Tgfa (transforming growth factor alpha) - Rat Genome Database

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Gene: Tgfa (transforming growth factor alpha) Mus musculus
Analyze
Symbol: Tgfa
Name: transforming growth factor alpha
RGD ID: 11411
MGI Page MGI
Description: Enables receptor ligand activity and transmembrane receptor protein tyrosine kinase activator activity. Involved in epidermal growth factor receptor signaling pathway and hepatocyte proliferation. Acts upstream of or within several processes, including angiogenesis; mammary gland alveolus development; and positive regulation of peptidyl-tyrosine phosphorylation. Is active in extracellular space. Is expressed in several structures, including alimentary system; brain; cranium; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in gastroenteritis and pancreatic cancer. Orthologous to human TGFA (transforming growth factor alpha).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: protransforming growth factor alpha; transforming growth factor-alpha; wa-1; wa1; waved 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39686,172,020 - 86,252,726 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl686,172,205 - 86,252,701 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38686,195,038 - 86,275,744 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl686,195,223 - 86,275,719 (+)Ensemblmm10GRCm38
MGSCv37686,145,245 - 86,225,443 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36686,161,050 - 86,240,791 (+)NCBIMGSCv36mm8
Celera688,129,264 - 88,209,219 (+)NCBICelera
Cytogenetic Map6D1NCBI
cM Map637.62NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(R)-lipoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,3-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-amino-6-diazo-5-oxohexanoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-tert-butylhydroquinone  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
4-nonylphenol  (EXP)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetylsalicylic acid  (ISO)
acteoside  (ISO)
adenosine  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
auranofin  (ISO)
batimastat  (ISO)
bazedoxifene  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-D-glucosamine  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bromocriptine  (ISO)
bucladesine  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
butane-2,3-dione  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (EXP)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
capsaicin  (ISO)
carvacrol  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corn oil  (ISO)
crizotinib  (ISO)
Cuprizon  (ISO)
cycloheximide  (ISO)
cyproconazole  (EXP)
D-glucose  (ISO)
dexamethasone  (ISO)
dextromethorphan  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP,ISO)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimethylarsinic acid  (ISO)
Diosbulbin B  (EXP)
dioxygen  (ISO)
dizocilpine maleate  (EXP)
doxorubicin  (ISO)
epoxiconazole  (EXP)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
etoposide  (ISO)
Evodiamine  (ISO)
ferric oxide  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furosemide  (ISO)
gefitinib  (EXP,ISO)
genistein  (ISO)
gentamycin  (ISO)
glucose  (ISO)
hexachlorobenzene  (EXP)
hydrogen chloride  (ISO)
irinotecan  (ISO)
iron(III) nitrilotriacetate  (ISO)
isobutanol  (ISO)
kaempferol  (ISO)
KN-93  (ISO)
lansoprazole  (ISO)
leflunomide  (ISO)
lidocaine  (EXP)
limonene  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (ISO)
lycopene  (ISO)
manganese(II) chloride  (EXP)
marimastat  (ISO)
melatonin  (ISO)
melittin  (ISO)
mercury dichloride  (ISO)
metamizole sodium  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
nickel sulfate  (EXP,ISO)
nitrofurazone  (ISO)
okadaic acid  (ISO)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (ISO)
PD 168393  (ISO)
Pentoxifylline  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
PHA-665752  (ISO)
phenytoin  (EXP)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phorone  (ISO)
pifithrin-alpha hydrobromide  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
