Nppa (natriuretic peptide type A) - Rat Genome Database

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Gene: Nppa (natriuretic peptide type A) Mus musculus
Analyze
Symbol: Nppa
Name: natriuretic peptide type A
RGD ID: 11003
MGI Page MGI
Description: Predicted to enable guanylate cyclase activator activity and signaling receptor binding activity. Involved in female pregnancy and regulation of blood pressure. Acts upstream of or within cardiac muscle hypertrophy in response to stress; negative regulation of blood pressure; and sodium ion export across plasma membrane. Located in cytoplasm and extracellular space. Is expressed in several structures, including heart and skeletal muscle. Used to study hypertension. Human ortholog(s) of this gene implicated in artery disease (multiple); congestive heart failure; heart conduction disease (multiple); and peritonitis. Orthologous to human NPPA (natriuretic peptide A).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: A; Anf; ANP; atrial natriuretic factor; atrial natriuretic factor prohormone; atrial natriuretic peptide; atrial natriuretic peptide prohormone; atriopeptigen; cardiodilatin; CDD; natriuretic peptide precursor A; natriuretic peptide precursor A variant NPPA-M1; natriuretic peptide precursor A variant NPPA-M2; natriuretic peptide precursor A variant NPPA-M3; natriuretic peptide precursor type A; natriuretic peptides A; P; Pnd; preproANF; preproANP; preproCDD-ANF; prepronatriodilatin; proANF; proANP
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,085,179 - 148,086,531 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4148,085,179 - 148,086,536 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384148,000,722 - 148,002,074 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,000,722 - 148,002,079 (+)Ensemblmm10GRCm38
MGSCv374147,374,855 - 147,376,176 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364146,844,546 - 146,845,867 (+)NCBIMGSCv36mm8
Celera4150,267,117 - 150,268,440 (+)NCBICelera
Cytogenetic Map4E1NCBI
cM Map478.66NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
adenocarcinoma  (ISO)
aortic valve insufficiency  (ISO)
Atrial Dilation and Standstill  (ISO)
atrial standstill 1  (ISO)
atrial standstill 2  (ISO)
brain ischemia  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiomegaly  (IEP,ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
chromosome 1p36 deletion syndrome  (ISO)
chronic kidney disease  (ISO)
congestive heart failure  (ISO)
Contrast-Induced Nephropathy  (ISO)
coronary artery disease  (ISO)
coronary stenosis  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
diastolic heart failure  (ISO)
dilated cardiomyopathy  (ISO)
Ehlers-Danlos syndrome kyphoscoliotic type 1  (ISO)
Experimental Diabetes Mellitus  (ISO)
Familial Atrial Fibrillation 6  (ISO)
genetic disease  (ISO)
glomerulonephritis  (ISO)
heart disease  (ISO)
Hypercapnia  (ISO)
hypertension  (IAGP,ISO)
hypertrophic cardiomyopathy  (IEP,ISO)
Hypotension  (ISO)
Hypoxia  (ISO)
intrinsic cardiomyopathy  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
liver cirrhosis  (ISO)
Lung Neoplasms  (ISO)
melanoma  (ISO)
Metabolic Side Effects of Drugs and Substances  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Neoplasm Metastasis  (ISO)
nephrosis  (ISO)
obesity  (ISO)
Pain  (ISO)
patent ductus arteriosus  (ISO)
peritonitis  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (ISO)
renal hypertension  (ISO)
Right Ventricular Hypertrophy  (ISO)
Skin Neoplasms  (ISO)
small cell carcinoma  (ISO)
Stroke  (ISO)
Transplant Rejection  (ISO)
type 2 diabetes mellitus  (IEP)
ureteral obstruction  (IEP,ISO)
Urination Disorders  (ISO)
vascular dementia  (ISO)
Ventricular Remodeling  (IEP,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(R)-noradrenaline  (EXP,ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
11-deoxycorticosterone  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetyloxy-4-(trifluoromethyl)benzoic acid  (ISO)
2-Hydroxy-4-trifluoromethyl benzoic acid  (ISO)
3',5'-cyclic GMP  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-iodobenzyl-5'-N-methylcarboxamidoadenosine  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-azacytidine  (EXP)
5-fluorouracil  (EXP)
8-(3-chlorostyryl)caffeine  (ISO)
8-(4-chlorophenylthio)-cGMP  (ISO)
acetic acid  (EXP)
aconitine  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (ISO)
aldrithiol  (ISO)
all-trans-retinoic acid  (ISO)
alprenolol  (EXP)
amiodarone  (ISO)
amitrole  (ISO)
amlodipine  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
angiotensin II  (EXP,ISO)
argipressin  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
atenolol  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
atropine  (ISO)
bellidifolin  (EXP,ISO)
benazepril  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
betaxolol  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
BQ 123  (ISO)
bromochloroacetic acid  (EXP)
C60 fullerene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
candesartan  (ISO)
candoxatrilat  (ISO)
capsazepine  (ISO)
carbon monoxide  (ISO)
carvedilol  (ISO)
CGP 52608  (ISO)
CGS-21680  (ISO)
chelerythrine  (ISO)
choline  (EXP)
cilazapril monohydrate  (ISO)
clofibrate  (EXP)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
