Pik3r1 (phosphoinositide-3-kinase regulatory subunit 1) - Rat Genome Database

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Gene: Pik3r1 (phosphoinositide-3-kinase regulatory subunit 1) Mus musculus
Symbol: Pik3r1
Name: phosphoinositide-3-kinase regulatory subunit 1
RGD ID: 11103
Description: Enables several functions, including insulin receptor substrate binding activity; kinase regulator activity; and phosphatidylinositol 3-kinase regulatory subunit binding activity. Involved in several processes, including negative regulation of stress fiber assembly; positive regulation of cellular component organization; and transmembrane receptor protein tyrosine kinase signaling pathway. Acts upstream of or within several processes, including apoptotic signaling pathway; negative regulation of osteoclast differentiation; and positive regulation of tumor necrosis factor production. Located in several cellular components, including cell-cell junction; cis-Golgi network; and perinuclear endoplasmic reticulum membrane. Part of protein-containing complex. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and integumental system. Used to study SHORT syndrome and X-linked agammaglobulinemia. Human ortholog(s) of this gene implicated in several diseases, including SHORT syndrome; agammaglobulinemia 7; astroblastoma; endometrial cancer (multiple); and immunodeficiency 36. Orthologous to human PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AA414921; C530050K14; p50; p50alpha; p55; p55alpha; p85; p85alpha; phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; phosphatidylinositol 3-kinase regulatory subunit alpha; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); PI; PI3-kinase regulatory subunit alpha; PI3-kinase subunit p85-alpha; PI3K; PI3K regulatory subunit alpha; ptdIns-3-kinase regulatory subunit alpha; ptdIns-3-kinase regulatory subunit p85-alpha
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3913101,817,269 - 101,904,725 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13101,817,071 - 101,904,725 (-)EnsemblGRCm39 Ensembl
GRCm3813101,680,761 - 101,768,217 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13101,680,563 - 101,768,217 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713102,450,716 - 102,538,172 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613102,781,018 - 102,792,904 (-)NCBIMGSCv36mm8
Celera13105,285,857 - 105,373,612 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1353.92NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,5-hexanedione  (EXP)
2-butoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-nitrophenol  (EXP)
4-tert-butylphenol  (ISO)
9-cis-retinoic acid  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
anthocyanin  (ISO)
antimonite  (ISO)
arecoline  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
atazanavir sulfate  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (ISO)
bilirubin IXalpha  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (EXP)
bromobenzene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
capsaicin  (EXP)
capsazepine  (EXP)
carbamazepine  (ISO)
carbon nanotube  (EXP)
celastrol  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlorogenic acid  (EXP)
chromium atom  (EXP)
ciguatoxin CTX1B  (EXP)
cis-caffeic acid  (EXP)
cisplatin  (ISO)
clobetasol  (EXP)
cobalt dichloride  (ISO)
coenzyme Q10  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
daunorubicin  (ISO)
deoxycholic acid  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenz[a,h]anthracene  (EXP)
diclofenac  (EXP,ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
emodin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
eugenol  (EXP,ISO)
ferulic acid  (EXP)
folic acid  (EXP,ISO)
fonofos  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
furan  (ISO)
Garcinol  (ISO)
gedunin  (ISO)
geldanamycin  (ISO)
geraniol  (ISO)
glucose  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
gold atom  (EXP)
gold(0)  (EXP)
hesperidin  (ISO)
HU-308  (ISO)
hydrazines  (EXP)
hydrogen cyanide  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
linsidomine  (EXP)
lipopolysaccharide  (ISO)
LY294002  (EXP,ISO)
maculosin  (EXP)
melatonin  (EXP)
melphalan  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP)
methidathion  (EXP)
methotrexate  (EXP)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
mevinphos  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naringin  (EXP)
nefazodone  (ISO)
Neferine  (ISO)
nickel atom  (EXP)
nickel dichloride  (EXP)
Nonylphenol  (ISO)
obeticholic acid  (ISO)
olanzapine  (EXP)
ozone  (EXP,ISO)
paeoniflorin  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
procyanidin B1  (ISO)
propiconazole  (EXP)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quercitrin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (EXP)
rivastigmine  (ISO)
rotenone  (ISO)
ruthenium red  (EXP)
SB 431542  (ISO)
selenium atom  (EXP)
silicon dioxide  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
sirolimus  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
streptozocin  (EXP,ISO)
succimer  (EXP)
tamoxifen  (EXP)
taraxasterol  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
thiazolidinediones  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trans-caffeic acid  (EXP)
trans-cinnamic acid  (EXP)
tremolite asbestos  (EXP)
trichostatin A  (ISO)
triclosan  (EXP)
triptonide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
tungsten  (EXP)
tunicamycin  (EXP)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
wortmannin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
B cell differentiation  (IMP)
