Ccl2 (C-C motif chemokine ligand 2) - Rat Genome Database

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Gene: Ccl2 (C-C motif chemokine ligand 2) Mus musculus
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Symbol: Ccl2
Name: C-C motif chemokine ligand 2
RGD ID: 11275
MGI Page MGI
Description: Enables CCR2 chemokine receptor binding activity; chemoattractant activity; and cytokine activity. Involved in several processes, including cellular response to cytokine stimulus; positive regulation of leukocyte chemotaxis; and regulation of gene expression. Acts upstream of or within energy homeostasis; response to bacterium; and response to wounding. Located in extracellular space. Is expressed in several structures, including heart; intestine; mandible; nervous system; and retina. Used to study age related macular degeneration. Human ortholog(s) of this gene implicated in several diseases, including IgA vasculitis; aggressive periodontitis; autoimmune disease (multiple); gastrointestinal system cancer (multiple); and lung disease (multiple). Orthologous to human CCL2 (C-C motif chemokine ligand 2).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AI323594; C-C motif chemokine 2; chemokine (C-C motif) ligand 2; HC11; JE; MCA; MCAF; MCP; MCP-; MCP-1; MCP1; monocyte chemoattractant protein 1; monocyte chemoattractant protein-1; monocyte chemotactic protein 1; platelet-derived growth factor-inducible protein JE; Scy; Scya2; Sig; Sigje; small inducible cytokine A2; small-inducible cytokine A2; SMC-C; SMC-CF
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391181,926,403 - 81,928,278 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1181,926,397 - 81,928,279 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381182,035,577 - 82,037,452 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,035,571 - 82,037,453 (+)Ensemblmm10GRCm38
MGSCv371181,849,079 - 81,850,954 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361181,851,769 - 81,853,422 (+)NCBIMGSCv36mm8
Celera1191,649,026 - 91,650,901 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1149.82NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Anterior Uveitis  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
acute myeloid leukemia  (IMP,ISO)
acute necrotizing pancreatitis  (ISO)
Acute-On-Chronic Liver Failure  (ISO)
adult respiratory distress syndrome  (ISO)
age related macular degeneration  (IAGP)
aggressive periodontitis  (ISO)
alcoholic hepatitis  (IMP,ISO)
allergic conjunctivitis  (IMP)
allergic disease  (ISO)
anemia  (IDA)
Animal Hepatitis  (IMP)
anterior uveitis  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
arteriosclerosis  (IEP)
asthma  (IDA,IEP,ISO)
atherosclerosis  (IDA,IEP,ISO)
autistic disorder  (ISO)
autoimmune hepatitis  (ISO)
Bacteremia  (ISO)
bacterial pneumonia  (IMP)
Behcet's disease  (ISO)
Binge Drinking  (ISO)
bipolar disorder  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Bronchial Hyperreactivity  (IEP,ISO)
bronchiolitis obliterans  (ISO)
calcinosis  (ISO)
cardiomyopathy  (ISO)
Cardiotoxicity  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (ISO)
Carrington Syndrome  (ISO)
cerebral infarction  (IEP)
Chagas disease  (ISO)
Chemical and Drug Induced Liver Injury  (IMP,ISO)
cholangitis  (ISO)
Choroidal Neovascularization  (IDA)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
Chronic Intermittent Hypoxia  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Periodontitis  (ISO)
Chronic Relapsing Experimental Autoimmune Encephalomyelitis  (ISO)
Chronic Tubulointerstitial Nephropathy  (ISO)
colitis  (ISO)
colon cancer  (ISO)
Colonic Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
congestive heart failure  (ISO)
contact dermatitis  (IEP)
Contusions  (ISO)
coronary artery disease  (ISO)
Coronary Artery Disease, Development of, in HIV  (ISO)
Coronavirus infectious disease  (ISO)
COVID-19  (ISO)
crescentic glomerulonephritis  (ISO)
Crohn's disease  (ISO)
cryptococcosis  (IEP)
cutaneous leishmaniasis  (ISO)
cystic fibrosis  (ISO)
Delayed Hypersensitivity  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (IAGP,ISO)
diabetic retinopathy  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Duchenne muscular dystrophy  (ISO)
end stage renal disease  (ISO)
Endometrial Neoplasms  (ISO)
endometriosis  (ISO)
endomyocardial fibrosis  (ISO)
Endotoxemia  (ISO)
Endotoxin-Induced Uveitis  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Autoimmune Orchitis  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Autoimmune Uveoretinitis  (IEP)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Eye Neoplasms  (IEP)
familial hyperlipidemia  (ISO)
Febrile Neutropenia  (ISO)
fibromyalgia  (ISO)
fungal infectious disease  (ISO)
gastritis  (ISO)
Geographic Atrophy  (ISO)
gestational diabetes  (ISO)
gliosarcoma  (IMP)
glomerulonephritis  (ISO)
Granulomatous Interstitial Nephritis  (ISO)
Granulomatous Vasculitis  (ISO)
Graves ophthalmopathy  (ISO)
Guillain-Barre syndrome  (ISO)
Hearing Loss, Noise-Induced  (IEP)
heart valve disease  (ISO)
hemarthrosis  (IEP)
hemolytic-uremic syndrome  (ISO)
hepatic encephalopathy  (ISO)
hepatocellular carcinoma  (IMP,ISO)
herpes simplex  (IEP)
herpes simplex virus keratitis  (IMP)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (IEP,ISO)
Hyperalgesia  (IMP,ISO)
hyperglycemia  (ISO)
hyperhomocysteinemia  (ISO)
hyperinsulinism  (ISO)
Hyperoxaluria  (ISO)
hypertension  (ISO)
Hypoxia  (ISO)
IgA glomerulonephritis  (ISO)
IgA vasculitis  (ISO)
Inflammation  (ISO)
Inflammatory Breast Neoplasms  (ISO)
influenza  (IEP)
Insulin Resistance  (IMP,ISO)
interstitial lung disease  (ISO)
interstitial nephritis  (ISO)
Intestinal Reperfusion Injury  (ISO)
intracranial aneurysm  (ISO)
intracranial vasospasm  (ISO)
invasive aspergillosis  (IMP)
Invasive Pulmonary Aspergillosis  (ISO)
ischemia  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (IEP,ISO)
Kuhnt-Junius degeneration  (ISO)
limited scleroderma  (IEP,IMP)
lipodystrophy  (ISO)
liver cirrhosis  (ISO)
liver disease  (ISO)
Liver Metastasis  (ISO)
Liver Reperfusion Injury  (IEP,IMP,ISO)
Lower Extremity Deep Vein Thrombosis  (ISO)
lung disease  (ISO)
Lung Injury  (ISO)
lupus nephritis  (ISO)
Lyme Neuroborreliosis  (ISO)
macular degeneration  (IEP,IGI,IMP,ISO)
macular retinal edema  (ISO)
membranoproliferative glomerulonephritis  (ISO)
metabolic dysfunction and alcohol associated liver disease  (IEP)
metabolic dysfunction-associated steatohepatitis  (IEP,ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
Middle East respiratory syndrome  (IEP)
Mouth Neoplasms  (ISO)
multiple myeloma  (ISO)
Multiple Organ Failure  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (ISO)
Nasal Polyps  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (IMP)