poly(propylene imine) macromolecule  (ISO)
probenecid  (ISO)
progesterone  (ISO)
propiconazole  (EXP)
pyrrolidine dithiocarbamate  (ISO)
pyrvinium  (ISO)
quercetin  (ISO)
quinomethionate  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
riddelliine  (ISO)
rottlerin  (ISO)
Ruscogenin  (ISO)
rutin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
sarin  (ISO)
serpentine asbestos  (EXP,ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
Sulpyrine  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thiram  (ISO)
titanium dioxide  (EXP)
trans-piceid  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tyrphostin AG 1478  (ISO)
valproic acid  (EXP,ISO)
vemurafenib  (ISO)
vinclozolin  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adipose tissue distribution  (IAGP)
abnormal anterior eye segment morphology  (IAGP)
abnormal branching of the mammary ductal tree  (IAGP)
abnormal coat appearance  (IEA)
abnormal coat/ hair morphology  (IEA)
abnormal cornea stroma development  (IAGP)
abnormal eye morphology  (IAGP)
abnormal eyelid aperture  (IAGP)
abnormal eyelid development  (IAGP)
abnormal eyelid morphology  (IAGP)
abnormal hair follicle development  (IEA)
abnormal hair follicle morphology  (IAGP)
abnormal hair follicle orientation  (IAGP)
abnormal hair medulla  (IAGP)
abnormal hair shaft morphology  (IAGP)
abnormal hair texture  (IEA)
abnormal ileum morphology  (IAGP)
abnormal intestinal goblet cell morphology  (IAGP)
abnormal iris morphology  (IAGP)
abnormal mammary gland growth during pregnancy  (IAGP)
abnormal small intestine crypts of Lieberkuhn morphology  (IAGP)
abnormal small intestine morphology  (IAGP)
abnormal vibrissa morphology  (IEA)
abnormal zigzag hair morphology  (IEA)
absent Descemet membrane  (IAGP)
absent eye anterior chamber  (IAGP)
alopecia  (IAGP)
cataract  (IAGP)
conjunctivitis  (IAGP)
cornea opacity  (IAGP)
cornea scarring  (IAGP)
curly vibrissae  (IAGP)
decreased body size  (IEA)
decreased body weight  (IAGP)
decreased guard hair length  (IEA)
dermatitis  (IAGP)
disheveled coat  (IAGP)
duodenal lesions  (IAGP)
eyelid hyperplasia  (IAGP)
eyelids open at birth  (IAGP)
failure of eyelid fusion  (IAGP)
hypolactation  (IAGP)
increased cornea stroma thickness  (IAGP)
increased curvature of hairs  (IAGP)
increased incidence of corneal inflammation  (IAGP)
keratoconjunctivitis  (IAGP)
kinked vibrissae  (IAGP)
Meibomian gland hypoplasia  (IAGP)
microphthalmia  (IAGP)
orbicularis oculi muscle hypoplasia  (IAGP)
postnatal growth retardation  (IAGP)
retina neovascularization  (IAGP)
ruptured lens capsule  (IAGP)
small mandible  (IAGP)
spontaneous skin ulceration  (IAGP)
waved hair  (IAGP)
wavy vibrissae  (IEA)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis. Appleton CT, etal., Arthritis Rheum. 2007 Nov;56(11):3693-705.
2. Overexpression of transforming growth factor-alpha and epidermal growth factor-receptor in idiopathic pulmonary fibrosis. Baughman RP, etal., Sarcoidosis Vasc Diffuse Lung Dis. 1999 Mar;16(1):57-61.
3. A novel inhibitor of tumor necrosis factor-alpha converting enzyme ameliorates polycystic kidney disease. Dell KM, etal., Kidney Int. 2001 Oct;60(4):1240-8.
4. Hepatocellular neoplasms induced by low-number pancreatic islet transplants in streptozotocin diabetic rats. Dombrowski F, etal., Am J Pathol. 1997 Mar;150(3):1071-87.
5. Transforming growth factor-alpha induces neurogenesis and behavioral improvement in a chronic stroke model. Guerra-Crespo M, etal., Neuroscience. 2009 May 5;160(2):470-83. Epub 2009 Feb 25.
6. Immunolocalization of transforming growth factor alpha and epidermal growth factor receptor in lungs of patients with cystic fibrosis. Hardie WD, etal., Pediatr Dev Pathol. 1999 Sep-Oct;2(5):415-23.
7. Control of the epidermal growth factor receptor and its ligands during renal injury. Hise MK, etal., Nephron. 2001 May;88(1):71-9.
8. Possible tumor development from double positive foci for TGF-alpha and GST-P observed in early stages on rat hepatocarcinogenesis. Kitano M, etal., Cancer Sci. 2006 Jun;97(6):478-83.
9. Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor alpha. Korc M, etal., J Clin Invest. 1992 Oct;90(4):1352-60.
10. Transient induction of TGF-alpha disrupts lung morphogenesis, causing pulmonary disease in adulthood. Le Cras TD, etal., Am J Physiol Lung Cell Mol Physiol. 2004 Oct;287(4):L718-29. Epub 2004 Apr 16.
11. Transforming growth factor alpha immunoreactivity in human gallbladder and extrahepatic biliary tract tumours. Lee CS Eur J Surg Oncol. 1998 Feb;24(1):38-42.
12. Elevated transforming growth factor-alpha levels in bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome. Madtes DK, etal., Am J Respir Crit Care Med. 1998 Aug;158(2):424-30.
13. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
14. MGDs mouse GO annotations MGD data from the GO Consortium
15. MGD IEA MGD IEA
16. Evidence for repatterning of the gastric fundic epithelium associated with Menetrier's disease and TGFalpha overexpression. Nomura S, etal., Gastroenterology. 2005 May;128(5):1292-305.
17. Molecular genetics of malignant insulinoma. Pavelic K, etal., Anticancer Res. 1996 Jul-Aug;16(4A):1707-17.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
20. Mouse MP Annotation Import Pipeline RGD automated import pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Autocrine, paracrine and juxtacrine signaling by EGFR ligands. Singh AB and Harris RC, Cell Signal. 2005 Oct;17(10):1183-93.
24. Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN. Siveke JT, etal., Cancer Cell. 2007 Sep;12(3):266-79.
25. Transforming growth factor-alpha stimulates enterocyte proliferation and accelerates intestinal recovery following methotrexate-induced intestinal mucositis in a rat and a cell culture model. Sukhotnik I, etal., Pediatr Surg Int. 2008 Dec;24(12):1303-11.
26. Pancreatic cancer: molecular pathogenesis and new therapeutic targets. Wong HH and Lemoine NR, Nat Rev Gastroenterol Hepatol. 2009 Jul;6(7):412-22. Epub 2009 Jun 9.
Additional References at PubMed
PMID:287034   PMID:1270792   PMID:1290451   PMID:1316084   PMID:1393573   PMID:1394122   PMID:1420315   PMID:1426645   PMID:1442934   PMID:1578263   PMID:1693546   PMID:1709129  
PMID:2040452   PMID:2161707   PMID:2350785   PMID:2887485   PMID:2898504   PMID:3138071   PMID:4015615   PMID:6088071   PMID:6254071   PMID:6315706   PMID:7507352   PMID:7573353  
PMID:7590736   PMID:7600984   PMID:7601910   PMID:7640654   PMID:7641211   PMID:7654366   PMID:7656413   PMID:7664668   PMID:7669729   PMID:7678348   PMID:7720037   PMID:7724532  
PMID:7728756   PMID:7738386   PMID:7744960   PMID:7752576   PMID:7753792   PMID:7765502   PMID:7774940   PMID:7819129   PMID:7819439   PMID:7841657   PMID:7867496   PMID:7881126  
PMID:7923571   PMID:7987303   PMID:8027772   PMID:8083581   PMID:8100806   PMID:8137281   PMID:8163670   PMID:8188273   PMID:8266997   PMID:8268657   PMID:8290278   PMID:8299590  
PMID:8395365   PMID:8446583   PMID:8476349   PMID:8477444   PMID:8477445   PMID:8566750   PMID:8597531   PMID:8600155   PMID:8701981   PMID:8702723   PMID:8751373   PMID:8761297  
PMID:8816486   PMID:8877107   PMID:8906120   PMID:9022052   PMID:9129233   PMID:9168935   PMID:9169087   PMID:9203584   PMID:9261927   PMID:9264259   PMID:9287974   PMID:9315905  
PMID:9675004   PMID:9792801   PMID:9858678   PMID:10051620   PMID:10196526   PMID:10226062   PMID:10331984   PMID:10349636   PMID:10362794   PMID:10375383   PMID:10380881   PMID:10521784  
PMID:10547072   PMID:10552925   PMID:10569807   PMID:10631174   PMID:10635333   PMID:10700187   PMID:10727800   PMID:10741459   PMID:10918574   PMID:10926756   PMID:10942533   PMID:11042159  
PMID:11076861   PMID:11159375   PMID:11159909   PMID:11212255   PMID:11217851   PMID:11280770   PMID:11358795   PMID:11399798   PMID:11415940   PMID:11423703   PMID:11438495   PMID:11518516  
PMID:11597899   PMID:11641778   PMID:11681850   PMID:11725690   PMID:11738552   PMID:11795938   PMID:11896982   PMID:11954676   PMID:12183685   PMID:12368216   PMID:12394184   PMID:12399441  
PMID:12466851   PMID:12477932   PMID:12520078   PMID:12560605   PMID:12866207   PMID:12878679   PMID:13358719   PMID:14514962   PMID:14660483   PMID:14964469   PMID:14998491   PMID:15226823  
PMID:15366372   PMID:15375216   PMID:15385618   PMID:15456865   PMID:15572151   PMID:15652357   PMID:15774823   PMID:15799028   PMID:15811345   PMID:15829639   PMID:15856015   PMID:15958512  
