Notch1 (notch 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Notch1 (notch 1) Mus musculus
Analyze
Symbol: Notch1
Name: notch 1
RGD ID: 10998
MGI Page MGI
Description: Enables several functions, including Notch binding activity; transcription coactivator activity; and transcription regulator activator activity. Involved in several processes, including circulatory system development; negative regulation of cell differentiation; and regulation of signal transduction. Acts upstream of or within several processes, including circulatory system development; epithelial cell differentiation; and regulation of epithelial cell differentiation. Located in several cellular components, including adherens junction; apical plasma membrane; and cell surface. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia/lymphoma; aortic valve disease 1; and congenital heart disease. Orthologous to human NOTCH1 (notch receptor 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9930111A19Rik; lin; lin-12; major type A protein; Mi; Mis6; Motch A; mT14; N; N1; neurogenic locus notch homolog protein 1; Notch gene homolog 1; p300; Ta; Tan1; transmembrane receptor Notch1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39226,347,914 - 26,393,834 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl226,347,915 - 26,406,675 (-)EnsemblGRCm39 Ensembl
GRCm38226,457,902 - 26,503,822 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl226,457,903 - 26,516,663 (-)EnsemblGRCm38mm10GRCm38
MGSCv37226,313,422 - 26,359,342 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36226,280,033 - 26,325,646 (-)NCBIMGSCv36mm8
Celera226,175,736 - 26,221,759 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map218.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Adams-Oliver syndrome  (ISO)
Adams-Oliver Syndrome 2  (ISO)
Adams-Oliver Syndrome 5  (ISO)
adenoid cystic carcinoma  (ISO)
adenoiditis  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
amyotrophic lateral sclerosis  (IEP)
aortic valve disease  (ISO)
aortic valve disease 1  (ISO)
ARTERIAL DISSECTION  (ISO)
atherosclerosis  (IEP)
autism spectrum disorder  (ISO)
autosomal dominant intellectual developmental disorder 8  (ISO)
autosomal dominant nocturnal frontal lobe epilepsy 5  (ISO)
autosomal recessive limb-girdle muscular dystrophy type 2A  (ISO)
bicuspid aortic valve disease  (ISO)
Breast Neoplasms  (ISO)
Calcification of Aortic Valve  (ISO)
calcinosis  (ISO)
Cardiomegaly  (IEP)
Cardiovascular Abnormalities  (ISO)
Carotid Artery Injuries  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholangiocarcinoma  (ISO)
cholesteatoma of middle ear  (ISO)
Colonic Neoplasms  (ISO)
Congenital Abnormalities  (ISO)
congenital heart disease  (ISO)
connective tissue disease  (ISO)
Craniofacial Abnormalities  (ISO)
developmental and epileptic encephalopathy 14  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Foot  (ISO)
diabetic retinopathy  (IMP)
Ehlers-Danlos syndrome classic type 1  (ISO)
Ehlers-Danlos syndrome hypermobility type  (ISO)
endometrial cancer  (ISO)
epilepsy  (ISO)
esophageal atresia  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Liver Neoplasms  (ISO)
Focal Nodular Hyperplasia  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
heart valve disease  (ISO)
hemangiopericytoma  (ISO)
Hypertrophic Cicatrix  (ISO)
hypoplastic left heart syndrome  (ISO)
Joubert syndrome 1  (ISO)
keratoacanthoma  (ISO)
Kleefstra syndrome 1  (ISO)
Leigh disease  (ISO)
lung adenocarcinoma  (ISO)
lung large cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lymphoma  (ISO)
malignant astrocytoma  (ISO)
Marfan syndrome  (ISO)
Marfanoid Hypermobility Syndrome  (ISO)
microphthalmia  (ISO)
myeloproliferative neoplasm  (ISO)
Myocardial Ischemia  (ISO)
Neoplastic Cell Transformation  (ISO)
nervous system disease  (ISO)
oral squamous cell carcinoma  (IEP)
pancreatic cancer  (IMP)
pancreatic ductal carcinoma  (IMP,ISO)
Peritoneal Diseases  (ISO)
primary coenzyme Q10 deficiency 7  (ISO)
prion disease  (IEP)
Pulmonary Arterial Hypertension  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (IDA)
Rafiq syndrome  (ISO)
retinopathy of prematurity  (ISO)
scoliosis  (ISO)
SHONE COMPLEX  (ISO)
Skin Neoplasms  (ISO)
Splenomegaly  (ISO)
squamous cell carcinoma  (ISO)
Surgical Wound  (IMP)
syndromic microphthalmia 5  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
tetralogy of Fallot  (ISO)
thoracic aortic aneurysm  (ISO)
transient cerebral ischemia  (ISO)
tuberous sclerosis 1  (ISO)
Uterine Cervical Neoplasms  (ISO)
Vascular Malformations  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-dexrazoxane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-acetamidofluorene  (EXP)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylfuran  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
aconitine  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (EXP)
ammonium chloride  (ISO)
arecoline  (EXP)
aristolochic acid A  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (EXP,ISO)
azoxystrobin  (ISO)
baicalein  (ISO)
baicalin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
beta-naphthoflavone  (EXP)
BI-2536  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Botulinum toxin type A  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calciol  (EXP,ISO)
captan  (EXP)
carbon nanotube  (EXP)
chloroquine  (ISO)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (EXP)
chrysene  (EXP)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
clobetasol  (EXP)
cobalt dichloride  (ISO)
cordycepin  (ISO)
Crenigacestat  (ISO)
crocidolite asbestos  (EXP)
Cuprizon  (ISO)
curcumin  (ISO)
Cyclopamine  (ISO)
cyclophosphamide  (ISO)
DAPT  (EXP,ISO)
DDT  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
doxorubicin  (EXP,ISO)
emodin  (EXP,ISO)
enzalutamide  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
eugenol  (EXP,ISO)
Evodiamine  (ISO)
fenamidone  (EXP)
fenofibrate  (EXP)
fluoxetine  (ISO)
folic acid  (ISO)
folpet  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (ISO)
galactose  (EXP)
gemcitabine  (ISO)
gentamycin  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
hexadecanoic acid  (ISO)
HT-2 toxin  (ISO)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
isoflavones  (ISO)
isoprenaline  (ISO)
kaempferol 3-O-beta-D-glucoside  (EXP)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
LY294002  (EXP,ISO)
mebendazole  (ISO)
methoxyacetic acid  (EXP)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP,ISO)
miconazole  (EXP)
Mitotane  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monocrotaline  (ISO)
monosodium L-glutamate  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nickel dichloride  (ISO)
niclosamide  (ISO)
nicotinic acid  (ISO)
nocodazole  (ISO)
Nutlin-3  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
omacetaxine mepesuccinate  (ISO)
oxaliplatin  (ISO)
oxidopamine  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
Paeonol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentachlorophenol  (EXP)
phenethyl isothiocyanate  (ISO)
picropodophyllotoxin  (ISO)
pifithrin-alpha hydrobromide  (ISO)
pirinixic acid  (EXP)
pluronic P-123  (ISO)
Poloxamer  (ISO)
poly(ethylene)  (ISO)
potassium chromate  (ISO)
progesterone  (EXP)
propiconazole  (EXP)
propranolol  (ISO)
prostaglandin F2alpha  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
retinyl acetate  (EXP)
rotenone  (ISO)
Salidroside  (EXP)
SB 203580  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
tetraphene  (EXP)
thioacetamide  (ISO)
thiram  (ISO)
thymoquinone  (ISO)
Tiron  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
trans-caffeic acid  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (EXP)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
tungsten  (EXP)
tunicamycin  (EXP)
tyrphostin AG 1478  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
wortmannin  (EXP)
zalcitabine  (EXP)
zearalenone  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA)
animal organ regeneration  (IEA,ISO)
aortic valve morphogenesis  (IEA,IGI,IMP,ISO,ISS)
apoptotic process  (IDA)
apoptotic process involved in embryonic digit morphogenesis  (IMP)
arterial endothelial cell differentiation  (IMP)
artery morphogenesis  (IEA)
astrocyte differentiation  (IEA,ISO)
atrioventricular node development  (IMP)
atrioventricular valve morphogenesis  (IMP)
auditory receptor cell fate commitment  (IMP)
axon guidance  (IBA)
axonogenesis  (IDA,IMP)
branching morphogenesis of an epithelial tube  (IMP)
calcium-ion regulated exocytosis  (IMP)
camera-type eye morphogenesis  (IEA)
cardiac atrium morphogenesis  (IMP)
cardiac chamber formation  (IMP)
cardiac epithelial to mesenchymal transition  (IMP)
cardiac left ventricle morphogenesis  (IMP)
cardiac muscle cell myoblast differentiation  (IMP)
cardiac muscle cell proliferation  (IMP)
cardiac muscle tissue morphogenesis  (IMP)
cardiac right atrium morphogenesis  (IMP)
cardiac right ventricle formation  (IMP)
cardiac septum morphogenesis  (IMP)
cardiac vascular smooth muscle cell development  (IMP)
cardiac ventricle morphogenesis  (IMP)
cell differentiation  (IEA,IMP)
cell differentiation in spinal cord  (IEA,ISO)
cell fate commitment  (IEA)
cell migration involved in endocardial cushion formation  (IMP)
cell population proliferation  (IGI)
cellular response to follicle-stimulating hormone stimulus  (IEA,ISO)
cellular response to hypoxia  (IDA)
cellular response to tumor cell  (IEA,ISO)
cellular response to vascular endothelial growth factor stimulus  (IEA,ISO,ISS)
central nervous system neuron differentiation  (IMP)
chemical synaptic transmission, postsynaptic  (IDA,IMP)
cilium assembly  (ISS)
collecting duct development  (IEP)
compartment pattern specification  (IMP)
coronary artery morphogenesis  (IMP)
coronary sinus valve morphogenesis  (IMP)
coronary vein morphogenesis  (IMP)
determination of left/right symmetry  (IMP)
developmental growth  (IEA)
distal tubule development  (IEP)
embryonic hindlimb morphogenesis  (IMP)
embryonic limb morphogenesis  (IEA,IGI)
endocardial cell differentiation  (IMP)
endocardial cushion development  (IMP)
endocardial cushion morphogenesis  (IGI,IMP)
endocardium development  (IMP)
endocardium morphogenesis  (IEP,IMP)
endoderm development  (IMP)
epidermal cell fate specification  (IMP)
epidermis development  (IGI)
epithelial cell development  (IEA)
epithelial cell differentiation involved in kidney development  (IEA)
epithelial cell fate commitment  (IMP)
epithelial cell proliferation  (IGI,IMP)
epithelial to mesenchymal transition  (IEA,IMP,ISO)
epithelial to mesenchymal transition involved in endocardial cushion formation  (IMP)
forebrain development  (IGI,IMP)
foregut morphogenesis  (IMP)
gene expression  (IDA)
glial cell differentiation  (IMP)
glomerular mesangial cell development  (IEP)
glomerulus vasculature development  (IEA)
growth involved in heart morphogenesis  (IMP)
hair follicle morphogenesis  (IMP)
heart development  (IEA,ISO)
heart looping  (IEA,IGI)
heart trabecula morphogenesis  (IMP)
homeostasis of number of cells within a tissue  (IGI)
humoral immune response  (IEA,IGI)
in utero embryonic development  (IEA,IMP)
inflammatory response to antigenic stimulus  (IEA,IGI)
inhibition of neuroepithelial cell differentiation  (IMP)
interleukin-17-mediated signaling pathway  (IDA)
keratinocyte differentiation  (IGI,IMP)
left/right axis specification  (IEA,IGI)
liver development  (IMP)
lung development  (IMP)
luteolysis  (IEA,ISO)
mesenchymal cell development  (IMP)
mitral valve formation  (IEA,ISO)
morphogenesis of an epithelial sheet  (IEA)
negative regulation of anoikis  (IEA,ISO)
negative regulation of biomineral tissue development  (IDA,IMP)
negative regulation of BMP signaling pathway  (IMP)
negative regulation of calcium ion-dependent exocytosis  (IMP)
negative regulation of canonical Wnt signaling pathway  (IMP)
negative regulation of cardiac muscle cell apoptotic process  (IEA,ISO)
negative regulation of cardiac muscle hypertrophy  (IMP)
negative regulation of catalytic activity  (IDA)
negative regulation of cell adhesion molecule production  (IEA,ISO)
