Nog (noggin) - Rat Genome Database

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Gene: Nog (noggin) Mus musculus
Analyze
Symbol: Nog
Name: noggin
RGD ID: 10989
MGI Page MGI
Description: Predicted to enable cytokine binding activity and protein homodimerization activity. Involved in several processes, including cell surface receptor signaling pathway; heart morphogenesis; and modulation of chemical synaptic transmission. Acts upstream of or within several processes, including embryonic morphogenesis; nervous system development; and regulation of gene expression. Located in extracellular space. Is expressed in several structures, including embryo ectoderm; embryo mesenchyme; heart; sensory organ; and skeletal system. Used to study esophageal atresia/tracheoesophageal fistula. Human ortholog(s) of this gene implicated in Huntington's disease; bone disease (multiple); cleft lip; and hyperopia. Orthologous to human NOG (noggin).
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391189,191,464 - 89,193,385 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1189,191,464 - 89,193,158 (-)EnsemblGRCm39 Ensembl
GRCm381189,300,638 - 89,302,559 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1189,300,638 - 89,302,332 (-)EnsemblGRCm38mm10GRCm38
MGSCv371189,161,952 - 89,163,873 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361189,117,412 - 89,118,110 (-)NCBIMGSCv36mm8
Celera1198,919,523 - 98,921,373 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1154.34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(20S)-ginsenoside Rg3  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-palmitoylglycerol  (ISO)
3',5'-cyclic AMP  (EXP)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
acetic acid  (EXP)
acrylamide  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
amitriptyline  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromochloroacetic acid  (EXP)
butanal  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
D-glucose  (EXP)
DDE  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
folic acid  (EXP)
fructose  (EXP)
furan  (ISO)
glucose  (EXP)
glycerol 2-phosphate  (ISO)
herbicide  (EXP)
icariin  (EXP)
iron dichloride  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
maneb  (EXP)
manganese(II) chloride  (EXP)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methotrexate  (EXP)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (ISO)
neomycin  (EXP)
nickel atom  (ISO)
octreotide  (EXP)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pasireotide  (EXP)
pentane-2,3-dione  (ISO)
phenethyl caffeate  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salidroside  (EXP)
SB 431542  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
sulforaphane  (ISO)
testosterone  (EXP)
thimerosal  (ISO)
trametinib  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure formation involved in morphogenesis  (IGI,IMP)
atrial cardiac muscle tissue morphogenesis  (IMP)
axial mesoderm development  (IMP)
axon guidance  (IMP)
BMP signaling pathway  (IDA,IGI)
brain development  (IMP)
cartilage development  (IDA)
cell differentiation  (IEA)
cell differentiation in hindbrain  (ISO)
cell population proliferation  (IGI)
cellular response to BMP stimulus  (IDA,ISO)
cellular response to hypoxia  (ISO)
central nervous system development  (IMP)
cranial skeletal system development  (IGI)
dorsal/ventral pattern formation  (IBA,ISO)
embryonic digit morphogenesis  (ISO)
embryonic skeletal joint morphogenesis  (ISO)
embryonic skeletal system development  (ISO)
endocardial cushion formation  (IMP)
endoderm development  (IDA)
endoderm formation  (IDA)
epithelial cell proliferation  (IGI,IMP)
epithelial to mesenchymal transition  (IMP)
exploration behavior  (IMP)
face morphogenesis  (IMP)
fibroblast growth factor receptor signaling pathway  (IGI)
forebrain development  (IGI,ISO)
heart trabecula morphogenesis  (IMP)
hippocampus development  (ISO)
in utero embryonic development  (IMP)
limb development  (ISO)
long-term synaptic potentiation  (IMP)
lung morphogenesis  (IMP)
membranous septum morphogenesis  (IMP)
memory  (ISO)
mesenchymal cell differentiation  (IMP,ISO)
mesoderm formation  (IDA)
middle ear morphogenesis  (ISO)
motor neuron axon guidance  (IMP)
negative regulation of apoptotic signaling pathway  (IMP)
