Nos1 (nitric oxide synthase 1, neuronal) - Rat Genome Database

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Gene: Nos1 (nitric oxide synthase 1, neuronal) Mus musculus
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Symbol: Nos1
Name: nitric oxide synthase 1, neuronal
RGD ID: 10991
MGI Page MGI
Description: Enables nitric-oxide synthase activity. Involved in several processes, including nitric oxide biosynthetic process; positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process; and positive regulation of nitrogen compound metabolic process. Acts upstream of or within several processes, including peptidyl-cysteine S-nitrosylation; positive regulation of transcription by RNA polymerase II; and regulation of metal ion transport. Located in several cellular components, including T-tubule; Z disc; and sarcoplasmic reticulum membrane. Is active in calyx of Held. Colocalizes with caveola. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study achalasia and hypertrophic pyloric stenosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; asthma; cystic fibrosis; and hypertrophic pyloric stenosis. Orthologous to human NOS1 (nitric oxide synthase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2310005C01Rik; b; bNOS; constitutive NOS; N-NOS; NC-NOS; neuronal nitric oxide synthase; neuronal NOS; nitric oxide synthase, brain; nNOS; NO; NOS; NOS type I; Nos-1; NOS-I; peptidyl-cysteine S-nitrosylase NOS1; RIKEN cDNA 2310005C01 gene
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395118,004,904 - 118,096,905 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5117,919,097 - 118,096,905 (+)EnsemblGRCm39 Ensembl
GRCm385117,866,839 - 117,958,840 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5117,781,032 - 117,958,840 (+)EnsemblGRCm38mm10GRCm38
MGSCv375118,317,128 - 118,403,822 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365118,128,149 - 118,214,843 (+)NCBIMGSCv36mm8
Celera5114,958,747 - 115,046,830 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map557.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
achalasia  (IAGP)
acute kidney failure  (ISO)
acute necrotizing pancreatitis  (ISO)
alcoholic cardiomyopathy  (ISO)
Alzheimer's disease  (ISO)
amphetamine abuse  (ISO)
arteriosclerosis  (IAGP)
asthma  (ISO)
autism spectrum disorder  (ISO)
brain ischemia  (ISO)
Bronchial Hyperreactivity  (IEP)
Carbon Monoxide Poisoning  (IMP)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
cerebellar disease  (ISO)
chronic obstructive pulmonary disease  (ISO)
congestive heart failure  (ISO)
cystic fibrosis  (ISO)
Dehydration  (ISO)
depressive disorder  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
disease of mental health  (ISO)
Duchenne muscular dystrophy  (ISO)
End Stage Liver Disease  (ISO)
end stage renal disease  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Radiation Injuries  (ISO)
fetal alcohol spectrum disorder  (ISO)
Fetal Growth Retardation  (ISO)
Fetal Hypoxia  (ISO)
Fever  (ISO)
genetic disease  (ISO)
Heat Stroke  (ISO)
hepatic encephalopathy  (ISO)
Human Influenza  (IEP)
Hyperalgesia  (ISO)
hypertension  (ISO)
hypertrophic pyloric stenosis  (IAGP)
Hypoxia  (ISO)
impotence  (ISO)
Infantile Hypertrophic Pyloric Stenosis 1  (ISO)
intestinal perforation  (ISO)
intracranial aneurysm  (IMP)
major depressive disorder  (ISO)
Memory Disorders  (ISO)
morphine dependence  (ISO)
motor neuron disease  (ISO)
nephrotic syndrome  (ISO)
Nerve Degeneration  (ISO)
nervous system disease  (ISO)
Nervous System Trauma  (ISO)
Neuralgia  (ISO)
Neurobehavioral Manifestations  (ISO)
obesity  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
portal hypertension  (ISO)
Prehypertension  (ISO)
renovascular hypertension  (ISO)
Reperfusion Injury  (ISO)
retinopathy of prematurity  (ISO)
Right Ventricular Hypertrophy  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
Spinal Cord Injuries  (ISO)
status epilepticus  (ISO)
Stroke  (ISO)
temporal lobe epilepsy  (ISO)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urethral obstruction  (ISO)
Urination Disorders  (ISO)
Ventricular Remodeling  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(3,4-dihydroxyphenyl)acetic acid  (EXP)
(S)-amphetamine  (EXP)
(S)-colchicine  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,6-trinitrotoluene  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-BROMO-7-NITROINDAZOLE  (EXP)
4-hydroxy-TEMPO  (ISO)
5,5-dimethyl-1-pyrroline N-oxide  (ISO)
6-propyl-2-thiouracil  (ISO)
7,8-Diacetoxy-4-methylcoumarin  (ISO)
7-NITROINDAZOLE  (EXP,ISO)
8'-apo-beta,psi-caroten-8'-al  (ISO)
acetamide  (ISO)
acrylamide  (EXP,ISO)
ADP-D-ribose  (EXP)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
alloxan  (EXP)
aluminium sulfate (anhydrous)  (ISO)
aminoguanidine  (ISO)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-carotene  (ISO)
betulinic acid  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (EXP,ISO)
Brodifacoum  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcium atom  (ISO)
calcium dichloride  (ISO)
calcium(0)  (ISO)
Candesartan cilexetil  (ISO)