cucurbitacin I  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyanamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
D-mannitol  (ISO)
dantrolene  (ISO)
daunorubicin  (ISO)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
digoxin  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP,ISO)
doxorubicin  (EXP,ISO)
DPCPX  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
edaravone  (EXP)
ellagic acid  (ISO)
enalapril  (ISO)
ethanol  (ISO)
fasudil  (EXP)
felodipine  (ISO)
fenofibrate  (EXP)
fenvalerate  (ISO)
folic acid  (EXP)
fulvestrant  (ISO)
furosemide  (ISO)
gefitinib  (ISO)
gentamycin  (ISO)
glucose  (ISO)
glycerol  (ISO)
graphite  (EXP)
GSK2181236A  (ISO)
Guanabenz  (ISO)
GW 501516  (ISO)
haloperidol  (ISO)
HET0016  (ISO)
hydrogen peroxide  (ISO)
Ile(5)-angiotensin II  (ISO)
indinavir  (EXP)
indole-3-acetic acid  (ISO)
indometacin  (ISO)
indoxyl sulfate  (EXP,ISO)
irbesartan  (ISO)
isoprenaline  (EXP,ISO)
kenpaullone  (ISO)
KT 5720  (ISO)
L-methionine  (EXP)
labetalol  (ISO)
lamivudine  (EXP)
leptomycin B  (ISO)
linderalactone  (EXP,ISO)
lipopolysaccharide  (ISO)
lisinopril dihydrate  (ISO)
losartan  (ISO)
lovastatin  (EXP)
LY294002  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
manidipine  (ISO)
mercury dichloride  (EXP)
Mesaconitine  (ISO)
metformin  (ISO)
metoprolol  (ISO)
mevalonic acid  (ISO)
mifepristone  (EXP,ISO)
milrinone  (ISO)
monocrotaline  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
naloxone  (ISO)
nifedipine  (EXP)
nitric oxide  (ISO)
nitrofen  (ISO)
NSC 23766  (EXP)
ochratoxin A  (ISO)
omapatrilat  (ISO)
ouabain  (ISO)
paricalcitol  (ISO)
pentobarbital  (ISO)
phenformin  (ISO)
phenylephrine  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
Plantamajoside  (EXP,ISO)
prazosin  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propofol  (ISO)
propranolol  (ISO)
prostaglandin E1  (ISO)
prostaglandin E2  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
quinapril hydrochloride  (ISO)
resveratrol  (EXP,ISO)
ruthenium red  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
SB 203580  (ISO)
sildenafil citrate  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
spermine  (EXP)
spironolactone  (ISO)
staurosporine  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (EXP)
sunitinib  (ISO)
tacrolimus hydrate  (EXP)
tetrachloromethane  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP)
torasemide  (ISO)
trans-cinnamic acid  (ISO)
trans-piceid  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
U-73122  (ISO)
urethane  (ISO)
UTP  (ISO)
valproic acid  (ISO)
valsartan  (EXP,ISO)
verapamil  (ISO)
Vinpocetine  (ISO)
vorinostat  (ISO)
xestospongin C  (ISO)
Y-27632  (ISO)
zidovudine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel diameter maintenance  (IEA)
cardiac muscle hypertrophy in response to stress  (IDA,IMP)
cell growth involved in cardiac muscle cell development  (IEA,ISO)
cellular response to angiotensin  (IEA,ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hydrogen peroxide  (IEA,ISO)
cellular response to mechanical stimulus  (IEA,ISO)
cGMP biosynthetic process  (IBA,IEA,ISO,ISS)
cGMP-mediated signaling  (IBA,IEA,ISO)
female pregnancy  (IMP)
negative regulation of blood pressure  (IMP)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell growth  (IEA,ISO)
negative regulation of collecting lymphatic vessel constriction  (IEA,ISO)
negative regulation of epidermal growth factor receptor signaling pathway  (ISO)
negative regulation of JUN kinase activity  (ISO)
negative regulation of systemic arterial blood pressure  (IBA,IEA,ISO)
neuropeptide signaling pathway  (IBA,IEA,ISO)
positive regulation of cardiac muscle contraction  (IEA,ISO)
positive regulation of cGMP-mediated signaling  (IEA,ISO)
positive regulation of heart rate  (IEA,ISO)
positive regulation of potassium ion export across plasma membrane  (IEA,ISO)
protein folding  (IEA,ISO)
receptor guanylyl cyclase signaling pathway  (IBA,IEA,ISO,ISS)
regulation of atrial cardiac muscle cell membrane repolarization  (IEA,ISO)
regulation of blood pressure  (IEA,IMP,ISO)
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  (IEA,ISO)
regulation of vascular permeability  (ISO)
response to 3-methylcholanthrene  (IEA,ISO)
response to hypoxia  (IEA,ISO)
response to insulin  (IEA,ISO)
sodium ion export across plasma membrane  (IMP)
synaptic signaling via neuropeptide  (IEA,ISO)
system process  (IEA)
vasodilation  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. 3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats. Aboutabl ME, etal., Br J Pharmacol. 2009 Dec;158(7):1808-19. doi: 10.1111/j.1476-5381.2009.00461.x.
2. Ultrastructural changes, increased oxidative stress, inflammation, and altered cardiac hypertrophic gene expressions in heart tissues of rats exposed to incense smoke. Al-Attas OS, etal., Environ Sci Pollut Res Int. 2015 Jul;22(13):10083-93. doi: 10.1007/s11356-015-4212-5. Epub 2015 Feb 18.
3. Signaling mechanisms of a water soluble curcumin derivative in experimental type 1 diabetes with cardiomyopathy. Aziz MT, etal., Diabetol Metab Syndr. 2013 Mar 12;5(1):13. doi: 10.1186/1758-5996-5-13.
4. Role of atrial natriuretic peptide in the suppression of lysophosphatydic acid-induced rat aortic smooth muscle (RASM) cell growth. Baldini PM, etal., Mol Cell Biochem. 2005 Apr;272(1-2):19-28.
