Tg (thyroglobulin) - Rat Genome Database

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Gene: Tg (thyroglobulin) Mus musculus
Analyze
Symbol: Tg
Name: thyroglobulin
RGD ID: 11408
MGI Page MGI
Description: Enables identical protein binding activity. Involved in thyroid hormone generation. Acts upstream of or within iodide transport; regulation of myelination; and thyroid hormone metabolic process. Located in extracellular space. Is expressed in thyroid gland; thyroid gland follicle; thyroid gland left lobe colloid-filled follicles; thyroid gland lobe; and thyroid gland right lobe colloid-filled follicles. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in autoimmune disease of endocrine system (multiple); goiter; liver disease (multiple); and thyroid dyshormonogenesis 3. Orthologous to human TG (thyroglobulin).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cog; congenital goiter; MGC117699; Tgn
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   Fob3_m  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391566,542,606 - 66,722,570 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1566,542,602 - 66,722,570 (+)EnsemblGRCm39 Ensembl
GRCm381566,670,754 - 66,850,721 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1566,670,753 - 66,850,721 (+)EnsemblGRCm38mm10GRCm38
MGSCv371566,502,332 - 66,682,283 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361566,500,461 - 66,680,276 (+)NCBIMGSCv36mm8
Celera1568,203,057 - 68,383,403 (+)NCBICelera
Cytogenetic Map15D2NCBI
cM Map1529.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (EXP,ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bromobenzene  (ISO)
buta-1,3-diene  (EXP)
C60 fullerene  (ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
daidzein  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
diiodine  (EXP)
disodium selenite  (ISO)
efavirenz  (ISO)
endosulfan  (ISO)
Ethylenethiourea  (EXP)
fipronil  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glycidol  (ISO)
glyphosate  (ISO)
lovastatin  (ISO)
malathion  (ISO)
methimazole  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
mono(5-carboxy-2-ethylpentyl) phthalate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
nevirapine  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
ozone  (ISO)
paracetamol  (EXP)
PCB138  (ISO)
perchlorate  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (ISO)
pioglitazone  (EXP)
potassium iodide  (ISO)
prostaglandin D2  (ISO)
prostaglandin J2  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP,ISO)
sodium nitrate  (ISO)
sodium perchlorate  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
titanium dioxide  (EXP)
trimellitic anhydride  (EXP)
triptonide  (EXP)
valproic acid  (ISO)
vemurafenib  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal auditory brainstem response  (IEA)
abnormal myelination  (IAGP)
abnormal pelvic girdle bone morphology  (IEA)
abnormal thyroid follicle morphology  (IEA)
abnormal thyroid follicular cell morphology  (IEA)
anemia  (IAGP)
decreased B cell number  (IEA)
decreased B-2 B cell number  (IEA)
decreased body fat mass  (IEA)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased brain weight  (IAGP)
decreased circulating thyroxine level  (IAGP)
decreased circulating triiodothyronine level  (IAGP)
decreased exploration in new environment  (IEA)
decreased hematocrit  (IAGP)
decreased IgE level  (IEA)
decreased lean body mass  (IEA)
decreased locomotor activity  (IEA)
decreased vertical activity  (IEA)
disproportionate dwarf  (IEA)
enlarged thyroid gland  (IAGP)
improved glucose tolerance  (IEA)
increased alpha-beta T cell number  (IEA)
increased B-1a cell number  (IEA)
increased bone mineral content  (IEA)
increased CD4-positive, alpha-beta T cell number  (IEA)
increased CD8-positive, alpha-beta T cell number  (IEA)
increased central memory CD4-positive, alpha-beta T cell number  (IEA)
increased circulating thyroid-stimulating hormone level  (IAGP)
increased fasting circulating glucose level  (IEA)
increased grip strength  (IEA)
increased growth rate  (IEA)
increased IgE level  (IEA)
increased macrophage cell number  (IEA)
increased susceptibility to induced colitis  (IEA)
male infertility  (IEA)
postnatal growth retardation  (IAGP)
prolonged RR interval  (IEA)
short femur  (IEA)
short tibia  (IEA)
References

References - curated
# Reference Title Reference Citation
1. Multiple SNPs in intron 41 of thyroglobulin gene are associated with autoimmune thyroid disease in the Japanese population. Ban Y, etal., PLoS One. 2012;7(5):e37501. doi: 10.1371/journal.pone.0037501. Epub 2012 May 25.
2. Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease. Ban Y, etal., Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15119-24. Epub 2003 Dec 1.
3. Thyroglobulin polymorphisms in Tunisian patients with autoimmune thyroid diseases (AITD). Belguith-Maalej S, etal., Immunobiology. 2008;213(7):577-83. doi: 10.1016/j.imbio.2008.01.004. Epub 2008 Mar 4.
4. The association of non-alcoholic fatty liver disease with thyroid peroxidase and thyroglobulin antibody: A new insight from SPECT-China study. Chen Y, etal., Autoimmunity. 2018 Aug;51(5):238-244. doi: 10.1080/08916934.2018.1488968. Epub 2018 Jul 17.
5. Thyroid antibodies and tumor necrosis factor-alpha in patients with benign thyroid nodules treated by percutaneous ethanol injections. Fronio G, etal., Int J Clin Pharmacol Ther. 2005 Jan;43(1):12-6. doi: 10.5414/cpp43012.
6. Rescue from dwarfism by thyroid function compensation in rdw rats. Furudate S, etal., Exp Anim. 2005 Oct;54(5):455-60. doi: 10.1538/expanim.54.455.
7. Serum thyroglobulin in acute and chronic liver disease. Hegedüs L, etal., Clin Endocrinol (Oxf). 1983 Aug;19(2):231-7. doi: 10.1111/j.1365-2265.1983.tb02985.x.
8. A novel missense mutation (G2320R) in thyroglobulin causes hypothyroidism in rdw rats. Hishinuma A, etal., Endocrinology 2000 Nov;141(11):4050-5.
9. Association between a C/T polymorphism in exon 33 of the thyroglobulin gene is associated with relapse of Graves' hyperthyroidism after antithyroid withdrawal in Taiwanese. Hsiao JY, etal., J Clin Endocrinol Metab. 2007 Aug;92(8):3197-201. Epub 2007 Jun 5.
10. A 3' splice site mutation in the thyroglobulin gene responsible for congenital goiter with hypothyroidism. Ieiri T, etal., J Clin Invest. 1991 Dec;88(6):1901-5.
11. cDNA immunization of mice with human thyroglobulin generates both humoral and T cell responses: a novel model of thyroid autoimmunity. Jacobson EM, etal., PLoS One. 2011 Apr 29;6(4):e19200. doi: 10.1371/journal.pone.0019200.
12. Efficacy of HLA-DRB1 *03:01 and H2E transgenic mouse strains to correlate pathogenic thyroglobulin epitopes for autoimmune thyroiditis. Kong YC, etal., J Autoimmun. 2011 Jun 17.
13. [rdw rats, a new hereditary dwarf model in the rat]. Koto M, etal., Jikken Dobutsu. 1988 Jan;37(1):21-30.
14. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
15. MGDs mouse GO annotations MGD data from the GO Consortium
16. MGD IEA MGD IEA
17. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. Mouse MP Annotation Import Pipeline RGD automated import pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Missing secretory granules, dilated endoplasmic reticulum, and nuclear dislocation in the thyroid gland of rdw rats with hereditary dwarfism. Sakai Y, etal., Anat Rec. 2000 May 1;259(1):60-6.
25. Increased sensitivity of a new assay for anti-thyroglobulin antibody detection in patients with autoimmune thyroid disease. Sapin R, etal., Clin Biochem. 2003 Nov;36(8):611-6.
