Prnp (prion protein) - Rat Genome Database

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Gene: Prnp (prion protein) Mus musculus
Analyze
Symbol: Prnp
Name: prion protein
RGD ID: 11160
MGI Page MGI
Description: Enables several functions, including amyloid-beta binding activity; aspartic-type endopeptidase inhibitor activity; and cupric ion binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of protein phosphorylation; and regulation of signal transduction. Acts upstream of or within several processes, including negative regulation of apoptotic process; regulation of potassium ion transmembrane transport; and response to oxidative stress. Located in several cellular components, including Golgi apparatus; membrane raft; and terminal bouton. Colocalizes with dendrite. Is expressed in several structures, including cardiovascular system; genitourinary system; nervous system; sensory organ; and tooth. Used to study Creutzfeldt-Jakob disease; Gerstmann-Straussler-Scheinker syndrome; and fatal familial insomnia. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease; Gerstmann-Straussler-Scheinker syndrome; Huntington's disease-like 1; fatal familial insomnia; and kuru. Orthologous to human PRNP (prion protein (Kanno blood group)).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AA960666; AI325101; CD230; major prion protein; P; Prn-i; Prn-p; PrP; prP27-30; prP33-35C; PrP; PrPC; PrPSc; S; Sinc
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392131,751,848 - 131,780,356 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2131,751,848 - 131,780,349 (+)EnsemblGRCm39 Ensembl
GRCm382131,909,928 - 131,938,436 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2131,909,928 - 131,938,429 (+)EnsemblGRCm38mm10GRCm38
MGSCv372131,735,664 - 131,764,167 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362131,601,398 - 131,629,868 (+)NCBIMGSCv36mm8
Celera2133,143,177 - 133,164,079 (+)NCBICelera
Cytogenetic Map2F2NCBI
cM Map264.07NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (EXP)
(E)-thiamethoxam  (EXP)
1,2-dichloroethane  (EXP)
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine  (ISO)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (ISO)
2,2,2-trifluoroethanol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-methoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-dichloroaniline  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
bathocuproine disulfonic acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoates  (ISO)
beta-lapachone  (ISO)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bortezomib  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
Congo Red  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cytarabine  (ISO)
D-glucose  (ISO)
diarsenic trioxide  (ISO)
dichloromethane  (ISO)
diethyldithiocarbamic acid  (ISO)
dioxygen  (EXP,ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
edaravone  (ISO)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (ISO)
ethylenediaminetetraacetic acid  (EXP)
etoposide  (ISO)
fenthion  (EXP)
filipin III  (EXP,ISO)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
furan  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
glucose  (ISO)
glutathione  (EXP)
glyphosate  (ISO)
graphene oxide  (ISO)
GW 1929  (ISO)
heparan sulfate  (EXP)
hydrogen peroxide  (EXP,ISO)
indoxyl sulfate  (ISO)
inulin  (EXP)
iron atom  (EXP)
iron(0)  (EXP)
lead diacetate  (EXP)
lead tetraacetate  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (EXP)
luzindole  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
melatonin  (ISO)
mercury dibromide  (ISO)
metam  (EXP)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
NADP zwitterion  (EXP,ISO)
NADP(+)  (EXP,ISO)
nickel atom  (EXP,ISO)
nickel sulfate  (ISO)
nitroprusside  (ISO)
nystatin  (EXP,ISO)
o-xylene  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (EXP)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP)
progesterone  (ISO)
Pyridostigmine bromide  (ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sodium arsenite  (ISO)
tamibarotene  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thapsigargin  (ISO)
thiamethoxam  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
topotecan  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
zinc atom  (EXP)
zinc oxide  (ISO)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (IGI)
amyloid precursor protein metabolic process  (IGI)
cellular response to amyloid-beta  (IGI,ISO)
cellular response to copper ion  (ISO)
cellular response to xenobiotic stimulus  (IDA)
intracellular copper ion homeostasis  (TAS)
learning or memory  (IGI,ISO)
negative regulation of activated T cell proliferation  (IMP)
negative regulation of amyloid precursor protein catabolic process  (IGI)
negative regulation of amyloid-beta formation  (IGI)
negative regulation of apoptotic process  (IGI,ISO)
negative regulation of calcineurin-NFAT signaling cascade  (IMP)
negative regulation of catalytic activity  (ISO)
negative regulation of dendritic spine maintenance  (IGI)
negative regulation of DNA-binding transcription factor activity  (IMP)
negative regulation of interleukin-17 production  (IMP)
negative regulation of interleukin-2 production  (IMP)
negative regulation of long-term synaptic potentiation  (IEA,ISO)
negative regulation of protein phosphorylation  (IMP)
negative regulation of T cell receptor signaling pathway  (IMP)