5. Cardioprotective role of growth/differentiation factor 1 in post-infarction left ventricular remodelling and dysfunction. Bao MW, etal., J Pathol. 2015 Jul;236(3):360-72. doi: 10.1002/path.4523. Epub 2015 Mar 30.
6. ANP but not BNP reflects early left diastolic dysfunction in type 1 diabetics with myocardial dysinnervation. Bayerle-Eder M, etal., Horm Metab Res. 2003 May;35(5):301-7.
7. Mapping genes in the mouse using single-strand conformation polymorphism analysis of recombinant inbred strains and interspecific crosses. Beier DR, etal., Proc Natl Acad Sci U S A 1992 Oct 1;89(19):9102-6.
8. Ventricular function and natriuretic peptides in sequentially combined models of hypertension. Cavallero S, etal., Am J Physiol Heart Circ Physiol. 2010 Apr;298(4):H1290-9. doi: 10.1152/ajpheart.00911.2009. Epub 2010 Feb 5.
9. Encapsulated transgene cells attenuate hypertension, cardiac hypertrophy and enhance renal function in Goldblatt hypertensive rats. Chen LG, etal., J Gene Med. 2004 Jul;6(7):786-97.
10. Increased natriuretic peptide receptor A and C gene expression in rats with pressure-overload cardiac hypertrophy. Christoffersen TE, etal., Am J Physiol Heart Circ Physiol. 2006 Apr;290(4):H1635-41. Epub 2005 Nov 4.
11. Atrial natriuretic peptide enhances recovery from ischemia/reperfusion-induced renal injury in rats. Chujo K, etal., J Biosci Bioeng. 2010 Jun;109(6):526-30. doi: 10.1016/j.jbiosc.2009.11.021. Epub 2009 Dec 23.
12. Comparison of soluble guanylate cyclase stimulators and activators in models of cardiovascular disease associated with oxidative stress. Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012.
13. Pro-A-type natriuretic peptide and pro-adrenomedullin predict progression of chronic kidney disease: the MMKD Study. Dieplinger B, etal., Kidney Int. 2009 Feb;75(4):408-14. doi: 10.1038/ki.2008.560. Epub 2008 Dec 3.
14. Association of the ScaI atrial natriuretic peptide gene polymorphism with nonfatal myocardial infarction and extent of coronary artery disease. Gruchala M, etal., Am Heart J. 2003 Jan;145(1):125-31.
15. [Effects of buyang huanwu decoction on the sarcoplasmic reticulum calcium uptake in abdominal aortic constriction induced myocardial hypertrophic rats]. Gu YP, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 May;33(5):627-31.
16. Downregulation of oxytocin and natriuretic peptides in diabetes: possible implications in cardiomyopathy. Gutkowska J, etal., J Physiol. 2009 Oct 1;587(Pt 19):4725-36. Epub 2009 Aug 12.
17. Atrial natriuretic peptide gene G664A polymorphism and the risk of ischemic cerebrovascular disease. Hassan A, etal., Neurology. 2001 Nov 13;57(9):1726-8.
18. Regional cardiac expression and concentration of natriuretic peptides in patients with severe chronic heart failure. Hystad ME, etal., Acta Physiol Scand. 2001 Apr;171(4):395-403.
19. The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling. Ji YX, etal., Nat Commun. 2016 Jun 1;7:11267. doi: 10.1038/ncomms11267.
20. Atrial natriuretic peptide attenuates the development of pulmonary hypertension in rats adapted to chronic hypoxia. Jin H, etal., J Clin Invest. 1990 Jan;85(1):115-20.
21. Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension. John SW, etal., Science. 1995 Feb 3;267(5198):679-81.
22. Effects of Atrial Natriuretic Peptide After Prolonged Hypothermic Storage of the Isolated Rat Heart. Kanamitsu H, etal., Artif Organs. 2013 Jul 4. doi: 10.1111/aor.12120.
23. Histone deacetylase inhibition improved cardiac functions with direct antifibrotic activity in heart failure. Kao YH, etal., Int J Cardiol. 2013 Aug 7. pii: S0167-5273(13)01322-3. doi: 10.1016/j.ijcard.2013.07.111.
24. Altered regulation of nitric oxide and natriuretic peptide system in cisplatin-induced nephropathy. Kim CS, etal., Regul Pept. 2012 Feb 10;174(1-3):65-70. doi: 10.1016/j.regpep.2011.12.001. Epub 2011 Dec 28.
25. Genetic disruption of atrial natriuretic peptide causes pulmonary hypertension in normoxic and hypoxic mice. Klinger JR, etal., Am J Physiol. 1999 May;276(5 Pt 1):L868-74.
26. Association of 2238T>C polymorphism of the atrial natriuretic peptide gene with coronary artery disease in Afro-Caribbeans with type 2 diabetes. Larifla L, etal., Am J Hypertens. 2012 May;25(5):524-7. doi: 10.1038/ajh.2011.233. Epub 2011 Dec 15.
27. Development of cardiac hypertrophy by sunitinib in vivo and in vitro rat cardiomyocytes is influenced by the aryl hydrocarbon receptor signaling pathway. Maayah ZH, etal., Arch Toxicol. 2014 Mar;88(3):725-38. doi: 10.1007/s00204-013-1159-5. Epub 2013 Nov 19.
28. Salt-sensitive hypertension in ANP knockout mice: potential role of abnormal plasma renin activity. Melo LG, etal., Am J Physiol. 1998 Jan;274(1 Pt 2):R255-61.
29. Salt-sensitive hypertension in ANP knockout mice is prevented by AT1 receptor antagonist losartan. Melo LG, etal., Am J Physiol. 1999 Sep;277(3 Pt 2):R624-30.
