGP)
abnormal vision  (IAGP)
adipsia  (IAGP)
adrenal gland hyperplasia  (IAGP)
akinesia  (IAGP)
alpha-synuclein inclusion body  (IAGP)
anoxia  (IAGP)
aphagia  (IAGP)
atelectasis  (IAGP)
blood vessel congestion  (IAGP)
bradykinesia  (IAGP)
catalepsy  (IAGP)
decreased birth body size  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased brain size  (IAGP)
decreased chemically-elicited antinociception  (IAGP)
decreased compensatory feeding amount  (IAGP)
decreased dopamine level  (IAGP)
decreased food intake  (IAGP)
decreased heart rate  (IAGP)
decreased locomotor activity  (IAGP)
decreased neuron number  (IAGP)
decreased noradrenaline level  (IAGP)
decreased stereotypic behavior  (IAGP)
dilated heart atrium  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
excessive scratching  (IAGP)
fetal cardiomyocyte disarray  (IAGP)
fetal cardiomyocyte vacuoles  (IAGP)
gliosis  (IAGP)
heart vascular congestion  (IAGP)
hunched posture  (IAGP)
hyperactivity  (IAGP)
hyporesponsive to tactile stimuli  (IAGP)
impaired behavioral response to addictive substance  (IAGP)
impaired coordination  (IAGP)
increased food intake  (IAGP)
increased metastatic potential  (IAGP)
increased neuroblastoma incidence  (IAGP)
increased pruritus  (IAGP)
increased serotonin level  (IAGP)
increased stereotypic behavior  (IAGP)
increased thermal nociceptive threshold  (IAGP)
increased thigmotaxis  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
liver vascular congestion  (IAGP)
loss of dopaminergic neurons  (IAGP)
mixed cellular infiltration to dermis  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neuron degeneration  (IAGP)
no abnormal phenotype detected  (IAGP)
oxidative stress  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
poor grooming  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
respiratory failure  (IAGP)
skin lesions  (IAGP)
thick epidermis  (IAGP)
ventricular hypoplasia  (IAGP)
visceral vascular congestion  (IAGP)
weakness  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. The activity of some neurotransmitter-synthetizing enzymes in experimental cobalt epilepsy. Altamura AC, etal., Neurosci Lett. 1978 Jan;7(1):83-7.
2. Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease. Alves S, etal., Hum Mol Genet. 2008 Jul 15;17(14):2071-83. Epub 2008 Apr 1.
3. Nicotine dependence in a prospective population-based study of adolescents: the protective role of a functional tyrosine hydroxylase polymorphism. Anney RJ, etal., Pharmacogenetics. 2004 Feb;14(2):73-81.
4. A human tyrosine hydroxylase isoform associated with progressive supranuclear palsy shows altered enzymatic activity. Bodeau-Pean S, etal., J Biol Chem. 1999 Feb 5;274(6):3469-75.
5. Selective losses of brainstem catecholamine neurons after hypoxia-ischemia in the immature rat pup. Buller KM, etal., Pediatr Res. 2008 Apr;63(4):364-9.
6. Activation of Different Neuronal Phenotypes in the Rat Brain Induced by Liver Ischemia-Reperfusion Injury: Dual Fos/Neuropeptide Immunohistochemistry. Bundzikova J, etal., Cell Mol Neurobiol. 2010 Nov 9.
7. Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease. Cederfjäll E, etal., Sci Rep. 2013;3:2157. doi: 10.1038/srep02157.
8. Down-regulation of genes related to the adrenergic system may contribute to splanchnic vasodilation in rat portal hypertension. Coll M, etal., J Hepatol. 2008 Jul;49(1):43-51. Epub 2008 Apr 18.
9. Atrophy of mesenteric sympathetic innervation may contribute to splanchnic vasodilation in rat portal hypertension. Coll M, etal., Liver Int. 2010 Apr;30(4):593-602. Epub 2009 Nov 30.
10. Tyrosine hydroxylase Val-81-Met polymorphism associated with early-onset alcoholism. Dahmen N, etal., Psychiatr Genet. 2005 Mar;15(1):13-6.