negative regulation of astrocyte differentiation  (IMP,ISO)
negative regulation of BMP signaling pathway  (IBA,IDA,IGI,IMP,ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cardiac epithelial to mesenchymal transition  (IMP)
negative regulation of cardiac muscle cell proliferation  (IMP)
negative regulation of cartilage development  (IDA)
negative regulation of cell differentiation  (IEA)
negative regulation of cell migration  (ISO)
negative regulation of cytokine activity  (ISO)
negative regulation of gene expression  (IDA)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of SMAD protein signal transduction  (ISO)
negative regulation of transcription by RNA polymerase II  (IMP)
neural plate anterior/posterior regionalization  (ISO)
neural plate morphogenesis  (IMP)
neural tube closure  (IMP)
neural tube development  (IMP)
nodal signaling pathway  (ISO)
notochord morphogenesis  (IMP)
ossification  (ISO)
osteoblast differentiation  (IBA,IMP)
outflow tract morphogenesis  (IMP)
pattern specification process  (IMP)
pharyngeal arch artery morphogenesis  (IMP)
pituitary gland development  (IMP)
positive regulation of branching involved in ureteric bud morphogenesis  (IDA)
positive regulation of cell population proliferation  (ISO)
positive regulation of epithelial cell proliferation  (IGI,IMP)
positive regulation of gene expression  (IMP)
positive regulation of glomerulus development  (IDA)
positive regulation of oligodendrocyte progenitor proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IGI)
presynaptic modulation of chemical synaptic transmission  (IDA)
prostatic bud formation  (IMP)
regulation of BMP signaling pathway  (IMP)
regulation of fibroblast growth factor receptor signaling pathway  (ISO)
regulation of neuronal synaptic plasticity  (IMP)
short-term synaptic potentiation  (IMP)
skeletal system development  (IMP)
smoothened signaling pathway  (IGI)
somatic stem cell population maintenance  (ISO)
somite development  (IMP)
spinal cord development  (IMP)
stem cell differentiation  (IMP)
ureteric bud development  (IDA)
ureteric bud formation  (IDA)
urogenital system development  (IMP)
ventricular compact myocardium morphogenesis  (IMP)
ventricular septum morphogenesis  (IMP)
visual learning  (IMP,ISO)
wound healing  (IMP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal anterior definitive endoderm morphology  (IAGP)
abnormal axial skeleton morphology  (IAGP)
abnormal basicranium morphology  (IAGP)
abnormal blood vessel morphology  (IEA)
abnormal bone mineralization  (IAGP)
abnormal bone structure  (IEA)
abnormal brain development  (IAGP)
abnormal cartilage development  (IAGP)
abnormal cartilage morphology  (IAGP)
abnormal caudal vertebrae morphology  (IEA)
abnormal cephalic neural fold morphology  (IAGP)
abnormal cochlea morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal diencephalon morphology  (IAGP)
abnormal direction of heart looping  (IAGP)
abnormal ear development  (IAGP)
abnormal embryo turning  (IEA)
abnormal embryonic tissue morphology  (IAGP)
abnormal esophagus development  (IAGP)
abnormal eye development  (IAGP)
abnormal facial morphology  (IAGP)
abnormal forebrain development  (IAGP)
abnormal foregut morphology  (IAGP)
abnormal frontal bone morphology  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal head development  (IAGP)
abnormal head morphology  (IAGP)
abnormal heart morphology  (IEA)
abnormal incus morphology  (IAGP)
abnormal interparietal bone morphology  (IAGP)
abnormal kidney morphology  (IEA)
abnormal left-right axis patterning  (IAGP)
abnormal limb bud morphology  (IAGP)
abnormal limb morphology  (IAGP)
abnormal lung development  (IAGP)
abnormal lung morphology  (IAGP)
abnormal male reproductive system morphology  (IAGP)
abnormal malleus morphology  (IAGP)
abnormal mesendoderm development  (IAGP)
abnormal middle ear morphology  (IAGP)
abnormal middle ear ossicle morphology  (IAGP)
abnormal muscle fiber morphology  (IAGP)
abnormal muscle morphology  (IAGP)
abnormal neural plate morphology  (IAGP)
abnormal neural tube closure  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal notochord morphology  (IAGP)
abnormal occipital bone morphology  (IAGP)
abnormal optic vesicle formation  (IEA)
abnormal parietal bone morphology  (IAGP)