cellular response to fatty acid  (ISO)
cellular response to insulin stimulus  (IDA,ISO)
cellular response to UV  (IGI,IMP)
extrinsic apoptotic signaling pathway via death domain receptors  (IGI,IMP)
glucose metabolic process  (ISO)
growth hormone receptor signaling pathway  (ISO)
insulin receptor signaling pathway  (IBA,IDA,IMP,ISO)
insulin-like growth factor receptor signaling pathway  (IDA,IMP,ISO)
intracellular glucose homeostasis  (IDA)
intrinsic apoptotic signaling pathway in response to DNA damage  (IGI,IMP)
myeloid leukocyte migration  (IGI)
negative regulation of apoptotic process  (IDA,ISO)
negative regulation of blood pressure  (ISO)
negative regulation of cell adhesion  (IDA)
negative regulation of cell-cell adhesion  (ISO)
negative regulation of cell-matrix adhesion  (IGI)
negative regulation of heart rate  (ISO)
negative regulation of muscle cell apoptotic process  (ISO)
negative regulation of osteoclast differentiation  (IGI)
negative regulation of proteolysis  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of stress fiber assembly  (IDA)
osteoclast differentiation  (IGI)
phosphatidylinositol 3-kinase signaling  (ISO)
phosphatidylinositol phosphate biosynthetic process  (IBA)
positive regulation of cell migration  (ISO)
positive regulation of endoplasmic reticulum unfolded protein response  (ISO)
positive regulation of filopodium assembly  (IDA)
positive regulation of focal adhesion disassembly  (IDA)
positive regulation of gene expression  (ISO)
positive regulation of lamellipodium assembly  (IDA)
positive regulation of leukocyte migration  (IGI)
positive regulation of myoblast differentiation  (ISO)
positive regulation of protein import into nucleus  (IMP,ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of RNA splicing  (ISO)
positive regulation of synapse assembly  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IMP,ISO)
positive regulation of tumor necrosis factor production  (IMP)
protein import into nucleus  (IMP)
protein phosphorylation  (IDA)
protein stabilization  (ISO)
protein transport  (IEA)
regulation of insulin receptor signaling pathway  (IGI)
regulation of phosphatidylinositol 3-kinase activity  (IBA,ISO)
regulation of protein localization to plasma membrane  (IDA)
regulation of stress fiber assembly  (IMP)
response to amino acid  (ISO)
response to cAMP  (ISO)
response to dexamethasone  (ISO)
response to endoplasmic reticulum stress  (IDA,ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to fatty acid  (ISO)
response to fructose  (ISO)
response to glucocorticoid  (ISO)
response to growth factor  (ISO)
response to insulin  (ISO)
response to iron(II) ion  (ISO)
response to nutrient  (ISO)
response to progesterone  (ISO)
response to testosterone  (ISO)
response to xenobiotic stimulus  (ISO)
response to yeast  (ISO)
signal transduction  (IEA)
transcription by RNA polymerase II  (IMP)

Molecular Pathway Annotations     Click to see Annotation Detail View
acute myeloid leukemia pathway  (IEA)
aldosterone signaling pathway  (IEA)
apoptotic cell death pathway  (IEA)
B cell receptor signaling pathway  (IEA)
ceramide signaling pathway  (IEA)
Chagas disease pathway  (IEA)
chronic myeloid leukemia pathway  (IEA)
colorectal cancer pathway  (IEA)
E-cadherin signaling pathway  (ISO)
endometrial cancer pathway  (IEA)
Entamoebiasis pathway  (IEA)
ephrin - ephrin receptor bidirectional signaling axis  (ISO)
epidermal growth factor/neuregulin signaling pathway  (IEA,ISO)
erythropoietin signaling pathway  (ISO)
FasL mediated signaling pathway  (ISO)
Fc epsilon receptor mediated signaling pathway  (ISO)
fibroblast growth factor signaling pathway  (ISO)
glioma pathway  (IEA)
granulocyte-macrophage colony-stimulating factor signaling pathway  (ISO)
Hedgehog signaling pathway  (ISO)
hepatitis C pathway  (IEA)
influenza A pathway  (IEA)
insulin signaling pathway  (IEA,ISO)
insulin-like growth factor signaling pathway  (ISO)
interleukin-1 signaling pathway  (ISO)
interleukin-2 signaling pathway  (ISO)
interleukin-23 signaling pathway  (ISO)
interleukin-3 signaling pathway  (ISO)
interleukin-4 signaling pathway  (ISO)
interleukin-5 signaling pathway  (ISO)
interleukin-6 signaling pathway  (ISO)
Jak-Stat signaling pathway  (IEA)
measles pathway  (IEA)
melanoma pathway  (IEA)
mTOR signaling pathway  (IEA)
N-cadherin signaling pathway  (ISO)
neurotrophic factor signaling pathway  (IEA)
non-small cell lung carcinoma pathway  (IEA)
nuclear factor kappa B signaling pathway  (ISO)
pancreatic cancer pathway  (IEA)
phosphatidylinositol 3-kinase class I signaling pathway  (ISO)
phosphatidylinositol 3-kinase signaling pathway  (IEA)
phosphatidylinositol 3-kinase-Akt signaling pathway  (ISO)
phosphoinositide metabolic pathway  (ISO)
platelet-derived growth factor signaling pathway  (ISO)
prostate cancer pathway  (IEA)
Reelin signaling pathway  (ISO,TAS)
renal cell carcinoma pathway  (IEA)
scatter factor/hepatocyte growth factor signaling pathway  (ISO)
small cell lung carcinoma pathway  (IEA)
T cell receptor signaling pathway  (IEA)
Toll-like receptor signaling pathway  (IEA)
toxoplasmosis pathway  (IEA)
Trail mediated signaling pathway  (ISO)
type 2 diabetes mellitus pathway  (IEA)
type II interferon signaling pathway  (ISO)
vascular endothelial growth factor signaling pathway  (IEA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell differentiation  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal brown adipose tissue morphology  (IAGP)
abnormal epididymal fat pad morphology  (IAGP)
abnormal erythropoiesis  (IEA)
abnormal fat cell morphology  (IAGP)
