Muc2 (mucin 2) - Rat Genome Database

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Gene: Muc2 (mucin 2) Mus musculus
Analyze
Symbol: Muc2
Name: mucin 2
RGD ID: 10928
MGI Page MGI
Description: An extracellular matrix structural constituent. Involved in host-mediated regulation of intestinal microbiota composition; maintenance of gastrointestinal epithelium; and mucus secretion. Acts upstream of or within several processes, including epithelial cell development; negative regulation of cell migration; and positive regulation of apoptotic process. Located in extracellular matrix; inner mucus layer; and outer mucus layer. Is active in mucus layer. Is expressed in hindgut epithelium and intestine. Used to study inflammatory bowel disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human MUC2 (mucin 2, oligomeric mucus/gel-forming).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2010015E03Rik; colonic mucin; MCM; MUC-2; mucin-2; secreted gel-forming mucin; wnn
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397141,276,583 - 141,308,428 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7141,276,583 - 141,308,430 (+)EnsemblGRCm39 Ensembl
GRCm387141,690,340 - 141,754,691 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,690,340 - 141,754,693 (+)EnsemblGRCm38mm10GRCm38
MGSCv377148,930,517 - 148,940,598 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv377148,876,261 - 148,890,250 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367141,553,920 - 141,565,981 (+)NCBIMGSCv36mm8
Celera7141,484,086 - 141,510,531 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map787.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
1,8-cineole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2-palmitoylglycerol  (ISO)
4,4'-sulfonyldiphenol  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aflatoxin M1  (ISO)
all-trans-4-hydroxyretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
amphotericin B  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
benzylpenicillin  (EXP)
biochanin A  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP)
cannabidiol  (EXP)
carmustine  (ISO)
chlorothalonil  (EXP)
chlorpyrifos  (ISO)
cholic acid  (ISO)
clodronic acid  (EXP)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (EXP)
dextran sulfate  (EXP)
diarsenic trioxide  (EXP)
diisononyl phthalate  (EXP)
disodium selenite  (EXP)
dodecanoic acid  (EXP)
enilconazole  (EXP)
erythromycin A  (EXP)
ethyl methanesulfonate  (ISO)
ethylparaben  (ISO)
fluoranthene  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
furan  (ISO)
genistein  (EXP)
Lafutidine  (ISO)
lipopolysaccharide  (ISO)
loxoprofen  (ISO)
mercury atom  (EXP)
mercury(0)  (EXP)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
microcystin-LR  (ISO)
Muraglitazar  (ISO)
N-nitrosodiethylamine  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (EXP)
procymidone  (EXP)
quercetin  (ISO)
sodium arsenite  (ISO)
sulfasalazine  (ISO)
Sunset Yellow FCF  (EXP)
T-2 toxin  (ISO)
Tesaglitazar  (ISO)
triptonide  (EXP)
troglitazone  (ISO)
valproic acid  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cell migration  (IAGP)
abnormal cell physiology  (IAGP)
abnormal colon morphology  (IAGP)
abnormal digestive system physiology  (IAGP)
abnormal endoplasmic reticulum morphology  (IAGP)
abnormal enterocyte morphology  (IAGP)
abnormal enterocyte proliferation  (IAGP)
abnormal intestinal absorption  (IEA)
abnormal intestinal goblet cell morphology  (IAGP)
abnormal intestinal mucosa morphology  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal intestine physiology  (IAGP)
