Rb1 (RB transcriptional corepressor 1) - Rat Genome Database

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Gene: Rb1 (RB transcriptional corepressor 1) Mus musculus
Symbol: Rb1
Name: RB transcriptional corepressor 1
RGD ID: 11219
Description: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and enzyme binding activity. Involved in several processes, including negative regulation of cold-induced thermogenesis; negative regulation of myofibroblast differentiation; and positive regulation of collagen fibril organization. Acts upstream of or within several processes, including negative regulation of cell population proliferation; neuron development; and regulation of transcription by RNA polymerase II. Located in nucleus and spindle. Part of Rb-E2F complex. Is expressed in several structures, including alimentary system; central nervous system; eye; gonad; and hemolymphoid system. Used to study lung small cell carcinoma; osteosarcoma; retinoblastoma; and urinary bladder cancer. Human ortholog(s) of this gene implicated in several diseases, including high grade glioma (multiple); osteosarcoma; prostate cancer; retinoblastoma (multiple); and small cell carcinoma. Orthologous to human RB1 (RB transcriptional corepressor 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: p; p110-RB1; pp105; pRb; R; Rb; Rb-; Rb-1; retinoblastoma 1; retinoblastoma-associated protein
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391473,430,298 - 73,563,446 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1473,421,113 - 73,563,262 (-)EnsemblGRCm39 Ensembl
GRCm381473,192,858 - 73,325,951 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1473,183,673 - 73,325,822 (-)EnsemblGRCm38mm10GRCm38
MGSCv371473,595,309 - 73,725,598 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361471,929,656 - 72,059,895 (-)NCBIMGSCv36mm8
Celera1470,715,843 - 70,870,859 (-)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1438.73NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Acute Erythroleukemia  (ISO)
acute kidney failure  (ISO)
acute lymphoblastic leukemia  (ISO)
Adrenal Gland Neoplasms  (ISO)
adrenocortical carcinoma  (ISO)
Animal Mammary Neoplasms  (IMP,ISO)
Autosomal Recessive Woolly Hair  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
B-lymphoblastic leukemia/lymphoma with ETV6-RUNX1  (ISO)
basal cell carcinoma  (ISO)
bone osteosarcoma  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiomegaly  (IDA)
cervix uteri carcinoma in situ  (ISO)
chromosome 13q14 deletion syndrome  (ISO)
disease of cellular proliferation  (ISO)
ductal carcinoma in situ  (ISO)
embryonal carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
familial retinoblastoma  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
glioblastoma proneural subtype  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hereditary nonpolyposis colorectal cancer type 4  (ISO)
hypotrichosis 8  (ISO)
in situ carcinoma  (ISO)
Insulin Resistance  (ISO)
intellectual disability  (ISO)
intestinal pseudo-obstruction  (IMP)
lung adenocarcinoma  (ISO)
lung non-small cell carcinoma  (ISO)
lung oat cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
medulloblastoma  (IGI,ISO)
mitochondrial DNA depletion syndrome 5  (ISO)
Neoplasm Metastasis  (ISO)
obesity  (ISO)
oligodendroglioma  (ISO)
osteosarcoma  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (IAGP,ISO)
pancreatic cancer  (ISO)
Phyllodes Tumor  (ISO)
Pituitary Neoplasms  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
renal cell carcinoma  (ISO)
retinoblastoma  (ISO)
seminoma  (ISO)
Sezary's disease  (ISO)
small cell carcinoma  (ISO)
squamous cell carcinoma  (ISO)
Stevens-Johnson syndrome  (ISO)
trilateral retinoblastoma  (ISO)
urinary bladder cancer  (ISO)
Urinary Bladder Neoplasm  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-colchicine  (EXP)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
(Z)-3-butylidenephthalide  (ISO)
1,2-dimethylhydrazine  (EXP)
1,3-thiazolidine-2,4-dione  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-butoxyethanol  (EXP)
2-cyclopenten-1-one  (ISO)
2-methylcholine  (ISO)