negative regulation of cell migration involved in sprouting angiogenesis  (IEA,ISO,ISS)
negative regulation of cell population proliferation  (IEA,ISO,ISS)
negative regulation of cell proliferation involved in heart valve morphogenesis  (IDA,IMP)
negative regulation of cell-cell adhesion mediated by cadherin  (IEA,ISO)
negative regulation of cell-substrate adhesion  (IEA,ISO)
negative regulation of cold-induced thermogenesis  (IMP)
negative regulation of collagen biosynthetic process  (IEA,ISO)
negative regulation of DNA-templated transcription  (IDA,IMP)
negative regulation of endothelial cell chemotaxis  (IEA,ISO,ISS)
negative regulation of epithelial cell proliferation  (IMP)
negative regulation of extracellular matrix constituent secretion  (IMP)
negative regulation of gene expression  (IEA,ISO)
negative regulation of glial cell proliferation  (IDA)
negative regulation of inner ear auditory receptor cell differentiation  (IMP)
negative regulation of myoblast differentiation  (IEA,ISO)
negative regulation of myotube differentiation  (IMP)
negative regulation of neurogenesis  (IMP)
negative regulation of neuron differentiation  (IEA,IGI,IMP,ISO)
negative regulation of oligodendrocyte differentiation  (IDA)
negative regulation of ossification  (IMP)
negative regulation of osteoblast differentiation  (IMP)
negative regulation of photoreceptor cell differentiation  (IMP)
negative regulation of pro-B cell differentiation  (IMP)
negative regulation of programmed cell death  (IMP)
negative regulation of stem cell differentiation  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IDA,IEA,IMP,ISO)
nephron tubule development  (IEA)
neural tube development  (IMP)
neuroendocrine cell differentiation  (IMP)
neuron differentiation  (IGI,IMP)
neuron fate commitment  (IGI)
neuronal stem cell population maintenance  (IEA)
Notch signaling pathway  (IBA,IC,IDA,IEA,IGI,IMP,ISO,ISS)
Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation  (IMP)
oligodendrocyte differentiation  (IEA,IMP,ISO)
osteoblast fate commitment  (NAS)
outflow tract morphogenesis  (IEA,ISO)
pericardium morphogenesis  (IMP)
positive regulation of aorta morphogenesis  (IMP)
positive regulation of apoptotic process  (IDA,IGI)
positive regulation of apoptotic process involved in morphogenesis  (IDA)
positive regulation of astrocyte differentiation  (IDA)
positive regulation of BMP signaling pathway  (IDA,IEA)
positive regulation of cardiac epithelial to mesenchymal transition  (IEA,ISO)
positive regulation of cardiac muscle cell proliferation  (IMP)
positive regulation of cell development  (IEA)
positive regulation of cell migration  (IMP)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of DNA-templated transcription  (IDA)
positive regulation of endothelial cell differentiation  (IEA,ISO)
positive regulation of ephrin receptor signaling pathway  (IC)
positive regulation of epithelial cell differentiation  (IEA)
positive regulation of epithelial cell proliferation  (IGI)
positive regulation of epithelial to mesenchymal transition  (IEA,IMP)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of gene expression  (IEA,IGI,ISO)
positive regulation of glial cell differentiation  (IEA,ISO)
positive regulation of keratinocyte differentiation  (IDA,IGI)
positive regulation of neuroblast proliferation  (IEA,ISO)
positive regulation of Notch signaling pathway  (IDA)
positive regulation of Ras protein signal transduction  (IEA,ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (IDA)
positive regulation of smooth muscle cell differentiation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IEA,IGI,IMP,ISO)
positive regulation of transcription of Notch receptor target  (IEA,IGI,ISO)
positive regulation of viral genome replication  (IMP)
positive regulation of viral transcription  (IMP)
prostate gland epithelium morphogenesis  (IMP)
protein catabolic process  (IDA)
protein import into nucleus  (IDA)
pulmonary valve morphogenesis  (IEA,IGI,IMP,ISO)
regulation of apoptotic process  (IEA)
regulation of cardioblast proliferation  (IEA,ISO)
regulation of cell adhesion involved in heart morphogenesis  (IMP)
regulation of cell migration  (IMP)
regulation of cell population proliferation  (IEA,ISO)
regulation of developmental process  (IEA)
regulation of DNA-templated transcription  (IEA)
regulation of epithelial cell proliferation  (IGI,IMP)
regulation of epithelial cell proliferation involved in prostate gland development  (IMP)
regulation of extracellular matrix assembly  (IMP)
regulation of gene expression  (IMP)
regulation of inner ear auditory receptor cell differentiation  (IMP)
regulation of neurogenesis  (IMP)
regulation of Notch signaling pathway  (IGI)
regulation of postsynaptic neurotransmitter receptor activity  (IDA,IMP)
regulation of secondary heart field cardioblast proliferation  (IMP)
regulation of somitogenesis  (IMP)
regulation of stem cell proliferation  (IMP)
regulation of transcription by RNA polymerase II  (IGI,IMP)
reproductive structure development  (IEA)
response to lipopolysaccharide  (IEA,ISO)
response to muramyl dipeptide  (IDA)
retinal cone cell differentiation  (IMP)
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development  (IMP)
skeletal muscle cell differentiation  (IMP)
somatic stem cell division  (IDA,IGI)
spermatogenesis  (IEA,ISO)
sprouting angiogenesis  (IMP)
T-helper 17 type immune response  (IDA)
tissue regeneration  (IEA,ISO)
transcription by RNA polymerase II  (IDA,IGI)
tube formation  (IEA,ISO,ISS)
vasculogenesis involved in coronary vascular morphogenesis  (IMP)
venous blood vessel morphogenesis  (IMP)
venous endothelial cell differentiation  (IMP)
ventricular septum morphogenesis  (IEA,IGI,IMP,ISO)
ventricular trabecula myocardium morphogenesis  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal angiogenesis  (IAGP)
abnormal anterior cardinal vein morphology  (IAGP)
abnormal aortic valve morphology  (IAGP)
abnormal apoptosis  (IAGP)
abnormal artery morphology  (IAGP)
abnormal atrioventricular cushion morphology  (IAGP)
abnormal B cell differentiation  (IAGP)
abnormal B cell morphology  (IAGP)
abnormal branching involved in pancreas development  (IAGP)
abnormal cardiac epithelial to mesenchymal transition  (IAGP)
abnormal cell death  (IAGP)
abnormal cochlear inner hair cell morphology  (IAGP)
abnormal cornea morphology  (IAGP)
abnormal coronary vessel morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal dendritic cell differentiation  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal direction of heart looping  (IAGP)
abnormal dorsal aorta morphology  (IAGP)
abnormal embryo development  (IAGP)
abnormal embryonic neuroepithelium morphology  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal endocrine pancreas morphology  (IAGP)
abnormal hair follicle melanocyte morphology  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal hair growth  (IAGP)
abnormal hair shaft morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal hepatic cord morphology  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal intersomitic vessel morphology  (IAGP)
abnormal left-right axis patterning  (IAGP)
abnormal left-right axis symmetry of the somites  (IAGP)
abnormal liver lobule morphology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal liver parenchyma morphology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal nervous system development  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal pancreas development  (IAGP)
abnormal pancreatic acinus morphology  (IAGP)
abnormal pancreatic bud formation  (IAGP)
abnormal pericyte morphology  (IAGP)
abnormal placenta vasculature  (IAGP)
abnormal placental labyrinth vasculature morphology  (IAGP)
abnormal postnatal subventricular zone morphology  (IAGP)
abnormal response to infection  (IAGP)
abnormal retina blood vessel morphology  (IAGP)
abnormal retina vasculature morphology  (IAGP)
abnormal rostral migratory stream morphology  (IAGP)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal somite development  (IAGP)
abnormal somite size  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell receptor beta chain V(D)J recombination  (IAGP)
abnormal thymus cell ratio  (IAGP)
abnormal thymus morphology  (IAGP)
abnormal trigeminal ganglion morphology  (IAGP)
abnormal vascular branching morphogenesis  (IAGP)
abnormal vascular development  (IAGP)
abnormal vascular plexus formation  (IAGP)
abnormal vascular smooth muscle morphology  (IAGP)
abnormal vasculogenesis  (IAGP)
abnormal vein morphology  (IAGP)
abnormal venule morphology  (IAGP)
abnormal vertebrae morphology  (IAGP)
abnormal vitelline vascular remodeling  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent coronary vessels  (IAGP)
absent hair follicle inner root sheath  (IAGP)
absent sebaceous gland  (IAGP)
absent vitelline blood vessels  (IAGP)
alopecia  (IAGP)
anemia  (IAGP)
aortic valve inflammation  (IAGP)
arrested T cell differentiation  (IAGP)
arteriovenous malformation  (IAGP)
bicuspid aortic valve  (IAGP)
calcified aortic valve cusp  (IAGP)
chronic liver inflammation  (IAGP)
cornea deposits  (IAGP)
cornea vascularization  (IAGP)
decreased angiogenesis  (IAGP)
decreased body weight  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased conjunctiva goblet cell number  (IAGP)
decreased double-negative T cell number  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased embryo size  (IAGP)
decreased interleukin-4 secretion  (IAGP)
decreased organ of Corti supporting cell number  (IAGP)
decreased pancreatic islet number  (IAGP)
decreased single-positive T cell number  (IAGP)
decreased T cell number  (IAGP)
decreased thymocyte number  (IAGP)
delayed heart looping  (IAGP)
delayed somite formation  (IAGP)
dilated liver sinusoidal space  (IAGP)
diluted coat color  (IAGP)
disorganized inner root sheath cells  (IAGP)
disorganized myocardium  (IAGP)
distended pericardium  (IAGP)
dry eyes  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality  (IAGP)
embryonic lethality during organogenesis  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged spleen  (IAGP)
epidermal hyperplasia  (IAGP)
extramedullary hematopoiesis  (IAGP)
hair follicle degeneration  (IAGP)
hemopericardium  (IAGP)
hemoperitoneum  (IAGP)
hemorrhage  (IAGP)
impaired basement membrane formation  (IAGP)
incomplete embryo turning  (IAGP)
incomplete somite formation  (IAGP)
increased angiogenesis  (IAGP)
increased apoptosis  (IAGP)
increased cochlear inner hair cell number  (IAGP)
increased cochlear outer hair cell number  (IAGP)
increased grip strength  (IEA)
increased hemangioma incidence  (IAGP)
increased hematopoietic cell number  (IAGP)
increased immature B cell number  (IAGP)
increased leukemia incidence  (IAGP)
increased neuron number  (IAGP)
increased single-positive T cell number  (IAGP)
increased spleen red pulp amount  (IAGP)
increased startle reflex  (IEA)
increased T cell apoptosis  (IAGP)
increased vascular permeability  (IAGP)
internal hemorrhage  (IAGP)
kinked neural tube  (IAGP)
lacrimal gland degeneration  (IAGP)
Meibomian gland degeneration  (IAGP)
myocardium hypoplasia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neural tube degeneration  (IAGP)
no abnormal phenotype detected  (IAGP)
notochord degeneration  (IAGP)
open neural tube  (IAGP)
pale liver  (IAGP)
pale yolk sac  (IAGP)
pericardial edema  (IAGP)
pericardial effusion  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IEA)
progressive hair loss  (IAGP)
renal hypoplasia  (IAGP)
scaly skin  (IAGP)
short hair  (IAGP)
small pancreas  (IAGP)
small pharyngeal arch  (IAGP)
small sebaceous gland  (IAGP)
small thymus  (IAGP)
thick aortic valve cusps  (IAGP)
thick epidermis  (IAGP)
thin myocardium  (IAGP)
thin myocardium compact layer  (IAGP)
thymus hypoplasia  (IAGP)
trabecula carnea hypoplasia  (IAGP)
waved hair  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Functional genomics and gene-environment interaction highlight the complexity of congenital heart disease caused by Notch pathway variants. Chapman G, etal., Hum Mol Genet. 2020 Mar 13;29(4):566-579. doi: 10.1093/hmg/ddz270.