cantharidin  (ISO)
capsaicin  (ISO)
CGP 52608  (ISO)
chaetocin  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
curcumin  (EXP,ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
Decursin  (EXP)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (ISO)
dibutylstannane  (ISO)
dichlorine  (ISO)
dichloroacetic acid  (EXP)
dimemorfan  (ISO)
diminazene diaceturate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dizocilpine maleate  (EXP)
dobutamine  (EXP)
dopamine  (EXP)
dorsomorphin  (ISO)
edaravone  (ISO)
endosulfan  (ISO)
enoxacin  (EXP)
entinostat  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
fenbufen  (EXP)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glucose  (ISO)
GW 4064  (EXP)
hexachlorobenzene  (ISO)
hexacosan-1-ol  (ISO)
homovanillic acid  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
icariin  (ISO)
ifosfamide  (ISO)
indometacin  (EXP)
isoprenaline  (ISO)
kainic acid  (ISO)
KT 5720  (ISO)
lead diacetate  (EXP,ISO)
lead(II) chloride  (ISO)
leflunomide  (ISO)
linsidomine  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium chloride  (ISO)
lithium hydride  (ISO)
losartan  (ISO)
lycopene  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP)
manganese(II) sulfate  (ISO)
mastoparan  (ISO)
Mazindol  (EXP)
melatonin  (ISO)
melittin  (ISO)
mephedrone  (ISO)
mercury dichloride  (ISO)
metformin  (EXP)
methamphetamine  (EXP)
methoctramine tetrahydrochloride  (ISO)
metoprolol  (ISO)
mevinphos  (ISO)
milrinone  (EXP)
morin  (ISO)
morphine  (EXP,ISO)
N,N-diethyl-m-toluamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-D-aspartic acid  (EXP)
naloxone  (EXP)
Neferine  (ISO)
nickel atom  (ISO)
nitric oxide  (EXP,ISO)
nitroglycerin  (ISO)
nitroprusside  (ISO)
O-acetyl-L-carnitine  (ISO)
ouabain  (ISO)
oxidopamine  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
palytoxin  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (ISO)
phenol  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
progesterone  (EXP,ISO)
propanal  (ISO)
puerarin  (EXP)
quercetin  (EXP,ISO)
ramipril  (ISO)
reactive nitrogen species  (ISO)
reactive oxygen species  (ISO)
reserpine  (ISO)
resveratrol  (EXP,ISO)
rofecoxib  (ISO)
S-methyl-L-thiocitrulline  (EXP,ISO)
SB 431542  (ISO)
selenic acid  (ISO)
selenomethionine  (ISO)
serpentine asbestos  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirtinol  (ISO)
sodium arsenite  (ISO)
sodium atom  (ISO)
sodium chloride  (ISO)
sodium sulfite  (ISO)
streptozocin  (EXP,ISO)
sumatriptan  (ISO)
tacrine  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
thymoquinone  (ISO)
tributylstannane  (ISO)
triclosan  (EXP)
triphenylstannane  (ISO)
triptonide  (EXP)
Tropicamide  (ISO)
trovafloxacin  (EXP)
U-73122  (ISO)
udenafil  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vincristine  (EXP)
zileuton  (EXP)
zinc protoporphyrin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
arginine catabolic process  (IBA,ISO)
behavioral response to cocaine  (ISO)
calcium ion transport  (IMP)
cellular response to epinephrine stimulus  (ISO)
cellular response to growth factor stimulus  (IMP)
cellular response to mechanical stimulus  (ISO)
establishment of localization in cell  (IMP)
establishment of protein localization  (ISO)
female pregnancy  (ISO)
multicellular organismal response to stress  (ISO)
muscle contraction  (IBA)
negative regulation of apoptotic process  (ISO)
negative regulation of blood pressure  (IBA,ISO)
negative regulation of calcium ion transport  (IMP)
negative regulation of cell population proliferation  (ISO)
negative regulation of cytosolic calcium ion concentration  (ISO)
negative regulation of hepatic stellate cell contraction  (ISO)
negative regulation of hydrolase activity  (IMP)
negative regulation of insulin secretion  (ISO)
negative regulation of iron ion transmembrane transport  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of peptidyl-serine phosphorylation  (ISO)
negative regulation of potassium ion transport  (IMP)
negative regulation of serotonin uptake  (IDA)
negative regulation of vasoconstriction  (ISO)
nitric oxide biosynthetic process  (IBA,IDA,ISO)
nitric oxide mediated signal transduction  (IBA,ISO)
peptidyl-cysteine S-nitrosylation  (IDA,ISO)
positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process  (IMP)
positive regulation of cellular process  (ISO)
positive regulation of DNA-templated transcription  (IMP)
positive regulation of guanylate cyclase activity  (IBA)
positive regulation of histone acetylation  (IMP)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of sodium ion transmembrane transport  (ISO)
positive regulation of the force of heart contraction  (IMP)
positive regulation of transcription by RNA polymerase II  (IMP)
potassium ion transport  (IMP)
regulation of neurogenesis  (IDA)
regulation of postsynaptic membrane potential  (IDA,IMP)
regulation of sodium ion transport  (IMP)
response to activity  (ISO)
response to estrogen  (ISO)
response to ethanol  (ISO)
response to heat  (ISO)
response to hormone  (IBA)
response to hypoxia  (ISO)
response to lead ion  (ISO)