abnormal large intestine crypts of Lieberkuhn morphology  (IAGP)
abnormal mitochondrial crista morphology  (IAGP)
colitis  (IAGP)
decreased colon length  (IAGP)
decreased enterocyte apoptosis  (IAGP)
decreased hematocrit  (IAGP)
diarrhea  (IEA)
dilated mitochondrion  (IAGP)
enlarged lymph nodes  (IEA)
gastrointestinal hemorrhage  (IAGP)
ileum inflammation  (IAGP)
increased cell proliferation  (IAGP)
increased circulating triglyceride level  (IAGP)
increased endoplasmic reticulum stress  (IAGP)
increased enterocyte apoptosis  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased interleukin-1 beta secretion  (IAGP)
increased interleukin-13 secretion  (IAGP)
increased intestinal adenocarcinoma incidence  (IAGP)
increased leukocyte cell number  (IAGP)
increased lymphocyte cell number  (IAGP)
increased susceptibility to induced colitis  (IAGP)
increased susceptibility to weight loss  (IAGP)
increased susceptibility to xenobiotic induced morbidity/mortality  (IAGP)
increased tumor necrosis factor secretion  (IAGP)
intestinal ulcer  (IAGP)
large intestinal inflammation  (IAGP)
melena  (IAGP)
premature death  (IAGP)
rectal hemorrhage  (IAGP)
rectal prolapse  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Pathogenesis of colloid (pure mucinous) carcinoma of exocrine organs: Coupling of gel-forming mucin (MUC2) production with altered cell polarity and abnormal cell-stroma interaction may be the key factor in the morphogenesis and indolent behavior of colloid carcinoma in the breast and pancreas. Adsay NV, etal., Am J Surg Pathol. 2003 May;27(5):571-8.
2. Intestinal anti-inflammatory activity of hydroalcoholic extracts of Phlomis purpurea L. and Phlomis lychnitis L. in the trinitrobenzenesulphonic acid model of rat colitis. Algieri F, etal., J Ethnopharmacol. 2013 Apr 19;146(3):750-9. doi: 10.1016/j.jep.2013.01.041. Epub 2013 Feb 7.
3. New therapeutic strategy for amino acid medicine: prophylactic and healing promoting effect of monosodium glutamate against NSAID-induced enteropathy. Amagase K, etal., J Pharmacol Sci. 2012;118(2):131-7. Epub 2012 Jan 27.
4. Altered Innate Defenses in the Neonatal Gastrointestinal Tract in Response to Colonization by Neuropathogenic Escherichia coli. Birchenough GM, etal., Infect Immun. 2013 Sep;81(9):3264-75. doi: 10.1128/IAI.00268-13. Epub 2013 Jun 24.
5. Homeostasis and function of goblet cells during rotavirus infection in mice. Boshuizen JA, etal., Virology. 2005 Jul 5;337(2):210-21.
6. Mucinous nonneoplastic cyst of the pancreas: apomucin phenotype distinguishes this entity from intraductal papillary mucinous neoplasm. Cao W, etal., Hum Pathol. 2010 Apr;41(4):513-21. Epub 2009 Dec 1.
7. Phenotypic alterations of mucins and cytokeratins during gallbladder carcinogenesis. Chang HJ, etal., Pathol Int. 2004 Aug;54(8):576-84.
8. Breakdown of mucin as barrier to digestive enzymes in the ischemic rat small intestine. Chang M, etal., PLoS One. 2012;7(6):e40087. doi: 10.1371/journal.pone.0040087. Epub 2012 Jun 29.
9. Therapeutic effects of rectal administration of muscovite on experimental colitis in rats. Chen Y, etal., J Gastroenterol Hepatol. 2009 May;24(5):912-9. Epub 2009 Feb 9.
10. A Decoy Oligonucleotide to NF-kappaB Delivered through Inhalable Particles Prevents LPS-Induced Rat Airway Inflammation. De Stefano D, etal., Am J Respir Cell Mol Biol. 2013 Aug;49(2):288-95. doi: 10.1165/rcmb.2012-0473OC.
11. Tumor necrosis factor-alpha and Muc2 mucin play major roles in disease onset and progression in dextran sodium sulphate-induced colitis. Dharmani P, etal., PLoS One. 2011;6(9):e25058. doi: 10.1371/journal.pone.0025058. Epub 2011 Sep 19.