2. Ranolazine protects against diabetic cardiomyopathy by activating the NOTCH1/NRG1 pathway. Chen X, etal., Life Sci. 2020 Nov 15;261:118306. doi: 10.1016/j.lfs.2020.118306. Epub 2020 Aug 21.
3. Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia. De La O JP, etal., Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18907-12. Epub 2008 Nov 21.
4. Thalidomide-induced angiopoietin 2, Notch1 and Dll4 downregulation under hypoxic condition in tissues with gastrointestinal vascular malformation and human umbilical vein endothelial cells. Feng Q, etal., J Dig Dis. 2014 Feb;15(2):85-95. doi: 10.1111/1751-2980.12114.
5. Cell and molecular biology of Notch. Fiuza UM and Arias AM, J Endocrinol. 2007 Sep;194(3):459-74.
6. Mutations in NOTCH1 cause aortic valve disease. Garg V, etal., Nature. 2005 Sep 8;437(7056):270-4. Epub 2005 Jul 17.
7. Notch1 Functions as a Tumor Suppressor in a Model of K-ras-Induced Pancreatic Ductal Adenocarcinoma. Hanlon L, etal., Cancer Res. 2010 May 18.
8. Total Flavonoids in Caragana (TFC) Promotes Angiogenesis and Enhances Cerebral Perfusion in a Rat Model of Ischemic Stroke. He Q, etal., Front Neurosci. 2018 Sep 12;12:635. doi: 10.3389/fnins.2018.00635. eCollection 2018.
9. Notch-1 activation and dendritic atrophy in prion disease. Ishikura N, etal., Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):886-91. doi: 10.1073/pnas.0408612101. Epub 2005 Jan 7.
10. Inducible nitric oxide synthase up-regulates Notch-1 in mouse cholangiocytes: implications for carcinogenesis. Ishimura N, etal., Gastroenterology. 2005 May;128(5):1354-68.
11. A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. Johnston SH, etal., Development 1997 Jun;124(11):2245-54.
12. Activation of Notch signaling in tumorigenesis of experimental pancreatic cancer induced by dimethylbenzanthracene in mice. Kimura K, etal., Cancer Sci. 2007 Feb;98(2):155-62.
13. Expression of Notch-1 and its ligand Jagged-1 in rat liver during liver regeneration. Kohler C, etal., Hepatology 2004 Apr;39(4):1056-65.
14. Arecoline N-oxide regulates oral squamous cell carcinoma development through NOTCH1 and FAT1 expressions. Kuo TM, etal., J Cell Physiol. 2019 Aug;234(8):13984-13993. doi: 10.1002/jcp.28084. Epub 2019 Jan 9.
15. Analysis of Molecular Mechanism of YiqiChutan Formula Regulating DLL4-Notch Signaling to Inhibit Angiogenesis in Lung Cancer. Li J, etal., Biomed Res Int. 2021 Feb 12;2021:8875503. doi: 10.1155/2021/8875503. eCollection 2021.
16. Xuan Bi Tong Yu Fang Promotes Angiogenesis via VEGF-Notch1/Dll4 Pathway in Myocardial Ischemic Rats. Li S, etal., Evid Based Complement Alternat Med. 2020 Feb 5;2020:5041629. doi: 10.1155/2020/5041629. eCollection 2020.
17. All-trans retinoid acid increases Notch1 transcript expression in acute promyelocytic leukemia. Lin JT, etal., Adv Ther. 2003 Nov-Dec;20(6):337-43.
18. Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes. Malecki MJ, etal., Mol Cell Biol. 2006 Jun;26(12):4642-51.
19. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
20. MGDs mouse GO annotations MGD data from the GO Consortium
21. MGD IEA MGD IEA
22. NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy. Miloudi K, etal., Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4538-4547. doi: 10.1073/pnas.1814711116. Epub 2019 Feb 20.
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. Sequential signaling through Notch1 and erbB receptors mediates radial glia differentiation. Patten BA, etal., J Neurosci 2003 Jul 9;23(14):6132-40.
25. Activation of multiple angiogenic signaling pathways in hemangiopericytoma. Pierscianek D, etal., Brain Tumor Pathol. 2016 Jul;33(3):200-8. doi: 10.1007/s10014-016-0256-6. Epub 2016 Mar 7.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
28. Si-Miao-Yong-An on promoting the maturation of Vasa Vasorum and stabilizing atherosclerotic plaque in ApoE-/- mice： An experimental study. Qi Z, etal., Biomed Pharmacother. 2019 Jun;114:108785. doi: 10.1016/j.biopha.2019.108785. Epub 2019 Mar 23.
29. Mouse MP Annotation Import Pipeline RGD automated import pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Downregulation of the endothelial genes Notch1 and ephrinB2 in patients with nodular regenerative hyperplasia. Rothweiler S, etal., Liver Int. 2014 Apr;34(4):594-603. doi: 10.1111/liv.12261. Epub 2013 Jul 21.
33. Gamma-Secretase Inhibitor, DAPT, Prevents the Development of Retinopathy of Prematurity in a Rat Model by Regulating the Delta-Like Ligand 4/Notch Homolog-1 (DLL4/Notch-1) Pathway. Sun W, etal., Med Sci Monit. 2019 Jan 17;25:492-499. doi: 10.12659/MSM.913828.
34. Imbalanced expression of TAN-1 and human Notch4 in endometrial cancers. Suzuki T, etal., Int J Oncol. 2000 Dec;17(6):1131-9.
35. Notch 1 and 3 receptor signaling modulates vascular smooth muscle cell growth, apoptosis, and migration via a CBF-1/RBP-Jk dependent pathway. Sweeney C, etal., FASEB J. 2004 Sep;18(12):1421-3. Epub 2004 Jul 9.
36. The role of HIF-1, angiopoietin-2, Dll4 and Notch1 in bleeding gastrointestinal vascular malformations and thalidomide-associated actions: a pilot in vivo study. Tan HH, etal., J Dig Dis. 2011 Oct;12(5):349-56. doi: 10.1111/j.1751-2980.2011.00506.x.
37. Down-regulation of the microRNAs miR-34a, miR-127, and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet. Tryndyak VP, etal., Mol Carcinog. 2009 Jun;48(6):479-87.
38. Reduced Notch1 Cleavage Promotes the Development of Pulmonary Hypertension. Wang S, etal., Hypertension. 2022 Jan;79(1):79-92. doi: 10.1161/HYPERTENSIONAHA.120.16065. Epub 2021 Nov 5.
39. Notch pathway is activated in cell culture and mouse models of mutant SOD1-related familial amyotrophic lateral sclerosis, with suppression of its activation as an additional mechanism of neuroprotection for lithium and valproate. Wang SY, etal., Neuroscience. 2015 Aug 20;301:276-88. doi: 10.1016/j.neuroscience.2015.06.002. Epub 2015 Jun 8.
40. Coordinate Notch3-hairy-related transcription factor pathway regulation in response to arterial injury. Mediator role of platelet-derived growth factor and ERK. Wang W, etal., J Biol Chem 2002 Jun 28;277(26):23165-71.
41. A homolog of Drosophila Notch expressed during mammalian development. Weinmaster G, etal., Development 1991 Sep;113(1):199-205.
42. Emodin alleviates hypertrophic scar formation by suppressing macrophage polarization and inhibiting the Notch and TGF-β pathways in macrophages. Xia Z, etal., Braz J Med Biol Res. 2021 Jul 23;54(8):e11184. doi: 10.1590/1414-431X2021e11184. eCollection 2021.
43. The expression levels of Notch-related signaling molecules in pulmonary microvascular endothelial cells in bleomycin-induced rat pulmonary fibrosis. Yin Q, etal., Physiol Res. 2017 May 4;66(2):305-315. doi: 10.33549/physiolres.933356. Epub 2016 Dec 16.
44. Activation of the Notch signaling pathway disturbs the CD4+/CD8+, Th17/Treg balance in rats with experimental autoimmune uveitis. Yin X, etal., Inflamm Res. 2019 Sep;68(9):761-774. doi: 10.1007/s00011-019-01260-w. Epub 2019 Jun 17.