30. Chronic hypertension in ANP knockout mice: contribution of peripheral resistance. Melo LG, etal., Regul Pept. 1999 Feb 5;79(2-3):109-15.
31. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
32. MGDs mouse GO annotations MGD data from the GO Consortium
33. MGD IEA MGD IEA
34. Renal protective effects and the prevention of contrast-induced nephropathy by atrial natriuretic peptide. Morikawa S, etal., J Am Coll Cardiol. 2009 Mar 24;53(12):1040-6. doi: 10.1016/j.jacc.2008.10.061.
35. Increased human brain natriuretic peptide in congestive heart failure. Mukoyama M, etal., N Engl J Med. 1990 Sep 13;323(11):757-8.
36. NT-proANP and BNP in renovascular and in severe and mild essential hypertension. Mussalo H, etal., Kidney Blood Press Res. 2003;26(1):34-41.
37. The genetic contribution of the natriuretic peptide system to cardiovascular diseases. Nakayama T Endocr J. 2005 Feb;52(1):11-21.
38. Endothelin-1 in children with acute poststreptococcal glomerulonephritis and hypertension. Nicolaidou P, etal., Pediatr Int. 2003 Feb;45(1):35-8.
39. Natriuretic peptide/natriuretic peptide receptor-A (NPR-A) system has inhibitory effects in renal fibrosis in mice. Nishikimi T, etal., Regul Pept. 2009 Apr 10;154(1-3):44-53. doi: 10.1016/j.regpep.2009.02.006. Epub 2009 Feb 15.
40. Alterations in atrial natriuretic peptide and its receptor levels in long-term, streptozotocin-induced, diabetes in rats. Obineche E, etal., Ann N Y Acad Sci. 2006 Nov;1084:223-34.
41. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
42. Vitamin D receptor activation, left ventricular hypertrophy and myocardial fibrosis. Panizo S, etal., Nephrol Dial Transplant. 2013 Sep 7.
43. Circulating atrial natriuretic peptide genetic association study identifies a novel gene cluster associated with stroke in whites. Pereira NL, etal., Circ Cardiovasc Genet. 2015 Feb;8(1):141-9. doi: 10.1161/CIRCGENETICS.114.000624. Epub 2014 Dec 1.
44. Left ventricular SERCA2a gene down-regulation does not parallel ANP gene up-regulation during post-MI remodelling in rats. Prunier F, etal., Eur J Heart Fail. 2005 Aug;7(5):739-47.
45. Mouse MP Annotation Import Pipeline RGD automated import pipeline
46. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
47. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
48. Atrial natriuretic peptide in the vitreous humor and epiretinal membranes of patients with proliferative diabetic retinopathy. Rollin R, etal., Mol Vis. 2004 Jul 15;10:450-7.
49. Downregulation of the atrial natriuretic peptide/natriuretic peptide receptor-C system in the early stages of diabetic retinopathy in the rat. Rollin R, etal., Mol Vis. 2005 Mar 18;11:216-24.
50. Investigation of the human ANP gene in type 1 diabetic nephropathy: case-control and follow-up studies. Roussel R, etal., Diabetes. 2004 May;53(5):1394-8.
51. The gene encoding atrial natriuretic peptide and the risk of human stroke. Rubattu S, etal., Circulation. 1999 Oct 19;100(16):1722-6. doi: 10.1161/01.cir.100.16.1722.
52. Atrial natriuretic peptide gene polymorphisms and risk of ischemic stroke in humans. Rubattu S, etal., Stroke. 2004 Apr;35(4):814-8. Epub 2004 Mar 11.
53. A polymorphism in the gene for the atrial natriuretic peptide and diabetic nephropathy. Diabetic Nephropathy Study Group. Schmidt S, etal., Nephrol Dial Transplant. 1998 Jul;13(7):1807-10.
54. BMP type I receptor ALK2 is required for angiotensin II-induced cardiac hypertrophy. Shahid M, etal., Am J Physiol Heart Circ Physiol. 2016 Apr 15;310(8):H984-94. doi: 10.1152/ajpheart.00879.2015. Epub 2016 Feb 12.
55. Nuclear Translocation of Calpain-2 Mediates Apoptosis of Hypertrophied Cardiomyocytes in Transverse Aortic Constriction Rat. Sheng JJ, etal., J Cell Physiol. 2015 Nov;230(11):2743-54. doi: 10.1002/jcp.24999.
56. Elevated atrial natriuretic peptides and early renal failure in type 2 diabetic Goto-Kakizaki rats. Vesely DL, etal., Metabolism. 1999 Jun;48(6):771-8.
57. Inverse association of long-acting natriuretic peptide with metabolic syndrome in congestive heart failure patients. Wang JH, etal., Diabetol Metab Syndr. 2013 Apr 8;5(1):19. doi: 10.1186/1758-5996-5-19.
58. Function of BRD4 in the pathogenesis of high glucose‑induced cardiac hypertrophy. Wang Q, etal., Mol Med Rep. 2019 Jan;19(1):499-507. doi: 10.3892/mmr.2018.9681. Epub 2018 Nov 21.
59. Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Warden CH, etal., Genomics 1993 Nov;18(2):295-307.
60. Atrial natriuretic peptides elevate cyclic GMP levels in primary cultures of rat ependymal cells. Wellard J, etal., Neurochem Res. 2003 Feb;28(2):225-33.
61. Plasma brain natriuretic peptide levels in normotensive noninsulin-dependent diabetic patients with microalbuminuria. Yano Y, etal., J Clin Endocrinol Metab. 1999 Jul;84(7):2353-6.