12. Alterations of the ocular surface epithelial mucins 1, 2, 4 and the tear functions in patients with atopic keratoconjunctivitis. Dogru M, etal., Clin Exp Allergy. 2006 Dec;36(12):1556-65.
13. Intrauterine growth restriction alters postnatal colonic barrier maturation in rats. Fanca-Berthon P, etal., Pediatr Res. 2009 Jul;66(1):47-52. doi: 10.1203/PDR.0b013e3181a2047e.
14. Mucin production and composition is altered in dextran sulfate sodium-induced colitis in rats. Faure M, etal., Dig Dis Sci. 2003 Jul;48(7):1366-73.
15. Gene expression profile and genomic alterations in colonic tumours induced by 1,2-dimethylhydrazine (DMH) in rats. Femia AP, etal., BMC Cancer. 2010 May 11;10:194. doi: 10.1186/1471-2407-10-194.
16. K-ras mutations and mucin profile in preneoplastic lesions and colon tumors induced in rats by 1,2-dimethylhydrazine. Femia AP, etal., Int J Cancer. 2008 Jan 1;122(1):117-23.
17. Mucin gene deficiency in mice impairs host resistance to an enteric parasitic infection. Hasnain SZ, etal., Gastroenterology. 2010 May;138(5):1763-71. doi: 10.1053/j.gastro.2010.01.045. Epub 2010 Feb 4.
18. Tumor necrosis factor-alpha induces the aberrant expression of mucus core protein-2 in non-neoplastic biliary epithelial cells via the upregulation of CDX2 in chronic cholangitis. Ikeda H, etal., Hepatol Res. 2008 Oct;38(10):1006-17. Epub 2008 May 27.
19. Aberrant expression of CDX2 is closely related to the intestinal metaplasia and MUC2 expression in intraductal papillary neoplasm of the liver in hepatolithiasis. Ishikawa A, etal., Lab Invest. 2004 May;84(5):629-38.
20. Differences in the expression of mucins in various forms of cystitis glandularis. Jankovic Velickovic L, etal., Pathol Res Pract. 2007;203(9):653-8. Epub 2007 Jul 30.
21. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
22. Bifidobacterium bifidum improves intestinal integrity in a rat model of necrotizing enterocolitis. Khailova L, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Aug 27.
23. Altered mucin gene expression in stone-containing intrahepatic bile ducts and cholangiocarcinomas. Lee KT and Liu TS, Dig Dis Sci. 2001 Oct;46(10):2166-72.
24. Localization and up-regulation of mucin (MUC2) gene expression in human nasal biopsies of patients with cystic fibrosis. Li D, etal., J Pathol. 1997 Mar;181(3):305-10.
25. Fate of goblet cells in experimental colitis. Makkink MK, etal., Dig Dis Sci. 2002 Oct;47(10):2286-97.
26. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
27. MGDs mouse GO annotations MGD data from the GO Consortium
28. MGD IEA MGD IEA
29. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
30. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
31. Mouse MP Annotation Import Pipeline RGD automated import pipeline
32. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. Milk casein-based diet containing TGF-beta controls the inflammatory reaction in the HLA-B27 transgenic rat model. Schiffrin EJ, et al., JPEN J Parenter Enteral Nutr. 2005 Jul-Aug;29(4 Suppl):S141-8; discussion S149-50, S184-8.
35. Temporal analysis of goblet cells and mucin gene expression in murine models of allergic asthma. Shahzeidi S, etal., Exp Lung Res. 2003 Dec;29(8):549-65.
36. Irinotecan-induced mucositis is associated with changes in intestinal mucins. Stringer AM, etal., Cancer Chemother Pharmacol. 2008 Nov 8.
37. CDX2, COX2 and MUC2 expressions in Barrett's esophagus: can they be useful in determination of the dysplasia? Turkmen IC, etal., Turk Patoloji Derg. 2012;28(3):251-8. doi: 10.5146/tjpath.2012.01132.
38. Polymorphism of human mucin genes in chest disease: possible significance of MUC2. Vinall LE, etal., Am J Respir Cell Mol Biol. 2000 Nov;23(5):678-86.
39. [Effects of platelet activating factor receptor antagonist in intestinal mucin-2 during endotoxemia on young rats]. Wang LJ and Sun M, Zhonghua Er Ke Za Zhi. 2008 Sep;46(9):680-3.
40. Diagnostic value of mucins (MUC1, MUC2 and MUC5AC) expression profile in endoscopic ultrasound-guided fine-needle aspiration specimens of the pancreas. Wang Y, etal., Int J Cancer. 2007 Dec 15;121(12):2716-22.
41. Expression of MUC2 and MUC4 proteins and cytokines: early markers of intestinal graft rejection. Wasserberg N, etal., Transplantation. 2003 Apr 27;75(8):1249-55.
42. Expulsion of the gastrointestinal cestode, Hymenolepis diminuta by tolerant rats: evidence for mediation by a Th2 type immune enhanced goblet cell hyperplasia, increased mucin production and secretion. Webb RA, etal., Parasite Immunol. 2007 Jan;29(1):11-21.
43. Intestinal microbiota and innate immunity-related gene alteration in cirrhotic rats with liver transplantation. Xie YR, etal., Transplant Proc. 2011 Dec;43(10):3973-9. doi: 10.1016/j.transproceed.2011.08.113.
44. Altered expression of goblet cell- and mucin glycosylation-related genes in the intestinal epithelium during infection with the nematode Nippostrongylus brasiliensis in rat. Yamauchi J, etal., APMIS. 2006 Apr;114(4):270-8.
Additional References at PubMed
PMID:9886986   PMID:10198352   PMID:10349636   PMID:10611155   PMID:11042159   PMID:11076861   PMID:11212251   PMID:11352827   PMID:11872843   PMID:12040188   PMID:12477932   PMID:12676567  
PMID:14984930   PMID:15240568   PMID:15541382   PMID:15793302   PMID:15809042   PMID:16141072   PMID:16141073   PMID:16354691   PMID:16618389   PMID:16831596   PMID:16951258   PMID:17484881  
PMID:18035521   PMID:18198997   PMID:18318598   PMID:18336786   PMID:18356571   PMID:18427556   PMID:18480826   PMID:18794118   PMID:18806221   PMID:18829535   PMID:19037975   PMID:19110483  
PMID:19232344   PMID:19389805   PMID:19411636   PMID:19432394   PMID:19502996   PMID:19549527   PMID:20485566   PMID:20691176   PMID:20737421   PMID:21107311   PMID:21109593   PMID:21267068  
PMID:21356364   PMID:21670299   PMID:21677750   PMID:21700902   PMID:21831773   PMID:21873635   PMID:22159717   PMID:22162748   PMID:22261557   PMID:22341463   PMID:22387004   PMID:22451922  
PMID:22675208   PMID:22723890   PMID:22766025   PMID:23357502   PMID:23386727   PMID:23650437   PMID:23776564   PMID:23832516   PMID:23832517   PMID:23876803   PMID:24072822   PMID:24367558  
PMID:24680895   PMID:24694941   PMID:24929016   PMID:24941171   PMID:24945909   PMID:25114233   PMID:25166914   PMID:25322805   PMID:25349142   PMID:25378482   PMID:25437806   PMID:25495347  
PMID:26023099   PMID:26121642   PMID:26431380   PMID:26589109   PMID:26813339   PMID:27019864   PMID:27277677   PMID:27339979   PMID:27371534   PMID:27736991   PMID:27856417   PMID:27881401  
PMID:28069814   PMID:28106824   PMID:28122822   PMID:28434344   PMID:28604600   PMID:28738073   PMID:28796256   PMID:28823873   PMID:28943327   PMID:29249464   PMID:29361518   PMID:29401627  
PMID:29545196   PMID:29636525   PMID:29684311   PMID:29698056   PMID:29887318   PMID:30019213   PMID:30231491   PMID:30666958   PMID:31092921   PMID:31570526   PMID:31733832   PMID:31748792  
PMID:31776290   PMID:31781038   PMID:31980623   PMID:32141795   PMID:32340123   PMID:32540993   PMID:32659381   PMID:32747435   PMID:33031746   PMID:33093110   PMID:33273633   PMID:33431687  
PMID:33431704   PMID:33559155   PMID:33728986   PMID:33822948   PMID:34126068   PMID:34348153   PMID:34391772   PMID:34494458   PMID:34639039   PMID:34973372   PMID:35314399   PMID:35337837  
PMID:35527372   PMID:35682851   PMID:35830795   PMID:36175462   PMID:36189989   PMID:36499472   PMID:36504079   PMID:36584066   PMID:36639541   PMID:36753416   PMID:37359538   PMID:37385587  
PMID:37526424   PMID:37556321   PMID:37835487   PMID:37967555   PMID:38199279   PMID:38423356   PMID:39015786   PMID:39138000   PMID:39557858  


Genomics

Comparative Map Data
Muc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397141,276,583 - 141,308,428 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7141,276,583 - 141,308,430 (+)EnsemblGRCm39 Ensembl
GRCm387141,690,340 - 141,754,691 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,690,340 - 141,754,693 (+)EnsemblGRCm38mm10GRCm38
MGSCv377148,930,517 - 148,940,598 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv377148,876,261 - 148,890,250 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367141,553,920 - 141,565,981 (+)NCBIMGSCv36mm8
Celera7141,484,086 - 141,510,531 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map787.1NCBI
MUC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,074,874 - 1,110,508 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,074,875 - 1,110,511 (+)EnsemblGRCh38hg38GRCh38
GRCh37111,074,874 - 1,104,416 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,064,902 - 1,094,419 (+)NCBINCBI36Build 36hg18NCBI36
Build 34111,064,874 - 1,094,416NCBI
Cytogenetic Map11p15.5NCBI
HuRef11897,783 - 932,205 (+)NCBIHuRef
CHM1_1111,073,796 - 1,103,733 (+)NCBICHM1_1
T2T-CHM13v2.0111,144,674 - 1,182,053 (+)NCBIT2T-CHM13v2.0
Muc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81206,225,775 - 206,261,280 (+)NCBIGRCr8
GRCr8 Ensembl1206,229,035 - 206,261,280 (+)EnsemblGRCr8 Ensembl
mRatBN7.21196,799,494 - 196,831,740 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,799,517 - 196,831,756 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01214,663,929 - 214,693,197 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,664,537 - 214,693,043 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01221,581,822 - 221,611,451 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1194,430,946 - 194,458,668 (+)NCBICelera
Celera1194,458,772 - 194,461,359 (+)NCBICelera
Cytogenetic Map1q41NCBI
Muc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547611,108,826 - 11,135,697 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547611,108,826 - 11,135,697 (-)NCBIChiLan1.0ChiLan1.0
MUC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v293,487,647 - 3,523,891 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,698,364 - 2,735,182 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0111,106,716 - 1,144,489 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,143,625 - 1,180,798 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,143,625 - 1,169,741 (+)Ensemblpanpan1.1panPan2
MUC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11845,416,347 - 45,438,226 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ROS_Cfam_1.01846,091,348 - 46,116,933 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11845,539,151 - 45,565,262 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01845,119,185 - 45,145,631 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01845,857,452 - 45,883,423 (+)NCBIUU_Cfam_GSD_1.0
Muc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947806,466 - 835,556 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493681660,499 - 91,628 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493681660,499 - 91,628 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MUC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2689,364 - 710,330 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12689,363 - 719,542 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140 - 7,521 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MUC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11893,554 - 926,854 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603898,020,755 - 98,058,827 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Muc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476621,493,125 - 21,522,535 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Muc2
1266 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:69
Count of miRNA genes:66
Interacting mature miRNAs:67
Transcripts:ENSMUST00000026590
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127311241144995196Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127398151144995196Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
14746988Manh63_mmandible shape 63 (mouse)7127735437144995196Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse

Markers in Region
Muc2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387141,745,658 - 141,746,718UniSTSGRCm38
MGSCv377148,931,563 - 148,932,623UniSTSGRCm37
Celera7141,501,295 - 141,502,355UniSTS
Cytogenetic Map7F5UniSTS
cM Map768.99UniSTS
Muc2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_023566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC164070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC175487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF016695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF080584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF121215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF221746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ010437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ511872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ511873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ511874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC030862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC034197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC036168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC036170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC039284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC039285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LXEJ02004842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000026590   ⟹   ENSMUSP00000026590
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7141,746,832 - 141,754,690 (+)Ensembl
Ensembl Acc Id: ENSMUST00000167366   ⟹   ENSMUSP00000128250
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7141,699,186 - 141,701,375 (+)Ensembl
Ensembl Acc Id: ENSMUST00000179227   ⟹   ENSMUSP00000136692
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7141,695,703 - 141,697,247 (+)Ensembl
Ensembl Acc Id: ENSMUST00000185406   ⟹   ENSMUSP00000141040
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7141,276,583 - 141,308,430 (+)Ensembl
GRCm38.p6 Ensembl7141,690,340 - 141,698,782 (+)Ensembl
Ensembl Acc Id: ENSMUST00000185823   ⟹   ENSMUSP00000140855
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7141,699,186 - 141,701,484 (+)Ensembl
Ensembl Acc Id: ENSMUST00000187789   ⟹   ENSMUSP00000140349
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7141,702,097 - 141,702,775 (+)Ensembl
Ensembl Acc Id: ENSMUST00000187945   ⟹   ENSMUSP00000141128
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7141,744,612 - 141,754,693 (+)Ensembl
Ensembl Acc Id: ENSMUST00000191587   ⟹   ENSMUSP00000139657
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7141,704,165 - 141,704,611 (+)Ensembl
RefSeq Acc Id: NM_023566   ⟹   NP_076055
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397141,276,583 - 141,308,428 (+)NCBI
GRCm387141,690,340 - 141,754,691 (+)NCBI
MGSCv377148,876,261 - 148,890,250 (+)RGD
Celera7141,484,064 - 141,510,532 (+)NCBI
Sequence:
RefSeq Acc Id: NP_076055   ⟸   NM_023566
- Peptide Label: precursor
- UniProtKB: Q9CVG8 (UniProtKB/Swiss-Prot),   Q8K0Q1 (UniProtKB/Swiss-Prot),   Q80Z19 (UniProtKB/Swiss-Prot),   Q80Z17 (UniProtKB/Swiss-Prot),   Q0P637 (UniProtKB/Swiss-Prot),   A0A087WSG8 (UniProtKB/Swiss-Prot),   Q9Z2U5 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000026590   ⟸   ENSMUST00000026590
Ensembl Acc Id: ENSMUSP00000139657   ⟸   ENSMUST00000191587
Ensembl Acc Id: ENSMUSP00000141040   ⟸   ENSMUST00000185406
Ensembl Acc Id: ENSMUSP00000140855   ⟸   ENSMUST00000185823
Ensembl Acc Id: ENSMUSP00000136692   ⟸   ENSMUST00000179227
Ensembl Acc Id: ENSMUSP00000141128   ⟸   ENSMUST00000187945
Ensembl Acc Id: ENSMUSP00000140349   ⟸   ENSMUST00000187789
Ensembl Acc Id: ENSMUSP00000128250   ⟸   ENSMUST00000167366
Protein Domains
CTCK   TIL   VWF/SSPO/Zonadhesin-like cysteine-rich   VWFC   VWFD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80Z19-F1-model_v2 AlphaFold Q80Z19 1-2680 view protein structure

Promoters
RGD ID:8666159
Promoter ID:EPDNEW_M11111
Type:multiple initiation site
Name:Muc2_1
Description:Mus musculus mucin 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387141,690,340 - 141,690,400EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1339364 AgrOrtholog
Ensembl Genes ENSMUSG00000025515 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000185406 ENTREZGENE
  ENSMUST00000185406.8 UniProtKB/Swiss-Prot
Gene3D-CATH Laminin UniProtKB/Swiss-Prot
InterPro Cys_knot_C UniProtKB/Swiss-Prot
  Mucin_vWF_Thrombospondin_sf UniProtKB/Swiss-Prot
  Ser_inhib-like_sf UniProtKB/Swiss-Prot
  TIL_dom UniProtKB/Swiss-Prot
  Unchr_dom_Cys-rich UniProtKB/Swiss-Prot
  VWF_dom UniProtKB/Swiss-Prot
  VWF_type-D UniProtKB/Swiss-Prot
  WxxW_domain UniProtKB/Swiss-Prot
MGD MGI:1339364 ENTREZGENE
NCBI Gene 17831 ENTREZGENE
PANTHER EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED UniProtKB/Swiss-Prot
  MUCIN-2 UniProtKB/Swiss-Prot
Pfam Mucin2_WxxW UniProtKB/Swiss-Prot
  PF08742 UniProtKB/Swiss-Prot
  TIL UniProtKB/Swiss-Prot
  VWD UniProtKB/Swiss-Prot
  VWF UniProtKB/Swiss-Prot
PhenoGen Muc2 PhenoGen
PRINTS PRICHEXTENSN UniProtKB/Swiss-Prot
PROSITE CTCK_1 UniProtKB/Swiss-Prot
  CTCK_2 UniProtKB/Swiss-Prot
  VWFC_1 UniProtKB/Swiss-Prot
  VWFC_2 UniProtKB/Swiss-Prot
  VWFD UniProtKB/Swiss-Prot
SMART SM00041 UniProtKB/Swiss-Prot
  SM00832 UniProtKB/Swiss-Prot
  VWC UniProtKB/Swiss-Prot
  VWC_out UniProtKB/Swiss-Prot
  VWD UniProtKB/Swiss-Prot
Superfamily-SCOP FnI-like domain UniProtKB/Swiss-Prot
  SSF57567 UniProtKB/Swiss-Prot
UniProt A0A087WSG8 ENTREZGENE
  MUC2_MOUSE UniProtKB/Swiss-Prot
  Q0P622_MOUSE UniProtKB/TrEMBL
  Q0P623_MOUSE UniProtKB/TrEMBL
  Q0P637 ENTREZGENE
  Q17S18_MOUSE UniProtKB/TrEMBL
  Q80Z17 ENTREZGENE
  Q80Z19 ENTREZGENE
  Q8CIA2_MOUSE UniProtKB/TrEMBL
  Q8K0Q1 ENTREZGENE
  Q9CVG8 ENTREZGENE
  Q9JKY4_MOUSE UniProtKB/TrEMBL
  Q9R1L0_MOUSE UniProtKB/TrEMBL
  Q9WVG0_MOUSE UniProtKB/TrEMBL
  Q9Z2U5 ENTREZGENE
UniProt Secondary A0A087WSG8 UniProtKB/Swiss-Prot
  Q0P637 UniProtKB/Swiss-Prot
  Q80Z17 UniProtKB/Swiss-Prot
  Q8K0Q1 UniProtKB/Swiss-Prot
  Q9CVG8 UniProtKB/Swiss-Prot
  Q9Z2U5 UniProtKB/Swiss-Prot