negative regulation of type II interferon production  (IMP)
neuron projection maintenance  (IGI)
nucleobase-containing compound metabolic process  (TAS)
positive regulation of calcium-mediated signaling  (IGI,ISO)
positive regulation of glutamate receptor signaling pathway  (IEA,ISO)
positive regulation of neuron apoptotic process  (IEA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IMP,ISO)
positive regulation of protein localization to plasma membrane  (IMP,ISO)
positive regulation of protein targeting to membrane  (IGI)
protein destabilization  (IEA,ISO)
protein homooligomerization  (IEA)
regulation of calcium ion import across plasma membrane  (IGI)
regulation of glutamate receptor signaling pathway  (IGI)
regulation of peptidyl-tyrosine phosphorylation  (IGI)
regulation of potassium ion transmembrane transport  (IGI)
regulation of protein localization  (IMP)
response to amyloid-beta  (IGI)
response to cadmium ion  (IEA,ISO)
response to copper ion  (ISO)
response to oxidative stress  (IDA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal afterhyperpolarization  (IAGP)
abnormal B cell morphology  (IAGP)
abnormal behavior  (IAGP)
abnormal body temperature homeostasis  (IAGP)
abnormal brain morphology  (IAGP)
abnormal brain white matter morphology  (IAGP)
abnormal cerebellar molecular layer  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal cingulum morphology  (IAGP)
abnormal CNS synaptic transmission  (IAGP)
abnormal copper level  (IAGP)
abnormal corpus callosum morphology  (IAGP)
abnormal excitatory postsynaptic potential  (IAGP)
abnormal gait  (IAGP)
abnormal hippocampus CA1 region morphology  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal hippocampus stratum lacunosum morphology  (IAGP)
abnormal inhibitory postsynaptic currents  (IAGP)
abnormal inhibitory postsynaptic potential  (IAGP)
abnormal magnesium ion homeostasis  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal motor learning  (IAGP)
abnormal muscle fiber morphology  (IAGP)
abnormal muscle physiology  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuron proliferation  (IAGP)
abnormal neuronal precursor proliferation  (IAGP)
abnormal object recognition memory  (IAGP)
abnormal olfactory bulb morphology  (IAGP)
abnormal response to novel object  (IAGP)
abnormal retina morphology  (IAGP)
abnormal sciatic nerve morphology  (IAGP)
abnormal sleep duration  (IAGP)
abnormal sleep pattern  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal susceptibility to infection  (IAGP)
abnormal susceptibility to prion infection  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal tail morphology  (IAGP)
abnormal thalamus morphology  (IAGP)
abnormal voluntary movement  (IAGP)
amyloid beta deposits  (IAGP)
astrocytosis  (IAGP)
ataxia  (IAGP)
brain vacuoles  (IAGP)
cerebellum atrophy  (IAGP)
circling  (IAGP)
decreased anxiety-related response  (IAGP)
decreased body weight  (IAGP)
decreased brain copper level  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased DN2 thymocyte number  (IAGP)
decreased DN4 thymocyte number  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased grooming behavior  (IAGP)
decreased locomotor activity  (IAGP)
decreased neuron number  (IAGP)
decreased Purkinje cell number  (IAGP)
decreased Purkinje cell size  (IAGP)
decreased susceptibility to prion infection  (IAGP)
decreased thymocyte number  (IAGP)
decreased vertical activity  (IAGP)
dysmetria  (IAGP)
enlarged brain ventricles  (IAGP)
gliosis  (IAGP)
hindlimb paralysis  (IAGP)
hippocampal neuron degeneration  (IAGP)
hyperactivity  (IAGP)
impaired acrosome reaction  (IAGP)
impaired balance  (IAGP)
impaired coordination  (IAGP)
impaired fertilization  (IAGP)
impaired righting response  (IAGP)
increased brain copper level  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased DN3 thymocyte number  (IAGP)
increased double-negative T cell number  (IAGP)
increased gamma-delta T cell number  (IAGP)
increased neuron apoptosis  (IAGP)
increased pruritus  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased susceptibility to prion infection  (IAGP)
kyphosis  (IAGP)
lethargy  (IAGP)
limb grasping  (IAGP)
male infertility  (IAGP)
microgliosis  (IAGP)
muscle degeneration  (IAGP)
muscular atrophy  (IAGP)
myoclonus  (IAGP)
neurodegeneration  (IAGP)
neuron degeneration  (IAGP)
neuronal intranuclear inclusions  (IAGP)
no abnormal phenotype detected  (IAGP)
paraparesis  (IAGP)
paresis  (IAGP)
premature death  (IAGP)
premature neuronal precursor differentiation  (IAGP)
Purkinje cell degeneration  (IAGP)
reduced long-term potentiation  (IAGP)
spongiform encephalopathy  (IAGP)
teratozoospermia  (IAGP)
thin cerebellar molecular layer  (IAGP)
thymus atrophy  (IAGP)
thymus hypoplasia  (IAGP)
tremors  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease. Bogdan AR, etal., Trends Biochem Sci. 2016 Mar;41(3):274-86. doi: 10.1016/j.tibs.2015.11.012. Epub 2015 Dec 23.
2. Creutzfeldt-Jacob disease associated with the PRNP codon 200Lys mutation: an analysis of 45 families. Goldfarb LG, etal., Eur J Epidemiol. 1991 Sep;7(5):477-86.
3. A novel vector for transgenesis in the rat CNS. Lopez TP, etal., Acta Neuropathol Commun. 2017 Nov 21;5(1):84. doi: 10.1186/s40478-017-0484-y.
4. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Pronounced cytosolic aggregation of cellular prion protein in pancreatic beta-cells in response to hyperglycemia. Strom A, etal., Lab Invest. 2006 Dec 4;.
