Prkg2 (protein kinase, cGMP-dependent, type II) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Prkg2 (protein kinase, cGMP-dependent, type II) Mus musculus
Analyze
Symbol: Prkg2
Name: protein kinase, cGMP-dependent, type II
RGD ID: 11149
MGI Page MGI
Description: Enables cGMP-dependent protein kinase activity. Involved in cellular hypotonic response and negative regulation of cell volume. Acts upstream of or within circadian regulation of gene expression. Located in plasma membrane. Is expressed in brain; limb segment; lung; and small intestine. Human ortholog(s) of this gene implicated in acromesomelic dysplasia 4 and spondylometaphyseal dysplasia. Orthologous to human PRKG2 (protein kinase cGMP-dependent 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW212535; cGK 2; cGK-; cGK-II; cGK2; CGKII; cGMP-dependent protein kinase 2; cGMP-dependent protein kinase II; MGC130517; Prk; Prkgr2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39599,077,632 - 99,185,042 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl599,077,632 - 99,185,210 (-)EnsemblGRCm39 Ensembl
GRCm38598,929,773 - 99,037,375 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl598,929,773 - 99,037,351 (-)EnsemblGRCm38mm10GRCm38
MGSCv37599,358,792 - 99,466,098 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36599,171,570 - 99,277,381 (-)NCBIMGSCv36mm8
Celera596,252,278 - 96,360,518 (-)NCBICelera
Cytogenetic Map5E3NCBI
cM Map548.35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
4-nitrophenol  (EXP)
6-propyl-2-thiouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
aldehydo-D-glucose  (EXP)
aluminium atom  (EXP)
aluminium(0)  (EXP)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
atrazine  (ISO)
Azoxymethane  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chromium(6+)  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
crocidolite asbestos  (EXP,ISO)
D-glucose  (EXP)
dexamethasone  (EXP)
dextran sulfate  (EXP)
diclofenac  (EXP)
diethylstilbestrol  (ISO)
ethanol  (EXP)
fenvalerate  (ISO)
FR900359  (ISO)
glucose  (EXP)
glyphosate  (ISO)
ketoconazole  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (EXP)
methylphenidate  (EXP)
N,N-diethyl-m-toluamide  (ISO)
okadaic acid  (ISO)
palytoxin  (EXP)
perfluorohexanesulfonic acid  (EXP)
permethrin  (ISO)
phenobarbital  (EXP)
pirinixic acid  (EXP)
potassium dichromate  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sotorasib  (ISO)
streptozocin  (ISO)
tadalafil  (EXP)
titanium dioxide  (EXP)
trametinib  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (EXP)
triptonide  (EXP)
trovafloxacin  (EXP)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
venlafaxine hydrochloride  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cyclic GMP-dependent protein kinase II is a molecular switch from proliferation to hypertrophic differentiation of chondrocytes. Chikuda H, etal., Genes Dev. 2004 Oct 1;18(19):2418-29. doi: 10.1101/gad.1224204.
2. Cloning, expression, and in situ localization of rat intestinal cGMP-dependent protein kinase II. Jarchau T, etal., Proc Natl Acad Sci U S A 1994 Sep 27;91(20):9426-30.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Phenotypic characterization of the Komeda miniature rat Ishikawa, an animal model of dwarfism caused by a mutation in Prkg2. Tsuchida A, etal., Comp Med. 2008 Dec;58(6):560-7.