nephritis  (ISO)
neural tube defect  (ISO)
Neurodevelopmental Disorders  (ISO)
obesity  (ISO)
obstructive jaundice  (ISO)
obstructive sleep apnea  (ISO)
oral squamous cell carcinoma  (ISO)
orchitis  (ISO)
Oxygen-Induced Retinopathy  (IEP,ISO)
Pain  (ISO)
Painful Neuropathy  (IEP,ISO)
pancreatitis  (ISO)
Perennial Allergic Rhinitis  (ISO)
Peri-Implantitis  (ISO)
periapical periodontitis  (ISO)
Periodontal Cyst  (ISO)
periodontitis  (ISO)
Peripheral Nerve Injuries  (ISO)
Peritoneal Fibrosis  (IEP)
Plaque, Atherosclerotic  (IEP)
pleural disease  (ISO)
pneumocystosis  (ISO)
pneumonia  (IEP,ISO)
portal hypertension  (ISO)
Premature Obstetric Labor  (ISO)
proliferative diabetic retinopathy  (ISO)
Pulmonary Contusion  (ISO)
pulmonary edema  (ISO)
pulmonary embolism  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
Reperfusion Injury  (ISO)
Respiratory Tract Granuloma  (IEP,ISO)
Retina Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
retinal detachment  (IMP,ISO)
retinitis  (IEP)
rheumatoid arthritis  (ISO)
sarcoma  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (IEP,ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (HEP,IEP,ISO)
silicosis  (ISO)
skin melanoma  (ISO)
spina bifida  (ISO)
Spinal Cord Compression  (ISO)
squamous cell carcinoma  (ISO)
status epilepticus  (ISO)
steatotic liver disease  (IMP,ISO)
Stroke  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
temporal arteritis  (ISO)
thrombocytopenia  (ISO)
thyroid gland disease  (ISO)
Thyroid Neoplasms  (ISO)
toxic shock syndrome  (ISO)
transient cerebral ischemia  (ISO)
Transplant Rejection  (IMP,ISO)
Triple Negative Breast Neoplasms  (ISO)
tuberculosis  (ISO)
type 1 diabetes mellitus  (IEP,ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
uveitis  (ISO)
Vasculitis of the Skin  (ISO)
Venous Thrombosis  (ISO)
viral pneumonia  (IMP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-abscisic acid  (ISO)
(+)-catechin  (EXP,ISO)
(+)-pilocarpine  (EXP,ISO)
(+)-schisandrin B  (ISO)
(-)-anisomycin  (ISO)
(-)-Arctigenin  (EXP)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid  (EXP)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (EXP)
(E)-thiamethoxam  (EXP)
(R)-lipoic acid  (EXP)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (EXP,ISO)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (EXP)
1,3,5-trimethylbenzene  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,4-benzoquinone  (ISO)
1,4-naphthoquinone  (ISO)
1,4-phenylenediamine  (EXP,ISO)
1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-fluoro-2,4-dinitrobenzene  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
11-deoxycorticosterone  (ISO)
13-HPODE  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
15-acetyldeoxynivalenol  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-D  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-acetamidofluorene  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-aminopurine  (EXP)
2-arachidonoylglycerol  (ISO)
2-butoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
2-tert-butylhydroquinone  (ISO)
22-Hydroxycholesterol  (ISO)
24,25-Dihydroxyvitamin D  (ISO)
26-hydroxycholesterol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3,4-dihydroxybenzoic acid  (EXP)
3-(1H-indol-3-yl)propanoic acid  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-acetyldeoxynivalenol  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methylcholanthrene  (EXP,ISO)
3H-1,2-dithiole-3-thione  (ISO)
4',5,7-Trimethoxyflavone  (ISO)
4'-hydroxydiclofenac  (ISO)
4'-Methoxychalcone  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-Hydroxybenzophenone  (EXP)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-methylhistamine  (ISO)
4-nitro-m-cresol  (EXP)
4-nitroquinoline N-oxide  (EXP)
4-phenylbutyric acid  (EXP)
5'-S-methyl-5'-thioadenosine  (EXP)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7-ketocholesterol  (ISO)
7alpha-hydroxycholesterol  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
9-hydroxycanthin-6-one  (ISO)
Abemaciclib  (ISO)
acarbose  (ISO)
acetaldehyde  (ISO)
acetamide  (ISO)
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester  (EXP)
acetoacetic acid  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
acrylic acid  (ISO)
acrylonitrile  (ISO)
acteoside  (ISO)
actinomycin D  (ISO)
acyclovir  (ISO)
adenine  (EXP)
Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate]  (ISO)
Aeol 10150  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin G1  (EXP)
AICA ribonucleotide  (EXP,ISO)
albendazole  (ISO)
alclometasone dipropionate  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
alexidine  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
allopurinol  (ISO)
alloxan  (ISO)
alloxanthine  (ISO)
allyl alcohol  (ISO)
allyl methyl disulfide  (EXP)
alpha-hexylcinnamaldehyde  (EXP)
alpha-linolenic acid  (ISO)
alpha-naphthoflavone  (ISO)
aluminium hydroxide  (ISO)
aluminium oxide  (ISO)
AM6545  (EXP)
ambroxol  (ISO)
amiloride  (ISO)
amiodarone  (EXP,ISO)
amitrole  (ISO)
amlexanox  (EXP)
amlodipine  (ISO)
ammonium chloride  (ISO)
amprenavir  (ISO)
anagliptin  (ISO)
andrographolide  (EXP,ISO)
Anemoside B4  (ISO)
angiotensin II  (ISO)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimony(0)  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
apocynin  (ISO)
Archazolid B  (ISO)
argatroban  (EXP)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
aristolochic acids  (ISO)
Aroclor 1254  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asbestos  (EXP,ISO)
aspalathin  (ISO)
aspartame  (EXP)
astressin 2B  (EXP)
atazanavir sulfate  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
aurantio-obtusin  (EXP)
azathioprine  (ISO)
azithromycin  (EXP)
Azoxymethane  (EXP)
Bardoxolone methyl  (EXP,ISO)
baricitinib  (ISO)
barium sulfate  (ISO)
bathocuproine disulfonic acid  (ISO)
beclomethasone  (ISO)
benazepril  (ISO)
benzalkonium chloride  (EXP,ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzethonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzofurans  (ISO)
benzoic acid  (ISO)
benzylpenicillin  (EXP)
berberine  (EXP,ISO)
Bergenin  (EXP)
beta-D-glucan  (EXP)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP,ISO)
betamethasone  (ISO)
bezafibrate  (EXP,ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisoprolol  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
bisphenol AF  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP)
bleomycin A2  (EXP,ISO)
boron nitride  (ISO)
bortezomib  (ISO)
BQ 123  (EXP)
Brevianamide A  (EXP)
bromodichloromethane  (EXP)
Bucillamine  (ISO)
budesonide  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
butyric acid  (EXP,ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
Calcimycin  (EXP,ISO)
calcitriol  (EXP,ISO)
calcium atom  (ISO)