PMID:15965977   PMID:15994019   PMID:16079309   PMID:16141072   PMID:16141073   PMID:16141218   PMID:16316011   PMID:16510872   PMID:16565509   PMID:16602821   PMID:16727441   PMID:16820093  
PMID:16857964   PMID:17071603   PMID:17289271   PMID:17334393   PMID:17361012   PMID:17418408   PMID:17468132   PMID:17484876   PMID:17638868   PMID:17881575   PMID:18069687   PMID:18156207  
PMID:18310091   PMID:18448089   PMID:18485343   PMID:18701439   PMID:18825967   PMID:18912545   PMID:19230855   PMID:19500387   PMID:19749746   PMID:19903783   PMID:20638776   PMID:20660988  
PMID:20685999   PMID:20713502   PMID:20843830   PMID:20930145   PMID:21041656   PMID:21097655   PMID:21145869   PMID:21183591   PMID:21187124   PMID:21267068   PMID:21512138   PMID:21837653  
PMID:21873635   PMID:21946538   PMID:22035642   PMID:22575362   PMID:22639808   PMID:22682244   PMID:23029012   PMID:23386589   PMID:24014668   PMID:24043783   PMID:24048703   PMID:24199692  
PMID:24227310   PMID:24825892   PMID:24952961   PMID:25402175   PMID:25641696   PMID:26073538   PMID:26363126   PMID:26764350   PMID:27021937   PMID:27264103   PMID:27457421   PMID:28249836  
PMID:28305731   PMID:29959129   PMID:30143575   PMID:30834805   PMID:32561725   PMID:32668000   PMID:33406080   PMID:34321999   PMID:35442545   PMID:36206490   PMID:36764291   PMID:36915679  


Genomics

Comparative Map Data
Tgfa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39686,172,020 - 86,252,726 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl686,172,205 - 86,252,701 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38686,195,038 - 86,275,744 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl686,195,223 - 86,275,719 (+)Ensemblmm10GRCm38
MGSCv37686,145,245 - 86,225,443 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36686,161,050 - 86,240,791 (+)NCBIMGSCv36mm8
Celera688,129,264 - 88,209,219 (+)NCBICelera
Cytogenetic Map6D1NCBI
cM Map637.62NCBI
TGFA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38270,447,284 - 70,553,826 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl270,447,284 - 70,554,193 (-)Ensemblhg38GRCh38
GRCh37270,674,416 - 70,780,958 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36270,527,924 - 70,634,613 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34270,586,073 - 70,692,585NCBI
Celera270,525,095 - 70,631,786 (-)NCBICelera
Cytogenetic Map2p13.3NCBI
HuRef270,410,567 - 70,517,904 (-)NCBIHuRef
CHM1_1270,602,969 - 70,710,469 (-)NCBICHM1_1
T2T-CHM13v2.0270,458,007 - 70,564,581 (-)NCBIT2T-CHM13v2.0
Tgfa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84120,175,549 - 120,258,342 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4120,175,593 - 120,258,339 (+)EnsemblGRCr8
mRatBN7.24118,618,043 - 118,700,897 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4118,618,269 - 118,700,894 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4124,090,369 - 124,173,637 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04119,865,117 - 119,948,389 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04118,489,559 - 118,572,638 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04117,961,877 - 118,045,923 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4117,962,319 - 118,046,344 (+)Ensemblrn6Rnor6.0
Rnor_5.04182,534,161 - 182,616,713 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44120,355,649 - 120,437,772 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4107,591,450 - 107,673,528 (+)NCBICelera
RGSC_v3.14120,600,129 - 120,682,257 (+)NCBI
RH 3.4 Map4688.3RGD
Cytogenetic Map4q34NCBI
Tgfa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542414,616,259 - 14,710,183 (+)Ensembl
ChiLan1.0NW_00495542414,616,390 - 14,709,723 (+)NCBIChiLan1.0ChiLan1.0
TGFA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21255,834,831 - 55,941,709 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A55,838,772 - 55,945,653 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A70,510,727 - 70,617,628 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A71,625,196 - 71,731,461 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A71,625,196 - 71,731,461 (-)EnsemblpanPan2panpan1.1