11. Measurement of intrinsic rate constants in the tyrosine hydroxylase reaction. Eser BE and Fitzpatrick PF, Biochemistry. 2010 Jan 26;49(3):645-52.
12. Behavioral recovery in 6-hydroxydopamine-lesioned rats by cotransduction of striatum with tyrosine hydroxylase and aromatic L-amino acid decarboxylase genes using two separate adeno-associated virus vectors. Fan DS, etal., Hum Gene Ther. 1998 Nov 20;9(17):2527-35.
13. Symptom-relieving and neuroprotective effects of the phytocannabinoid D(9) -THCV in animal models of Parkinson's disease. Garcia C, etal., Br J Pharmacol. 2011 Feb 16. doi: 10.1111/j.1476-5381.2011.01278.x.
14. Association study with 33 single-nucleotide polymorphisms in 11 candidate genes for hypertension in Chinese. Gu D, etal., Hypertension. 2006 Jun;47(6):1147-54. Epub 2006 Apr 24.
15. Tyrosine hydroxylase deficiency causes progressive encephalopathy and dopa-nonresponsive dystonia. Hoffmann GF, etal., Ann Neurol. 2003;54 Suppl 6:S56-65.
16. Effects of insulin treatment without and with recurrent hypoglycemia on hypoglycemic counterregulation and adrenal catecholamine-synthesizing enzymes in diabetic rats. Inouye KE, etal., Endocrinology. 2006 Apr;147(4):1860-70. Epub 2006 Jan 5.
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PMID:26560700   PMID:26576643   PMID:26658127   PMID:26681446   PMID:26687222   PMID:26687362   PMID:26701169   PMID:26718003   PMID:26724386   PMID:26755703   PMID:26772978   PMID:26857994  
PMID:26871628   PMID:26879466   PMID:26912775   PMID:26961959   PMID:26964886   PMID:26971449   PMID:26985023   PMID:27021360   PMID:27052164   PMID:27063549   PMID:27076429   PMID:27079169  
PMID:27080622   PMID:27143756   PMID:27171818   PMID:27185946   PMID:27209204   PMID:27217161   PMID:27246266   PMID:27315039   PMID:27354364   PMID:27365397   PMID:27407143   PMID:27419218  
PMID:27445711   PMID:27480591   PMID:27568569   PMID:27571008   PMID:27578785   PMID:27595385   PMID:27600842   PMID:27602521   PMID:27648578   PMID:27650319   PMID:27750284   PMID:27771508  
PMID:27810937   PMID:27907249   PMID:27935981   PMID:28009292   PMID:28041852   PMID:28130357   PMID:28133444   PMID:28167615   PMID:28174244   PMID:28411275   PMID:28414329   PMID:28424350  
PMID:28433741   PMID:28459435   PMID:28572455   PMID:28602690   PMID:28615161   PMID:28637693   PMID:28660243   PMID:28684471   PMID:28698373   PMID:28708061   PMID:28718507   PMID:28733161  
PMID:28766996   PMID:28799057   PMID:28800615   PMID:28814342   PMID:28819210   PMID:28831020   PMID:28839197   PMID:28851741   PMID:28893949   PMID:28911199   PMID:28911883   PMID:28942046  
PMID:28958789   PMID:28970231   PMID:28981617   PMID:29031500   PMID:29037208   PMID:29038581   PMID:29043563   PMID:29055051   PMID:29056747   PMID:29086765   PMID:29103613   PMID:29137925  
PMID:29163030   PMID:29192291   PMID:29212953   PMID:29218725   PMID:29248527   PMID:29258872   PMID:29321139   PMID:29341892   PMID:29372256   PMID:29381137   PMID:29404959   PMID:29405286  
PMID:29445148   PMID:29449373   PMID:29472620   PMID:29488099   PMID:29549365   PMID:29581378   PMID:29615468   PMID:29671738   PMID:29672221   PMID:29679559   PMID:29689292   PMID:29716946  
PMID:29748916   PMID:29789702   PMID:29795232   PMID:29807017   PMID:29885287   PMID:29894763   PMID:29922981   PMID:29958804   PMID:29972353   PMID:29972793   PMID:30006573   PMID:30104732  
PMID:30121937   PMID:30127719   PMID:30127721   PMID:30133325   PMID:30143575   PMID:30146491   PMID:30210305   PMID:30224412   PMID:30237243   PMID:30271956   PMID:30282965   PMID:30291164  
PMID:30295607   PMID:30337376   PMID:30352954   PMID:30354182   PMID:30364230   PMID:30413696   PMID:30449655   PMID:30472119   PMID:30485816   PMID:30523254   PMID:30529950   PMID:30542164  