calcium dichloride  (EXP)
calcium oxalate  (ISO)
calcium silicate  (ISO)
calcium(0)  (ISO)
Calphostin C  (ISO)
camostat  (ISO)
camptothecin  (ISO)
cannabidiol  (EXP,ISO)
capsaicin  (EXP,ISO)
capsazepine  (EXP)
CARBENOXOLONE  (EXP)
carbon nanotube  (EXP,ISO)
carbonyl sulfide  (ISO)
carmustine  (ISO)
carnosine  (EXP)
carrageenan  (EXP)
catechol  (ISO)
celecoxib  (EXP,ISO)
cephaeline  (ISO)
ceric oxide  (ISO)
cerivastatin  (ISO)
ceruletide  (EXP)
CGP 52608  (ISO)
chenodeoxycholic acid  (EXP,ISO)
chlorambucil  (ISO)
chlornitrofen  (ISO)
chlorobenzene  (ISO)
chloroethene  (EXP)
chloroform  (ISO)
chlorogenic acid  (EXP)
chloroquine  (EXP,ISO)
chlorothalonil  (ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP,ISO)
choline  (EXP,ISO)
chondroitin sulfate  (ISO)
chromium atom  (ISO)
chromium(3+) trichloride  (EXP,ISO)
chromium(6+)  (ISO)
chrysin 5,7-dimethyl ether  (ISO)
ciguatoxin CTX1B  (EXP)
cilostazol  (ISO)
cimetidine  (ISO)
cis-caffeic acid  (EXP)
cisplatin  (EXP,ISO)
citric acid  (ISO)
clobenpropit  (ISO)
clofibrate  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
codeine  (ISO)
compound 48/80  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (EXP,ISO)
corticosterone  (EXP,ISO)
cortisol  (ISO)
cortisone  (EXP)
coumermycin A1  (EXP)
crocidolite asbestos  (EXP,ISO)
crotonaldehyde  (ISO)
CU-O LINKAGE  (ISO)
cucurbitacin B  (EXP)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (ISO)
D-glucose  (EXP,ISO)
dantrolene  (ISO)
dapagliflozin  (ISO)
daunorubicin  (ISO)
DDE  (ISO)
Decursin  (EXP)
deferiprone  (ISO)
deguelin  (ISO)
deoxycholic acid  (EXP,ISO)
Deoxycorticosterone acetate  (ISO)
deoxynivalenol  (EXP,ISO)
dequalinium  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (EXP)
dextran sulfate  (EXP)
dextromethorphan  (EXP,ISO)
diallyl disulfide  (EXP)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP,ISO)
dichloroacetic acid  (EXP)
dichromium trioxide  (ISO)
diclofenac  (EXP,ISO)
Didecyldimethylammonium  (EXP)
dienogest  (ISO)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP,ISO)
digitoxigenin  (ISO)
digitoxin  (ISO)
digoxigenin  (ISO)
digoxin  (ISO)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
diisopropyl fluorophosphate  (EXP,ISO)
dimemorfan  (EXP,ISO)
dimethoate  (ISO)
dimethyl fumarate  (EXP,ISO)
dimethyl sulfoxide  (ISO)
dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium  (ISO)
dimethylarsinous acid  (ISO)
diminazene diaceturate  (ISO)
dinitrogen  (ISO)
diosgenin  (EXP)
dioxygen  (EXP,ISO)
diphenyl diselenide  (ISO)
diprotium oxide  (EXP,ISO)
dipyridamole  (EXP,ISO)
disulfiram  (ISO)
dobutamine  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
edaravone  (EXP,ISO)
efavirenz  (ISO)
elemental selenium  (ISO)
ellagic acid  (ISO)
emetine  (ISO)
enalapril  (EXP,ISO)
endosulfan  (ISO)
entinostat  (ISO)
enzacamene  (ISO)
ergosta-4,6,8(14),22-tetraen-3-one  (EXP,ISO)
ergosterol  (ISO)
eriodictyol  (ISO)
erlotinib hydrochloride  (ISO)
erythromycin A  (EXP)
esculetin  (EXP)
ethambutol  (ISO)
ethanol  (EXP,ISO)
ethionamide  (ISO)
Ethyl icosapentate  (EXP)
ethylene glycol  (ISO)
ethylisopropylamiloride  (ISO)
eugenol  (EXP,ISO)
eupatilin  (EXP)
euxanthone  (ISO)
fasudil  (EXP)
febuxostat  (ISO)
felodipine  (EXP)
fenbendazole  (ISO)
fenofibrate  (EXP,ISO)
fentanyl  (ISO)
fenvalerate  (ISO)
ferric oxide  (ISO)
ferroheme b  (EXP)
ferulic acid  (EXP)
Fidarestat  (EXP)
fingolimod hydrochloride  (EXP)
fipronil  (ISO)
flavokawain B  (EXP)
flavone  (ISO)
flavonoids  (ISO)
flucloxacillin  (EXP)
fludrocortisone  (ISO)
flumequine  (EXP)
fluoranthene  (EXP)
fluoxetine  (EXP)
Fluridone  (EXP,ISO)
flutamide  (ISO)
fluticasone  (ISO)
fluvastatin  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (EXP,ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
furan  (ISO)
Fusarenone X  (EXP)
gadodiamide hydrate  (ISO)
gadolinium trichloride  (ISO)
gallic acid  (EXP,ISO)
Garcinol  (ISO)
gefitinib  (EXP,ISO)
gemcitabine  (ISO)
gemfibrozil  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
Gingerenone A  (EXP,ISO)
glucagon  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
glycerol  (ISO)
glycidol  (ISO)
glycine betaine  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhizinic acid  (EXP)
glyoxylic acid  (ISO)
glyphosate  (EXP,ISO)
gold atom  (EXP)
gold(0)  (EXP)
gossypol  (ISO)
graphene oxide  (EXP)
graphite  (EXP,ISO)
GW 4064  (EXP)
GW 501516  (EXP,ISO)
GW 7647  (ISO)
gypenoside LXXV  (EXP)
halothane  (ISO)
harmaline  (ISO)
heme b  (EXP)
hemin  (EXP)
heparin  (ISO)
hesperetin  (ISO)
Hexachloro-1,3-butadiene  (ISO)
hexadecanoic acid  (EXP,ISO)
Hexadimethrine bromide  (ISO)
histamine  (ISO)
homocysteine  (ISO)
Honokiol  (ISO)
HU-308  (ISO)
hydrochlorothiazide  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP)
hydroquinone  (EXP,ISO)
hydroxamic acid  (ISO)
hydroxychloroquine  (ISO)
ibuprofen  (EXP,ISO)
icosanoid  (ISO)
Ile(5)-angiotensin II  (ISO)
imiquimod  (ISO)
indinavir  (ISO)
indometacin  (EXP,ISO)
indoxyl sulfate  (ISO)
iodixanol  (EXP)
iodoacetic acid  (ISO)
iohexol  (EXP)
ionomycin  (ISO)
irbesartan  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
iron(III) citrate  (ISO)
Isoangustone A  (ISO)
isoeugenol  (ISO)
isoflurane  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
ivermectin  (EXP)
Jujuboside A  (EXP)
kaempferol  (EXP,ISO)
kaempferol 3-O-beta-D-glucoside  (EXP)
kainic acid  (ISO)
ketoconazole  (ISO)
L-arginine  (EXP)
L-ascorbic acid  (EXP,ISO)
L-methionine  (EXP,ISO)
lanatoside C  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
Leonurine  (EXP)
leptomycin B  (ISO)
leukotriene B4  (EXP)
leukotriene C4  (EXP)
lidocaine  (ISO)
lignin  (EXP)
limonin  (EXP)
linoleic acid  (ISO)
linuron  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (ISO)
liquiritigenin  (EXP,ISO)
liquiritin  (EXP,ISO)
lithium chloride  (EXP)
loganin  (EXP)
loliolide  (ISO)
lopinavir  (ISO)
lorcaserin  (EXP)
losartan  (EXP,ISO)
luteolin  (ISO)
LY294002  (EXP,ISO)
m-xylene  (ISO)
magnesium atom  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (EXP)
manidipine  (ISO)
mebendazole  (ISO)
Mecamylamine  (ISO)
mechlorethamine  (ISO)
meclocycline  (ISO)
medroxyprogesterone acetate  (ISO)
MeIQx  (EXP)
melamine  (ISO)
melatonin  (EXP)
mephedrone  (ISO)
mercury dichloride  (ISO)
metam  (EXP)
metformin  (EXP,ISO)
methadone  (ISO)
methapyrilene  (ISO)
methimazole  (EXP,ISO)
methionine sulfoximine  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (ISO)
methoxychlor  (ISO)
methyl beta-cyclodextrin  (EXP)
methyl methacrylate  (ISO)
methyl salicylate  (ISO)
Methylbenzethonium chloride  (ISO)
methylglyoxal  (EXP)
methylmercury chloride  (EXP,ISO)
metyrapone  (ISO)
mevalonic acid  (ISO)
microcystin-LR  (EXP,ISO)
midazolam  (EXP)
mifepristone  (ISO)
minocycline  (EXP,ISO)
mitomycin C  (ISO)
MJN110  (EXP)