26. Analysis of the spectrotypes of autoantibodies against thyroglobulin in two rat models of autoimmune thyroiditis. Stott DI, etal., Clin Exp Immunol. 1988 Aug;73(2):269-75.
27. Soy extracts suppressed iodine uptake and stimulated the production of autoimmunogen in rat thyrocytes. Tran L, etal., Exp Biol Med (Maywood). 2013 Jun;238(6):623-30. doi: 10.1177/1535370213489488.
28. Effect of therapy on serum thyroglobulin levels in patients with Graves' disease. Uller RP and Van Herle AJ, J Clin Endocrinol Metab. 1978 May;46(5):747-55.
Additional References at PubMed
PMID:1311971   PMID:1354638   PMID:1358803   PMID:1386365   PMID:1508304   PMID:1632635   PMID:1673105   PMID:1696305   PMID:1794046   PMID:1889815   PMID:2165966   PMID:2630190  
PMID:2882514   PMID:2892786   PMID:3392390   PMID:3416641   PMID:3803305   PMID:7743923   PMID:7959737   PMID:8094075   PMID:8258699   PMID:8268655   PMID:8314081   PMID:8482578  
PMID:8507976   PMID:8597630   PMID:8626865   PMID:8636228   PMID:8662221   PMID:8672132   PMID:8879453   PMID:9214635   PMID:9271678   PMID:9344706   PMID:9520319   PMID:9590297  
PMID:9697704   PMID:9707574   PMID:10613847   PMID:11714850   PMID:11961095   PMID:12391254   PMID:12432093   PMID:12477932   PMID:12782676   PMID:12815622   PMID:15111333   PMID:15231702  
PMID:15782199   PMID:16150900   PMID:16331648   PMID:16342117   PMID:16547286   PMID:16964447   PMID:17103415   PMID:17164259   PMID:17332529   PMID:17495424   PMID:17916655   PMID:17967808  
PMID:18687776   PMID:18952847   PMID:19010321   PMID:19235715   PMID:19276074   PMID:19389367   PMID:19716808   PMID:19786540   PMID:20160132   PMID:20194734   PMID:20236260   PMID:20353937  
PMID:20375239   PMID:20573721   PMID:20578903   PMID:20687399   PMID:20697379   PMID:21266507   PMID:21267068   PMID:21345181   PMID:21364918   PMID:21677750   PMID:21816825   PMID:21873635  
PMID:22132122   PMID:22264824   PMID:22724066   PMID:23563309   PMID:23690091   PMID:23707896   PMID:24265449   PMID:24879795   PMID:25127920   PMID:25490145   PMID:26395490   PMID:27068110  
PMID:27384679   PMID:29361553   PMID:29440273   PMID:29518331   PMID:30446499   PMID:31582725   PMID:32241916   PMID:32325033   PMID:32360566   PMID:33905568   PMID:34975747   PMID:35618019  
PMID:37345654   PMID:37964961  


Genomics

Comparative Map Data
Tg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391566,542,606 - 66,722,570 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1566,542,602 - 66,722,570 (+)EnsemblGRCm39 Ensembl
GRCm381566,670,754 - 66,850,721 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1566,670,753 - 66,850,721 (+)EnsemblGRCm38mm10GRCm38
MGSCv371566,502,332 - 66,682,283 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361566,500,461 - 66,680,276 (+)NCBIMGSCv36mm8
Celera1568,203,057 - 68,383,403 (+)NCBICelera
Cytogenetic Map15D2NCBI
cM Map1529.3NCBI
TG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388132,866,958 - 133,134,899 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8132,866,958 - 133,134,903 (+)EnsemblGRCh38hg38GRCh38
GRCh378133,879,203 - 134,147,143 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368133,948,387 - 134,216,325 (+)NCBINCBI36Build 36hg18NCBI36
Build 348133,948,386 - 134,216,325NCBI
Celera8130,055,026 - 130,324,401 (+)NCBICelera
Cytogenetic Map8q24.22NCBI
HuRef8129,197,896 - 129,466,621 (+)NCBIHuRef
CHM1_18133,919,854 - 134,187,744 (+)NCBICHM1_1
T2T-CHM13v2.08133,990,136 - 134,258,223 (+)NCBIT2T-CHM13v2.0
Tg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87100,307,349 - 100,492,246 (+)NCBIGRCr8