PMID:30655290   PMID:30689541   PMID:30705619   PMID:30713103   PMID:30718509   PMID:30735130   PMID:30740044   PMID:30791216   PMID:30811979   PMID:30819894   PMID:30826183   PMID:30850723  
PMID:30853298   PMID:30885509   PMID:30886406   PMID:30917305   PMID:30930745   PMID:30936473   PMID:30976911   PMID:30991053   PMID:30996124   PMID:30998504   PMID:31002540   PMID:31009113  
PMID:31029728   PMID:31144035   PMID:31178114   PMID:31184376   PMID:31196952   PMID:31200100   PMID:31218818   PMID:31234534   PMID:31241461   PMID:31248728   PMID:31285319   PMID:31291551  
PMID:31300520   PMID:31371375   PMID:31371378   PMID:31420539   PMID:31493975   PMID:31582313   PMID:31609468   PMID:31644367   PMID:31644913   PMID:31704785   PMID:31732722   PMID:31750563  
PMID:31776210   PMID:31781038   PMID:31801063   PMID:31804595   PMID:31839488   PMID:31848220   PMID:31850343   PMID:31852909   PMID:31861806   PMID:31879163   PMID:31974254   PMID:31975688  
PMID:32001620   PMID:32005751   PMID:32017713   PMID:32024956   PMID:32054621   PMID:32094113   PMID:32142670   PMID:32156753   PMID:32161758   PMID:32209486   PMID:32213554   PMID:32243503  
PMID:32253238   PMID:32325033   PMID:32375051   PMID:32383444   PMID:32420617   PMID:32442399   PMID:32499648   PMID:32561725   PMID:32562431   PMID:32562661   PMID:32574559   PMID:32595833  
PMID:32610039   PMID:32679029   PMID:32690615   PMID:32694784   PMID:32822608   PMID:32848620   PMID:32853992   PMID:32877400   PMID:32877676   PMID:32928885   PMID:32935348   PMID:32940375  
PMID:32948232   PMID:33046550   PMID:33053343   PMID:33186530   PMID:33195246   PMID:33208756   PMID:33248443   PMID:33277492   PMID:33288908   PMID:33305180   PMID:33431871   PMID:33462112  
PMID:33476548   PMID:33500353   PMID:33536201   PMID:33547770   PMID:33563725   PMID:33576044   PMID:33600763   PMID:33691777   PMID:33737022   PMID:33744254   PMID:33833454   PMID:33839113  
PMID:33869166   PMID:33887179   PMID:33932356   PMID:33990558   PMID:34004146   PMID:34077727   PMID:34081911   PMID:34100064   PMID:34108486   PMID:34169076   PMID:34189436   PMID:34231420  
PMID:34321999   PMID:34324195   PMID:34370827   PMID:34387544   PMID:34463253   PMID:34494344   PMID:34508581   PMID:34518365   PMID:34525371   PMID:34557485   PMID:34564702   PMID:34580198  
PMID:34592157   PMID:34599305   PMID:34607806   PMID:34679244   PMID:34686322   PMID:34722541   PMID:34758317   PMID:34767545   PMID:34767969   PMID:34782793   PMID:34785571   PMID:34794460  
PMID:34837221   PMID:34851661   PMID:34854381   PMID:34884468   PMID:34905510   PMID:34932943   PMID:35013218   PMID:35042776   PMID:35129674   PMID:35132995   PMID:35156680   PMID:35201886  
PMID:35233469   PMID:35288551   PMID:35377797   PMID:35476632   PMID:35481599   PMID:35496908   PMID:35567414   PMID:35614045   PMID:35643078   PMID:35653588   PMID:35660973   PMID:35700056  
PMID:35714603   PMID:35727300   PMID:35768580   PMID:35793630   PMID:35815410   PMID:35815619   PMID:35875660   PMID:35905741   PMID:35977498   PMID:35997251   PMID:36041430   PMID:36070775  
PMID:36113428   PMID:36122208   PMID:36170850   PMID:36216506   PMID:36237181   PMID:36331996   PMID:36396637   PMID:36409884   PMID:36450244   PMID:36476860   PMID:36526466   PMID:36568970  
PMID:36607262   PMID:36619238   PMID:36674903   PMID:36730190   PMID:36774552   PMID:36797985   PMID:36859533   PMID:36894654   PMID:36897571   PMID:36961815   PMID:37106422   PMID:37108496  
PMID:37192624   PMID:37238632   PMID:37277336   PMID:37318015   PMID:37380765   PMID:37439314   PMID:37537242   PMID:37541195   PMID:37563141   PMID:37625400   PMID:37632750   PMID:37658434  
PMID:37816598   PMID:37857606   PMID:37922904   PMID:37980561   PMID:38003434   PMID:38008788   PMID:38016975   PMID:38025786   PMID:38093006   PMID:38195566   PMID:38198538   PMID:38242116  