2-nitrofluorene  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-aminobenzamide  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-nitropropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP,ISO)
5-nitroso-8-quinolinol  (ISO)
6-O-methylguanine  (ISO)
6-oxocampestanol  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
9-cis-retinoic acid  (ISO)
acetylsalicylic acid  (ISO)
aconitine  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
Actein  (ISO)
acteoside  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
albuterol  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-hexachlorocyclohexane  (ISO)
alpha-naphthoflavone  (ISO)
alpha-pinene  (ISO)
alvocidib  (ISO)
amlodipine  (ISO)
ammonium chloride  (ISO)
amodiaquine  (ISO)
andrographolide  (ISO)
aniline  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arotinoid acid  (ISO)
arsenic trichloride  (EXP)
arsenous acid  (ISO)
Aspidin  (ISO)
atorvastatin calcium  (ISO)
auranofin  (ISO)
baicalein  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
benzophenanthridine  (ISO)
beta-naphthoflavone  (ISO)
betulinic acid  (ISO)
bexarotene  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
BMS-754807  (ISO)
bortezomib  (ISO)
brassinolide  (ISO)
bucladesine  (ISO)
buspirone  (ISO)
busulfan  (EXP)
butyric acid  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
calciol  (ISO)
calcitriol  (ISO)
calix[6]arene  (ISO)
calmidazolium  (ISO)
calyculin a  (ISO)
camptothecin  (EXP,ISO)
canertinib  (EXP)
capecitabine  (ISO)
captan  (EXP)
carbamazepine  (ISO)
cefaloridine  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
Chloramine  (ISO)
chlordecone  (EXP)
chlorohydrocarbon  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
clofibric acid  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (EXP)
coumarin  (ISO)
crocidolite asbestos  (EXP,ISO)
cudraflavone B  (ISO)
cumene  (EXP)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
D-glucose  (ISO)
dactolisib  (ISO)
daunorubicin  (ISO)
deguelin  (ISO)
dehydroepiandrosterone  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
Diacetoxyscirpenol  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dicoumarol  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (EXP,ISO)
dioxygen  (EXP)
doxazosin  (ISO)
doxorubicin  (ISO)
ellagic acid  (ISO)
emodin  (ISO)
endosulfan  (ISO)
erlotinib hydrochloride  (EXP,ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ethyl trans-caffeate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
everolimus  (ISO)
farrerol  (ISO)
fenhexamid  (ISO)
ferulic acid  (ISO)
flavanone  (ISO)
flavonoids  (ISO)
fluorometholone  (ISO)
flutamide  (ISO)
fluvastatin  (ISO)
folic acid  (EXP)
folpet  (EXP)
FR900359  (ISO)
fucoidan  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gadolinium trichloride  (ISO)
galangin  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gamma-tocopherol  (ISO)
gefitinib  (ISO)
genistein  (ISO)
gentamycin  (ISO)
gingerol  (ISO)
glafenine  (ISO)
glucose  (ISO)
glutathione  (ISO)
GW 4064  (ISO)
heparin  (ISO)
heptachlor  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxyurea  (EXP)
Hypsiziprenol-A9  (ISO)
ibuprofen  (ISO)
ICI 118551  (ISO)
indirubin  (EXP,ISO)
indoles  (ISO)
indometacin  (ISO)
inulin  (EXP)
irinotecan  (ISO)
isocyanates  (EXP)
isoeugenol  (ISO)
ivermectin  (ISO)
ketamine  (ISO)
KN-93  (ISO)
L-cysteine  (ISO)
lapatinib  (ISO)
lead nitrate  (ISO)
lead(0)  (ISO)
letrozole  (ISO)
levamisole  (ISO)
linsidomine  (EXP)
lipopolysaccharide  (EXP)
lithium chloride  (EXP,ISO)
lonafarnib  (EXP)
lopinavir  (ISO)
lovastatin  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
Lysocellin  (ISO)
magnesium atom  (ISO)
maneb  (ISO)
masoprocol  (ISO)
Maxacalcitol  (ISO)
menadione  (ISO)
menaquinone  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP,ISO)
methoxsalen  (ISO)
methoxyacetic acid  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
miconazole  (EXP)
mifepristone  (ISO)
mitomycin C  (ISO)
monosodium L-glutamate  (ISO)
motexafin gadolinium  (ISO)
myo-inositol hexakisphosphate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
nefazodone  (ISO)
nelfinavir  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (EXP,ISO)
nimesulide  (ISO)
nitrogen dioxide  (EXP)
Nonylphenol  (ISO)
O-(chloroacetylcarbamoyl)fumagillol  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
olomoucine  (ISO)
orlistat  (ISO)
oxaliplatin  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
palbociclib  (EXP,ISO)
panaxydol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (ISO)
pentobarbital  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosalone  (ISO)
picoxystrobin  (ISO)
pinosylvin  (ISO)
pioglitazone  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
prednisone  (ISO)
proanthocyanidin  (ISO)
procyanidin  (ISO)
progesterone  (EXP)
promethazine  (ISO)
pterostilbene  (ISO)
PX-866  (ISO)
quercetin  (ISO)
radicicol  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
ritonavir  (ISO)
Ro 41-5253  (ISO)
romidepsin  (ISO)
rottlerin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
SB 203580  (ISO)
silibinin  (EXP)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sirtinol  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sorafenib  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
sulindac  (ISO)
sulindac sulfide  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP,ISO)
tanespimycin  (ISO)
Tanshinone I  (EXP)
tauroursodeoxycholic acid  (ISO)
tazarotene  (ISO)
temozolomide  (ISO)
Temsirolimus  (ISO)
terephthalic acid  (ISO)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
theophylline  (ISO)
thioacetamide  (ISO)
thiophenes  (ISO)
tocopherol  (ISO)
tolbutamide  (ISO)
toluene  (ISO)
toxaphene  (ISO)
trametinib  (ISO)
trans-isoeugenol  (ISO)
trans-pinosylvin  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (EXP,ISO)
tunicamycin  (EXP)
tyrphostin AG 1478  (ISO)
urethane  (EXP)
ursodeoxycholic acid  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vinyl carbamate  (EXP)
vorinostat  (ISO)
wortmannin  (EXP,ISO)
Y-27632  (ISO)
zebularine  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aortic valve morphogenesis  (IMP)
apoptotic process  (IMP)
cell differentiation  (IBA)
cell division  (IMP)
cell morphogenesis involved in neuron differentiation  (IBA,IMP)
cell population proliferation  (IMP)
cellular response to insulin stimulus  (IDA)
cellular response to xenobiotic stimulus  (IMP)
chondrocyte differentiation  (IDA)
chromatin organization  (IEA)
chromosome organization  (ISO)
digestive tract development  (IMP)
enucleate erythrocyte differentiation  (IGI)
epithelial cell proliferation  (IMP)
G1/S transition of mitotic cell cycle  (IMP)
glial cell apoptotic process  (IMP)
glial cell proliferation  (IGI)
hepatocyte apoptotic process  (IMP)
heterochromatin formation  (ISO)
maintenance of mitotic sister chromatid cohesion  (ISO)
myoblast differentiation  (ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of cell cycle  (IMP,ISO)
negative regulation of cell growth  (IDA)
negative regulation of cell population proliferation  (IMP)
negative regulation of cold-induced thermogenesis  (IMP)
negative regulation of DNA-templated transcription  (IDA,ISO)
negative regulation of epithelial cell proliferation  (IMP)
negative regulation of G1/S transition of mitotic cell cycle  (IBA,IMP)
negative regulation of gene expression  (IMP,ISO)
negative regulation of glial cell proliferation  (IGI)
negative regulation of hepatocyte apoptotic process  (ISO)
negative regulation of inflammatory response  (IMP)
negative regulation of mitotic cell cycle  (IGI)
negative regulation of myofibroblast differentiation  (IMP)
negative regulation of smoothened signaling pathway  (IMP)
negative regulation of transcription by RNA polymerase II  (IDA,IGI)
neuron apoptotic process  (IMP)
neuron differentiation  (IMP)
neuron maturation  (IMP)
neuron projection development  (IBA,IMP)
positive regulation of collagen fibril organization  (IMP)
positive regulation of extracellular matrix organization  (IMP)
positive regulation of macrophage differentiation  (IGI)
positive regulation of mitotic metaphase/anaphase transition  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,IMP)
protein localization to chromosome, centromeric region  (ISO)
Ras protein signal transduction  (ISO)
regulation of cell cycle  (IMP)
regulation of cell growth  (IGI)
regulation of DNA-templated transcription  (ISO)
regulation of G1/S transition of mitotic cell cycle  (IGI)
regulation of mitotic cell cycle  (IMP,ISO)
regulation of transcription by RNA polymerase II  (IEA)
sister chromatid biorientation  (ISO)
skeletal muscle cell differentiation  (IGI,IMP)
smoothened signaling pathway  (IMP)
spermatogenesis  (ISO)
striated muscle cell differentiation  (IGI)
tissue homeostasis  (IGI)
transcription by RNA polymerase II  (IGI)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal amacrine cell morphology  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal brain interneuron morphology  (IAGP)
abnormal brain morphology  (IAGP)
abnormal bronchiole morphology  (IAGP)
abnormal cartilage morphology  (IAGP)
abnormal cell cycle  (IAGP)
abnormal cell cycle checkpoint function  (IAGP)
abnormal cell differentiation  (IAGP)
abnormal cell proliferation  (IAGP)
abnormal cerebellar cortex morphology  (IAGP)
abnormal cerebellar granule cell morphology  (IAGP)
abnormal cerebellar granule layer morphology  (IAGP)
abnormal cerebellum external granule cell layer morphology  (IAGP)
abnormal cerebellum vermis morphology  (IAGP)
abnormal chromosome morphology  (IAGP)
abnormal cochlear hair cell morphology  (IAGP)
abnormal cochlear outer hair cell morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal deltoid tuberosity morphology  (IAGP)
abnormal DNA methylation  (IAGP)
abnormal dorsal root ganglion morphology  (IAGP)
abnormal embryo development  (IAGP)
abnormal enterocyte proliferation  (IAGP)
abnormal epidermis stratum granulosum morphology  (IAGP)
abnormal epidermis suprabasal layer morphology  (IAGP)
abnormal erythrocyte morphology  (IAGP)
abnormal erythropoiesis  (IAGP)
abnormal eye anterior chamber morphology  (IAGP)
abnormal eye morphology  (IAGP)
abnormal eye posterior chamber morphology  (IAGP)
abnormal fertility/fecundity  (IAGP)
abnormal fourth ventricle morphology  (IAGP)
abnormal frontal lobe morphology  (IAGP)
abnormal gait  (IAGP)
abnormal hearing physiology  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal imprinting  (IAGP)
abnormal lens development  (IAGP)
abnormal lens fiber morphology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal lung morphology  (IAGP)
abnormal macrophage differentiation  (IAGP)
abnormal macrophage morphology  (IAGP)
abnormal melanocyte morphology  (IAGP)
abnormal milk ejection  (IAGP)
abnormal mitosis  (IAGP)
abnormal muscle physiology  (IAGP)
abnormal myelopoiesis  (IAGP)
abnormal myocardial fiber physiology  (IAGP)
abnormal myogenesis  (IAGP)
abnormal neuroendocrine gland morphology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuronal precursor proliferation  (IAGP)
abnormal oral mucosa morphology  (IAGP)
abnormal organ of Corti morphology  (IAGP)
abnormal organ of Corti supporting cell proliferation  (IAGP)
abnormal perineum morphology  (IAGP)
abnormal pilomotor reflex  (IAGP)
abnormal pituitary intermediate lobe morphology  (IAGP)
abnormal placenta labyrinth morphology  (IAGP)
abnormal placental transport  (IAGP)
abnormal posture  (IAGP)
abnormal pulmonary neuroendocrine body morphology  (IAGP)
abnormal Purkinje cell morphology  (IAGP)
abnormal response/metabolism to endogenous compounds  (IAGP)
abnormal retina apoptosis  (IAGP)
abnormal retina ganglion layer morphology  (IAGP)
abnormal retina horizontal cell morphology  (IAGP)
abnormal retina inner nuclear layer morphology  (IAGP)
abnormal retina inner plexiform layer morphology  (IAGP)
abnormal retina morphology  (IAGP)
abnormal retina neuronal layer morphology  (IAGP)
abnormal retina photoreceptor morphology  (IAGP)
abnormal scapula morphology  (IAGP)
abnormal skeletal muscle fiber morphology  (IAGP)
abnormal skeletal muscle morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal spine curvature  (IAGP)
abnormal stationary movement  (IAGP)
abnormal sternocostal joint morphology  (IAGP)
abnormal sternum ossification  (IAGP)
abnormal third ventricle morphology  (IAGP)
abnormal thyroid gland morphology  (IAGP)
abnormal trigeminal ganglion morphology  (IAGP)
abnormal tumor morphology  (IAGP)
abnormal tumor pathology  (IAGP)
abnormal tumor vascular morphology  (IAGP)
abnormal utricular macula morphology  (IAGP)
abnormal vestibular hair cell morphology  (IAGP)
abnormal vestibular hair cell stereociliary bundle morphology  (IAGP)
abnormal vestibular system physiology  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
abnormal white adipose tissue morphology  (IAGP)
abnormal xiphoid process morphology  (IAGP)
absent deltoid tuberosity  (IAGP)
absent retina bipolar cells  (IAGP)
absent retina ganglion cell  (IAGP)
adrenal medulla hyperplasia  (IAGP)
anemia  (IAGP)
aneuploidy  (IAGP)
astrocytosis  (IAGP)
ataxia  (IAGP)
bronchial epithelial hyperplasia  (IAGP)
cachexia  (IAGP)
cataract  (IAGP)
cerebellum hypoplasia  (IAGP)
chromosomal instability  (IAGP)
circling  (IAGP)
cochlear hair cell degeneration  (IAGP)
cochlear outer hair cell degeneration  (IAGP)
deafness  (IAGP)
decreased apoptosis  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased brain size  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased embryo size  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased fetal size  (IAGP)
decreased heart rate  (IAGP)
decreased hepatocyte number  (IAGP)
decreased length of long bones  (IAGP)
decreased osteosarcoma incidence  (IAGP)
decreased retina apoptosis  (IAGP)
decreased retina cone cell number  (IAGP)
decreased retina ganglion cell number  (IAGP)
decreased retina photoreceptor cell number  (IAGP)
decreased retina rod cell number  (IAGP)
decreased skeletal muscle fiber density  (IAGP)
decreased skeletal muscle mass  (IAGP)
decreased susceptibility to induced morbidity/mortality  (IAGP)
decreased T cell proliferation  (IAGP)
decreased testis weight  (IAGP)
decreased tumor growth/size  (IAGP)
decreased tumor incidence  (IAGP)
decreased tumor latency  (IAGP)
decreased tumor-free survival time  (IAGP)
decreased ventricle muscle contractility  (IAGP)
dilated fourth ventricle  (IAGP)
dilated heart left ventricle  (IAGP)
dilated liver sinusoidal space  (IAGP)
disorganized retina inner nuclear layer  (IAGP)
distended abdomen  (IAGP)
ectopic Purkinje cell  (IAGP)
edema  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged fourth ventricle  (IAGP)
enlarged heart  (IAGP)
epidermal hyperplasia  (IAGP)
flat forehead  (IAGP)
fragile skeleton  (IAGP)
gliosis  (IAGP)
hematuria  (IAGP)
hemorrhage  (IAGP)
hunched posture  (IAGP)
hyporesponsive to tactile stimuli  (IAGP)
hypoxia  (IAGP)
impaired balance  (IAGP)
impaired swimming  (IAGP)
increased adrenal gland tumor incidence  (IAGP)
increased apoptosis  (IAGP)
increased body mass index  (IAGP)
increased brain size  (IAGP)
increased brain tumor incidence  (IAGP)
increased brain weight  (IAGP)
increased carcinoma incidence  (IAGP)
increased cell migration  (IAGP)
increased cell proliferation  (IAGP)
increased circulating alkaline phosphatase level  (IAGP)
increased circulating glucagon level  (IAGP)
increased cochlear hair cell number  (IAGP)
increased cochlear inner hair cell number  (IAGP)
increased cochlear outer hair cell number  (IAGP)
increased colon adenoma incidence  (IAGP)
increased Deiters cell number  (IAGP)
increased fibroblast proliferation  (IAGP)
increased gastrointestinal tumor incidence  (IAGP)
increased glioma incidence  (IAGP)
increased glucagonoma incidence  (IAGP)
increased hemangioma incidence  (IAGP)
increased hepatocellular carcinoma incidence  (IAGP)
increased hibernoma incidence  (IAGP)
increased intestinal adenocarcinoma incidence  (IAGP)
increased leiomyosarcoma incidence  (IAGP)
increased lens fiber apoptosis  (IAGP)
increased liver tumor incidence  (IAGP)
increased lung adenocarcinoma incidence  (IAGP)
increased lung carcinoma incidence  (IAGP)
increased lung small cell carcinoma incidence  (IAGP)
increased lung tumor incidence  (IAGP)
increased lymphoblastic lymphoma incidence  (IAGP)
increased lymphoma incidence  (IAGP)
increased mammary gland tumor incidence  (IAGP)
increased medulloblastoma incidence  (IAGP)
increased megakaryocyte cell number  (IAGP)
increased metastatic potential  (IAGP)
increased mitotic index  (IAGP)
increased myocardial fiber size  (IAGP)
increased nervous system tumor incidence  (IAGP)
increased neuroblastoma incidence  (IAGP)
increased neuron apoptosis  (IAGP)
increased neuronal precursor cell number  (IAGP)
increased nucleated erythrocyte cell number  (IAGP)
increased organ of Corti supporting cell number  (IAGP)
increased osteosarcoma incidence  (IAGP)
increased ovarian carcinoma incidence  (IAGP)
increased ovary tumor incidence  (IAGP)
increased pancreas tumor incidence  (IAGP)
increased pancreatic islet cell carcinoma incidence  (IAGP)
increased papilloma incidence  (IAGP)
increased parathyroid gland tumor incidence  (IAGP)
increased pheochromocytoma incidence  (IAGP)
increased pituitary adenohypophysis tumor incidence  (IAGP)
increased pituitary adenoma incidence  (IAGP)
increased pituitary gland tumor incidence  (IAGP)
increased pituitary melanotroph tumor incidence  (IAGP)
increased prostate gland tumor incidence  (IAGP)
increased prostate intraepithelial neoplasia incidence  (IAGP)
increased retina apoptosis  (IAGP)
increased retinoblastoma incidence  (IAGP)
increased sarcoma incidence  (IAGP)
increased skin tumor incidence  (IAGP)
increased squamous cell carcinoma incidence  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased susceptibility to infection  (IAGP)
increased teratoma incidence  (IAGP)
increased testicular teratoma incidence  (IAGP)
increased thyroid adenoma incidence  (IAGP)
increased thyroid C-cell carcinoma incidence  (IAGP)
increased thyroid carcinoma incidence  (IAGP)
increased thyroid tumor incidence  (IAGP)
increased tumor growth/size  (IAGP)
increased tumor incidence  (IAGP)
increased tumor latency  (IAGP)
increased tumor-free survival time  (IAGP)
increased urinary bladder carcinoma incidence  (IAGP)
increased vestibular hair cell number  (IAGP)
intestinal ulcer  (IAGP)
kyphosis  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethargy  (IAGP)
liver hypoplasia  (IAGP)
low mean erythrocyte cell number  (IAGP)
male infertility  (IAGP)
mammary gland duct hyperplasia  (IAGP)
mammary gland hyperplasia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
neurodegeneration  (IAGP)
no abnormal phenotype detected  (IAGP)
obese  (IAGP)
pale yolk sac  (IAGP)
pallor  (IAGP)
pericardial edema  (IAGP)
perinatal lethality  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
pituitary intermediate lobe hyperplasia  (IAGP)
polyploidy  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preneoplasia  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
respiratory distress  (IAGP)
retina hypoplasia  (IAGP)
skeletal muscle atrophy  (IAGP)
skin edema  (IAGP)
small dorsal root ganglion  (IAGP)
small liver  (IAGP)
small testis  (IAGP)
thin cerebellar granule layer  (IAGP)
thin cerebellar molecular layer  (IAGP)
thin external granule cell layer  (IAGP)
thin retina inner nuclear layer  (IAGP)
thin retina inner plexiform layer  (IAGP)
thin retina outer nuclear layer  (IAGP)
thymus hypoplasia  (IAGP)
transmission ratio distortion  (IAGP)
tremors  (IAGP)
uterine hemorrhage  (IAGP)
vagina atresia  (IAGP)
vestibular hair cell degeneration  (IAGP)
weight loss  (IAGP)

References - curated
# Reference Title Reference Citation
1. A cyclin D2-Rb pathway regulates cardiac myocyte size and RNA polymerase III after biomechanical stress in adult myocardium. Angelis E, etal., Circ Res. 2008 May 23;102(10):1222-9. doi: 10.1161/CIRCRESAHA.107.163550. Epub 2008 Apr 17.
2. Deregulation of the RB pathway in human testicular germ cell tumours. Bartkova J, etal., J Pathol. 2003 Jun;200(2):149-56.
3. Chromosomal imbalances, loss of heterozygosity, and immunohistochemical expression of TP53, RB1, and PTEN in intraductal cancer, intraepithelial neoplasia, and invasive adenocarcinoma of the prostate. Bettendorf O, etal., Genes Chromosomes Cancer. 2008 Jul;47(7):565-72.
4. Loss of heterozygosity at 13q14 correlates with RB1 gene underexpression in human breast cancer. Bieche I and Lidereau R, Mol Carcinog. 2000 Nov;29(3):151-8.
5. Mutations in Rb1 pathway-related genes are associated with poor prognosis in anaplastic astrocytomas. B├Ącklund LM, etal., Br J Cancer. 2005 Jul 11;93(1):124-30. doi: 10.10