mRatBN7.2798,418,293 - 98,603,210 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl798,418,293 - 98,603,210 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7100,178,793 - 100,363,327 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07102,380,454 - 102,564,998 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07102,299,801 - 102,484,333 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07107,467,260 - 107,652,897 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7107,467,260 - 107,652,899 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07107,399,165 - 107,602,400 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47104,035,776 - 104,220,754 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17104,070,005 - 104,254,984 (+)NCBI
Celera794,970,745 - 95,154,294 (+)NCBICelera
Cytogenetic Map7q33NCBI
Tg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554617,487,322 - 7,703,363 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554617,487,268 - 7,703,458 (+)NCBIChiLan1.0ChiLan1.0
TG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27150,253,626 - 150,524,100 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18125,768,221 - 126,038,630 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08129,519,431 - 129,789,699 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18132,495,516 - 132,764,918 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8132,495,516 - 132,764,918 (+)Ensemblpanpan1.1panPan2
TG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11329,350,726 - 29,597,908 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1329,350,688 - 29,598,040 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1329,323,440 - 29,571,872 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01329,705,326 - 29,954,007 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1329,705,417 - 29,953,970 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11329,431,959 - 29,680,604 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01329,532,359 - 29,781,038 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01329,844,402 - 30,129,590 (+)NCBIUU_Cfam_GSD_1.0
Tg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053038,759,400 - 8,970,073 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493647016,185,557 - 16,396,172 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl48,158,396 - 8,382,435 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.148,158,395 - 8,382,435 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.248,078,824 - 8,424,733 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18127,293,797 - 127,567,218 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8127,293,834 - 127,567,771 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603912,540,183 - 12,814,478 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473522,862,443 - 23,083,475 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473522,864,373 - 23,083,457 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tg
5391 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3020
Count of miRNA genes:885
Interacting mature miRNAs:1229
Transcripts:ENSMUST00000065916, ENSMUST00000163495, ENSMUST00000166403, ENSMUST00000166906, ENSMUST00000167344, ENSMUST00000167512, ENSMUST00000171045, ENSMUST00000172153
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401902Sicd2_mseizure-induced cell death 2 (mouse)Not determined15347438971197538Mouse
4141952W3q7_mweight 3 weeks QTL 7 (mouse)Not determined348969478601286Mouse
4142252Tailaq4_mtail length adjusted QTL 4 (mouse)Not determined348969478601286Mouse