62. Cosegregation analysis of natriuretic peptide genes and blood pressure in the spontaneously hypertensive rat. Ye P and West MJ, Clin Exp Pharmacol Physiol 2003 Dec;30(12):930-6.
63. Increased plasma levels and effects of brain natriuretic peptide in experimental nephrosis. Yokota N, etal., Nephron. 1993;65(3):454-9.
64. Olmesartan attenuates cardiac remodeling through DLL4/Notch1 pathway activation in pressure overload mice. You J, etal., J Cardiovasc Pharmacol. 2013 Feb;61(2):142-51. doi: 10.1097/FJC.0b013e31827a0278.
65. Growth/differentiation factor 1 alleviates pressure overload-induced cardiac hypertrophy and dysfunction. Zhang Y, etal., Biochim Biophys Acta. 2014 Feb;1842(2):232-44. doi: 10.1016/j.bbadis.2013.11.018. Epub 2013 Nov 23.
66. Meis1 promotes poly (rC)-binding protein 2 expression and inhibits angiotensin II-induced cardiomyocyte hypertrophy. Zhang Y, etal., IUBMB Life. 2016 Jan;68(1):13-22. doi: 10.1002/iub.1456. Epub 2015 Nov 24.
67. Inhibition of CYP1B1 ameliorates cardiac hypertrophy induced by uremic toxin. Zhang Y, etal., Mol Med Rep. 2020 Jan;21(1):393-404. doi: 10.3892/mmr.2019.10810. Epub 2019 Nov 11.
68. Atrial natriuretic peptide attenuates inflammatory responses on oleic acid-induced acute lung injury model in rats. Zhu YB, etal., Chin Med J (Engl). 2013 Feb;126(4):747-50.
Additional References at PubMed
PMID:1360280   PMID:1387105   PMID:1450512   PMID:1628813   PMID:1645445   PMID:1652217   PMID:1684952   PMID:1794058   PMID:1889815   PMID:1973687   PMID:2000388   PMID:2341157  
PMID:2525038   PMID:2574141   PMID:2883119   PMID:2934979   PMID:2962900   PMID:3165083   PMID:3166417   PMID:6234658   PMID:6542248   PMID:7558018   PMID:7613032   PMID:7613041  
PMID:7692743   PMID:7719023   PMID:7769089   PMID:7774930   PMID:7790005   PMID:7873878   PMID:7881131   PMID:7949731   PMID:7959737   PMID:8024008   PMID:8040308   PMID:8075499  
PMID:8083346   PMID:8097440   PMID:8104060   PMID:8182124   PMID:8188281   PMID:8196663   PMID:8199413   PMID:8227090   PMID:8288218   PMID:8288240   PMID:8380565   PMID:8415768  
PMID:8499655   PMID:8499658   PMID:8506363   PMID:8522158   PMID:8603590   PMID:8672149   PMID:8678992   PMID:8679000   PMID:8760210   PMID:8812416   PMID:8827514   PMID:8877790  
PMID:8877792   PMID:8945939   PMID:9004034   PMID:9027482   PMID:9039266   PMID:9136932   PMID:9136933   PMID:9140816   PMID:9162005   PMID:9171826   PMID:9261404   PMID:9354679  
PMID:9390273   PMID:9457670   PMID:9486664   PMID:9500550   PMID:9707587   PMID:9876177   PMID:10021345   PMID:10200993   PMID:10341097   PMID:10349636   PMID:10409505   PMID:10536674  
PMID:10537232   PMID:10613847   PMID:10710367   PMID:10733590   PMID:10807864   PMID:10848509   PMID:10882515   PMID:10888889   PMID:10892744   PMID:10912470   PMID:10920242   PMID:10926765  
PMID:10956626   PMID:11015600   PMID:11042159   PMID:11076861   PMID:11090542   PMID:11118473   PMID:11130978   PMID:11217851   PMID:11238910   PMID:11259653   PMID:11304494   PMID:11335133  
PMID:11390666   PMID:11555635   PMID:11572777   PMID:11788435   PMID:11821706   PMID:11839816   PMID:11854453   PMID:11884416   PMID:11923206   PMID:11950896   PMID:12023302   PMID:12074552  
PMID:12122109   PMID:12124219   PMID:12128222   PMID:12213803   PMID:12270041   PMID:12297045   PMID:12297046   PMID:12372253   PMID:12392994   PMID:12464436   PMID:12466851   PMID:12477932  
PMID:12563028   PMID:12692125   PMID:12702154   PMID:12738802   PMID:12756220   PMID:12781968   PMID:12859424   PMID:12867591   PMID:12970579   PMID:14499647   PMID:14573514   PMID:14610273  
PMID:14633990   PMID:14659802   PMID:14963485   PMID:14985074   PMID:15042700   PMID:15073151   PMID:15143159   PMID:15158141   PMID:15169892   PMID:15172687   PMID:15196958   PMID:15297379  
PMID:15342473   PMID:15363409   PMID:15452027   PMID:15459098   PMID:15464586   PMID:15525990   PMID:15541368   PMID:15542826   PMID:15574430   PMID:15576406   PMID:15601824   PMID:15601857  
PMID:15621532   PMID:15637153   PMID:15661756   PMID:15743826   PMID:15767668   PMID:15793309   PMID:15843407   PMID:15843409   PMID:15843414   PMID:15901664   PMID:15902305   PMID:15929941  
PMID:15939815   PMID:15958514   PMID:16132693   PMID:16141072   PMID:16141073   PMID:16199874   PMID:16314491   PMID:16314518   PMID:16335784   PMID:16374517   PMID:16380715   PMID:16530167  
PMID:16543498   PMID:16554359   PMID:16556914   PMID:16556915   PMID:16582578   PMID:16597624   PMID:16602821   PMID:16649168   PMID:16702235   PMID:16720880   PMID:16870172   PMID:17015483  
PMID:17050624   PMID:17218603   PMID:17234970   PMID:17259303   PMID:17303760   PMID:17322895   PMID:17332425   PMID:17460765   PMID:17468179   PMID:17468400   PMID:17473172   PMID:17482290  
PMID:17482496   PMID:17524563   PMID:17556662   PMID:17584735   PMID:17585069   PMID:17592028   PMID:17635645   PMID:17668378   PMID:17766470   PMID:17954558   PMID:17984325   PMID:17991884  
PMID:17996891   PMID:18192845   PMID:18246866   PMID:18267097   PMID:18276916   PMID:18285513   PMID:18292603   PMID:18316483   PMID:18332105   PMID:18448675   PMID:18467625   PMID:18470945  
PMID:18554416   PMID:18624775   PMID:18628400   PMID:18667074   PMID:18713751   PMID:18723448   PMID:18781631   PMID:18816849   PMID:19008477   PMID:19015276   PMID:19091769   PMID:19122164  