abnormal fat pad morphology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal retina cone cell morphology  (IAGP)
abnormal ribbon synapse morphology  (IAGP)
abnormal synapse morphology  (IAGP)
arrested B cell differentiation  (IAGP)
chylous ascites  (IAGP)
decreased adipocyte glucose uptake  (IAGP)
decreased B cell number  (IAGP)
decreased B cell proliferation  (IAGP)
decreased B-1 B cell number  (IEA)
decreased B-1a cell number  (IEA)
decreased B-1b cell number  (IEA)
decreased B-2 B cell number  (IEA)
decreased b-wave amplitude  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased heart weight  (IAGP)
decreased immature B cell number  (IAGP)
decreased insulin secretion  (IAGP)
decreased lung tumor incidence  (IAGP)
decreased mature B cell number  (IAGP)
decreased NK T cell number  (IEA)
decreased pre-B cell number  (IAGP)
decreased pro-B cell number  (IAGP)
decreased subcutaneous adipose tissue amount  (IAGP)
decreased triglyceride level  (IAGP)
decreased white fat cell size  (IAGP)
dystrophic cardiac calcinosis  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
hepatic necrosis  (IAGP)
hyperglycemia  (IAGP)
hypoglycemia  (IAGP)
impaired glucose tolerance  (IAGP)
improved glucose tolerance  (IAGP)
increased adipocyte glucose uptake  (IAGP)
increased B cell apoptosis  (IAGP)
increased B-1b cell number  (IEA)
increased body fat mass  (IAGP)
increased body weight  (IAGP)
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number  (IEA)
increased CD8-positive, alpha-beta memory T cell number  (IEA)
increased circulating insulin level  (IAGP)
increased circulating insulin-like growth factor I level  (IAGP)
increased insulin sensitivity  (IAGP)
increased lung tumor incidence  (IAGP)
increased muscle cell glucose uptake  (IAGP)
increased pro-B cell number  (IAGP)
increased skeletal muscle fiber size  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
insulin resistance  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lipodystrophy  (IAGP)
no abnormal phenotype detected  (IAGP)
pancreatic islet hyperplasia  (IAGP)
perinatal lethality, complete penetrance  (IEA)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
retina cone cell degeneration  (IAGP)
small myocardial fiber  (IAGP)

References - curated
# Reference Title Reference Citation
1. Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action. Barroso I, etal., PLoS Biol. 2003 Oct;1(1):E20. Epub 2003 Oct 13.
2. Met, metastasis, motility and more. Birchmeier C, etal., Nat Rev Mol Cell Biol. 2003 Dec;4(12):915-25.
3. MicroRNA-542-3p Suppresses Tumor Cell Invasion via Targeting AKT Pathway in Human Astrocytoma. Cai J, etal., J Biol Chem. 2015 Oct 9;290(41):24678-88. doi: 10.1074/jbc.M115.649004. Epub 2015 Aug 18.
4. Integrated genomic characterization of endometrial carcinoma. Cancer Genome Atlas Research Network, etal., Nature. 2013 May 2;497(7447):67-73. doi: 10.1038/nature12113.
5. High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability. Cheung LW, etal., Cancer Discov. 2011 Jul;1(2):170-85. doi: 10.1158/2159-8290.CD-11-0039. Epub 2011 Jun 7.
6. EGF-ERBB signalling: towards the systems level. Citri A and Yarden Y, Nat Rev Mol Cell Biol. 2006 Jul;7(7):505-16.
7. Tissue- and fibre-specific modifications of insulin-signalling molecules in cardiac and skeletal muscle of diabetic rats. Ekladous D, etal., Clin Exp Pharmacol Physiol. 2008 Aug;35(8):971-8. Epub 2008 Apr 21.
8. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Engelman JA, etal., Nat Rev Genet. 2006 Aug;7(8):606-19.
9. Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice. Fukao T, etal., Nat Immunol 2002 Mar;3(3):295-304.
10. The Met tyrosine kinase receptor in development and cancer. Gentile A, etal., Cancer Metastasis Rev. 2008 Mar;27(1):85-94.
11. A comprehensive analysis of transcript signatures of the phosphatidylinositol-3 kinase/protein kinase B signal-transduction pathway in prostate cancer. Hellwinkel OJ, etal., BJU Int. 2008 Jun;101(11):1454-60. Epub 2008 Mar 11.
12. Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. Hirsch E, etal., J Endocrinol. 2007 Aug;194(2):243-56.
13. MicroRNA-Related Polymorphisms in PI3K/Akt/mTOR Pathway Genes Are Predictive of Limited-Disease Small Cell Lung Cancer Treatment Outcomes. Jiang W, etal., Biomed Res Int. 2017;2017:6501385. doi: 10.1155/2017/6501385. Epub 2017 Feb 9.
14. Activation of eNOS in rat portal hypertensive gastric mucosa is mediated by TNF-alpha via the PI 3-kinase-Akt signaling pathway. Kawanaka H, etal., Hepatology. 2002 Feb;35(2):393-402.
15. Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse. Kerouz NJ, etal., J Clin Invest. 1997 Dec 15;100(12):3164-72.
16. Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development. Khamzina L, etal., Gastroenterology 2003 Aug;125(2):572-85.
17. Protein kinase C-delta mediates neuronal apoptosis in the retinas of diabetic rats via the Akt signaling pathway. Kim YH, etal., Diabetes. 2008 Aug;57(8):2181-90. Epub 2008 Apr 28.
18. LncRNA MALAT1 mediates proliferation of LPS treated-articular chondrocytes by targeting the miR-146a-PI3K/Akt/mTOR axis. Li H, etal., Life Sci. 2020 Aug 1;254:116801. doi: 10.1016/j.lfs.2019.116801. Epub 2019 Aug 28.
19. Oroxin B Induces Apoptosis by Down-Regulating MicroRNA-221 Resulting in the Inactivation of the PTEN/PI3K/AKT Pathway in Liver Cancer. Li N, etal., Molecules. 2019 Nov 30;24(23). pii: molecules24234384. doi: 10.3390/molecules24234384.
20. PIK3R1 negatively regulates the epithelial-mesenchymal transition and stem-like phenotype of renal cancer cells through the AKT/GSK3ß/CTNNB1 signaling pathway. Lin Y, etal., Sci Rep. 2015 Mar 11;5:8997. doi: 10.1038/srep08997.
