Imported Disease Annotations - ClinVarObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Mog | Mouse | megacolon | | ISO | MOG (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Megacolon | ClinVar | PMID:21681106 | Mog | Mouse | Narcolepsy 7 | | ISO | MOG (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Narcolepsy 7 | ClinVar | PMID:21907016 and PMID:25741868 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Imported Disease Annotations - CTD
Imported Disease Annotations - OMIM
Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Gene Ontology Annotations Click to see Annotation Detail View
Biological Process
Cellular Component
Molecular Function
Phenotype Annotations Click to see Annotation Detail View
Mammalian Phenotype
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Biological Process
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Cellular Component
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Phenotype Annotations
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Mammalian Phenotype
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Purification and partial structural and functional characterization of mouse myelin/oligodendrocyte glycoprotein. | Amiguet P, etal., J Neurochem 1992 May;58(5):1676-82. |
| 2. | Characterization of two class I genes from the H2-M region: evidence for a new subfamily. | Arepalli SR, etal., Immunogenetics 1998;47(3):264-71. |
| 3. | Calcium influx and calpain activation mediate preclinical retinal neurodegeneration in autoimmune optic neuritis. | Hoffmann DB, etal., J Neuropathol Exp Neurol. 2013 Aug;72(8):745-57. doi: 10.1097/NEN.0b013e31829c7370. |
| 4. | MHC class I gene organization in > 1.5-Mb YAC contigs from the H2-M region. | Jones EP, etal., Genomics 1995 May 1;27(1):40-51. |
| 5. | Functional annotation of a full-length mouse cDNA collection. | Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90. |
| 6. | Relationship between NMO-antibody and anti-MOG antibody in optic neuritis. | Kezuka T, etal., J Neuroophthalmol. 2012 Jun;32(2):107-10. doi: 10.1097/WNO.0b013e31823c9b6c. |
| 7. | The magnitude and encephalogenic potential of autoimmune response to MOG is enhanced in MOG deficient mice. | Linares D, etal., J Autoimmun. 2003 Dec;21(4):339-51. |
| 8. | Electronic Transfer of Homolog Data | MGD and Homologene mouse data transfer |
| 9. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 10. | MGD IEA | MGD IEA |
| 11. | Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
| 12. | OMIM Disease Annotation Pipeline | OMIM Disease Annotation Pipeline |
| 13. | Genetic variation in myelin oligodendrocyte glycoprotein expression and susceptibility to experimental autoimmune encephalomyelitis. | Pagany M, etal., J Neuroimmunol. 2003 Jun;139(1-2):1-8. |
| 14. | Physical mapping of the human and mouse MOG gene at the distal end of the MHC class Ib region. | Pham-Dinh D, etal., Immunogenetics 1995;42(5):386-91. |
| 15. | Myelin/oligodendrocyte glycoprotein is a member of a subset of the immunoglobulin superfamily encoded within the major histocompatibility complex. | Pham-Dinh D, etal., Proc Natl Acad Sci U S A 1993 Sep 1;90(17):7990-4. |
| 16. | Mouse MP Annotation Import Pipeline | RGD automated import pipeline |
| 17. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 18. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 19. | Myelin oligodendrocyte glycoprotein induces experimental autoimmune encephalomyelitis in the "resistant" Brown Norway rat: disease susceptibility is determined by MHC and MHC-linked effects on the B cell response. | Stefferl A, etal., J Immunol. 1999 Jul 1;163(1):40-9. |
| 20. | BAC/YAC contigs from the H2-M region of mouse Chr 17 define gene order as Znf173-Tctex5-mog-D17Tu42-M3-M2. | Yoshino M, etal., Immunogenetics 1998 Apr;47(5):371-80. |
| 21. | Downregulation of microRNA-199a-5p alleviated lidocaine-induced sensory dysfunction and spinal cord myelin lesions in a rat model. | Zhang Z, etal., Toxicol Lett. 2021 Jan 1;336:1-10. doi: 10.1016/j.toxlet.2020.11.001. Epub 2020 Nov 6. |
| 22. | Identification of a pathogenic antibody response to native myelin oligodendrocyte glycoprotein in multiple sclerosis. | Zhou D, etal., Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19057-62. Epub 2006 Dec 1. |
Additional References at PubMed
Genomics
Comparative Map Data
| Mog (Mus musculus - house mouse) |
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| MOG (Homo sapiens - human) |
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| Mog (Rattus norvegicus - Norway rat) |
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| Mog (Chinchilla lanigera - long-tailed chinchilla) |
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| MOG (Pan paniscus - bonobo/pygmy chimpanzee) |
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| MOG (Canis lupus familiaris - dog) |
