Ptgs1 (prostaglandin-endoperoxide synthase 1) - Rat Genome Database

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Gene: Ptgs1 (prostaglandin-endoperoxide synthase 1) Mus musculus
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Symbol: Ptgs1
Name: prostaglandin-endoperoxide synthase 1
RGD ID: 11184
MGI Page MGI
Description: Enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen and peroxidase activity. Involved in cyclooxygenase pathway and long-chain fatty acid biosynthetic process. Acts upstream of or within prostaglandin biosynthetic process; regulation of blood pressure; and regulation of cell population proliferation. Located in cytoplasm and photoreceptor outer segment. Is active in endoplasmic reticulum lumen. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and sensory organ. Used to study pre-eclampsia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human PTGS1 (prostaglandin-endoperoxide synthase 1).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: COX; Cox-; Cox-1; Cox-3; COX1; cyclooxygenase 1; cyclooxygenase-1; Pgh; PGH synthase 1; PGHS-1; Pghs1; PHS 1; prostaglandin G/H synthase 1; prostaglandin H2 synthase 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39236,106,758 - 36,142,287 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl236,120,438 - 36,142,284 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38236,216,742 - 36,258,593 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl236,230,426 - 36,252,272 (+)Ensemblmm10GRCm38
MGSCv37236,085,946 - 36,107,789 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36236,052,536 - 36,074,271 (+)NCBIMGSCv36mm8
Celera235,934,252 - 35,956,092 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map224.19NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-viniferin  (EXP)
(+)-beta-thujone  (ISO)
(+)-catechin  (EXP)
(+)-epicatechin-3-O-gallate  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-amygdalin  (ISO)
(R)-camphor  (ISO)
(R)-linalyl acetate  (ISO)
(S)-naringenin  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,4-phenylenediamine  (ISO)
1,8-cineole  (ISO)
1-(4'-hydroxy-3'-methoxyphenyl)-7-phenyl-3-heptanone  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (ISO)
12-HHTrE  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-[4-[3-[2-(trifluoromethyl)-9-thioxanthenylidene]propyl]-1-piperazinyl]ethanol  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-arachidonoylglycerol  (ISO)
24,25-Dihydroxyvitamin D  (ISO)
3,4-Methylenedioxyamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methylcholanthrene  (EXP)
4,4'-methylene-bis-(2-chloroaniline)  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
8-Br-cAMP  (ISO)
8-hydroxy-2'-deoxyguanosine  (ISO)
9-cis-retinoic acid  (ISO)
acetaldehyde  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
aliskiren  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (ISO)
alpha-pinene  (ISO)
aluminium atom  (EXP)
aluminium(0)  (EXP)
aminophenazone  (ISO)
ammonium chloride  (ISO)
amphibole asbestos  (ISO)
antipyrine  (ISO)
antirheumatic drug  (ISO)
apocynin  (ISO)
arachidonic acid  (EXP,ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
astemizole  (ISO)
atrazine  (ISO)
Azoxymethane  (ISO)
benzidine  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzo[b]fluoranthene  (EXP)
benzo[e]pyrene  (ISO)
Benzoylpaeoniflorin  (ISO)
beta-lapachone  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
budesonide  (ISO)
bumetanide  (EXP)
bupivacaine  (ISO)
buta-1,3-diene  (EXP)
butyric acid  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
cadmium sulfide  (ISO)
calciol  (EXP)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
camphor  (ISO)
carbon nanotube  (EXP)
carvedilol  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
creatinine  (ISO)
curcumin  (ISO)
cyclophosphamide  (EXP)
cyfluthrin  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
D-penicillamine  (ISO)
DDT  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diclofenac  (EXP,ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
docebenone  (EXP)
donepezil hydrochloride  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
DuP 697  (ISO)
enalapril  (EXP)
endosulfan  (ISO)
enniatin  (ISO)
entinostat  (ISO)
ethanol  (EXP)
etodolac  (ISO)
famotidine  (ISO)
fenofibrate  (ISO)
fenvalerate  (ISO)
ferric oxide  (ISO)
ferulic acid  (ISO)
fipronil  (ISO)
flavonoids  (ISO)
flunixin  (ISO)
fluoxetine  (ISO)
flupenthixol  (ISO)
flurbiprofen  (ISO)
flutamide  (ISO)
formaldehyde  (ISO)
furan  (ISO)
furosemide  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
glucose  (ISO)
glycine betaine  (ISO)
glyphosate  (ISO)
histamine  (ISO)
hydrogen chloride  (EXP)
hydrogen peroxide  (ISO)
ibuprofen  (EXP,ISO)
indometacin  (EXP,ISO)
isoliquiritigenin  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
ketorolac  (ISO)
L-ascorbic acid  (ISO)
leukotriene C4  (EXP)
leukotriene D4  (EXP)
leukotriene E4  (EXP)
linalool  (ISO)
linalyl acetate  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (ISO)
lornoxicam  (ISO)
lutein  (EXP)
lysophosphatidylcholine  (ISO)
Malabaricone C  (EXP)
MeIQx  (ISO)
meloxicam  (ISO)
mercury dibromide  (ISO)
metamizole sodium  (EXP,ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
miconazole  (ISO)
mifepristone  (ISO)
minocycline  (ISO)
Mitragynine  (EXP)
Mofezolac (TN)  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (EXP)
morphine  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nabumetone  (ISO)
naproxen  (ISO)
nickel dichloride  (EXP)
nickel subsulfide  (ISO)
nicotinic acid  (EXP,ISO)
nimesulide  (EXP,ISO)
nitrates  (EXP)
nitric oxide  (ISO)
nitrofen  (ISO)
NS-398  (ISO)
