Ighg1 (immunoglobulin heavy constant gamma 1 (G1m marker)) - Rat Genome Database

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Gene: Ighg1 (immunoglobulin heavy constant gamma 1 (G1m marker)) Mus musculus
Analyze
Symbol: Ighg1
Name: immunoglobulin heavy constant gamma 1 (G1m marker)
RGD ID: 11302549
MGI Page MGI
Description: Enables antigen binding activity and immunoglobulin receptor binding activity. Involved in B cell differentiation. Acts upstream of or within several processes, including antibody-dependent cellular cytotoxicity; phagocytosis; and positive regulation of immune response. Located in external side of plasma membrane and extracellular space. Part of immunoglobulin complex, circulating. Is active in cytoplasm. Orthologous to several human genes including IGHG1 (immunoglobulin heavy constant gamma 1 (G1m marker)); IGHG2 (immunoglobulin heavy constant gamma 2 (G2m marker)); and IGHG3 (immunoglobulin heavy constant gamma 3 (G3m marker)).
Type: gene (Ensembl: IG_C_gene)
RefSeq Status: VALIDATED
Previously known as: IgG; IgG1; Igh-; Igh-4; VH7183
RGD Orthologs
Human
Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912113,290,161 - 113,294,143 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12113,288,860 - 113,294,143 (-)EnsemblGRCm39 Ensembl
GRCm3812113,326,541 - 113,330,523 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12113,325,240 - 113,330,523 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712114,564,755 - 114,568,734 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera12114,512,547 - 114,780,893 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1262.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell differentiation  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal class switch recombination  (IAGP)
abnormal germinal center B cell physiology  (IAGP)
abnormal immunoglobulin level  (IAGP)
abnormal mature B cell morphology  (IAGP)
abnormal memory B cell morphology  (IAGP)
abnormal plasma cell differentiation  (IAGP)
abnormal somatic hypermutation frequency  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal splenic cell ratio  (IAGP)
absent memory B cells  (IAGP)
absent plasma cells  (IAGP)
absent spleen germinal center  (IAGP)
decreased B cell number  (IAGP)
decreased B cell proliferation  (IAGP)
decreased body temperature  (IAGP)
decreased follicular B cell number  (IAGP)
decreased germinal center B cell number  (IAGP)
decreased IgA level  (IAGP)
decreased IgG level  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG2a level  (IAGP)
decreased IgG2b level  (IAGP)
decreased IgG2c level  (IAGP)
decreased IgG3 level  (IAGP)
decreased plasma cell number  (IAGP)
decreased spleen germinal center number  (IAGP)
decreased spleen germinal center size  (IAGP)
decreased survivor rate  (IAGP)
decreased susceptibility to systemic lupus erythematosus  (IAGP)
decreased tumor-free survival time  (IAGP)
enhanced humoral immune response  (IAGP)
enlarged liver  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased anti-nuclear antigen antibody level  (IAGP)
increased autoantibody level  (IAGP)
increased B cell apoptosis  (IAGP)
increased B cell derived lymphoma incidence  (IAGP)
increased B cell number  (IAGP)
increased follicular lymphoma incidence  (IAGP)
increased germinal center B cell number  (IAGP)
increased histiocytic sarcoma incidence  (IAGP)
increased IgE level  (IAGP)
increased IgG1 level  (IAGP)
increased IgG2a level  (IAGP)
increased IgG2b level  (IAGP)
increased IgM level  (IAGP)
increased macrophage cell number  (IAGP)
increased marginal zone B cell number  (IAGP)
increased plasma cell number  (IAGP)
increased sarcoma incidence  (IAGP)
increased spleen germinal center number  (IAGP)
increased spleen germinal center size  (IAGP)
increased spleen weight  (IAGP)
increased susceptibility to type I hypersensitivity reaction  (IAGP)
increased susceptibility to xenobiotic induced morbidity/mortality  (IAGP)
increased T follicular helper cell number  (IAGP)
increased tumor incidence  (IAGP)
premature death  (IAGP)
References
Additional References at PubMed
PMID:98524   PMID:113776   PMID:115593   PMID:1672339   PMID:1713710   PMID:3031474   PMID:4098598   PMID:4166666   PMID:5073237   PMID:6249338   PMID:6264445   PMID:6283537  
PMID:6306571   PMID:6767246   PMID:6769120   PMID:6769752   PMID:6774258   PMID:6781756   PMID:6798155   PMID:6799207   PMID:6801765   PMID:6804095   PMID:6804950   PMID:7439686  
PMID:7704573   PMID:7892607   PMID:8041705   PMID:8099342   PMID:8438159   PMID:8452816   PMID:8552190   PMID:8566034   PMID:8683112   PMID:8769481   PMID:9103199   PMID:9126488  
PMID:9707605   PMID:9743367   PMID:9834074   PMID:9834201   PMID:10349636   PMID:10395649   PMID:10720538   PMID:11042159   PMID:11057672   PMID:11076861   PMID:11217851   PMID:11812141  
PMID:11911823   PMID:12051834   PMID:12466851   PMID:12477932   PMID:14514727   PMID:14988498   PMID:15692051   PMID:15699144   PMID:16141072   PMID:16141073   PMID:16275384   PMID:16492738  
PMID:16651521   PMID:16767092   PMID:17124007   PMID:17658279   PMID:17675251   PMID:18390753   PMID:18467709   PMID:18542049   PMID:18606706   PMID:18762567   PMID:18835195   PMID:19050247  
PMID:19273623   PMID:19592272   PMID:19703988   PMID:20018855   PMID:20031218   PMID:21037092   PMID:21156282   PMID:21339646   PMID:21505187   PMID:21873635   PMID:22199357   PMID:22249450  
PMID:22431510   PMID:22880085   PMID:22897848   PMID:22922409   PMID:23001146   PMID:23027924   PMID:23423996   PMID:23680150   PMID:23825691   PMID:23850379   PMID:24200695   PMID:24457600  
PMID:24548411   PMID:24563255   PMID:24589747   PMID:25180063   PMID:25348086   PMID:25363774   PMID:25404305   PMID:25505290   PMID:25624445   PMID:25740947   PMID:25801429   PMID:25867470  
PMID:25921526   PMID:26147686   PMID:26201558   PMID:26366712   PMID:26370502   PMID:26620759   PMID:26620760   PMID:26627255   PMID:26683050   PMID:26740101   PMID:27167731   PMID:27218486  
PMID:27428827   PMID:27457619   PMID:27457956   PMID:27480124   PMID:27502364   PMID:27566940   PMID:27769169   PMID:27856754   PMID:27935477   PMID:28069569   PMID:28378742   PMID:28923960  
PMID:29026085   PMID:29118245   PMID:29187734   PMID:29459677   PMID:29531165   PMID:29562201   PMID:29996101   PMID:30013024   PMID:30082494   PMID:30205047   PMID:30274972   PMID:30287618  
PMID:30359469   PMID:30538335   PMID:30604754   PMID:30705065   PMID:30894677   PMID:30975638   PMID:31042473   PMID:31204070   PMID:31375460   PMID:31519498   PMID:31767615   PMID:32006024  
PMID:32229726   PMID:32325033   PMID:32522871   PMID:32591397   PMID:32601467   PMID:32619424   PMID:32640012   PMID:32889526   PMID:33025844   PMID:33163250   PMID:33193409   PMID:33207194  
PMID:33343574   PMID:33432228   PMID:33532715   PMID:34031614   PMID:34050029   PMID:34301867   PMID:34539636   PMID:34555336   PMID:34586363   PMID:34621263   PMID:35044826   PMID:35133976  
PMID:35263577   PMID:35513371   PMID:35815807   PMID:36631557   PMID:36656933   PMID:36763580   PMID:36779803   PMID:36853944   PMID:37033932   PMID:37198323   PMID:37200190   PMID:37310381  
PMID:37730678   PMID:38060451   PMID:38268239   PMID:38438375   PMID:38458187   PMID:38529289   PMID:38570506   PMID:38579014  