PMID:19132680   PMID:19166829   PMID:19179430   PMID:19211672   PMID:19244276   PMID:19346456   PMID:19398960   PMID:19411759   PMID:19483677   PMID:19622544   PMID:19661464   PMID:19670825  
PMID:19671135   PMID:19703439   PMID:19706423   PMID:19726871   PMID:19727199   PMID:19782130   PMID:19805191   PMID:19805384   PMID:19906950   PMID:19910509   PMID:20007915   PMID:20039448  
PMID:20080568   PMID:20080989   PMID:20139090   PMID:20167925   PMID:20194497   PMID:20352235   PMID:20403400   PMID:20439457   PMID:20457925   PMID:20540624   PMID:20562099   PMID:20596014  
PMID:20651287   PMID:20737509   PMID:20890042   PMID:20929948   PMID:20941780   PMID:20959647   PMID:21041952   PMID:21051573   PMID:21267068   PMID:21289070   PMID:21304516   PMID:21350214  
PMID:21382375   PMID:21402699   PMID:21421818   PMID:21447557   PMID:21499941   PMID:21511879   PMID:21601656   PMID:21633169   PMID:21640717   PMID:21664901   PMID:21677750   PMID:21708977  
PMID:21768366   PMID:21809340   PMID:21839733   PMID:21873635   PMID:21880664   PMID:21903139   PMID:21930795   PMID:21931855   PMID:21983003   PMID:22090424   PMID:22130515   PMID:22158707  
PMID:22158708   PMID:22192413   PMID:22267199   PMID:22288735   PMID:22343712   PMID:22403008   PMID:22412967   PMID:22437503   PMID:22577142   PMID:22589735   PMID:22829024   PMID:22898775  
PMID:22923619   PMID:22962310   PMID:22972025   PMID:22987923   PMID:23028370   PMID:23236519   PMID:23314057   PMID:23327998   PMID:23342106   PMID:23542788   PMID:23595884   PMID:23606057  
PMID:23619295   PMID:23791818   PMID:23936153   PMID:23968980   PMID:23981445   PMID:23999067   PMID:24068960   PMID:24104878   PMID:24137001   PMID:24161931   PMID:24352660   PMID:24391132  
PMID:24565998   PMID:24585447   PMID:24677751   PMID:24680892   PMID:24717731   PMID:24835278   PMID:24840128   PMID:24938781   PMID:25071214   PMID:25123163   PMID:25260157   PMID:25332179  
PMID:25336743   PMID:25445540   PMID:25487574   PMID:25497097   PMID:25521757   PMID:25670795   PMID:25703143   PMID:25917834   PMID:26098432   PMID:26487682   PMID:26493106   PMID:26517044  
PMID:26536903   PMID:26641069   PMID:26641715   PMID:26897459   PMID:27009049   PMID:27048739   PMID:27150455   PMID:27166947   PMID:27180262   PMID:27217161   PMID:27238710   PMID:27249321  
PMID:27333774   PMID:27357444   PMID:27606604   PMID:27721024   PMID:28159809   PMID:28302382   PMID:28346476   PMID:28447738   PMID:28659827   PMID:28698371   PMID:28729659   PMID:28732025  
PMID:28806941   PMID:28846746   PMID:28973536   PMID:29016838   PMID:29117561   PMID:29320742   PMID:29374072   PMID:29444209   PMID:29509905   PMID:29540665   PMID:29632206   PMID:29743679  
PMID:29802597   PMID:29853617   PMID:30016962   PMID:30151366   PMID:30580435   PMID:30700554   PMID:30765799   PMID:30898653   PMID:30920727   PMID:30936179   PMID:31034774   PMID:31077706  
PMID:31286141   PMID:31503546   PMID:31581792   PMID:31688894   PMID:31817347   PMID:32123336   PMID:32212902   PMID:32804075   PMID:32846132   PMID:32968282   PMID:33107387   PMID:33245046  
PMID:33397958   PMID:33443158   PMID:33635162   PMID:33663221   PMID:33763067   PMID:33773996   PMID:33805532   PMID:34239874   PMID:34279605   PMID:34329394   PMID:34333993   PMID:34622152  
PMID:34915728   PMID:34988124   PMID:34996942   PMID:35247074   PMID:35998113   PMID:36000401   PMID:36205127   PMID:36220812   PMID:36230906   PMID:36325906   PMID:36539111   PMID:36745292  
PMID:36877136   PMID:36899856   PMID:36927960   PMID:37067297   PMID:37572787   PMID:37852253   PMID:38014633   PMID:38196272   PMID:38226173   PMID:38235330   PMID:38382296   PMID:38794925  
PMID:38877142   PMID:39125754   PMID:39304345   PMID:39366945   PMID:40343798  


Genomics

Comparative Map Data
Nppa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,085,179 - 148,086,531 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4148,085,179 - 148,086,536 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384148,000,722 - 148,002,074 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,000,722 - 148,002,079 (+)Ensemblmm10GRCm38
MGSCv374147,374,855 - 147,376,176 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364146,844,546 - 146,845,867 (+)NCBIMGSCv36mm8
Celera4150,267,117 - 150,268,440 (+)NCBICelera
Cytogenetic Map4E1NCBI
cM Map478.66NCBI
NPPA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,845,709 - 11,847,783 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,845,709 - 11,848,345 (-)Ensemblhg38GRCh38
GRCh37111,905,766 - 11,907,840 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,828,363 - 11,830,422 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34111,840,041 - 11,842,101NCBI
Celera111,019,389 - 11,021,472 (-)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef111,060,823 - 11,062,905 (-)NCBIHuRef
CHM1_1111,893,660 - 11,895,736 (-)NCBICHM1_1
T2T-CHM13v2.0111,389,795 - 11,391,868 (-)NCBIT2T-CHM13v2.0
Nppa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85163,712,184 - 163,713,493 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5163,712,184 - 163,713,493 (+)EnsemblGRCr8
mRatBN7.25158,429,042 - 158,430,351 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5158,429,042 - 158,430,351 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5161,145,793 - 161,147,102 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05162,973,730 - 162,975,039 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05162,930,077 - 162,931,386 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05164,808,407 - 164,809,716 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5164,808,323 - 164,809,705 (+)Ensemblrn6Rnor6.0