abnormal pharyngeal arch morphology  (IEA)
abnormal pituitary gland development  (IAGP)
abnormal pituitary gland physiology  (IAGP)
abnormal placenta morphology  (IEA)
abnormal prechordal plate morphology  (IAGP)
abnormal primitive streak formation  (IAGP)
abnormal primitive urogenital sinus morphology  (IAGP)
abnormal prostate gland development  (IAGP)
abnormal prostate gland morphology  (IAGP)
abnormal Rathke's pouch apoptosis  (IAGP)
abnormal Rathke's pouch development  (IAGP)
abnormal rib morphology  (IAGP)
abnormal right lung morphology  (IAGP)
abnormal rostral-caudal patterning of the somites  (IAGP)
abnormal septation of the cloaca  (IAGP)
abnormal skeleton development  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal snout morphology  (IEA)
abnormal somite development  (IAGP)
abnormal somite shape  (IEA)
abnormal spinal cord morphology  (IAGP)
abnormal stapes morphology  (IAGP)
abnormal styloid process morphology  (IAGP)
abnormal tail development  (IAGP)
abnormal telencephalon morphology  (IAGP)
abnormal urethra morphology  (IAGP)
abnormal urinary system development  (IAGP)
abnormal vertebrae development  (IAGP)
abnormal vertebrae morphology  (IAGP)
abnormal vertebral arch morphology  (IAGP)
abnormal visceral yolk sac morphology  (IEA)
abnormal vitelline vasculature morphology  (IEA)
absent adenohypophysis  (IAGP)
absent bulbourethral gland  (IAGP)
absent mandible  (IAGP)
absent nasal placodes  (IAGP)
absent notochord  (IAGP)
absent pituitary gland  (IAGP)
absent pituitary infundibular stalk  (IAGP)
absent Rathke's pouch  (IAGP)
absent sclerotome  (IAGP)
absent tail  (IAGP)
absent vertebral arch  (IAGP)
anal atresia  (IAGP)
anophthalmia  (IAGP)
aprosencephaly  (IAGP)
conductive hearing loss  (IAGP)
cryptorchism  (IAGP)
cyclopia  (IAGP)
decreased cochlea coiling  (IAGP)
decreased embryo size  (IAGP)
decreased fetal size  (IAGP)
decreased forebrain size  (IAGP)
decreased prostate gland ventral lobe weight  (IAGP)
decreased somite size  (IAGP)
edema  (IAGP)
embryonic growth retardation  (IEA)
embryonic lethality between somite formation and embryo turning, incomplete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
esophageal atresia  (IAGP)
esophagus stenosis  (IAGP)
exencephaly  (IAGP)
fused synovial joints  (IAGP)
fusion of middle ear ossicles  (IAGP)
hematoma  (IAGP)
holoprosencephaly  (IAGP)
impaired hearing  (IAGP)
incomplete rostral neuropore closure  (IAGP)
increased apoptosis  (IAGP)
increased circulating alkaline phosphatase level  (IEA)
increased cochlear inner hair cell number  (IAGP)
increased cochlear outer hair cell number  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
kinked neural tube  (IAGP)
kinked tail  (IAGP)
kyphosis  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lumbar vertebral transformation  (IAGP)
no abnormal phenotype detected  (IAGP)
open neural tube  (IAGP)
pelvic kidney  (IAGP)
perinatal lethality  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
prenatal lethality  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
proboscis  (IAGP)
short face  (IAGP)
short limbs  (IAGP)
small kidney  (IEA)
small limb buds  (IAGP)
small pharynx  (IAGP)
small thoracic cage  (IAGP)
spina bifida occulta  (IAGP)
tracheoesophageal fistula  (IAGP)
vestigial tail  (IAGP)
wavy neural tube  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Activation of vascular bone morphogenetic protein signaling in diabetes mellitus. Bostrom KI, etal., Circ Res. 2011 Feb 18;108(4):446-57. doi: 10.1161/CIRCRESAHA.110.236596. Epub 2010 Dec 30.
2. Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington disease. Cho SR, etal., J Clin Invest. 2007 Oct;117(10):2889-902.
3. Stapes ankylosis in a family with a novel NOG mutation: otologic features of the facioaudiosymphalangism syndrome. Declau F, etal., Otol Neurotol. 2005 Sep;26(5):934-40.
4. Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis. Gong Y, etal., Nat Genet. 1999 Mar;21(3):302-4.
5. Polymorphisms of the noggin gene and mandibular micrognathia: a first approximation. Gutiérrez SJ, etal., Acta Odontol Latinoam. 2010;23(1):13-9.
6. Spinally upregulated noggin suppresses axonal and dendritic plasticity following dorsal rhizotomy. Hampton DW, etal., Exp Neurol. 2007 Mar;204(1):366-79. Epub 2006 Dec 22.