21. Genetic variability in the insulin signalling pathway may contribute to the risk of late onset Alzheimer's disease. Liolitsa D, etal., J Neurol Neurosurg Psychiatry. 2002 Sep;73(3):261-6.
22. Hepatic ischemia-reperfusion induces insulin resistance via down-regulation during the early steps in insulin signaling in rats. Liu C, etal., Transplant Proc. 2008 Dec;40(10):3330-4.
23. Phosphatidylinositol 3-kinase/Akt signaling stimulates colonic mucosal cell survival during aging. Majumdar AP and Du J, Am J Physiol Gastrointest Liver Physiol. 2006 Jan;290(1):G49-55. Epub 2005 Aug 25.
24. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
25. MGDs mouse GO annotations MGD data from the GO Consortium
27. Rapamycin inhibits multiple stages of c-Neu/ErbB2 induced tumor progression in a transgenic mouse model of HER2-positive breast cancer. Mosley JD, etal., Mol Cancer Ther. 2007 Aug;6(8):2188-97.
28. Analysis of expression profile of gene encoding proteins of signal cascades activated by insulin-like growth factors in colorectal cancer. Nowakowska-Zajdel E, etal., Int J Immunopathol Pharmacol. 2011 Jul-Sep;24(3):781-7.
29. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
30. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
31. Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle. Patti ME, etal., Diabetes. 1999 Aug;48(8):1562-71.
32. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
33. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
34. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
35. Differential reelin-induced enhancement of NMDA and AMPA receptor activity in the adult hippocampus. Qiu S, etal., J Neurosci. 2006 Dec 13;26(50):12943-55.
36. Mouse MP Annotation Import Pipeline RGD automated import pipeline
37. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
38. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
39. Insulin resistance in human preeclamptic placenta is mediated by serine phosphorylation of insulin receptor substrate-1 and -2. Scioscia M, etal., J Clin Endocrinol Metab. 2006 Feb;91(2):709-17. Epub 2005 Dec 6.
40. Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase. Suzuki H, etal., Science 1999 Jan 15;283(5400):390-2.
41. The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance. Taniguchi CM, etal., Mol Cell Biol. 2007 Apr;27(8):2830-40. Epub 2007 Feb 5.
42. Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Terauchi Y, etal., Nat Genet 1999 Feb;21(2):230-5.
43. PIK3R1 (p85a) is somatically mutated at high frequency in primary endometrial cancer. Urick ME, etal., Cancer Res. 2011 Jun 15;71(12):4061-7. doi: 10.1158/0008-5472.CAN-11-0549. Epub 2011 Apr 8.
44. Survival kinase genes present prognostic significance in glioblastoma. Varghese RT, etal., Oncotarget. 2016 Mar 4. doi: 10.18632/oncotarget.7917.
45. Gene expression profiling of lung adenocarcinoma in Xuanwei, China. Wu H, etal., Eur J Cancer Prev. 2016 Nov;25(6):508-17. doi: 10.1097/CEJ.0000000000000214.
46. Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma in Rats by Inhibiting PI3K-AKT-NF-κB Pathway. Zhang CL, etal., Int J Biol Sci. 2015 Apr 25;11(6):643-51. doi: 10.7150/ijbs.10785. eCollection 2015.
47. Reduced cardiotropic response to insulin in spontaneously hypertensive rats: role of peroxisome proliferator-activated receptor-gamma-initiated signaling. Zhang H, etal., J Hypertens. 2008 Mar;26(3):560-9.
48. Chronic blockade of phosphatidylinositol 3-kinase in the nucleus tractus solitarii is prohypertensive in the spontaneously hypertensive rat. Zubcevic J, etal., Hypertension. 2009 Jan;53(1):97-103. Epub 2008 Nov 17.
Additional References at PubMed
PMID:1370584   PMID:1372092   PMID:1375946   PMID:1849460   PMID:7504175   PMID:7505116   PMID:7522165   PMID:7534300   PMID:7542745   PMID:7685197   PMID:7698770   PMID:7983060  
PMID:7997267   PMID:8054357   PMID:8402898   PMID:8524290   PMID:8557661   PMID:8702385   PMID:8706703   PMID:8754810   PMID:8828042   PMID:8889548   PMID:8916957   PMID:8921377  
PMID:8947469   PMID:9013636   PMID:9062339   PMID:9115297   PMID:9174058   PMID:9312046   PMID:9624169   PMID:9852579   PMID:9888855   PMID:9890970   PMID:10330148   PMID:10349636  
PMID:10373493   PMID:10391678   PMID:10486198   PMID:10521483   PMID:10620012   PMID:10633073   PMID:10644978   PMID:10646608   PMID:10679268   PMID:10681597   PMID:10725249   PMID:10783143  
PMID:10799548   PMID:10829070   PMID:10862698   PMID:10871282   PMID:10894496   PMID:10922068   PMID:10940298   PMID:10967104   PMID:10995764   PMID:11031258   PMID:11038173   PMID:11042159  
PMID:11062485   PMID:11076861   PMID:11163197   PMID:11217851   PMID:11406619   PMID:11526404   PMID:11544199   PMID:11591653   PMID:11711534   PMID:11756327   PMID:11781359   PMID:11784871  
PMID:11895767   PMID:11896055   PMID:12024020   PMID:12052866   PMID:12086468   PMID:12196526   PMID:12429725   PMID:12477932   PMID:12515821   PMID:12520002   PMID:12560232   PMID:12563258  
PMID:12588990   PMID:12595588   PMID:12623844   PMID:12649157   PMID:12679424   PMID:12700661   PMID:12761849   PMID:12783867   PMID:12808090   PMID:12870650   PMID:12882964   PMID:12904583  
PMID:14595115   PMID:14610044   PMID:14610273   PMID:14623341   PMID:14673165   PMID:14681479   PMID:14684612   PMID:14688330   PMID:14688354   PMID:14966267   PMID:14976048   PMID:15006698  
PMID:15020231   PMID:15039234   PMID:15102471   PMID:15169905   PMID:15180287   PMID:15183122   PMID:15192701   PMID:15226823   PMID:15249583   PMID:15322182   PMID:15331535   PMID:15351743  
