Slc9a1 (solute carrier family 9 (sodium/hydrogen exchanger), member 1) - Rat Genome Database

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Gene: Slc9a1 (solute carrier family 9 (sodium/hydrogen exchanger), member 1) Mus musculus
Analyze
Symbol: Slc9a1
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 1
RGD ID: 11317
MGI Page MGI
Description: Enables sodium:proton antiporter activity. Acts upstream of or within several processes, including cardiac muscle cell differentiation; response to acidic pH; and sodium ion transport. Located in apical plasma membrane. Part of transporter complex. Is expressed in several structures, including alimentary system; early conceptus; gonad; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 19 and congestive heart failure. Orthologous to human SLC9A1 (solute carrier family 9 member A1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A; ant; Apnh; AW554487; mir-5122; Mir5122; Na(+)/H(+) exchanger 1; Na+/H+ antiporter; Na+/H+, amiloride sensitive; Nhe; Nhe-; NHE-1; Nhe1; slow-wave epilepsy; sodium/hydrogen exchanger 1; solute carrier family 9 member 1; solute carrier family 9, member 1; swe
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394133,097,022 - 133,151,013 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4133,097,017 - 133,151,013 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384133,369,711 - 133,423,702 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4133,369,706 - 133,423,702 (+)Ensemblmm10GRCm38
MGSCv374132,925,687 - 132,979,613 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364132,642,305 - 132,695,773 (+)NCBIMGSCv36mm8
Celera4131,535,491 - 131,589,316 (+)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map466.25NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrobenzenesulfonic acid  (EXP)
2-methylcholine  (ISO)
3-iodobenzyl-5'-N-methylcarboxamidoadenosine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
8-Br-cAMP  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldosterone  (ISO)
all-trans-retinoic acid  (ISO)
amiloride  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbachol  (EXP)
carbon dioxide  (ISO)
CGP 52608  (ISO)
CGS-21680  (ISO)
chlorpyrifos  (EXP)
citronellal  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
DDT  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
digoxin  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
eplerenone  (ISO)
ethanol  (EXP)
ethylisopropylamiloride  (ISO)
fenthion  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
hydrogen peroxide  (ISO)
ketamine  (ISO)
Licochalcone B  (ISO)
lithium atom  (EXP,ISO)
lithium chloride  (ISO)
lithium hydride  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercaptoethanol  (EXP)
methapyrilene  (ISO)
methidathion  (EXP)
nickel atom  (ISO)
okadaic acid  (ISO)
ouabain  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenanthrolines  (EXP)
phenylephrine  (ISO)
phloretin  (ISO)
pirinixic acid  (EXP,ISO)
progesterone  (ISO)
quercetin  (ISO)
reactive nitrogen species  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (ISO)
sodium chloride  (ISO)
tebuconazole  (ISO)
tetrachloromethane  (ISO)
tetrodotoxin  (EXP)
thiram  (ISO)
titanium dioxide  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tungsten  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
zidovudine  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cardiac muscle cell contraction  (IEA,ISO)
cardiac muscle cell differentiation  (IMP)
cell differentiation  (IEA,ISO)
cellular response to acidic pH  (IEA,ISO,ISS)
cellular response to antibiotic  (IEA,ISO)
cellular response to cold  (IEA,ISO)
cellular response to electrical stimulus  (IEA,ISO)
cellular response to epinephrine stimulus  (IEA,ISO)
cellular response to hypoxia  (IEA,ISO)