Additional References at PubMed
PMID:1353438   PMID:1373228   PMID:1670551   PMID:1672162   PMID:1676894   PMID:1681406   PMID:1685143   PMID:1687379   PMID:1687380   PMID:1687381   PMID:1687385   PMID:1870200  
PMID:1968507   PMID:1970329   PMID:1970330   PMID:2575583   PMID:2859120   PMID:2884041   PMID:2890436   PMID:2894984   PMID:3015416   PMID:3094007   PMID:3149717   PMID:3462700  
PMID:3923361   PMID:4970191   PMID:6801762   PMID:7494265   PMID:7512619   PMID:7553876   PMID:7558020   PMID:7609638   PMID:7622046   PMID:7719349   PMID:7842304   PMID:7902565  
PMID:7904753   PMID:7907357   PMID:7911243   PMID:7911437   PMID:7912659   PMID:7912827   PMID:7913753   PMID:7913762   PMID:7962730   PMID:7999308   PMID:8030944   PMID:8030958  
PMID:8035877   PMID:8095862   PMID:8100741   PMID:8118101   PMID:8407244   PMID:8462855   PMID:8552188   PMID:8602267   PMID:8606772   PMID:8617512   PMID:8634020   PMID:8635458  
PMID:8637886   PMID:8651915   PMID:8698234   PMID:8700211   PMID:8734907   PMID:8757019   PMID:8758005   PMID:8790598   PMID:8845956   PMID:8917559   PMID:8944151   PMID:8982352  
PMID:9016962   PMID:9030645   PMID:9031631   PMID:9163538   PMID:9186056   PMID:9207082   PMID:9212101   PMID:9242048   PMID:9280298   PMID:9294164   PMID:9294167   PMID:9321385  
PMID:9333232   PMID:9353594   PMID:9363892   PMID:9371744   PMID:9414161   PMID:9450236   PMID:9462739   PMID:9523587   PMID:9568713   PMID:9582258   PMID:9590434   PMID:9636277  
PMID:9754876   PMID:9770528   PMID:9792790   PMID:9799790   PMID:9837873   PMID:9867802   PMID:9876879   PMID:9883727   PMID:9932423   PMID:10037495   PMID:10086355   PMID:10102274  
PMID:10349636   PMID:10352232   PMID:10378511   PMID:10421360   PMID:10461901   PMID:10477271   PMID:10521590   PMID:10525406   PMID:10529232   PMID:10545999   PMID:10550328   PMID:10581259  
PMID:10656806   PMID:10708751   PMID:10805813   PMID:10818004   PMID:10842180   PMID:10900000   PMID:10922068   PMID:10930132   PMID:10954563   PMID:10985358   PMID:10987828   PMID:11032800  
PMID:11038396   PMID:11042159   PMID:11073804   PMID:11076861   PMID:11130978   PMID:11152514   PMID:11152682   PMID:11179214   PMID:11208919   PMID:11217851   PMID:11239719   PMID:11259483  
PMID:11259607   PMID:11263978   PMID:11274428   PMID:11278539   PMID:11300723   PMID:11300727   PMID:11312611   PMID:11333913   PMID:11353827   PMID:11359769   PMID:11369504   PMID:11438139  
PMID:11438695   PMID:11546838   PMID:11566872   PMID:11571277   PMID:11697729   PMID:11697909   PMID:11716303   PMID:11742063   PMID:11743735   PMID:11756421   PMID:11775003   PMID:11782965  
PMID:11792852   PMID:11823413   PMID:11842265   PMID:11846415   PMID:11860274   PMID:11867531   PMID:11903999   PMID:11904434   PMID:11912192   PMID:11924867   PMID:11950500   PMID:12034448  
PMID:12051707   PMID:12070160   PMID:12084159   PMID:12091459   PMID:12093732   PMID:12093733   PMID:12130636   PMID:12151775   PMID:12163492   PMID:12206674   PMID:12215421   PMID:12271119  
PMID:12379130   PMID:12383347   PMID:12386336   PMID:12386337   PMID:12387871   PMID:12411613   PMID:12425947   PMID:12431994   PMID:12435392   PMID:12446843   PMID:12456643   PMID:12459456  
PMID:12466851   PMID:12477932   PMID:12481985   PMID:12500977   PMID:12519913   PMID:12529324   PMID:12556465   PMID:12621436   PMID:12663673   PMID:12664293   PMID:12679564   PMID:12684540  
PMID:12758067   PMID:12759361   PMID:12794132   PMID:12805223   PMID:12853456   PMID:12871949   PMID:12876477   PMID:12878182   PMID:12904479   PMID:12911750   PMID:12914944   PMID:12927782  
PMID:12933795   PMID:14511115   PMID:14515989   PMID:14525996   PMID:14570892   PMID:14573822   PMID:14593181   PMID:14597699   PMID:14622086   PMID:14625012   PMID:14633630   PMID:14637161  
PMID:14645231   PMID:14657385   PMID:14668351   PMID:14697265   PMID:14706620   PMID:14747574   PMID:14752167   PMID:14753456   PMID:14999066   PMID:15007175   PMID:15026410   PMID:15050367  
PMID:15055597   PMID:15082172   PMID:15084583   PMID:15090539   PMID:15126640   PMID:15133046   PMID:15133048   PMID:15145944   PMID:15146195   PMID:15161660   PMID:15163699   PMID:15170227  
PMID:15173173   PMID:15176439   PMID:15194501   PMID:15208260   PMID:15215178   PMID:15229245   PMID:15262264   PMID:15262998   PMID:15286374   PMID:15301538   PMID:15351724   PMID:15354287  
PMID:15448157   PMID:15451062   PMID:15459186   PMID:15467011   PMID:15489334   PMID:15494440   PMID:15509552   PMID:15514463   PMID:15528202   PMID:15530652   PMID:15539455   PMID:15539564  
PMID:15542685   PMID:15582152   PMID:15596141   PMID:15607951   PMID:15615717   PMID:15632154   PMID:15632159   PMID:15661974   PMID:15670611   PMID:15670743   PMID:15671025   PMID:15694261  
PMID:15706401   PMID:15709746   PMID:15753097   PMID:15767405   PMID:15782199   PMID:15800202   PMID:15824101   PMID:15827140   PMID:15837581   PMID:15846375   PMID:15851519   PMID:15862314  
PMID:15888663   PMID:15890277   PMID:15893468   PMID:15911347   PMID:15917101   PMID:15917252   PMID:15933194   PMID:15936714   PMID:15950943   PMID:15951190   PMID:15958749   PMID:15962001  
PMID:15970215   PMID:16023105   PMID:16029203   PMID:16084105   PMID:16120605   PMID:16135751   PMID:16141072   PMID:16141073   PMID:16157591   PMID:16160162   PMID:16177294   PMID:16198494  
PMID:16219759   PMID:16239348   PMID:16253245   PMID:16254249   PMID:16258172   PMID:16272297   PMID:16278084   PMID:16282497   PMID:16294306   PMID:16314415   PMID:16339028   PMID:16343423  