Additional References at PubMed
PMID:7498513   PMID:8137944   PMID:8514791   PMID:8953039   PMID:9788971   PMID:9870937   PMID:10349636   PMID:10454212   PMID:10531334   PMID:10694248   PMID:11042159   PMID:11076861  
PMID:11217851   PMID:12054676   PMID:12193576   PMID:12477932   PMID:12725729   PMID:12764134   PMID:15590741   PMID:15610182   PMID:15905169   PMID:16141072   PMID:16141073   PMID:16210344  
PMID:16829211   PMID:17954614   PMID:18031684   PMID:18551195   PMID:18656450   PMID:18799693   PMID:19154345   PMID:19282289   PMID:20057151   PMID:20498039   PMID:21177494   PMID:21267068  
PMID:21347269   PMID:21677750   PMID:21873635   PMID:22556146   PMID:23103773   PMID:23545413   PMID:24270408   PMID:24442122   PMID:24752151   PMID:25480791   PMID:25713349   PMID:25978317  
PMID:26921296   PMID:27421896   PMID:27998725   PMID:29914933   PMID:30529950   PMID:31509448   PMID:32270922   PMID:32360667   PMID:34126178   PMID:35188962   PMID:36371651   PMID:38533975  


Genomics

Comparative Map Data
Prkg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39599,077,632 - 99,185,042 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl599,077,632 - 99,185,210 (-)EnsemblGRCm39 Ensembl
GRCm38598,929,773 - 99,037,375 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl598,929,773 - 99,037,351 (-)EnsemblGRCm38mm10GRCm38
MGSCv37599,358,792 - 99,466,098 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36599,171,570 - 99,277,381 (-)NCBIMGSCv36mm8
Celera596,252,278 - 96,360,518 (-)NCBICelera
Cytogenetic Map5E3NCBI
cM Map548.35NCBI
PRKG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38481,087,370 - 81,217,836 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl481,087,370 - 81,215,222 (-)EnsemblGRCh38hg38GRCh38
GRCh37482,008,524 - 82,136,376 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36482,228,861 - 82,345,239 (-)NCBINCBI36Build 36hg18NCBI36
Build 34482,367,015 - 82,483,394NCBI
Celera479,302,549 - 79,418,932 (-)NCBICelera
Cytogenetic Map4q21.21NCBI
HuRef477,753,401 - 77,870,008 (-)NCBIHuRef
CHM1_1481,986,323 - 82,102,706 (-)NCBICHM1_1
T2T-CHM13v2.0484,417,063 - 84,547,534 (-)NCBIT2T-CHM13v2.0
Prkg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81410,864,020 - 10,972,617 (+)NCBIGRCr8
mRatBN7.21410,559,882 - 10,668,479 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1410,559,882 - 10,666,888 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1410,540,037 - 10,640,477 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01411,839,852 - 11,940,298 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01410,529,813 - 10,630,458 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01412,217,121 - 12,313,616 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1412,218,553 - 12,315,229 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01412,159,378 - 12,255,994 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41411,888,101 - 12,005,547 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11411,888,100 - 12,005,547 (+)NCBI
Celera1410,666,687 - 10,755,836 (+)NCBICelera
Cytogenetic Map14p22NCBI
Prkg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554335,286,153 - 5,491,924 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554335,286,594 - 5,387,571 (-)NCBIChiLan1.0ChiLan1.0
PRKG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2348,855,500 - 48,982,421 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1449,044,222 - 49,172,066 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0442,987,217 - 43,114,993 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1448,836,953 - 48,960,383 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl448,836,953 - 48,960,383 (+)Ensemblpanpan1.1panPan2
PRKG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1325,266,435 - 5,365,396 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl325,266,442 - 5,365,396 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3236,517,409 - 36,617,588 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0325,294,681 - 5,395,076 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl325,294,693 - 5,395,085 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1325,324,348 - 5,424,902 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0325,231,256 - 5,331,589 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03234,635,113 - 34,735,693 (+)NCBIUU_Cfam_GSD_1.0
Prkg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244052856,966,547 - 7,070,004 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936749900,208 - 991,891 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8136,755,469 - 136,852,906 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18136,754,698 - 136,854,589 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28146,048,858 - 146,148,011 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRKG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1729,511,796 - 29,629,943 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl729,511,380 - 29,618,330 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660378,011,684 - 8,129,346 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247579,798,808 - 9,906,517 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247579,799,777 - 9,904,825 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prkg2