Genomics

Comparative Map Data
Ighg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912113,290,161 - 113,294,143 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12113,288,860 - 113,294,143 (-)EnsemblGRCm39 Ensembl
GRCm3812113,326,541 - 113,330,523 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12113,325,240 - 113,330,523 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712114,564,755 - 114,568,734 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera12114,512,547 - 114,780,893 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1262.1NCBI
IGHG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814105,741,473 - 105,743,070 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14105,736,343 - 105,743,071 (-)EnsemblGRCh38hg38GRCh38
GRCh3714106,207,810 - 106,209,407 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614105,278,749 - 105,280,452 (-)NCBINCBI36Build 36hg18NCBI36
Celera1486,146,753 - 86,148,456 (-)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1486,340,115 - 86,341,712 (-)NCBIHuRef
CHM1_114106,106,771 - 106,107,520 (-)NCBICHM1_1
T2T-CHM13v2.014100,012,671 - 100,014,268 (-)NCBIT2T-CHM13v2.0
Ighg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2 Ensembl6132,389,370 - 132,393,397 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.06139,140,572 - 139,784,388 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6139,140,679 - 139,142,218 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06147,106,967 - 147,241,786 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.06148,128,786 - 148,134,027 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46138,310,041 - 138,311,688 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera6129,920,648 - 129,922,321 (-)NCBICelera
Cytogenetic Map6q32NCBI

Variants

.
Variants in Ighg1
2 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:185
Count of miRNA genes:171
Interacting mature miRNAs:175
Transcripts:ENSMUST00000103420
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
39128213Lwq23_mliver weight QTL 10 (mouse)1280956708113383533Mouse
1300883Ath21_matherosclerosis 21 (mouse)Not determined1285961579119961683Mouse
12910532Nrq10a_mnoise-induced hearing loss resistant QTL 10a (mouse)1292750025120092757Mouse
12910533Nrq10_mnoise-induced hearing loss resistant QTL 10 (mouse)1292750025120092757Mouse
1357463Vtbt14_mvertebral trabecular bone trait 14 (mouse)Not determined1292936097120092757Mouse
1301269Sluc12_msusceptibility to lung cancer 12 (mouse)Not determined1296860337120092757Mouse
4142007Chlq17_mcirculating hormone level QTL 17 (mouse)Not determined1288052874120092757Mouse
4141297Plyid_mPolymeric IgA dominance (mouse)Not determined109183385115885122Mouse
1300545Lifespan3_mlife span 3 (mouse)Not determined1288052874120092757Mouse
15092085Igly2_mIgG glycosylation 2, GP14 (mouse)12111737297119992757Mouse
4141610Tailaq1_mtail length adjusted QTL 1 (mouse)Not determined80956708113383533Mouse
1301836Heal5_mwound healing/regeneration 5 (mouse)Not determined1289939031120092757Mouse
13524846Ppiq11_mprepulse inhibition QTL 11 (mouse)1282666396116666396Mouse
10412156Nociq3_mnociceptive sensitivity inflammatory QTL 3 (mouse)Not determined1286396075114831653Mouse
1301879Insq10_minsulin QTL 10 (mouse)Not determined1283532075117532224Mouse
10402491Dipa4_mdrug induced psychomotor activation 4 (mouse)Not determined1291222515120092757Mouse
1301492Dbsty3_mdiabesity 3 (mouse)Not determined1283532075117532224Mouse
4141335W6q10_mweight 6 weeks QTL 10 (mouse)Not determined80956708113383533Mouse
5491194Mobq3_mmultigenic obesity QTL 3 (mouse)Not determined1289664071120092757Mouse
1302138Im6_mimmunoregulatory 6 (mouse)Not determined1296860337120092757Mouse
1301308Prdt4_mprion disease incubation time 4 (mouse)Not determined1288308354120092757Mouse
1301922Bbaa6_mB.burgdorferi-associated arthritis 6 (mouse)Not determined1290308268120092757Mouse
1302177Dps2_mdelta power in slow-wave sleep 2 (mouse)Not determined1294146064120092757Mouse
10412075Nils1_mneointima lesion size 1 (mouse)Not determined12102024665120092757Mouse
27226793Feml10_mfemur length 10, 5 week (mouse)1268346774113363620Mouse
1558957Igan4_mIgA nephropathy 4 (mouse)Not determined12109750025119024949Mouse
4142401Egq10_mearly growth QTL 10 (mouse)Not determined80956708113383533Mouse
1300973Abmm_mantibody mediated myocarditis (mouse)Not determined1293264461120092757Mouse
13524849Ppiq11a_mprepulse inhibition QTL 11a (mouse)1280989143114989143Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000103420   ⟹   ENSMUSP00000100216
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12113,292,494 - 113,294,143 (-)Ensembl
GRCm38.p6 Ensembl12113,328,874 - 113,330,523 (-)Ensembl
Ensembl Acc Id: ENSMUST00000194304   ⟹   ENSMUSP00000141658
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12113,288,860 - 113,294,143 (-)Ensembl
GRCm38.p6 Ensembl12113,325,240 - 113,330,523 (-)Ensembl
Protein Sequences
GenBank Protein BAA11357 (Get FASTA)   NCBI Sequence Viewer  
  BAA11358 (Get FASTA)   NCBI Sequence Viewer  
  CAA24153 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000100216.2
  ENSMUSP00000141658.2
GenBank Protein P01868 (Get FASTA)   NCBI Sequence Viewer  
  P01869 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSMUSP00000141658   ⟸   ENSMUST00000194304
Ensembl Acc Id: ENSMUSP00000100216   ⟸   ENSMUST00000103420
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01869-F1-model_v2 AlphaFold P01869 1-393 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96446 AgrOrtholog
Ensembl Genes ENSMUSG00000076614 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000103420.3 UniProtKB/TrEMBL
  ENSMUST00000194304.6 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_C1-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Immune_Resp_Modulators UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96446 ENTREZGENE
NCBI Gene Ighg1 ENTREZGENE
PANTHER IMMUNOGLOBULIN HEAVY CONSTANT GAMMA 1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAPASIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam C1-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ighg1 PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGc1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A075B5P4_MOUSE UniProtKB/TrEMBL
  A0A0A6YWR2_MOUSE UniProtKB/TrEMBL
  A0A4U9FFL2_MOUSE UniProtKB/TrEMBL
  IGH1M_MOUSE UniProtKB/Swiss-Prot
  IGHG1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  P01869 ENTREZGENE