PMID:16386707   PMID:16441239   PMID:16467153   PMID:16480953   PMID:16492732   PMID:16517717   PMID:16519879   PMID:16537534   PMID:16547418   PMID:16554307   PMID:16569635   PMID:16574930  
PMID:16602821   PMID:16621165   PMID:16632309   PMID:16707568   PMID:16730679   PMID:16731968   PMID:16738485   PMID:16751368   PMID:16787422   PMID:16825571   PMID:16843609   PMID:16844683  
PMID:16866364   PMID:16908519   PMID:16912302   PMID:16934221   PMID:16935263   PMID:16940522   PMID:16942751   PMID:16945105   PMID:16952355   PMID:17056541   PMID:17062642   PMID:17084974  
PMID:17098996   PMID:17106625   PMID:17121821   PMID:17131403   PMID:17135402   PMID:17144900   PMID:17157195   PMID:17165097   PMID:17223707   PMID:17241158   PMID:17244617   PMID:17245436  
PMID:17245437   PMID:17251426   PMID:17270731   PMID:17292334   PMID:17304577   PMID:17320038   PMID:17334982   PMID:17337056   PMID:17360589   PMID:17379700   PMID:17388948   PMID:17405937  
PMID:17420473   PMID:17433806   PMID:17443816   PMID:17446686   PMID:17462540   PMID:17468101   PMID:17485546   PMID:17494993   PMID:17498663   PMID:17504807   PMID:17510630   PMID:17531449  
PMID:17569776   PMID:17570349   PMID:17573247   PMID:17573534   PMID:17611634   PMID:17612503   PMID:17618696   PMID:17626637   PMID:17635996   PMID:17697940   PMID:17703189   PMID:17709374  
PMID:17868300   PMID:17868659   PMID:17876822   PMID:17923484   PMID:17925394   PMID:17934213   PMID:17936697   PMID:17947689   PMID:17964827   PMID:17967411   PMID:17981146   PMID:17987132  
PMID:17989297   PMID:17997980   PMID:17999717   PMID:18023289   PMID:18042548   PMID:18066056   PMID:18068119   PMID:18073517   PMID:18088603   PMID:18155836   PMID:18175144   PMID:18205409  
PMID:18206163   PMID:18279314   PMID:18287559   PMID:18316717   PMID:18332141   PMID:18338400   PMID:18339329   PMID:18343219   PMID:18350378   PMID:18358791   PMID:18374587   PMID:18374666  
PMID:18400886   PMID:18416605   PMID:18419754   PMID:18431006   PMID:18443219   PMID:18462346   PMID:18473442   PMID:18490487   PMID:18498440   PMID:18514536   PMID:18562311   PMID:18566584  
PMID:18579743   PMID:18580573   PMID:18590772   PMID:18614678   PMID:18628989   PMID:18632556   PMID:18638557   PMID:18667494   PMID:18674620   PMID:18680312   PMID:18687339   PMID:18706894  
PMID:18722532   PMID:18797300   PMID:18804434   PMID:18808201   PMID:18809465   PMID:18815152   PMID:18826953   PMID:18831069   PMID:18834644   PMID:18835352   PMID:18840415   PMID:18973680  
PMID:19000842   PMID:19038218   PMID:19046329   PMID:19052217   PMID:19053276   PMID:19056496   PMID:19064990   PMID:19073920   PMID:19074151   PMID:19098904   PMID:19100703   PMID:19129193  
PMID:19143847   PMID:19164910   PMID:19173221   PMID:19204074   PMID:19209230   PMID:19223590   PMID:19233277   PMID:19242475   PMID:19243016   PMID:19249347   PMID:19283723   PMID:19285121  
PMID:19286300   PMID:19381258   PMID:19385058   PMID:19400950   PMID:19457070   PMID:19477226   PMID:19479969   PMID:19523487   PMID:19524041   PMID:19568430   PMID:19597535   PMID:19618915  
PMID:19655812   PMID:19664595   PMID:19666958   PMID:19675240   PMID:19685161   PMID:19700753   PMID:19703931   PMID:19709627   PMID:19710140   PMID:19720066   PMID:19738901   PMID:19747526  
PMID:19748890   PMID:19760599   PMID:19766283   PMID:19766638   PMID:19786843   PMID:19805070   PMID:19806224   PMID:19823766   PMID:19834742   PMID:19843586   PMID:19844576   PMID:19846876  
PMID:19850936   PMID:19854187   PMID:19855845   PMID:19888917   PMID:19910576   PMID:19940127   PMID:20007469   PMID:20040362   PMID:20048341   PMID:20075202   PMID:20085368   PMID:20086009  
PMID:20098419   PMID:20106973   PMID:20110469   PMID:20133875   PMID:20138835   PMID:20145049   PMID:20161712   PMID:20206606   PMID:20219645   PMID:20221436   PMID:20238136   PMID:20345906  
PMID:20356832   PMID:20394048   PMID:20395435   PMID:20445063   PMID:20460128   PMID:20472884   PMID:20541558   PMID:20599662   PMID:20610764   PMID:20615969   PMID:20626348   PMID:20649983  
PMID:20660771   PMID:20670217   PMID:20679345   PMID:20679477   PMID:20703260   PMID:20717837   PMID:20808809   PMID:20818492   PMID:20876210   PMID:20878768   PMID:20926176   PMID:20930564  
PMID:20957200   PMID:20970434   PMID:21041683   PMID:21060848   PMID:21083616   PMID:21123371   PMID:21144827   PMID:21156803   PMID:21193014   PMID:21195746   PMID:21209925   PMID:21212268  
PMID:21212283   PMID:21214263   PMID:21267068   PMID:21277044   PMID:21277354   PMID:21323366   PMID:21334441   PMID:21335237   PMID:21350487   PMID:21357423   PMID:21385869   PMID:21406608  
PMID:21432853   PMID:21439331   PMID:21441896   PMID:21441913   PMID:21453198   PMID:21466851   PMID:21478263   PMID:21483752   PMID:21555356   PMID:21559407   PMID:21586567   PMID:21619885  
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PMID:22093825   PMID:22100763   PMID:22114562   PMID:22144895   PMID:22163178   PMID:22184125   PMID:22216002   PMID:22222374   PMID:22252492   PMID:22262833   PMID:22285492   PMID:22307640  
PMID:22331873   PMID:22363722   PMID:22398286   PMID:22428057   PMID:22447932   PMID:22449963   PMID:22493452   PMID:22511770   PMID:22529900   PMID:22536327   PMID:22537845   PMID:22542184  
PMID:22586108   PMID:22619325   PMID:22648512   PMID:22654104   PMID:22679554   PMID:22687393   PMID:22705206   PMID:22711839   PMID:22743555   PMID:22745483   PMID:22762267   PMID:22770220  