cellular response to insulin stimulus  (IEA,ISO)
hyaluronan catabolic process  (ISO)
intracellular sodium ion homeostasis  (IEA,ISO)
monoatomic cation transport  (IEA)
monoatomic ion transport  (IEA)
negative regulation of apoptotic process  (IEA,ISO)
positive regulation of action potential  (IEA,ISO)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of calcineurin-NFAT signaling cascade  (IEA,ISO)
positive regulation of cardiac muscle hypertrophy  (IEA,ISO)
positive regulation of cell growth  (IEA,ISO)
positive regulation of intracellular signal transduction  (IEA,ISO)
positive regulation of mitochondrial membrane permeability  (IEA,ISO)
positive regulation of the force of heart contraction  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
potassium ion transmembrane transport  (IBA)
protein complex oligomerization  (ISS)
proton transmembrane transport  (IEA,ISO)
regulation of cardiac muscle contraction by calcium ion signaling  (IEA,ISO)
regulation of intracellular pH  (IBA,IEA,ISO)
regulation of pH  (IDA,IEA,IMP,ISO)
regulation of the force of heart contraction  (IEA,ISO)
regulation of the force of heart contraction by cardiac conduction  (IEA,ISO)
response to acidic pH  (IEA,IMP,ISO)
response to muscle stretch  (IEA,ISO)
sodium ion export across plasma membrane  (ISS)
sodium ion import across plasma membrane  (IBA,IEA,ISO)
sodium ion transport  (IDA,IEA)
stem cell differentiation  (IMP)
transmembrane transport  (IEA)

Cellular Component
apical plasma membrane  (IDA,IEA,ISO)
basolateral plasma membrane  (IEA,ISO,ISS,TAS)
cation-transporting ATPase complex  (IEA,ISO)
cell surface  (IEA,ISO)
cytoplasm  (IEA,ISO,ISS)
intercalated disc  (IEA,ISO)
membrane  (IDA,IEA)
membrane raft  (IEA,ISO)
mitochondrion  (IEA)
nucleoplasm  (IEA,ISO)
perinuclear region of cytoplasm  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO,ISS)
sarcolemma  (IEA,ISO)
T-tubule  (IEA,ISO)
transporter complex  (IDA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Chronic NHE-1 blockade induces an antiapoptotic effect in the hypertrophied heart. Garciarena CD, etal., J Appl Physiol. 2009 Apr;106(4):1325-31. Epub 2009 Jan 29.
2. Contractility of ventricular myocytes is well preserved despite altered mechanisms of Ca2+ transport and a changing pattern of mRNA in aged type 2 Zucker diabetic fatty rat heart. Howarth FC, etal., Mol Cell Biochem. 2012 Feb;361(1-2):267-80. Epub 2011 Oct 19.
3. Identification of a potent Sodium Hydrogen Exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat. Huber JD, etal., J Med Chem. 2012 Jul 17.
4. Altered expression of Na(+)/H(+) exchanger isoforms 1 and 3 in clipped and unclipped kidneys of a 2-kidney-1-clip Goldblatt model of hypertension. Khan I, etal., Nephron 2002 Oct;92(2):346-55.
5. Neurovascular protection in voltage-gated proton channel Hv1 knock-out rats after ischemic stroke: interaction with Na+ /H+ exchanger-1 antagonism. Li W, etal., Physiol Rep. 2019 Aug;7(13):e14142. doi: 10.14814/phy2.14142.
6. Thyroid hormone receptor alpha 1 regulates expression of the Na+/H+ exchanger (NHE1). Li X, etal., J Biol Chem 2002 Aug 9;277(32):28656-62.
7. [Adenosine alleviates hypoxia-induced rat right ventricular hypertrophy through the NHE-1/CaN signal pathway]. Lin M, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2012 May;32(5):734-7.
8. [Cariporide pretreatment attenuated warm ischemia/reperfusion injury in an isolated rat lung: a study on antioxidative mechanism]. Lin X, etal., Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2010 Feb;27(1):132-7.
9. Na+/H+-exchanger-1 inhibition counteracts diabetic cataract formation and retinal oxidative-nitrative stress and apoptosis. Lupachyk S, etal., Int J Mol Med. 2012 Jun;29(6):989-98. doi: 10.3892/ijmm.2012.933. Epub 2012 Mar 7.
10. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
11. MGDs mouse GO annotations MGD data from the GO Consortium
12. MGD IEA MGD IEA
13. Activation of Na+/H+ exchanger 1 is sufficient to generate Ca2+ signals that induce cardiac hypertrophy and heart failure. Nakamura TY, etal., Circ Res. 2008 Oct 10;103(8):891-9. Epub 2008 Sep 5.
14. The effect of Na(+)/H(+) exchanger-1 inhibition by sabiporide on blood-brain barrier dysfunction after ischemia/hypoxia in vivo and in vitro. Park SL, etal., Brain Res. 2010 Dec 17;1366:189-96. Epub 2010 Sep 29.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. Mouse MP Annotation Import Pipeline RGD automated import pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Na+/H+ exchange inhibition with cariporide prevents alterations of coronary endothelial function in streptozotocin-induced diabetes. Vial G, etal., Mol Cell Biochem. 2008 Mar;310(1-2):93-102. Epub 2007 Dec 5.
21. A physiogenomic approach to study the regulation of blood pressure. Westhoff TH, etal., Physiol Genomics. 2005 Sep 21;23(1):46-53. Epub 2005 Jun 7.
22. The rise of [Na(+)] (i) during ischemia and reperfusion in the rat heart-underlying mechanisms. Williams IA, etal., Pflugers Arch. 2007 Mar 14;.
23. Low-volume resuscitation from traumatic hemorrhagic shock with Na+/H+ exchanger inhibitor. Wu D, etal., Crit Care Med. 2009 Jun;37(6):1994-9.
Additional References at PubMed
PMID:1979310   PMID:7631785   PMID:7829080   PMID:7836405   PMID:7907077   PMID:8016086   PMID:8094369   PMID:8199403   PMID:8824815   PMID:8979265   PMID:9016300   PMID:9278382  
PMID:9335342   PMID:9590530   PMID:9613608   PMID:10199808   PMID:10349636   PMID:10395577   PMID:10446746   PMID:10487778   PMID:10506152   PMID:10515158   PMID:10591541   PMID:10663560  
PMID:10666041   PMID:10666043   PMID:10673550   PMID:10841524   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11163215   PMID:11217851   PMID:11254496   PMID:11358967   PMID:11443048  
PMID:11700294   PMID:11931388   PMID:11988776   PMID:12063300   PMID:12195293   PMID:12221084   PMID:12453872   PMID:12466851   PMID:12477932   PMID:12486114   PMID:12493726   PMID:12522174  
PMID:12619893   PMID:12842825   PMID:12904583   PMID:12970112   PMID:14610273   PMID:14681479   PMID:14962844   PMID:15013953   PMID:15090545   PMID:15257760   PMID:15292047   PMID:15306696  
PMID:15782199   PMID:15843440   PMID:15901600   PMID:16141072   PMID:16141073   PMID:16200063   PMID:16216978   PMID:16297477   PMID:16339021   PMID:16602821   PMID:16690903   PMID:16717153  
PMID:16766575   PMID:17177603   PMID:17525272   PMID:17535745   PMID:17571084   PMID:17581135   PMID:17599909   PMID:17664275   PMID:17890222   PMID:17977915   PMID:18310478   PMID:18363831  
PMID:18662334   PMID:18799693   PMID:19011045   PMID:19036852   PMID:19261908   PMID:19341767   PMID:19349585   PMID:19369449   PMID:19605632   PMID:20460605   PMID:20557427   PMID:20855896  
PMID:21037258   PMID:21068326   PMID:21196287   PMID:21267068   PMID:21359875   PMID:21403133   PMID:21574244   PMID:21677750   PMID:21705333   PMID:21873635   PMID:21900251   PMID:21947380  
PMID:22020933   PMID:22212557   PMID:22351634   PMID:22366186   PMID:22490613   PMID:22508060   PMID:22508061   PMID:22613966   PMID:22627677   PMID:22683701   PMID:22688515   PMID:22740348  
PMID:22922957   PMID:23264740   PMID:23676500   PMID:23677982   PMID:23800993   PMID:23904602   PMID:23991215   PMID:24035762   PMID:24038847   PMID:24080184   PMID:24163350   PMID:24173371  
PMID:24531551   PMID:24566089   PMID:24566932   PMID:24976401   PMID:25758355   PMID:26138884   PMID:27009277   PMID:27035646   PMID:27509531   PMID:27629415   PMID:28031107   PMID:28319329  
PMID:28339658   PMID:28483634   PMID:28704808   PMID:28925083   PMID:29473817   PMID:29694915   PMID:30043461   PMID:30191998   PMID:30262908   PMID:30541023   PMID:31484936   PMID:31518570  
PMID:31996021   PMID:32325033   PMID:32554809   PMID:33201382   PMID:33354894   PMID:33391535   PMID:34108458   PMID:35440572   PMID:36130017   PMID:36876794   PMID:37471646   PMID:37686096  