PMID:15368367   PMID:15377662   PMID:15380067   PMID:15384044   PMID:15385169   PMID:15520044   PMID:15536084   PMID:15542585   PMID:15581361   PMID:15581362   PMID:15592455   PMID:15685168  
PMID:15741161   PMID:15767666   PMID:15769893   PMID:15791001   PMID:15793565   PMID:15817165   PMID:15821749   PMID:15887120   PMID:15896301   PMID:16005454   PMID:16006513   PMID:16036919  
PMID:16043515   PMID:16107612   PMID:16114097   PMID:16141072   PMID:16141073   PMID:16166093   PMID:16186103   PMID:16227599   PMID:16239435   PMID:16249387   PMID:16310342   PMID:16354682  
PMID:16375864   PMID:16380230   PMID:16380231   PMID:16449529   PMID:16455755   PMID:16467569   PMID:16503174   PMID:16514418   PMID:16602821   PMID:16625210   PMID:16636057   PMID:16670329  
PMID:16679292   PMID:16679293   PMID:16699071   PMID:16709832   PMID:16725108   PMID:16741926   PMID:16798720   PMID:16798838   PMID:16880210   PMID:16880400   PMID:16916926   PMID:16921024  
PMID:16981137   PMID:16990448   PMID:17014982   PMID:17024187   PMID:17053831   PMID:17071741   PMID:17164340   PMID:17187756   PMID:17215071   PMID:17237381   PMID:17242187   PMID:17322282  
PMID:17324588   PMID:17342361   PMID:17360811   PMID:17363744   PMID:17369456   PMID:17397400   PMID:17420256   PMID:17470792   PMID:17475862   PMID:17483298   PMID:17490618   PMID:17521884  
PMID:17535857   PMID:17554062   PMID:17574041   PMID:17606624   PMID:17646168   PMID:17666435   PMID:17682062   PMID:17698586   PMID:17724683   PMID:17846664   PMID:17901711   PMID:17934470  
PMID:17963723   PMID:17967808   PMID:17982262   PMID:17991742   PMID:18006275   PMID:18006698   PMID:18048492   PMID:18059474   PMID:18179858   PMID:18192285   PMID:18199538   PMID:18203667  
PMID:18287559   PMID:18294630   PMID:18296638   PMID:18303010   PMID:18322234   PMID:18328427   PMID:18339426   PMID:18346204   PMID:18376306   PMID:18382766   PMID:18387942   PMID:18388186  
PMID:18398001   PMID:18405384   PMID:18407828   PMID:18449193   PMID:18449947   PMID:18453570   PMID:18479958   PMID:18492954   PMID:18501893   PMID:18538520   PMID:18548087   PMID:18575225  
PMID:18596174   PMID:18621722   PMID:18624917   PMID:18636972   PMID:18675826   PMID:18704194   PMID:18769043   PMID:18769155   PMID:18782222   PMID:18799693   PMID:18809581   PMID:18927440  
PMID:18948408   PMID:18981154   PMID:18988856   PMID:19020099   PMID:19029981   PMID:19065634   PMID:19074768   PMID:19076776   PMID:19117013   PMID:19176357   PMID:19190753   PMID:19229869  
PMID:19270693   PMID:19289601   PMID:19290049   PMID:19376889   PMID:19401591   PMID:19420107   PMID:19500387   PMID:19501627   PMID:19509285   PMID:19521778   PMID:19541766   PMID:19556857  
PMID:19587782   PMID:19605683   PMID:19631775   PMID:19635806   PMID:19640849   PMID:19648963   PMID:19685158   PMID:19693771   PMID:19705443   PMID:19740326   PMID:19747164   PMID:19747165  
PMID:19790269   PMID:19811262   PMID:19819947   PMID:19855934   PMID:19917692   PMID:19939451   PMID:19952357   PMID:19962978   PMID:20007249   PMID:20011526   PMID:20018937   PMID:20060825  
PMID:20133944   PMID:20167705   PMID:20203102   PMID:20212113   PMID:20348923   PMID:20348926   PMID:20368346   PMID:20433747   PMID:20467438   PMID:20504929   PMID:20530665   PMID:20598684  
PMID:20616072   PMID:20665729   PMID:20668162   PMID:20697350   PMID:20705779   PMID:20713122   PMID:20804756   PMID:20826237   PMID:20855612   PMID:20857427   PMID:20930845   PMID:21037083  
PMID:21057544   PMID:21095008   PMID:21106690   PMID:21109194   PMID:21145830   PMID:21232086   PMID:21267068   PMID:21324896   PMID:21362552   PMID:21367821   PMID:21393858   PMID:21398281  
PMID:21442372   PMID:21461612   PMID:21466842   PMID:21496122   PMID:21595858   PMID:21677750   PMID:21689728   PMID:21725061   PMID:21730346   PMID:21731673   PMID:21785161   PMID:21788516  
PMID:21791431   PMID:21791602   PMID:21825134   PMID:21827948   PMID:21873635   PMID:21907926   PMID:21946561   PMID:21964322   PMID:22006022   PMID:22020336   PMID:22053215   PMID:22118415  
PMID:22154837   PMID:22187458   PMID:22187460   PMID:22238586   PMID:22272764   PMID:22274952   PMID:22291095   PMID:22297723   PMID:22315502   PMID:22323595   PMID:22342344   PMID:22378846  
PMID:22378847   PMID:22391413   PMID:22402124   PMID:22426621   PMID:22430739   PMID:22459179   PMID:22493067   PMID:22508063   PMID:22553040   PMID:22586681   PMID:22684007   PMID:22698915  
PMID:22727795   PMID:22806988   PMID:22879882   PMID:22897848   PMID:22998445   PMID:23077605   PMID:23082158   PMID:23109711   PMID:23143475   PMID:23145070   PMID:23247210   PMID:23291213  
PMID:23315073   PMID:23390317   PMID:23529017   PMID:23665174   PMID:23673657   PMID:23749170   PMID:23775122   PMID:23793062   PMID:23823479   PMID:23825606   PMID:23831514   PMID:23874604  
PMID:23874982   PMID:23968914   PMID:24012746   PMID:24022164   PMID:24036213   PMID:24058635   PMID:24113870   PMID:24129178   PMID:24266852   PMID:24294595   PMID:24315994   PMID:24327733  
PMID:24333443   PMID:24342610   PMID:24361011   PMID:24395790   PMID:24454942   PMID:24464560   PMID:24470255   PMID:24477292   PMID:24506665   PMID:24567360   PMID:24651434   PMID:24657164  
PMID:24658595   PMID:24698271   PMID:24752319   PMID:24825007   PMID:24856209   PMID:24859974   PMID:24881819   PMID:24902901   PMID:24932806   PMID:24944017   PMID:24952961   PMID:25004888  