PMID:22772447   PMID:22789566   PMID:22820466   PMID:22854022   PMID:22860039   PMID:22866057   PMID:22889724   PMID:22910907   PMID:22912582   PMID:22915801   PMID:22922482   PMID:22927985  
PMID:22929230   PMID:22930754   PMID:22948149   PMID:22956830   PMID:22987112   PMID:23002439   PMID:23022479   PMID:23061439   PMID:23072804   PMID:23121447   PMID:23132868   PMID:23133383  
PMID:23139828   PMID:23145988   PMID:23238082   PMID:23256626   PMID:23283973   PMID:23290724   PMID:23335053   PMID:23345215   PMID:23349890   PMID:23386614   PMID:23395905   PMID:23407955  
PMID:23415788   PMID:23481568   PMID:23487467   PMID:23580200   PMID:23593266   PMID:23637596   PMID:23650394   PMID:23680490   PMID:23729591   PMID:23761404   PMID:23764837   PMID:23770331  
PMID:23787699   PMID:23792955   PMID:23805846   PMID:23808898   PMID:23811055   PMID:23825952   PMID:23831375   PMID:23843953   PMID:23851597   PMID:23892077   PMID:23903654   PMID:23936187  
PMID:23940658   PMID:23949728   PMID:23959875   PMID:23966386   PMID:24000807   PMID:24012003   PMID:24012669   PMID:24027305   PMID:24038599   PMID:24040215   PMID:24086135   PMID:24117858  
PMID:24133259   PMID:24143866   PMID:24145514   PMID:24204258   PMID:24225951   PMID:24244171   PMID:24247244   PMID:24280226   PMID:24307586   PMID:24312586   PMID:24329154   PMID:24338008  
PMID:24352451   PMID:24352465   PMID:24430187   PMID:24431459   PMID:24461016   PMID:24493590   PMID:24497115   PMID:24554723   PMID:24574409   PMID:24596090   PMID:24604355   PMID:24608126  
PMID:24631389   PMID:24667414   PMID:24685176   PMID:24714645   PMID:24752288   PMID:24766164   PMID:24810941   PMID:24952961   PMID:24965601   PMID:25005024   PMID:25034251   PMID:25058617  
PMID:25139744   PMID:25202268   PMID:25242137   PMID:25416551   PMID:25426519   PMID:25447819   PMID:25490046   PMID:25502554   PMID:25510416   PMID:25517431   PMID:25539913   PMID:25572394  
PMID:25584902   PMID:25654651   PMID:25658480   PMID:25671600   PMID:25673720   PMID:25692227   PMID:25695140   PMID:25710374   PMID:25810062   PMID:25810548   PMID:25862412   PMID:25972546  
PMID:25989742   PMID:26024859   PMID:26033638   PMID:26152722   PMID:26155834   PMID:26159734   PMID:26165121   PMID:26175152   PMID:26224882   PMID:26250617   PMID:26256540   PMID:26287631  
PMID:26295309   PMID:26298321   PMID:26299705   PMID:26423957   PMID:26490404   PMID:26500295   PMID:26500296   PMID:26553874   PMID:26589795   PMID:26608316   PMID:26627256   PMID:26710111  
PMID:26713717   PMID:26721882   PMID:26857744   PMID:26864450   PMID:26873446   PMID:26926995   PMID:26949218   PMID:27128441   PMID:27208175   PMID:27226369   PMID:27227882   PMID:27317661  
PMID:27325697   PMID:27325698   PMID:27327609   PMID:27365298   PMID:27440899   PMID:27447728   PMID:27463540   PMID:27501152   PMID:27535221   PMID:27550517   PMID:27563063   PMID:27591261  
PMID:27629560   PMID:27629715   PMID:27641601   PMID:27689697   PMID:27726110   PMID:27818203   PMID:27849581   PMID:27880767   PMID:27891071   PMID:27936017   PMID:27973593   PMID:27975168  
PMID:27982059   PMID:28178353   PMID:28207746   PMID:28229331   PMID:28527237   PMID:28532839   PMID:28545141   PMID:28630311   PMID:28669732   PMID:28701513   PMID:28736314   PMID:28739602  
PMID:28760925   PMID:28821618   PMID:28827331   PMID:28842420   PMID:28842494   PMID:28851903   PMID:28855681   PMID:28874781   PMID:28924012   PMID:28945221   PMID:29070671   PMID:29111324  
PMID:29220360   PMID:29265373   PMID:29337365   PMID:29409004   PMID:29569342   PMID:29574582   PMID:29577883   PMID:29700113   PMID:29700330   PMID:29705776   PMID:29748616   PMID:29791485  
PMID:29846863   PMID:30054538   PMID:30068389   PMID:30128651   PMID:30174115   PMID:30235355   PMID:30275016   PMID:30355631   PMID:30359282   PMID:30513342   PMID:30550785   PMID:30729399  
PMID:30914754   PMID:30956132   PMID:31041657   PMID:31147460   PMID:31161647   PMID:31189938   PMID:31291644   PMID:31371412   PMID:31511544   PMID:31624071   PMID:31666632   PMID:31726043  
PMID:31950499   PMID:31985492   PMID:31987501   PMID:32012886   PMID:32107004   PMID:32111742   PMID:32165692   PMID:32317725   PMID:32325033   PMID:32394432   PMID:32473880   PMID:32560809  
PMID:32561641   PMID:32673372   PMID:32738196   PMID:32829029   PMID:32845931   PMID:32861834   PMID:32875355   PMID:32895288   PMID:32898162   PMID:32959170   PMID:32985542   PMID:33137126  
PMID:33481951   PMID:33547547   PMID:33662396   PMID:33713980   PMID:34052264   PMID:34065232   PMID:34102212   PMID:34321999   PMID:34358614   PMID:34502545   PMID:34572594   PMID:34710372  
PMID:34810220   PMID:34847154   PMID:35000151   PMID:35027047   PMID:35970974   PMID:36266319   PMID:36417873   PMID:36449254   PMID:36576715   PMID:36707620   PMID:37099550   PMID:37142655  
PMID:37616303   PMID:37636075   PMID:37802314   PMID:37941487   PMID:37976283   PMID:39237588   PMID:39284839   PMID:39381753  


Genomics

Comparative Map Data
Prnp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392131,751,848 - 131,780,356 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2131,751,848 - 131,780,349 (+)EnsemblGRCm39 Ensembl
GRCm382131,909,928 - 131,938,436 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2131,909,928 - 131,938,429 (+)EnsemblGRCm38mm10GRCm38
MGSCv372131,735,664 - 131,764,167 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362131,601,398 - 131,629,868 (+)NCBIMGSCv36mm8
Celera2133,143,177 - 133,164,079 (+)NCBICelera
Cytogenetic Map2F2NCBI
