Notch1 (notch 1) - Rat Genome Database

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Gene: Notch1 (notch 1) Mus musculus
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Symbol: Notch1
Name: notch 1
RGD ID: 10998
MGI Page MGI
Description: Enables several functions, including Notch binding activity; transcription coactivator activity; and transcription regulator activator activity. Involved in several processes, including circulatory system development; negative regulation of cell differentiation; and regulation of BMP signaling pathway. Acts upstream of or within several processes, including circulatory system development; epithelial cell differentiation; and regulation of epithelial cell differentiation. Located in several cellular components, including adherens junction; apical plasma membrane; and cell surface. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia/lymphoma; aortic valve disease 1; and congenital heart disease. Orthologous to human NOTCH1 (notch receptor 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9930111A19Rik; lin; lin-12; major type A protein; Mi; Mis6; Motch A; mT14; N; N1; neurogenic locus notch homolog protein 1; Notch gene homolog 1; p300; Ta; Tan1; transmembrane receptor Notch1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39226,347,914 - 26,393,834 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl226,347,915 - 26,406,675 (-)EnsemblGRCm39 Ensembl
GRCm38226,457,902 - 26,503,822 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl226,457,903 - 26,516,663 (-)EnsemblGRCm38mm10GRCm38
MGSCv37226,313,422 - 26,359,342 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36226,280,033 - 26,325,646 (-)NCBIMGSCv36mm8
Celera226,175,736 - 26,221,759 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map218.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Adams-Oliver syndrome  (ISO)
Adams-Oliver Syndrome 2  (ISO)
Adams-Oliver Syndrome 5  (ISO)
adenoid cystic carcinoma  (ISO)
adenoiditis  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
amyotrophic lateral sclerosis  (IEP)
aortic valve disease  (ISO)
aortic valve disease 1  (ISO)
ARTERIAL DISSECTION  (ISO)
atherosclerosis  (IEP)
autism spectrum disorder  (ISO)
autosomal dominant intellectual developmental disorder 8  (ISO)
autosomal dominant nocturnal frontal lobe epilepsy 5  (ISO)
bicuspid aortic valve disease  (ISO)
Breast Neoplasms  (ISO)
Calcification of Aortic Valve  (ISO)
calcinosis  (ISO)
Cardiomegaly  (IEP)
Cardiovascular Abnormalities  (ISO)
Carotid Artery Injuries  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholangiocarcinoma  (ISO)
cholesteatoma of middle ear  (ISO)
Colonic Neoplasms  (ISO)
Congenital Abnormalities  (ISO)
congenital heart disease  (ISO)
congenital muscular dystrophy  (ISO)
connective tissue disease  (ISO)
Craniofacial Abnormalities  (ISO)
developmental and epileptic encephalopathy 14  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Foot  (ISO)
diabetic retinopathy  (IMP)
Ehlers-Danlos syndrome classic type 1  (ISO)
Ehlers-Danlos syndrome hypermobility type  (ISO)
endometrial cancer  (ISO)
epilepsy  (ISO)
esophageal atresia  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Liver Neoplasms  (ISO)
Focal Nodular Hyperplasia  (ISO)
Folate-Responsive Megaloblastic Anemia  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
heart valve disease  (ISO)
hemangioma  (ISO)
hemangiopericytoma  (ISO)
hypoplastic left heart syndrome  (ISO)
Joubert syndrome 1  (ISO)
keratoacanthoma  (ISO)
Kleefstra syndrome 1  (ISO)
Leigh disease  (ISO)
lung adenocarcinoma  (ISO)
lung large cell carcinoma  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lymphoma  (ISO)
malignant astrocytoma  (ISO)
Marfan syndrome  (ISO)
Marfanoid Hypermobility Syndrome  (ISO)
microphthalmia  (ISO)
myeloproliferative neoplasm  (ISO)
Myocardial Ischemia  (ISO)
Neoplastic Cell Transformation  (ISO)
nervous system disease  (ISO)