PMID:38187761   PMID:38344766   PMID:38355793   PMID:38397773   PMID:38509618   PMID:39118129   PMID:39615283  


Genomics

Comparative Map Data
Slc9a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394133,097,022 - 133,151,013 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4133,097,017 - 133,151,013 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384133,369,711 - 133,423,702 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4133,369,706 - 133,423,702 (+)Ensemblmm10GRCm38
MGSCv374132,925,687 - 132,979,613 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364132,642,305 - 132,695,773 (+)NCBIMGSCv36mm8
Celera4131,535,491 - 131,589,316 (+)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map466.25NCBI
SLC9A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38127,098,809 - 27,155,125 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl127,098,809 - 27,166,981 (-)Ensemblhg38GRCh38
GRCh37127,425,300 - 27,481,616 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,297,894 - 27,353,990 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34127,109,448 - 27,165,543NCBI
Celera125,822,106 - 25,878,256 (-)NCBICelera
Cytogenetic Map1p36.11NCBI
HuRef125,679,019 - 25,736,027 (-)NCBIHuRef
CHM1_1127,539,712 - 27,596,211 (-)NCBICHM1_1
T2T-CHM13v2.0126,938,788 - 26,996,283 (-)NCBIT2T-CHM13v2.0
Slc9a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85150,859,412 - 150,913,525 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5150,860,228 - 150,913,517 (+)EnsemblGRCr8
mRatBN7.25145,576,341 - 145,629,630 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5145,576,334 - 145,629,624 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5148,278,173 - 148,331,396 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05150,047,784 - 150,101,012 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05150,034,322 - 150,087,546 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05151,573,122 - 151,626,360 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5151,573,092 - 151,627,316 (+)Ensemblrn6Rnor6.0
Rnor_5.05155,237,482 - 155,290,410 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45151,680,696 - 151,748,460 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5143,998,303 - 144,051,177 (+)NCBICelera
RGSC_v3.15151,690,734 - 151,758,499 (-)NCBI
RH 3.4 Map5977.9RGD
Cytogenetic Map5q36NCBI
Slc9a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554526,409,833 - 6,467,841 (-)Ensembl
ChiLan1.0NW_0049554526,409,833 - 6,467,841 (-)NCBIChiLan1.0ChiLan1.0
SLC9A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21199,713,762 - 199,772,871 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11198,817,765 - 198,876,989 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0126,359,818 - 26,418,910 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1127,414,937 - 27,475,089 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,414,937 - 27,475,089 (-)EnsemblpanPan2panpan1.1
SLC9A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,054,742 - 73,103,364 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,054,742 - 73,103,364 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha269,631,268 - 69,679,864 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0273,616,211 - 73,664,827 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl273,616,211 - 73,664,827 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1270,441,943 - 70,490,513 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0271,447,299 - 71,495,908 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0272,450,107 - 72,498,704 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc9a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505845,635,479 - 45,692,666 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647411,459,929 - 11,517,478 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647411,460,266 - 11,517,420 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC9A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl684,372,649 - 84,426,997 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1684,373,921 - 84,426,447 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2677,944,221 - 77,996,927 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC9A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120105,613,289 - 105,670,868 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20105,613,338 - 105,674,208 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603310,772,194 - 10,834,851 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc9a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476411,039,051 - 11,095,885 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476411,041,118 - 11,095,892 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