TGFA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11068,915,671 - 68,957,027 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1068,799,798 - 68,879,353 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01069,935,210 - 70,012,287 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1069,934,119 - 70,022,283 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11069,652,504 - 69,732,094 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01069,914,727 - 69,994,269 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01070,213,444 - 70,290,872 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tgfa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629213,812,443 - 13,910,943 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649114,657,100 - 14,758,848 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649114,659,089 - 14,758,614 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TGFA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl371,948,137 - 72,050,474 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1371,948,232 - 72,054,257 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2375,409,715 - 75,437,890 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TGFA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11436,545,641 - 36,654,213 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1436,545,875 - 36,648,237 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604575,360,438 - 75,475,321 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tgfa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247622,832,078 - 2,937,318 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247622,832,073 - 2,941,150 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Tgfa
4307 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1384
Count of miRNA genes:651
Interacting mature miRNAs:829
Transcripts:ENSMUST00000032066
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683690851146954059Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671958006105958152Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67707698389976982Mouse
10412119Stv_mstriatal volumne (mouse)Not determined660026991100026967Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671958006105958152Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67797698396976961Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648696934125336963Mouse
12792979Fbmd2_mfemoral bone mineral density 2, females only (mouse)675026989115026943Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67552133992584431Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67552133994202936Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65842456692424693Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671552042105552160Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67129960593441074Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64529099387403016Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648703490125333748Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7129960586252701Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5435041188356155Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675424566104480516Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65851741692517416Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63864656092584431Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684099474118099474Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675584287109584431Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670402880104403016Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652138693116132228Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670402880104403016Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676440930110441074Mouse
15039373Adip28_madiposity 28 (mouse)65628519490285194Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65628519490285194Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66346172197461888Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675693484109693678Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666690851100691013Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670402880104403016Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681476981102176961Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67552133994202936Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66003466394034782Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678606487121092347Mouse

Markers in Region
Tgfa  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37686,220,024 - 86,221,466UniSTSGRCm37