oral squamous cell carcinoma  (IEP)
pancreatic cancer  (IMP)
pancreatic ductal carcinoma  (IMP,ISO)
Peritoneal Diseases  (ISO)
primary coenzyme Q10 deficiency 7  (ISO)
prion disease  (IEP)
Pulmonary Arterial Hypertension  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (IDA)
Rafiq syndrome  (ISO)
retinopathy of prematurity  (ISO)
scoliosis  (ISO)
SHONE COMPLEX  (ISO)
Skin Neoplasms  (ISO)
Splenomegaly  (ISO)
squamous cell carcinoma  (ISO)
Surgical Wound  (IMP)
syndromic microphthalmia 5  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
tetralogy of Fallot  (ISO)
thoracic aortic aneurysm  (ISO)
transient cerebral ischemia  (ISO)
tuberous sclerosis 1  (ISO)
Uterine Cervical Neoplasms  (ISO)
Vascular Malformations  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-dexrazoxane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-acetamidofluorene  (EXP)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
aconitine  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (EXP)
ammonium chloride  (ISO)
arecoline  (EXP)
aristolochic acid A  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (EXP,ISO)
azoxystrobin  (ISO)
baicalein  (ISO)
baicalin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
beta-naphthoflavone  (EXP)
BI-2536  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Botulinum toxin type A  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calciol  (EXP,ISO)
captan  (EXP)
carbon nanotube  (EXP)
chloroquine  (ISO)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (EXP)
chrysene  (EXP)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
clobetasol  (EXP)
cobalt dichloride  (ISO)
cordycepin  (ISO)
crocidolite asbestos  (EXP)
Cuprizon  (ISO)
curcumin  (ISO)
Cyclopamine  (ISO)
cyclophosphamide  (ISO)
DAPT  (EXP,ISO)
DDT  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
doxorubicin  (EXP,ISO)
emodin  (ISO)
enzalutamide  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
eugenol  (EXP,ISO)
fenamidone  (EXP)
fenofibrate  (EXP)
fluoxetine  (ISO)
folic acid  (ISO)
folpet  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (ISO)
galactose  (EXP)
gemcitabine  (ISO)
gentamycin  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
isoflavones  (ISO)
isoprenaline  (ISO)
kaempferol 3-O-beta-D-glucoside  (EXP)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
LY294002  (EXP,ISO)
mebendazole  (ISO)
methoxyacetic acid  (EXP)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP,ISO)
miconazole  (EXP)
Mitotane  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
monosodium L-glutamate  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nickel dichloride  (ISO)
niclosamide  (ISO)
nicotinic acid  (ISO)
nocodazole  (ISO)
ochratoxin A  (ISO)
omacetaxine mepesuccinate  (ISO)
oxaliplatin  (ISO)
oxidopamine  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
Paeonol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentachlorophenol  (EXP)
phenethyl isothiocyanate  (ISO)
picropodophyllotoxin  (ISO)
pifithrin-?  (ISO)
pirinixic acid  (EXP)
pluronic P-123  (ISO)
Poloxamer  (ISO)
poly(ethylene)  (ISO)
potassium chromate  (ISO)
progesterone  (EXP)
propiconazole  (EXP)
propranolol  (ISO)
prostaglandin F2alpha  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
retinyl acetate  (EXP)
rotenone  (ISO)
Salidroside  (EXP)
SB 203580  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
tetraphene  (EXP)
thioacetamide  (ISO)
thiram  (ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
trans-caffeic acid  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (EXP)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
tungsten  (EXP)
tunicamycin  (EXP)
tyrphostin AG 1478  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
wortmannin  (EXP)
zalcitabine  (EXP)
zearalenone  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA)
animal organ regeneration  (ISO)
aortic valve morphogenesis  (IGI,IMP,ISO)
apoptotic process  (IDA)