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Variants in Slc9a1
2475 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1441
Count of miRNA genes:628
Interacting mature miRNAs:786
Transcripts:ENSMUST00000030669, ENSMUST00000132864, ENSMUST00000140681, ENSMUST00000141658, ENSMUST00000156079
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
25394567Skmw55_mskeletal muscle weight 55, gastroc (mouse)4131437804133710576Mouse
10047132Albq19_malbuminuria QTL 19 (mouse)Not determined4112824389146824389Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124264957150676858Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined88982069140468203Mouse
12910797Pwgrq4_mpre-weaning growth rate QTL 4 (mouse)4105835310141433838Mouse
14696808Rbcn1_mrod bipolar cell number 1 (mouse)4131947311134047311Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
25394568Skmw56_mskeletal muscle weight 56, EDL (mouse)4129859344133710576Mouse
12904009Cfq9_mconditioned fear QTL 9 (mouse)4130036287133772722Mouse
12910794Pwbwq8_mpost-weaning body weight QTL 8 (mouse)4105835310141433838Mouse
1300743Skull6_mskull morphology 6 (mouse)Not determined4111009051145009280Mouse
1301382Arvm2_mautoimmune renal vasculitis 2 (mouse)Not determined4107791564141791756Mouse
1302149Tlsr2_mthymic lymphoma suppressor region 2 (mouse)Not determined4124264957142230960Mouse
12910813Pwbwq4_mpre-weaning body weight QTL 4 (mouse)4105835310141433838Mouse
1300874Gasa2_mgastritis type A susceptibility locus 2 (mouse)Not determined4133010494156860686Mouse
4141093W3q17_mweight 3 weeks QTL 17 (mouse)Not determined88982069140468203Mouse
27226757Femd1_mfemur midshaft diameter 1, 5 week (mouse)4123993793144326570Mouse
12910808Pwbwq9_mpost-weaning body weight QTL 9 (mouse)4105835310141433838Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125230872156860686Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116154678150154782Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
1300663Start2_mstartle response 2 (mouse)Not determined4107264957141265153Mouse
1300917Gasa1_mgastritis type A susceptibility locus 1 (mouse)Not determined4124055093142438020Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120617848154617995Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117401141151401275Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125230872156860686Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4127784226156860686Mouse
1301793Tlsr3_mthymic lymphoma suppressor region 3 (mouse)Not determined4129465811136864536Mouse
10412072Ssen1_msuseptibility to Sendai virus 1 (mouse)Not determined4109658132133154782Mouse
4141065Shali2_msurvival time to hyperoxic acute lung injury 2 (mouse)Not determined124055093141572792Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120617848154617995Mouse
13208562Wght7_mweight 7 (mouse)490888237148084457Mouse
1300781Lith8_mlithogenic gene 8 (mouse)Not determined4107264957141265153Mouse
39128212Lwq21_mliver weight QTL 21 (mouse)488982069140468203Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120674005154674151Mouse
1301584Lrdg2_mlight induced retinal degeneration 2 (mouse)Not determined4129465811151654550Mouse
1301847Fecq2_mfecundity QTL 2 (mouse)Not determined4100071971134072206Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4119864433153864536Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4127784226156860686Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121342649155342753Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124621281156860686Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120674005154674151Mouse