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| Mog (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| MOG (Sus scrofa - pig) |
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| MOG (Chlorocebus sabaeus - green monkey) |
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| Mog (Heterocephalus glaber - naked mole-rat) |
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miRNA Target Status
Predicted Target Of
| The detailed report is available here: |  | Full Report | | CSV | | TAB | | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
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QTLs in Region (GRCm39)
| The following QTLs overlap with this region. | | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Markers in Region
| Mog |
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| Mog |
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| Mog |
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| Mog |
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| MGI:3622176 |
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Expression
RNA-SEQ Expression
Sequence
Nucleotide Sequences
| Ensembl Acc Id: | ENSMUST00000102665 ⟹ ENSMUSP00000099726 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Ensembl Acc Id: | ENSMUST00000167275 ⟹ ENSMUSP00000129489 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_010814 ⟹ NP_034944 | ||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||||||
| Position: |
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| Sequence: |
Protein Sequences
| RefSeq Acc Id: | NP_034944 ⟸ NM_010814 |
| - Peptide Label: | precursor |
| - UniProtKB: | Q62003 (UniProtKB/Swiss-Prot), P70364 (UniProtKB/Swiss-Prot), Q61885 (UniProtKB/Swiss-Prot), Q3UY21 (UniProtKB/TrEMBL) |
| - Sequence: |
| Ensembl Acc Id: | ENSMUSP00000129489 ⟸ ENSMUST00000167275 |
| Ensembl Acc Id: | ENSMUSP00000099726 ⟸ ENSMUST00000102665 |
Protein Structures
| Name | Modeler | Protein Id | AA Range | Protein Structure |
| AF-Q61885-F1-model_v2 | AlphaFold | Q61885 | 1-246 | view protein structure |
Promoters
| RGD ID: | 13676038 | ||||||||
| Promoter ID: | EPDNEW_M22168 | ||||||||
| Type: | initiation region | ||||||||
| Name: | Mog_1 | ||||||||
| Description: | Mus musculus myelin oligodendrocyte glycoprotein , mRNA. | ||||||||
| SO ACC ID: | SO:0000170 | ||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
| Experiment Methods: | Single-end sequencing. | ||||||||
| Position: |
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| RGD ID: | 6828367 | ||||||||
| Promoter ID: | MM_KWN:23424 | ||||||||
| Type: | Non-CpG | ||||||||
| SO ACC ID: | SO:0000170 | ||||||||
| Source: | MPROMDB | ||||||||
| Tissues & Cell Lines: | Brain | ||||||||
| Transcripts: | NM_010814, UC008CLY.1 | ||||||||
| Position: |
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Additional Information
External Database Links
| Database | Acc Id | Source(s) |
| AGR Gene | MGI:97435 | AgrOrtholog |
| Ensembl Genes | ENSMUSG00000076439 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSMUST00000102665 | ENTREZGENE |
| ENSMUST00000102665.11 | UniProtKB/TrEMBL | |
| ENSMUST00000167275.3 | UniProtKB/TrEMBL | |
| Gene3D-CATH | 2.60.40.10 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| InterPro | Ig-like_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| Ig-like_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| Ig-like_fold | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| Ig_sub | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| Ig_V-set | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| IgSF_BTN/MOG | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| Myelin-oligodendrocyte_glycop | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| KEGG Report | mmu:17441 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| MGD | MGI:97435 | ENTREZGENE |
| NCBI Gene | 17441 | ENTREZGENE |
| PANTHER | BUTYROPHILIN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| MYELIN-OLIGODENDROCYTE GLYCOPROTEIN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| Pfam | V-set | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| PhenoGen | Mog | PhenoGen |
| PIRSF | MOG | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| PROSITE | IG_LIKE | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| SMART | IGv | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| SM00409 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| Superfamily-SCOP | SSF48726 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| UniProt | MOG_MOUSE | UniProtKB/Swiss-Prot |
| P70364 | ENTREZGENE | |
| Q29ZQ5_MOUSE | UniProtKB/TrEMBL | |
| Q3UY21 | ENTREZGENE, UniProtKB/TrEMBL | |
| Q61885 | ENTREZGENE | |
| Q62003 | ENTREZGENE | |
| Q66JM2_MOUSE | UniProtKB/TrEMBL | |
| Q80YU5_MOUSE | UniProtKB/TrEMBL | |
| UniProt Secondary | P70364 | UniProtKB/Swiss-Prot |
| Q62003 | UniProtKB/Swiss-Prot |