PMID:25103499   PMID:25157163   PMID:25204429   PMID:25217619   PMID:25243123   PMID:25287161   PMID:25328665   PMID:25432021   PMID:25436971   PMID:25460003   PMID:25711660   PMID:25754093  
PMID:26002917   PMID:26037503   PMID:26115623   PMID:26163884   PMID:26278818   PMID:26297811   PMID:26303320   PMID:26372898   PMID:26458524   PMID:26565021   PMID:26657864   PMID:26719856  
PMID:26728565   PMID:26740176   PMID:26773505   PMID:26918608   PMID:26974159   PMID:27119228   PMID:27135603   PMID:27157990   PMID:27199286   PMID:27245220   PMID:27318131   PMID:27339033  
PMID:27482546   PMID:27522498   PMID:27697523   PMID:27708159   PMID:27799550   PMID:27884787   PMID:27897192   PMID:28292967   PMID:28408298   PMID:28493079   PMID:28615644   PMID:28630349  
PMID:28632845   PMID:28687614   PMID:28712865   PMID:28733636   PMID:29058721   PMID:29130119   PMID:29342370   PMID:29555819   PMID:29662076   PMID:29724723   PMID:29983910   PMID:29996100  
PMID:30429249   PMID:30667096   PMID:31107947   PMID:31260032   PMID:31267272   PMID:31420539   PMID:31577955   PMID:31848327   PMID:31924648   PMID:32290105   PMID:32325033   PMID:32439336  
PMID:32755576   PMID:32895527   PMID:33215443   PMID:33431871   PMID:33567274   PMID:33567340   PMID:34193412   PMID:34691235   PMID:35695427   PMID:36319097   PMID:36343340   PMID:36354735  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3913101,817,269 - 101,904,725 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13101,817,071 - 101,904,725 (-)EnsemblGRCm39 Ensembl
GRCm3813101,680,761 - 101,768,217 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13101,680,563 - 101,768,217 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713102,450,716 - 102,538,172 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613102,781,018 - 102,792,904 (-)NCBIMGSCv36mm8
Celera13105,285,857 - 105,373,612 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1353.92NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38568,215,756 - 68,301,821 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl568,215,740 - 68,301,821 (+)EnsemblGRCh38hg38GRCh38
GRCh37567,511,584 - 67,597,649 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36567,558,218 - 67,633,405 (+)NCBINCBI36Build 36hg18NCBI36
Build 34567,622,250 - 67,633,403NCBI
Celera564,520,829 - 64,597,175 (+)NCBICelera
Cytogenetic Map5q13.1NCBI
HuRef564,468,818 - 64,555,164 (+)NCBIHuRef
CHM1_1567,511,846 - 67,597,747 (+)NCBICHM1_1
T2T-CHM13v2.0569,037,982 - 69,124,117 (+)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2232,878,942 - 32,963,611 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl232,882,032 - 32,963,631 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx240,014,126 - 40,099,015 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0238,073,343 - 38,158,218 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0232,921,198 - 33,006,089 (-)NCBIRnor_WKY
Rnor_6.0231,742,326 - 31,826,882 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl231,745,088 - 31,826,867 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0250,891,225 - 50,965,217 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4232,602,673 - 32,675,350 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1232,523,041 - 32,595,719 (-)NCBI
Celera228,878,690 - 28,948,863 (-)NCBICelera
RH 3.4 Map2111.0RGD
Cytogenetic Map2q12NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554461,020,043 - 1,098,820 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554461,020,707 - 1,098,327 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.1547,268,477 - 47,350,960 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl547,267,286 - 47,350,960 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0545,701,219 - 45,786,652 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1253,447,802 - 53,527,563 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl253,448,286 - 53,524,970 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha250,408,936 - 50,489,628 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0253,951,256 - 54,032,010 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl253,960,673 - 54,031,993 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1251,011,708 - 51,092,420 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0251,791,194 - 51,871,863 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0252,678,736 - 52,759,442 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024407213192,252,011 - 192,336,736 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364801,188,183 - 1,273,537 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364801,188,408 - 1,273,210 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1646,511,521 - 46,523,609 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11646,434,757 - 46,523,626 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21650,135,837 - 50,148,434 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1464,321,296 - 64,406,188 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl464,321,078 - 64,406,519 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604913,008,003 - 13,093,192 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248151,289,997 - 1,369,610 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248151,290,106 - 1,376,961 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID

Predicted Target Of
Summary Value
Count of predictions:3087
Count of miRNA genes:737
Interacting mature miRNAs:988
Transcripts:ENSMUST00000035532, ENSMUST00000055518