PMID:38338764   PMID:38355793   PMID:38451068   PMID:38452762   PMID:38471780   PMID:38488657   PMID:38505753   PMID:38517896   PMID:38546215   PMID:38639409   PMID:38650479   PMID:38706960  
PMID:38811798   PMID:38871457   PMID:38898273   PMID:38912572   PMID:38915692   PMID:38924432   PMID:38981698   PMID:39106106   PMID:39117691   PMID:39138000   PMID:39142280   PMID:39152112  
PMID:39158319   PMID:39223107   PMID:39366958   PMID:39412983   PMID:39429232   PMID:39446486   PMID:39527572   PMID:39569362   PMID:39571902   PMID:39716224   PMID:39742489   PMID:39779976  
PMID:39882631   PMID:39995267   PMID:40083716   PMID:40090880   PMID:40168115   PMID:40205161   PMID:40381613   PMID:40456777  


Genomics

Comparative Map Data
Th
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397142,446,516 - 142,453,732 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7142,446,489 - 142,484,865 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm387142,892,779 - 142,899,995 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7142,892,752 - 142,931,128 (-)Ensemblmm10GRCm38
MGSCv377150,078,681 - 150,085,871 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367142,702,166 - 142,709,356 (-)NCBIMGSCv36mm8
Celera7142,648,392 - 142,655,582 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.06NCBI
TH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38112,163,929 - 2,171,815 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl112,163,929 - 2,171,815 (-)Ensemblhg38GRCh38
GRCh37112,185,159 - 2,193,045 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,141,735 - 2,149,611 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34112,141,735 - 2,149,605NCBI
Celera112,221,752 - 2,229,624 (-)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef111,975,424 - 1,983,299 (-)NCBIHuRef
CHM1_1112,183,941 - 2,191,817 (-)NCBICHM1_1
T2T-CHM13v2.0112,253,295 - 2,261,192 (-)NCBIT2T-CHM13v2.0
Th
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81207,500,959 - 207,508,276 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1207,500,962 - 207,557,227 (-)EnsemblGRCr8
mRatBN7.21198,071,500 - 198,078,832 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1198,071,503 - 198,109,767 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1206,450,387 - 206,457,507 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01213,537,252 - 213,544,373 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01206,211,403 - 206,218,524 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01216,073,034 - 216,080,287 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1216,073,031 - 216,080,287 (-)Ensemblrn6Rnor6.0
Rnor_5.01222,935,462 - 222,942,715 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41203,164,253 - 203,171,506 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1195,642,057 - 195,649,203 (-)NCBICelera
RGSC_v3.11203,317,712 - 203,324,972 (-)NCBI
RH 2.0 Map11080.1RGD
Cytogenetic Map1q41NCBI
Th
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542213,943,552 - 13,951,137 (-)Ensembl
ChiLan1.0NW_00495542213,943,590 - 13,951,102 (-)NCBIChiLan1.0ChiLan1.0
TH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v294,590,095 - 4,597,992 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1113,801,867 - 3,809,764 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0112,204,820 - 2,212,750 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1112,234,095 - 2,242,030 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl112,231,248 - 2,242,433 (-)EnsemblpanPan2panpan1.1