45. Olmesartan attenuates cardiac remodeling through DLL4/Notch1 pathway activation in pressure overload mice. You J, etal., J Cardiovasc Pharmacol. 2013 Feb;61(2):142-51. doi: 10.1097/FJC.0b013e31827a0278.
46. Triggering of a Dll4-Notch1 loop impairs wound healing in diabetes. Zheng X, etal., Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6985-6994. doi: 10.1073/pnas.1900351116. Epub 2019 Mar 18.
47. Preventive effect of Notch signaling inhibition by a gamma-secretase inhibitor on peritoneal dialysis fluid-induced peritoneal fibrosis in rats. Zhu F, etal., Am J Pathol. 2010 Feb;176(2):650-9. Epub 2010 Jan 7.
48. NOTCH1 mutations in T-cell acute lymphoblastic leukemia: prognostic significance and implication in multifactorial leukemogenesis. Zhu YM, etal., Clin Cancer Res. 2006 May 15;12(10):3043-9.
Additional References at PubMed
PMID:1358459   PMID:1425352   PMID:1426644   PMID:7609614   PMID:7615640   PMID:7665181   PMID:7698746   PMID:7766993   PMID:7774911   PMID:7789282   PMID:7835890   PMID:7918097  
PMID:7926761   PMID:7956819   PMID:7956822   PMID:8075499   PMID:8088777   PMID:8217843   PMID:8440332   PMID:8449489   PMID:8486742   PMID:8597642   PMID:8645602   PMID:8661110  
PMID:8704256   PMID:8749394   PMID:8756350   PMID:8786137   PMID:8799160   PMID:8889548   PMID:8892234   PMID:8898100   PMID:8906418   PMID:8917536   PMID:8989517   PMID:8990127  
PMID:9011744   PMID:9102301   PMID:9108364   PMID:9111338   PMID:9153393   PMID:9169836   PMID:9189614   PMID:9242490   PMID:9291577   PMID:9315665   PMID:9334279   PMID:9374409  
PMID:9384671   PMID:9418910   PMID:9441674   PMID:9484841   PMID:9531541   PMID:9545534   PMID:9653148   PMID:9690472   PMID:9690473   PMID:9739106   PMID:9826771   PMID:9858718  
PMID:9858728   PMID:9882480   PMID:10080181   PMID:10090727   PMID:10194420   PMID:10205173   PMID:10206645   PMID:10330372   PMID:10349636   PMID:10367900   PMID:10383933   PMID:10393120  
PMID:10421573   PMID:10437788   PMID:10476967   PMID:10508694   PMID:10512199   PMID:10514008   PMID:10551863   PMID:10557086   PMID:10615124   PMID:10626888   PMID:10653853   PMID:10704869  
PMID:10704873   PMID:10712942   PMID:10734111   PMID:10745038   PMID:10747963   PMID:10748227   PMID:10804183   PMID:10821758   PMID:10825208   PMID:10837027   PMID:10837254   PMID:10839358  
PMID:10842072   PMID:10868931   PMID:10878608   PMID:10879540   PMID:10906448   PMID:10929049   PMID:10932180   PMID:10940313   PMID:10952889   PMID:10958687   PMID:10961893   PMID:11000255  
PMID:11042159   PMID:11044609   PMID:11044610   PMID:11044625   PMID:11076679   PMID:11076861   PMID:11095750   PMID:11118901   PMID:11120788   PMID:11124811   PMID:11133162   PMID:11156606  
PMID:11217851   PMID:11224523   PMID:11226752   PMID:11245412   PMID:11262239   PMID:11286731   PMID:11290335   PMID:11318877   PMID:11401408   PMID:11423996   PMID:11432830   PMID:11447280  
PMID:11459941   PMID:11466531   PMID:11475331   PMID:11504912   PMID:11518718   PMID:11532000   PMID:11562355   PMID:11578869   PMID:11581321   PMID:11585768   PMID:11641270   PMID:11713346  
PMID:11731257   PMID:11739954   PMID:11756438   PMID:11777909   PMID:11783997   PMID:11807030   PMID:11811553   PMID:11813235   PMID:11823505   PMID:11827460   PMID:11895769   PMID:11937492  
PMID:11944948   PMID:12001066   PMID:12032823   PMID:12050162   PMID:12121668   PMID:12123574   PMID:12135932   PMID:12165504   PMID:12167404   PMID:12175503   PMID:12185362   PMID:12186854  
PMID:12194867   PMID:12208538   PMID:12242712   PMID:12242716   PMID:12244553   PMID:12354787   PMID:12370315   PMID:12374741   PMID:12374742   PMID:12391150   PMID:12391611   PMID:12397111  
PMID:12411305   PMID:12421720   PMID:12441287   PMID:12459176   PMID:12466851   PMID:12477932   PMID:12479824   PMID:12486116   PMID:12509463   PMID:12520002   PMID:12538689   PMID:12588999  
PMID:12590261   PMID:12591596   PMID:12617809   PMID:12620991   PMID:12629177   PMID:12636920   PMID:12649319   PMID:12666205   PMID:12670869   PMID:12697902   PMID:12717450   PMID:12730124  
PMID:12734340   PMID:12753746   PMID:12759431   PMID:12783854   PMID:12794108   PMID:12807718   PMID:12815466   PMID:12829602   PMID:12842085   PMID:12846471   PMID:12860565   PMID:12866128  
PMID:12904583   PMID:12907456   PMID:12928374   PMID:12952904   PMID:12960086   PMID:12960155   PMID:12960312   PMID:12971992   PMID:14517990   PMID:14567994   PMID:14586790   PMID:14592976  
PMID:14595837   PMID:14597207   PMID:14641329   PMID:14645852   PMID:14651921   PMID:14657333   PMID:14672936   PMID:14701881   PMID:14702043   PMID:14732396   PMID:14745966   PMID:14757642  
PMID:14766969   PMID:14960276   PMID:14988227   PMID:14991602   PMID:15019995   PMID:15028713   PMID:15037549   PMID:15064243   PMID:15068794   PMID:15073150   PMID:15076712   PMID:15081359  
PMID:15082708   PMID:15084498   PMID:15107403   PMID:15155583   PMID:15156153   PMID:15162428   PMID:15187027   PMID:15198674   PMID:15226394   PMID:15226823   PMID:15237212   PMID:15251982  
PMID:15257302   PMID:15280211   PMID:15289495   PMID:15347683   PMID:15356142   PMID:15448134   PMID:15459106   PMID:15465493   PMID:15465494   PMID:15485896   PMID:15496460   PMID:15499562  
PMID:15509736   PMID:15525534   PMID:15529344   PMID:15531372   PMID:15543141   PMID:15545629   PMID:15550486   PMID:15563463   PMID:15574878   PMID:15576400   PMID:15598981   PMID:15625786  
PMID:15634680   PMID:15634701   PMID:15634911   PMID:15652348   PMID:15688350   PMID:15689374   PMID:15691760   PMID:15705961   PMID:15723439   PMID:15792957   PMID:15802643   PMID:15809373  
PMID:15821257   PMID:15854044   PMID:15857914   PMID:15866158   PMID:15866159   PMID:15875024   PMID:15879553   PMID:15882861   PMID:15882997   PMID:15897231   PMID:15902259   PMID:15905075  
PMID:15917835   PMID:15923152   PMID:15939383   PMID:15944289   PMID:15951812   PMID:15951813   PMID:15958385   PMID:15959516   PMID:15964998   PMID:15965470   PMID:15978571   PMID:15991363  
PMID:15994302   PMID:15998794   PMID:16000382   PMID:16024658   PMID:16056227   PMID:16061358   PMID:16107537   PMID:16120638   PMID:16141072   PMID:16141073   PMID:16141228   PMID:16145673  
PMID:16163386   PMID:16166587   PMID:16169548   PMID:16175584   PMID:16179393   PMID:16186384   PMID:16221173   PMID:16245338   PMID:16282337   PMID:16292344   PMID:16314491   PMID:16319921  
PMID:16324690   PMID:16332675   PMID:16354692   PMID:16360140   PMID:16365048   PMID:16407293   PMID:16412699   PMID:16420441   PMID:16434237   PMID:16434391   PMID:16452096   PMID:16467260  
PMID:16507912   PMID:16508302   PMID:16508303   PMID:16508306   PMID:16508308   PMID:16508312   PMID:16510501   PMID:16516838   PMID:16518823   PMID:16524929   PMID:16537572   PMID:16539652  
PMID:16543950   PMID:16554359   PMID:16554461   PMID:16602821   PMID:16607638   PMID:16618808   PMID:16622004   PMID:16651659   PMID:16678147   PMID:16680150   PMID:16690879   PMID:16699526  
PMID:16708386   PMID:16715081   PMID:16736472   PMID:16766699   PMID:16798735   PMID:16814577   PMID:16867989   PMID:16870249   PMID:16880393   PMID:16885355   PMID:16888092   PMID:16914494  
PMID:16954387   PMID:16966428   PMID:17015435   PMID:17015687   PMID:17021047   PMID:17028268   PMID:17070841   PMID:17074316   PMID:17079689   PMID:17080428   PMID:17111353   PMID:17123719  
PMID:17141159   PMID:17151017   PMID:17158336   PMID:17161657   PMID:17173050   PMID:17194759   PMID:17196193   PMID:17210915   PMID:17215306   PMID:17229764   PMID:17241776   PMID:17242367  
PMID:17257418   PMID:17259973   PMID:17261636   PMID:17273555   PMID:17274974   PMID:17296795   PMID:17303760   PMID:17306789   PMID:17311993   PMID:17318174   PMID:17319963   PMID:17320900  
PMID:17332426   PMID:17336907   PMID:17353266   PMID:17359917   PMID:17360776   PMID:17368826   PMID:17440974   PMID:17464091   PMID:17476283   PMID:17490632   PMID:17526737   PMID:17558399  
PMID:17572911   PMID:17573339   PMID:17573777   PMID:17585052   PMID:17599070   PMID:17605079   PMID:17611229   PMID:17636029   PMID:17658278   PMID:17658279   PMID:17664272   PMID:17664336  
PMID:17681135   PMID:17681139   PMID:17685488   PMID:17698635   PMID:17705199   PMID:17717603   PMID:17728344   PMID:17728348   PMID:17804806   PMID:17827153   PMID:17849441   PMID:17878313  
PMID:17880938   PMID:17881497   PMID:17898204   PMID:17915208   PMID:17928865   PMID:17948123   PMID:17967808   PMID:17981791   PMID:18024259   PMID:18048645   PMID:18049480   PMID:18077357  
PMID:18085664   PMID:18093989   PMID:18156632   PMID:18164701   PMID:18180377   PMID:18193087   PMID:18197263   PMID:18206867   PMID:18227520   PMID:18234727   PMID:18242220   PMID:18245384  
PMID:18283662   PMID:18287091   PMID:18287559   PMID:18292500   PMID:18297083   PMID:18299190   PMID:18299578   PMID:18311147   PMID:18332140   PMID:18347015   PMID:18351630   PMID:18353145  
PMID:18359890   PMID:18369158   PMID:18381292   PMID:18410734   PMID:18411251   PMID:18417619   PMID:18420737   PMID:18428029   PMID:18430783   PMID:18440314   PMID:18445292   PMID:18458114  
PMID:18458347   PMID:18467661   PMID:18471881   PMID:18483410   PMID:18485879   PMID:18495817   PMID:18505817   PMID:18507503   PMID:18528438   PMID:18547789   PMID:18550850   PMID:18552977  
PMID:18559979   PMID:18563491   PMID:18579680   PMID:18588871   PMID:18593982   PMID:18617694   PMID:18628966   PMID:18635581   PMID:18635610   PMID:18638478   PMID:18641686   PMID:18663146  
PMID:18665263   PMID:18666240   PMID:18667074   PMID:18676613   PMID:18677410   PMID:18694942   PMID:18708576   PMID:18758480   PMID:18777163   PMID:18798262   PMID:18799543   PMID:18799693  