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
4142314Tailaq3_mtail length adjusted QTL 3 (mouse)Not determined55720354112431103Mouse
4140959W10q17_mweight 10 weeks QTL 17 (mouse)Not determined55720354112431103Mouse
4141992W6q16_mweight 6 weeks QTL 16 (mouse)Not determined55720354112431103Mouse
4142241Tailq3_mtail length QTL 3 (mouse)Not determined55720354112431103Mouse
10402414Sgp5_mserum gp70 production 5 (mouse)Not determined1356470456105422186Mouse
1301593Heal8_mwound healing/regeneration 8 (mouse)Not determined1368053999102054119Mouse
14696726Kidrq3_mkidney weight, right QTL 3 (mouse)1368217066102217066Mouse
14747007Mancz11_mmandible centroid size 11 (mouse)1370111284104111284Mouse
4141266Mol3_mmodifier of LPS-response 3 (mouse)Not determined76132600112431103Mouse
12880414V125Dq10_mvitamin D active form serum level QTL 10 (mouse)1378036508112036508Mouse
10043997Bw40_mbody weight QTL 40 (mouse)Not determined1479239045113239162Mouse
10045623Heal18_mwound healing regeneration 18 (mouse)Not determined1379239045113239162Mouse
1558741Ses10_msalmonella enteritidis susceptibility 10 (mouse)Not determined1382739968116740106Mouse
4142465Pbwg17_mpostnatal body weight growth 17 (mouse)Not determined1383876060117876256Mouse
14700691Cisaq1_mcoxsackieviral infection serum ALT QTL 1 (mouse)1386148119120461536Mouse
4140995Fbtq6_mfemoral bone trait QTL 6 (mouse)Not determined1386341617120341758Mouse
4141728Egaq4_mearly growth adjusted QTL 4 (mouse)Not determined87901985112431103Mouse
1300939Hrtfm6_mheart failure modifier 6 (mouse)Not determined1391383692120883175Mouse
1300876Tanidd2_mtally ho associated non-insulin dependednt diabetes mellitus 2 (mouse)Not determined1391965303120883175Mouse
1301142Heal2_mwound healing/regeneration 2 (mouse)Not determined1393875267120883175Mouse
4142338Skmw18_mskeletal muscle weight 18 (mouse)Not determined1394528399120883175Mouse
1558763Gct9_mgranulosa cell tumorigenesis 9 (mouse)Not determined1395036824120883175Mouse
1357468Rplag_mreduced platelet aggregation (mouse)Not determined1395502130120883175Mouse
14746974Manh75_mmandible shape 75 (mouse)1399386647120883175Mouse
4141102Sod1m_msuperoxide dismutase 1, soluble, modifier (mouse)Not determined99739968110699911Mouse
12879496Fexq2_mfear expression QTL 2 (mouse)13100741519120883175Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3813101,684,683 - 101,684,766UniSTSGRCm38
MGSCv3713102,454,638 - 102,454,721UniSTSGRCm37
Celera13105,289,776 - 105,289,859UniSTS
Cytogenetic Map13D1UniSTS
cM Map1350.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3813101,757,350 - 101,757,489UniSTSGRCm38
MGSCv3713102,527,305 - 102,527,444UniSTSGRCm37
Celera13105,362,470 - 105,362,609UniSTS
Cytogenetic Map13D1UniSTS
cM Map1350.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3813101,684,676 - 101,684,859UniSTSGRCm38
MGSCv3713102,454,631 - 102,454,814UniSTSGRCm37
Celera13105,289,769 - 105,289,952UniSTS
Cytogenetic Map13D1UniSTS
cM Map1350.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3813101,683,944 - 101,684,067UniSTSGRCm38
MGSCv3713102,453,899 - 102,454,022UniSTSGRCm37
Celera13105,289,040 - 105,289,163UniSTS
Cytogenetic Map13D1UniSTS
cM Map1350.0UniSTS



Nucleotide Sequences
RefSeq Transcripts NM_001024955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001077495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006517569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006517570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC107663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC153139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI838690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK046259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK049798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB647657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM963795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY276314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB519962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF169061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M60651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U50413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U50414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000035532   ⟹   ENSMUSP00000047004
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13101,820,172 - 101,829,138 (-)Ensembl
GRCm38.p6 Ensembl13101,683,664 - 101,692,630 (-)Ensembl
RefSeq Acc Id: ENSMUST00000055518   ⟹   ENSMUSP00000056774
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13101,817,071 - 101,904,725 (-)Ensembl
GRCm38.p6 Ensembl13101,680,563 - 101,768,217 (-)Ensembl
RefSeq Acc Id: ENSMUST00000185701
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13101,837,957 - 101,838,612 (-)Ensembl
GRCm38.p6 Ensembl13101,701,449 - 101,702,104 (-)Ensembl
RefSeq Acc Id: ENSMUST00000185795   ⟹   ENSMUSP00000140312
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13101,825,548 - 101,831,108 (-)Ensembl
GRCm38.p6 Ensembl13101,689,040 - 101,694,600 (-)Ensembl
RefSeq Acc Id: ENSMUST00000187009   ⟹   ENSMUSP00000140256
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13101,824,090 - 101,829,084 (-)Ensembl
GRCm38.p6 Ensembl13101,687,582 - 101,692,576 (-)Ensembl
RefSeq Acc Id: ENSMUST00000189426
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13101,892,079 - 101,904,721 (-)Ensembl
GRCm38.p6 Ensembl13101,755,571 - 101,768,213 (-)Ensembl