Rnor_5.05168,466,309 - 168,467,618 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45165,074,518 - 165,075,827 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5156,710,885 - 156,712,194 (+)NCBICelera
RGSC_v3.15165,084,713 - 165,086,000 (+)NCBI
RH 3.4 Map51106.6RGD
Cytogenetic Map5q36NCBI
Nppa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554862,060,735 - 2,063,003 (+)Ensembl
ChiLan1.0NW_0049554862,061,196 - 2,062,805 (+)NCBIChiLan1.0ChiLan1.0
NPPA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21216,375,951 - 216,382,131 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11215,021,064 - 215,023,807 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0110,608,025 - 10,610,287 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,825,072 - 11,827,452 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,825,072 - 11,827,373 (-)EnsemblpanPan2panpan1.1
NPPA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,406,317 - 84,408,115 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,396,073 - 84,408,385 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha280,939,561 - 80,941,359 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0285,071,241 - 85,073,039 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl285,060,271 - 85,073,309 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,819,847 - 81,821,645 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0282,819,771 - 82,821,568 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0283,882,545 - 83,884,343 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nppa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505834,846,575 - 34,848,291 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936474671,362 - 673,610 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPPA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl671,918,845 - 71,921,405 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1671,919,557 - 71,921,345 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,829,057 - 65,830,990 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPPA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120119,942,412 - 119,946,211 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20119,944,532 - 119,945,917 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605423,811,217 - 23,814,235 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nppa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248181,147,974 - 1,148,927 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248181,147,654 - 1,149,722 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Nppa
62 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:120
Count of miRNA genes:104
Interacting mature miRNAs:114
Transcripts:ENSMUST00000103230
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301267Bcmd2_mB cell maturation defect 2 (mouse)Not determined4133154678150789451Mouse
4142077Ignpq2_mIgA nephropathy QTL 2 (mouse)Not determined4133676733156860686Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120674005154674151Mouse
1301584Lrdg2_mlight induced retinal degeneration 2 (mouse)Not determined4129465811151654550Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4119864433153864536Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4127784226156860686Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124264957150676858Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121342649155342753Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124621281156860686Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120674005154674151Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121342649155342753Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125230872156860686Mouse
1300874Gasa2_mgastritis type A susceptibility locus 2 (mouse)Not determined4133010494156860686Mouse
1300553Athsq1_matherosclerosis susceptibility QTL 1 (mouse)Not determined4137617848151654550Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125230872156860686Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4119864433153864536Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121342649155342753Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116154678150154782Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
1301108Scon2_msucrose consumption 2 (mouse)Not determined4134654451156860686Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124621281156860686Mouse
1300537Ap3q_malcohol preference 3 QTL (mouse)Not determined4134654451156860686Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120617848154617995Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117401141151401275Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125230872156860686Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4127784226156860686Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124553483156860686Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125289325156860686Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120617848154617995Mouse
12738431Lfibq20_mliver fibrosis QTL 20 (mouse)4144699835148907426Mouse
4141184Tb2r1_mTGF-beta2 responsiveness 1 (mouse)Not determined137674005150676858Mouse
1300780Cocrb16_mcocaine related behavior 16 (mouse)Not determined4138943725156860686Mouse

Markers in Region