4142448Tailq6_mtail length QTL 6 (mouse)Not determined348969478601286Mouse
1357559Scfq2_msubcutaneous fat pad weight QTL 2 (mouse)Not determined15348969478601286Mouse
1357659Epfpq4_mepididymal fat percentage QTL 4 (mouse)Not determined15348969478601286Mouse
26884387Skwq8_mskull length QTL 8, 10 week (mouse)15612948168271849Mouse
26884412Bzwq10_mbi-zygomatic width QTL 10, 10 week (mouse)15612948171471849Mouse
26884417Bzwq4_mbi-zygomatic width QTL 4, 5 week (mouse)15612948172471849Mouse
27226786Feml11_mfemur length 11, 5 week (mouse)15612948175871849Mouse
27095932Ulnl11_mulna length 11, 16 week (mouse)15612948176384200Mouse
27226717Tibw4_mtibia width 4, proximal, 10 week (mouse)15612948178684200Mouse
27226734Tibmd5_mtibia midshaft diameter 5, 10 week (mouse)15612948186684201Mouse
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156129481100797881Mouse
27226721Tibw8_mtibia width 8, proximal, 16 week (mouse)15692948175871849Mouse
27226773Tibl16_mtibia length 16, 10 week (mouse)15692948175871849Mouse
27226777Tibl8_mtibia length 8, 5 week (mouse)15692948184584201Mouse
1301433Rapop5_mradiation-induced apoptosis 5 (mouse)Not determined15927302279474762Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402203102896555Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800146102008435Mouse
26884392Humsd8_mhumerus midshaft diameter 8, 16 week (mouse)152930014676084200Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578416103425899Mouse
1300578Cd8ts3_mCD8 T cell subset 3 (mouse)Not determined153400469468004804Mouse
1301324Cdif_mcolor difference (mouse)Not determined153597590669976019Mouse
27226729Tibmd2_mtibia midshaft diameter 2, 5 week (mouse)153800024486684201Mouse
1301580Hrq2_mheart rate quantitative locus 2 (mouse)Not determined153910039573100593Mouse
4142459Lfnq3_mlung function QTL 3 (mouse)Not determined4017702272372580Mouse
26884402Cvht9_mcranial vault height 9, 16 week (mouse)154216339695497881Mouse
1357703Vtbt17_mvertebral trabecular bone trait 17 (mouse)Not determined154455331378553437Mouse
1301568Tria2_mT-cell receptor induced activation 2 (mouse)Not determined154485914178859281Mouse
26884420Cvht6_mcranial vault height 6, 10 week (mouse)154556339669171849Mouse
1357756Alaa4_malopecia areata 4 (mouse)Not determined154638964680389845Mouse
10755515Amzn3_manatomical modifier of Zfp423 3 (mouse)154638964680389845Mouse
1301006Hfib1_mhepatic fibrogenesis 1 (mouse)Not determined154730633481306479Mouse
1301860Gct3_mgranulosa cell tumorigenesis 3 (mouse)Not determined154740959681409691Mouse
26884397Humsd5_mhumerus midshaft diameter 5, 10 week (mouse)154836339698397881Mouse
26884399Humsd1_mhumerus midshaft diameter 1, 5 week (mouse)1548363396101708435Mouse
1301429Pcir3_mperiosteal circumference 3 (mouse)Not determined154846536282465496Mouse
1301779Dpml_mdopamine loss (mouse)Not determined155100469476794493Mouse
4142198Hbtq_mhabituation QTL (mouse)Not determined155116070885160833Mouse
10045637Heal27_mwound healing/regeneration 29 (mouse)Not determined155141836185418511Mouse
10412067Pain2_mpain 2 (mouse)Not determined155164533985645626Mouse
1302080Szs13_mseizure susceptibility 13 (mouse)Not determined155168583285694449Mouse
1301708Cocrb14_mcocaine related behavior 14 (mouse)Not determined155180651585806651Mouse
38501067Tip3_mtuberculosis immunophenotype 3, IFN-g level (mouse)155356339689584203Mouse
13504731Cath5_mcarotid atherosclerosis 5 (mouse)155478912988789129Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556186708103425899Mouse
27095936Ulnl4_mulna length 4, 5 week (mouse)155676339687684201Mouse
1300800Ses3_msalmonella enteritidis susceptibility 3 (mouse)Not determined155711700591117153Mouse
1357407Pfat4_mpredicted fat percentage 4 (mouse)8.6Body fat amountpredicted fat percentage155711700591117153Mouse
12880420V25Dq8_mvitamin D inactive form serum level QTL 8 (mouse)156158420095584200Mouse
1301601Faq9_mfluctuating asymmetry QTL 9 (mouse)Not determined156316390397163995Mouse
1558786Msq1_mMAV-1 susceptibility QTL 1 (mouse)Not determined156338964681086436Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564306334103425899Mouse
4141135Cia35_mcollagen induced arthritis 35 (mouse)Not determined156481182698811946Mouse
1301119Drb7_mdopamine receptor binding 7 (mouse)Not determined156533657899341028Mouse
1301171Brm2_mbrachyury modifier 2 (mouse)Not determined156552537699525499Mouse
1300813Lcho4_mliver cholesterol 4 (mouse)Not determined156654260366722570Mouse

Markers in Region
D15Mit106  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381566,843,674 - 66,843,764UniSTSGRCm38
MGSCv371566,675,236 - 66,675,326UniSTSGRCm37
Celera1568,376,356 - 68,376,446UniSTS
Cytogenetic Map15D3-EUniSTS
cM Map1542.0UniSTS
Whitehead Genetic1535.0UniSTS
D15Mit211  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381566,754,868 - 66,754,992UniSTSGRCm38
MGSCv371566,586,430 - 66,586,554UniSTSGRCm37
Celera1568,287,401 - 68,287,525UniSTS
Cytogenetic Map15D3-EUniSTS
cM Map1530.2UniSTS
Whitehead Genetic1528.4UniSTS
Whitehead_YAC15 UniSTS
Sla  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381566,781,052 - 66,781,980UniSTSGRCm38
MGSCv371566,612,614 - 66,613,542UniSTSGRCm37
Celera1568,313,588 - 68,314,516UniSTS
Cytogenetic Map15D2UniSTS
Cytogenetic Map15D3-EUniSTS
cM Map1537.5UniSTS
cM Map1537.5UniSTS
Tg  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381566,737,519 - 66,739,161UniSTSGRCm38
MGSCv371566,569,081 - 66,570,723UniSTSGRCm37
Celera1568,270,050 - 68,271,692UniSTS
Cytogenetic Map15D3-EUniSTS
cM Map1536.4UniSTS
D11S3038  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381936,584,358 - 36,585,349UniSTSGRCm38
GRCm381566,825,209 - 66,826,403UniSTSGRCm38
MGSCv371566,656,771 - 66,657,965UniSTSGRCm37
MGSCv371936,658,848 - 36,659,839UniSTSGRCm37
Celera1937,358,740 - 37,359,731UniSTS
Celera1568,357,901 - 68,359,095UniSTS
Cytogenetic Map15D2UniSTS
Cytogenetic Map19C2UniSTS
Cytogenetic Map15D3-EUniSTS
cM Map1537.5UniSTS
Sla  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381566,782,639 - 66,782,734UniSTSGRCm38
MGSCv371566,614,201 - 66,614,296UniSTSGRCm37
Celera1568,315,175 - 68,315,270UniSTS
Cytogenetic Map15D3-EUniSTS
Cytogenetic Map15D2UniSTS
cM Map1537.5UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000065916   ⟹   ENSMUSP00000070239
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1566,542,602 - 66,722,570 (+)Ensembl
GRCm38.p6 Ensembl1566,670,753 - 66,850,721 (+)Ensembl
RefSeq Acc Id: ENSMUST00000163495
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1566,577,139 - 66,722,456 (+)Ensembl
GRCm38.p6 Ensembl1566,705,290 - 66,850,607 (+)Ensembl
RefSeq Acc Id: ENSMUST00000166403   ⟹   ENSMUSP00000155392
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1566,670,599 - 66,722,570 (+)Ensembl
GRCm38.p6 Ensembl1566,798,750 - 66,850,721 (+)Ensembl
RefSeq Acc Id: ENSMUST00000167344
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1566,588,380 - 66,601,478 (+)Ensembl
GRCm38.p6 Ensembl1566,716,531 - 66,729,629 (+)Ensembl
RefSeq Acc Id: ENSMUST00000167512
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1566,573,128 - 66,586,984 (+)Ensembl
GRCm38.p6 Ensembl1566,701,279 - 66,715,135 (+)Ensembl
RefSeq Acc Id: ENSMUST00000171045   ⟹   ENSMUSP00000126454
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1566,587,738 - 66,722,570 (+)Ensembl
GRCm38.p6 Ensembl1566,715,889 - 66,850,721 (+)Ensembl
RefSeq Acc Id: ENSMUST00000172153
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1566,608,099 - 66,722,570 (+)Ensembl
GRCm38.p6 Ensembl1566,736,250 - 66,850,721 (+)Ensembl
RefSeq Acc Id: NM_009375   ⟹   NP_033401
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391566,542,619 - 66,722,570 (+)NCBI
GRCm381566,670,770 - 66,850,721 (+)NCBI
MGSCv371566,502,332 - 66,682,283 (+)RGD
Celera1568,203,057 - 68,383,403 (+)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006520745   ⟹   XP_006520808
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391566,542,606 - 66,722,570 (+)NCBI
GRCm381566,670,754 - 66,850,721 (+)NCBI
Sequence:
RefSeq Acc Id: XR_004938813
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391566,550,638 - 66,721,377 (+)NCBI
Sequence:
RefSeq Acc Id: NP_033401   ⟸   NM_009375
- Peptide Label: precursor
- UniProtKB: Q2NKY1 (UniProtKB/Swiss-Prot),   O88590 (UniProtKB/Swiss-Prot),   Q9QWY7 (UniProtKB/Swiss-Prot),   O08710 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006520808   ⟸   XM_006520745
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000070239   ⟸   ENSMUST00000065916
RefSeq Acc Id: ENSMUSP00000155392   ⟸   ENSMUST00000166403
RefSeq Acc Id: ENSMUSP00000126454   ⟸   ENSMUST00000171045
Promoters
RGD ID:8683880
Promoter ID:EPDNEW_M19971
Type:single initiation site
Name:Tg_1
Description:Mus musculus thyroglobulin , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381566,670,752 - 66,670,812EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98733 AgrOrtholog
Ensembl Genes ENSMUSG00000053469 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000065916 ENTREZGENE
  ENSMUST00000065916.14 UniProtKB/Swiss-Prot
  ENSMUST00000166403.2 UniProtKB/TrEMBL
  ENSMUST00000171045.9 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.800.10 UniProtKB/Swiss-Prot
  Tumor Necrosis Factor Receptor, subunit A, domain 2 UniProtKB/Swiss-Prot
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CarbesteraseB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carboxylesterase_B_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thyroglobulin UniProtKB/Swiss-Prot
  Thyroglobulin_1 UniProtKB/Swiss-Prot
  Thyroglobulin_1_sf UniProtKB/Swiss-Prot
  Tyr-kin_ephrin_A/B_rcpt-like UniProtKB/Swiss-Prot
KEGG Report mmu:21819 UniProtKB/Swiss-Prot
MGD MGI:98733 ENTREZGENE
NCBI Gene 21819 ENTREZGENE
PANTHER HLA CLASS II GAMMA CHAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THYROGLOBULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam COesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin_rec_like UniProtKB/Swiss-Prot
  Thyroglobulin_1 UniProtKB/Swiss-Prot
PhenoGen Tg PhenoGen
PIRSF Thyroglobulin UniProtKB/Swiss-Prot
PROSITE CARBOXYLESTERASE_B_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THYROGLOBULIN_1_1 UniProtKB/Swiss-Prot
  THYROGLOBULIN_1_2 UniProtKB/Swiss-Prot
SMART Ephrin_rec_like UniProtKB/Swiss-Prot
  SM00211 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57610 UniProtKB/Swiss-Prot
UniProt A6P7M8_MOUSE UniProtKB/TrEMBL
  F6XYF6_MOUSE UniProtKB/TrEMBL
  O08710 ENTREZGENE
  O88590 ENTREZGENE
  Q2NKY1 ENTREZGENE
  Q9QWY7 ENTREZGENE
  THYG_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary O88590 UniProtKB/Swiss-Prot
  Q2NKY1 UniProtKB/Swiss-Prot
  Q9QWY7 UniProtKB/Swiss-Prot