7. Noggin heterozygous mice: an animal model for congenital conductive hearing loss in humans. Hwang CH and Wu DK, Hum Mol Genet. 2008 Mar 15;17(6):844-53. Epub 2007 Dec 20.
8. Novel NOG mutation in Japanese patients with stapes ankylosis with broad thumbs and toes. Ishino T, etal., Eur J Med Genet. 2015 Sep;58(9):427-32. doi: 10.1016/j.ejmg.2015.06.005. Epub 2015 Jul 26.
9. A new subtype of brachydactyly type B caused by point mutations in the bone morphogenetic protein antagonist NOGGIN. Lehmann K, etal., Am J Hum Genet. 2007 Aug;81(2):388-96. Epub 2007 Jun 8.
10. Identification of functional variants for cleft lip with or without cleft palate in or near PAX7, FGFR2, and NOG by targeted sequencing of GWAS loci. Leslie EJ, etal., Am J Hum Genet. 2015 Mar 5;96(3):397-411. doi: 10.1016/j.ajhg.2015.01.004. Epub 2015 Feb 19.
11. Aberrant Bmp signaling and notochord delamination in the pathogenesis of esophageal atresia. Li Y, etal., Dev Dyn. 2007 Mar;236(3):746-54.
12. Identification of a novel NOG mutation in a Chinese family with proximal symphalangism. Liu F, etal., Clin Chim Acta. 2014 Feb 15;429:129-33. doi: 10.1016/j.cca.2013.12.004. Epub 2013 Dec 8.
13. BMP inhibition enhances axonal growth and functional recovery after spinal cord injury. Matsuura I, etal., J Neurochem. 2008 May;105(4):1471-9. doi: 10.1111/j.1471-4159.2008.05251.x. Epub 2008 Jan 24.
14. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
15. MGDs mouse GO annotations MGD data from the GO Consortium
16. MGD IEA MGD IEA
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalk. Paez-Pereda M, etal., Proc Natl Acad Sci U S A 2003 Feb 4;100(3):1034-9.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
21. Mouse MP Annotation Import Pipeline RGD automated import pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Medical treatment of craniosynostosis: recombinant Noggin inhibits coronal suture closure in the rat craniosynostosis model. Shen K, etal., Orthod Craniofac Res. 2009 Aug;12(3):254-62. doi: 10.1111/j.1601-6343.2009.01460.x.
25. Association between NOGGIN and SPRY2 polymorphisms and nonsyndromic cleft lip with or without cleft palate. Song T, etal., Am J Med Genet A. 2015 Jan;167A(1):137-41. doi: 10.1002/ajmg.a.36802. Epub 2014 Oct 22.
26. Mutations of the NOG gene in individuals with proximal symphalangism and multiple synostosis syndrome. Takahashi T, etal., Clin Genet. 2001 Dec;60(6):447-51.
27. Noggin and BMP4 co-modulate adult hippocampal neurogenesis in the APP(swe)/PS1(DeltaE9) transgenic mouse model of Alzheimer's disease. Tang J, etal., Biochem Biophys Res Commun. 2009 Jul 31;385(3):341-5. doi: 10.1016/j.bbrc.2009.05.067. Epub 2009 May 20.
28. Reduced production of noggin by immune cells of patients with relapsing-remitting multiple sclerosis. Urshansky N, etal., J Neuroimmunol. 2011 Mar;232(1-2):171-8. doi: 10.1016/j.jneuroim.2010.10.007. Epub 2010 Nov 26.
29. Identification of mammalian noggin and its expression in the adult nervous system. Valenzuela DM, etal., J Neurosci 1995 Sep;15(9):6077-84.
30. Ischemic acute renal failure induces the expression of a wide range of nephrogenic proteins. Villanueva S, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Apr;290(4):R861-70. Epub 2005 Nov 10.
31. Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice. Wu XB, etal., J Clin Invest. 2003 Sep;112(6):924-34.
32. Noggin inhibits hypoxia-induced proliferation by targeting store-operated calcium entry and transient receptor potential cation channels. Yang K, etal., Am J Physiol Cell Physiol. 2015 Jun 1;308(11):C869-78. doi: 10.1152/ajpcell.00349.2014. Epub 2015 Mar 4.
33. Functional analysis of alleged NOGGIN mutation G92E disproves its pathogenic relevance. Zimmer J, etal., PLoS One. 2012;7(4):e35062. doi: 10.1371/journal.pone.0035062. Epub 2012 Apr 18.