apoptotic process involved in embryonic digit morphogenesis  (IMP)
arterial endothelial cell differentiation  (IMP)
astrocyte differentiation  (ISO)
atrioventricular node development  (IMP)
atrioventricular valve morphogenesis  (IMP)
auditory receptor cell fate commitment  (IMP)
axon guidance  (IBA)
axonogenesis  (IDA,IMP)
branching morphogenesis of an epithelial tube  (IMP)
calcium-ion regulated exocytosis  (IMP)
cardiac atrium morphogenesis  (IMP)
cardiac chamber formation  (IMP)
cardiac epithelial to mesenchymal transition  (IMP)
cardiac left ventricle morphogenesis  (IMP)
cardiac muscle cell myoblast differentiation  (IMP)
cardiac muscle cell proliferation  (IMP)
cardiac muscle tissue morphogenesis  (IMP)
cardiac right atrium morphogenesis  (IMP)
cardiac right ventricle formation  (IMP)
cardiac septum morphogenesis  (IMP)
cardiac vascular smooth muscle cell development  (IMP)
cardiac ventricle morphogenesis  (IMP)
cell differentiation  (IMP)
cell differentiation in spinal cord  (ISO)
cell migration involved in endocardial cushion formation  (IMP)
cell population proliferation  (IGI)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to hypoxia  (IDA)
cellular response to tumor cell  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
chemical synaptic transmission, postsynaptic  (IDA,IMP)
collecting duct development  (IEP)
compartment pattern specification  (IMP)
coronary artery morphogenesis  (IMP)
coronary sinus valve morphogenesis  (IMP)
coronary vein morphogenesis  (IMP)
determination of left/right symmetry  (IMP)
distal tubule development  (IEP)
embryonic hindlimb morphogenesis  (IMP)
embryonic limb morphogenesis  (IGI)
endocardial cell differentiation  (IMP)
endocardial cushion development  (IMP)
endocardial cushion morphogenesis  (IGI,IMP)
endocardium development  (IMP)
endocardium morphogenesis  (IEP,IMP)
endoderm development  (IMP)
epidermal cell fate specification  (IMP)
epidermis development  (IGI)
epithelial cell fate commitment  (IMP)
epithelial cell proliferation  (IGI,IMP)
epithelial to mesenchymal transition  (IMP,ISO)
epithelial to mesenchymal transition involved in endocardial cushion formation  (IMP)
forebrain development  (IGI,IMP)
foregut morphogenesis  (IMP)
gene expression  (IDA)
glial cell differentiation  (IMP)
glomerular mesangial cell development  (IEP)
growth involved in heart morphogenesis  (IMP)
hair follicle morphogenesis  (IMP)
heart development  (ISO)
heart looping  (IGI)
heart trabecula morphogenesis  (IMP)
homeostasis of number of cells within a tissue  (IGI)
humoral immune response  (IGI)
in utero embryonic development  (IMP)
inflammatory response to antigenic stimulus  (IGI)
inhibition of neuroepithelial cell differentiation  (IMP)
interleukin-17-mediated signaling pathway  (IDA)
keratinocyte differentiation  (IGI,IMP)
left/right axis specification  (IGI)
liver development  (IMP)
lung development  (IMP)
luteolysis  (ISO)
mesenchymal cell development  (IMP)
mitral valve formation  (ISO)
negative regulation of anoikis  (ISO)
negative regulation of biomineral tissue development  (IDA,IMP)
negative regulation of BMP signaling pathway  (IMP)
negative regulation of calcium ion-dependent exocytosis  (IMP)
negative regulation of canonical Wnt signaling pathway  (IMP)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cardiac muscle hypertrophy  (IMP)
negative regulation of catalytic activity  (IDA)
negative regulation of cell adhesion molecule production  (ISO)
negative regulation of cell migration involved in sprouting angiogenesis  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell proliferation involved in heart valve morphogenesis  (IDA,IMP)
negative regulation of cell-cell adhesion mediated by cadherin  (ISO)
negative regulation of cell-substrate adhesion  (ISO)
negative regulation of cold-induced thermogenesis  (IMP)
negative regulation of collagen biosynthetic process  (ISO)