PMID:18804439   PMID:18815281   PMID:18824585   PMID:18832397   PMID:18838555   PMID:18852283   PMID:18940734   PMID:18945887   PMID:18952909   PMID:18957219   PMID:18981238   PMID:18997111  
PMID:19000702   PMID:19001083   PMID:19011097   PMID:19023031   PMID:19059340   PMID:19064701   PMID:19084512   PMID:19087347   PMID:19103190   PMID:19107229   PMID:19109406   PMID:19110448  
PMID:19130928   PMID:19144989   PMID:19154718   PMID:19154719   PMID:19165340   PMID:19180482   PMID:19181188   PMID:19185577   PMID:19190337   PMID:19211676   PMID:19214430   PMID:19223466  
PMID:19228774   PMID:19245366   PMID:19250680   PMID:19251639   PMID:19265115   PMID:19290049   PMID:19296721   PMID:19332065   PMID:19339510   PMID:19349363   PMID:19369400   PMID:19369401  
PMID:19373512   PMID:19383720   PMID:19407245   PMID:19433083   PMID:19433762   PMID:19439425   PMID:19502490   PMID:19503073   PMID:19523851   PMID:19525946   PMID:19542352   PMID:19546852  
PMID:19564409   PMID:19567869   PMID:19571148   PMID:19573812   PMID:19590010   PMID:19598246   PMID:19605688   PMID:19620969   PMID:19652197   PMID:19660449   PMID:19662631   PMID:19666558  
PMID:19686682   PMID:19695258   PMID:19702084   PMID:19704010   PMID:19723505   PMID:19723774   PMID:19726682   PMID:19779553   PMID:19782673   PMID:19797679   PMID:19805515   PMID:19855010  
PMID:19859544   PMID:19895548   PMID:19897741   PMID:19898467   PMID:19914171   PMID:19914235   PMID:19915064   PMID:19945468   PMID:20007915   PMID:20017954   PMID:20048339   PMID:20059953  
PMID:20069650   PMID:20101599   PMID:20118921   PMID:20123092   PMID:20123979   PMID:20147635   PMID:20154142   PMID:20154720   PMID:20174635   PMID:20176991   PMID:20185432   PMID:20190740  
PMID:20194733   PMID:20335360   PMID:20335362   PMID:20339091   PMID:20346184   PMID:20346937   PMID:20351171   PMID:20356956   PMID:20363915   PMID:20371769   PMID:20375015   PMID:20378824  
PMID:20404113   PMID:20416178   PMID:20427764   PMID:20433915   PMID:20440271   PMID:20454918   PMID:20459529   PMID:20510365   PMID:20547764   PMID:20558824   PMID:20568246   PMID:20573072  
PMID:20610746   PMID:20624967   PMID:20627076   PMID:20628156   PMID:20628604   PMID:20648628   PMID:20685991   PMID:20696709   PMID:20711994   PMID:20727173   PMID:20739676   PMID:20740684  
PMID:20800279   PMID:20803506   PMID:20805882   PMID:20808958   PMID:20814569   PMID:20819091   PMID:20829372   PMID:20837470   PMID:20844195   PMID:20844536   PMID:20856205   PMID:20870902  
PMID:20870935   PMID:20889548   PMID:20890042   PMID:20930168   PMID:20935071   PMID:20935640   PMID:20940224   PMID:20947685   PMID:20975697   PMID:20978353   PMID:20979578   PMID:21042537  
PMID:21056041   PMID:21068062   PMID:21093322   PMID:21097675   PMID:21098559   PMID:21102556   PMID:21108929   PMID:21111839   PMID:21131365   PMID:21138975   PMID:21147753   PMID:21147849  
PMID:21147854   PMID:21149574   PMID:21156172   PMID:21156799   PMID:21167473   PMID:21189289   PMID:21191019   PMID:21194568   PMID:21203589   PMID:21205095   PMID:21205789   PMID:21205794  
PMID:21220737   PMID:21228373   PMID:21238454   PMID:21251092   PMID:21252157   PMID:21266774   PMID:21266778   PMID:21267068   PMID:21282722   PMID:21285514   PMID:21301413   PMID:21302255  
PMID:21305688   PMID:21308863   PMID:21311046   PMID:21315255   PMID:21319221   PMID:21321116   PMID:21321153   PMID:21330551   PMID:21349854   PMID:21352545   PMID:21356309   PMID:21379383  
PMID:21397841   PMID:21402699   PMID:21402740   PMID:21402782   PMID:21414292   PMID:21419176   PMID:21420948   PMID:21421844   PMID:21427293   PMID:21435444   PMID:21464222   PMID:21471203  
PMID:21471527   PMID:21478884   PMID:21493891   PMID:21498671   PMID:21503901   PMID:21527531   PMID:21531785   PMID:21559465   PMID:21562564   PMID:21571316   PMID:21572390   PMID:21598246  
PMID:21624358   PMID:21632822   PMID:21632926   PMID:21633169   PMID:21637838   PMID:21643850   PMID:21653327   PMID:21670468   PMID:21677750   PMID:21685328   PMID:21690374   PMID:21693515  
PMID:21700774   PMID:21712044   PMID:21723221   PMID:21730286   PMID:21731673   PMID:21731759   PMID:21737748   PMID:21737799   PMID:21750033   PMID:21750544   PMID:21757702   PMID:21761283  
PMID:21768299   PMID:21779394   PMID:21781958   PMID:21786021   PMID:21791528   PMID:21793101   PMID:21795391   PMID:21795743   PMID:21799763   PMID:21804540   PMID:21807868   PMID:21813561  
PMID:21827743   PMID:21829655   PMID:21832199   PMID:21836083   PMID:21839733   PMID:21841793   PMID:21852398   PMID:21869831   PMID:21873635   PMID:21909072   PMID:21943603   PMID:21943726  
PMID:21947280   PMID:21976438   PMID:21979816   PMID:21983003   PMID:21983543   PMID:21983868   PMID:21985982   PMID:21990372   PMID:21991352   PMID:21991375   PMID:21998026   PMID:22018469  
PMID:22031906   PMID:22037762   PMID:22065781   PMID:22077982   PMID:22086416   PMID:22096075   PMID:22100894   PMID:22109558   PMID:22110129   PMID:22110751   PMID:22117044   PMID:22146645  
PMID:22147266   PMID:22154818   PMID:22156581   PMID:22190634   PMID:22199353   PMID:22205705   PMID:22228100   PMID:22232070   PMID:22239539   PMID:22245843   PMID:22249198   PMID:22258620  
PMID:22274697   PMID:22279105   PMID:22323600   PMID:22330335   PMID:22331706   PMID:22355251   PMID:22360968   PMID:22364862   PMID:22366192   PMID:22390640   PMID:22393458   PMID:22396647  
PMID:22396766   PMID:22405651   PMID:22426001   PMID:22445366   PMID:22457635   PMID:22483937   PMID:22484060   PMID:22492969   PMID:22503540   PMID:22504165   PMID:22505716   PMID:22508726  
PMID:22509029   PMID:22510689   PMID:22514327   PMID:22522080   PMID:22536403   PMID:22554696   PMID:22586122   PMID:22610140   PMID:22615412   PMID:22629441   PMID:22640738   PMID:22652674  
PMID:22658935   PMID:22675208   PMID:22675211   PMID:22682244   PMID:22710872   PMID:22715413   PMID:22718343   PMID:22753939   PMID:22783020   PMID:22797898   PMID:22819676   PMID:22827997  
PMID:22837163   PMID:22851140   PMID:22854957   PMID:22865639   PMID:22865640   PMID:22899673   PMID:22907433   PMID:22915591   PMID:22932696   PMID:22951639   PMID:22954964   PMID:22955271  
PMID:22962329   PMID:22972921   PMID:22978624   PMID:22992387   PMID:23015591   PMID:23022658   PMID:23072809   PMID:23078884   PMID:23079658   PMID:23079659   PMID:23083737   PMID:23087364  
PMID:23095891   PMID:23103515   PMID:23111145   PMID:23115273   PMID:23129176   PMID:23132245   PMID:23134786   PMID:23136394   PMID:23160044   PMID:23162128   PMID:23166323   PMID:23178376  
PMID:23197537   PMID:23199335   PMID:23213461   PMID:23223237   PMID:23229232   PMID:23259928   PMID:23264614   PMID:23275471   PMID:23284756   PMID:23284900   PMID:23293291   PMID:23314057  
PMID:23319657   PMID:23335373   PMID:23350942   PMID:23359070   PMID:23362348   PMID:23377202   PMID:23378042   PMID:23382219   PMID:23386589   PMID:23386745   PMID:23389453   PMID:23391689  
PMID:23444353   PMID:23447065   PMID:23449471   PMID:23454273   PMID:23454750   PMID:23455394   PMID:23526493   PMID:23535650   PMID:23555292   PMID:23560082   PMID:23571217   PMID:23583836  
PMID:23585229   PMID:23589895   PMID:23604320   PMID:23614009   PMID:23615281   PMID:23615612   PMID:23630292   PMID:23630450   PMID:23657465   PMID:23665443   PMID:23666531   PMID:23671110  
PMID:23673656   PMID:23675950   PMID:23690447   PMID:23695674   PMID:23704950   PMID:23713656   PMID:23733784   PMID:23741415   PMID:23749646   PMID:23754280   PMID:23769842   PMID:23775085  
PMID:23776410   PMID:23785053   PMID:23791481   PMID:23806616   PMID:23813500   PMID:23818617   PMID:23824573   PMID:23824579   PMID:23825310   PMID:23830865   PMID:23832089   PMID:23841055  
PMID:23852537   PMID:23872918   PMID:23874882   PMID:23884415   PMID:23884446   PMID:23890069   PMID:23918982   PMID:23924630   PMID:23936265   PMID:23943799   PMID:23974200   PMID:23988635  
PMID:23989801   PMID:23999872   PMID:24015274   PMID:24023676   PMID:24048326   PMID:24068942   PMID:24073291   PMID:24074756   PMID:24145721   PMID:24148613   PMID:24151074   PMID:24153254  
PMID:24179156   PMID:24185616   PMID:24194600   PMID:24197755   PMID:24198274   PMID:24204826   PMID:24216479   PMID:24257627   PMID:24278323   PMID:24284009   PMID:24309499   PMID:24331925  
PMID:24335256   PMID:24337118   PMID:24353058   PMID:24360809   PMID:24368168   PMID:24376126   PMID:24391519   PMID:24398584   PMID:24424521   PMID:24449835   PMID:24453338   PMID:24476135  
PMID:24491691   PMID:24492617   PMID:24496616   PMID:24498290   PMID:24508387   PMID:24509876   PMID:24512687   PMID:24530424   PMID:24530429   PMID:24550118   PMID:24552588   PMID:24560643  
PMID:24573392   PMID:24583262   PMID:24583642   PMID:24631193   PMID:24633789   PMID:24637115   PMID:24647000   PMID:24659232   PMID:24667410   PMID:24673559   PMID:24711412   PMID:24715457  
PMID:24730386   PMID:24735465   PMID:24830414   PMID:24831012   PMID:24859004   PMID:24894949   PMID:24898819   PMID:24901044   PMID:24904084   PMID:24906372   PMID:24913005   PMID:24917500  
PMID:24927569   PMID:24950189   PMID:24952961   PMID:24974008   PMID:24982181   PMID:24988225   PMID:25003789   PMID:25004243   PMID:25005473   PMID:25017705   PMID:25038227   PMID:25038826  
PMID:25043004   PMID:25048699   PMID:25072663   PMID:25074942   PMID:25100656   PMID:25123309   PMID:25127056   PMID:25142465   PMID:25175815   PMID:25184679   PMID:25191221   PMID:25194570  
PMID:25196998   PMID:25203324   PMID:25203837   PMID:25234246   PMID:25299773   PMID:25318679   PMID:25332287   PMID:25342127   PMID:25344072   PMID:25344626   PMID:25344724   PMID:25344755  