PMC123178P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384148,000,831 - 148,001,342UniSTSGRCm38
MGSCv374147,374,940 - 147,375,451UniSTSGRCm37
Celera4150,267,204 - 150,267,715UniSTS
Cytogenetic Map4E2UniSTS
cM Map476.5UniSTS
PMC26660P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384148,001,203 - 148,001,994UniSTSGRCm38
MGSCv374147,375,312 - 147,376,103UniSTSGRCm37
Celera4150,267,576 - 150,268,367UniSTS
Cytogenetic Map4E2UniSTS
cM Map476.5UniSTS
PMC316718P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384148,000,889 - 148,001,381UniSTSGRCm38
MGSCv374147,374,998 - 147,375,490UniSTSGRCm37
Celera4150,267,262 - 150,267,754UniSTS
Cytogenetic Map4E2UniSTS
cM Map476.5UniSTS
Nppa  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384148,001,148 - 148,001,387UniSTSGRCm38
MGSCv374147,375,257 - 147,375,496UniSTSGRCm37
Celera4150,267,521 - 150,267,760UniSTS
Cytogenetic Map4E2UniSTS
cM Map476.5UniSTS
cM Map476.5UniSTS
Nppa  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384148,002,044 - 148,002,217UniSTSGRCm38
MGSCv374147,376,153 - 147,376,326UniSTSGRCm37
Celera4150,268,417 - 150,268,590UniSTS
Cytogenetic Map4E2UniSTS
cM Map476.5UniSTS
Nppa  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384148,001,362 - 148,001,797UniSTSGRCm38
MGSCv374147,375,471 - 147,375,906UniSTSGRCm37
Celera4150,267,735 - 150,268,170UniSTS
Cytogenetic Map4E2UniSTS
cM Map476.5UniSTS
Nppa  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384148,000,923 - 148,001,211UniSTSGRCm38
MGSCv374147,375,032 - 147,375,320UniSTSGRCm37
Celera4150,267,296 - 150,267,584UniSTS
Cytogenetic Map4E2UniSTS
cM Map476.5UniSTS
Nppa  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384148,001,343 - 148,001,934UniSTSGRCm38
MGSCv374147,375,452 - 147,376,043UniSTSGRCm37
Celera4150,267,716 - 150,268,307UniSTS
Cytogenetic Map4E2UniSTS
Nppa  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4E2UniSTS
Nppa  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384148,000,470 - 148,000,847UniSTSGRCm38
MGSCv374147,374,579 - 147,374,956UniSTSGRCm37
Celera4150,266,841 - 150,267,220UniSTS
Cytogenetic Map4E2UniSTS
cM Map476.5UniSTS
Nppa  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4E2UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000103230   ⟹   ENSMUSP00000099520
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,085,179 - 148,086,536 (+)Ensembl
GRCm38.p6 Ensembl4148,000,722 - 148,002,079 (+)Ensembl
RefSeq Acc Id: NM_008725   ⟹   NP_032751
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394148,085,179 - 148,086,531 (+)NCBI
GRCm384148,000,722 - 148,002,074 (+)NCBI
MGSCv374147,374,855 - 147,376,176 (+)RGD
Celera4150,267,117 - 150,268,440 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032751   ⟸   NM_008725
- Peptide Label: preproprotein
- UniProtKB: Q5FW59 (UniProtKB/Swiss-Prot),   P05125 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000099520   ⟸   ENSMUST00000103230

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P05125-F1-model_v2 AlphaFold P05125 1-152 view protein structure

Promoters
RGD ID:6835761
Promoter ID:MM_KWN:40792
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain
Transcripts:OTTMUST00000023685
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364147,374,451 - 147,375,237 (+)MPROMDB
RGD ID:6850074
Promoter ID:EP11133
Type:single initiation site
Name:MM_ANF
Description:Pronatriodilatin, Atrial natriuretic factor, NPPA or PND gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 83; Mammalian pronatriodilatin
Tissues & Cell Lines:cardiac atrium
Experiment Methods:Nuclease protection; experiments performed with closely related; gene; Sequencing of a full-length cDNA; experiments performed with; closely related gene
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv374147,374,850 - 147,374,910EPD
MGSCv364147,374,850 - 147,374,910EPD
RGD ID:6885488
Promoter ID:EPDNEW_M6195
Type:multiple initiation site
Name:ANF_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384148,000,741 - 148,000,801EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97367 AgrOrtholog
Ensembl Genes ENSMUSG00000041616 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000103230 ENTREZGENE
  ENSMUST00000103230.5 UniProtKB/Swiss-Prot
InterPro Natr_peptide UniProtKB/Swiss-Prot
  Natr_peptide_CS UniProtKB/Swiss-Prot
  Natriuretic_peptide UniProtKB/Swiss-Prot
  Natriuretic_peptide_atrial UniProtKB/Swiss-Prot
KEGG Report mmu:230899 UniProtKB/Swiss-Prot
MGD MGI:97367 ENTREZGENE
NCBI Gene Nppa ENTREZGENE
PANTHER ATRIAL NATRIURETIC FACTOR PRECURSOR UniProtKB/Swiss-Prot
  NATRIURETIC PEPTIDES A UniProtKB/Swiss-Prot
Pfam ANP UniProtKB/Swiss-Prot
PhenoGen Nppa PhenoGen
PRINTS ANATPEPTIDE UniProtKB/Swiss-Prot
  NATPEPTIDES UniProtKB/Swiss-Prot
PROSITE NATRIURETIC_PEPTIDE UniProtKB/Swiss-Prot
SMART NAT_PEP UniProtKB/Swiss-Prot
UniProt ANF_MOUSE UniProtKB/Swiss-Prot
  N0A5N9_MOUSE UniProtKB/TrEMBL
  P05125 ENTREZGENE
  Q5FW59 ENTREZGENE
UniProt Secondary Q5FW59 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-09-25 Nppa  natriuretic peptide type A  Nppa  natriuretic peptide precursor type A  Symbol and/or name change 5135510 APPROVED
2024-08-21 Nppa  natriuretic peptide precursor type A  Nppa  natriuretic peptide type A  Symbol and/or name change 5135510 APPROVED
2011-07-27 Nppa  natriuretic peptide type A  Nppa  natriuretic peptide precursor type A  Symbol and/or name change 5135510 APPROVED