Celera688,203,807 - 88,205,249UniSTS
Cytogenetic Map6D1UniSTS
cM Map635.8UniSTS
cM Map635.8UniSTS
stSG633446  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38686,257,033 - 86,258,713UniSTSGRCm38
MGSCv37686,207,027 - 86,208,707UniSTSGRCm37
Celera688,190,822 - 88,192,502UniSTS
Cytogenetic Map6D1UniSTS
cM Map635.8UniSTS
Tgfa  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6D1UniSTS
Tgfa  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6D1UniSTS
cM Map635.8UniSTS
Tgfa  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6D1UniSTS
cM Map635.8UniSTS
Tgfa  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38686,270,030 - 86,271,472UniSTSGRCm38
MGSCv37686,220,024 - 86,221,466UniSTSGRCm37
Celera688,203,807 - 88,205,249UniSTS
Cytogenetic Map6D1UniSTS
cM Map635.8UniSTS
Tgfa  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6D1UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000032066   ⟹   ENSMUSP00000032066
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl686,172,205 - 86,252,701 (+)Ensembl
GRCm38.p6 Ensembl686,195,223 - 86,275,719 (+)Ensembl
Ensembl Acc Id: ENSMUST00000192058   ⟹   ENSMUSP00000141395
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl686,172,372 - 86,249,011 (+)Ensembl
GRCm38.p6 Ensembl686,195,390 - 86,272,029 (+)Ensembl
Ensembl Acc Id: ENSMUST00000193710
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl686,172,233 - 86,186,896 (+)Ensembl
GRCm38.p6 Ensembl686,195,251 - 86,209,914 (+)Ensembl
Ensembl Acc Id: ENSMUST00000194449
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl686,188,576 - 86,249,201 (+)Ensembl
GRCm38.p6 Ensembl686,211,594 - 86,272,219 (+)Ensembl
RefSeq Acc Id: NM_001403118   ⟹   NP_001390047
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39686,172,204 - 86,252,726 (+)NCBI
RefSeq Acc Id: NM_031199   ⟹   NP_112476
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39686,172,204 - 86,252,726 (+)NCBI
GRCm38686,195,222 - 86,275,744 (+)NCBI
MGSCv37686,145,245 - 86,225,443 (+)RGD
Celera688,129,264 - 88,209,219 (+)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030255312   ⟹   XP_030111172
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39686,172,020 - 86,248,482 (+)NCBI
GRCm38686,195,038 - 86,271,500 (+)NCBI
Sequence:
RefSeq Acc Id: NP_112476   ⟸   NM_031199
- Peptide Label: isoform 1 preproprotein
- UniProtKB: P48030 (UniProtKB/Swiss-Prot),   Q545E4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030111172   ⟸   XM_030255312
- Peptide Label: isoform X1
Ensembl Acc Id: ENSMUSP00000032066   ⟸   ENSMUST00000032066
Ensembl Acc Id: ENSMUSP00000141395   ⟸   ENSMUST00000192058
RefSeq Acc Id: NP_001390047   ⟸   NM_001403118
- Peptide Label: isoform 2 preproprotein
Protein Domains
EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48030-F1-model_v2 AlphaFold P48030 1-159 view protein structure

Promoters
RGD ID:6840064
Promoter ID:MM_KWN:46722
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Liver,   Lung
Transcripts:NM_031199,   UC009CRJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36686,145,156 - 86,145,656 (+)MPROMDB
RGD ID:6890268
Promoter ID:EPDNEW_M8585
Type:initiation region
Name:Tgfa_1
Description:Mus musculus transforming growth factor alpha , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8586  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38686,195,222 - 86,195,282EPDNEW
RGD ID:6890270
Promoter ID:EPDNEW_M8586
Type:multiple initiation site
Name:Tgfa_2
Description:Mus musculus transforming growth factor alpha , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8585  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38686,195,450 - 86,195,510EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98724 AgrOrtholog
Ensembl Genes ENSMUSG00000029999 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000032066 ENTREZGENE
  ENSMUST00000032066.13 UniProtKB/Swiss-Prot
Gene3D-CATH Laminin UniProtKB/Swiss-Prot
InterPro EGF-like_dom UniProtKB/Swiss-Prot
KEGG Report mmu:21802 UniProtKB/Swiss-Prot
MGD MGI:98724 ENTREZGENE
NCBI Gene 21802 ENTREZGENE
PANTHER PROTRANSFORMING GROWTH FACTOR ALPHA UniProtKB/Swiss-Prot
  PTHR10740 UniProtKB/Swiss-Prot
PhenoGen Tgfa PhenoGen
PRINTS EGFTGF UniProtKB/Swiss-Prot
PROSITE EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
UniProt A0A0A6YW49_MOUSE UniProtKB/TrEMBL
  P48030 ENTREZGENE
  Q545E4 ENTREZGENE, UniProtKB/TrEMBL
  TGFA_MOUSE UniProtKB/Swiss-Prot