TH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11846,327,136 - 46,334,973 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1846,327,137 - 46,335,602 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1844,936,923 - 44,944,750 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01847,006,609 - 47,014,412 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1847,006,611 - 47,014,441 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11846,455,359 - 46,462,897 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01846,035,687 - 46,043,215 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01846,782,129 - 46,789,967 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Th
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049472,535,447 - 2,543,939 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936794478,614 - 487,061 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936794478,651 - 486,887 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl21,499,620 - 1,506,170 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.121,499,628 - 1,506,180 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111,969,194 - 1,977,263 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11,966,460 - 1,977,218 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603899,163,059 - 99,174,711 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Th
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476715,003,092 - 15,010,154 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476715,003,073 - 15,010,207 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Th
402 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1406
Count of miRNA genes:543
Interacting mature miRNAs:647
Transcripts:ENSMUST00000000219, ENSMUST00000105929, ENSMUST00000123057, ENSMUST00000124951, ENSMUST00000138482, ENSMUST00000140344
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127311241144995196Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127398151144995196Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
14746988Manh63_mmandible shape 63 (mouse)7127735437144995196Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse

Markers in Region
M69200  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv377150,078,722 - 150,078,886UniSTSGRCm37
MGSCv377150,078,761 - 150,078,859UniSTSGRCm37
Celera7142,648,433 - 142,648,597UniSTS
Celera7142,648,472 - 142,648,570UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.2UniSTS
Whitehead/MRC_RH71441.14UniSTS
Whitehead/MRC_RH71441.34UniSTS
Tmem50b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS
cM Map769.2UniSTS
Th  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv377150,078,720 - 150,078,759UniSTSGRCm37
MGSCv377150,082,831 - 150,083,953UniSTSGRCm37
Celera7142,648,431 - 142,648,470UniSTS
Celera7142,652,542 - 142,653,664UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.2UniSTS
cM Map769.2UniSTS
cM Map769.2UniSTS
Th  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS
Th  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS
Th  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS
Th  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS
Th  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,892,815 - 142,892,854UniSTSGRCm38
MGSCv377150,078,720 - 150,078,759UniSTSGRCm37
Celera7142,648,431 - 142,648,470UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.2UniSTS
Th  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,896,926 - 142,898,048UniSTSGRCm38
MGSCv377150,082,831 - 150,083,953UniSTSGRCm37
Celera7142,652,542 - 142,653,664UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.2UniSTS
M69200  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,892,817 - 142,892,981UniSTSGRCm38
MGSCv377150,078,722 - 150,078,886UniSTSGRCm37
Celera7142,648,433 - 142,648,597UniSTS
Cytogenetic Map7F5UniSTS
Whitehead/MRC_RH71441.14UniSTS
M69200  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,892,856 - 142,892,954UniSTSGRCm38
MGSCv377150,078,761 - 150,078,859UniSTSGRCm37
Celera7142,648,472 - 142,648,570UniSTS
Cytogenetic Map7F5UniSTS
Whitehead/MRC_RH71441.34UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000000219   ⟹   ENSMUSP00000000219