RefSeq Acc Id: ENSMUST00000190171
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13101,826,643 - 101,828,851 (-)Ensembl
GRCm38.p6 Ensembl13101,690,135 - 101,692,343 (-)Ensembl
RefSeq Acc Id: NM_001024955   ⟹   NP_001020126
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm3913101,817,269 - 101,829,138 (-)NCBI
GRCm3813101,680,761 - 101,692,630 (-)NCBI
MGSCv3713102,450,716 - 102,538,172 (-)RGD
Celera13105,285,857 - 105,373,612 (-)RGD
RefSeq Acc Id: NM_001077495   ⟹   NP_001070963
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm3913101,817,269 - 101,904,725 (-)NCBI
GRCm3813101,680,761 - 101,768,217 (-)ENTREZGENE
MGSCv3713102,450,716 - 102,538,172 (-)RGD
Celera13105,285,857 - 105,373,612 (-)RGD
RefSeq Acc Id: XM_006517569   ⟹   XP_006517632
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm3913101,817,269 - 101,833,259 (-)NCBI
GRCm3813101,680,761 - 101,696,751 (-)NCBI
RefSeq Acc Id: XM_006517570   ⟹   XP_006517633
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm3913101,817,269 - 101,830,871 (-)NCBI
GRCm3813101,680,761 - 101,694,363 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001070963   ⟸   NM_001077495
- Peptide Label: isoform 2
- UniProtKB: Q8K3B3 (UniProtKB/Swiss-Prot),   P26450 (UniProtKB/Swiss-Prot),   Q3TP23 (UniProtKB/TrEMBL),   Q8C7P2 (UniProtKB/TrEMBL),   A0A8C6GDA3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001020126   ⟸   NM_001024955
- Peptide Label: isoform 1
- UniProtKB: Q3TP23 (UniProtKB/TrEMBL),   Q80UI5 (UniProtKB/TrEMBL),   Q8C7P2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006517632   ⟸   XM_006517569
- Peptide Label: isoform X1
- UniProtKB: A0A6P5QPP5 (UniProtKB/TrEMBL),   A0A8C6GC10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006517633   ⟸   XM_006517570
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000140312   ⟸   ENSMUST00000185795
RefSeq Acc Id: ENSMUSP00000047004   ⟸   ENSMUST00000035532
RefSeq Acc Id: ENSMUSP00000140256   ⟸   ENSMUST00000187009
RefSeq Acc Id: ENSMUSP00000056774   ⟸   ENSMUST00000055518
Protein Domains
Rho-GAP   SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P26450-F1-model_v2 AlphaFold P26450 1-724 view protein structure

RGD ID:8681194
Promoter ID:EPDNEW_M18628
Type:single initiation site
Description:Mus musculus phosphoinositide-3-kinase regulatory subunit 1 ,transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M18629  EPDNEW_M18630  
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm3813101,694,428 - 101,694,488EPDNEW
RGD ID:8681198
Promoter ID:EPDNEW_M18629
Type:initiation region
Description:Mus musculus phosphoinositide-3-kinase regulatory subunit 1 ,transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M18628  EPDNEW_M18630  
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm3813101,694,691 - 101,694,751EPDNEW
RGD ID:8681200
Promoter ID:EPDNEW_M18630
Type:initiation region
Description:Mus musculus phosphoinositide-3-kinase regulatory subunit 1 ,transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M18628  EPDNEW_M18629  
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm3813101,768,177 - 101,768,237EPDNEW
RGD ID:6847052
Promoter ID:MM_ACW:14426
SO ACC ID:SO:0000170
Tissues & Cell Lines:Liver
Mouse AssemblyChrPosition (strand)Source
MGSCv3613102,454,596 - 102,455,096 (-)MPROMDB
RGD ID:6824258
Promoter ID:MM_KWN:15108
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   Brain,   Kidney,   Liver,   Lung,   MEF_B6
Mouse AssemblyChrPosition (strand)Source
MGSCv3613102,462,406 - 102,462,997 (-)MPROMDB
RGD ID:6824259
Promoter ID:MM_KWN:15109
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung
Mouse AssemblyChrPosition (strand)Source
MGSCv3613102,464,066 - 102,465,007 (-)MPROMDB
RGD ID:6824257
Promoter ID:MM_KWN:15110
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000055518,   UC007RRV.1
Mouse AssemblyChrPosition (strand)Source
MGSCv3613102,537,931 - 102,538,897 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97583 AgrOrtholog
Ensembl Genes ENSMUSG00000041417 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000047004 ENTREZGENE
  ENSMUSP00000047004.7 UniProtKB/TrEMBL
  ENSMUSP00000056774.7 UniProtKB/Swiss-Prot
  ENSMUSP00000140256.2 UniProtKB/TrEMBL
  ENSMUSP00000140312.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000035532 ENTREZGENE
  ENSMUST00000035532.13 UniProtKB/TrEMBL
  ENSMUST00000055518.13 UniProtKB/Swiss-Prot
  ENSMUST00000185795.2 UniProtKB/TrEMBL
  ENSMUST00000187009.7 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.555.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ISH2_PIK3R1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_P85_iSH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_p85alpha_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3kinase_P85_cSH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3kinase_P85_nSH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18708 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K21B, ISOFORM B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PI3K_P85_iSH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pik3r1 PhenoGen
  SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P70304_MOUSE UniProtKB/TrEMBL
  P70305_MOUSE UniProtKB/TrEMBL
  P85A_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q8K3B3 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-09 Pik3r1  phosphoinositide-3-kinase regulatory subunit 1    phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)  Symbol and/or name change 5135510 APPROVED