negative regulation of DNA-templated transcription  (IDA,IMP)
negative regulation of endothelial cell chemotaxis  (ISO)
negative regulation of epithelial cell proliferation  (IMP)
negative regulation of extracellular matrix constituent secretion  (IMP)
negative regulation of gene expression  (ISO)
negative regulation of glial cell proliferation  (IDA)
negative regulation of inner ear auditory receptor cell differentiation  (IMP)
negative regulation of myoblast differentiation  (ISO)
negative regulation of myotube differentiation  (IMP)
negative regulation of neurogenesis  (IMP)
negative regulation of neuron differentiation  (IGI,IMP,ISO)
negative regulation of oligodendrocyte differentiation  (IDA)
negative regulation of ossification  (IMP)
negative regulation of osteoblast differentiation  (IMP)
negative regulation of photoreceptor cell differentiation  (IMP)
negative regulation of pro-B cell differentiation  (IMP)
negative regulation of programmed cell death  (IMP)
negative regulation of stem cell differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (IDA,IMP,ISO)
neural tube development  (IMP)
neuroendocrine cell differentiation  (IMP)
neuron differentiation  (IGI,IMP)
neuron fate commitment  (IGI)
neuronal stem cell population maintenance  (ISO)
Notch signaling pathway  (IBA,IC,IDA,IGI,IMP,ISO)
Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation  (IMP)
oligodendrocyte differentiation  (IMP,ISO)
osteoblast fate commitment  (NAS)
outflow tract morphogenesis  (ISO)
pericardium morphogenesis  (IMP)
positive regulation of aorta morphogenesis  (IMP)
positive regulation of apoptotic process  (IDA,IGI)
positive regulation of apoptotic process involved in morphogenesis  (IDA)
positive regulation of astrocyte differentiation  (IDA)
positive regulation of BMP signaling pathway  (IDA)
positive regulation of cardiac epithelial to mesenchymal transition  (ISO)
positive regulation of cardiac muscle cell proliferation  (IMP)
positive regulation of cell migration  (IMP)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (IDA)
positive regulation of endothelial cell differentiation  (ISO)
positive regulation of ephrin receptor signaling pathway  (IC)
positive regulation of epithelial cell proliferation  (IGI)
positive regulation of epithelial to mesenchymal transition  (IMP)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (IGI,ISO)
positive regulation of glial cell differentiation  (ISO)
positive regulation of keratinocyte differentiation  (IDA,IGI)
positive regulation of neuroblast proliferation  (ISO)
positive regulation of Notch signaling pathway  (IDA)
positive regulation of Ras protein signal transduction  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (IDA)
positive regulation of smooth muscle cell differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,IMP,ISO)
positive regulation of transcription of Notch receptor target  (IGI,ISO)
positive regulation of viral genome replication  (IMP)
positive regulation of viral transcription  (IMP)
prostate gland epithelium morphogenesis  (IMP)
protein catabolic process  (IDA)
protein import into nucleus  (IDA)
pulmonary valve morphogenesis  (IGI,IMP,ISO)
regulation of cardioblast proliferation  (ISO)
regulation of cell adhesion involved in heart morphogenesis  (IMP)
regulation of cell migration  (IMP)
regulation of cell population proliferation  (ISO)
regulation of developmental process  (IEA)
regulation of DNA-templated transcription  (IEA)
regulation of epithelial cell proliferation  (IGI,IMP)
regulation of epithelial cell proliferation involved in prostate gland development  (IMP)
regulation of extracellular matrix assembly  (IMP)
regulation of gene expression  (IMP)
regulation of inner ear auditory receptor cell differentiation  (IMP)
regulation of neurogenesis  (IMP)
regulation of Notch signaling pathway  (IGI)
regulation of postsynaptic neurotransmitter receptor activity  (IDA,IMP)