Additional References at PubMed
PMID:7675106   PMID:8575293   PMID:9006071   PMID:9405660   PMID:9449667   PMID:9585504   PMID:9600941   PMID:9603738   PMID:9634411   PMID:9808626   PMID:9811581   PMID:9811592  
PMID:10087923   PMID:10191100   PMID:10349636   PMID:10409502   PMID:10457010   PMID:10477293   PMID:10524628   PMID:10534616   PMID:10559902   PMID:10642791   PMID:10662648   PMID:10684250  
PMID:10688202   PMID:10769235   PMID:10780854   PMID:10780858   PMID:11042159   PMID:11076761   PMID:11076861   PMID:11118201   PMID:11134349   PMID:11158592   PMID:11217851   PMID:11330864  
PMID:11410366   PMID:11585810   PMID:11641247   PMID:11731460   PMID:11784076   PMID:11850178   PMID:11869287   PMID:11969257   PMID:12117821   PMID:12141440   PMID:12194849   PMID:12217322  
PMID:12223402   PMID:12361961   PMID:12397106   PMID:12413903   PMID:12414734   PMID:12421925   PMID:12435358   PMID:12466851   PMID:12477932   PMID:12633782   PMID:12646922   PMID:12647299  
PMID:12666204   PMID:12687003   PMID:12697704   PMID:12702649   PMID:12781691   PMID:12783783   PMID:12805214   PMID:12842913   PMID:12952897   PMID:14584896   PMID:14602679   PMID:14723846  
PMID:14973275   PMID:15081361   PMID:15084457   PMID:15110716   PMID:15147765   PMID:15196959   PMID:15199066   PMID:15252029   PMID:15371327   PMID:15378062   PMID:15509764   PMID:15590741  
PMID:15590934   PMID:15604102   PMID:15703886   PMID:15781699   PMID:15841179   PMID:15902307   PMID:15936916   PMID:15963767   PMID:15975920   PMID:15987774   PMID:16094489   PMID:16122729  
PMID:16127465   PMID:16141072   PMID:16141073   PMID:16195406   PMID:16330189   PMID:16389070   PMID:16503488   PMID:16517216   PMID:16537572   PMID:16538672   PMID:16540513   PMID:16598734  
PMID:16602821   PMID:16712836   PMID:16813523   PMID:16894609   PMID:16916379   PMID:16943278   PMID:16952347   PMID:17164417   PMID:17218603   PMID:17359964   PMID:17360443   PMID:17382312  
PMID:17400546   PMID:17522159   PMID:17576802   PMID:17609215   PMID:17618464   PMID:17634368   PMID:17693602   PMID:17900554   PMID:17904116   PMID:17913788   PMID:17959802   PMID:18003744  
PMID:18028109   PMID:18028901   PMID:18202659   PMID:18272846   PMID:18410737   PMID:18462699   PMID:18550712   PMID:18579678   PMID:18594453   PMID:18676816   PMID:18691704   PMID:18784300  
PMID:18830900   PMID:18832580   PMID:18930709   PMID:19097048   PMID:19097117   PMID:19103193   PMID:19141668   PMID:19252814   PMID:19341725   PMID:19389359   PMID:19389368   PMID:19393343  
PMID:19439426   PMID:19460349   PMID:19700758   PMID:19850029   PMID:19852960   PMID:20034104   PMID:20063299   PMID:20357001   PMID:20359476   PMID:20386748   PMID:20501701   PMID:20508035  
PMID:20522595   PMID:20654612   PMID:20689554   PMID:20727875   PMID:20730911   PMID:20795361   PMID:21068065   PMID:21192082   PMID:21211521   PMID:21267068   PMID:21303853   PMID:21445260  
PMID:21509901   PMID:21624478   PMID:21658585   PMID:21750028   PMID:21801425   PMID:21821669   PMID:21873635   PMID:21953591   PMID:22071110   PMID:22072987   PMID:22076636   PMID:22297545  
PMID:22302143   PMID:22334719   PMID:22340494   PMID:22351751   PMID:22370001   PMID:22417325   PMID:22465667   PMID:22547067   PMID:22560297   PMID:22621191   PMID:22689267   PMID:22711842  
PMID:22750402   PMID:22911573   PMID:23038774   PMID:23103586   PMID:23213481   PMID:23313125   PMID:23344708   PMID:23499659   PMID:23563729   PMID:23592779   PMID:23824574   PMID:23863486  
PMID:23891934   PMID:23977305   PMID:24098149   PMID:24186978   PMID:24336726   PMID:24370450   PMID:24371086   PMID:24514266   PMID:24631216   PMID:24835669   PMID:24949938   PMID:24952961  
PMID:24995796   PMID:25043193   PMID:25249463   PMID:25428115   PMID:25428587   PMID:25514040   PMID:25605781   PMID:25758226   PMID:25774506   PMID:25977363   PMID:26064939   PMID:26721501  
PMID:26952187   PMID:26984772   PMID:27030100   PMID:27144312   PMID:27573479   PMID:27713395   PMID:27756203   PMID:27769098   PMID:28846100   PMID:29094227   PMID:29467244   PMID:29771958  
PMID:30021842   PMID:30228991   PMID:30235284   PMID:30244870   PMID:30352848   PMID:30854720   PMID:31027994   PMID:31038803   PMID:31311865   PMID:31539501   PMID:31862386   PMID:31932950  
PMID:32427591   PMID:33117338   PMID:34298323   PMID:34610275   PMID:36137018   PMID:36790128   PMID:36916392   PMID:38175868   PMID:38300806   PMID:38355793  


Genomics

Comparative Map Data