response to lipopolysaccharide  (IBA,ISO)
response to nicotine  (ISO)
response to nitric oxide  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to organonitrogen compound  (ISO)
response to peptide hormone  (ISO)
response to vitamin E  (ISO)
retrograde trans-synaptic signaling by nitric oxide  (IBA,IMP)
striated muscle contraction  (IMP)
synaptic signaling by nitric oxide  (IDA,IMP)
vasodilation  (ISO)
xenobiotic catabolic process  (IMP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal angiogenesis  (IAGP)
abnormal behavioral response to addictive substance  (IAGP)
abnormal blood-brain barrier function  (IAGP)
abnormal bone mineralization  (IAGP)
abnormal bone structure  (IAGP)
abnormal brain morphology  (IAGP)
abnormal brain wave pattern  (IAGP)
abnormal breathing pattern  (IAGP)
abnormal carbon dioxide production  (IAGP)
abnormal cardiac muscle relaxation  (IAGP)
abnormal cardiovascular system morphology  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal cerebral blood flow rate  (IAGP)
abnormal circulating glucose level  (IAGP)
abnormal circulating pyruvate kinase level  (IAGP)
abnormal coronary artery morphology  (IAGP)
abnormal dendrite morphology  (IAGP)
abnormal digestion  (IAGP)
abnormal gastroesophageal sphincter physiology  (IAGP)
abnormal glomerular capillary thrombosis  (IAGP)
abnormal heart rate  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal hypothalamus secretion  (IAGP)
abnormal kidney physiology  (IAGP)
abnormal leukocyte adhesion  (IAGP)
abnormal liquid preference  (IAGP)
abnormal liver morphology  (IAGP)
abnormal long term potentiation  (IAGP)
abnormal maternal behavior  (IAGP)
abnormal mating frequency  (IAGP)
abnormal mitochondrial physiology  (IAGP)
abnormal motor neuron morphology  (IAGP)
abnormal muscle physiology  (IAGP)
abnormal muscle relaxation  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neutrophil physiology  (IAGP)
abnormal nitric oxide homeostasis  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal osteoclast physiology  (IAGP)
abnormal oxygen consumption  (IAGP)
abnormal peripheral nervous system regeneration  (IAGP)
abnormal physiological response to xenobiotic  (IAGP)
abnormal pulmonary respiratory rate response  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal renal reabsorption  (IAGP)
abnormal renal tubule morphology  (IAGP)
abnormal renal water reabsorption  (IAGP)
abnormal response of heart to induced stress  (IAGP)
abnormal seizure response to inducing agent  (IAGP)
abnormal sensory neuron innervation pattern  (IAGP)
abnormal serotonin level  (IAGP)
abnormal skeleton development  (IAGP)
abnormal skeleton physiology  (IAGP)
abnormal sleep pattern  (IAGP)
abnormal spatial learning  (IAGP)
abnormal stomach wall morphology  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal vascular endothelial cell physiology  (IAGP)
abnormal vascular wound healing  (IAGP)
absent long term depression  (IAGP)
arteriosclerosis  (IAGP)
cardiac interstitial fibrosis  (IAGP)
congestive heart failure  (IAGP)
decreased adiponectin level  (IAGP)
decreased aggression towards male mice  (IAGP)
decreased body weight  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased cerebral infarct size  (IAGP)
decreased circulating follicle stimulating hormone level  (IAGP)
decreased circulating thyroxine level  (IAGP)
decreased coronary flow rate  (IAGP)
decreased corpora lutea number  (IAGP)
decreased heart rate  (IAGP)
decreased heart weight  (IAGP)
decreased inflammatory response  (IAGP)
decreased left ventricle diastolic pressure  (IAGP)
decreased locomotor activity  (IAGP)
decreased mean systemic arterial blood pressure  (IAGP)
decreased ovary weight  (IAGP)
decreased ovulation rate  (IAGP)
decreased oxygen consumption  (IAGP)
decreased sensitivity to induced morbidity/mortality  (IAGP)
decreased skeletal muscle weight  (IAGP)
decreased superovulation rate  (IAGP)
decreased survivor rate  (IAGP)
decreased susceptibility to induced choroidal neovascularization  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased susceptibility to ischemic brain injury  (IAGP)
decreased susceptibility to neuronal excitotoxicity  (IAGP)
decreased synaptic glutamate release  (IAGP)
decreased testis weight  (IAGP)
decreased urine osmolality  (IAGP)
decreased urine sodium level  (IAGP)
dehydration  (IAGP)
delayed estrous cycle  (IAGP)
delayed peripheral nervous system regeneration  (IAGP)
dystrophic muscle  (IAGP)
enhanced behavioral response to addictive substance  (IAGP)
enhanced coordination  (IAGP)
enhanced leukocyte tethering or rolling  (IAGP)
enlarged duodenum  (IAGP)
enlarged esophagus  (IAGP)
enlarged stomach  (IAGP)
gastric hypertrophy  (IAGP)
glomerulosclerosis  (IAGP)
heart left ventricle hypertrophy  (IAGP)
hypertension  (IAGP)
impaired balance  (IAGP)
impaired gastric peristalsis  (IAGP)
impaired skeletal muscle contractility  (IAGP)
increased aggression towards female mice  (IAGP)
increased aggression towards male mice  (IAGP)
increased alcohol consumption  (IAGP)
increased anxiety-related response  (IAGP)