cM Map264.07NCBI
PRNP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38204,686,456 - 4,701,588 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl204,686,350 - 4,701,590 (+)EnsemblGRCh38hg38GRCh38
GRCh37204,667,102 - 4,682,234 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36204,614,797 - 4,630,234 (+)NCBINCBI36Build 36hg18NCBI36
Build 34204,615,068 - 4,630,233NCBI
Celera204,736,512 - 4,751,948 (+)NCBICelera
Cytogenetic Map20p13NCBI
HuRef204,620,194 - 4,635,632 (+)NCBIHuRef
CHM1_1204,667,528 - 4,682,967 (+)NCBICHM1_1
T2T-CHM13v2.0204,725,692 - 4,740,800 (+)NCBIT2T-CHM13v2.0
Prnp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83139,639,076 - 139,654,420 (+)NCBIGRCr8
mRatBN7.23119,186,073 - 119,201,513 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3119,177,485 - 119,203,937 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3123,090,082 - 123,105,437 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03131,676,802 - 131,692,409 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03129,346,188 - 129,361,543 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03124,515,917 - 124,531,320 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3124,515,978 - 124,531,316 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03131,009,974 - 131,025,370 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43119,676,137 - 119,691,507 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13119,581,709 - 119,597,080 (+)NCBI
Celera3117,986,209 - 118,001,394 (+)NCBICelera
Cytogenetic Map3q36NCBI
Prnp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541515,442,313 - 15,454,644 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541515,442,313 - 15,454,644 (+)NCBIChiLan1.0ChiLan1.0
PRNP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2215,641,025 - 5,656,375 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1205,637,965 - 5,653,199 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0204,713,616 - 4,728,847 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1204,523,141 - 4,525,522 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl204,523,155 - 4,523,916 (+)Ensemblpanpan1.1panPan2
PRNP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12416,845,224 - 16,862,319 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2416,846,207 - 16,859,815 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2416,670,727 - 16,671,500 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02417,263,379 - 17,280,460 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2417,263,381 - 17,280,378 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12416,859,351 - 16,860,124 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02416,965,836 - 16,966,609 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02417,299,279 - 17,300,052 (-)NCBIUU_Cfam_GSD_1.0
Prnp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640165,673,463 - 165,687,259 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648514,104,831 - 14,118,629 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648514,104,829 - 14,118,614 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRNP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1713,694,190 - 13,705,124 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11713,694,195 - 13,705,126 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21714,656,638 - 14,667,625 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRNP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1233,368,020 - 33,384,556 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl233,369,629 - 33,370,366 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607111,150,240 - 11,165,879 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prnp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247415,785,158 - 5,802,162 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247415,785,139 - 5,802,162 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:481
Count of miRNA genes:353
Interacting mature miRNAs:408
Transcripts:ENSMUST00000091288, ENSMUST00000142070
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301905Lgth2_mbody length 2 (mouse)Not determined2111173704145173821Mouse
1302033Nsv1_mNeuroadapted Sindbis viral RNA level 1 (mouse)Not determined2111623386145623526Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
13506763Tbvq1_mtrabecular bone volume QTL 1 (mouse)2126041920135441920Mouse
11039520Ltpr2h_mLeishmania tropica response 2h (mouse)2112212746146213005Mouse
11039521Ltpr2g_mLeishmania tropica response 2g (mouse)2115212857149212994Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118589253160611165Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118589253160611165Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294230345154241920Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118589253160611165Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118589253160611165Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
1302071Fembrs1_mfemur breaking strength 1 (mouse)Not determined2100942930134943090Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2110916118154354667Mouse
1302203Gvhd3_mgraft-versus host disease 3 (mouse)Not determined2100942930134943090Mouse
1300793Pcfm2_mperiosteal circumference and femur length 2 (mouse)Not determined2111173704145173821Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284013198148667470Mouse
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2123937311157937424Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