Nog
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391189,191,464 - 89,193,385 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1189,191,464 - 89,193,158 (-)EnsemblGRCm39 Ensembl
GRCm381189,300,638 - 89,302,559 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1189,300,638 - 89,302,332 (-)EnsemblGRCm38mm10GRCm38
MGSCv371189,161,952 - 89,163,873 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361189,117,412 - 89,118,110 (-)NCBIMGSCv36mm8
Celera1198,919,523 - 98,921,373 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1154.34NCBI
NOG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381756,593,699 - 56,595,611 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1756,593,699 - 56,595,611 (+)EnsemblGRCh38hg38GRCh38
GRCh371754,671,060 - 54,672,972 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361752,026,274 - 52,027,546 (+)NCBINCBI36Build 36hg18NCBI36
Build 341752,026,273 - 52,027,542NCBI
Celera1751,132,757 - 51,134,648 (+)NCBICelera
Cytogenetic Map17q22NCBI
HuRef1750,031,838 - 50,033,727 (+)NCBIHuRef
CHM1_11754,735,932 - 54,737,820 (+)NCBICHM1_1
T2T-CHM13v2.01757,469,821 - 57,471,732 (+)NCBIT2T-CHM13v2.0
Nog
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81074,625,874 - 74,627,501 (-)NCBIGRCr8
mRatBN7.21074,128,712 - 74,130,339 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1074,128,712 - 74,130,339 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1078,757,906 - 78,759,533 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01078,262,852 - 78,264,479 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01073,730,695 - 73,732,322 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01076,811,759 - 76,813,386 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1076,811,759 - 76,813,386 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01076,677,612 - 76,679,239 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41077,689,244 - 77,690,871 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11077,703,801 - 77,704,728 (-)NCBI
Celera1073,029,127 - 73,030,754 (-)NCBICelera
Cytogenetic Map10q26NCBI
Nog
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554516,193,042 - 6,193,740 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554516,192,368 - 6,193,766 (-)NCBIChiLan1.0ChiLan1.0
NOG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21972,764,735 - 72,767,331 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11777,576,197 - 77,577,597 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01750,669,186 - 50,671,081 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11755,532,208 - 55,533,782 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1755,532,394 - 55,533,092 (+)Ensemblpanpan1.1panPan2
NOG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1931,453,604 - 31,456,060 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha930,695,378 - 30,696,228 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0932,262,855 - 32,263,712 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl932,262,940 - 32,263,663 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1931,048,413 - 31,049,269 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0931,332,204 - 31,333,060 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0931,415,982 - 31,416,833 (+)NCBIUU_Cfam_GSD_1.0
Nog
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560230,811,040 - 30,812,486 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364906,262,785 - 6,263,483 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364906,262,651 - 6,264,069 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1232,891,321 - 32,892,206 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11232,891,321 - 32,892,206 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NOG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11636,816,783 - 36,818,693 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1636,817,476 - 36,818,174 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660777,642,384 - 7,644,356 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nog
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479511,696,353 - 11,697,051 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479511,696,102 - 11,697,367 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nog
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:242
Count of miRNA genes:190
Interacting mature miRNAs:213
Transcripts:ENSMUST00000061728