okadaic acid  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paeoniflorin  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
patchouli alcohol  (ISO)
Pentagastrin  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenacetin  (ISO)
phenobarbital  (EXP)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosgene  (EXP)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP,ISO)
prostaglandin E2  (EXP,ISO)
pyrazines  (EXP)
pyrethrins  (ISO)
Pyridostigmine bromide  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quartz  (ISO)
quercetin  (ISO)
Rebamipide  (ISO)
resveratrol  (EXP,ISO)
rivastigmine  (ISO)
rofecoxib  (ISO)
romidepsin  (ISO)
rotenone  (ISO)
S-adenosyl-L-methioninate  (EXP)
S-adenosyl-L-methionine  (EXP)
sabinene  (ISO)
SB 431542  (ISO)
SC-58125  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
sodium hydrogensulfite  (ISO)
sodium sulfite  (ISO)
spathulenol  (ISO)
streptozocin  (ISO)
succimer  (EXP,ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
Sulpyrine  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
thiostrepton  (ISO)
thromboxane A2  (EXP,ISO)
thromboxane B2  (EXP,ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP)
trans-piceid  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
urethane  (EXP,ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
wogonin  (EXP)
zinc atom  (ISO)
zinc oxide  (EXP)
zinc pyrithione  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acetylsalicylic acid pharmacodynamics pathway  (ISO)
antipyrine drug pathway  (ISO)
arachidonic acid metabolic pathway  (IEA,ISO)
celecoxib pharmacodynamics pathway  (ISO)
celecoxib pharmacokinetics pathway   (ISO)
cyclooxygenase mediated pathway of arachidonic acid metabolism  (ISO)
diclofenac pharmacodynamics pathway  (ISO)
diflunisal pharmacodynamics pathway  (ISO)
etodolac pharmacodynamics pathway  (ISO)
etoposide pharmacodynamics pathway  (ISO)
etoposide pharmacokinetics pathway  (ISO)
fenoprofen pharmacodynamics pathway  (ISO)
flurbiprofen pharmacodynamics pathway  (ISO)
ibuprofen pharmacodynamics pathway  (ISO)
ibuprofen pharmacokinetics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
ketoprofen pharmacodynamics pathway  (ISO)
ketorolac pharmacodynamics pathway  (ISO)
leukotriene C4 synthase deficiency pathway  (ISO)
lornoxicam pharmacodynamics pathway  (ISO)
magnesium salicylate pharmacodynamics pathway  (ISO)
mefenamic acid pharmacodynamics pathway  (ISO)
meloxicam pharmacodynamics pathway  (ISO)
nabumetone pharmacodynamics pathway  (ISO)
naproxen pharmacodynamics pathway   (ISO)
paracetamol drug pathway  (ISO)
piroxicam pharmacodynamics pathway   (ISO)
prostanoid biosynthetic pathway  (ISO)
salicylic acid pharmacodynamics pathway  (ISO)
sodium salicylate pharmacodynamics pathway  (ISO)
sulindac pharmacodynamics pathway  (ISO)
tenoxicam pharmacodynamics pathway  (ISO)
tiaprofenic acid pharmacodynamics pathway  (ISO)
tolmetin pharmacodynamics pathway  (ISO)
valdecoxib pharmacodynamics pathway  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal auditory brainstem response  (IEA)
abnormal blood coagulation  (IAGP)
abnormal blood flow velocity  (IAGP)
abnormal blood vessel physiology  (IAGP)
abnormal cecum morphology  (IEA)
abnormal circadian regulation of heart rate  (IAGP)
abnormal circadian regulation of systemic arterial blood pressure  (IAGP)
abnormal corpus luteum morphology  (IAGP)
abnormal drinking behavior  (IAGP)
abnormal keratinocyte differentiation  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal nociception after inflammation  (IAGP)
abnormal parturition  (IAGP)
abnormal response of heart to induced stress  (IAGP)
abnormal response/metabolism to endogenous compounds  (IAGP)
abnormal small intestine crypts of Lieberkuhn morphology  (IAGP)
abnormal stomach pH  (IAGP)
abnormal thromboxane level  (IAGP)
abnormal urine homeostasis  (IAGP)
abnormal uterine environment  (IAGP)
abnormal wound healing  (IAGP)
allodynia  (IAGP)
cyanosis  (IAGP)
decreased brain blood flow rate  (IAGP)
decreased digestive secretion  (IAGP)
decreased inflammatory response  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased platelet aggregation  (IAGP)
decreased prostaglandin level  (IAGP)
decreased susceptibility to induced arthritis  (IAGP)
decreased susceptibility to induced thrombosis  (IAGP)
decreased tumor incidence  (IAGP)
decreased urine prostaglandin level  (IAGP)
delayed parturition  (IAGP)
early parturition  (IAGP)
enlarged cecum  (IEA)
enlarged spleen  (IAGP)
hypotonia  (IAGP)
increased bleeding time  (IAGP)
increased bronchoconstrictive response  (IAGP)
increased cell proliferation  (IAGP)
increased cellular sensitivity to gamma-irradiation  (IAGP)
increased circulating progesterone level  (IAGP)
increased mean systemic arterial blood pressure  (IAGP)
increased prostaglandin level  (IAGP)
increased renal glomerular filtration rate  (IAGP)
increased renal vascular resistance  (IAGP)
increased small intestinal crypt cell apoptosis  (IAGP)
increased susceptibility to endotoxin shock  (IAGP)
increased susceptibility to induced colitis  (IAGP)
increased susceptibility to injury  (IAGP)
increased susceptibility to xenobiotic induced morbidity/mortality  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased thermal nociceptive threshold  (IAGP)
intestine polyps  (IAGP)
lactation failure  (IAGP)
maternal effect  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
patent ductus arteriosus  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality  (IAGP)
respiratory distress  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. COX-1 and COX-2 expression in stage I and II invasive cervical carcinoma: relationship to disease relapse and long-term survival. Athavale R, etal., Int J Gynecol Cancer. 2006 May-Jun;16(3):1303-8.