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7142,446,489 - 142,453,751 (-)Ensembl
GRCm38.p6 Ensembl7142,892,752 - 142,900,014 (-)Ensembl
Ensembl Acc Id: ENSMUST00000105929   ⟹   ENSMUSP00000101549
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7142,446,535 - 142,484,865 (-)Ensembl
GRCm38.p6 Ensembl7142,892,798 - 142,931,128 (-)Ensembl
Ensembl Acc Id: ENSMUST00000123057   ⟹   ENSMUSP00000122162
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7142,448,169 - 142,453,703 (-)Ensembl
GRCm38.p6 Ensembl7142,894,432 - 142,899,966 (-)Ensembl
Ensembl Acc Id: ENSMUST00000124951   ⟹   ENSMUSP00000122876
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7142,446,703 - 142,453,698 (-)Ensembl
GRCm38.p6 Ensembl7142,892,966 - 142,899,961 (-)Ensembl
Ensembl Acc Id: ENSMUST00000138482   ⟹   ENSMUSP00000123661
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7142,448,141 - 142,450,346 (-)Ensembl
GRCm38.p6 Ensembl7142,894,404 - 142,896,609 (-)Ensembl
Ensembl Acc Id: ENSMUST00000140344   ⟹   ENSMUSP00000115434
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7142,450,335 - 142,484,857 (-)Ensembl
GRCm38.p6 Ensembl7142,896,598 - 142,931,120 (-)Ensembl
RefSeq Acc Id: NM_009377   ⟹   NP_033403
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397142,446,516 - 142,453,732 (-)NCBI
GRCm387142,892,779 - 142,899,995 (-)NCBI
MGSCv377150,078,681 - 150,085,871 (-)RGD
Celera7142,648,392 - 142,655,582 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_033403   ⟸   NM_009377
- UniProtKB: P24529 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000101549   ⟸   ENSMUST00000105929
Ensembl Acc Id: ENSMUSP00000123661   ⟸   ENSMUST00000138482
Ensembl Acc Id: ENSMUSP00000122876   ⟸   ENSMUST00000124951
Ensembl Acc Id: ENSMUSP00000000219   ⟸   ENSMUST00000000219
Ensembl Acc Id: ENSMUSP00000115434   ⟸   ENSMUST00000140344
Ensembl Acc Id: ENSMUSP00000122162   ⟸   ENSMUST00000123057
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P24529-F1-model_v2 AlphaFold P24529 1-498 view protein structure

Promoters
RGD ID:8666229
Promoter ID:EPDNEW_M11145
Type:multiple initiation site
Name:Th_1
Description:Mus musculus tyrosine hydroxylase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387142,899,995 - 142,900,055EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98735 AgrOrtholog
Ensembl Genes ENSMUSG00000000214 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000000219 ENTREZGENE
  ENSMUST00000000219.10 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.800.10 UniProtKB/Swiss-Prot
  3.30.70.260 UniProtKB/Swiss-Prot
InterPro ACT-like_dom_sf UniProtKB/Swiss-Prot
  ArAA_hydroxylase UniProtKB/Swiss-Prot
  ArAA_hydroxylase_Fe/CU_BS UniProtKB/Swiss-Prot
  ArAA_hydroxylase_sf UniProtKB/Swiss-Prot
  Aro-AA_hydroxylase_C_sf UniProtKB/Swiss-Prot
  Aromatic-AA_hydroxylase_C UniProtKB/Swiss-Prot
  Eu_TyrOH_cat UniProtKB/Swiss-Prot
  TH_ACT UniProtKB/Swiss-Prot
  Tyr_3_mOase UniProtKB/Swiss-Prot
  Tyrosine_3-monooxygenase-like UniProtKB/Swiss-Prot
  Tyrosine_hydroxylase_CS UniProtKB/Swiss-Prot
KEGG Report mmu:21823 UniProtKB/Swiss-Prot
MGD MGI:98735 ENTREZGENE
NCBI Gene 21823 ENTREZGENE
PANTHER PTHR11473 UniProtKB/Swiss-Prot
  TYROSINE 3-MONOOXYGENASE UniProtKB/Swiss-Prot
Pfam Biopterin_H UniProtKB/Swiss-Prot
  TH_ACT UniProtKB/Swiss-Prot
  TOH_N UniProtKB/Swiss-Prot
PhenoGen Th PhenoGen
PIRSF PIRSF000336 UniProtKB/Swiss-Prot
PRINTS FYWHYDRXLASE UniProtKB/Swiss-Prot
PROSITE BH4_AAA_HYDROXYL_1 UniProtKB/Swiss-Prot
  BH4_AAA_HYDROXYL_2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55021 UniProtKB/Swiss-Prot
  SSF56534 UniProtKB/Swiss-Prot
UniProt D3Z0B1_MOUSE UniProtKB/TrEMBL
  D6RGQ9_MOUSE UniProtKB/TrEMBL
  E9Q9G5_MOUSE UniProtKB/TrEMBL
  F6VPB5_MOUSE UniProtKB/TrEMBL
  P24529 ENTREZGENE
  Q3UTB3_MOUSE UniProtKB/TrEMBL
  TY3H_MOUSE UniProtKB/Swiss-Prot