6119 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:836
Count of miRNA genes:493
Interacting mature miRNAs:567
Transcripts:ENSMUST00000031277, ENSMUST00000160765, ENSMUST00000161490, ENSMUST00000162147, ENSMUST00000162619
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
10045978Tir10_mtrypanosome infection response 10 (mouse)Not determined598019649114021986Mouse
1301399Cpfd3_mcerebellum pattern fissures (mouse)Not determined587386871121387065Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
1357725Eae39_mexperimental allergic encephalomyelitis 39 (mouse)Not determined589418876118864028Mouse
10045972Tir5_mtrypanosome infection response 5 (mouse)Not determined563705442104387065Mouse
1300993Hycdc_mhypercapnic duty cycle (mouse)Not determined590561006124561151Mouse
1301126Bwem1_mbody weight day 30 males 1 (mouse)Not determined587386871121387065Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined32133234100777931Mouse
1300659Pcd8ts1_mp-glycoprotein positive CD8 T cell subset 1 (mouse)Not determined597021753131021986Mouse
1301042Elmaz1_melevated maze behavior 1 (mouse)Not determined598019649116876624Mouse
1301691Cdcs10_mcytokine deficiency colitis susceptibility 10 (mouse)Not determined576280786110280917Mouse
10402486Dipa1_mdrug induced psychomotor activation 1 (mouse)Not determined595465549129465722Mouse
11041665Lmr24_mleishmaniasis resistance 24 (mouse)552694462107321041Mouse
10043958Chldq12_mcholesterol and HDL QTL 12 (mouse)Not determined587386871121387065Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
12738422Lfibq15_mliver fibrosis QTL 15 (mouse)599150794100196474Mouse
1301419Cypr3_mcytokine production 3 (mouse)Not determined581019649115019803Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
10043993Hbnr10_mHeligmosomoides bakeri nematode resistance 10 (mouse)Not determined572418876106419011Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
10401246Bglu13_mblood glucose level 13 (mouse)Not determined579539640113539786Mouse
4141438Skmw13_mskeletal muscle weight 13 (mouse)Not determined576190263110190479Mouse
1301713Dbsty2_mdiabesity 2 (mouse)Not determined576445064110445225Mouse
1301457Cfsw2_mcystic fibrosis survival to weaning 2 (mouse)Not determined590561006124561151Mouse
11041899Lmr24a_mleishmaniasis resistance 24a (mouse)552694462107321041Mouse
10401245Bglu18_mblood glucose level 18 (mouse)Not determined582838468116838597Mouse
1301974Chab7_mcholesterol absorption 7 (mouse)Not determined595233214129233330Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
1300931Cocrb6_mcocaine related behavior 6 (mouse)Not determined576445064110445225Mouse
4142317Rgcs1_mretinal ganglion cell susceptible 1 (mouse)Not determined55388334108762627Mouse
1300801Drb2_mdopamine receptor binding 2 (mouse)Not determined587386871121387065Mouse
1301829Thyls2_mthymic lymphoma susceptibility 2 (mouse)Not determined576445064110445225Mouse
9587780Afw16_mabdominal fat weight QTL 16 (mouse)Not determined592830166126830285Mouse
1357644Egrd1_mearly growth rate, direct effect 1 (mouse)Not determined595434580129434786Mouse
1300940Actd3_mactivity-distance traveled 3 (mouse)Not determined596320385130320533Mouse
12904740M1fscn2_mmodifier 1 of Fscn2 (mouse)566529661100529661Mouse
10755524Mono1_mmonocyte differential 1 (mouse)580849259114849259Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
1558774Lith17_mlithogenic gene 17 (mouse)Not determined595465549129465722Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575315348120018629Mouse
12904739M2fscn2_mmodifier 2 of FSCN2 (mouse)566529661100529661Mouse
1301243Bmd2_mbone mineral density 2 (mouse)Not determined555388334100455525Mouse
1300986Hdlq2_mHDL QTL 2 (mouse)Not determined576280786110280917Mouse
1301858Smdq1_msegregation of mitochondrial DNA QTL 1 (mouse)Not determined597021753131021986Mouse
11049562Lmr24f_mleishmaniasis resistance 24f (mouse)590320962124321041Mouse
13464249Ahl16_mage related hearing loss, early onset 16 (mouse)576445064110445225Mouse
13464244Ahl19_mage related hearing loss, early onset 19 (mouse)595465549129465722Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589418876124238239Mouse
13464241Ahl18_mage related hearing loss, early onset 18 (mouse)587386871121387065Mouse
4141505Chlq14_mcirculating hormone level QTL 14 (mouse)Not determined576280786110280917Mouse
13464242Ahl17_mage related hearing loss, early onset 17 (mouse)582838468116838597Mouse

Markers in Region
AW212535  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38598,931,507 - 98,931,633UniSTSGRCm38
MGSCv37599,360,526 - 99,360,652UniSTSGRCm37
Celera596,254,012 - 96,254,138UniSTS
Cytogenetic Map5E3UniSTS
cM Map553.0UniSTS
Whitehead/MRC_RH51175.56UniSTS
RH118292  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38598,939,423 - 98,939,594UniSTSGRCm38
MGSCv37599,368,442 - 99,368,613UniSTSGRCm37
Celera596,262,500 - 96,262,671UniSTS
Cytogenetic Map5E3UniSTS
cM Map553.0UniSTS
Whitehead/MRC_RH51175.35UniSTS