increased blood osmolality  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased body weight  (IAGP)
increased bone mineral content  (IAGP)
increased bone mineral density  (IAGP)
increased cardiac muscle contractility  (IAGP)
increased circulating alkaline phosphatase level  (IAGP)
increased circulating corticosterone level  (IAGP)
increased circulating creatinine level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating LDL cholesterol level  (IAGP)
increased circulating leptin level  (IAGP)
increased circulating luteinizing hormone level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased coping response  (IAGP)
increased food intake  (IAGP)
increased grooming behavior  (IAGP)
increased heart rate  (IAGP)
increased muscle fatigability  (IAGP)
increased osteoclast cell number  (IAGP)
increased oxygen consumption  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased prostaglandin level  (IAGP)
increased pulmonary respiratory rate  (IAGP)
increased pulmonary ventilation  (IAGP)
increased renal tubule apoptosis  (IAGP)
increased systemic arterial blood pressure  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased tidal volume  (IAGP)
increased total body fat amount  (IAGP)
increased trabecular bone thickness  (IAGP)
increased trabecular bone volume  (IAGP)
increased urine bicarbonate level  (IAGP)
increased urine pH  (IAGP)
increased ventricle muscle contractility  (IAGP)
increased white adipose tissue amount  (IAGP)
insulin resistance  (IAGP)
liver vascular congestion  (IAGP)
male infertility  (IAGP)
maternal effect  (IAGP)
metabolic acidosis  (IAGP)
no abnormal phenotype detected  (IEA)
perivascular fibrosis  (IAGP)
polydipsia  (IAGP)
polyuria  (IAGP)
premature death  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
pulmonary vascular congestion  (IAGP)
pyloric sphincter hypertrophy  (IAGP)
pyloric stenosis  (IAGP)
reduced female fertility  (IAGP)
reduced fertility  (IAGP)
reduced long term potentiation  (IAGP)
renal tubular necrosis  (IAGP)
slow Wallerian degeneration  (IAGP)
stomach smooth muscle circular layer hypertrophy  (IAGP)
thick ventricular wall  (IAGP)
visceral vascular congestion  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Altered Contractile Response due to Increased beta3-Adrenoceptor Stimulation in Diabetic Cardiomyopathy: The Role of Nitric Oxide Synthase 1-derived Nitric Oxide. Amour J, etal., Anesthesiology. 2007 Sep;107(3):452-460.
2. Complementary inhibition of cerebral aneurysm formation by eNOS and nNOS. Aoki T, etal., Lab Invest. 2011 Apr;91(4):619-26. Epub 2011 Feb 14.
3. Renoprotective effect of pioglitazone by the prevention of glomerular hyperfiltration through the possible restoration of altered macula densa signaling in rats with type 2 diabetic nephropathy. Asakura J, etal., Nephron Exp Nephrol. 2012;122(3-4):83-94. doi: 10.1159/000348661. Epub 2013 Mar 29.
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PMID:19679819   PMID:19706695   PMID:19718040   PMID:19730405   PMID:19734360   PMID:19766235   PMID:19770398   PMID:19775503   PMID:19800018   PMID:19800948   PMID:19845829   PMID:19855026  
PMID:19926812   PMID:19931630   PMID:19934009   PMID:19936028   PMID:19940861   PMID:19959818   PMID:20080794   PMID:20124730   PMID:20147620   PMID:20158465   PMID:20164327   PMID:20304785  
PMID:20392943   PMID:20435320   PMID:20436479   PMID:20438808   PMID:20483958   PMID:20507551   PMID:20530114   PMID:20543469   PMID:20561153   PMID:20581102   PMID:20624383   PMID:20638384  
PMID:20651700   PMID:20655878   PMID:20661721   PMID:20662604   PMID:20707635   PMID:20720107   PMID:20727829   PMID:20739607   PMID:20826310   PMID:20845474   PMID:20921441   PMID:20944551  
PMID:20951772   PMID:20953358   PMID:21073925   PMID:21082337   PMID:21102461   PMID:21125668   PMID:21148012   PMID:21179208   PMID:21267068   PMID:21282319   PMID:21331324   PMID:21363890  
PMID:21383158   PMID:21434910   PMID:21470341   PMID:21471366   PMID:21508214   PMID:21539806   PMID:21606640   PMID:21613472   PMID:21615722   PMID:21651902   PMID:21756313   PMID:21777607  
PMID:21780643   PMID:21791288   PMID:21813683   PMID:21825026   PMID:21849632   PMID:21858821   PMID:21873635   PMID:21884692   PMID:21890687   PMID:21896719   PMID:21935943   PMID:21943598  
PMID:21943603   PMID:21945318   PMID:21960957   PMID:21965681   PMID:21976486   PMID:21989918   PMID:22027181   PMID:22036570   PMID:22058155   PMID:22090484   PMID:22123949   PMID:22205701  
PMID:22262671   PMID:22262891   PMID:22316281   PMID:22351125   PMID:22378773   PMID:22486744   PMID:22493004   PMID:22522563   PMID:22550140   PMID:22580898   PMID:22613021   PMID:22688956  
PMID:22794259   PMID:22798524   PMID:22820053   PMID:22828515   PMID:22833130   PMID:22891311   PMID:22932783   PMID:22937058   PMID:22950758   PMID:22952904   PMID:23012472   PMID:23064802  
PMID:23091050   PMID:23100421   PMID:23142661   PMID:23202294   PMID:23277581   PMID:23312518   PMID:23359715   PMID:23362871   PMID:23434456   PMID:23478408   PMID:23504347   PMID:23507581  