MK 571  (EXP)
mono(2-ethyl-5-oxohexyl) phthalate  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (ISO)
monosodium L-glutamate  (EXP)
montelukast  (ISO)
morin  (ISO)
morphine  (ISO)
Morroniside  (EXP)
Muraglitazar  (ISO)
mycophenolic acid  (ISO)
mycotoxin  (EXP)
myricitrin  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (EXP,ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-dimethylformamide  (EXP)
N,O-dimethyltyramine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-ethyl-5'-carboxamidoadenosine  (ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP,ISO)
naloxone  (ISO)
naphthalene  (EXP)
naphthalenes  (ISO)
naproxen  (ISO)
naringin  (EXP,ISO)
nebivolol  (ISO)
nelfinavir  (ISO)
neocuproine  (EXP)
neoechinulin A  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (ISO)
nickel sulfate  (EXP,ISO)
niclosamide  (EXP,ISO)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nimesulide  (EXP,ISO)
nitrofen  (ISO)
nitrogen dioxide  (EXP,ISO)
nitroprusside  (EXP)
Nivalenol  (EXP)
nocodazole  (ISO)
nonane  (ISO)
Nonidet P-40  (ISO)
Nonylphenol  (ISO)
notoginsenoside R1  (EXP)
NS-398  (ISO)
NSC 23766  (ISO)
obeticholic acid  (EXP)
octadecanoic acid  (EXP)
okadaic acid  (EXP)
olaparib  (EXP)
oroxylin A  (ISO)
ouabain  (ISO)
oxalic acid  (ISO)
oxaliplatin  (ISO)
oxybutynin  (ISO)
oxytetracycline  (ISO)
ozone  (EXP,ISO)
Pachymic acid  (EXP,ISO)
paclitaxel  (ISO)
palmatine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (EXP,ISO)
parthenolide  (EXP,ISO)
PCB138  (EXP)
PD 168393  (ISO)
PD123319  (ISO)
pemetrexed  (ISO)
pentachlorophenol  (ISO)
pentanal  (ISO)
Pentoxifylline  (ISO)
peptidoglycan  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perindopril  (EXP,ISO)
permethrin  (EXP)
PF-956980  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (EXP,ISO)
phenformin  (ISO)
phenobarbital  (ISO)
phenol  (ISO)
phentermine  (EXP)
phenylephrine  (ISO)
phenytoin  (ISO)
phloretin  (EXP,ISO)
phlorizin  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosphatidylcholine  (EXP)
phthalic anhydride  (EXP)
phylloquinone  (ISO)
physostigmine  (EXP)
phytoestrogen  (EXP)
picolinic acid  (ISO)
pioglitazone  (EXP,ISO)
piperidines  (ISO)
Pirarubicin  (ISO)
pirinixic acid  (EXP,ISO)
pitavastatin  (EXP)
pitavastatin(1-)  (EXP)
plumbagin  (ISO)
poly(I:C)  (EXP,ISO)
polymyxin B2  (EXP,ISO)
pomalidomide  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
pravastatin  (EXP,ISO)
prednisolone  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
probenecid  (EXP,ISO)
probucol  (ISO)
procyanidin B2  (ISO)
procyanidin B3  (EXP)
progesterone  (EXP,ISO)
propan-2-ol  (EXP,ISO)
propanal  (ISO)
propidium  (ISO)
Proscillaridin  (ISO)
prostaglandin E2  (EXP,ISO)
prostaglandin I2  (ISO)
psicose  (ISO)
puromycin  (ISO)
Pyridostigmine bromide  (EXP)
pyrrolidine dithiocarbamate  (EXP,ISO)
pyrvinium  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
ramipril  (ISO)
razoxane  (ISO)
reactive oxygen species  (ISO)
rebaudioside A  (ISO)
remdesivir  (ISO)
resolvin D1  (EXP)
resolvin D2  (EXP)
resveratrol  (EXP,ISO)
ribavirin  (ISO)
rifampicin  (ISO)
rimonabant  (EXP,ISO)
ritonavir  (ISO)
rofecoxib  (ISO)
roflumilast  (ISO)
rolipram  (ISO)
rosuvastatin calcium  (ISO)
rotenone  (EXP,ISO)
rucaparib  (EXP)
rutin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
salicylic acid  (ISO)
Salinomycin  (ISO)
Salmeterol xinafoate  (ISO)
salubrinal  (EXP)
Salvianolic acid A  (EXP)
sarin  (ISO)
saroglitazar  (ISO)
sarpogrelate  (EXP,ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SCH772984  (ISO)
scoparone  (EXP,ISO)
selenium atom  (ISO)
serpentine asbestos  (EXP,ISO)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
Sinomenine  (EXP)
sirtinol  (ISO)
SL-327  (ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (ISO)
sodium benzoate  (EXP,ISO)
sodium chlorate  (ISO)
sodium chloride  (ISO)
sodium cholate  (EXP,ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
sodium hypochlorite  (ISO)
Sodium oleate  (ISO)
sodium stibogluconate  (ISO)
SR 144528  (ISO)
stavudine  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
styrene  (EXP,ISO)
succimer  (EXP,ISO)
sucrose  (EXP)
sulfaphenazole  (ISO)
sulfapyridine  (ISO)
sulfasalazine  (ISO)
sulforaphane  (EXP,ISO)
sulfur dioxide  (ISO)
sumatriptan  (ISO)
sunitinib  (EXP)
superoxide  (EXP,ISO)
tacrolimus hydrate  (EXP,ISO)
tagatose  (ISO)
tamoxifen  (EXP,ISO)
tartrazine  (ISO)
taurocholic acid  (EXP)
telmisartan  (ISO)
temozolomide  (ISO)
terameprocol  (EXP)
terbinafine  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (ISO)
testosterone  (EXP,ISO)
Tetrachlorobisphenol A  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
Tetramethylthiourea  (EXP)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
theophylline  (ISO)
thiamethoxam  (EXP)
thioacetamide  (EXP,ISO)
Tiopronin  (ISO)
Tiron  (ISO)
titanium atom  (EXP,ISO)
titanium dioxide  (EXP,ISO)
TMC-120A  (EXP)
tofacitinib  (ISO)
Tolmetin glucuronide  (ISO)
toluene  (ISO)
toluene 2,4-diisocyanate  (EXP,ISO)
topotecan  (ISO)
trans-caffeic acid  (EXP)
trans-isoeugenol  (ISO)
trans-piceid  (ISO)
tremolite asbestos  (EXP)
triamcinolone  (ISO)
tributylstannane  (EXP,ISO)
trichloroethene  (EXP,ISO)
triclosan  (EXP)
trimethyltin  (EXP)
triphenylstannane  (ISO)
Triptolide  (EXP)
triptonide  (EXP)
troglitazone  (EXP,ISO)
trovafloxacin  (EXP)
Tungsten carbide  (ISO)
tunicamycin  (EXP,ISO)
undecane  (ISO)
uranium atom  (ISO)
ursodeoxycholic acid  (EXP,ISO)
vadimezan  (EXP)
valproic acid  (ISO)
valsartan  (EXP,ISO)
vanadyl sulfate  (ISO)
vanillin  (ISO)
vemurafenib  (ISO)
venetoclax  (ISO)
verteporfin  (EXP)
vincaleukoblastine  (ISO)
vincristine  (ISO)
vitamin E  (EXP)
vorinostat  (ISO)
water  (EXP,ISO)
withaferin A  (ISO)
wortmannin  (EXP)
xanthohumol  (EXP)
XL147  (EXP)
Y-27632  (EXP)
zalcitabine  (ISO)
zidovudine  (ISO)
zileuton  (EXP)
zinc atom  (EXP,ISO)
zinc nitrate  (EXP)
zinc oxide  (EXP,ISO)
zinc protoporphyrin  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
ziram  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (TAS)
animal organ regeneration  (IEA,ISO)
antimicrobial humoral immune response mediated by antimicrobial peptide  (IBA)
astrocyte cell migration  (ISO,ISS)
cellular response to ATP  (IEA,ISO)
cellular response to dexamethasone stimulus  (IEA,ISO)
cellular response to estradiol stimulus  (IEA,ISO)
cellular response to fatty acid  (IEA,ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to glucose stimulus  (IEA,ISO)
cellular response to high density lipoprotein particle stimulus  (IEA,ISO)
cellular response to insulin stimulus  (IEA,ISO)
cellular response to interleukin-1  (IDA,IEA,ISO)
cellular response to interleukin-6  (IEA,ISO)
cellular response to lipopolysaccharide  (IDA,IEA,ISO)