2. Cyclooxygenase expression and prostaglandin levels in central nervous system tissues during the course of chronic relapsing experimental autoimmune encephalomyelitis (EAE). Ayoub SS, etal., Inflamm Res. 2011 Oct;60(10):919-28. Epub 2011 Jun 12.
3. [Prognostic significance of cyclooxygenase (COX-1 and COX-2) expression in endometrial carcinoma (clinical and immunohistochemical study)] Boldarian NA, etal., Vopr Onkol. 2008;54(1):40-6.
4. Selective cyclooxygenase inhibition improves hepatic encephalopathy in fulminant hepatic failure of rat. Chang CC, etal., Eur J Pharmacol. 2011 Sep;666(1-3):226-32. Epub 2011 May 10.
5. Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid. Choi SH and Bosetti F, Aging (Albany NY). 2009 Feb 11;1(2):234-44.
6. Anti-inflammatory effect of low intensity ultrasound (LIUS) on complete Freund's adjuvant-induced arthritis synovium. Chung JI, etal., Osteoarthritis Cartilage. 2012 Jan 24.
7. Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer. Daikoku T, etal., Cancer Res. 2005 May 1;65(9):3735-44.
8. Cyclooxygenases-1 and -2 are differentially localized to microglia and endothelium in rat EAE and glioma. Deininger MH and Schluesener HJ, J Neuroimmunol. 1999 Mar 1;95(1-2):202-8.
9. Cyclooxygenase (COX)-1 expressing macrophages/microglial cells and COX-2 expressing astrocytes accumulate during oligodendroglioma progression. Deininger MH, etal., Brain Res. 2000 Dec 1;885(1):111-6.
10. Cyclooxygenase-1 and -2 in brains of patients who died with sporadic Creutzfeldt-Jakob disease. Deininger MH, etal., J Mol Neurosci. 2003 Feb;20(1):25-30.
11. Neuroprotective Effect of Cyclooxygenase Inhibitors in ICV-STZ Induced Sporadic Alzheimer's Disease in Rats. Dhull DK, etal., J Mol Neurosci. 2012 Jan;46(1):223-35. Epub 2011 Jun 24.
12. Elevated spinal cyclooxygenase and prostaglandin release during hyperalgesia in diabetic rats. Freshwater JD, etal., Diabetes 2002 Jul;51(7):2249-55.
13. The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings. Graham GG, etal., Inflammopharmacology. 2013 Jun;21(3):201-32. doi: 10.1007/s10787-013-0172-x. Epub 2013 May 30.
14. Cyclooxygenase-1 is overexpressed and promotes angiogenic growth factor production in ovarian cancer. Gupta RA, etal., Cancer Res. 2003 Mar 1;63(5):906-11.
15. Role of prostacyclin in the development of compression trauma-induced spinal cord injury in rats. Harada N, etal., J Neurotrauma. 2006 Dec;23(12):1739-49.
16. Minor salivary gland carcinoma: a review of 35 cases. Haymerle G, etal., Eur Arch Otorhinolaryngol. 2016 Sep;273(9):2717-26. doi: 10.1007/s00405-015-3805-4. Epub 2015 Oct 23.
17. Prostanoids as regulators of innate and adaptive immunity. Hirata T and Narumiya S, Adv Immunol. 2012;116:143-74. doi: 10.1016/B978-0-12-394300-2.00005-3.
18. Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer. Hwang D, etal., J Natl Cancer Inst. 1998 Mar 18;90(6):455-60.
19. Increased susceptibility to ischemic brain injury in cyclooxygenase-1-deficient mice. Iadecola C, etal., J Cereb Blood Flow Metab. 2001 Dec;21(12):1436-41.