PMID:23558387   PMID:23576613   PMID:23608660   PMID:23616539   PMID:23639802   PMID:23649862   PMID:23680665   PMID:23684982   PMID:23719162   PMID:23774658   PMID:23861145   PMID:23904594  
PMID:23940011   PMID:23948215   PMID:23955171   PMID:24032714   PMID:24076963   PMID:24127602   PMID:24133409   PMID:24154525   PMID:24155296   PMID:24162656   PMID:24191004   PMID:24235139  
PMID:24305053   PMID:24351932   PMID:24366262   PMID:24498331   PMID:24602444   PMID:24624894   PMID:24643800   PMID:24657074   PMID:24671193   PMID:24723342   PMID:24760996   PMID:24782615  
PMID:24812663   PMID:24813792   PMID:24899708   PMID:24911015   PMID:24952961   PMID:24981859   PMID:25017185   PMID:25025574   PMID:25071457   PMID:25125509   PMID:25129479   PMID:25151305  
PMID:25214536   PMID:25326127   PMID:25344365   PMID:25389974   PMID:25391901   PMID:25392498   PMID:25398110   PMID:25511929   PMID:25595735   PMID:25621792   PMID:25664654   PMID:25678382  
PMID:25684045   PMID:25716315   PMID:25732085   PMID:25749441   PMID:25813085   PMID:25823749   PMID:25837940   PMID:25865048   PMID:25868900   PMID:25870540   PMID:25892053   PMID:25936505  
PMID:26009878   PMID:26073142   PMID:26152695   PMID:26156989   PMID:26173391   PMID:26235957   PMID:26247728   PMID:26324446   PMID:26332085   PMID:26427435   PMID:26483274   PMID:26503494  
PMID:26604149   PMID:26617487   PMID:26647426   PMID:26648027   PMID:26671618   PMID:26727548   PMID:26791826   PMID:26861996   PMID:26883268   PMID:26976926   PMID:27006199   PMID:27032391  
PMID:27076429   PMID:27135215   PMID:27171264   PMID:27178324   PMID:27270085   PMID:27282485   PMID:27296112   PMID:27477497   PMID:27487211   PMID:27568519   PMID:27601184   PMID:27609225  
PMID:27616062   PMID:27618674   PMID:27633915   PMID:27634009   PMID:27672360   PMID:27779093   PMID:27784691   PMID:27822504   PMID:27976716   PMID:27991851   PMID:28013342   PMID:28110436  
PMID:28123012   PMID:28167615   PMID:28387937   PMID:28420791   PMID:28577305   PMID:28622359   PMID:28666850   PMID:28671186   PMID:28671696   PMID:28684471   PMID:28705804   PMID:28725180  
PMID:28731029   PMID:28800639   PMID:28942923   PMID:28951000   PMID:28973166   PMID:28974418   PMID:28985566   PMID:29031500   PMID:29043563   PMID:29066445   PMID:29093670   PMID:29110178  
PMID:29123082   PMID:29183804   PMID:29192291   PMID:29233575   PMID:29234274   PMID:29268095   PMID:29374161   PMID:29379870   PMID:29394072   PMID:29438803   PMID:29444423   PMID:29462275  
PMID:29489747   PMID:29556030   PMID:29572434   PMID:29577585   PMID:29605772   PMID:29667908   PMID:29678764   PMID:29748916   PMID:29790927   PMID:29869132   PMID:29911171   PMID:29914853  
PMID:29915136   PMID:30028847   PMID:30143658   PMID:30177704   PMID:30193808   PMID:30236982   PMID:30257978   PMID:30456293   PMID:30472119   PMID:30482690   PMID:30559475   PMID:30727847  
PMID:30867247   PMID:30918408   PMID:30944354   PMID:30954227   PMID:31043586   PMID:31091127   PMID:31124076   PMID:31153646   PMID:31167127   PMID:31241990   PMID:31259693   PMID:31268770  
PMID:31328777   PMID:31609204   PMID:31666704   PMID:31682159   PMID:31742355   PMID:31746324   PMID:31805977   PMID:31806757   PMID:31863649   PMID:31955944   PMID:31969659   PMID:31989159  
PMID:31996852   PMID:32017713   PMID:32066723   PMID:32101284   PMID:32113678   PMID:32193098   PMID:32241803   PMID:32325033   PMID:32343709   PMID:32343840   PMID:32420617   PMID:32427844  
PMID:32580946   PMID:32602839   PMID:32656734   PMID:32661768   PMID:32693782   PMID:32841600   PMID:33016877   PMID:33288908   PMID:33335094   PMID:33434144   PMID:33500273   PMID:33653689  
PMID:33744254   PMID:33761312   PMID:33789083   PMID:33831408   PMID:33897893   PMID:33925396   PMID:33962017   PMID:34004146   PMID:34095148   PMID:34127535   PMID:34272903   PMID:34387544  
PMID:34433854   PMID:34616071   PMID:34644112   PMID:34657443   PMID:34705510   PMID:34720852   PMID:34730085   PMID:34994686   PMID:35006609   PMID:35014950   PMID:35177643   PMID:35333571  
PMID:35700329   PMID:35867816   PMID:36064547   PMID:36070775   PMID:36084555   PMID:36197968   PMID:36417873   PMID:36513018   PMID:37006472  


Genomics

Comparative Map Data
Nos1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395118,004,904 - 118,096,905 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5117,919,097 - 118,096,905 (+)EnsemblGRCm39 Ensembl
GRCm385117,866,839 - 117,958,840 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5117,781,032 - 117,958,840 (+)EnsemblGRCm38mm10GRCm38
MGSCv375118,317,128 - 118,403,822 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365118,128,149 - 118,214,843 (+)NCBIMGSCv36mm8
Celera5114,958,747 - 115,046,830 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map557.29NCBI
NOS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812117,208,142 - 117,361,626 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl12117,208,142 - 117,452,170 (-)EnsemblGRCh38hg38GRCh38
GRCh3712117,645,947 - 117,799,431 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612116,135,362 - 116,283,965 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412116,113,698 - 116,262,302NCBI