1301031Bdln3_mbody length 3 (mouse)Not determined2127664019161664118Mouse
1301029T2dm3_mtype 2 diabetes mellitus 3 (mouse)Not determined2114288075132714157Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102630345159941920Mouse
1301295Prdt1_mprion disease incubation time 1 (mouse)Not determined2116077623150077741Mouse
1301294Hrtfm5_mheart failure modifier 5 (mouse)Not determined2122883015156883131Mouse
11038696Ltpr2f_mLeishmania tropica response 2f (mouse)2115212857149212994Mouse
1301330Tbbmd2_mtotal body bone mineral density 2 (mouse)Not determined2100942930134943090Mouse
1301201Chab1_mcholesterol absorption 1 (mouse)Not determined2111551028145551163Mouse
11038699Ltpr2b_mLeishmania tropica response 2b (mouse)2112212746146213005Mouse
11038700Ltpr2a_mLeishmania tropica response 2a (mouse)2112212746146213005Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
1301087Bbaa15_mB.burgdorferi-associated arthritis 15 (mouse)Not determined2110489658144489807Mouse
1301825Pbrgcsf1_mperipheral blood stem cell response to granulocyte colony stimulating factor 1 (mouse)Not determined2106233580140233729Mouse
4141802Ignpq1_mIgA nephropathy QTL 1 (mouse)Not determined2100824060134824269Mouse
1558990Skmw9_mskeletal muscle weight 9 (mouse)Not determined2111173704145173821Mouse
1301066Otx2m2_morthodenticle homolog 2 (Drosophila) modifier 2 (mouse)Not determined2123231973148700377Mouse
1558989Gnf4_mgrowth and fatness 4 (mouse)Not determined2128173704132714157Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284013198148522175Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124441920168241920Mouse
1301755Hrq1_mheart rate quantitative locus 1 (mouse)Not determined2111173704145173821Mouse
13207586Mwmlpt2_mMorris water maze latency to platform, training, 2 (mouse)2131616184139216184Mouse
1302143Bwq5_mbody weight (mouse)Not determined2127664019161664118Mouse
12880427V25Dq3_mvitamin D inactive form serum level QTL 3 (mouse)2129341920163341920Mouse
13207590Mwmlpa2_mMorris water maze latency to platform, all, 2 (mouse)2131616184139616184Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
1558881Ses7_msalmonella enteritidis susceptibility 7 (mouse)Not determined2116306330150306474Mouse
10043875Bw25_mbody weight QTL 25 (mouse)Not determined2107255676141255676Mouse
1300712El2_mepilepsy 2 (mouse)Not determined2122207146142532135Mouse

Markers in Region
M13685  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382131,937,668 - 131,937,759UniSTSGRCm38
MGSCv372131,763,404 - 131,763,495UniSTSGRCm37
Celera2133,163,316 - 133,163,407UniSTS
Cytogenetic Map2F2UniSTS
cM Map275.0UniSTS
Whitehead/MRC_RH21638.82UniSTS
AI325101  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382131,938,116 - 131,938,251UniSTSGRCm38
MGSCv372131,763,852 - 131,763,987UniSTSGRCm37
Celera2133,163,764 - 133,163,899UniSTS
Cytogenetic Map2F2UniSTS
cM Map275.0UniSTS
Whitehead/MRC_RH21637.72UniSTS
AA960666  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382131,937,216 - 131,937,411UniSTSGRCm38
MGSCv372131,762,952 - 131,763,147UniSTSGRCm37
Celera2133,162,864 - 133,163,059UniSTS
Cytogenetic Map2F2UniSTS
cM Map275.0UniSTS
Whitehead/MRC_RH21636.69UniSTS
PMC125625P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382131,936,430 - 131,937,194UniSTSGRCm38
MGSCv372131,762,166 - 131,762,930UniSTSGRCm37
Celera2133,162,078 - 133,162,842UniSTS
Cytogenetic Map2F2UniSTS
cM Map275.0UniSTS
PMC136595P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382131,936,447 - 131,936,999UniSTSGRCm38
MGSCv372131,762,183 - 131,762,735UniSTSGRCm37
Celera2133,162,095 - 133,162,647UniSTS
Cytogenetic Map2F2UniSTS
cM Map275.0UniSTS
PMC136859P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382131,936,715 - 131,937,192UniSTSGRCm38
MGSCv372131,762,451 - 131,762,928UniSTSGRCm37
Celera2133,162,363 - 133,162,840UniSTS
Cytogenetic Map2F2UniSTS
cM Map275.0UniSTS
UniSTS:224477  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382131,937,312 - 131,937,474UniSTSGRCm38
MGSCv372131,763,048 - 131,763,210UniSTSGRCm37
Celera2133,162,960 - 133,163,122UniSTS
Cytogenetic Map2F2UniSTS
cM Map275.0UniSTS
px-35d12  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4A5UniSTS
Cytogenetic Map1E3-E4UniSTS
Cytogenetic Map2F2UniSTS
Cytogenetic Map12C3UniSTS
cM Map275.0UniSTS
px-36f4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3B-DUniSTS
Cytogenetic Map12C3UniSTS
Cytogenetic Map1E3-E4UniSTS
Cytogenetic Map2F2UniSTS
Cytogenetic Map4C6UniSTS
cM Map275.0UniSTS
px-50g7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3F1UniSTS
Cytogenetic Map7A3UniSTS
Cytogenetic Map7B5UniSTS
Cytogenetic Map13A3.2UniSTS
Cytogenetic Map2C2UniSTS
Cytogenetic Map3B-DUniSTS
Cytogenetic Map17B1UniSTS
Cytogenetic Map7A2UniSTS
Cytogenetic Map12EUniSTS
Cytogenetic Map4C6UniSTS
Cytogenetic Map4C1UniSTS
Cytogenetic Map18CUniSTS
Cytogenetic Map12C3UniSTS
Cytogenetic Map6G1UniSTS
Cytogenetic Map8A1.1UniSTS
Cytogenetic Map16A1UniSTS
Cytogenetic MapXDUniSTS
Cytogenetic Map2F2UniSTS
Cytogenetic Map17A3.3UniSTS
Cytogenetic Map1DUniSTS
Cytogenetic Map2G3UniSTS
Cytogenetic Map9A1UniSTS
Cytogenetic Map4A5UniSTS
Cytogenetic Map4D2.2UniSTS
cM Map74.0UniSTS
cM Map1718.88UniSTS
cM Map241.25UniSTS
cM Map727.0UniSTS
cM Map342.1UniSTS
cM Map275.0UniSTS
cM Map153.6UniSTS
cM Map91.0UniSTS
px-58e10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4A5UniSTS
Cytogenetic Map12C3UniSTS
Cytogenetic Map6G1UniSTS
Cytogenetic Map1E3-E4UniSTS
Cytogenetic Map3B-DUniSTS
Cytogenetic Map2F2UniSTS