20. The pathophysiological roles of COX-1 and COX-2 in the intestinal smooth muscle contractility under the anaphylactic condition. Kadowaki H, etal., Biomed Res. 2008 Apr;29(2):113-7.
21. Effects of genetic deficiency of cyclooxygenase-1 or cyclooxygenase-2 on functional and histological outcomes following traumatic brain injury in mice. Kelso ML, etal., BMC Neurosci. 2009 Aug 31;10:108.
22. Exploratory Translational Modeling Approach in Drug Development to Predict Human Brain Pharmacokinetics and Pharmacologically Relevant Clinical Doses. Kielbasa W and Stratford RE, Drug Metab Dispos. 2012 Jan 27.
23. Altered arachidonic acid cascade enzymes in postmortem brain from bipolar disorder patients. Kim HW, etal., Mol Psychiatry. 2011 Apr;16(4):419-28. Epub 2009 Dec 29.
24. Cyclooxygenase-1-derived prostaglandins in the periaqueductal gray differentially control C- versus A-fiber-evoked spinal nociception. Leith JL, etal., J Neurosci. 2007 Oct 17;27(42):11296-305.
25. 15d-prostaglandin J2 protects brain from ischemia-reperfusion injury. Lin TN, etal., Arterioscler Thromb Vasc Biol. 2006 Mar;26(3):481-7. Epub 2005 Dec 29.
26. Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newborn. Majed BH and Khalil RA, Pharmacol Rev. 2012 Jul;64(3):540-82. doi: 10.1124/pr.111.004770. Epub 2012 Jun 7.
27. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
28. MGDs mouse GO annotations MGD data from the GO Consortium
29. MGD IEA MGD IEA
30. Spinal prostaglandins facilitate exaggerated A- and C-fiber-mediated reflex responses and are critical to the development of allodynia early after L5-L6 spinal nerve ligation. O'Rielly DD and Loomis CW, Anesthesiology. 2007 Apr;106(4):795-805.
31. Down-regulation of cyclooxygenase-2 expression but up-regulation of cyclooxygenase-1 in renal carcinomas of the Eker (TSC2 gene mutant) rat model. Okamoto T, etal., Cancer Sci. 2003 Jan;94(1):22-5.
32. Aggravation by selective COX-1 and COX-2 inhibitors of dextran sulfate sodium (DSS)-induced colon lesions in rats. Okayama M, etal., Dig Dis Sci. 2007 Sep;52(9):2095-103. Epub 2007 Apr 12.
33. Characterization of the Prostaglandin E2 path way in a Rat Model of Esophageal Adenocarcinoma. Piazuelo E, etal., Curr Cancer Drug Targets. 2011 Oct 27.
34. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
35. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
36. Increased gene expression and production of spinal cyclooxygenase 1 and 2 during experimental osteoarthritis pain. Prochazkova M, etal., Physiol Res. 2008 Jul 18.
37. Mouse MP Annotation Import Pipeline RGD automated import pipeline
38. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
39. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
40. Upregulation of COX-1 and COX-2 in nasal polyps in cystic fibrosis. Roca-Ferrer J, etal., Thorax. 2006 Jul;61(7):592-6. Epub 2006 Mar 3.
41. Selective COX-2 inhibition markedly slows disease progression and attenuates altered prostanoid production in Han:SPRD-cy rats with inherited kidney disease. Sankaran D, etal., Am J Physiol Renal Physiol. 2007 Sep;293(3):F821-30. Epub 2007 May 30.
42. Selective accumulation of cyclooxygenase-1-expressing microglial cells/macrophages in lesions of human focal cerebral ischemia. Schwab JM, etal., Acta Neuropathol. 2000 Jun;99(6):609-14.
43. Persistent accumulation of cyclooxygenase-1 (COX-1) expressing microglia/macrophages and upregulation by endothelium following spinal cord injury. Schwab JM, etal., J Neuroimmunol. 2000 Nov 1;111(1-2):122-30.
44. Persistent accumulation of cyclooxygenase-1-expressing microglial cells and macrophages and transient upregulation by endothelium in human brain injury. Schwab JM, etal., J Neurosurg. 2002 May;96(5):892-9.
45. Traumatic brain injury induces prolonged accumulation of cyclooxygenase-1 expressing microglia/brain macrophages in rats. Schwab JM, etal., J Neurotrauma. 2001 Sep;18(9):881-90.
46. Involvement of cyclooxygenase-1 and -2 in the sciatic nerve of rats with experimental autoimmune neuritis. Shin T, etal., Immunol Invest. 2003 Aug;32(3):123-30.
47. Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Warden CH, etal., Genomics 1993 Nov;18(2):295-307.
48. Roles of vasoconstrictor prostaglandins, COX-1 and -2, and AT1, AT2, and TP receptors in a rat model of early 2K,1C hypertension. Welch WJ, etal., Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2644-9. Epub 2007 Aug 31.
49. Nasal mucosal expression of the leukotriene and prostanoid pathways in seasonal and perennial allergic rhinitis. Westergren VS, etal., Clin Exp Allergy. 2009 Jun;39(6):820-8. Epub 2009 Apr 2.
50. A novel animal model to investigate fractionated radiotherapy-induced alimentary mucositis: the role of apoptosis, p53, nuclear factor-kappaB, COX-1, and COX-2. Yeoh AS, etal., Mol Cancer Ther. 2007 Aug;6(8):2319-27.
51. Cyclooxygenase-1 in human Alzheimer and control brain: quantitative analysis of expression by microglia and CA3 hippocampal neurons. Yermakova AV, etal., J Neuropathol Exp Neurol. 1999 Nov;58(11):1135-46.
52. Activated microglia in the human glaucomatous optic nerve head. Yuan L and Neufeld AH, J Neurosci Res. 2001 Jun 1;64(5):523-32.
53. Cyclooxygenase-1 in the spinal cord is altered after peripheral nerve injury. Zhu X and Eisenach JC, Anesthesiology. 2003 Nov;99(5):1175-9.
Additional References at PubMed
PMID:1536575   PMID:1712772   PMID:2108169   PMID:2109618   PMID:2788176   PMID:7514040   PMID:8000136   PMID:8070358   PMID:8071353   PMID:8105016   PMID:8121489   PMID:8244399  
PMID:8424659   PMID:8449520   PMID:8521478   PMID:8631881   PMID:8643612   PMID:8719346   PMID:8827514   PMID:8882280   PMID:8889548   PMID:8914934   PMID:8994299   PMID:9013559  
PMID:9156514   PMID:9256365   PMID:9346237   PMID:9362331   PMID:9463402   PMID:9514655   PMID:9665805   PMID:9751758   PMID:10051620   PMID:10216176   PMID:10330429   PMID:10342859  
PMID:10349636   PMID:10411296   PMID:10438476   PMID:10449516   PMID:10487525   PMID:10491407   PMID:10534105   PMID:10548515   PMID:10593166   PMID:10630643   PMID:10651981   PMID:10668482  
PMID:10683376   PMID:10727451   PMID:10780854   PMID:10803598   PMID:10841517   PMID:10944235   PMID:10954756   PMID:10987272   PMID:11017920   PMID:11042159   PMID:11052981   PMID:11076861  
PMID:11158594   PMID:11217851   PMID:11282894   PMID:11416042   PMID:11444591   PMID:11489266   PMID:11694451   PMID:11705824   PMID:11832369   PMID:11936618   PMID:12021206   PMID:12045254  
PMID:12050136   PMID:12054171   PMID:12055598   PMID:12067981   PMID:12093889   PMID:12118094   PMID:12163371   PMID:12183660   PMID:12184998   PMID:12189188   PMID:12189249   PMID:12213634  
PMID:12355421   PMID:12411530   PMID:12466851   PMID:12477932   PMID:12576525   PMID:12657565   PMID:12664644   PMID:12713596   PMID:12775764   PMID:12835322   PMID:12922938   PMID:12941808  
PMID:12958020   PMID:14625089   PMID:14630706   PMID:14632179   PMID:14638539   PMID:14681479   PMID:14701858   PMID:14718360   PMID:15084473   PMID:15181007   PMID:15240726   PMID:15263079  
PMID:15313895   PMID:15358864   PMID:15451306   PMID:15489334   PMID:15542509   PMID:15650114   PMID:15699263   PMID:15776109   PMID:15831902   PMID:15863457   PMID:15883230   PMID:16081878  
PMID:16140261   PMID:16141072   PMID:16141073   PMID:16179345   PMID:16189289   PMID:16204198   PMID:16272346   PMID:16373427   PMID:16380543   PMID:16493486   PMID:16518767   PMID:16554545  
PMID:16556900   PMID:16614756   PMID:16627484   PMID:16630131   PMID:16675300   PMID:16688111   PMID:16732282   PMID:16787386   PMID:16787416   PMID:16815697   PMID:16842596   PMID:16857891  
PMID:16869965   PMID:16875891   PMID:16955389   PMID:17038629   PMID:17085013   PMID:17110378   PMID:17130451   PMID:17145980   PMID:17219415   PMID:17266762   PMID:17328923   PMID:17364940  
PMID:17438133   PMID:17454003   PMID:17505022   PMID:17546626   PMID:17641673   PMID:17641732   PMID:17643885   PMID:17673547   PMID:17674023   PMID:17916350   PMID:17921329   PMID:17933963  
PMID:17959725   PMID:17982097   PMID:17982098   PMID:17993463   PMID:18162486   PMID:18292449   PMID:18355636   PMID:18378794   PMID:18419601   PMID:18480244   PMID:18514659   PMID:18523303  
PMID:18584335   PMID:18676373   PMID:18753249   PMID:18772366   PMID:18833324   PMID:19056763   PMID:19098906   PMID:19114118   PMID:19193887   PMID:19375854   PMID:19416639   PMID:19523994  
PMID:19658194   PMID:19711010   PMID:19767186   PMID:19828811   PMID:19843949   PMID:19844242   PMID:19865483   PMID:19885646   PMID:20034541   PMID:20061361   PMID:20065147   PMID:20083684  
PMID:20107114   PMID:20236942   PMID:20304815   PMID:20412387   PMID:20585313   PMID:20606163   PMID:20724703   PMID:20880987   PMID:21094252   PMID:21267068   PMID:21307302   PMID:21357261  
PMID:21680698   PMID:21694498   PMID:21858200   PMID:21873635   PMID:22001217   PMID:22022466   PMID:22080487   PMID:22185794   PMID:22219191   PMID:22371360   PMID:22406532   PMID:22412193  
PMID:22522619   PMID:22902502   PMID:23045674   PMID:23178857   PMID:23305935   PMID:23337807   PMID:23449692   PMID:23742950   PMID:23817787   PMID:23850620   PMID:23874970   PMID:23877023  
PMID:23966321   PMID:23986518   PMID:23987235   PMID:24003143   PMID:24005111   PMID:24009185   PMID:24014678   PMID:24020373   PMID:24086110   PMID:24154525   PMID:24200680   PMID:24316575  
PMID:24469308   PMID:24668417   PMID:24833393   PMID:24845831   PMID:24878773   PMID:24944008   PMID:25030064   PMID:25131634   PMID:25149102   PMID:25164664   PMID:25432964   PMID:25492024  
PMID:25757568   PMID:26017977   PMID:26215112   PMID:26444418   PMID:26586201   PMID:26690700   PMID:26712011   PMID:26841868   PMID:27059285   PMID:27060751   PMID:27386631   PMID:27425247  
PMID:27689697   PMID:27845343   PMID:27899360   PMID:28069828   PMID:28287401   PMID:28413018   PMID:28684424   PMID:28754971   PMID:28846746   PMID:28954232   PMID:29029054   PMID:29180445  
PMID:29228266   PMID:29676940   PMID:29678951   PMID:29958798   PMID:30108257   PMID:30550785   PMID:30575026   PMID:30760327   PMID:30811756   PMID:31015404   PMID:31243090   PMID:31248980  
PMID:31510878   PMID:31597917   PMID:31772225   PMID:32259636   PMID:32325033   PMID:32408168   PMID:32592197   PMID:32747435   PMID:32913122   PMID:33476547   PMID:33741600   PMID:33806238  
PMID:33846639   PMID:33941650   PMID:34321999   PMID:34348138   PMID:34389796   PMID:35588739   PMID:35624708   PMID:36241001   PMID:36252026   PMID:38355793   PMID:38660804   PMID:38690712  
PMID:39082135   PMID:39377223   PMID:40044852  


Genomics

Comparative Map Data
Ptgs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39236,106,758 - 36,142,287 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl236,120,438 - 36,142,284 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38236,216,742 - 36,258,593 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl236,230,426 - 36,252,272 (+)Ensemblmm10GRCm38
MGSCv37236,085,946 - 36,107,789 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36236,052,536 - 36,074,271 (+)NCBIMGSCv36mm8
Celera235,934,252 - 35,956,092 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map224.19NCBI
PTGS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389122,370,533 - 122,395,703 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9122,370,530 - 122,395,703 (+)Ensemblhg38GRCh38
GRCh379125,132,812 - 125,157,982 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369124,173,050 - 124,197,802 (+)NCBIBuild 36Build 36hg18NCBI36
Build 349122,212,782 - 122,237,535NCBI
Celera995,781,549 - 95,806,298 (+)NCBICelera
Cytogenetic Map9q33.2NCBI
HuRef994,747,532 - 94,772,698 (+)NCBIHuRef
CHM1_19125,280,871 - 125,306,038 (+)NCBICHM1_1
T2T-CHM13v2.09134,568,002 - 134,593,163 (+)NCBIT2T-CHM13v2.0
Ptgs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8339,981,419 - 40,002,993 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl339,981,415 - 40,002,990 (+)EnsemblGRCr8
mRatBN7.2319,584,015 - 19,605,589 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl319,584,015 - 19,605,586 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx322,661,928 - 22,683,470 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0331,246,853 - 31,268,395 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0329,494,672 - 29,516,226 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0315,560,685 - 15,582,339 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl315,560,712 - 15,582,344 (+)Ensemblrn6Rnor6.0
Rnor_5.0320,869,915 - 20,891,512 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4315,343,832 - 15,365,412 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera314,295,836 - 14,317,392 (+)NCBICelera
RGSC_v3.1315,240,203 - 15,261,784 (+)NCBI
Cytogenetic Map3p11NCBI
Ptgs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554195,678,694 - 5,699,305 (-)Ensembl
ChiLan1.0NW_0049554195,678,750 - 5,699,305 (-)NCBIChiLan1.0ChiLan1.0
PTGS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21116,953,759 - 16,975,988 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1916,953,703 - 16,978,307 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0993,495,365 - 93,517,557 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19121,837,095 - 121,859,283 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9121,837,095 - 121,859,283 (+)EnsemblpanPan2panpan1.1
PTGS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1960,195,118 - 60,216,847 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl960,195,124 - 60,216,819 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha959,390,579 - 59,412,227 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0961,110,468 - 61,132,351 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl961,110,470 - 61,132,343 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1959,884,516 - 59,906,289 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0960,200,281 - 60,222,098 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0960,289,919 - 60,311,671 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ptgs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947190,976,385 - 190,990,294 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648710,745,327 - 10,758,823 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648710,745,465 - 10,758,812 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1262,456,155 - 262,483,035 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11262,456,106 - 262,482,159 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21294,753,789 - 294,779,835 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTGS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11217,195,403 - 17,218,450 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1217,192,628 - 17,218,315 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603525,831,631 - 25,856,861 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptgs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476012,915,206 - 12,937,824 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476012,917,244 - 12,937,858 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Ptgs1
1698 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:791
Count of miRNA genes:529
Interacting mature miRNAs:633
Transcripts:ENSMUST00000062069, ENSMUST00000133777, ENSMUST00000144319, ENSMUST00000149930, ENSMUST00000151351
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212953766556453Mouse
12904005Cfq2_mconditioned fear QTL 2 (mouse)22702264256396228Mouse
14746979Manh51_mmandible shape 51 (mouse)22896112962961129Mouse
1300624Insq7_minsulin QTL 7 (mouse)Not determined2938444643384575Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
4142133Pbwg1.6_mpostnatal body weight growth 1.6 (mouse)Not determined3579732469797406Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31214567105143570Mouse
26884438Sklq12_mskull length QTL 12, 16 week (mouse)22459001254890012Mouse
12904008Cfq6_mconditioned fear QTL 6 (mouse)23120303544508204Mouse
1301790Pcfm1_mperiosteal circumference and femur length 1 (mouse)Not determined2823629642236396Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
4142130Pgis2_mproteoglycan induced spondylitis 2 (mouse)Not determined22530805156971811Mouse
1559001Eae33_mexperimental allergic encephalomyelitis susceptibility 33 (mouse)Not determined23599167971609412Mouse
1301980Fcsa5_mfemoral cross-sectional area 5 (mouse)Not determined2767911541679261Mouse
4142447Pbwg1.7_mpostnatal body weight growth 1.7 (mouse)Not determined3579732469797406Mouse
1301376Etohc1_methanol consumption 1 (mouse)Not determined22112972555129871Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
14746997Mancz2_mmandible centroid size 2 (mouse)22896112962961129Mouse
12792980Fbmd1_mfemoral bone mineral density 1, females only (mouse)22503449245034492Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1301641Sbmd2_mspinal bone mineral density 2 (mouse)Not determined21421456748214713Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
10755513Amzn4_manatomical modifier of Zfp423 4 (mouse)2938444643384575Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
13463470Tubisq1_mtubulointerstitial injury severity, QTL 1 (mouse)22368914557689269Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
13464253Ifvrq1_minfluenza virus resistance QTL 1 (mouse)23303449252034492Mouse
1300577Capsq1_mcapsaicin sensitivity related QTL 1 (mouse)Not determined22760206084013384Mouse
4141708Pbwg1.2_mpostnatal body weight growth 1.2 (mouse)Not determined2112972555129871Mouse
10043876Adip22_madiposity 22 (mouse)Not determined2830805142308240Mouse
4141186Pbwg1.8_mpostnatal body weight growth 1.8 (mouse)Not determined3579732469797406Mouse

Markers in Region
M34141  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38236,252,078 - 36,252,171UniSTSGRCm38
MGSCv37236,107,598 - 36,107,691UniSTSGRCm37
Celera235,955,901 - 35,955,994UniSTS
Cytogenetic Map2BUniSTS
cM Map229.0UniSTS
Whitehead/MRC_RH2668.42UniSTS
Whitehead/MRC_RH2663.19UniSTS
Ptgs1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2BUniSTS
cM Map229.0UniSTS
PMC14708P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38236,251,002 - 36,251,602UniSTSGRCm38
MGSCv37236,106,522 - 36,107,122UniSTSGRCm37
Celera235,954,825 - 35,955,425UniSTS
Cytogenetic Map2BUniSTS
cM Map229.0UniSTS
Ptgs1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2BUniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006497790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006497791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006497794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011239036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH015269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH015270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK046352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK046457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK134163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL929054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW493573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY547265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY467854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY467855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M34141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000062069   ⟹   ENSMUSP00000059977
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl236,120,438 - 36,142,284 (+)Ensembl
GRCm38.p6 Ensembl236,230,426 - 36,252,272 (+)Ensembl
Ensembl Acc Id: ENSMUST00000133777
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl236,132,487 - 36,135,217 (+)Ensembl
GRCm38.p6 Ensembl236,242,475 - 36,245,205 (+)Ensembl
Ensembl Acc Id: ENSMUST00000144319