Celera12117,280,475 - 117,430,209 (-)NCBICelera
Cytogenetic Map12q24.22NCBI
HuRef12114,655,115 - 114,808,727 (-)NCBIHuRef
CHM1_112117,611,241 - 117,767,258 (-)NCBICHM1_1
T2T-CHM13v2.012117,189,186 - 117,342,679 (-)NCBIT2T-CHM13v2.0
Nos1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21238,615,111 - 38,795,492 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1238,626,714 - 38,710,945 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1239,802,061 - 39,886,285 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01240,415,854 - 40,500,100 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01239,468,822 - 39,553,063 (-)NCBIRnor_WKY
Rnor_6.01244,214,949 - 44,405,530 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1244,213,943 - 44,520,341 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01246,049,288 - 46,209,569 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41239,812,500 - 39,869,484 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11239,675,108 - 39,732,872 (-)NCBI
Celera1240,283,655 - 40,368,674 (-)NCBICelera
RH 3.4 Map12717.0RGD
RH 3.4 Map12718.8RGD
Cytogenetic Map12q16NCBI
Nos1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545513,797,545 - 13,972,566 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545513,797,557 - 13,978,402 (+)NCBIChiLan1.0ChiLan1.0
NOS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan112125,272,284 - 125,419,664 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012114,784,232 - 114,938,385 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112118,163,655 - 118,314,005 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12118,163,655 - 118,314,005 (-)Ensemblpanpan1.1panPan2
NOS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12613,787,341 - 13,895,176 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2613,786,309 - 13,962,332 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2613,781,845 - 13,865,309 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02614,042,033 - 14,222,209 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2614,044,400 - 14,151,070 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12614,009,781 - 14,093,258 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02614,087,144 - 14,170,688 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02614,122,943 - 14,206,510 (-)NCBIUU_Cfam_GSD_1.0
Nos1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118154,176,906 - 154,267,437 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365585,233,459 - 5,301,414 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365585,162,471 - 5,302,488 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1435,113,184 - 35,295,944 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11435,112,898 - 35,299,297 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21437,401,967 - 37,515,427 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NOS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111112,642,374 - 112,673,882 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037132,411,769 - 132,561,385 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nos1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474716,003,969 - 16,113,165 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474715,940,614 - 16,118,051 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nos1
2860 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3158
Count of miRNA genes:894
Interacting mature miRNAs:1241
Transcripts:ENSMUST00000086451, ENSMUST00000102557, ENSMUST00000124194, ENSMUST00000138554, ENSMUST00000138579, ENSMUST00000142742, ENSMUST00000171055
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575315348120018629Mouse
10043958Chldq12_mcholesterol and HDL QTL 12 (mouse)Not determined587386871121387065Mouse
1301126Bwem1_mbody weight day 30 males 1 (mouse)Not determined587386871121387065Mouse
13464241Ahl18_mage related hearing loss, early onset 18 (mouse)587386871121387065Mouse
1300801Drb2_mdopamine receptor binding 2 (mouse)Not determined587386871121387065Mouse
1301399Cpfd3_mcerebellum pattern fissures (mouse)Not determined587386871121387065Mouse
1357725Eae39_mexperimental allergic encephalomyelitis 39 (mouse)Not determined589418876118864028Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589418876124238239Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
11049562Lmr24f_mleishmaniasis resistance 24f (mouse)590320962124321041Mouse
1301457Cfsw2_mcystic fibrosis survival to weaning 2 (mouse)Not determined590561006124561151Mouse
1300993Hycdc_mhypercapnic duty cycle (mouse)Not determined590561006124561151Mouse
9587780Afw16_mabdominal fat weight QTL 16 (mouse)Not determined592830166126830285Mouse
1301974Chab7_mcholesterol absorption 7 (mouse)Not determined595233214129233330Mouse
1357644Egrd1_mearly growth rate, direct effect 1 (mouse)Not determined595434580129434786Mouse
10402486Dipa1_mdrug induced psychomotor activation 1 (mouse)Not determined595465549129465722Mouse
13464244Ahl19_mage related hearing loss, early onset 19 (mouse)595465549129465722Mouse