4141549W10q10_mweight 10 weeks QTL 10 (mouse)Not determined88982069140468203Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121342649155342753Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125230872156860686Mouse
1300809Ccrs2_mcorpus callosum hemisphere surface size 2 (mouse)Not determined4107264957141265153Mouse
4141154Nba1_mNew Zealand Black autoimmunity 1 (mouse)Not determined131650724140879275Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4119864433153864536Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121342649155342753Mouse
1301106Skts7_mskin tumor susceptibility 7 (mouse)Not determined4100071971134072206Mouse
10755520Rbc1_mred blood cell count 1 (mouse)4108477692142477692Mouse
10755521Hct1_mhematocrit 1 (mouse)4108477692142477692Mouse
10755522Hgb1_mhemoglobin 1 (mouse)4108477692142477692Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124621281156860686Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124553483156860686Mouse
15039382Ltgq7_mliver triglyceride QTL 7 (mouse)4105705794139705794Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125289325156860686Mouse
15039377Bw45_mbody weight QTL 45 (mouse)4105705794139705794Mouse
1300839Dyscalc2_mdystrophic cardiac calcinosis 2 (mouse)Not determined4111009051145009280Mouse
12880433Fgf23lq1_mFGF23 serum level QTL 1 (mouse)4101157197135157197Mouse
4141001Tgq17_mtriglyceride QTL 17 (mouse)Not determined112523489146523489Mouse
15039378Adip30_madiposity 30 (mouse)4105705794139705794Mouse
1357800Tgq3_mtriglyceride QTL 3 (mouse)Not determined4107055093141055180Mouse
15039385Mvlq3_mmacrovesicular liver lesion QTL 3 (mouse)4112182386146182386Mouse

Markers in Region
AW554487  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384133,423,281 - 133,423,413UniSTSGRCm38
MGSCv374132,979,196 - 132,979,328UniSTSGRCm37
Celera4131,588,899 - 131,589,031UniSTS
Cytogenetic Map4D3-EUniSTS
Whitehead/MRC_RH41758.21UniSTS
U51112  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384133,422,479 - 133,422,653UniSTSGRCm38
MGSCv374132,978,394 - 132,978,568UniSTSGRCm37
Celera4131,588,120 - 131,588,294UniSTS
Cytogenetic Map4D3-EUniSTS
Whitehead_YAC4 UniSTS
Slc9a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4D3-EUniSTS
cM Map464.6UniSTS
Slc9a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4D3-EUniSTS
cM Map464.6UniSTS
Slc9a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4D3-EUniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001358455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_016981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006538686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017320089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK150135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL671882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC052708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ771297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU056477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO041694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JF446422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LM611526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U51112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000030669   ⟹   ENSMUSP00000030669
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4133,097,017 - 133,151,013 (+)Ensembl
GRCm38.p6 Ensembl4133,369,706 - 133,423,702 (+)Ensembl
Ensembl Acc Id: ENSMUST00000132864
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4133,146,792 - 133,147,476 (+)Ensembl
GRCm38.p6 Ensembl4133,419,481 - 133,420,165 (+)Ensembl
Ensembl Acc Id: ENSMUST00000140681
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4133,097,955 - 133,139,447 (+)Ensembl
GRCm38.p6 Ensembl4133,370,644 - 133,412,136 (+)Ensembl
Ensembl Acc Id: ENSMUST00000141658
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4133,147,283 - 133,149,631 (+)Ensembl
GRCm38.p6 Ensembl4133,419,972 - 133,422,320 (+)Ensembl
Ensembl Acc Id: ENSMUST00000156079
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4133,143,617 - 133,147,866 (+)Ensembl