PMID:25349182   PMID:25369933   PMID:25382630   PMID:25401743   PMID:25406379   PMID:25418579   PMID:25445276   PMID:25446530   PMID:25468943   PMID:25480918   PMID:25501905   PMID:25505333  
PMID:25516972   PMID:25522233   PMID:25535389   PMID:25535395   PMID:25535917   PMID:25546423   PMID:25574842   PMID:25596548   PMID:25607460   PMID:25641696   PMID:25641698   PMID:25678553  
PMID:25680284   PMID:25688859   PMID:25691540   PMID:25691658   PMID:25701255   PMID:25704809   PMID:25715395   PMID:25725069   PMID:25729925   PMID:25744722   PMID:25766473   PMID:25786100  
PMID:25798621   PMID:25805888   PMID:25813538   PMID:25825216   PMID:25830332   PMID:25835502   PMID:25845347   PMID:25848000   PMID:25866967   PMID:25916881   PMID:25919081   PMID:25982147  
PMID:25995356   PMID:26002917   PMID:26002977   PMID:26017770   PMID:26023079   PMID:26062937   PMID:26091508   PMID:26108693   PMID:26115479   PMID:26116661   PMID:26124113   PMID:26137442  
PMID:26176759   PMID:26188077   PMID:26191142   PMID:26198357   PMID:26204127   PMID:26249804   PMID:26253400   PMID:26271103   PMID:26276819   PMID:26293507   PMID:26294213   PMID:26303234  
PMID:26358219   PMID:26390244   PMID:26411367   PMID:26414444   PMID:26437242   PMID:26450967   PMID:26450968   PMID:26456319   PMID:26465397   PMID:26482652   PMID:26491108   PMID:26496195  
PMID:26499442   PMID:26503951   PMID:26507745   PMID:26522918   PMID:26522984   PMID:26552708   PMID:26552887   PMID:26563570   PMID:26598222   PMID:26620267   PMID:26628093   PMID:26635527  
PMID:26641715   PMID:26659946   PMID:26669487   PMID:26682927   PMID:26689676   PMID:26697723   PMID:26728556   PMID:26735577   PMID:26739565   PMID:26759236   PMID:26783939   PMID:26786165  
PMID:26791579   PMID:26800097   PMID:26811377   PMID:26828208   PMID:26837467   PMID:26843448   PMID:26857067   PMID:26858409   PMID:26870802   PMID:26876175   PMID:26880557   PMID:26911688  
PMID:26912775   PMID:26921468   PMID:26933171   PMID:26939553   PMID:26940862   PMID:26965898   PMID:26999738   PMID:26999814   PMID:27015742   PMID:27025873   PMID:27040987   PMID:27056911  
PMID:27074663   PMID:27084580   PMID:27099134   PMID:27107132   PMID:27112428   PMID:27122169   PMID:27129289   PMID:27141930   PMID:27146698   PMID:27173138   PMID:27184845   PMID:27224017  
PMID:27267497   PMID:27271278   PMID:27294523   PMID:27343556   PMID:27348588   PMID:27354212   PMID:27354375   PMID:27364009   PMID:27428080   PMID:27435629   PMID:27447294   PMID:27510977  
PMID:27524235   PMID:27525720   PMID:27537524   PMID:27542621   PMID:27564256   PMID:27564686   PMID:27573812   PMID:27576369   PMID:27600720   PMID:27631609   PMID:27633993   PMID:27639164  
PMID:27641601   PMID:27644105   PMID:27670423   PMID:27680314   PMID:27697822   PMID:27698445   PMID:27698452   PMID:27705795   PMID:27707753   PMID:27719760   PMID:27734842   PMID:27736875  
PMID:27776108   PMID:27791012   PMID:27809299   PMID:27813493   PMID:27821476   PMID:27875565   PMID:27909050   PMID:27913625   PMID:27924849   PMID:27930960   PMID:27939883   PMID:27941799  
PMID:27966429   PMID:27991863   PMID:28009085   PMID:28027303   PMID:28067668   PMID:28089369   PMID:28099888   PMID:28158917   PMID:28192800   PMID:28207192   PMID:28215559   PMID:28248965  
PMID:28263185   PMID:28266574   PMID:28272472   PMID:28286920   PMID:28346225   PMID:28347224   PMID:28377411   PMID:28384643   PMID:28385530   PMID:28395734   PMID:28401892   PMID:28402857  
PMID:28423318   PMID:28438836   PMID:28455376   PMID:28455378   PMID:28489825   PMID:28498977   PMID:28530678   PMID:28538179   PMID:28561022   PMID:28562688   PMID:28577314   PMID:28581022  
PMID:28600728   PMID:28606953   PMID:28611114   PMID:28619820   PMID:28637464   PMID:28637720   PMID:28650075   PMID:28656980   PMID:28669409   PMID:28674041   PMID:28685750   PMID:28698260  
PMID:28714968   PMID:28745029   PMID:28751525   PMID:28762472   PMID:28765900   PMID:28781077   PMID:28808228   PMID:28816361   PMID:28863329   PMID:28871079   PMID:28916710   PMID:28924218  
PMID:28931948   PMID:28932899   PMID:28939651   PMID:28939843   PMID:28974640   PMID:28993437   PMID:29024000   PMID:29031500   PMID:29037878   PMID:29042443   PMID:29049420   PMID:29073101  
PMID:29086765   PMID:29093270   PMID:29095923   PMID:29098541   PMID:29113990   PMID:29138297   PMID:29139178   PMID:29140246   PMID:29140985   PMID:29158473   PMID:29169413   PMID:29184052  
PMID:29186476   PMID:29188781   PMID:29198823   PMID:29228365   PMID:29234016   PMID:29247167   PMID:29286081   PMID:29301578   PMID:29307821   PMID:29337306   PMID:29345116   PMID:29352015  
PMID:29371425   PMID:29386140   PMID:29395868   PMID:29398116   PMID:29398135   PMID:29422515   PMID:29449332   PMID:29458175   PMID:29481785   PMID:29496446   PMID:29507213   PMID:29513653  
PMID:29515034   PMID:29545603   PMID:29688375   PMID:29689424   PMID:29727635   PMID:29739871   PMID:29743679   PMID:29784917   PMID:29807327   PMID:29853617   PMID:29885287   PMID:29887318  
PMID:29891551   PMID:29895619   PMID:29897330   PMID:29951922   PMID:29956664   PMID:29961574   PMID:29981303   PMID:30010003   PMID:30018219   PMID:30025440   PMID:30036609   PMID:30059908  
PMID:30061196   PMID:30076146   PMID:30084950   PMID:30103197   PMID:30181175   PMID:30188892   PMID:30201295   PMID:30201687   PMID:30220568   PMID:30226866   PMID:30244870   PMID:30260951  
PMID:30266659   PMID:30273359   PMID:30279738   PMID:30289388   PMID:30312604   PMID:30323897   PMID:30337536   PMID:30347193   PMID:30428088   PMID:30448061   PMID:30485816   PMID:30487608  
PMID:30488216   PMID:30514723   PMID:30565678   PMID:30582451   PMID:30590051   PMID:30596653   PMID:30598546   PMID:30692224   PMID:30696875   PMID:30778241   PMID:30843783   PMID:30902967  
PMID:30932281   PMID:30941836   PMID:30951556   PMID:30958266   PMID:30974486   PMID:31020645   PMID:31071093   PMID:31112136   PMID:31118412   PMID:31129659   PMID:31142802   PMID:31155355  
PMID:31189722   PMID:31202705   PMID:31220272   PMID:31226309   PMID:31249304   PMID:31266349   PMID:31340161   PMID:31412250   PMID:31420575   PMID:31434798   PMID:31450635   PMID:31471323  
PMID:31481792   PMID:31504280   PMID:31562298   PMID:31564613   PMID:31578237   PMID:31590629   PMID:31591643   PMID:31598881   PMID:31631837   PMID:31636950   PMID:31712410   PMID:31758376  
PMID:31789590   PMID:31825833   PMID:31870258   PMID:31886826   PMID:31988190   PMID:32043969   PMID:32059775   PMID:32060138   PMID:32141629   PMID:32147304   PMID:32161758   PMID:32170006  
PMID:32171747   PMID:32201074   PMID:32255764   PMID:32332750   PMID:32423029   PMID:32454795   PMID:32467237   PMID:32467240   PMID:32484440   PMID:32507875   PMID:32529705   PMID:32531190  
PMID:32546759   PMID:32582141   PMID:32655758   PMID:32715474   PMID:32747435   PMID:32756905   PMID:32820046   PMID:32871474   PMID:32924017   PMID:32929274   PMID:32991757   PMID:33012268  
PMID:33017398   PMID:33046701   PMID:33046710   PMID:33053343   PMID:33109684   PMID:33148887   PMID:33189893   PMID:33195274   PMID:33210601   PMID:33227706   PMID:33237915   PMID:33284968  
PMID:33303684   PMID:33309869   PMID:33314197   PMID:33315499   PMID:33332551   PMID:33371813   PMID:33435713   PMID:33441309   PMID:33590845   PMID:33608670   PMID:33622250   PMID:33637728  
PMID:33655333   PMID:33657078   PMID:33673337   PMID:33675998   PMID:33730615   PMID:33830085   PMID:33846290   PMID:33892704   PMID:33898448   PMID:33915108   PMID:33956260   PMID:34004439  
PMID:34099102   PMID:34107249   PMID:34257546   PMID:34278466   PMID:34320265   PMID:34321999   PMID:34389314   PMID:34408185   PMID:34463756   PMID:34475389   PMID:34487959   PMID:34504875  
PMID:34519339   PMID:34519870   PMID:34571841   PMID:34665379   PMID:34667084   PMID:34671097   PMID:34686881   PMID:34698766   PMID:34726809   PMID:34737300   PMID:34757798   PMID:34824237  
PMID:34838591   PMID:34854382   PMID:34921404   PMID:34998785   PMID:35013223   PMID:35020836   PMID:35064244   PMID:35084365   PMID:35103284   PMID:35126469   PMID:35211114   PMID:35247391  
PMID:35263603   PMID:35273151   PMID:35297995   PMID:35303432   PMID:35318267   PMID:35349492   PMID:35429490   PMID:35448087   PMID:35508126   PMID:35521669   PMID:35575074   PMID:35617425  
PMID:35623385   PMID:35652338   PMID:35682851   PMID:35781337   PMID:35803280   PMID:35815610   PMID:35821235   PMID:35831318   PMID:35832093   PMID:35906071   PMID:35942101   PMID:36006534  
PMID:36064547   PMID:36082581   PMID:36183290   PMID:36218069   PMID:36239412   PMID:36253375   PMID:36273888   PMID:36316479   PMID:36325906   PMID:36376768   PMID:36414704   PMID:36418183  
PMID:36456828   PMID:36580262   PMID:36657722   PMID:36658434   PMID:36672468   PMID:36706917   PMID:36797416   PMID:36834623   PMID:36840628   PMID:36899896   PMID:36973704   PMID:37023750  
PMID:37068229   PMID:37168577   PMID:37249327   PMID:37260223   PMID:37272771   PMID:37317851   PMID:37329502   PMID:37330998   PMID:37338984   PMID:37369584   PMID:37385754   PMID:37414855  
PMID:37494420   PMID:37555328   PMID:37573008   PMID:37632963   PMID:37669937   PMID:37702066   PMID:37723064   PMID:37818607   PMID:37921375   PMID:38018454   PMID:38029793   PMID:38095642  
PMID:38111957   PMID:38149979   PMID:38284891   PMID:38289520   PMID:38345319   PMID:38355793   PMID:38374152   PMID:38383534   PMID:38512983   PMID:38538986   PMID:38582368   PMID:38603632  
PMID:38653356   PMID:38669183   PMID:38720211   PMID:38772376   PMID:38794925   PMID:38850155   PMID:38891776   PMID:38944331   PMID:39079536   PMID:39113792   PMID:39122845   PMID:39190102  