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl236,120,568 - 36,128,075 (+)Ensembl
GRCm38.p6 Ensembl236,230,556 - 36,238,063 (+)Ensembl
Ensembl Acc Id: ENSMUST00000149930
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl236,126,261 - 36,142,281 (+)Ensembl
GRCm38.p6 Ensembl236,236,249 - 36,252,269 (+)Ensembl
Ensembl Acc Id: ENSMUST00000151351
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl236,130,725 - 36,131,480 (+)Ensembl
GRCm38.p6 Ensembl236,240,713 - 36,241,468 (+)Ensembl
RefSeq Acc Id: NM_008969   ⟹   NP_032995
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39236,120,438 - 36,142,284 (+)NCBI
GRCm38236,230,426 - 36,252,272 (+)NCBI
MGSCv37236,085,946 - 36,107,789 (+)RGD
Celera235,934,252 - 35,956,095 (+)NCBI
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006497790   ⟹   XP_006497853
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39236,106,758 - 36,142,287 (+)NCBI
GRCm38236,216,744 - 36,258,593 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006497791   ⟹   XP_006497854
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39236,106,758 - 36,142,287 (+)NCBI
GRCm38236,216,744 - 36,258,593 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006497794   ⟹   XP_006497857
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39236,125,129 - 36,142,287 (+)NCBI
GRCm38236,235,099 - 36,258,593 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011239036   ⟹   XP_011237338
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39236,106,758 - 36,142,287 (+)NCBI
GRCm38236,216,744 - 36,258,593 (+)NCBI
Sequence:
RefSeq Acc Id: NP_032995   ⟸   NM_008969
- Peptide Label: precursor
- UniProtKB: P22437 (UniProtKB/Swiss-Prot),   Q543T1 (UniProtKB/TrEMBL),   Q8CIL6 (UniProtKB/TrEMBL),   Q3UZ23 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006497853   ⟸   XM_006497790
- Peptide Label: isoform X1
- UniProtKB: P22437 (UniProtKB/Swiss-Prot),   Q543T1 (UniProtKB/TrEMBL),   Q8CIL6 (UniProtKB/TrEMBL),   Q3UZ23 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006497854   ⟸   XM_006497791
- Peptide Label: isoform X1
- UniProtKB: P22437 (UniProtKB/Swiss-Prot),   Q543T1 (UniProtKB/TrEMBL),   Q8CIL6 (UniProtKB/TrEMBL),   Q3UZ23 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006497857   ⟸   XM_006497794
- Peptide Label: isoform X2
- UniProtKB: Q3UZ23 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011237338   ⟸   XM_011239036
- Peptide Label: isoform X1
- UniProtKB: P22437 (UniProtKB/Swiss-Prot),   Q543T1 (UniProtKB/TrEMBL),   Q8CIL6 (UniProtKB/TrEMBL),   Q3UZ23 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000059977   ⟸   ENSMUST00000062069
Protein Domains
EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22437-F1-model_v2 AlphaFold P22437 1-602 view protein structure

Promoters
RGD ID:6832215
Promoter ID:MM_KWN:28924
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   Kidney
Transcripts:OTTMUST00000028971,   OTTMUST00000028972
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36236,085,814 - 36,086,314 (+)MPROMDB
RGD ID:6832220
Promoter ID:MM_KWN:28925
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1
Transcripts:OTTMUST00000028973
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36236,090,981 - 36,091,481 (+)MPROMDB
RGD ID:6832218
Promoter ID:MM_KWN:28926
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1
Transcripts:OTTMUST00000028974
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36236,096,031 - 36,096,531 (+)MPROMDB
RGD ID:6832219
Promoter ID:MM_KWN:28927
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000028975
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36236,098,106 - 36,098,606 (+)MPROMDB
RGD ID:6877168
Promoter ID:EPDNEW_M2035
Type:initiation region
Name:Ptgs1_1
Description:Mus musculus prostaglandin-endoperoxide synthase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38236,230,500 - 36,230,560EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97797 AgrOrtholog
Ensembl Genes ENSMUSG00000047250 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000062069 ENTREZGENE
  ENSMUST00000062069.6 UniProtKB/Swiss-Prot
  ENSMUST00000149930 ENTREZGENE
Gene3D-CATH 1.10.640.10 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
InterPro EGF-like_dom UniProtKB/Swiss-Prot
  Haem_peroxidase_animal UniProtKB/Swiss-Prot
  Haem_peroxidase_sf UniProtKB/Swiss-Prot
  Haem_peroxidase_sf_animal UniProtKB/Swiss-Prot
  Oxylipin_biosynth_metab UniProtKB/Swiss-Prot
KEGG Report mmu:19224 UniProtKB/Swiss-Prot
MGD MGI:97797 ENTREZGENE
NCBI Gene 19224 ENTREZGENE
PANTHER PROSTAGLANDIN G/H SYNTHASE UniProtKB/Swiss-Prot
  PTHR11903:SF6 UniProtKB/Swiss-Prot
Pfam An_peroxidase UniProtKB/Swiss-Prot
PharmGKB PTGS1 RGD
PhenoGen Ptgs1 PhenoGen
PRINTS ANPEROXIDASE UniProtKB/Swiss-Prot
PROSITE EGF_3 UniProtKB/Swiss-Prot
  PEROXIDASE_3 UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  SSF48113 UniProtKB/Swiss-Prot
UniProt P22437 ENTREZGENE, UniProtKB/Swiss-Prot
  Q3TJN9_MOUSE UniProtKB/TrEMBL
  Q3UZ23 ENTREZGENE, UniProtKB/TrEMBL
  Q543T1 ENTREZGENE, UniProtKB/TrEMBL
  Q6QDC8_MOUSE UniProtKB/TrEMBL
  Q8CIL6 ENTREZGENE