cellular response to lipoprotein particle stimulus  (IEA,ISO)
cellular response to macrophage colony-stimulating factor stimulus  (IEA,ISO)
cellular response to platelet-derived growth factor stimulus  (IEA,ISO)
cellular response to retinoic acid  (IEA,ISO)
cellular response to tumor necrosis factor  (IDA,IEA,ISO)
cellular response to type II interferon  (IDA,IEA,ISO)
cellular response to xenobiotic stimulus  (IEA,ISO)
chemokine (C-C motif) ligand 2 signaling pathway  (IMP)
chemokine-mediated signaling pathway  (IBA,IEA,ISO)
chemotaxis  (IEA)
chronic inflammatory response  (IEA,ISO)
cytokine-mediated signaling pathway  (IEA,ISO)
cytoskeleton organization  (ISO)
energy homeostasis  (IMP)
eosinophil chemotaxis  (IBA)
glial cell migration  (IEA,ISO)
helper T cell extravasation  (IDA)
immune response  (IEA)
inflammatory response  (IBA,IEA)
intracellular calcium ion homeostasis  (IEA,ISO)
leukocyte migration involved in inflammatory response  (IEA,ISO)
lymphocyte chemotaxis  (IEA,ISO)
macrophage chemotaxis  (IEA,ISO,ISS)
mammary gland involution  (IEA,ISO)
maternal process involved in female pregnancy  (IEA,ISO)
maternal process involved in parturition  (IEA,ISO)
monocyte chemotaxis  (ISO)
monocyte homeostasis  (TAS)
negative regulation of angiogenesis  (IMP)
negative regulation of G1/S transition of mitotic cell cycle  (ISO)
negative regulation of glial cell apoptotic process  (ISO)
negative regulation of natural killer cell chemotaxis  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of vascular endothelial cell proliferation  (ISO)
neutrophil chemotaxis  (IEA,ISO)
osteoclast differentiation  (ISO)
positive chemotaxis  (IEA)
positive regulation of apoptotic cell clearance  (IDA)
positive regulation of calcium ion import  (ISO)
positive regulation of cell adhesion  (IEA,ISO)
positive regulation of cell migration  (IBA)
positive regulation of cell-cell adhesion  (IEA,ISO)
positive regulation of cellular extravasation  (IEA,ISO)
positive regulation of collagen biosynthetic process  (IEA,ISO)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of endothelial cell proliferation  (IEA,ISO)
positive regulation of gene expression  (IMP)
positive regulation of glutamate receptor signaling pathway  (IEA,ISO)
positive regulation of immune complex clearance by monocytes and macrophages  (IMP)
positive regulation of leukocyte mediated cytotoxicity  (IEA,ISO)
positive regulation of leukocyte migration  (IEA,ISO)
positive regulation of macrophage chemotaxis  (IDA,IEA,IMP,ISO)
positive regulation of monocyte chemotaxis  (IDA,IEA,ISO)
positive regulation of protein targeting to membrane  (IEA,ISO)
positive regulation of synaptic transmission  (IEA,ISO)
positive regulation of synaptic transmission, glutamatergic  (IDA)
positive regulation of T cell activation  (IMP)
positive regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of wound healing  (IEA,ISO)
regulation of cell shape  (ISO)
regulation of vascular endothelial growth factor production  (IMP)
response to activity  (IEA,ISO)
response to amino acid  (IEA,ISO)
response to bacterium  (IEP)
response to cyclosporin A  (IEA,ISO)
response to ethanol  (IEA,ISO)
response to gamma radiation  (IEA,ISO)
response to glucocorticoid  (IEA,ISO)
response to hypoxia  (IEA,ISO)
response to isolation stress  (IEA,ISO)
response to lipopolysaccharide  (IEA,ISO)
response to mechanical stimulus  (IEA,ISO)
response to progesterone  (IEA,ISO)
response to tumor necrosis factor  (IEA,ISO)
response to vitamin B3  (IEA,ISO)
response to wounding  (IDA)
response to xenobiotic stimulus  (IEA,ISO)
sensory perception of pain  (IDA)
transforming growth factor beta receptor signaling pathway  (IEA,ISO)
vascular endothelial growth factor receptor signaling pathway  (IEA,ISO)

Cellular Component
axon terminus  (IEA,ISO)
C-fiber  (IEA,ISO)
dendrite  (IEA,ISO)
endocytic vesicle  (IEA,ISO)
extracellular region  (IEA,ISO)
extracellular space  (HDA,IBA,IDA,IEA,ISO)
neuronal cell body  (IEA,ISO)
perikaryon  (IEA,ISO)
perinuclear region of cytoplasm  (IEA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal action potential  (IAGP)
abnormal amacrine cell morphology  (IAGP)
abnormal blood circulation  (IAGP)
abnormal Bruch membrane morphology  (IAGP)
abnormal chemokine level  (IAGP)
abnormal chemokine secretion  (IAGP)
abnormal choriocapillaris morphology  (IAGP)
abnormal conditioned taste aversion behavior  (IAGP)
abnormal cytokine level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal dendritic cell chemotaxis  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal epididymal fat pad morphology  (IAGP)
abnormal gluconeogenesis  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal gonadal fat pad morphology  (IAGP)
abnormal grip strength  (IAGP)
abnormal heart left ventricle morphology  (IAGP)
abnormal leukocyte migration  (IAGP)
abnormal macrophage chemotaxis  (IAGP)
abnormal macrophage derived foam cell morphology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal microglial cell morphology  (IAGP)
abnormal microglial cell physiology  (IAGP)
abnormal monocyte morphology  (IAGP)
abnormal Muller cell morphology  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal neutrophil physiology  (IAGP)
abnormal optic choroid morphology  (IAGP)
abnormal photoreceptor inner segment morphology  (IAGP)
abnormal physiological neovascularization  (IAGP)
abnormal posture  (IAGP)
abnormal response to cardiac infarction  (IAGP)
abnormal response to injury  (IAGP)
abnormal retina morphology  (IAGP)
abnormal retina pigment epithelium morphology  (IAGP)
abnormal retina pigmentation  (IAGP)
abnormal skeletal muscle morphology  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal touch/ nociception  (IAGP)
alcohol aversion  (IAGP)
alcohol preference  (IAGP)
choroidal neovascularization  (IAGP)
decreased adiponectin level  (IAGP)
decreased alcohol consumption  (IAGP)
decreased angiogenesis  (IAGP)
decreased body weight  (IAGP)
decreased circulating free fatty acids level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased dendritic cell number  (IAGP)
decreased fat cell size  (IAGP)
decreased grip strength  (IAGP)
decreased incidence of tumors by chemical induction  (IAGP)
decreased inflammatory response  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-1 beta secretion  (IAGP)
decreased interleukin-12b secretion  (IAGP)
decreased interleukin-4 secretion  (IAGP)
decreased interleukin-5 secretion  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased litter size  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased macrophage cell number  (IAGP)
decreased nerve conduction velocity  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased susceptibility to atherosclerosis  (IAGP)
decreased susceptibility to diet-induced hepatic steatosis  (IAGP)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
decreased susceptibility to induced colitis  (IAGP)
decreased susceptibility to neuronal excitotoxicity  (IAGP)
decreased susceptibility to type IV hypersensitivity reaction  (IAGP)
decreased susceptibility to xenobiotic induced morbidity/mortality  (IAGP)
delayed wound healing  (IAGP)
demyelination  (IAGP)
disorganized photoreceptor outer segment  (IAGP)
impaired glucose tolerance  (IAGP)
impaired macrophage chemotaxis  (IAGP)
impaired righting response  (IAGP)
impaired skeletal muscle regeneration  (IAGP)
improved glucose tolerance  (IAGP)
increased adiponectin level  (IAGP)
increased alcohol consumption  (IAGP)
increased CD4-positive, alpha-beta T cell number  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating interferon-gamma level  (IAGP)
increased circulating interleukin-10 level  (IAGP)
increased circulating leptin level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased circulating VLDL cholesterol level  (IAGP)
increased fluid intake  (IAGP)
increased IgG level  (IAGP)
increased IgG1 level  (IAGP)
increased insulin sensitivity  (IAGP)
increased interleukin-10 secretion  (IAGP)
increased macrophage cell number  (IAGP)
increased microglial cell activation  (IAGP)
increased muscle weight  (IAGP)
increased neutrophil cell number  (IAGP)
increased osteoclast cell number  (IAGP)
increased percent body fat/body weight  (IAGP)
increased susceptibility to age-related retinal degeneration  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to diet-induced obesity  (IAGP)
increased susceptibility to infection induced morbidity/mortality  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
increased total fat pad weight  (IAGP)
increased vasodilation  (IAGP)
lipofuscinosis  (IAGP)
neuron degeneration  (IAGP)
no abnormal phenotype detected  (IEA)
premature tooth eruption  (IAGP)
retina deposits  (IAGP)
retina outer nuclear layer degeneration  (IAGP)
retina photoreceptor degeneration  (IAGP)
retina pigment epithelium atrophy  (IAGP)
retina pigment epithelium hyperplasia  (IAGP)
skeletal muscle necrosis  (IAGP)
variable depigmentation  (IAGP)
References

References - curated
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98. Curcumin supplementation lowers TNF-alpha, IL-6, IL-8, and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats. Jain SK, etal., Antioxid Redox Signal. 2009 Feb;11(2):241-9.
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PMID:22814670   PMID:22815949   PMID:22837723   PMID:22840843   PMID:22841816   PMID:22851704   PMID:22904274   PMID:22907530   PMID:22912822   PMID:22927430   PMID:22960654   PMID:22964851  
PMID:22976830   PMID:22985398   PMID:23012479   PMID:23019193   PMID:23022404   PMID:23033370   PMID:23040664   PMID:23041279   PMID:23043544   PMID:23074204   PMID:23085145   PMID:23129286  
PMID:23129755   PMID:23160182   PMID:23172918   PMID:23185004   PMID:23204071   PMID:23232206   PMID:23247123   PMID:23254193   PMID:23269787   PMID:23322734   PMID:23395675   PMID:23416685  
PMID:23438786   PMID:23519994   PMID:23527025   PMID:23536638   PMID:23542035   PMID:23547114   PMID:23553711   PMID:23562605   PMID:23591836   PMID:23603910   PMID:23637822   PMID:23651238  
PMID:23659480   PMID:23677863   PMID:23686489   PMID:23752092   PMID:23762028   PMID:23821228   PMID:23866683   PMID:23892723   PMID:23956504   PMID:23959857   PMID:23966300   PMID:23972264  
PMID:23977220   PMID:23982842   PMID:24006456   PMID:24024606   PMID:24067473   PMID:24101375   PMID:24122510   PMID:24129162   PMID:24135048   PMID:24252211   PMID:24282281   PMID:24302580  
PMID:24307731   PMID:24312451   PMID:24319288   PMID:24374218   PMID:24388986   PMID:24391920   PMID:24405593   PMID:24416305   PMID:24420912   PMID:24428529   PMID:24444311   PMID:24453432  
PMID:24481979   PMID:24534280   PMID:24550391   PMID:24600037   PMID:24632850   PMID:24639350   PMID:24639355   PMID:24674583   PMID:24709779   PMID:24748435   PMID:24780906   PMID:24890717  
PMID:24920622   PMID:24921973   PMID:24947528   PMID:24952082   PMID:24975165   PMID:25005117   PMID:25012628   PMID:25040187   PMID:25041478   PMID:25063874   PMID:25108845   PMID:25129504  
PMID:25130440   PMID:25133509   PMID:25170996   PMID:25209862   PMID:25242651   PMID:25263281   PMID:25271254   PMID:25312961   PMID:25319795   PMID:25329075   PMID:25337938   PMID:25339674  
PMID:25340820   PMID:25341493   PMID:25342612   PMID:25349202   PMID:25360868   PMID:25406462   PMID:25447050   PMID:25449579   PMID:25450249   PMID:25474480   PMID:25495686   PMID:25497142  
PMID:25537494   PMID:25545116   PMID:25585624   PMID:25603464   PMID:25620282   PMID:25626968   PMID:25651887   PMID:25663168   PMID:25695619   PMID:25738264   PMID:25739439   PMID:25765592  
PMID:25769110   PMID:25769927   PMID:25780042   PMID:25847238   PMID:25873126   PMID:25875776   PMID:25895671   PMID:26056232   PMID:26058873   PMID:26112421   PMID:26146082   PMID:26149093  
PMID:26167165   PMID:26205994   PMID:26305552   PMID:26311113   PMID:26332085   PMID:26358505   PMID:26401006   PMID:26411367   PMID:26413869   PMID:26422754   PMID:26431741   PMID:26432869  
PMID:26432893   PMID:26438362   PMID:26474702   PMID:26476037   PMID:26476672   PMID:26515692   PMID:26620890   PMID:26626357   PMID:26631474   PMID:26632270   PMID:26661648   PMID:26671708  
PMID:26740548   PMID:26766793   PMID:26794131   PMID:26834744   PMID:26851629   PMID:26879207   PMID:26910882   PMID:26927370   PMID:26930384   PMID:26973110   PMID:26979087   PMID:26992431  
PMID:26996665   PMID:27030762   PMID:27053419   PMID:27072606   PMID:27079875   PMID:27102570   PMID:27114284   PMID:27129293   PMID:27146354   PMID:27150016   PMID:27178133   PMID:27181207  
PMID:27189410   PMID:27216177   PMID:27260136   PMID:27273604   PMID:27300479   PMID:27354473   PMID:27376197   PMID:27392463   PMID:27392713   PMID:27431088   PMID:27488527   PMID:27508875  
PMID:27530322   PMID:27564257   PMID:27569912   PMID:27572255   PMID:27586429   PMID:27601660   PMID:27609570   PMID:27619518   PMID:27640148   PMID:27659424   PMID:27733491   PMID:27760760  
PMID:27777976   PMID:27809288   PMID:27820834   PMID:27827374   PMID:27878909   PMID:27940088   PMID:27967209   PMID:28017131   PMID:28054838   PMID:28065589   PMID:28077158   PMID:28088610  
PMID:28092793   PMID:28096401   PMID:28117437   PMID:28125278   PMID:28162974   PMID:28177896   PMID:28242024   PMID:28244492   PMID:28290520   PMID:28330776   PMID:28366204   PMID:28383062  
PMID:28391993   PMID:28431906   PMID:28516946   PMID:28574501   PMID:28580280   PMID:28593659   PMID:28716963   PMID:28778590   PMID:28782174   PMID:28836736   PMID:28837800   PMID:28874170  
PMID:28887124   PMID:28923684   PMID:28931761   PMID:28951461   PMID:28964716   PMID:28978634   PMID:29084208   PMID:29106985   PMID:29127344   PMID:29170400   PMID:29176798   PMID:29295871  
PMID:29378914   PMID:29379059   PMID:29477409   PMID:29535277   PMID:29615957   PMID:29739958   PMID:29798841   PMID:29864522   PMID:29872089   PMID:29925518   PMID:29953616   PMID:29975947  
PMID:29993042   PMID:30054581   PMID:30146158   PMID:30160348   PMID:30173917   PMID:30188257   PMID:30209078   PMID:30248108   PMID:30269986   PMID:30322871   PMID:30397205   PMID:30447270  
PMID:30479274   PMID:30484883   PMID:30552233   PMID:30553275   PMID:30571348   PMID:30571728   PMID:30599182   PMID:30683620   PMID:30684382   PMID:30687013   PMID:30730243   PMID:30861639  
PMID:30905786   PMID:30909920   PMID:30944305   PMID:30952712   PMID:31003094   PMID:31048100   PMID:31091126   PMID:31137011   PMID:31141500   PMID:31169521   PMID:31186412   PMID:31189648  
PMID:31246581   PMID:31306468   PMID:31399604   PMID:31424112   PMID:31428084   PMID:31442403   PMID:31484731   PMID:31494101   PMID:31519886   PMID:31536479   PMID:31557402   PMID:31618101  
PMID:31677795   PMID:31721276   PMID:31746387   PMID:31774703   PMID:31837540   PMID:31900336   PMID:31922885   PMID:31937758   PMID:32017036   PMID:32049021   PMID:32060374   PMID:32103760  
PMID:32130954   PMID:32176388   PMID:32182218   PMID:32198221   PMID:32212902   PMID:32213564   PMID:32238474   PMID:32290105   PMID:32355198   PMID:32391790   PMID:32508844   PMID:32518084  
PMID:32553806   PMID:32562599   PMID:32603611   PMID:32809188   PMID:32811643   PMID:32861799   PMID:33036616   PMID:33038331   PMID:33106688   PMID:33108405   PMID:33148888   PMID:33160071  
PMID:33212319   PMID:33228784   PMID:33239787   PMID:33300045   PMID:33373623   PMID:33503407   PMID:33505018   PMID:33540898   PMID:33638773   PMID:33724710   PMID:33760886   PMID:33763067  
PMID:33813049   PMID:33927191   PMID:34003466   PMID:34135893   PMID:34171415   PMID:34259011   PMID:34348145   PMID:34395439   PMID:34423781   PMID:34459091   PMID:34560074   PMID:34593796  
PMID:34698088   PMID:34797523   PMID:34830041   PMID:34831339   PMID:34874922   PMID:34925336   PMID:34975857   PMID:34992132   PMID:35143888   PMID:35311578   PMID:35328727   PMID:35493520  
PMID:35658715   PMID:35691449   PMID:35735018   PMID:35775484   PMID:35820932   PMID:35859175   PMID:35914622   PMID:35966584   PMID:36042496   PMID:36063964   PMID:36076499   PMID:36207400  
PMID:36240949   PMID:36374225   PMID:36414671   PMID:36522157   PMID:36584405   PMID:36685592   PMID:36702545   PMID:36752206   PMID:36861669   PMID:36996219   PMID:37012245   PMID:37085605  
PMID:37108548   PMID:37155343   PMID:37175837   PMID:37176074   PMID:37188818   PMID:37195045   PMID:37208442   PMID:37225978   PMID:37284790   PMID:37316349   PMID:37338984   PMID:37497210  
PMID:37652021   PMID:37697486   PMID:37878486   PMID:37914098   PMID:37931808   PMID:37935566   PMID:38016488   PMID:38029541   PMID:38035640   PMID:38081433   PMID:38153396   PMID:38169294  
PMID:38206985   PMID:38281222   PMID:38320300   PMID:38351345   PMID:38367237   PMID:38368631   PMID:38395995   PMID:38428413   PMID:38510961   PMID:38593506   PMID:38594391   PMID:38653356  
PMID:38709635   PMID:38732210   PMID:38816193   PMID:38825533   PMID:38952044   PMID:39128813   PMID:39475511   PMID:39528947   PMID:39581458   PMID:39660056   PMID:39939762   PMID:40058724  
PMID:40200300  


Genomics

Comparative Map Data
Ccl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391181,926,403 - 81,928,278 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1181,926,397 - 81,928,279 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381182,035,577 - 82,037,452 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,035,571 - 82,037,453 (+)Ensemblmm10GRCm38
MGSCv371181,849,079 - 81,850,954 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361181,851,769 - 81,853,422 (+)NCBIMGSCv36mm8
Celera1191,649,026 - 91,650,901 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1149.82NCBI
CCL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381734,255,285 - 34,257,203 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1734,255,274 - 34,257,208 (+)Ensemblhg38GRCh38
GRCh371732,582,304 - 32,584,222 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361729,606,409 - 29,608,335 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341729,606,408 - 29,608,331NCBI
Celera1729,492,130 - 29,494,042 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1728,767,599 - 28,769,525 (+)NCBIHuRef
CHM1_11732,646,183 - 32,648,095 (+)NCBICHM1_1
T2T-CHM13v2.01735,201,562 - 35,203,480 (+)NCBIT2T-CHM13v2.0
Ccl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81067,503,077 - 67,504,875 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1067,503,077 - 67,504,875 (+)EnsemblGRCr8
mRatBN7.21067,005,424 - 67,007,222 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1067,005,424 - 67,007,226 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1071,626,649 - 71,628,447 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01071,131,996 - 71,133,794 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01066,593,121 - 66,594,919 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01069,412,065 - 69,413,863 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1069,412,017 - 69,413,870 (+)Ensemblrn6Rnor6.0
Rnor_5.01069,047,091 - 69,048,889 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41070,256,263 - 70,258,061 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1065,952,968 - 65,954,766 (+)NCBICelera
Cytogenetic Map10q26NCBI
CCL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21930,208,206 - 30,210,212 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11732,089,476 - 32,091,422 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01722,528,154 - 22,530,091 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11722,821,336 - 22,823,271 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1722,820,890 - 22,823,384 (-)EnsemblpanPan2panpan1.1
CCL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1939,008,187 - 39,009,932 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha938,231,467 - 38,233,216 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0939,822,383 - 39,824,132 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1938,608,720 - 38,610,469 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0938,897,447 - 38,899,196 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0938,976,777 - 38,978,526 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
CCL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1240,798,109 - 40,800,026 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11240,798,109 - 40,800,013 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21242,514,202 - 42,516,108 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103242710
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11627,763,354 - 27,765,437 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1627,763,555 - 27,765,416 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660752,254,637 - 2,256,540 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ccl2
61 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:152
Count of miRNA genes:139
Interacting mature miRNAs:147
Transcripts:ENSMUST00000000193, ENSMUST00000124479
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
1301078Alcp2_malcohol preference locus 2 (mouse)Not determined117220979684731462Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
12903994Opfaq3_mopen field activity QTL 3 (mouse)117373754182069425Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117757387399377820Mouse

Markers in Region
Ccl2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381182,035,650 - 82,037,153UniSTSGRCm38
MGSCv371181,849,152 - 81,850,655UniSTSGRCm37
Celera1191,649,099 - 91,650,602UniSTS
Cytogenetic Map11C-E1UniSTS
AI323594  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381182,037,075 - 82,037,203UniSTSGRCm38
MGSCv371181,850,577 - 81,850,705UniSTSGRCm37
Celera1191,650,524 - 91,650,652UniSTS
Cytogenetic Map11C-E1UniSTS
Whitehead/MRC_RH111041.73UniSTS
PMC114617P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381182,036,933 - 82,037,312UniSTSGRCm38
MGSCv371181,850,435 - 81,850,814UniSTSGRCm37
Celera1191,650,382 - 91,650,761UniSTS
Cytogenetic Map11C-E1UniSTS
PMC145384P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381182,036,500 - 82,037,142UniSTSGRCm38
MGSCv371181,850,002 - 81,850,644UniSTSGRCm37
Celera1191,649,949 - 91,650,591UniSTS
Cytogenetic Map11C-E1UniSTS
PMC150930P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381182,036,521 - 82,036,986UniSTSGRCm38
MGSCv371181,850,023 - 81,850,488UniSTSGRCm37
Celera1191,649,970 - 91,650,435UniSTS
Cytogenetic Map11C-E1UniSTS
PMC153814P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381182,036,533 - 82,037,201UniSTSGRCm38
MGSCv371181,850,035 - 81,850,703UniSTSGRCm37
Celera1191,649,982 - 91,650,650UniSTS
Cytogenetic Map11C-E1UniSTS
PMC212800P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381182,035,708 - 82,036,528UniSTSGRCm38
MGSCv371181,849,210 - 81,850,030UniSTSGRCm37
Celera1191,649,157 - 91,649,977UniSTS
Cytogenetic Map11C-E1UniSTS
Scya2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381182,036,130 - 82,036,221UniSTSGRCm38
MGSCv371181,849,632 - 81,849,723UniSTSGRCm37
Celera1191,649,579 - 91,649,670UniSTS
Cytogenetic Map11C-E1UniSTS
cM Map1146.5UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_011333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF065929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF065930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF065931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF065932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF065933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ238892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK132590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL626807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC055070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC145867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC145869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ917241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M19681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OL792764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U12470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000000193   ⟹   ENSMUSP00000000193
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1181,926,397 - 81,928,279 (+)Ensembl
GRCm38.p6 Ensembl1182,035,571 - 82,037,453 (+)Ensembl
Ensembl Acc Id: ENSMUST00000124479
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1181,926,436 - 81,928,276 (+)Ensembl
GRCm38.p6 Ensembl1182,035,610 - 82,037,450 (+)Ensembl
RefSeq Acc Id: NM_011333   ⟹   NP_035463
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391181,926,403 - 81,928,278 (+)NCBI
GRCm381182,035,577 - 82,037,452 (+)ENTREZGENE
MGSCv371181,849,079 - 81,850,954 (+)RGD
Celera1191,649,026 - 91,650,901 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_035463   ⟸   NM_011333
- Peptide Label: precursor
- UniProtKB: Q9QYD7 (UniProtKB/Swiss-Prot),   P10148 (UniProtKB/Swiss-Prot),   Q5SVU3 (UniProtKB/TrEMBL),   Q3U5S8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000000193   ⟸   ENSMUST00000000193
Protein Domains
Chemokine interleukin-8-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10148-F1-model_v2 AlphaFold P10148 1-148 view protein structure

Promoters
RGD ID:6820569
Promoter ID:MM_KWN:8832
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Liver,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000001659,   OTTMUST00000001660
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361181,848,899 - 81,849,399 (+)MPROMDB
RGD ID:6848993
Promoter ID:MM_XEF:1192
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:NM_001003297,   NM_001032821,   NM_001032851,   NM_001081931,   NM_001082294,   NM_001132340,   NM_001173538,   NM_002982,   NM_174006,   NM_214214
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361181,849,869 - 81,850,369 (+)MPROMDB
RGD ID:8675822
Promoter ID:EPDNEW_M15941
Type:multiple initiation site
Name:Ccl2_1
Description:Mus musculus chemokine (C-C motif) ligand 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381182,035,577 - 82,035,637EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98259 AgrOrtholog
Ensembl Genes ENSMUSG00000035385 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000000193 ENTREZGENE
  ENSMUST00000000193.6 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot
  Chemokine_CC_CS UniProtKB/Swiss-Prot
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot
  Interleukin_8-like_sf UniProtKB/Swiss-Prot
KEGG Report mmu:20296 UniProtKB/Swiss-Prot
MGD MGI:98259 ENTREZGENE
NCBI Gene 20296 ENTREZGENE
PANTHER C-C MOTIF CHEMOKINE 2 UniProtKB/Swiss-Prot
  PTHR12015 UniProtKB/Swiss-Prot
Pfam IL8 UniProtKB/Swiss-Prot
PhenoGen Ccl2 PhenoGen
PROSITE SMALL_CYTOKINES_CC UniProtKB/Swiss-Prot
SMART SCY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot
UniProt CCL2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3U5L6_MOUSE UniProtKB/TrEMBL
  Q3U5S8 ENTREZGENE, UniProtKB/TrEMBL
  Q5SVU3 ENTREZGENE, UniProtKB/TrEMBL
  Q7TMS1_MOUSE UniProtKB/TrEMBL
  Q9QYD7 ENTREZGENE
UniProt Secondary Q9QYD7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-27 Ccl2  C-C motif chemokine ligand 2  Ccl2  chemokine (C-C motif) ligand 2  Symbol and/or name change 5135510 APPROVED