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187691198103274115Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
15092049Wsigrme3_mweek six growth rate, maternal effect 3 (mouse)118487732496629512Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
15092057Lgrme3_mlate growth rate, maternal effect 3 (mouse)118487732496629512Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1301491Abbp4_mA/J and C57BL/6 blood pressure 4 (mouse)Not determined118869958899081597Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117757387399377820Mouse

Markers in Region
RH66786  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381189,301,337 - 89,301,494UniSTSGRCm38
MGSCv371189,162,651 - 89,162,808UniSTSGRCm37
Celera1198,920,222 - 98,920,379UniSTS
Cytogenetic Map11CUniSTS
cM Map1150.5UniSTS
Nog  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381189,301,582 - 89,301,942UniSTSGRCm38
MGSCv371189,162,896 - 89,163,256UniSTSGRCm37
Celera1198,920,467 - 98,920,827UniSTS
Cytogenetic Map11CUniSTS
cM Map1150.5UniSTS
NOG_2549  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381189,300,977 - 89,301,665UniSTSGRCm38
MGSCv371189,162,291 - 89,162,979UniSTSGRCm37
Celera1198,919,862 - 98,920,550UniSTS
Cytogenetic Map11CUniSTS
cM Map1150.5UniSTS
PMC316831P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381189,301,811 - 89,302,022UniSTSGRCm38
MGSCv371189,163,125 - 89,163,336UniSTSGRCm37
Celera1198,920,696 - 98,920,907UniSTS
Cytogenetic Map11CUniSTS
cM Map1150.5UniSTS
UniSTS:489090  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381189,301,322 - 89,302,020UniSTSGRCm38
MGSCv371189,162,636 - 89,163,334UniSTSGRCm37
Celera1198,920,207 - 98,920,905UniSTS
Cytogenetic Map11CUniSTS
cM Map1150.5UniSTS
UniSTS:495034  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381189,301,271 - 89,302,085UniSTSGRCm38
MGSCv371189,162,585 - 89,163,399UniSTSGRCm37
Celera1198,920,156 - 98,920,970UniSTS
Cytogenetic Map11CUniSTS
cM Map1150.5UniSTS
Nog  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11CUniSTS
Nog  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381189,301,325 - 89,301,846UniSTSGRCm38
MGSCv371189,162,639 - 89,163,160UniSTSGRCm37
Celera1198,920,210 - 98,920,731UniSTS
Cytogenetic Map11CUniSTS


Expression


Sequence


Ensembl Acc Id: ENSMUST00000061728   ⟹   ENSMUSP00000061427
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1189,191,464 - 89,193,158 (-)Ensembl
GRCm38.p6 Ensembl1189,300,638 - 89,302,332 (-)Ensembl
RefSeq Acc Id: NM_008711   ⟹   NP_032737
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391189,191,464 - 89,193,385 (-)NCBI
GRCm381189,300,638 - 89,302,559 (-)ENTREZGENE
MGSCv371189,161,952 - 89,163,873 (-)RGD
Celera1198,919,523 - 98,921,373 (-)RGD
cM Map11 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_032737 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB38281 (Get FASTA)   NCBI Sequence Viewer  
  AAI32528 (Get FASTA)   NCBI Sequence Viewer  
  AAI38149 (Get FASTA)   NCBI Sequence Viewer  
  EDL15873 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000061427
  ENSMUSP00000061427.4
GenBank Protein P97466 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_032737   ⟸   NM_008711
- Peptide Label: precursor
- UniProtKB: P97466 (UniProtKB/Swiss-Prot),   A2RTJ4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000061427   ⟸   ENSMUST00000061728

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97466-F1-model_v2 AlphaFold P97466 1-232 view protein structure

Promoters
RGD ID:8676138
Promoter ID:EPDNEW_M16099
Type:multiple initiation site
Name:Nog_1
Description:Mus musculus noggin , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381189,302,555 - 89,302,615EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104327 AgrOrtholog
Ensembl Genes ENSMUSG00000048616 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000061728 ENTREZGENE
  ENSMUST00000061728.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helix hairpin bin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Noggin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18121 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:104327 ENTREZGENE
NCBI Gene 18121 ENTREZGENE
PANTHER NOGGIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Noggin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nog PhenoGen
PIRSF Noggin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2RTJ4 ENTREZGENE, UniProtKB/TrEMBL
  NOGG_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE