Pthlh (parathyroid hormone-like peptide) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Pthlh (parathyroid hormone-like peptide) Mus musculus
Analyze
Symbol: Pthlh
Name: parathyroid hormone-like peptide
RGD ID: 11188
MGI Page MGI
Description: Predicted to enable hormone activity and peptide hormone receptor binding activity. Acts upstream of or within several processes, including endochondral ossification; lung development; and mammary gland morphogenesis. Located in nucleus. Is expressed in several structures, including brain; female reproductive system; integumental system; limb; and skeleton. Used to study Albright's hereditary osteodystrophy and achondroplasia. Human ortholog(s) of this gene implicated in brachydactyly type E2. Orthologous to human PTHLH (parathyroid hormone like hormone).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: parathyroid hormone-like hormone; parathyroid hormone-like protein; parathyroid hormone-related peptide; parathyroid hormone-related protein; PLP; Pt; PTH-l; PTH-like; PTH-related peptide; PTH-rP; Pthrp
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396147,153,607 - 147,165,511 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6147,153,599 - 147,165,681 (-)EnsemblGRCm39 Ensembl
GRCm386147,252,109 - 147,264,013 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6147,252,101 - 147,264,183 (-)EnsemblGRCm38mm10GRCm38
MGSCv376147,200,632 - 147,212,607 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366147,209,270 - 147,221,371 (-)NCBIMGSCv36mm8
Celera6150,289,180 - 150,301,102 (-)NCBICelera
Cytogenetic Map6G3NCBI
cM Map678.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(E)-thiamethoxam  (EXP)
1,2-dimethylhydrazine  (EXP)
1-nitropyrene  (ISO)
1-Oleoyl-2-acetyl-sn-glycerol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-nitroquinoline N-oxide  (EXP)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
amitrole  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
betulinic acid  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bortezomib  (ISO)
butan-1-ol  (ISO)
butane-2,3-dione  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
calcium carbonate  (ISO)
candesartan  (ISO)
ceruletide  (EXP,ISO)
CGP 52608  (ISO)
chloroethene  (EXP)
chloropicrin  (ISO)
chloroprene  (EXP)
cisplatin  (ISO)
cobalt atom  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
enalapril  (ISO)
ethanol  (EXP,ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
geldanamycin  (ISO)
gentamycin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
losartan  (ISO)
manganese(II) chloride  (ISO)
mercury dichloride  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
N-Nitrosopyrrolidine  (ISO)
nitrofen  (ISO)
O-methyleugenol  (ISO)
ozone  (ISO)
paracetamol  (ISO)
pentane-2,3-dione  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
quinapril hydrochloride  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (ISO)
Soman  (ISO)
styrene  (EXP)
sulfadimethoxine  (ISO)
tamoxifen  (ISO)
telmisartan  (ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
thiamethoxam  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
trichostatin A  (ISO)
undecane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal ameloblast morphology  (IAGP)
abnormal angiogenesis  (IAGP)
abnormal appendicular skeleton morphology  (IAGP)
abnormal autophagy  (IAGP)
abnormal axial skeleton morphology  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal bone marrow development  (IAGP)
abnormal bone mineralization  (IAGP)
abnormal bone ossification  (IAGP)
abnormal bone structure  (IAGP)
abnormal bone trabecula morphology  (IAGP)
abnormal brain vasculature morphology  (IEA)
abnormal calcium ion homeostasis  (IAGP)
abnormal cartilage development  (IAGP)
abnormal cervical rib  (IEA)
abnormal chondrocyte differentiation  (IAGP)
abnormal circulating calcium level  (IAGP)
abnormal circulating hormone level  (IAGP)
abnormal clavicle morphology  (IAGP)
abnormal cranium morphology  (IEA)
abnormal ductus venosus valve morphology  (IEA)
abnormal enamel morphology  (IAGP)
abnormal forebrain morphology  (IEA)
abnormal gait  (IAGP)
abnormal head morphology  (IEA)
abnormal inferior vena cava morphology  (IEA)
abnormal long bone epiphyseal plate morphology  (IAGP)
abnormal long bone epiphyseal plate proliferative zone  (IAGP)
abnormal long bone hypertrophic chondrocyte zone  (IAGP)
abnormal long bone metaphysis morphology  (IAGP)
abnormal long bone morphology  (IAGP)
abnormal lung development  (IAGP)
abnormal lung interstitium morphology  (IAGP)
abnormal lung morphology  (IAGP)
abnormal lung saccule morphology  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal mesenchymal cell differentiation involved in lung development  (IAGP)
abnormal molar morphology  (IAGP)
abnormal neurocranium morphology  (IAGP)
abnormal odontoblast morphology  (IAGP)
abnormal osteoblast differentiation  (IAGP)
abnormal osteoblast morphology  (IAGP)
abnormal osteoclast morphology  (IAGP)
abnormal postnatal growth  (IAGP)
abnormal pulmonary alveolus epithelium morphology  (IAGP)
abnormal rib morphology  (IAGP)
abnormal skeleton development  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal sternum ossification  (IAGP)
abnormal thoracic cage shape  (IAGP)
abnormal tooth development  (IAGP)
abnormal tooth morphology  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal type II pneumocyte morphology  (IAGP)
abnormal urine homeostasis  (IAGP)
abnormal vertebral body morphology  (IAGP)
abnormal vitamin D level  (IAGP)
absent tooth root  (IAGP)
absent type I pneumocytes  (IAGP)
atelectasis  (IAGP)
cachexia  (IAGP)
chondrodystrophy  (IAGP)
cyanosis  (IAGP)
decreased alveolar lamellar body number  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IAGP)
decreased brain size  (IAGP)
decreased cell proliferation  (IAGP)
decreased chondrocyte number  (IAGP)
decreased chondrocyte proliferation  (IAGP)
decreased circulating glucose level  (IAGP)
decreased length of long bones  (IAGP)
decreased long bone epiphyseal plate size  (IAGP)
decreased osteoblast cell number  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased surfactant secretion  (IAGP)
decreased total body fat amount  (IAGP)
dilated liver sinusoidal space  (IEA)
disorganized long bone epiphyseal plate  (IAGP)
disproportionate dwarf  (IAGP)
distended abdomen  (IAGP)
domed cranium  (IAGP)
embryo tumor  (IEA)
enlarged parathyroid gland  (IAGP)
exophthalmos  (IAGP)
failure of tooth eruption  (IAGP)
flattened snout  (IAGP)
frontal bossing  (IAGP)
hyperkeratosis  (IAGP)
increased apoptosis  (IAGP)
increased blood urea nitrogen level  (IEA)
increased bone mass  (IAGP)
increased chondrocyte apoptosis  (IAGP)
increased compact bone thickness  (IAGP)
increased diameter of long bones  (IAGP)
increased osteoblast apoptosis  (IAGP)
increased osteoblast cell number  (IAGP)
increased osteocyte apoptosis  (IAGP)
increased width of hypertrophic chondrocyte zone  (IAGP)
kyphosis  (IAGP)
long lower incisors  (IAGP)
long tibia  (IAGP)
malocclusion  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IEA)
osteoporosis  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature aging  (IAGP)
premature bone ossification  (IAGP)
premature death  (IAGP)
premature endochondral bone ossification  (IAGP)
preweaning lethality, complete penetrance  (IEA)
protruding tongue  (IAGP)
respiratory failure  (IAGP)
shallow orbits  (IAGP)
short femur  (IAGP)
short humerus  (IAGP)
short limbs  (IAGP)
short mandible  (IAGP)
short maxilla  (IAGP)
short radius  (IAGP)
short ribs  (IAGP)
short snout  (IAGP)
short sternum  (IAGP)
short tibia  (IAGP)
short ulna  (IAGP)
small lung  (IAGP)
small lung saccule  (IAGP)
small thoracic cavity  (IAGP)
splayed ribs  (IAGP)
thick lung-associated mesenchyme  (IAGP)
thin epidermis  (IAGP)
tooth ankylosis  (IAGP)
tooth impaction  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. TGFbeta2 mediates the effects of hedgehog on hypertrophic differentiation and PTHrP expression. Alvarez J, etal., Development. 2002 Apr;129(8):1913-24.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Rat parathyroid hormone-like peptide: comparison with the human homologue and expression in malignant and normal tissue. Yasuda T, etal., Mol Endocrinol 1989 Mar;3(3):518-25.
Additional References at PubMed
PMID:1354597   PMID:1628813   PMID:1889815   PMID:1973379   PMID:2055117   PMID:2249778   PMID:7508121   PMID:7516868   PMID:7590978   PMID:8056147   PMID:8089190   PMID:8185578  
PMID:8314082   PMID:8557651   PMID:8592727   PMID:8608863   PMID:8662546   PMID:8662561   PMID:8816783   PMID:8840192   PMID:8889548   PMID:8895385   PMID:8938591   PMID:8986793  
PMID:9008714   PMID:9391087   PMID:9460531   PMID:9477327   PMID:9664687   PMID:9736773   PMID:9751753   PMID:9789035   PMID:9806774   PMID:9832460   PMID:9856827   PMID:9858490  
PMID:9921650   PMID:10049363   PMID:10098520   PMID:10098521   PMID:10213384   PMID:10330406   PMID:10330492   PMID:10409496   PMID:10409817   PMID:10449432   PMID:10465785   PMID:10530918  
PMID:10631175   PMID:10639544   PMID:10742104   PMID:10843788   PMID:10854780   PMID:10922068   PMID:11103933   PMID:11156472   PMID:11161799   PMID:11171335   PMID:11171337   PMID:11306604  
PMID:11316774   PMID:11498728   PMID:11518254   PMID:11566859   PMID:11606467   PMID:11702786   PMID:11714677   PMID:11748145   PMID:11760831   PMID:11792564   PMID:11832378   PMID:11879796  
PMID:11897779   PMID:11994406   PMID:12049768   PMID:12050144   PMID:12135917   PMID:12185361   PMID:12194850   PMID:12351440   PMID:12379497   PMID:12399319   PMID:12414734   PMID:12466851  
PMID:12477932   PMID:12538525   PMID:12606286   PMID:12671051   PMID:12713572   PMID:12810618   PMID:12960089   PMID:14586397   PMID:14597768   PMID:14668414   PMID:14694163   PMID:14722611  
PMID:14745966   PMID:14751559   PMID:14966569   PMID:14980515   PMID:14993235   PMID:15039145   PMID:15124025   PMID:15132997   PMID:15162506   PMID:15177029   PMID:15226640   PMID:15355563  
PMID:15489334   PMID:15542035   PMID:15561942   PMID:15741244   PMID:15841179   PMID:15866164   PMID:15883646   PMID:15901283   PMID:15923624   PMID:15951842   PMID:16138191   PMID:16141072  
PMID:16284117   PMID:16355280   PMID:16375886   PMID:16421188   PMID:16537572   PMID:16602821   PMID:16672315   PMID:16675960   PMID:16783635   PMID:16783882   PMID:16818445   PMID:16857753  
PMID:16877353   PMID:16935278   PMID:16988000   PMID:17003237   PMID:17065821   PMID:17083128   PMID:17166921   PMID:17191253   PMID:17199044   PMID:17200368   PMID:17301089   PMID:17328886  
PMID:17443683   PMID:17481601   PMID:17576802   PMID:17660199   PMID:17670790   PMID:17997355   PMID:18025304   PMID:18052755   PMID:18183793   PMID:18247361   PMID:18258656   PMID:18358824  
PMID:18434416   PMID:18456591   PMID:18477451   PMID:18539921   PMID:18550647   PMID:18597638   PMID:18601749   PMID:18621740   PMID:18636074   PMID:18791844   PMID:19035497   PMID:19091948  
PMID:19147675   PMID:19196804   PMID:19224984   PMID:19252479   PMID:19351720   PMID:19378260   PMID:19389373   PMID:19389374   PMID:19419310   PMID:19474191   PMID:19487464   PMID:19557172  
PMID:19574446   PMID:19590577   PMID:19605502   PMID:19704004   PMID:19723659   PMID:19759178   PMID:19795511   PMID:19906842   PMID:19906844   PMID:19948490   PMID:19959711   PMID:19968565  
PMID:20032198   PMID:20145205   PMID:20170896   PMID:20200004   PMID:20428761   PMID:20530870   PMID:20534695   PMID:20675290   PMID:20876097   PMID:20920500   PMID:20951345   PMID:21308774  
PMID:21312270   PMID:21677750   PMID:21702022   PMID:21872610   PMID:21873635   PMID:21911092   PMID:22056386   PMID:22087279   PMID:22210745   PMID:22290230   PMID:22291434   PMID:22318950  
PMID:22451941   PMID:22808183   PMID:22844494   PMID:22930757   PMID:22967998   PMID:23026747   PMID:23034629   PMID:23109045   PMID:23284101   PMID:23364519   PMID:23494914   PMID:23545937  
PMID:23716486   PMID:23720345   PMID:23782944   PMID:23895994   PMID:23937065   PMID:23940373   PMID:24154525   PMID:24161523   PMID:24349082   PMID:24586192   PMID:24762197   PMID:24777663  
PMID:24785493   PMID:24862038   PMID:24930703   PMID:24936779   PMID:24952961   PMID:25035110   PMID:25043053   PMID:25057796   PMID:25107907   PMID:25187507   PMID:25340332   PMID:25529628  
PMID:25645361   PMID:25761772   PMID:25808752   PMID:25917430   PMID:26052897   PMID:26094741   PMID:26097038   PMID:26116392   PMID:26121068   PMID:26164475   PMID:26229008   PMID:26432258  
PMID:26495794   PMID:26518653   PMID:26581094   PMID:26794256   PMID:26859332   PMID:26859889   PMID:26952977   PMID:26992132   PMID:27018594   PMID:27068606   PMID:27075243   PMID:27335464  
PMID:27373231   PMID:27391423   PMID:27666725   PMID:27930311   PMID:28027321   PMID:28408247   PMID:28408643   PMID:28698625   PMID:28741471   PMID:28864069   PMID:28914969   PMID:29222391  
PMID:29353060   PMID:29805302   PMID:30401834   PMID:30509999   PMID:30843886   PMID:30973865   PMID:31201465   PMID:31430259   PMID:31927188   PMID:32973206   PMID:33095824   PMID:33492304  
PMID:33724469   PMID:33879790   PMID:34101894   PMID:34108685   PMID:34309509   PMID:34376651   PMID:35440032   PMID:35863746   PMID:35887221   PMID:35974052   PMID:37236490   PMID:37318953  
PMID:37440279   PMID:37568579   PMID:37683603   PMID:37704733   PMID:38051593   PMID:38058151   PMID:38234039   PMID:38346197   PMID:38355793   PMID:39090666  


Genomics

Comparative Map Data
Pthlh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396147,153,607 - 147,165,511 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6147,153,599 - 147,165,681 (-)EnsemblGRCm39 Ensembl
GRCm386147,252,109 - 147,264,013 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6147,252,101 - 147,264,183 (-)EnsemblGRCm38mm10GRCm38
MGSCv376147,200,632 - 147,212,607 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366147,209,270 - 147,221,371 (-)NCBIMGSCv36mm8
Celera6150,289,180 - 150,301,102 (-)NCBICelera
Cytogenetic Map6G3NCBI
cM Map678.19NCBI
PTHLH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381227,958,084 - 27,972,733 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1227,958,084 - 27,972,733 (-)EnsemblGRCh38hg38GRCh38
GRCh371228,111,017 - 28,125,666 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361228,002,284 - 28,016,183 (-)NCBINCBI36Build 36hg18NCBI36
Build 341228,002,283 - 28,014,161NCBI
Celera1233,256,594 - 33,270,557 (-)NCBICelera
Cytogenetic Map12p11.22NCBI
HuRef1227,880,337 - 27,894,279 (-)NCBIHuRef
CHM1_11228,076,045 - 28,089,944 (-)NCBICHM1_1
T2T-CHM13v2.01227,829,831 - 27,844,463 (-)NCBIT2T-CHM13v2.0
Pthlh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84181,919,400 - 181,930,454 (-)NCBIGRCr8
mRatBN7.24180,188,792 - 180,199,847 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4180,188,792 - 180,199,847 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4186,472,387 - 186,483,481 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04182,256,935 - 182,268,028 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04180,877,368 - 180,888,461 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04181,663,425 - 181,674,181 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04245,811,895 - 245,822,651 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44184,887,702 - 184,898,841 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14185,132,825 - 185,143,965 (-)NCBI
Celera4168,675,915 - 168,686,473 (-)NCBICelera
RH 3.4 Map41091.1RGD
Cytogenetic Map4q44NCBI
Pthlh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555056,834,533 - 6,847,335 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555056,834,533 - 6,846,909 (+)NCBIChiLan1.0ChiLan1.0
PTHLH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21068,846,032 - 68,858,167 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11268,842,410 - 68,854,564 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01258,341,361 - 58,355,804 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11260,959,327 - 60,973,749 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1260,960,071 - 60,973,750 (+)Ensemblpanpan1.1panPan2
PTHLH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12719,781,557 - 19,795,078 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2719,781,557 - 19,795,078 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2726,604,753 - 26,729,826 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02719,869,742 - 19,989,315 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2719,975,781 - 19,989,312 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12719,676,917 - 19,795,837 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02719,703,486 - 19,822,427 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02726,761,823 - 26,881,419 (-)NCBIUU_Cfam_GSD_1.0
Pthlh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494581,724,063 - 81,735,818 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936760197,525 - 209,518 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936760197,525 - 209,212 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTHLH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl545,751,292 - 45,763,415 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1545,750,968 - 45,763,421 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2549,159,951 - 49,172,393 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTHLH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11127,682,300 - 27,694,808 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1127,682,338 - 27,694,898 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660697,351,760 - 7,364,353 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pthlh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247788,008,056 - 8,019,612 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247788,007,358 - 8,019,538 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pthlh
30 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:111
Count of miRNA genes:109
Interacting mature miRNAs:109
Transcripts:ENSMUST00000052296
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142079Skmw15_mskeletal muscle weight 15 (mouse)Not determined6116829851149588044Mouse
10449437Pas15_mpulmonary adenoma susceptibility 15 (mouse)6128180868149588044Mouse
1301084Bpq5_mblood pressure QTL 5 (mouse)Not determined6129330484149588044Mouse
14746990Manh61_mmandible shape 61 (mouse)6130156355149588044Mouse
4141295Rua_mraffinose acetate tasting (mouse)Not determined115546805149549364Mouse
10766452Sle23_msystematic lupus erythematosus susceptibility 23 (mouse)6128601582149588044Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
14746999Mancz6_mmandible centroid size 6 (mouse)6130156355149588044Mouse
1302089Wta2_mweight adult 2 (mouse)Not determined6125269523149588044Mouse
1301686Trmq1_mT cell ratio modifier QTL 1 (mouse)Not determined6129330484149588044Mouse
1301620Insq8_minsulin QTL 8 (mouse)Not determined6129534979149588044Mouse
10053680Lith25_mlithogenic gene 25 (mouse)Not determined6128601582149588044Mouse
4141974Skmw14_mskeletal muscle weight 14 (mouse)Not determined6129330484149588044Mouse
15092047Wsigrme2_mweek six growth rate, maternal effect 2 (mouse)6140497205147252976Mouse
15092045Wngrme2_mweek nine growth rate, maternal effect 2 (mouse)6140497205147252976Mouse
1301027Hdlq12_mHDL QTL 12 (mouse)Not determined6128601582149588044Mouse
15092052Wsegrme2_mweek seven growth rate, maternal effect 2 (mouse)6140497205147252976Mouse
1301152Athsq2_matherosclerosis susceptibility QTL 2 (mouse)Not determined6117059949149588044Mouse
15092053Wegrme2_mweek eight growth rate, maternal effect 2 (mouse)6140445726147201498Mouse
1301927Etohcta6_methanol conditioned taste aversion 6 (mouse)Not determined6115578005149578150Mouse
4141194Cyx_mcycloheximide tasting (mouse)Not determined115546805149549364Mouse
1558959Eamcd2_mexperimental autoimmune myocarditis 2 (mouse)Not determined6129953954149588044Mouse
15092060Wfogrme1_mweek four growth rate, maternal effect 1 (mouse)6140497205147252976Mouse
15092061Wfigrme1_mweek five growth rate, maternal effect 1 (mouse)6140445726147201498Mouse
15092058Lgrme2_mlate growth rate, maternal effect 2 (mouse)6140497205147252976Mouse
4141889Qui_mquinine sensitivity, taste (mouse)Not determined115546805149549364Mouse
15092056Mgrme1_mmid growth rate, maternal effect 1 (mouse)6140497205147252976Mouse
1301804Bulb2_mbulb size 2 (mouse)Not determined6120416806149588044Mouse

Markers in Region
D6Mit26  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386147,264,666 - 147,264,871UniSTSGRCm38
MGSCv376147,213,188 - 147,213,393UniSTSGRCm37
Cytogenetic Map6F-GUniSTS
cM Map674.4UniSTS
Whitehead Genetic665.6UniSTS
Whitehead_YAC6 UniSTS
RH94501  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386147,252,204 - 147,252,403UniSTSGRCm38
MGSCv376147,200,726 - 147,200,925UniSTSGRCm37
Celera6150,289,274 - 150,289,473UniSTS
Cytogenetic Map6F-GUniSTS
PMC229353P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386147,263,736 - 147,263,826UniSTSGRCm38
MGSCv376147,212,258 - 147,212,348UniSTSGRCm37
Celera6150,300,753 - 150,300,843UniSTS
Cytogenetic Map6F-GUniSTS
Pthlh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6F-GUniSTS
cM Map674.0UniSTS
Pthlh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6F-GUniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000052296   ⟹   ENSMUSP00000051433
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6147,153,599 - 147,165,665 (-)Ensembl
GRCm38.p6 Ensembl6147,252,101 - 147,264,167 (-)Ensembl
Ensembl Acc Id: ENSMUST00000204197   ⟹   ENSMUSP00000145509
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6147,153,607 - 147,165,681 (-)Ensembl
GRCm38.p6 Ensembl6147,252,109 - 147,264,183 (-)Ensembl
RefSeq Acc Id: NM_008970   ⟹   NP_032996
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396147,153,607 - 147,165,511 (-)NCBI
GRCm386147,252,109 - 147,264,013 (-)NCBI
MGSCv376147,200,632 - 147,212,607 (-)RGD
Celera6150,289,180 - 150,301,102 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032996   ⟸   NM_008970
- Peptide Label: preproprotein
- UniProtKB: P22858 (UniProtKB/Swiss-Prot),   Q540C1 (UniProtKB/TrEMBL),   Q924X4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000051433   ⟸   ENSMUST00000052296
Ensembl Acc Id: ENSMUSP00000145509   ⟸   ENSMUST00000204197

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22858-F1-model_v2 AlphaFold P22858 1-175 view protein structure

Promoters
RGD ID:6891546
Promoter ID:EPDNEW_M9224
Type:multiple initiation site
Name:Pthlh_1
Description:Mus musculus parathyroid hormone-like peptide , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M9225  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386147,263,868 - 147,263,928EPDNEW
RGD ID:6891548
Promoter ID:EPDNEW_M9225
Type:initiation region
Name:Pthlh_2
Description:Mus musculus parathyroid hormone-like peptide , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M9224  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386147,264,007 - 147,264,067EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97800 AgrOrtholog
Ensembl Genes ENSMUSG00000048776 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000052296 ENTREZGENE
  ENSMUST00000052296.9 UniProtKB/TrEMBL
  ENSMUST00000204197.2 UniProtKB/TrEMBL
InterPro PTH-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTH/PTH-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19227 UniProtKB/TrEMBL
MGD MGI:97800 ENTREZGENE
NCBI Gene 19227 ENTREZGENE
PANTHER PARATHYROID HORMONE-RELATED PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR17223 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Parathyroid UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pthlh PhenoGen
PROSITE PARATHYROID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PTH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P22858 ENTREZGENE, UniProtKB/Swiss-Prot
  Q540C1 ENTREZGENE, UniProtKB/TrEMBL
  Q811S6_MOUSE UniProtKB/TrEMBL
  Q924X4 ENTREZGENE, UniProtKB/TrEMBL