1558774Lith17_mlithogenic gene 17 (mouse)Not determined595465549129465722Mouse
1300940Actd3_mactivity-distance traveled 3 (mouse)Not determined596320385130320533Mouse
1300659Pcd8ts1_mp-glycoprotein positive CD8 T cell subset 1 (mouse)Not determined597021753131021986Mouse
1301858Smdq1_msegregation of mitochondrial DNA QTL 1 (mouse)Not determined597021753131021986Mouse
4141519Hmtb5_mhemostasis and thrombosis bleeding time 5 (mouse)Not determined99949422126882944Mouse
12904945Tammq2_mtibialis anterior muscle mass QTL 2 (mouse)5100665965134665965Mouse
12904959Smmq1_msoleus muscle mass QTL 1 (mouse)5100665965134665965Mouse
12859290Criq2_mCitrobacter rodentium infection QTL 2 (mouse)5101332579135332579Mouse
1301624Aevm2_mautoimmune extremity vasculitis in MRL mice 2 (mouse)Not determined5101863832135864028Mouse
14746986Manh58_mmandible shape 58 (mouse)5102446283136446283Mouse
11532736Sluc33b_msusceptibility to lung cancer 33b (mouse)5102945037136945196Mouse
11528550Sluc33_msusceptibility to lung cancer 33 (mouse)5104386871120711986Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104583688138555455Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104705939138705939Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse
4141139Hmtb4_mhemostasis and thrombosis rebleeding time 4 (mouse)Not determined108762509126882944Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109238624139118905Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
4141652Mrdq2_mmodifier of retinal degeneration QTL 2 (mouse)Not determined110253106118093673Mouse
1301102Cia14_mcollagen induced arthritis 14 (mouse)Not determined5113320385138555455Mouse
1357662Lprq4_mlipoprotein QTL 4 (mouse)Not determined5114021753129632606Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115156883149157015Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse

Markers in Region
D5Mit188  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385117,879,630 - 117,879,777UniSTSGRCm38
MGSCv375118,329,639 - 118,329,786UniSTSGRCm37
Celera5114,971,378 - 114,971,509UniSTS
Cytogenetic Map5FUniSTS
cM Map564.0UniSTS
Whitehead Genetic551.4UniSTS
Whitehead/MRC_RH51427.88UniSTS
D5Mit210  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385117,910,948 - 117,911,226UniSTSGRCm38
GRCm385117,911,019 - 117,911,226UniSTSGRCm38
MGSCv375118,360,957 - 118,361,235UniSTSGRCm37
MGSCv375118,361,028 - 118,361,235UniSTSGRCm37
Celera5115,003,727 - 115,004,023UniSTS
Celera5115,003,798 - 115,004,023UniSTS
Cytogenetic Map5FUniSTS
cM Map564.0UniSTS
cM Map5 UniSTS
Whitehead Genetic551.4UniSTS
D5Mit319  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385117,932,225 - 117,932,347UniSTSGRCm38
MGSCv375118,382,234 - 118,382,356UniSTSGRCm37
Celera5115,025,026 - 115,025,148UniSTS
Cytogenetic Map5FUniSTS
cM Map564.0UniSTS
Whitehead Genetic551.4UniSTS
Whitehead/MRC_RH51438.72UniSTS
Nos1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv375118,317,423 - 118,317,901UniSTSGRCm37
Celera5114,959,042 - 114,959,520UniSTS
Cytogenetic Map5FUniSTS
cM Map565.0UniSTS
cM Map565.0UniSTS
PMC311332P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385117,867,129 - 117,867,669UniSTSGRCm38
MGSCv375118,317,138 - 118,317,678UniSTSGRCm37
Celera5114,958,757 - 114,959,297UniSTS
Cytogenetic Map5FUniSTS
cM Map565.0UniSTS
PMC59521P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385117,900,498 - 117,900,585UniSTSGRCm38
MGSCv375118,350,507 - 118,350,594UniSTSGRCm37
Celera5114,993,278 - 114,993,365UniSTS
Cytogenetic Map5FUniSTS
cM Map565.0UniSTS
GDB:437697  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385117,867,490 - 117,867,929UniSTSGRCm38
MGSCv375118,317,499 - 118,317,938UniSTSGRCm37
Celera5114,959,118 - 114,959,557UniSTS
Cytogenetic Map5FUniSTS
cM Map565.0UniSTS
Nos1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5FUniSTS
cM Map565.0UniSTS
Nos1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385117,867,414 - 117,867,892UniSTSGRCm38
MGSCv375118,317,423 - 118,317,901UniSTSGRCm37
Celera5114,959,042 - 114,959,520UniSTS
Cytogenetic Map5FUniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000086451   ⟹   ENSMUSP00000138506
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5117,980,251 - 118,092,429 (+)Ensembl
GRCm38.p6 Ensembl5117,842,186 - 117,954,364 (+)Ensembl
RefSeq Acc Id: ENSMUST00000102557   ⟹   ENSMUSP00000099617
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5118,005,179 - 118,091,974 (+)Ensembl
GRCm38.p6 Ensembl5117,867,114 - 117,953,909 (+)Ensembl
RefSeq Acc Id: ENSMUST00000124194
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5117,919,120 - 118,005,151 (+)Ensembl
GRCm38.p6 Ensembl5117,781,055 - 117,867,086 (+)Ensembl
RefSeq Acc Id: ENSMUST00000138554
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5118,057,240 - 118,063,796 (+)Ensembl
GRCm38.p6 Ensembl5117,919,175 - 117,925,731 (+)Ensembl
RefSeq Acc Id: ENSMUST00000138579   ⟹   ENSMUSP00000138176
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5117,919,097 - 118,005,521 (+)Ensembl
GRCm38.p6 Ensembl5117,781,032 - 117,867,456 (+)Ensembl
RefSeq Acc Id: ENSMUST00000142742   ⟹   ENSMUSP00000120421
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5117,979,915 - 118,096,905 (+)Ensembl
GRCm38.p6 Ensembl5117,841,850 - 117,958,840 (+)Ensembl
RefSeq Acc Id: ENSMUST00000171055   ⟹   ENSMUSP00000127432
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5118,005,184 - 118,091,878 (+)Ensembl
GRCm38.p6 Ensembl5117,867,119 - 117,953,813 (+)Ensembl
RefSeq Acc Id: NM_008712   ⟹   NP_032738
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395118,004,904 - 118,096,905 (+)NCBI
GRCm385117,866,839 - 117,958,840 (+)NCBI
MGSCv375118,317,128 - 118,403,822 (+)RGD
Celera5114,958,747 - 115,046,830 (+)RGD
cM Map5 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032738   ⟸   NM_008712
- UniProtKB: Q64208 (UniProtKB/Swiss-Prot),   Q9Z0J4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000138506   ⟸   ENSMUST00000086451
RefSeq Acc Id: ENSMUSP00000138176   ⟸   ENSMUST00000138579
RefSeq Acc Id: ENSMUSP00000127432   ⟸   ENSMUST00000171055
RefSeq Acc Id: ENSMUSP00000120421   ⟸   ENSMUST00000142742
RefSeq Acc Id: ENSMUSP00000099617   ⟸   ENSMUST00000102557
Protein Domains
FAD-binding FR-type   Flavodoxin-like   PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z0J4-F1-model_v2 AlphaFold Q9Z0J4 1-1429 view protein structure

Promoters
RGD ID:6887820
Promoter ID:EPDNEW_M7361
Type:initiation region
Name:Nos1_1
Description:Mus musculus nitric oxide synthase 1, neuronal , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385117,949,587 - 117,949,647EPDNEW
RGD ID:6837954
Promoter ID:MM_KWN:43767
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:ENSMUST00000102557,   UC008ZFY.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365118,317,441 - 118,317,941 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97360 AgrOrtholog
Ensembl Genes ENSMUSG00000029361 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000099617.3 UniProtKB/TrEMBL
  ENSMUSP00000120421.2 UniProtKB/Swiss-Prot
  ENSMUSP00000127432 ENTREZGENE
  ENSMUSP00000127432.2 UniProtKB/Swiss-Prot
  ENSMUSP00000138176.2 UniProtKB/TrEMBL
  ENSMUSP00000138506.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000086451.12 UniProtKB/TrEMBL
  ENSMUST00000102557.10 UniProtKB/TrEMBL
  ENSMUST00000138579.3 UniProtKB/TrEMBL
  ENSMUST00000142742.9 UniProtKB/Swiss-Prot
  ENSMUST00000171055 ENTREZGENE
  ENSMUST00000171055.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.360 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.440.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.410 UniProtKB/TrEMBL
  Translation factors UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CysJ-like_FAD-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_FR_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavdoxin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavodoxin/NO_synth UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavoprot_Pyr_Nucl_cyt_Rdtase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavoprotein-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FNR_nucleotide-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADPH_Cyt_P450_Rdtase_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOS_dom_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOS_dom_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOS_dom_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOS_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOS_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOS_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OxRdtase_FAD/NAD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Riboflavin_synthase-like_b-brl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18125 UniProtKB/Swiss-Prot
MGD MGI:97360 ENTREZGENE
NCBI Gene 18125 ENTREZGENE
PANTHER NITRIC OXIDE SYNTHASE OXYGENASE UniProtKB/Swiss-Prot
  NITRIC OXIDE SYNTHASE OXYGENASE UniProtKB/Swiss-Prot
  NITRIC OXIDE SYNTHASE OXYGENASE UniProtKB/TrEMBL
  NITRIC OXIDE SYNTHASE OXYGENASE UniProtKB/TrEMBL
Pfam FAD_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavodoxin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NO_synthase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nos1 PhenoGen
PIRSF NOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS FLAVODOXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FPNCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FAD_FR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FLAVODOXIN_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52218 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52343 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56512 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF63380 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F8WGF2_MOUSE UniProtKB/TrEMBL
  NOS1_MOUSE UniProtKB/Swiss-Prot
  Q64208 ENTREZGENE
  Q9Z0J4 ENTREZGENE
  S4R1D5_MOUSE UniProtKB/TrEMBL
  S4R255_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3UR10 UniProtKB/Swiss-Prot
  Q64208 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Nos1  nitric oxide synthase 1, neuronal  2310005C01Rik  RIKEN cDNA 2310005C01 gene  Data Merged 737654 PROVISIONAL