Scnn1a (sodium channel, nonvoltage-gated 1 alpha) - Rat Genome Database

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Gene: Scnn1a (sodium channel, nonvoltage-gated 1 alpha) Mus musculus
Analyze
Symbol: Scnn1a
Name: sodium channel, nonvoltage-gated 1 alpha
RGD ID: 11269
MGI Page MGI
Description: Enables WW domain binding activity and ligand-gated sodium channel activity. Contributes to sodium channel activity. Involved in intracellular sodium ion homeostasis and sodium ion import across plasma membrane. Acts upstream of or within cellular response to aldosterone and sodium ion transport. Located in cytosol and external side of plasma membrane. Part of sodium channel complex. Is expressed in several structures, including colon; heart; hindgut; liver; and lung. Human ortholog(s) of this gene implicated in Liddle syndrome; bronchiectasis 2; and pseudohypoaldosteronism. Orthologous to human SCNN1A (sodium channel epithelial 1 subunit alpha).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-ENaC; alpha-NaCH; amiloride-sensitive epithelial sodium channel; amiloride-sensitive sodium channel subunit alpha; ENaC; ENaC alpha; epithelial Na(+) channel subunit alpha; epithelial sodium channel alpha subunit; mEN; mENaC; nonvoltage-gated sodium channel 1 subunit alpha; Sc; SCNEA; Scnn1; sodium channel, nonvoltage-gated, type I, alpha polypeptide
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396125,286,657 - 125,321,906 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6125,297,622 - 125,321,906 (+)EnsemblGRCm39 Ensembl
GRCm386125,314,271 - 125,344,943 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6125,320,659 - 125,344,943 (+)EnsemblGRCm38mm10GRCm38
MGSCv376125,271,358 - 125,294,961 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366125,287,472 - 125,310,562 (+)NCBIMGSCv36mm8
Celera6126,992,384 - 127,015,966 (+)NCBICelera
Cytogenetic Map6F3NCBI
cM Map659.32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-nitropyrene  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-dinitrotoluene  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
8-(4-chlorophenylthio)-cAMP  (ISO)
8-(4-chlorophenylthio)-cGMP  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldosterone  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allethrin  (ISO)
amiloride  (EXP,ISO)
ammonium chloride  (ISO)
amphotericin B  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
azoxystrobin  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A5  (ISO)
bromobenzene  (ISO)
butanal  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
calcitriol  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
crocidolite asbestos  (EXP)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
DDE  (ISO)
dexamethasone  (EXP)
dextran sulfate  (EXP)
dibenzofurans  (EXP)
dicrotophos  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
ethanol  (ISO)
farglitazar  (ISO)
fenthion  (EXP)
fenvalerate  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (ISO)
glyphosate  (ISO)
hexachlorobenzene  (ISO)
imidacloprid  (ISO)
indole-3-methanol  (ISO)
iodide salt  (ISO)
isotretinoin  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lithium atom  (ISO)
lithium chloride  (ISO)
lithium hydride  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methoxychlor  (ISO)
methylmercury(1+)  (ISO)
nitrates  (ISO)
nitrofen  (ISO)
orphenadrine  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (EXP)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
potassium atom  (ISO)
progesterone  (ISO)
propranolol  (ISO)
prothioconazole  (ISO)
pyrethrins  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (EXP,ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
terbutaline  (ISO)
testosterone  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP,ISO)
thiabendazole  (ISO)
thioacetamide  (ISO)
thiourea  (ISO)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of epigenetically regulated genes that predict patient outcome in neuroblastoma. Caren H, etal., BMC Cancer. 2011 Feb 11;11:66.
2. Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1. Chang SS, etal., Nat Genet. 1996 Mar;12(3):248-53.
3. Impact of alphaENaC polymorphisms on the risk of ischemic cerebrovascular events: a multicenter case-control study. Hsieh K, etal., Clin Chem. 2005 Jun;51(6):952-6. Epub 2005 Feb 25.
4. Increased expression and apical targeting of renal ENaC subunits in puromycin aminonucleoside-induced nephrotic syndrome in rats. Kim SW, etal., Am J Physiol Renal Physiol. 2004 May;286(5):F922-35. Epub 2004 Jan 6.
5. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Mouse chromosomal location of three epithelial sodium channel subunit genes and an apical sodium chloride cotransporter gene. Pathak BG, etal., Genomics 1996 Apr 1;33(1):124-7.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7896277   PMID:8107805   PMID:8575777   PMID:8589728   PMID:9284273   PMID:9326675   PMID:9374403   PMID:9990093   PMID:10212229   PMID:10232677   PMID:10349636   PMID:10355613  
PMID:10409305   PMID:10419016   PMID:10760060   PMID:11042159   PMID:11076861   PMID:11208532   PMID:11217851   PMID:11244092   PMID:11380824   PMID:11406278   PMID:11742982   PMID:11857811  
PMID:11918703   PMID:12176733   PMID:12381779   PMID:12393794   PMID:12424229   PMID:12477808   PMID:12477932   PMID:12576470   PMID:12770839   PMID:12876281   PMID:12897071   PMID:12925696  
PMID:14625286   PMID:14701851   PMID:14703519   PMID:14761862   PMID:15007080   PMID:15047694   PMID:15096495   PMID:15123669   PMID:15166222   PMID:15261163   PMID:15308680   PMID:15569663  
PMID:15623897   PMID:15636635   PMID:15753079   PMID:15908426   PMID:15914781   PMID:15953355   PMID:16141072   PMID:16141073   PMID:16166161   PMID:16192419   PMID:16203727   PMID:16236820  
PMID:16407190   PMID:16574660   PMID:16585520   PMID:16636056   PMID:16829523   PMID:16912051   PMID:16941024   PMID:16985003   PMID:16985514   PMID:17192279   PMID:17199078   PMID:17332896  
PMID:17513453   PMID:17522058   PMID:17686956   PMID:17715136   PMID:17855354   PMID:17913833   PMID:17932048   PMID:17967898   PMID:17977920   PMID:18032549   PMID:18039670   PMID:18045816  
PMID:18348164   PMID:18456231   PMID:18586672   PMID:18687683   PMID:18981174   PMID:19144862   PMID:19158091   PMID:19322198   PMID:19367412   PMID:19477942   PMID:19491102   PMID:19587447  
PMID:19635986   PMID:19793956   PMID:19864429   PMID:20026617   PMID:20107438   PMID:20110346   PMID:20159978   PMID:20389022   PMID:20410134   PMID:20427473   PMID:20434520   PMID:20453031  
PMID:20504903   PMID:20587418   PMID:20813869   PMID:20868778   PMID:20921400   PMID:20947633   PMID:20966128   PMID:20974852   PMID:21051735   PMID:21075848   PMID:21106690   PMID:21123494  
PMID:21267068   PMID:21284860   PMID:21367859   PMID:21413931   PMID:21448181   PMID:21505443   PMID:21624334   PMID:21743028   PMID:21873635   PMID:21918182   PMID:21997487   PMID:22087315  
PMID:22237799   PMID:22357920   PMID:22408250   PMID:22449024   PMID:22496413   PMID:22622459   PMID:22647633   PMID:22665796   PMID:22705055   PMID:22729284   PMID:22952456   PMID:22983350  
PMID:23029554   PMID:23033373   PMID:23144453   PMID:23152297   PMID:23264685   PMID:23348737   PMID:23362276   PMID:23404498   PMID:23460285   PMID:23558339   PMID:23684652   PMID:23741519  
PMID:23871693   PMID:23926181   PMID:24026182   PMID:24070375   PMID:24281140   PMID:24419567   PMID:24480829   PMID:24914548   PMID:24952961   PMID:25029038   PMID:25187622   PMID:25389295  
PMID:25391901   PMID:25415435   PMID:25520009   PMID:25531136   PMID:25551628   PMID:25621930   PMID:25774517   PMID:25925258   PMID:25941340   PMID:25972513   PMID:26207612   PMID:26268211  
PMID:26582762   PMID:26701978   PMID:26887833   PMID:27606670   PMID:27802315   PMID:28100747   PMID:28137758   PMID:28283476   PMID:28365586   PMID:28468944   PMID:28527294   PMID:28646163  
PMID:28676575   PMID:28847650   PMID:28950003   PMID:28994389   PMID:29021227   PMID:29070571   PMID:29074490   PMID:29187368   PMID:29212953   PMID:29574718   PMID:29779889   PMID:29858246  
PMID:29987101   PMID:30154237   PMID:30628684   PMID:30659401   PMID:30952430   PMID:31113930   PMID:31252520   PMID:31382627   PMID:31871197   PMID:32079677   PMID:32229307   PMID:32281419  
PMID:32325033   PMID:32817119   PMID:34863181   PMID:35339489   PMID:35341793   PMID:37045597   PMID:37279066   PMID:37830556   PMID:37909221   PMID:38349781  


Genomics

Comparative Map Data
Scnn1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396125,286,657 - 125,321,906 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6125,297,622 - 125,321,906 (+)EnsemblGRCm39 Ensembl
GRCm386125,314,271 - 125,344,943 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6125,320,659 - 125,344,943 (+)EnsemblGRCm38mm10GRCm38
MGSCv376125,271,358 - 125,294,961 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366125,287,472 - 125,310,562 (+)NCBIMGSCv36mm8
Celera6126,992,384 - 127,015,966 (+)NCBICelera
Cytogenetic Map6F3NCBI
cM Map659.32NCBI
SCNN1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,346,847 - 6,377,359 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,346,843 - 6,377,730 (-)EnsemblGRCh38hg38GRCh38
GRCh37126,456,013 - 6,486,525 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,326,274 - 6,354,976 (-)NCBINCBI36Build 36hg18NCBI36
Build 34126,326,275 - 6,354,976NCBI
Celera128,072,686 - 8,103,776 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef126,309,328 - 6,340,388 (-)NCBIHuRef
CHM1_1126,455,271 - 6,485,705 (-)NCBICHM1_1
T2T-CHM13v2.0126,356,269 - 6,387,417 (-)NCBIT2T-CHM13v2.0
Scnn1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,809,187 - 159,832,409 (+)NCBIGRCr8
mRatBN7.24158,122,962 - 158,146,184 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4158,122,962 - 158,146,181 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4164,352,580 - 164,375,779 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04160,135,500 - 160,158,705 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,774,454 - 158,797,542 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,834,339 - 157,860,472 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,836,912 - 157,860,049 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,853,710 - 224,877,459 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44161,445,936 - 161,469,267 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14161,690,871 - 161,714,200 (+)NCBI
Celera4146,859,208 - 146,882,414 (+)NCBICelera
RH 3.4 Map41000.7RGD
Cytogenetic Map4q42NCBI
Scnn1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554133,999,613 - 4,023,596 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554134,000,083 - 4,023,596 (-)NCBIChiLan1.0ChiLan1.0
SCNN1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21011,906,576 - 11,936,618 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11211,903,334 - 11,934,030 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0126,475,723 - 6,506,443 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1126,392,354 - 6,423,118 (-)NCBIpanpan1.1PanPan1.1panPan2
SCNN1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,612,206 - 38,638,212 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,612,194 - 38,638,980 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha277,976,259 - 8,002,278 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02738,968,240 - 38,994,329 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2738,969,121 - 38,994,321 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12738,840,880 - 38,866,869 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,882,321 - 38,908,328 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,455,013 - 7,481,038 (-)NCBIUU_Cfam_GSD_1.0
Scnn1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,703,982 - 102,735,845 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367091,377,831 - 1,403,833 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367091,377,852 - 1,403,398 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCNN1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl564,285,015 - 64,313,612 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1564,287,529 - 64,312,917 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,749,072 - 66,773,949 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SCNN1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1116,384,073 - 6,418,620 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl116,383,956 - 6,416,337 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660631,817,244 - 1,851,507 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Scnn1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248603,126,379 - 3,145,043 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248603,123,676 - 3,152,217 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Scnn1a
1147 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2375
Count of miRNA genes:624
Interacting mature miRNAs:759
Transcripts:ENSMUST00000081440, ENSMUST00000175966, ENSMUST00000176110, ENSMUST00000176365, ENSMUST00000176442, ENSMUST00000176655, ENSMUST00000177329
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648696934125336963Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648703490125333748Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683690851146954059Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692584287146330736Mouse
1301292Cfbw2_mcystic fibrosis body weight 2 (mouse)Not determined694981612128981699Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696324286130324483Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696324286130324483Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96632912146535124Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96632912146535124Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696632912146535124Mouse
10043923Bhr7_mbronchial hyperresponsiveness 7 (mouse)Not determined698219814132219938Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698483798145881170Mouse
1301923Lith6_mlithogenic gene 6 (mouse)Not determined698694477132694676Mouse
1301915Chab3_mcholesterol absorption 3 (mouse)Not determined698908709132916997Mouse
1302131Bmd8_mbone mineral density 8 (mouse)Not determined699132089133132228Mouse
1300887Pabr1_mplasma apolipoprotein B (human) regulator 1 (mouse)Not determined6103754405136400690Mouse
1301509Sluc3_msusceptibility to lung cancer 3 (mouse)Not determined6104480321127019938Mouse
1357806Aaj3_manxiety in A/J 3 (mouse)Not determined6104480321136400690Mouse
10412207Cypr5_mcytokine production 5 (mouse)Not determined6110815180144815323Mouse
13463481Mcvq14_mmean corpuscular volume QTL 14 (mouse)6111142448145142541Mouse
10043891Tilss4_mTNF-induced lethal shock susceptibility 3 (mouse)Not determined6112246918125333748Mouse
11252138Clas1_mcarcinogen-induced lung adenoma susceptibility 1 (mouse)6112246918146954059Mouse
4140980Mvwf2_mmodifier of von Willebrand factor 2 (mouse)Not determined114345693145601739Mouse
1301658Radpf3_mradiation pulmonary fibrosis 3 (mouse)Not determined6115219814146330736Mouse
4141889Qui_mquinine sensitivity, taste (mouse)Not determined115546805149549364Mouse
4141194Cyx_mcycloheximide tasting (mouse)Not determined115546805149549364Mouse
4141295Rua_mraffinose acetate tasting (mouse)Not determined115546805149549364Mouse
1301927Etohcta6_methanol conditioned taste aversion 6 (mouse)Not determined6115578005149578150Mouse
1301083Bhr5_mbronchial hyperresponsiveness 5 (mouse)Not determined6115694477132578150Mouse
4141064Ath37_matherosclerosis 37 (mouse)Not determined6116641858128495988Mouse
4142079Skmw15_mskeletal muscle weight 15 (mouse)Not determined6116829851149588044Mouse
1301152Athsq2_matherosclerosis susceptibility QTL 2 (mouse)Not determined6117059949149588044Mouse
1301804Bulb2_mbulb size 2 (mouse)Not determined6120416806149588044Mouse
10449436Pas17_mpulmonary adenoma susceptibility 17 (mouse)6124334273145601739Mouse
1302089Wta2_mweight adult 2 (mouse)Not determined6125269523149588044Mouse

Markers in Region
EC218RL  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386125,327,997 - 125,328,170UniSTSGRCm38
MGSCv376125,278,015 - 125,278,188UniSTSGRCm37
Celera6126,999,040 - 126,999,213UniSTS
Cytogenetic Map6F3UniSTS
cM Map660.5UniSTS
EC351RL  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386125,328,018 - 125,328,170UniSTSGRCm38
MGSCv376125,278,036 - 125,278,188UniSTSGRCm37
Celera6126,999,061 - 126,999,213UniSTS
Cytogenetic Map6F3UniSTS
cM Map660.5UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001406028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001406031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017321471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030255276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC140324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF112185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF228802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF346304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK140389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC040814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC049952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC133688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC133689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U52006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000081440   ⟹   ENSMUSP00000080164
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6125,298,303 - 125,321,906 (+)Ensembl
GRCm38.p6 Ensembl6125,321,340 - 125,344,943 (+)Ensembl
RefSeq Acc Id: ENSMUST00000175966   ⟹   ENSMUSP00000135551
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6125,298,242 - 125,321,352 (+)Ensembl
GRCm38.p6 Ensembl6125,321,279 - 125,344,389 (+)Ensembl
RefSeq Acc Id: ENSMUST00000176110   ⟹   ENSMUSP00000134940
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6125,297,637 - 125,321,896 (+)Ensembl
GRCm38.p6 Ensembl6125,320,674 - 125,344,933 (+)Ensembl
RefSeq Acc Id: ENSMUST00000176365   ⟹   ENSMUSP00000135467
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6125,298,168 - 125,307,936 (+)Ensembl
GRCm38.p6 Ensembl6125,321,205 - 125,330,973 (+)Ensembl
RefSeq Acc Id: ENSMUST00000176442   ⟹   ENSMUSP00000135336
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6125,298,374 - 125,321,042 (+)Ensembl
GRCm38.p6 Ensembl6125,321,411 - 125,344,079 (+)Ensembl
RefSeq Acc Id: ENSMUST00000176655   ⟹   ENSMUSP00000135798
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6125,297,622 - 125,321,802 (+)Ensembl
GRCm38.p6 Ensembl6125,320,659 - 125,344,839 (+)Ensembl
RefSeq Acc Id: ENSMUST00000177329   ⟹   ENSMUSP00000134929
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6125,298,484 - 125,321,575 (+)Ensembl
GRCm38.p6 Ensembl6125,321,521 - 125,344,612 (+)Ensembl
RefSeq Acc Id: NM_001406028   ⟹   NP_001392957
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396125,290,575 - 125,321,906 (+)NCBI
RefSeq Acc Id: NM_001406031   ⟹   NP_001392960
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396125,286,657 - 125,321,906 (+)NCBI
RefSeq Acc Id: NM_011324   ⟹   NP_035454
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396125,298,303 - 125,321,906 (+)NCBI
GRCm386125,321,340 - 125,344,943 (+)NCBI
MGSCv376125,271,358 - 125,294,961 (+)RGD
Celera6126,992,384 - 127,015,966 (+)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017321471   ⟹   XP_017176960
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396125,297,593 - 125,321,906 (+)NCBI
GRCm386125,319,475 - 125,344,943 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030255276   ⟹   XP_030111136
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396125,290,978 - 125,321,906 (+)NCBI
GRCm386125,314,271 - 125,344,943 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036165971   ⟹   XP_036021864
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396125,299,849 - 125,321,906 (+)NCBI
Sequence:
RefSeq Acc Id: NP_035454   ⟸   NM_011324
- Peptide Label: isoform 1
- UniProtKB: Q61180 (UniProtKB/Swiss-Prot),   Q9WU37 (UniProtKB/Swiss-Prot),   Q3USG4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017176960   ⟸   XM_017321471
- Peptide Label: isoform X1
- UniProtKB: H3BLI2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030111136   ⟸   XM_030255276
- Peptide Label: isoform X2
- UniProtKB: Q80YC1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000134929   ⟸   ENSMUST00000177329
RefSeq Acc Id: ENSMUSP00000080164   ⟸   ENSMUST00000081440
RefSeq Acc Id: ENSMUSP00000135467   ⟸   ENSMUST00000176365
RefSeq Acc Id: ENSMUSP00000135336   ⟸   ENSMUST00000176442
RefSeq Acc Id: ENSMUSP00000135798   ⟸   ENSMUST00000176655
RefSeq Acc Id: ENSMUSP00000134940   ⟸   ENSMUST00000176110
RefSeq Acc Id: ENSMUSP00000135551   ⟸   ENSMUST00000175966
RefSeq Acc Id: XP_036021864   ⟸   XM_036165971
- Peptide Label: isoform X2
- UniProtKB: Q80YC1 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001392960   ⟸   NM_001406031
- Peptide Label: isoform 2
- UniProtKB: Q80YC1 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001392957   ⟸   NM_001406028
- Peptide Label: isoform 2
- UniProtKB: Q80YC1 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61180-F1-model_v2 AlphaFold Q61180 1-699 view protein structure

Promoters
RGD ID:6839960
Promoter ID:MM_KWN:47642
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung
Transcripts:NM_011324_SCNN1A,   UC009DUK.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366125,271,121 - 125,271,621 (+)MPROMDB
RGD ID:6891062
Promoter ID:EPDNEW_M8982
Type:initiation region
Name:Scnn1a_1
Description:Mus musculus sodium channel, nonvoltage-gated 1 alpha , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386125,321,351 - 125,321,411EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:101782 AgrOrtholog
Ensembl Genes ENSMUSG00000030340 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000081440 ENTREZGENE
  ENSMUST00000081440.14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSMUST00000175966.8 UniProtKB/TrEMBL
  ENSMUST00000176110.8 UniProtKB/TrEMBL
  ENSMUST00000176365.2 UniProtKB/TrEMBL
  ENSMUST00000176442.8 UniProtKB/TrEMBL
  ENSMUST00000176655.8 UniProtKB/TrEMBL
  ENSMUST00000177329.2 UniProtKB/TrEMBL
Gene3D-CATH Acid-sensing ion channels like domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  YojJ-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ENaC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENaC_chordates UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENaC_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20276 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:101782 ENTREZGENE
NCBI Gene 20276 ENTREZGENE
PANTHER AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11690 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ASC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB SCNN1A RGD
PhenoGen Scnn1a PhenoGen
PRINTS AMINACHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt H3BJC3_MOUSE UniProtKB/TrEMBL
  H3BKC4_MOUSE UniProtKB/TrEMBL
  H3BKP2_MOUSE UniProtKB/TrEMBL
  H3BKW1_MOUSE UniProtKB/TrEMBL
  H3BLI2 ENTREZGENE, UniProtKB/TrEMBL
  Q3USG4 ENTREZGENE, UniProtKB/TrEMBL
  Q61180 ENTREZGENE
  Q80YC1 ENTREZGENE, UniProtKB/TrEMBL
  Q924B6_MOUSE UniProtKB/TrEMBL
  Q99PN8_MOUSE UniProtKB/TrEMBL
  Q9WU37 ENTREZGENE
  SCNNA_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q9WU37 UniProtKB/Swiss-Prot