Whitehead/MRC_RH51175.56UniSTS
Prkg2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37599,453,423 - 99,453,490UniSTSGRCm37
Celera596,347,867 - 96,347,934UniSTS
Cytogenetic Map5E3UniSTS
cM Map553.0UniSTS
cM Map553.0UniSTS
Prkg2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38599,024,404 - 99,024,471UniSTSGRCm38
MGSCv37599,453,423 - 99,453,490UniSTSGRCm37
Celera596,347,867 - 96,347,934UniSTS
Cytogenetic Map5E3UniSTS
cM Map553.0UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000031277   ⟹   ENSMUSP00000031277
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl599,079,579 - 99,184,894 (-)Ensembl
GRCm38.p6 Ensembl598,931,720 - 99,037,035 (-)Ensembl
Ensembl Acc Id: ENSMUST00000160765
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl599,095,252 - 99,114,615 (-)Ensembl
GRCm38.p6 Ensembl598,947,393 - 98,966,756 (-)Ensembl
Ensembl Acc Id: ENSMUST00000161490   ⟹   ENSMUSP00000124963
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl599,077,632 - 99,185,210 (-)Ensembl
GRCm38.p6 Ensembl598,929,773 - 99,037,351 (-)Ensembl
Ensembl Acc Id: ENSMUST00000162147   ⟹   ENSMUSP00000143708
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl599,079,127 - 99,091,693 (-)Ensembl
GRCm38.p6 Ensembl598,931,268 - 98,943,834 (-)Ensembl
Ensembl Acc Id: ENSMUST00000162619   ⟹   ENSMUSP00000142743
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl599,079,127 - 99,091,691 (-)Ensembl
GRCm38.p6 Ensembl598,931,268 - 98,943,832 (-)Ensembl
RefSeq Acc Id: NM_008926   ⟹   NP_032952
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39599,077,632 - 99,184,938 (-)NCBI
GRCm38598,929,773 - 99,037,079 (-)NCBI
MGSCv37599,358,792 - 99,466,098 (-)RGD
Celera596,252,278 - 96,360,518 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006534820   ⟹   XP_006534883
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39599,117,846 - 99,185,042 (-)NCBI
GRCm38598,969,987 - 99,037,375 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006534821   ⟹   XP_006534884
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39599,079,115 - 99,119,816 (-)NCBI
GRCm38598,931,256 - 98,971,957 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036164897   ⟹   XP_036020790
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39599,077,632 - 99,185,042 (-)NCBI
Sequence:
RefSeq Acc Id: NP_032952   ⟸   NM_008926
- UniProtKB: Q8C4R2 (UniProtKB/TrEMBL),   Q8CAH8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006534884   ⟸   XM_006534821
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006534883   ⟸   XM_006534820
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSMUSP00000031277   ⟸   ENSMUST00000031277
Ensembl Acc Id: ENSMUSP00000142743   ⟸   ENSMUST00000162619
Ensembl Acc Id: ENSMUSP00000143708   ⟸   ENSMUST00000162147
Ensembl Acc Id: ENSMUSP00000124963   ⟸   ENSMUST00000161490
RefSeq Acc Id: XP_036020790   ⟸   XM_036164897
- Peptide Label: isoform X1
- UniProtKB: Q8C4R2 (UniProtKB/TrEMBL)
Protein Domains
AGC-kinase C-terminal   Cyclic nucleotide-binding   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61410-F1-model_v2 AlphaFold Q61410 1-762 view protein structure

Promoters
RGD ID:6887252
Promoter ID:EPDNEW_M7077
Type:initiation region
Name:Prkg2_1
Description:Mus musculus protein kinase, cGMP-dependent, type II , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38598,943,828 - 98,943,888EPDNEW
RGD ID:6838108
Promoter ID:MM_KWN:43031
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1
Transcripts:OTTMUST00000083842,   OTTMUST00000083844
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36599,372,609 - 99,373,109 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:108173 AgrOrtholog
Ensembl Genes ENSMUSG00000029334 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000161490 ENTREZGENE
Gene3D-CATH 2.60.120.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro AGC-kinase_C UniProtKB/Swiss-Prot
  cGMP_dep_kinase UniProtKB/Swiss-Prot
  cNMP-bd-like UniProtKB/Swiss-Prot
  cNMP-bd_CS UniProtKB/Swiss-Prot
  cNMP-bd_dom UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  RmlC-like_jellyroll UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  STKc_cGK UniProtKB/Swiss-Prot
MGD MGI:108173 ENTREZGENE
NCBI Gene 19092 ENTREZGENE
PANTHER CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE UniProtKB/Swiss-Prot
  PTHR24353:SF24 UniProtKB/Swiss-Prot
Pfam cNMP_binding UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
PhenoGen Prkg2 PhenoGen
PIRSF cGMP-dep_kinase UniProtKB/Swiss-Prot
PRINTS CGMPKINASE UniProtKB/Swiss-Prot
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot
  CNMP_BINDING_1 UniProtKB/Swiss-Prot
  CNMP_BINDING_2 UniProtKB/Swiss-Prot
  CNMP_BINDING_3 UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
SMART cNMP UniProtKB/Swiss-Prot
  S_TK_X UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51206 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A0A0G2JEE8_MOUSE UniProtKB/TrEMBL
  E9QPH0_MOUSE UniProtKB/TrEMBL
  KGP2_MOUSE UniProtKB/Swiss-Prot
  Q3TMJ2_MOUSE UniProtKB/TrEMBL
  Q61410 ENTREZGENE
  Q8C4R2 ENTREZGENE, UniProtKB/TrEMBL
  Q8CAH8 ENTREZGENE, UniProtKB/TrEMBL