PMID:39271675   PMID:39303845   PMID:39313617   PMID:39315665   PMID:39390606   PMID:39437002   PMID:39550366   PMID:39612246   PMID:39671488   PMID:39699962   PMID:39746830   PMID:39779370  
PMID:39932433   PMID:40079140   PMID:40163542  


Genomics

Comparative Map Data
Notch1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39226,347,914 - 26,393,834 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl226,347,915 - 26,406,675 (-)EnsemblGRCm39 Ensembl
GRCm38226,457,902 - 26,503,822 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl226,457,903 - 26,516,663 (-)EnsemblGRCm38mm10GRCm38
MGSCv37226,313,422 - 26,359,342 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36226,280,033 - 26,325,646 (-)NCBIMGSCv36mm8
Celera226,175,736 - 26,221,759 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map218.91NCBI
NOTCH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389136,494,433 - 136,546,048 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9136,494,433 - 136,546,048 (-)EnsemblGRCh38hg38GRCh38
GRCh379139,388,885 - 139,440,500 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369138,508,717 - 138,560,059 (-)NCBINCBI36Build 36hg18NCBI36
Build 349136,664,733 - 136,716,075NCBI
Celera9109,903,340 - 109,955,631 (-)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9108,848,155 - 108,928,442 (-)NCBIHuRef
CHM1_19139,537,630 - 139,588,846 (-)NCBICHM1_1
T2T-CHM13v2.09148,723,532 - 148,777,907 (-)NCBIT2T-CHM13v2.0
Notch1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8329,676,040 - 29,721,613 (-)NCBIGRCr8
GRCr8 Ensembl329,676,171 - 29,721,613 (-)EnsemblGRCr8 Ensembl
mRatBN7.239,277,955 - 9,323,531 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl39,278,086 - 9,323,531 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx312,332,077 - 12,388,087 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0320,915,306 - 20,971,319 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0319,170,646 - 19,226,660 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.033,905,562 - 3,951,015 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl33,905,453 - 3,951,025 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.039,266,663 - 9,311,575 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.434,631,797 - 4,677,640 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera34,097,915 - 4,143,369 (-)NCBICelera
RGSC_v3.134,632,997 - 4,677,652 (-)NCBI
Cytogenetic Map3p13NCBI
Notch1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555134,225,956 - 4,263,259 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555134,225,939 - 4,264,875 (+)NCBIChiLan1.0ChiLan1.0
NOTCH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2112,838,339 - 2,890,794 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan192,840,674 - 2,893,129 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09107,568,670 - 107,621,032 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19136,544,639 - 136,595,511 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9136,544,639 - 136,598,740 (-)Ensemblpanpan1.1panPan2
NOTCH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,975,972 - 49,018,985 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,974,757 - 49,017,277 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha948,226,361 - 48,269,900 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,852,205 - 49,895,734 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,851,628 - 49,894,186 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,633,237 - 48,676,758 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,926,759 - 48,970,231 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,974,423 - 49,017,941 (+)NCBIUU_Cfam_GSD_1.0
Notch1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,040,997 - 202,083,042 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366691,292,088 - 1,332,428 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366691,292,016 - 1,334,061 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOTCH1
(Sus scrofa - pig)		 No map positions available.
NOTCH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,656,815 - 1,707,566 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,656,918 - 1,709,585 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660583,509,673 - 3,610,304 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Notch1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247601,634,702 - 1,676,531 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247601,636,331 - 1,676,398 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Notch1
2118 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:2400
Count of miRNA genes:746
Interacting mature miRNAs:950
Transcripts:ENSMUST00000028288, ENSMUST00000123873, ENSMUST00000126872, ENSMUST00000129506, ENSMUST00000131393, ENSMUST00000132820, ENSMUST00000132941, ENSMUST00000138034, ENSMUST00000140082, ENSMUST00000147481, ENSMUST00000148948
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552706Cia24_mcollagen induced arthritis QTL 24 (mouse)Not determined22467911533523172Mouse
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212953766556453Mouse
1300624Insq7_minsulin QTL 7 (mouse)Not determined2938444643384575Mouse
8552705Cia25_mcollagen induced arthritis 25 (mouse)Not determined22467911533523172Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
26884438Sklq12_mskull length QTL 12, 16 week (mouse)22459001254890012Mouse
1301790Pcfm1_mperiosteal circumference and femur length 1 (mouse)Not determined2823629642236396Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
4142130Pgis2_mproteoglycan induced spondylitis 2 (mouse)Not determined22530805156971811Mouse
1301980Fcsa5_mfemoral cross-sectional area 5 (mouse)Not determined2767911541679261Mouse
1301376Etohc1_methanol consumption 1 (mouse)Not determined22112972555129871Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
12792980Fbmd1_mfemoral bone mineral density 1, females only (mouse)22503449245034492Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1301641Sbmd2_mspinal bone mineral density 2 (mouse)Not determined21421456748214713Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
1301838Sluc16_msusceptibility to lung cancer 16 (mouse)Not determined2126529589Mouse
10755513Amzn4_manatomical modifier of Zfp423 4 (mouse)2938444643384575Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
12904743Carcdq3_mcardiac collagen deposition QTL 3 (mouse)2323494028179150Mouse
13463470Tubisq1_mtubulointerstitial injury severity, QTL 1 (mouse)22368914557689269Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
4141708Pbwg1.2_mpostnatal body weight growth 1.2 (mouse)Not determined2112972555129871Mouse
10043876Adip22_madiposity 22 (mouse)Not determined2830805142308240Mouse
12903993Opfaq1_mopen field activity QTL 1 (mouse)2967669127022642Mouse

Markers in Region
Notch1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38226,458,252 - 26,459,242UniSTSGRCm38
MGSCv37226,313,772 - 26,314,762UniSTSGRCm37
Celera226,176,086 - 26,177,076UniSTS
Cytogenetic Map2A3UniSTS
cM Map215.0UniSTS
cM Map215.0UniSTS
D2Mit151  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38226,494,434 - 26,494,563UniSTSGRCm38
MGSCv37226,349,954 - 26,350,083UniSTSGRCm37
Celera226,212,369 - 26,212,502UniSTS
Cytogenetic Map2A3UniSTS
cM Map215.0UniSTS
Whitehead Genetic220.8UniSTS
Whitehead/MRC_RH2453.92UniSTS
RH134624  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38226,459,467 - 26,459,646UniSTSGRCm38
MGSCv37226,314,987 - 26,315,166UniSTSGRCm37
Celera226,177,301 - 26,177,480UniSTS
Cytogenetic Map2A3UniSTS
cM Map215.0UniSTS
PMC85812P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38226,465,065 - 26,465,433UniSTSGRCm38
MGSCv37226,320,585 - 26,320,953UniSTSGRCm37
Celera226,182,899 - 26,183,267UniSTS
Cytogenetic Map2A3UniSTS
cM Map215.0UniSTS
Notch1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38226,468,368 - 26,469,911UniSTSGRCm38
MGSCv37226,323,888 - 26,325,431UniSTSGRCm37
Celera226,186,202 - 26,187,745UniSTS
Cytogenetic Map2A3UniSTS
Notch1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2A3UniSTS
Notch1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38226,460,921 - 26,462,218UniSTSGRCm38
MGSCv37226,316,441 - 26,317,738UniSTSGRCm37
Celera226,178,755 - 26,180,052UniSTS
Cytogenetic Map2A3UniSTS
Notch1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38226,463,929 - 26,464,896UniSTSGRCm38
MGSCv37226,319,449 - 26,320,416UniSTSGRCm37
Celera226,181,763 - 26,182,730UniSTS
Cytogenetic Map2A3UniSTS
cM Map215.0UniSTS
Notch1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38226,459,283 - 26,459,488UniSTSGRCm38
MGSCv37226,314,803 - 26,315,008UniSTSGRCm37
Celera226,177,117 - 26,177,322UniSTS
Cytogenetic Map2A3UniSTS
cM Map215.0UniSTS
Notch1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38226,460,744 - 26,460,935UniSTSGRCm38
MGSCv37226,316,264 - 26,316,455UniSTSGRCm37
Celera226,178,578 - 26,178,769UniSTS
Cytogenetic Map2A3UniSTS
Notch1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2A3UniSTS
Notch1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2A3UniSTS
Notch1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2A3UniSTS
cM Map215.0UniSTS
Notch1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38226,459,604 - 26,459,850UniSTSGRCm38
MGSCv37226,315,124 - 26,315,370UniSTSGRCm37
Celera226,177,438 - 26,177,684UniSTS
Cytogenetic Map2A3UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB100603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB100875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB100878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB100879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB101624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB101625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB101626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB101627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB101628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB101629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB101630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB101631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB101632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB101633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB101634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB101636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB101637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB104428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB104448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB104455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB104459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF508809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ238029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK042197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK054089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK079454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK090118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL732541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF318436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY233933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS419139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L02613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X68278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X82562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z11886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z21925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000028288   ⟹   ENSMUSP00000028288
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,347,915 - 26,393,834 (-)Ensembl
GRCm38.p6 Ensembl226,457,903 - 26,503,822 (-)Ensembl
Ensembl Acc Id: ENSMUST00000123873
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,358,555 - 26,359,761 (-)Ensembl
GRCm38.p6 Ensembl226,468,543 - 26,469,749 (-)Ensembl
Ensembl Acc Id: ENSMUST00000126872
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,355,483 - 26,356,666 (-)Ensembl
GRCm38.p6 Ensembl226,465,471 - 26,466,654 (-)Ensembl
Ensembl Acc Id: ENSMUST00000129506
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,359,837 - 26,360,510 (-)Ensembl
GRCm38.p6 Ensembl226,469,825 - 26,470,498 (-)Ensembl
Ensembl Acc Id: ENSMUST00000131393
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,388,167 - 26,393,836 (-)Ensembl
GRCm38.p6 Ensembl226,498,155 - 26,503,824 (-)Ensembl
Ensembl Acc Id: ENSMUST00000132820   ⟹   ENSMUSP00000115258
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,361,288 - 26,406,675 (-)Ensembl
GRCm38.p6 Ensembl226,471,276 - 26,516,663 (-)Ensembl
Ensembl Acc Id: ENSMUST00000132941
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,352,230 - 26,352,759 (-)Ensembl
GRCm38.p6 Ensembl226,462,218 - 26,462,747 (-)Ensembl
Ensembl Acc Id: ENSMUST00000138034
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,355,483 - 26,356,379 (-)Ensembl
GRCm38.p6 Ensembl226,465,471 - 26,466,367 (-)Ensembl
Ensembl Acc Id: ENSMUST00000140082
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,355,483 - 26,356,806 (-)Ensembl
GRCm38.p6 Ensembl226,465,471 - 26,466,794 (-)Ensembl
Ensembl Acc Id: ENSMUST00000147481
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,355,483 - 26,357,625 (-)Ensembl
GRCm38.p6 Ensembl226,465,471 - 26,467,613 (-)Ensembl
Ensembl Acc Id: ENSMUST00000148948
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,355,483 - 26,356,175 (-)Ensembl
GRCm38.p6 Ensembl226,465,471 - 26,466,163 (-)Ensembl
RefSeq Acc Id: NM_008714   ⟹   NP_032740
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39226,347,914 - 26,393,834 (-)NCBI
GRCm38226,457,902 - 26,503,822 (-)ENTREZGENE
MGSCv37226,313,422 - 26,359,342 (-)RGD
Celera226,175,736 - 26,221,759 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032740   ⟸   NM_008714
- Peptide Label: precursor
- UniProtKB: Q9QW58 (UniProtKB/Swiss-Prot),   Q99JC2 (UniProtKB/Swiss-Prot),   Q8K428 (UniProtKB/Swiss-Prot),   Q7TQ52 (UniProtKB/Swiss-Prot),   Q7TQ51 (UniProtKB/Swiss-Prot),   Q7TQ50 (UniProtKB/Swiss-Prot),   Q61905 (UniProtKB/Swiss-Prot),   Q3U3Y2 (UniProtKB/Swiss-Prot),   Q3TZW2 (UniProtKB/Swiss-Prot),   Q06007 (UniProtKB/Swiss-Prot),   Q9R0X7 (UniProtKB/Swiss-Prot),   Q01705 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000115258   ⟸   ENSMUST00000132820
Ensembl Acc Id: ENSMUSP00000028288   ⟸   ENSMUST00000028288
Protein Domains
EGF-like   Notch C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q01705-F1-model_v2 AlphaFold Q01705 1-2531 view protein structure

Promoters
RGD ID:6831933
Promoter ID:MM_KWN:28281
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   Spleen
Transcripts:OTTMUST00000030666
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36226,317,831 - 26,319,262 (-)MPROMDB
RGD ID:6831930
Promoter ID:MM_KWN:28282
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Lung
Transcripts:OTTMUST00000030662,   OTTMUST00000030663,   UC008IVM.1,   UC008IVN.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36226,322,176 - 26,323,252 (-)MPROMDB
RGD ID:6831931
Promoter ID:MM_KWN:28283
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Lung
Transcripts:OTTMUST00000030659
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36226,323,336 - 26,324,082 (-)MPROMDB
RGD ID:6831934
Promoter ID:MM_KWN:28284
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Lung
Transcripts:OTTMUST00000030665
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36226,325,026 - 26,326,142 (-)MPROMDB
RGD ID:6831936
Promoter ID:MM_KWN:28285
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Liver,   Lung,   Spleen
Transcripts:UC008IVO.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36226,325,976 - 26,326,627 (-)MPROMDB
RGD ID:6848752
Promoter ID:MM_TRO:5353
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:MTR000375.2.524.2
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36226,333,361 - 26,333,861 (-)MPROMDB
RGD ID:6849116
Promoter ID:MM_XEF:3895
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Liver,   Lung
Transcripts:NM_001087605,   NM_001097288,   NM_001135695
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36226,357,401 - 26,357,977 (-)MPROMDB
RGD ID:6831929
Promoter ID:MM_KWN:28286
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000102908,   NM_008714,   OTTMUST00000030664
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36226,359,226 - 26,360,242 (-)MPROMDB
RGD ID:6876704
Promoter ID:EPDNEW_M1803
Type:multiple initiation site
Name:Notch1_1
Description:Mus musculus notch 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38226,503,824 - 26,503,884EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97363 AgrOrtholog
Ensembl Genes ENSMUSG00000026923 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000028288 ENTREZGENE
  ENSMUST00000028288.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot
  3.30.300.320 UniProtKB/Swiss-Prot
  3.30.70.3310 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
  DUF3454_notch UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_CS UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  Notch UniProtKB/Swiss-Prot
  Notch-like_dom_sf UniProtKB/Swiss-Prot
  Notch/Slit_guidance UniProtKB/Swiss-Prot
  NOTCH1_EGF-like UniProtKB/Swiss-Prot
  Notch_1 UniProtKB/Swiss-Prot
  Notch_dom UniProtKB/Swiss-Prot
  Notch_NOD_dom UniProtKB/Swiss-Prot
  Notch_NODP_dom UniProtKB/Swiss-Prot
KEGG Report mmu:18128 UniProtKB/Swiss-Prot
MGD MGI:97363 ENTREZGENE
NCBI Gene 18128 ENTREZGENE
PANTHER NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1 UniProtKB/Swiss-Prot
  SLIT HOMOLOG UniProtKB/Swiss-Prot
Pfam Ank UniProtKB/Swiss-Prot
  Ank_2 UniProtKB/Swiss-Prot
  EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  hEGF UniProtKB/Swiss-Prot
  NOD UniProtKB/Swiss-Prot
  NODP UniProtKB/Swiss-Prot
  Notch UniProtKB/Swiss-Prot
PhenoGen Notch1 PhenoGen
PIRSF Notch UniProtKB/Swiss-Prot
PRINTS LNOTCHREPEAT UniProtKB/Swiss-Prot
  NOTCH UniProtKB/Swiss-Prot
  NOTCH1 UniProtKB/Swiss-Prot
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot
  ASX_HYDROXYL UniProtKB/Swiss-Prot
  EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  LNR UniProtKB/Swiss-Prot
SMART ANK UniProtKB/Swiss-Prot
  DUF3454 UniProtKB/Swiss-Prot
  EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  NOD UniProtKB/Swiss-Prot
  NODP UniProtKB/Swiss-Prot
  SM00004 UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  SSF48403 UniProtKB/Swiss-Prot
  SSF57184 UniProtKB/Swiss-Prot
  SSF90193 UniProtKB/Swiss-Prot
UniProt A2AIX5_MOUSE UniProtKB/TrEMBL
  NOTC1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q06007 ENTREZGENE
  Q3TZW2 ENTREZGENE
  Q3U3Y2 ENTREZGENE
  Q61905 ENTREZGENE
  Q7TQ50 ENTREZGENE
  Q7TQ51 ENTREZGENE
  Q7TQ52 ENTREZGENE
  Q8BY39_MOUSE UniProtKB/TrEMBL
  Q8K428 ENTREZGENE
  Q99JC2 ENTREZGENE
  Q9QW58 ENTREZGENE
  Q9R0X7 ENTREZGENE
UniProt Secondary Q06007 UniProtKB/Swiss-Prot
  Q3TZW2 UniProtKB/Swiss-Prot
  Q3U3Y2 UniProtKB/Swiss-Prot
  Q61905 UniProtKB/Swiss-Prot
  Q7TQ50 UniProtKB/Swiss-Prot
  Q7TQ51 UniProtKB/Swiss-Prot
  Q7TQ52 UniProtKB/Swiss-Prot
  Q8K428 UniProtKB/Swiss-Prot
  Q99JC2 UniProtKB/Swiss-Prot
  Q9QW58 UniProtKB/Swiss-Prot
  Q9R0X7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-05 Notch1  notch 1  Notch1  Notch gene homolog 1 (Drosophila)  Symbol and/or name change 5135510 APPROVED