regulation of somitogenesis  (IMP)
regulation of stem cell proliferation  (IMP)
regulation of transcription by RNA polymerase II  (IGI,IMP)
response to lipopolysaccharide  (ISO)
response to muramyl dipeptide  (IDA)
retinal cone cell differentiation  (IMP)
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development  (IMP)
skeletal muscle cell differentiation  (IMP)
somatic stem cell division  (IDA,IGI)
spermatogenesis  (ISO)
sprouting angiogenesis  (IMP)
T-helper 17 type immune response  (IDA)
tissue regeneration  (ISO)
transcription by RNA polymerase II  (IDA,IGI)
tube formation  (ISO)
vasculogenesis involved in coronary vascular morphogenesis  (IMP)
venous blood vessel morphogenesis  (IMP)
venous endothelial cell differentiation  (IMP)
ventricular septum morphogenesis  (IGI,IMP,ISO)
ventricular trabecula myocardium morphogenesis  (IMP)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal angiogenesis  (IAGP)
abnormal anterior cardinal vein morphology  (IAGP)
abnormal aortic valve morphology  (IAGP)
abnormal apoptosis  (IAGP)
abnormal artery morphology  (IAGP)
abnormal atrioventricular cushion morphology  (IAGP)
abnormal B cell differentiation  (IAGP)
abnormal B cell morphology  (IAGP)
abnormal branching involved in pancreas development  (IAGP)
abnormal cardiac epithelial to mesenchymal transition  (IAGP)
abnormal cell death  (IAGP)
abnormal cochlear inner hair cell morphology  (IAGP)
abnormal cornea morphology  (IAGP)
abnormal coronary vessel morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal dendritic cell differentiation  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal direction of heart looping  (IAGP)
abnormal dorsal aorta morphology  (IAGP)
abnormal embryo development  (IAGP)
abnormal embryonic neuroepithelium morphology  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal endocrine pancreas morphology  (IAGP)
abnormal hair follicle melanocyte morphology  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal hair growth  (IAGP)
abnormal hair shaft morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal hepatic cord morphology  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal intersomitic vessel morphology  (IAGP)
abnormal left-right axis patterning  (IAGP)
abnormal left-right axis symmetry of the somites  (IAGP)
abnormal liver lobule morphology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal liver parenchyma morphology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal nervous system development  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal pancreas development  (IAGP)
abnormal pancreatic acinus morphology  (IAGP)
abnormal pancreatic bud formation  (IAGP)
abnormal pericyte morphology  (IAGP)
abnormal placenta vasculature  (IAGP)
abnormal placental labyrinth vasculature morphology  (IAGP)
abnormal postnatal subventricular zone morphology  (IAGP)
abnormal response to infection  (IAGP)
abnormal retina blood vessel morphology  (IAGP)
abnormal retina vasculature morphology  (IAGP)
abnormal rostral migratory stream morphology  (IAGP)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal somite development  (IAGP)
abnormal somite size  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell receptor beta chain V(D)J recombination  (IAGP)
abnormal thymus cell ratio  (IAGP)
abnormal thymus morphology  (IAGP)
abnormal trigeminal ganglion morphology  (IAGP)
abnormal vascular branching morphogenesis  (IAGP)
abnormal vascular development  (IAGP)
abnormal vascular plexus formation  (IAGP)
abnormal vascular smooth muscle morphology  (IAGP)
abnormal vasculogenesis  (IAGP)
abnormal vein morphology  (IAGP)
abnormal venule morphology  (IAGP)
abnormal vertebrae morphology  (IAGP)
abnormal vitelline vascular remodeling  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent coronary vessels  (IAGP)
absent hair follicle inner root sheath  (IAGP)
absent sebaceous gland  (IAGP)
absent vitelline blood vessels  (IAGP)
alopecia  (IAGP)
anemia  (IAGP)
aortic valve inflammation  (IAGP)
arrested T cell differentiation  (IAGP)
arteriovenous malformation  (IAGP)
bicuspid aortic valve  (IAGP)
calcified aortic valve cusp  (IAGP)
chronic liver inflammation  (IAGP)
cornea deposits  (IAGP)
cornea vascularization  (IAGP)
decreased angiogenesis  (IAGP)
decreased body weight  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased conjunctiva goblet cell number  (IAGP)
decreased double-negative T cell number  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased embryo size  (IAGP)
decreased interleukin-4 secretion  (IAGP)
decreased organ of Corti supporting cell number  (IAGP)
decreased pancreatic islet number  (IAGP)
decreased single-positive T cell number  (IAGP)
decreased T cell number  (IAGP)
decreased thymocyte number  (IAGP)
delayed heart looping  (IAGP)
delayed somite formation  (IAGP)
dilated liver sinusoidal space  (IAGP)
diluted coat color  (IAGP)
disorganized inner root sheath cells  (IAGP)
disorganized myocardium  (IAGP)
distended pericardium  (IAGP)
dry eyes  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality  (IAGP)
embryonic lethality during organogenesis  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged spleen  (IAGP)
epidermal hyperplasia  (IAGP)
extramedullary hematopoiesis  (IAGP)
hair follicle degeneration  (IAGP)
hemopericardium  (IAGP)
hemoperitoneum  (IAGP)
hemorrhage  (IAGP)
impaired basement membrane formation  (IAGP)
incomplete embryo turning  (IAGP)
incomplete somite formation  (IAGP)
increased angiogenesis  (IAGP)
increased apoptosis  (IAGP)
increased cochlear inner hair cell number  (IAGP)
increased cochlear outer hair cell number  (IAGP)
increased grip strength  (IEA)
increased hemangioma incidence  (IAGP)
increased hematopoietic cell number  (IAGP)
increased immature B cell number  (IAGP)
increased leukemia incidence  (IAGP)
increased neuron number  (IAGP)
increased single-positive T cell number  (IAGP)
increased spleen red pulp amount  (IAGP)
increased startle reflex  (IEA)
increased T cell apoptosis  (IAGP)
increased vascular permeability  (IAGP)
internal hemorrhage  (IAGP)
kinked neural tube  (IAGP)
lacrimal gland degeneration  (IAGP)
Meibomian gland degeneration  (IAGP)
myocardium hypoplasia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neural tube degeneration  (IAGP)
no abnormal phenotype detected  (IAGP)
notochord degeneration  (IAGP)
open neural tube  (IAGP)
pale liver  (IAGP)
pale yolk sac  (IAGP)
pericardial edema  (IAGP)
pericardial effusion  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IEA)
progressive hair loss  (IAGP)
renal hypoplasia  (IAGP)
scaly skin  (IAGP)
short hair  (IAGP)
small pancreas  (IAGP)
small pharyngeal arch  (IAGP)
small sebaceous gland  (IAGP)
small thymus  (IAGP)
thick aortic valve cusps  (IAGP)
thick epidermis  (IAGP)
thin myocardium  (IAGP)
thin myocardium compact layer  (IAGP)
thymus hypoplasia  (IAGP)
trabecula carnea hypoplasia  (IAGP)
waved hair  (IAGP)
References

References - curated
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19. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
20. MGDs mouse GO annotations MGD data from the GO Consortium
21. MGD IEA MGD IEA
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23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
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25. Activation of multiple angiogenic signaling pathways in hemangiopericytoma. Pierscianek D, etal., Brain Tumor Pathol. 2016 Jul;33(3):200-8. doi: 10.1007/s10014-016-0256-6. Epub 2016 Mar 7.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
28. Si-Miao-Yong-An on promoting the maturation of Vasa Vasorum and stabilizing atherosclerotic plaque in ApoE-/- mice： An experimental study. Qi Z, etal., Biomed Pharmacother. 2019 Jun;114:108785. doi: 10.1016/j.biopha.2019.108785. Epub 2019 Mar 23.
29. Mouse MP Annotation Import Pipeline RGD automated import pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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33. Gamma-Secretase Inhibitor, DAPT, Prevents the Development of Retinopathy of Prematurity in a Rat Model by Regulating the Delta-Like Ligand 4/Notch Homolog-1 (DLL4/Notch-1) Pathway. Sun W, etal., Med Sci Monit. 2019 Jan 17;25:492-499. doi: 10.12659/MSM.913828.
34. Imbalanced expression of TAN-1 and human Notch4 in endometrial cancers. Suzuki T, etal., Int J Oncol. 2000 Dec;17(6):1131-9.
35. Notch 1 and 3 receptor signaling modulates vascular smooth muscle cell growth, apoptosis, and migration via a CBF-1/RBP-Jk dependent pathway. Sweeney C, etal., FASEB J. 2004 Sep;18(12):1421-3. Epub 2004 Jul 9.
36. The role of HIF-1, angiopoietin-2, Dll4 and Notch1 in bleeding gastrointestinal vascular malformations and thalidomide-associated actions: a pilot in vivo study. Tan HH, etal., J Dig Dis. 2011 Oct;12(5):349-56. doi: 10.1111/j.1751-2980.2011.00506.x.
37. Down-regulation of the microRNAs miR-34a, miR-127, and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet. Tryndyak VP, etal., Mol Carcinog. 2009 Jun;48(6):479-87.
38. Reduced Notch1 Cleavage Promotes the Development of Pulmonary Hypertension. Wang S, etal., Hypertension. 2022 Jan;79(1):79-92. doi: 10.1161/HYPERTENSIONAHA.120.16065. Epub 2021 Nov 5.
39. Notch pathway is activated in cell culture and mouse models of mutant SOD1-related familial amyotrophic lateral sclerosis, with suppression of its activation as an additional mechanism of neuroprotection for lithium and valproate. Wang SY, etal., Neuroscience. 2015 Aug 20;301:276-88. doi: 10.1016/j.neuroscience.2015.06.002. Epub 2015 Jun 8.
40. Coordinate Notch3-hairy-related transcription factor pathway regulation in response to arterial injury. Mediator role of platelet-derived growth factor and ERK. Wang W, etal., J Biol Chem 2002 Jun 28;277(26):23165-71.
41. A homolog of Drosophila Notch expressed during mammalian development. Weinmaster G, etal., Development 1991 Sep;113(1):199-205.
42. The expression levels of Notch-related signaling molecules in pulmonary microvascular endothelial cells in bleomycin-induced rat pulmonary fibrosis. Yin Q, etal., Physiol Res. 2017 May 4;66(2):305-315. doi: 10.33549/physiolres.933356. Epub 2016 Dec 16.
43. Activation of the Notch signaling pathway disturbs the CD4+/CD8+, Th17/Treg balance in rats with experimental autoimmune uveitis. Yin X, etal., Inflamm Res. 2019 Sep;68(9):761-774. doi: 10.1007/s00011-019-01260-w. Epub 2019 Jun 17.
44. Olmesartan attenuates cardiac remodeling through DLL4/Notch1 pathway activation in pressure overload mice. You J, etal., J Cardiovasc Pharmacol. 2013 Feb;61(2):142-51. doi: 10.1097/FJC.0b013e31827a0278.
45. Triggering of a Dll4-Notch1 loop impairs wound healing in diabetes. Zheng X, etal., Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6985-6994. doi: 10.1073/pnas.1900351116. Epub 2019 Mar 18.
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Additional References at PubMed
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