Cytogenetic Map19C3UniSTS
Cytogenetic Map4C6UniSTS
cM Map1942.0UniSTS
cM Map275.0UniSTS
Prnp  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382131,936,430 - 131,936,718UniSTSGRCm38
MGSCv372131,763,197 - 131,763,425UniSTSGRCm37
Celera2133,162,078 - 133,162,366UniSTS
Cytogenetic Map2F2UniSTS
cM Map275.0UniSTS
cM Map275.0UniSTS
Prnp  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382131,937,461 - 131,937,689UniSTSGRCm38
MGSCv372131,763,197 - 131,763,425UniSTSGRCm37
Celera2133,163,109 - 133,163,337UniSTS
Cytogenetic Map2F2UniSTS
cM Map275.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001278256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK148061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK158908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL833794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV361844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC032085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BK064102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BK064103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BK064104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ044630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK622972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU637930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M13685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M18070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M18071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M30384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U29186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U29187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U52821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X79931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X79932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X83612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X83613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y17510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000091288   ⟹   ENSMUSP00000088833
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2131,751,848 - 131,780,349 (+)Ensembl
GRCm38.p6 Ensembl2131,909,928 - 131,938,429 (+)Ensembl
Ensembl Acc Id: ENSMUST00000142070
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2131,751,862 - 131,760,078 (+)Ensembl
GRCm38.p6 Ensembl2131,909,942 - 131,918,158 (+)Ensembl
RefSeq Acc Id: NM_001278256   ⟹   NP_001265185
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392131,751,848 - 131,780,356 (+)NCBI
GRCm382131,909,928 - 131,938,436 (+)NCBI
Celera2133,143,177 - 133,164,084 (+)NCBI
Sequence:
RefSeq Acc Id: NM_011170   ⟹   NP_035300
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392131,751,848 - 131,780,356 (+)NCBI
GRCm382131,909,928 - 131,938,436 (+)NCBI
MGSCv372131,735,664 - 131,764,167 (+)RGD
Celera2133,143,177 - 133,164,084 (+)NCBI
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_035300   ⟸   NM_011170
- Peptide Label: precursor
- UniProtKB: P04925 (UniProtKB/Swiss-Prot),   Q4FJQ7 (UniProtKB/TrEMBL),   Q3TZI7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001265185   ⟸   NM_001278256
- Peptide Label: precursor
- UniProtKB: P04925 (UniProtKB/Swiss-Prot),   Q4FJQ7 (UniProtKB/TrEMBL),   Q3TZI7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000088833   ⟸   ENSMUST00000091288
Protein Domains
Prion/Doppel protein beta-ribbon

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04925-F1-model_v2 AlphaFold P04925 1-254 view protein structure

Promoters
RGD ID:6832145
Promoter ID:MM_KWN:31824
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000104932,   NM_011170,   OTTMUST00000035253,   OTTMUST00000035254,   OTTMUST00000035260,   UC008MLZ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362131,734,671 - 131,735,812 (+)MPROMDB
RGD ID:6878824
Promoter ID:EPDNEW_M2863
Type:initiation region
Name:Prnp_1
Description:Mus musculus prion protein , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382131,909,968 - 131,910,028EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97769 AgrOrtholog
Ensembl Genes ENSMUSG00000079037 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000091288 ENTREZGENE
  ENSMUST00000091288.13 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.790.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Prion UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prion/Doppel_b-ribbon_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prion/Doppel_prot_b-ribbon_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prion_N_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19122 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97769 ENTREZGENE
NCBI Gene 19122 ENTREZGENE
PANTHER DOPPEL PRION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAJOR PRION PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Prion UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prion_bPrPp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prnp PhenoGen
PRINTS PRION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PRION_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRION_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PRP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54098 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P04925 ENTREZGENE, UniProtKB/Swiss-Prot
  Q3TZI7 ENTREZGENE, UniProtKB/TrEMBL
  Q3UBH0_MOUSE UniProtKB/TrEMBL
  Q3UF68_MOUSE UniProtKB/TrEMBL
  Q3UG89_MOUSE UniProtKB/TrEMBL
  Q4FJQ7 ENTREZGENE, UniProtKB/TrEMBL