GRCm38.p6 Ensembl4133,416,306 - 133,420,555 (+)Ensembl
RefSeq Acc Id: NM_001358455   ⟹   NP_001345384
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394133,097,046 - 133,151,013 (+)NCBI
GRCm384133,369,735 - 133,423,702 (+)NCBI
Sequence:
RefSeq Acc Id: NM_016981   ⟹   NP_058677
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394133,097,046 - 133,151,013 (+)NCBI
GRCm384133,369,735 - 133,423,702 (+)NCBI
MGSCv374132,925,687 - 132,979,613 (+)RGD
Celera4131,535,491 - 131,589,316 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006538686   ⟹   XP_006538749
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394133,133,703 - 133,151,013 (+)NCBI
GRCm384133,406,288 - 133,423,702 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017320089   ⟹   XP_017175578
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394133,097,022 - 133,151,013 (+)NCBI
GRCm384133,369,711 - 133,423,702 (+)NCBI
Sequence:
RefSeq Acc Id: NP_058677   ⟸   NM_016981
- Peptide Label: isoform 1
- UniProtKB: Q61165 (UniProtKB/Swiss-Prot),   Q3UDC9 (UniProtKB/TrEMBL),   Q3U3A6 (UniProtKB/TrEMBL),   Q80X31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006538749   ⟸   XM_006538686
- Peptide Label: isoform X1
- UniProtKB: Q80X31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017175578   ⟸   XM_017320089
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001345384   ⟸   NM_001358455
- Peptide Label: isoform 2
Ensembl Acc Id: ENSMUSP00000030669   ⟸   ENSMUST00000030669
Protein Domains
Cation/H+ exchanger transmembrane   Sodium/hydrogen exchanger regulatory region

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61165-F1-model_v2 AlphaFold Q61165 1-820 view protein structure

Promoters
RGD ID:6836414
Promoter ID:MM_KWN:40010
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000084240,   OTTMUST00000026125,   OTTMUST00000026126
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364132,925,706 - 132,926,592 (+)MPROMDB
RGD ID:6849166
Promoter ID:MM_XEF:5164
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:NM_001088084,   NM_001124695
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364132,967,826 - 132,968,326 (+)MPROMDB
RGD ID:6836415
Promoter ID:MM_KWN:40011
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung
Transcripts:OTTMUST00000026127
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364132,971,576 - 132,972,177 (+)MPROMDB
RGD ID:6836417
Promoter ID:MM_KWN:40012
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   Brain,   Kidney,   Lung,   Spleen
Transcripts:OTTMUST00000026128,   OTTMUST00000026129
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364132,974,476 - 132,975,927 (+)MPROMDB
RGD ID:6884948
Promoter ID:EPDNEW_M5925
Type:initiation region
Name:Slc9a1_1
Description:Mus musculus solute carrier family 9 (sodium/hydrogen exchanger),member 1 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384133,369,772 - 133,369,832EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:102462 AgrOrtholog
Ensembl Genes ENSMUSG00000028854 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000030669 ENTREZGENE
  ENSMUST00000030669.8 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.140.1330 UniProtKB/Swiss-Prot
  6.10.250.1040 UniProtKB/Swiss-Prot
  6.10.250.2020 UniProtKB/Swiss-Prot
InterPro Cation/H_exchanger UniProtKB/Swiss-Prot
  Cation/H_exchanger_CPA1 UniProtKB/Swiss-Prot
  Na/H_exchanger_1 UniProtKB/Swiss-Prot
  NaH_exchanger UniProtKB/Swiss-Prot
  NHE_CaM-bd UniProtKB/Swiss-Prot
KEGG Report mmu:20544 UniProtKB/Swiss-Prot
MGD MGI:102462 ENTREZGENE
NCBI Gene 20544 ENTREZGENE
PANTHER PTHR10110 UniProtKB/Swiss-Prot
  PTHR10110:SF59 UniProtKB/Swiss-Prot
Pfam Na_H_Exchanger UniProtKB/Swiss-Prot
  NEXCaM_BD UniProtKB/Swiss-Prot
PhenoGen Slc9a1 PhenoGen
PRINTS NAHEXCHNGR UniProtKB/Swiss-Prot
  NAHEXCHNGR1 UniProtKB/Swiss-Prot
UniProt Q3TN68_MOUSE UniProtKB/TrEMBL
  Q3U3A6 ENTREZGENE, UniProtKB/TrEMBL
  Q3UDC9 ENTREZGENE, UniProtKB/TrEMBL
  Q61165 ENTREZGENE
  Q7TSV2_MOUSE UniProtKB/TrEMBL
  Q80X31 ENTREZGENE, UniProtKB/TrEMBL
  Q99KF4_MOUSE UniProtKB/TrEMBL
  SL9A1_MOUSE UniProtKB/Swiss-Prot